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1.
J Clin Med ; 10(18)2021 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-34575366

RESUMO

BACKGROUND: We aimed to study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT). METHODS: All subjects underwent a wide-field 16-mm one-line scan using SS-OCT. Bilateral CT was measured at, and compared among, the following 12 points: three points at 900-µm intervals from the nasal optic disc margin (nasal peripapillary area), one point at the subfovea, six points at 900-µm intervals from the fovea to the nasal and temporal areas (macular area), and two peripheral points 5400 and 8100 µm from the fovea (peripheral area). RESULTS: There were no statistically significant differences in CT between the right and left eyes in any area (all p > 0.05); they all showed significant positive correlations (all p < 0.01). However, the correlation coefficients (ρ) were smaller for the nasal peripapillary and peripheral areas compared to the macular area. CONCLUSIONS: The CTs in each region were bilaterally symmetrical in subjects with uncomplicated pachychoroid. However, interocular difference in CT increased from the center to the periphery, indicating that the anatomical variation of the nasal peripapillary and peripheral choroid was greater than that of the macula.

2.
Acta Ophthalmol ; 99(7): e1056-e1062, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33555661

RESUMO

PURPOSE: To determine longitudinal changes of the ganglion cell-inner plexiform layer (GC-IPL) thickness in patients with non-exudative age-related macular degeneration (AMD) without other ophthalmic disease. METHODS: Thirty-three eyes of 33 patients with early and intermediate non-exudative AMD (non-exudative AMD group) and 33 normal control eyes were followed for 2 years, and GC-IPL thickness was measured by spectral domain optical coherence tomography at 1-year intervals. The mean rate of GC-IPL reduction was estimated using a linear mixed model and compared between two groups. RESULTS: The mean age of patients in the non-exudative AMD group and control groups were 68.82 ± 6.81 years and 67.73 ± 5.87 years, respectively (p = 0.488). The mean GC-IPL thickness at the first visit was 76.61 ± 16.33 µm in the non-exudative AMD and 81.76 ± 3.69 µm in control group (p = 0.387), and these values significantly decreased over time, with an average reduction rate of average GC-IPL -0.86 µm/year in the non-exudative AMD group and -0.32 µm/year in the control group. The difference between two groups was statistically significant (p < 0.001), and there was also a significant interaction between group and duration in linear mixed models in mean GC-IPL thickness (p = 0.001). CONCLUSIONS: The reduction rate of the GC-IPL thickness was greater in non-exudative AMD eyes, even at relatively early stages of the disease. Physicians should maintain awareness of the presence of non-exudative AMD in various cases of ophthalmic diseases where GC-IPL thickness evaluation is necessary.


Assuntos
Degeneração Macular/diagnóstico , Células Ganglionares da Retina/patologia , Tomografia de Coerência Óptica/métodos , Idoso , Progressão da Doença , Feminino , Seguimentos , Humanos , Masculino , Fibras Nervosas/patologia , Estudos Prospectivos
3.
Ophthalmic Plast Reconstr Surg ; 37(3S): S44-S47, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32773515

RESUMO

PURPOSE: To evaluate the efficacy of triamcinolone-soaked nasal packing in endoscopic dacryocystorhinostomy (EDCR). METHODS: Patients who underwent EDCR between September 2012 and August 2017 were included. They were assigned to triamcinolone (201 eyes) or control (206 eyes) group based on the order of surgery. Granulation occurrence and outcome were assessed at 3 and 6 months postoperatively, respectively. RESULTS: The success rates were 94.3% (overall anatomical success), 90.4% (complete anatomical success), 92.1% (overall functional success), and 76.7% (complete functional success). The overall functional success rate was significantly higher in the triamcinolone group (95.0% vs. 89.3%, p = 0.033). The overall anatomical success rate (96.0% vs. 92.7%, p = 0.149) and complete functional success rate (79.6% vs. 73.8%, p = 0.166) were also higher in the triamcinolone group, but this difference was not statistically significant. Granulation occurred in 62 eyes (15.2%); the incidence was significantly lower in the triamcinolone group (10.0% vs. 20.4%, p = 0.003). CONCLUSION: The authors suggest that use of triamcinolone-soaked nasal packing in EDCR is effective in significantly reducing the incidence of postoperative granulation and epiphora.


Assuntos
Dacriocistorinostomia , Doenças do Aparelho Lacrimal , Endoscopia , Epistaxe , Humanos , Estudos Retrospectivos , Resultado do Tratamento , Triancinolona
4.
Acta Ophthalmol ; 99(1): e117-e123, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32573109

RESUMO

PURPOSE: We investigated the wide-field choroidal thickness (CT) using swept-source optical coherence tomography (SS-OCT) and compared the characteristics of the choroidal layer between pachychoroid and normochoroid groups. METHODS: A total of 120 eyes from 120 normal subjects were included. All subjects were divided into two groups according to the subfoveal CT (≥300 µm, pachychoroid group; <300µm, normochoroid group). All subjects underwent an HD spotlight 16 mm scan using SS-OCT. The CT was measured at the following 12 points: subfoveal, 3 points in the nasal peripapillary area, 6 points in the macular area and 2 peripheral points at 5400 and 8100 µm from the fovea. The CT measurements were compared between the two groups, and statistical analyses were performed to determine clinical factors associated with each point of the CT. RESULTS: The CT in the pachychoroid group was thicker than that in the normochoroid group at all points (p < 0.01). The CTs of the two groups in the macular area were highly associated with the subfoveal CT. However, the CTs of the nasal peripapillary and peripheral areas showed lower associations with the subfoveal CT and lower diagnostic abilities for the pachychoroid group. The existence of pachyvessels was found to be a significant factor causing the regional variations. CONCLUSIONS: The CTs in the peripapillary and peripheral areas showed different patterns than the subfoveal CT. Regional variations by pachyvessels were more frequent in the peripapillary and peripheral areas than in the macular area, and the subfoveal CT did not represent the whole choroidal area.


Assuntos
Corioide/diagnóstico por imagem , Tomografia de Coerência Óptica/métodos , Adulto , Feminino , Seguimentos , Humanos , Masculino , Reprodutibilidade dos Testes , Estudos Retrospectivos
5.
BMC Ophthalmol ; 20(1): 286, 2020 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-32660545

RESUMO

BACKGROUND: Although many studies have reported clinical features, surgical outcomes of rhegmatogenous retinal detachment (RRD), studies focusing on total RRD are rare. In this study, we investigate the clinical characteristics, risk factors, and prognosis of total RRD. METHODS: A retrospective chart review was performed on cases of 44 total RRD and an age- and sex-matched 88 partial RRD. Two groups were compared for clinical characteristics, risk factors, and prognosis. RESULTS: The prevalence of total RRD in all cases of retinal detachment was 4.4%. Pseudophakic eye, ocular trauma, and proliferative vitreoretinopathy (PVR) were significantly associated with a risk of total RRD (P = .002, P = .003, and P < .001, respectively). In the total RRD group, retinal breaks were located in both superior and inferior parts of the retina, and macular holes and giant retinal tears were frequently found. The best-corrected visual acuity (log MAR) before surgery and final best-corrected visual acuity after surgery were 2.23 ± 0.45 and 1.88 ± 0.96, which was significantly poorer than in the partial RRD group (P < .001). The success rate after primary surgery was 75.0% in the total RRD group, which was significantly lower than partial RRD group (P < .001). Old age, pseudophakic eye, and macular hole as the type of retinal break were highly associated with low success rate. (P = .010, P = .0500, and P = .002). CONCLUSIONS: Patients with total RRD had higher recurrence rate and poorer visual outcome after surgery than patients with focal RRD. Old age, pseudophakic eye, and presence of macular hole were important risk factors for recurrence after total RRD repair. Additional surgical procedures should be considered to combine with vitrectomy to achieve better surgical outcomes in these patients.


Assuntos
Descolamento Retiniano , Perfurações Retinianas , Estudos de Casos e Controles , Humanos , Prognóstico , Descolamento Retiniano/epidemiologia , Descolamento Retiniano/cirurgia , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/epidemiologia , Perfurações Retinianas/cirurgia , Estudos Retrospectivos , Acuidade Visual , Vitrectomia
6.
J Ophthalmol ; 2020: 5686894, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32377420

RESUMO

PURPOSE: To evaluate the difference in the repeatability of automated superficial retinal vessel density and foveal avascular zone (FAZ) metrics according to the measurement area of optical coherence tomography angiography (OCTA). METHODS: A total of 127 normal eyes from 127 healthy subjects were included. Macular angiography images were acquired from all subjects using the Zeiss Cirrus 5000 with AngioPlex™ OCTA software. Scans of 3 × 3 mm and 6 × 6 mm were each performed twice in a randomly arranged sequence. Vessel density (VD), perfusion density (PD), and FAZ metrics of the superficial capillary plexus were calculated automatically for all scans, and the repeatabilities for both scan patterns were assessed based on intraclass correlation (ICC), coefficient of variation (CV), and coefficient of repeatability (CR) parameters. The average measured values in the two scan patterns were also compared. RESULTS: VD was significantly greater in the 3 × 3 mm scan than in the 6 × 6 mm scan according to all parameters, whereas PD was significantly less in the 3 × 3 mm scan than in the 6 × 6 mm scan. The ICCs for VDs in the central fovea were 0.826 and 0.741 for the 3 × 3 and 6 × 6 mm scans, respectively, and the CVs were 8.00% and 12.75%. For PDs, the ICCs were 0.839 and 0.762 and the CVs were 9.32% and 14.90%. The FAZ metrics in the 3 × 3 mm scan showed good repeatability with an ICC >0.75 and a CV <10.0%. However, all ICCs for the 6 × 6 mm scans were <0.75, and the CVs were all >10%. CONCLUSIONS: The 6 × 6 mm macular angiography scans resulted in lower repeatabilities than the 3 × 3 mm scans according to all OCTA parameters, particularly in the central fovea and FAZ metrics. The 3 × 3 mm scan was more suitable than the 6 × 6 mm scan for analyzing macular microvascular density and FAZ metrics.

7.
Korean J Ophthalmol ; 34(2): 133-142, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32233147

RESUMO

PURPOSE: We report the clinical outcomes of retinal capillary hemangioma (RCH) after the application of various treatments. METHODS: We performed a retrospective chart analysis of eight eyes treated for RCH between August 2009 and January 2018. During the follow-up period, the status and progression of the RCHs were checked by fundus photography, fluorescein angiography, and optical coherence tomography, and additional treatments were applied when necessary. RESULTS: Three of the five patients had bilateral RCH, and two had unilateral RCH. Six eyes received laser photocoagulation; two eyes received cryotherapy, and one eye received intravitreal Avastin injection. Three eyes each had intravitreal triamcinolone injection, subtenon triamcinolone injection, and intravitreal dexamethasone injection to control inflammation. Also, two patients took oral prednisolone, and one patient used prednisolone eye drops to control inflammation. Two eyes underwent vitrectomy and scleral buckling due to deterioration of the epiretinal membrane and vitreal traction, respectively. As a result of those treatments, the tumors were stable in five of the eight eyes. However, one eye is now in a pre-phthisis state, and one patient who refused treatment showed progression of the tumor, epiretinal membrane, and traction. CONCLUSIONS: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should be actively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determine recurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patients to ensure that they have no abnormalities other than in the eye.


Assuntos
Bevacizumab/administração & dosagem , Hemangioma Capilar/tratamento farmacológico , Retina/patologia , Neoplasias da Retina/tratamento farmacológico , Tomografia de Coerência Óptica/métodos , Acuidade Visual , Adolescente , Adulto , Inibidores da Angiogênese/administração & dosagem , Feminino , Angiofluoresceinografia/métodos , Seguimentos , Fundo de Olho , Hemangioma Capilar/diagnóstico , Humanos , Injeções Intravítreas , Masculino , Receptores de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores , Neoplasias da Retina/diagnóstico , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
8.
Acta Ophthalmol ; 98(1): e50-e55, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31545561

RESUMO

PURPOSE: To determine the changes in peripapillary retinal nerve fiber layer (pRNFL), macular and ganglion cell-inner plexiform layer (GC-IPL) thicknesses in patients with acute anterior uveitis (AAU). METHODS: Patients diagnosed with unilateral non-infectious AAU and normal control were enrolled retrospectively. Optical coherence tomography scans were performed during the initial active phase and inactive phase of AAU. Patients were followed for at least 3 months after resolution of inflammatory activity. RESULTS: Thirty-seven AAU patients and 40 controls were included. The average RNFL and central macular thickness (CMT) showed significant differences between patients and control groups during active phase (p < 0.001 and p = 0.022, respectively). The average pRNFL thicknesses of affected eyes and fellow eyes during the active phase were 109.4 ± 12.5 µm and 96.5 ± 8.0 µm, respectively (p < 0.001). During the inactive phase, the average thicknesses were 99.3 ± 8.9 µm and 97.0 ± 7.5, respectively; they were not significantly different (p = 0.236). The CMTs of affected and fellow eyes during the active phase were 261.6 ± 24.7 µm and 251.5 ± 17.3 µm, respectively; the difference was significant (p = 0.047). The average GC-IPL thicknesses of affected and fellow eyes were not significantly different (p = 0.061). CONCLUSIONS: The pRNFL and central macula thickened during the active phase of AAU and decreased to a similar degree with fellow eyes during the inactive phase. Additionally, pRNFL thickness showed a sensitive response to the degree of inflammation in AAU. This suggests that pRNFL thickness may be useful in assessing disease activity.


Assuntos
Macula Lutea/patologia , Disco Óptico/patologia , Células Ganglionares da Retina/patologia , Tomografia de Coerência Óptica/métodos , Uveíte Anterior/diagnóstico , Doença Aguda , Adulto , Feminino , Humanos , Masculino , Estudos Retrospectivos
9.
Korean J Ophthalmol ; 33(1): 63-69, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30746913

RESUMO

PURPOSE: To evaluate the changes of axial length (AXL) in eyes with unilateral idiopathic central serous chorioretinopathy (CSC) after resolution of serous retinal detachment. METHODS: A total of 31 patients diagnosed with idiopathic unilateral CSC were included in this study. The changes of AXL according to serous retinal detachment were examined. The keratometric value and AXL were measured using partial coherence interferometry. Serous retinal detachment and central macular thickness (CMT) were measured by spectral domain optical coherence tomography. RESULTS: The mean age of the 31 CSC patients, including 19 males, was 42.7 years. The AXL was significantly increased from 23.41 to 23.58 mm after resolution of serous retinal detachment (p < 0.001). The CMT was significantly decreased from 413.4 to 226.8 µm after resolution of serous retinal detachment (p < 0.001). The differences in AXL correlated with CMT differences and subretinal fluid height (r = -0.616, p < 0.001 and r = -0.637, p < 0.001, respectively), and the best-corrected visual acuity was significantly different after resolution of serous retinal detachment (p < 0.001). CONCLUSIONS: In unilateral idiopathic CSC with serous retinal detachment, a shortened AXL in the acute phase was restored after resolution of serous retinal detachment.


Assuntos
Comprimento Axial do Olho/diagnóstico por imagem , Coriorretinopatia Serosa Central/complicações , Angiofluoresceinografia/métodos , Descolamento Retiniano/etiologia , Tomografia de Coerência Óptica/métodos , Acuidade Visual , Adulto , Coriorretinopatia Serosa Central/diagnóstico , Progressão da Doença , Feminino , Seguimentos , Fundo de Olho , Humanos , Masculino , Estudos Prospectivos , Descolamento Retiniano/diagnóstico
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