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Medicine (Baltimore) ; 98(48): e17750, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31770193


The aim of this study was to evaluate the cost-effectiveness of Anbainuo (ABN) plus methotrexate (MTX) (ABN + MTX) versus conventional disease-modifying anti-rheumatic drugs (cDMARDs) in rheumatoid arthritis (RA) patients.Forty-eight moderate to severe RA patients underwent ABN + MTX or cDMARDs treatment were consecutively enrolled and assigned to ABN + MTX group (n = 26) and control group (n = 22). Patients were followed up and their disease activity and quality of life (QoL) were evaluated at 3rd month, 6th month and 12th month after initiation of treatment. Treatment costs of 2 groups were calculated, then pharmacoeconomic analysis was performed.ABN + MTX increased drug cost and total cost while decreased indirect cost compared with cDMARDs after 12-month treatment. ABN + MTX group gained additional 0.22 quality-adjusted life years (QALY) and yielded an incremental cost-effectiveness ratio (ICER) of ¥104,293.6 per QALY after treatment. Sensitivity analysis reveals that rising ABN price by 20% produced an ICER of ¥130,403.6 per QALY, which was still lower than 3 times of the mean gross domestic product (GDP) per capita during the same period in China (¥165,960). Besides, ABN + MTX was more cost-effective in severe RA patients compared to moderate RA patients.ABN + MTX is cost-effective in treating moderate to severe RA patients compared with cDMARDs, although the total cost of ABN + MTX is relatively higher.

Antirreumáticos/economia , Artrite Reumatoide/tratamento farmacológico , Medicamentos Biossimilares/economia , Custos de Medicamentos/estatística & dados numéricos , Fragmentos Fc das Imunoglobulinas/economia , Metotrexato/economia , Receptores Tipo II do Fator de Necrose Tumoral/economia , Proteínas Recombinantes de Fusão/economia , Idoso , Antirreumáticos/administração & dosagem , Artrite Reumatoide/economia , Medicamentos Biossimilares/administração & dosagem , Análise Custo-Benefício , Quimioterapia Combinada/economia , Feminino , Humanos , Fragmentos Fc das Imunoglobulinas/administração & dosagem , Masculino , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Anos de Vida Ajustados por Qualidade de Vida , Receptores Tipo II do Fator de Necrose Tumoral/administração & dosagem , Proteínas Recombinantes de Fusão/administração & dosagem , Índice de Gravidade de Doença , Resultado do Tratamento
Guang Pu Xue Yu Guang Pu Fen Xi ; 29(3): 616-9, 2009 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-19455785


The traditional method of measuring the aeroengine exhausts is intrusive gas sampling analysis techniques. The disadvantages of the techniques include complex system, difficult operation, high costs and potential danger because of back-pressure effects. The non-intrusive methods have the potential to overcome these problems. So the remote FTIR passive sensing is applied to monitor aeroengine exhausts and determine the concentration of the exhausts gases of aeroengines. The principle of FTIR remote passive sensing is discussed. The model algorithm for the calibration of FTIR system, the radiance power distribution and gas concentration are introduced. TENSOR27 FTIR-system was used to measure the spectra of infrared radiation emitted by the hot gases of exhausts in a test rig. The emission spectra of exhausts were obtained under different thrusts. By analyzing the spectra, the concentrations of CO2, CO and NO concentration were calculated under 4 thrusts. Researches on the determination of concentration of the exhausts gases of aeroengines by using the remote FTIR sensing are still in early stage in the domestic aeronautics field. The results of the spectra and concentration in the aeroengine test are published for the first time. It is shown that the remote FTIR passive sensing techniques have a great future in monitoring the hot gas of the aeroengines exhausts.