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1.
Br J Nutr ; : 1-30, 2020 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-32921321

RESUMO

This cross-sectional study aimed to examine the associations between dietary fibers (DF) intake and depressive symptoms in a general adult population in Tianjin, China. A total of 24,306 participants (mean age, 41 years; range 18-91 years) were enrolled. DF intake was assessed using a validated self-administered food frequency questionnaire. Depressive symptoms were assessed using the Self-Rating Depression Scale. Associations between DF intake and depressive symptoms were estimated using logistic regression analysis. Socio-demographic, behavioral, health status, and dietary factors were adjusted. In men, compared to participants in the lowest quartiles for total, soluble, vegetable, and soy DF, odds ratios (ORs; 95% confidence intervals [CIs]) for depressive symptoms in the highest were 0.83 (0.69, 0.99), 0.74 (0.63, 0.87), 0.79 (0.65, 0.96), and 0.69 (0.60, 0.81), respectively. In women, compared to participants in the lowest quartiles for vegetable and soy DF, the ORs (95% CIs) for depressive symptoms in the highest were 0.77 (0.64, 0.93) and 0.82 (0.70, 0.95), respectively. No association was found between total or soluble DF intake and depressive symptoms in women. No association was found between insoluble, cereal, fruit, or tuber DF intake and depressive symptoms in men and women. Linear associations between DF intake and depressive symptoms were only detected for soy foods DF (men, ß = -0.148, P < 0.0001; women, ß = -0.069, P = 0.04). Results suggest intake of soluble, vegetable, and soy DF were inversely associated with depressive symptoms. These results should be confirmed through prospective and interventional studies.

2.
Liver Int ; 2020 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-32885579

RESUMO

BACKGROUND & AIMS: Seaweeds are rich sources of anti-oxidants and anti-inflammatory properties, which are beneficial to non-alcoholic fatty liver disease (NAFLD). However, whether seaweed consumption is associated with NAFLD is unknown. We investigated the association of seaweed consumption with newly diagnosed NAFLD in a large-scale adult population. METHODS: This cross-sectional study involved 24,572 participants aged over 18 years. NAFLD was diagnosed by results of liver ultrasonography and alcohol intake. Dietary information was assessed using a validated and standardized 100-item food frequency questionnaire. Multivariate logistic analysis was used to evaluate the association between seaweed consumption and NAFLD. RESULTS: The prevalence of newly diagnosed NAFLD was 20.1%. After adjustment for sociodemographic characteristics, lifestyle factors, and other dietary intakes, the multivariable adjusted odds ratios (95% confidence intervals) of newly diagnosed NAFLD across seaweed consumption were 1.00 (reference) for almost never, 1.03 (0.93, 1.15) for <1 time/week, 1.01 (0.90, 1.13) for 1 time/week, and 0.84 (0.73, 0.96) for >1 times/week (P for trend <0.001). Stratified analyses suggested a potential effect modification by obesity status; the odds ratios (95% confidence intervals) across extreme quartiles was 0.77 (0.66, 0.91) in non-obese participants and 1.02 (0.79, 1.33) in obese participants (P for interaction < 0.001). CONCLUSION: Seaweed consumption is negatively associated with NAFLD, especially in non- obese participants.

3.
Br J Nutr ; : 1-25, 2020 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-32799936

RESUMO

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Recent evidence has suggested the protective effects of honey consumption against metabolic syndrome, but the association between honey intake and NAFLD is still unclear. We investigated how the consumption frequency of honey was associated with NAFLD in the general population. This was a cross-sectional study of 21,979 adults aged 20-90 years. NAFLD was diagnosed based on the ultrasound-diagnosed fatty liver without significant alcohol intake and other liver diseases. Diet information, including consumption frequency of honey, was assessed by a validated 100 item food frequency questionnaire. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by the binary logistic regression model, adjusting for confounding factors identified by the directed acyclic graph. Overall, 6,513 adults (29.6%) had NAFLD. Compared with participants consuming ≤1 time/week of honey, the multivariable ORs (95% CIs) of NAFLD were 0.86 (0.77, 0.97) for 2-6 times/week and 1.10 (0.95, 1.27) for ≥1 times/day (P for trend = 0.90). The results were generally similar in subgroups of body mass index at a cut-point of 24.0 kg/m2 (P for interaction = 0.10). In this large-scale study, consuming honey 2-6 times/week was inversely associated with NAFLD, whereas consuming honey ≥1 times/day had no association with NAFLD. These results need replication in other large-scale prospective studies.

4.
Nutr Res ; 80: 78-88, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32736293

RESUMO

Fast eating speed is a risk factor for obesity, which is also closely related to nonalcoholic fatty liver disease (NAFLD), suggesting that fast eating speed may contribute to the development of NAFLD. But the extent to which obesity may mediate the association between eating speed and NAFLD is uncertain. We hypothesized that obesity plays a mediating role in the association between eating speed and prevalence of NAFLD in the general population. A cross-sectional study (n = 23,611) was conducted in a general population sample from Tianjin, China. We measured anthropometrics and biochemical variables. The self-reported eating speed per meal was recorded and classified into 4 categories: slow, medium, relatively fast, and very fast. NAFLD was diagnosed by liver ultrasonography. Multiple logistic regression analysis was used to assess the associations between the eating speed and the prevalence of NAFLD, as well as the mediation effects of obesity on the association between eating speed and NAFLD. The prevalence of newly diagnosed NAFLD was 19.0%. After adjusting for potentially confounding factors, the odds ratios (95% confidence interval) of NAFLD across categories of eating speed were 1.00 (reference), 1.39 (1.18-1.64), 1.71 (1.45-2.01), and 2.04 (1.70-2.46). All these significant odds ratios were attenuated to be nonsignificant by adjustment for body mass index and/or waist circumference. This is the first study to demonstrate that eating speed is not independently associated with increased risk of NAFLD.

5.
Nutr Metab Cardiovasc Dis ; 30(10): 1645-1652, 2020 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-32669242

RESUMO

BACKGROUND AND AIMS: Research evidence supports a positive link between sugar-containing soft beverages and hyperuricemia. However, data thus far are mostly from Caucasian populations. And in sugar-containing soft beverages overall, sugar-containing carbonated beverages are purchased most often. Therefore, we investigated whether the high consumption of sugar-containing carbonated beverages was associated with the prevalence of hyperuricemia among adults in China. METHODS AND RESULTS: A cross-sectional study was conducted with 25,507 adults (13,013 men and 12,494 women) in Tianjin, China. Sugar-containing carbonated beverages intake was assessed by a validated semi-quantitative food frequency questionnaire. Hyperuricemia was defined as serum uric acid levels ≥7.0 mg/dL in men and ≥ 6 mg/dL in women. The association between carbonated beverages consumption and hyperuricemia was assessed by multiple logistic regression analysis. The prevalence of hyperuricemia in men and women was 23.4% and 8.2%, respectively. After adjustments for potential confounding factors, the odds ratios (95% confidence interval) for hyperuricemia across sugar-containing carbonated beverages consumption were 1.00 (reference) for almost never, 1.18 (1.05, 1.32) for <1-3 cups/week, 1.49 (1.25, 1.77) for ≥4 cups/week in men (P for trend < 0.005) and 1.11 (0.91, 1.34) for <1-3 cups/week (P for trend = 0.27), 1.70 (1.23, 2.31) for ≥4 cups/week in women (P for trend < 0.001), respectively. CONCLUSIONS: This cross-sectional survey demonstrated that increased consumption of sugar-containing carbonated beverages is associated with hyperuricemia among adults in China. Restricted sugar-containing carbonated beverages intake might be beneficial to the prevention of hyperuricemia in the general population.

6.
PLoS One ; 15(7): e0236010, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32649678

RESUMO

Tooth loss is a prevailing condition in China due to the high prevalence of oral diseases. Since previous studies explored the association between tooth loss and handgrip strength showed incongruous results, the aim of this study was to investigate the association between tooth loss and handgrip strength in Tianjin, China. Cross-sectional data in the present study used baseline data of Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study during 2013-2016. Eligible adults (n = 26275) were classified into four groups depending on the number of missing teeth (excluding third molars): 0, 1-2, 3-5 and ≥6. Handgrip strength was measured using a handheld type dynamometer. Analysis of covariance was used to examine the relationships between tooth loss and handgrip strength and handgrip strength per body weight according to gender. After adjustment for potential confounders, the relationships existed between increasing categories of tooth loss and handgrip strength, as well as handgrip strength per weight. The data of stratified analysis showed that there was a trending association between decreased handgrip strength and fewer retained teeth both in males and females less than 60 years of age (P for trend <0.01); whereas no significant association 60 years of age or older. Moreover, loss of more than 3 teeth was significantly associated with reduced muscle strength (P <0.01). Tooth loss is independently associated with handgrip strength in Chinese adults less than 60 years of age.

7.
Lipids Health Dis ; 19(1): 151, 2020 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-32586390

RESUMO

BACKGROUND: Coronary artery stenosis induces heart diseases including acute coronary syndrome (ACS). Some studies reported the ceramide species are associated with the ACS and major adverse cardia and cerebrovascular events (MACE). However, few studies investigated the association between plasma ceramide levels and the severity of stenosis, together with the onset of diseases. This aim of the present study was to investigate the association betweencertain ceramide species, coronary artery stenosis and acute coronary syndrome. METHODS: Five hundred fifty-three patients with definite or suspected CAD were recruited and received angiography. Subjects were assigned into 4 groups according to the severity of coronary artery stenosis. The measurements of 4 plasma ceramide species, namely, Cer (d18:1/16:0), Cer (d18:1/18:0), Cer (d18:1/24:1), Cer (d18:1/24:0) were carried out by Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the ratio of Cer (d18:1/16:0), Cer (d18:1/18:0) and Cer (d18:1/24:1) to Cer (18:1/24:0), respectively, were calculated as index to evaluate the association between plasma ceramides levels and coronary artery stenosis. Multiple logistic regression analysis was used to establish the prognostic model for the prediction of ACS risk. RESULTS: After the adjustment by multiple clinical risk factors including age, gender, pre-existing myocardial/cerebral infarction, hemoglobin A1c% (HbA1c%), smoking and the diagnosis during index hospitalization, multiple logistic regression analysis showed that the high ratio of Cer (d18:1/24:1) to Cer (d18:1/24:0), female gender, HbA1c%, unstable angina (UAP) and acute myocardial infarction (AMI) diagnosis (compared with atherosclerosis) during index hospitalization were associated with more severe coronary artery stenosis. Furthermore, the prognostic model was established after adjustment of risk factors and the area under curve (AUC) of receiver operating characteristics (ROC) for the prognostic model was 0.732 and 95% CI was 0.642-0.822. CONCLUSION: The severity of coronary artery stenosis is associated with high ratio of Cer (d18:1/24:1) to Cer (d18:1/24:0), female gender, HbA1c% and AMI. Although the reported prognostic model showed a good discrimination, further investigation on long term MACE is needed to evaluate the role of ceramide for the prediction of MACE risk.

8.
BMC Complement Med Ther ; 20(1): 109, 2020 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-32276586

RESUMO

BACKGROUND: Ligularia fischeri (Ledeb) Turcz (LFT) is a well-known expectorant and active anti-inflammatory agent in Chinese traditional medicine. LFT's expectorant effect is closely related to its anti-inflammatory effects. This study aimed to evaluate the differential composition and anti-inflammatory mechanisms of the volatile components in LFT from different production areas. METHOD: Headspace solid-phase microextraction-gas chromatography-mass spectrometry analysis of volatile components, as well as chemometric methods, including similarity analysis, hierarchical clustering analysis, and principal component analysis, were performed to identify LFT produced in different areas. The molecular mechanism underlying the anti-inflammatory effects of these components was determined by network pharmacology analysis. RESULTS: We observed significant differences in the chemical constituents and percentage contents in samples with different origins. Eighteen volatile components were identified in four different producing areas, among which the highest content of olefinic components was the main component of the aroma of LFT. The mechanisms of these pharmacological effects involved multiple targets and pathways. Twenty-seven potential target proteins and 65 signaling pathways were screened, and a "component-target-disease" interaction network map was constructed. The volatile components of the LFT function mainly by inhibiting the production of inflammatory factors. CONCLUSION: This study provides a theoretical framework for further development and application of LFT used in traditional Chinese medicine.

9.
Endocrine ; 2020 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-32328967

RESUMO

PURPOSE: Thyroid hormones (THs) have multiple effects on lipid synthesis, mobilization, and degradation, suggesting that THs may affect the development of dyslipidemia. However, prospective studies on the association between serum THs levels and incident dyslipidemia in euthyroid subjects are limited. Therefore, we conducted a cohort study (~5-year follow-up period, median: 3.0 years) to explore whether THs can affect incident dyslipidemia in a general euthyroid population aged 18 years old and over. METHODS: Dyslipidemia is characterized by elevated total cholesterol (TC), triglyceride (TG), or low-density lipoprotein cholesterol (LDL-C), or reduced high-density lipoprotein cholesterol (HDL-C). Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were determined by chemiluminescence immunoassay. Multivariable Cox proportional hazards regression models were used to assess the association between baseline FT3, FT4, TSH, and the risk of various dyslipidemias. RESULTS: During follow-up period, the incidence of elevated TC, TG, LDL-C, and reduced HDL-C was 29.3%, 20.7%, 24.8%, and 19.5%, respectively. After adjustment for multiple confounders, we found that per unit increase in FT3 concentrations were associated with decreased incidence of elevated TC and LDL-C, and the hazard ratios (95% confidence interval) were 0.87 (0.79-0.97) (P < 0.01) and 0.897 (0.808-0.995) (P = 0.04), respectively. We also found a weak positive association between TSH and incidence of reduced HDL-C (P = 0.02). However, we found no association between FT4 and incident dyslipidemia. CONCLUSIONS: Our results demonstrated that low FT3 was associated with high dyslipidemia risk, especially for elevated TC and LDL-C, and that TSH had a weak positive effect on incidence of reduced HDL-C.

10.
J Pharm Biomed Anal ; 186: 113287, 2020 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-32325402

RESUMO

Ai pian (AP) is a well-known Miao national herb with resuscitative effects. However, pharmacological and clinical applications of AP are limited because its precise molecular mechanism remains unclear. This study was conducted to evaluate the anti-inflammatory activities of the volatile compounds of AP in in vivo animal models and determine the molecular mechanism underlying the anti-inflammatory effects based on network pharmacology and molecular docking. We performed gas chromatography-mass spectrometric analysis of volatile compounds with chemometric methods, including hierarchical clustering analysis and principal component analysis, to identify AP from different origins. Mouse models of xylene-induced ear edema were used to examine the in vivo anti-inflammatory activities of AP with cotton ball-granulation test. The mechanism of AP was determined by network pharmacology analysis and molecular docking. Significant differences in chemical constituents and percentage contents were observed among different habitats. We found that AP exerted potent anti-inflammatory effect, and that multiple targets and pathways were involved in this effect. These results provided a foundation for further comprehensive development and application of AP from Miao national herb.

11.
BMC Public Health ; 20(1): 388, 2020 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-32209063

RESUMO

BACKGROUND: Early-life hormonal and nutritional factors can greatly influence the risk of non-alcoholic fatty liver disease (NAFLD). Adult height is a simple marker for these factors. This study aimed to investigate the association between adult height and NAFLD. METHODS: We performed a prospective cohort study of 35,994 participants aged 25 years or over with measured height at baseline. NAFLD was diagnosed by abdominal ultrasound and self-reported history of alcohol intake. Multivariable Cox proportional hazards regression models were conducted to assess the gender-specific association between height and the risk of NAFLD. RESULTS: During a follow-up period of 5.5 years, 6245 of 35,994 subjects developed NAFLD. The adjusted hazard ratios (95% confidence interval) of NAFLD for increasing quintiles of height were 1.00 (reference), 0.82 (0.73, 0.92), 0.84 (0.73, 0.97), 0.72 (0.61, 0.85) and 0.63 (0.50, 0.79) (P for trend < 0.0001) in males, and 1.00 (reference), 1.00 (reference), 0.80 (0.69, 0.91), 0.72 (0.61, 0.85), 0.60 (0.49, 0.74) and 0.45 (0.35, 0.59) (P for trend < 0.0001) in females, respectively. CONCLUSIONS: A higher adult height was associated with lower risk of NAFLD among males and females in Tianjin, China.


Assuntos
Estatura , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Adulto , Índice de Massa Corporal , China/epidemiologia , Feminino , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Medição de Risco , Circunferência da Cintura , Razão Cintura-Estatura
12.
Int J Food Sci Nutr ; : 1-7, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32126848

RESUMO

A cross-sectional study was conducted to explore the association between soft drink consumption and handgrip strength (HGS) in subjects aged 40 years and older (n = 14,925). After multivariable-adjustment (including demographics, lifestyles, family history of diseases, dietary intake, and other beverages consumption), the least square means (95% confidence interval) of HGS across soft drink consumption categories were 43.1(42.7, 43.5) kg for almost never drink, 42.9(42.4, 43.4) kg for <1 cup/week, 42.8(42.1, 43.5) kg for 1-6 cups/week and 41.2(40.1, 42.6) kg for ≥1 cup/day (p for trend < 0.001) in men, and 26.6(25.9, 27.8) kg for almost never drink, 26.5(25.8, 27.1) kg for <1 cup/week, 26.3(25.7, 27.2) kg for 1-6 cups/week and 25.2(24.9, 27.0) kg for ≥1 cup/day (p for trend < 0.001) in women, respectively. Our findings suggest that higher consumption of soft drinks was significantly associated with lower HGS in middle-aged and older adults. Additional prospective or interventional studies are needed to confirm this issue.

13.
Br J Nutr ; : 1-8, 2020 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-32122417

RESUMO

Evidence has suggested that honey intake has a beneficial impact on glycaemic control in patients with type 2 diabetes. Whether these findings apply to adults with prediabetes is yet unclear. The aim of the present study was to examine whether honey intake is associated with a lower prevalence of prediabetes. A cross-sectional study was performed in 18 281 participants (mean age 39·6 (sd 11·1) years; men, 51·5 %). Dietary intake was assessed through a validated 100-item FFQ. Prediabetes was defined according to the American Diabetes Association criteria: impaired fasting glucose, impaired glucose tolerance or raised glycosylated Hb. Multivariable logistic regression models were used to estimate the association between honey consumption and prediabetes. As compared with those who almost never consumed honey, the multivariable OR of prediabetes were 0·94 (95 % CI 0·86, 1·02) for ≤3 times/week, 0·77 (95 % CI 0·63, 0·94) for 4-6 times/week and 0·85 (95 % CI 0·73, 0·99) for ≥1 time/d (Pfor trend < 0·01). These associations did not differ substantially in sensitivity analysis. Higher honey consumption was associated with a decreased prevalence of prediabetes. More large prospective cohort studies are needed to investigate this association.

14.
Chemosphere ; 252: 126510, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32203783

RESUMO

The present study aimed to identify the effects of arsenic on behaviors in Caenorhabditis elegans (C. elegans) and the transgenerational effects. The synchronized C. elegans (P generation) were exposed to 0, 0.2, 1.0, and 5.0 mM NaAsO2 and the subsequent generations (F1 and F2) were maintained on fresh nematode growth medium (NGM). The behaviors and growth were recorded at 0, 12, 24, 36, 48, 60, and 72 h post synchronization. The results demonstrated that arsenic affected various indicators regarding the behavior (head thrash, body bend, movement speed, wavelength, amplitude and so on) and in general the effects started to accumulate from 24 h and lasted throughout the exposure. The behavior impairments were transgenerational with varying patterns, amongst the head thrash and body bend responded most sensitively though the responses gradually declined across generations. Arsenic exposure inhibited the growth (body length, body width, and body area) in P C. elegans from 24 h to 60 h, however there was no difference between treatments groups and the control at 72 h. Arsenic led to a dose-dependent degeneration of dopaminergic neurons in C. elegans, and inhibition of BAS-1 and CAT-2 expressions. The expressions of GCS-1, GSS-1, and SKN-1 were induced by arsenic exposure. Overall, chronic arsenic exposure impaired the behaviors and there were transgenerational effects. The head thrash and body bend responded most sensitively. Arsenic induced behavioral disorders might be attributed to degeneration of dopaminergic neurons which was associated with oxidative stress.


Assuntos
Arsênico/toxicidade , Caenorhabditis elegans/fisiologia , Poluentes Químicos da Água/toxicidade , Animais , Caenorhabditis elegans/efeitos dos fármacos , Proteínas de Caenorhabditis elegans/metabolismo , Transtornos Mentais , Estresse Oxidativo/efeitos dos fármacos
15.
J Clin Hypertens (Greenwich) ; 22(2): 234-242, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31944554

RESUMO

The purpose of this study was to investigate the prognostic properties of different BP measurements for renal function decrement and early chronic kidney disease (CKD) in community-dwelling populations with normal renal function at baseline. A total of 1426 participants were included and followed for a median of 4.8 years (interquartile range, 4.5-5.2), and central hemodynamic profile and estimated glomerular filtration rate (eGFR) were evaluated. One main outcome was the rapid eGFR decline defined as a decline in eGFR of greater than 3 mL/min per 1.73 m2 per year; the other was the new incidence of CKD. At the end of follow-up, mean eGFR decreased from 93.39 ± 13.46 mL/min per 1.73 m2 to 85.72 ± 14.81 mL/min per 1.73 m2 , and the incidence of rapid eGFR decline and CKD were 20.7% and 5.6%, respectively. In multivariate linear regression analysis, central pulse pressure (PP), age, fasting blood glucose, and concentration of homocysteine were independent determinants of the change in renal function. Not only in the prediction of rapid eGFR decline but also in the incident of CKD, baseline central PP was the only BP component that consistently independently associated with both outcomes after adjustment for various confounders. When compared with subjects in the lowest quartile of central PP, those in the highest quartile demonstrated a significantly increased risk of CKD (hazard ratio [HR], 1.57; 95% confidence interval [CI], 1.08-2.96; P = .006). The study showed that central PP emerged as an independent predictor of the decline in renal function.

16.
Clin Exp Hypertens ; 42(5): 420-427, 2020 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31760826

RESUMO

Background: Honey has been shown to have multiple positive effects on human health. However, data on the associations of honey consumption with prehypertension are scarce. The aim of this study was to investigate whether honey consumption is associated with prehypertension in a Chinese population. Method: A cross-sectional study was conducted in 4,561 individuals aged ≥40 years. A validated 100-item semi-quantitative food frequency questionnaire was used to assess honey consumption. Blood pressure was measured at least twice by trained nurses. Multiple logistic regression models were used to explore the associations between honey consumption and prehypertension. Results: After adjustment for potential confounders, the odds ratios and 95% confidence intervals of prehypertension across increasing frequency of honey consumption were 1.00 (reference) for almost never, 1.17 (0.96, 1.41) for ≤6 times/week, and 1.25 (0.86, 1.84) for ≥7 times/week in men (P for trend = 0.09); 1.00 (reference) for almost never, 0.76 (0.62, 0.92) for ≤6 times/week, and 0.84 (0.63, 1.12) for ≥7 times/week in women (P for trend = 0.055), respectively. Conclusion: Our results showed that light-to-moderate intake of honey was associated with lower prevalence of prehypertension in women, but not men. Future studies are required to confirm these associations.

17.
Age Ageing ; 49(2): 233-238, 2020 02 27.
Artigo em Inglês | MEDLINE | ID: mdl-31746329

RESUMO

BACKGROUND: although handgrip strength (HGS) is considered an excellent predictor of morbidity and mortality, there are few reference data available, especially across life from young to old populations. OBJECTIVE: to investigate the reference values and determinants for HGS in a large Chinese adult population. DESIGN: this cross-sectional study used data from the Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study ranging from 2013 to 2017. SETTING AND SUBJECTS: in total, 37,707 Chinese adults aged 18-93 years with measures of HGS were included. METHODS: HGS was measured using a handheld digital dynamometer. The percentile distribution of HGS, as well as mean (standard deviation) values of HGS, was calculated according to sex and age categories. The Pearson's or Spearman's correlation coefficient and multiple linear regression were also used. RESULTS: the peak mean value of HGS was 45.2 ± 6.88 kg in men and 26.8 ± 4.65 kg in women. Different reference values for each sex and age category are present. The prevalence of low HGS was 7.69% in men and 6.46% in women. Multiple regression analysis showed that almost 72.5% of HGS variability can be explained by sex, age, height and weight. CONCLUSIONS: the HGS reached peak at 40 years old, maintained or slightly lowered between ages 40 and50 and then start an accelerated decline after 50 years old. Reference values of HGS should be stratified by sex and age group. HGS variability can be largely explained by sex, age, height and weight.

18.
Mol Med Rep ; 21(1): 371-378, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31746381

RESUMO

As a novel anti­inflammatory cytokine of the interleukin (IL)­1 family, IL­37 protects the human body from diseases characterized by excessive inflammation. The pathologic process of hyperhomocysteinemia (hHcy) is accompanied by persistent inflammation. However, little is known regarding the role of IL­37 in hHcy. In the present study, the levels of cytokines including IL­37, IL­1ß, IL­6 and tumor necrosis factor­α in the supernatant were detected by ELISA. mRNA and protein expression were detected by Reverse transcription­quantitative PCR and western blotting, respectively. LDH level was determined by ELISA and the cell viability was detected through CCK­8 kit. In the present study, mean serum IL­37 levels of patients with hHcy were 32.3% lower than those of controls (P<0.01). In peripheral blood mononuclear cells (PBMCs) from patients with hHcy, mean IL­37 mRNA expression was 73.5% lower (P<0.01) and IL­37 protein expression was 77.7% lower compared with that of healthy controls (P<0.01). Furthermore, the results demonstrated that exogenous homocysteine (Hcy) stimulation markedly downregulated the mRNA and protein expression levels of IL­37 in PBMCs in vitro. In 293T cells, overexpression of IL­37 restored the cell viability impaired by Hcy, and reduced the release of lactate dehydrogenase and the proinflammatory cytokines IL­1ß, IL­6 and tumor necrosis factor­α. In conclusion, IL­37 was downregulated by Hcy in vivo and in vitro, and IL­37 exhibited a protective role against cell injury induced by Hcy.

19.
Nutrition ; 71: 110562, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31809956

RESUMO

OBJECTIVE: Previous studies have demonstrated that nutritional status is associated with non-alcoholic fatty liver disease (NAFLD). Meanwhile, subclinical inflammation is associated with the prevalence of NAFLD. To our knowledge, however, no study has investigated the intermediary effect of inflammation on the association between dietary pattern and NAFLD. Thus, the aim of this case-control study was to explore the intermediary effect of inflammation on the association between dietary patterns and NAFLD. METHODS: Using the propensity score matching method, we generated 2043 cases and 2043 controls. Dietary intake was assessed using a valid self-administered food frequency questionnaire. Major dietary patterns in the population were derived by factor analysis. Reduced rank regression with leukocyte count as a response variable was used to derive an inflammatory pattern. NAFLD was diagnosed by liver ultrasonography and drinking history. The association between dietary patterns and NAFLD was tested using multiple conditional logistic regression analysis. RESULTS: Three major dietary patterns were derived by factor analysis: sweet pattern, animal foods pattern, and traditional pattern. Compared with participants in the lowest quartile of the animal foods pattern, the odds ratio (OR; 95% confidence interval [CI]) of NAFLD in the highest quartile was 1.30 (95% CI, 1.09-1.55). After adjustment of inflammation status, the OR was weaker (OR, 1.23; 95% CI, 1.03-1.48), albeit significant. Compared with the participants in the lowest quartile of inflammatory pattern, the OR of NAFLD in the highest quartile was 1.52 (95% CI, 1.28-1.81). CONCLUSION: The present data suggested that inflammation may mediate the association between dietary patterns and NAFLD.

20.
Mol Divers ; 24(1): 21-30, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30796639

RESUMO

The dried rhizome of Musa basjoo Sieb. et Zucc. is Rhizoma Musae. It has been used to treat diabetes in Miao medicine in China. Lupenone was isolated from Rhizoma Musae and has good anti-diabetic activity. Its mechanism of action is unclear. Diabetes is a chronic low-level systemic inflammatory disease, and lupenone has anti-inflammatory activity, but the underlying mechanism is not fully elucidated. In this study, we aimed to construct the drug-target biologic network and predict the anti-inflammatory mechanism of lupenone. The network-based pharmacologic analysis platform was used to identify the target proteins related to inflammation. Furthermore, the effects of lupenone on acute, subacute and diabetic pancreatic inflammation were evaluated. The "component-target-disease" network was constructed using Cytoscape. Lupenone could regulate transcription factor p65, NF-kappa-B inhibitor alpha, transcription factor AP-1, NF-kappa-B essential modulator, nuclear factor NF-kappa-B p105 subunit, epidermal growth factor receptor, hypoxia-inducible factor 1-alpha and other proteins related to the PI3K-Akt, Toll-like receptor and NF-kappa B signaling pathways. In addition, lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1ß and IFN-γ levels in the pancreas of diabetic rats. The above results provide strong support for studying the molecular mechanism of lupenone in the treatment of diabetes from the perspective of anti-inflammation.

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