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1.
Ear Nose Throat J ; : 1455613221140280, 2022 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-36373511

RESUMO

BACKGROUND: To assess whether specific selective neck dissection (SND) with involved levels is a feasible treatment for isolated regional failure in nasopharyngeal carcinoma (NPC) after radiation. MATERIAL AND METHODS: Between January 2011 and December 2019, a total of 46 patients were assigned to undergo SND in the Department of Head and Neck Surgery at our center. The dissection extent of specific SND usually only involved levels of lymph node sites for isolated regional failure; in addition, lesions of level II or III involved removing both level II and III lymph nodes. The patients' clinical, MRI and pathological characteristics, overall survival (OS), disease-free survival (DFS) and regional-free survival (RFS) were evaluated and analyzed. RESULTS: Level II was the most commonly involved cervical nodal region in 28 neck dissection specimens (54.9%), followed by level III with positive nodes in 11 specimens (21.6%). Eleven patients (34.8%) had post-SND locoregional recurrence without distant metastasis. Of the patients, 7 patients (30.4%) had regional recurrence, and only one patient (2.8%) had lymph node recurrence on the side of SND. In addition, 8 patients (17.4%) had post-SND distant metastasis. The OS, DFS, and RFS of the patients were 76.1%, 58.7%, and 69.6%, respectively, at 3 years. The OS, DFS, and RFS values of patients who underwent SND were similar to those of patients who underwent comprehensive neck dissection (CND) and/or SND in published articles. CONCLUSION: Specific SND was shown to be an effective and feasible treatment for isolated regional failure in NPC.

2.
Front Oncol ; 12: 950418, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36387243

RESUMO

Background: Peritoneal sarcomatosis (PS) could occur in patients with retroperitoneal sarcomas (RPS). This study aimed to expand the understanding of PS on its characteristics and prognostic role, and develop a nomogram to predict its occurrence preoperatively. Methods: Data of 211 consecutive patients with RPS who underwent surgical treatment between 2011 and 2019 was retrospectively reviewed. First, the clinicopathological characteristics of PS were summarized and analyzed. Second, the disease-specific survival (DSS) and recurrence-free survival (RFS) of patients were analyzed to evaluate the prognostic role of PS. Third, preoperative imaging, nearly the only way to detect PS preoperatively, was combined with other screened risk factors to develop a nomogram. The performance of the nomogram was assessed. Results: Among the 211 patients, 49 (23.2%) patients had PS with an incidence of 13.0% in the primary patients and 35.4% in the recurrent patients. The highest incidence of PS occurred in dedifferentiated liposarcoma (25.3%) and undifferentiated pleomorphic sarcoma (25.0%). The diagnostic sensitivity of the preoperative imaging was 71.4% and its specificity was 92.6%. The maximum standardized uptake value (SUVmax) was elevated in patients with PS (P<0.001). IHC staining for liposarcoma revealed that the expression of VEGFR-2 was significantly higher in the PS group than that in the non-PS group (P = 0.008). Survival analysis (n =196) showed significantly worse DSS in the PS group than in non-PS group (median: 16.0 months vs. not reached, P < 0.001). In addition, PS was proven as one of the most significant prognostic predictors of both DSS and RFS by random survival forest algorithm. A nomogram to predict PS status was developed based on preoperative imaging combined with four risk factors including the presentation status (primary vs. recurrent), ascites, SUVmax, and tumor size. The nomogram significantly improved the diagnostic sensitivity compared to preoperative imaging alone (44/49, 89.8% vs. 35/49, 71.4%). The C-statistics of the nomogram was 0.932, and similar C-statistics (0.886) was achieved at internal cross-validation. Conclusion: PS is a significant prognostic indicator for RPS, and it occurs more often in recurrent RPS and in RPS with higher malignant tendency. The proposed nomogram is effective to predict PS preoperatively.

3.
Front Surg ; 9: 956384, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36157408

RESUMO

The outcomes of patients with primary retroperitoneal sarcoma (RPS) are significantly superior to those with recurrence. En bloc resection of tumor and adjacent organs is recommended in primary RPS. However, whether en bloc resection of tumor and adjacent organs can benefit recurrent patients or some recurrent patients is unclear. We compared the outcomes of patients with primary RPS, first recurrence (RPS-Rec1), and ≥2 recurrences (≥RPS-Rec2) to evaluate the value and criteria for en bloc resection of tumor and adjacent organs in recurrent cases. We evaluated the safety of en bloc resection of tumor and adjacent organs by assessing operation time, blood loss volume, postoperative morbidities (POM), and efficacy by comparing local recurrence and peritoneal metastasis (LR-PM), distant metastasis, progression-free survival (PFS), and overall survival (OS). A total of 101, 47, and 30 patients with primary RPS, RPS-Rec1, and ≥RPS-Rec2 were included, respectively. Recurrent RPS invaded more adjacent organs and surrounding fat tissue than primary RPS. The operation time, amount of blood loss, incidence of grade III-V POM, LR-PM rate, PFS, and OS in the RPS-Rec1 group were similar to those of the primary group, both of which were significantly superior to those of the ≥RPS-Rec2 group. Macroscopically incomplete resection and high-grade RPS rather than first recurrence were independent risk factors for LR-PM, PFS, and OS. In conclusion, the safety and efficacy of en bloc resection of tumor and adjacent organs in RPS-Rec1 were comparable with those in primary RPS but significantly superior to those of ≥RPS-Rec2. For RPS-Rec1, comparable outcomes to patients with primary RPS can be achieved, particularly in those in whom a macroscopically complete resection is achieved.

4.
Int J Mol Sci ; 23(17)2022 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-36077199

RESUMO

Ultraviolet-C (UV-C) radiation significantly impacts living organisms. UV-C radiation can also be used as a pest management tool. Therefore, this study was designed to investigate the effect of UV-C radiation on the physiology and gene expression level of Plutella xylostella, a destructive vegetable pest. Results showed that, after exposure to UV-C radiation for 3, 6, 12, and 24 h, the activity of SOD (superoxide dismutase) and CAT (catalase) of P. xylostella increased, while the activity of PPO (polyphenol oxidase), POD (peroxidase), AChE (acetylcholinesterase), CarE (carboxylesterase), and ACP (acid phosphatase) decreased with increased exposure time. Correlation coefficient analyses indicated that the activity of CAT correlated positively, while PPO and CarE correlated negatively, with exposure time. Gene regulation analysis via qRT-PCR confirmed a significant increase in regulation in CAT, CarE, and PPO-related genes. We also investigated the effect of UV-C exposure on the virulence of Cordyceps fumosorosea against P. xylostella. Here, results indicated that when the fungal treatment was applied to larvae before UV-C radiation, the virulence of C. fumosorosea was significantly reduced. However, this decline in virulence of C. fumosorosea due to UV-C exposure remained only for one generation, and no effect was observed on secondary infection. On the other hand, when larvae were exposed to UV-C radiation before fungal application, the mortality rate significantly increased as the exposure time to UV-C radiation increased. From the current study, it could be concluded that UV-C exposure suppressed the immunity to P. xylostella, which later enhanced the virulence of entomopathogenic fungi. Moreover, the study also suggested that UV irradiation is an effective pest management tool that could be incorporated into pest management strategies, which could help reduce pesticide application, be economically beneficial for the farmer, and be environmentally safe.


Assuntos
Cordyceps , Mariposas , Acetilcolinesterase , Animais , Larva/microbiologia , Mariposas/microbiologia
5.
Huan Jing Ke Xue ; 43(3): 1323-1331, 2022 Mar 08.
Artigo em Chinês | MEDLINE | ID: mdl-35258196

RESUMO

Fugitive dust poses an important contribution to urban air particulate matter in China. To further improve the level of dust pollution prevention and control, the emission and contribution characteristics of urban fugitive dust were summarized; the main causes of dust pollution were analyzed; and the key links, key indicators, and main measures for prevention and control were clarified, so as to further improve the concept of "accurate dust control." Among all types of fugitive dust sources, road dust and construction dust were the main emission and contribution sources, among which road dust was more prominent. Production activities, vehicle disturbances, and wind erosion were the main dust-generating links of various dust sources. Silt loading was taken as the key control index for road dust prevention and control, whereas silt loading and bare soil (or material) areas were taken as the key control index for construction and other dust sources. Around the key indicators, three main ways to control the road dust and six main measures to control the construction and other dust sources were defined. In addition, some suggestions on the necessary supporting measures for dust control were put forward, so as to provide a comprehensive and beneficial reference for the practical application of dust control in Chinese cities.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Poluição do Ar/prevenção & controle , China , Poeira/análise , Monitoramento Ambiental , Material Particulado/análise
6.
Mol Med Rep ; 25(2)2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35014686

RESUMO

Long non­coding RNAs can regulate the malignant tumor phenotype either as tumor suppressors or oncogenes. The present study investigated the underlying mechanism of LINC00238 in liver cancer. LINC00238 was identified as a downregulated molecule in The Cancer Genome Atlas liver hepatocellular carcinoma dataset through Gene Expression Profiling Interactive Analysis software. Through gain­ and loss­of­function experiments, LINC00238 was confirmed as a tumor suppressor that could not only decrease cell viability, migration and invasion in vitro, but also tumorigenesis and tumor metastasis in vivo. By cytoplasmic and nuclear RNA isolation, LINC00238 was confirmed to be predominantly cytoplasmic. Mechanistically, RNA pull­down assays showed that LINC00238 sponged microRNA (miR)­522 and then reversed the inhibitory effects on two downstream targets, secreted frizzled related protein 2 and dickkopf1. Collectively, LINC00238 was identified as a tumor suppressor that acts via sponging miR­522 followed by silencing of downstream targets, suggesting that LINC00238 may have a key role in suppressing the malignant phenotype of liver cancer cells.


Assuntos
Carcinoma Hepatocelular/genética , Carcinoma Hepatocelular/metabolismo , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/metabolismo , MicroRNAs/metabolismo , RNA Longo não Codificante/genética , RNA Longo não Codificante/metabolismo , Animais , Carcinogênese/genética , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/patologia , Linhagem Celular , Movimento Celular/genética , Proliferação de Células/genética , Sobrevivência Celular/genética , Galinhas , Regulação para Baixo , Regulação Neoplásica da Expressão Gênica , Genes Supressores de Tumor , Humanos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patologia , MicroRNAs/genética , Modelos Biológicos , Fenótipo , Prognóstico
7.
Updates Surg ; 74(3): 1157-1163, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32602011

RESUMO

Complete resection for retroperitoneal sarcoma (RPS) involving major vessels frequently requires vascular resection and reconstruction. The use of artificial grafts often leads to postoperative vascular graft infection (VGI), which usually requires reoperation and sometimes leads to death. In the present study, the data of RPS patients who underwent contralateral iliac artery (IIA) transposition for reconstruction of the common iliac artery (CIA) after RPS resection from 2015-2019 were retrospectively analyzed. Clinical, intraoperative, and postoperative outcomes were described. Contralateral IIA transposition was performed to reconstruct the CIA after segmental resection in three patients. All patients underwent concomitant organ resection. Colon resection was performed for all patients, nephrectomy was performed for two patients, and segmental resection of the left ureter with transurethral ureterostomy was performed for one patient. Complete resection was achieved in all patients, and microscopic tumor infiltration to the CIA was observed in all patients (tunica adventitia: 2, tunica media: 1). No major complications occurred during the hospital stay. During the follow-up period (6.0-29.1 months), one patient died from tumor recurrence, and the other two patients did not have any evidence of recurrence or metastatic disease at the latest follow-up. The level of lower limb function was favorable (MSTS93 scores: 28-30). The pelvic organ functions, including bowel, bladder, and sexual functions, were not impaired in any of the patients. This novel technique in which contralateral IIA transposition is performed to reconstruct the CIA after RPS resection is simple and reliable and may be a good alternative to artificial grafts.


Assuntos
Implante de Prótese Vascular , Neoplasias Retroperitoneais , Sarcoma , Aorta Abdominal/cirurgia , Implante de Prótese Vascular/métodos , Humanos , Artéria Ilíaca/cirurgia , Neoplasias Retroperitoneais/cirurgia , Estudos Retrospectivos , Sarcoma/cirurgia , Stents , Resultado do Tratamento
8.
Ear Nose Throat J ; : 1455613211058114, 2021 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-34814772

RESUMO

OBJECTIVE: The present study was designed to investigate whether acellular dermal matrix (ADM) grafts could prevent Frey's syndrome (FS) and improve esthetic scores following parotidectomy. METHODS: From January 2015 to December 2019, 175 patients underwent parotidectomy. We divided the patients into two groups: the ADM group and the control group. We included in each group 30 patients according to a propensity score matched analysis. RESULTS: FS was subjective in 1 patient (3%) from the ADM group and 9 patients (30%) from the control group (P=0.015). Patients in the ADM group had a subjective esthetic score of 6.1 + 1.7 compared with 5.2 + 1.7 in the control group. The subjective esthetic score for patients in the ADM group was higher than that for patients in the control group (P =0.040). CONCLUSION: The present clinical study suggests that ADM grafts are effective in preventing FS and improving esthetic scores after parotidectomy.

9.
Oxid Med Cell Longev ; 2021: 2060288, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34336086

RESUMO

Ultraviolet (UV) radiation significantly affects insect life and, as a result, has been widely used to control different invertebrate pests. The current results demonstrate that when Bemisia tabaci first instar nymphs are exposed to UV-A light for 12, 24, 48, and 72 h, their developmental and biological parameters are negatively affected by UV-A exposure; the effect increased with an increase in exposure time. We hypothesized that UV-A light is compatible with other biological control agents. Results showed that when the entomopathogenic fungus Cordyceps fumosorosea was applied to third instar nymphs of B. tabaci previously exposed to UV-A light, the LC50 was 3.4% lower after 72 h of exposure to UV-A light compared to the control. However, when the fungus was exposed to UV-A light, its virulence decreased with an increase in UV-A exposure time. The parasitism rate of Encarsia formosa against 24 h UV-A-exposed third instar nymphs of B. tabaci increased while the adult emergence from parasitized nymphs was not affected after UV-A light exposure. Parasitism rate was significantly reduced however following E. formosa exposure to UV-A light; but again, adult emergence was not affected from parasitized nymphs. The percentage mortality of E. formosa increased with increasing exposure time to UV-A light. The enzyme activity of SOD, CAT, GST, and AChE and the energy reserve contents were negatively affected due to UV-A exposure. Collectively, this study has demonstrated that UV-A light significantly suppresses the immune system of B. tabaci and that UV-A light is compatible with other biological control agents if it is applied separately from the biological agent.


Assuntos
Hemípteros/química , Raios Ultravioleta , Terapia Ultravioleta/métodos , Animais
10.
Cancer Manag Res ; 13: 6157-6167, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34385843

RESUMO

BACKGROUND: Previous studies have shown that nutrition and systemic inflammation plays an essential role in the development of soft tissue sarcoma. However, few studies have explored the association of clinicopathologic features and local recurrence with nutritional and inflammatory markers in retroperitoneal liposarcoma (RPLS). This study sought to evaluate the prognostic value of the preoperative nutritional and inflammatory markers for local recurrence-free survival (LRFS) among surgical RPLS patients. METHODS: The study included 111 RPLS patients who underwent surgery between May 2010 and June 2019 at the Peking University Cancer Hospital Sarcoma Center. Time-dependent receiver operating characteristic (time-ROC) curve analysis was conducted to evaluate the ability of markers to predict LRFS. The associations of the CONUT-FAR score with clinicopathological variables and LRFS were evaluated. RESULTS: In the time-ROC curve analysis, the CONUT-FAR score was superior to other nutritional and inflammatory markers in predicting LRFS. The CONUT-FAR score was the only nutritional and inflammatory marker that independently predicted LRFS in the multivariate analysis, and patients with a high CONUT-FAR score (> 11) showed significantly decreased LRFS. Although the CONUT-FAR score failed to discriminate patients with low grade (G1) (p = 0.327) or undergoing incomplete (R2) resection (p = 0.072), it stratified patients with high grade (G2 and G3) or undergoing complete resection (R0/R1) into subgroups with significantly distinct LRFS (p < 0.001). The CONUT-FAR score also showed good clinical utility among patients with different clinical characteristics. CONCLUSION: The preoperative CONUT-FAR score reflects both nutritional and inflammatory factors and is an effective predictor of LRFS for surgical RPLS patients.

11.
Front Oncol ; 11: 673877, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34221992

RESUMO

Pembrolizumab, an immune checkpoint inhibitor (ICI) approved for advanced non-small cell lung cancer (NSCLC) treatment, has shown superior survival benefits. However, pembrolizumab may lead to severe immune-related adverse events (irAEs), such as checkpoint inhibitor-related pneumonitis (CIP). The routine treatment of CIP was based on systemic corticosteroids, but the therapies are limited for patients who are unsuitable for steroid therapy. Here, we present the first successful treatment of nintedanib for pembrolizumab-related pneumonitis in a patient with advanced NSCLC.

12.
Sci Prog ; 104(2): 368504211028367, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34191640

RESUMO

This study aimed to review our experience with the clinical characteristics and management of deep neck infections (DNIs) and determine the changing trends of their characteristics over time in southern China. Patients diagnosed with a DNI between January 2009 and December 2018 were screened retrospectively for their demographic characteristics, etiology of infection, site of infection, microbiology, treatment, and complications. In total, 127 patients were included: 41 (32.3%) were treated between 2009 and 2013 (group A), and 86 (67.7%) were treated between 2014 and 2018 (group B). The most common site of infection in group A was the parapharyngeal space (15 patients, 36.6%), while that in group B involved multiple spaces (36 patients, 41.9%). The leucocyte count (×109 cells/L) was 13.23 ± 4.19 in group A and 16.04 ± 4.33 in group B (p < 0.001). Streptococcus viridans was the most common bacteria in both groups. The mean hospital stay was 21.46 ± 33.09 days in group A and 10.44 ± 6.19 days in group B. The rate of diabetes mellitus (DM) in group A was lower than that in group B (8/41 and 33/86, respectively; p = 0.034). Airway obstruction was the most common complication in both groups. DNIs are more likely to show multi-space involvement, affect more DM patients, and be associated with higher leucocyte counts over time. We infer that the duration from morbidity to admission and that from admission to operation play roles in the successful management of DNIs, possibly causing fewer complications, lower mortality rates, and shorter hospital stays. DM patients require increased attention.


Assuntos
Infecções Bacterianas , Diabetes Mellitus , Bactérias , Infecções Bacterianas/diagnóstico , Infecções Bacterianas/tratamento farmacológico , Infecções Bacterianas/microbiologia , Dor no Peito/complicações , Humanos , Tempo de Internação , Pescoço/microbiologia , Estudos Retrospectivos
13.
Huan Jing Ke Xue ; 42(6): 2740-2747, 2021 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-34032073

RESUMO

Treatment of industrial atmospheric emission sources is an important way to improve air quality, but accurate pollution control remains still an urgent challenge. Taking Xiqing District of Tianjin as an example, based on the second national pollution source census, this study carried out a quantitative evaluation of the pollutant emission performance of industrial enterprises and explored the significance, feasibility, and challenges facing emission performance evaluation. The results show that the emission performance of various industries in Xiqing District vary greatly. The pollutant emission performance level is closely related to an industry's own attributes, development scale, and management level. On the whole, the emission performance level of industries with high production process emission coefficients and a high proportion of small and medium-sized enterprises (such as furniture manufacturing, the metal products industry, ferrous metal smelting, and the rolling processing industry) is worse, while the emission performance of high-end industries represented by computer communication and other electronic equipment manufacturing and automobile manufacturing is generally better. The emission performance of different enterprises in the same industry also varies greatly. For example, the 11 enterprises with the worst performance in the metal machinery manufacturing industry only contributed 0.06% of industrial output yet their PM emission contribution reached 8.50%. The 19 worst-performing enterprises in the rubber and plastic industry contributed 4.76% of industrial output yet their VOCs emissions accounted for 43.59% of the total. At the same time, this study presents an emissions reduction plan according to the relevant technical guidelines of the Ministry of Ecology and Environment. Based on this, the cost of emissions reduction could be cut by as much as 90% when the pollutant emissions reductions of the same scale are reduced. The gap in the pollutant emissions performance of various industries and enterprises, the incongruity between economic benefits and environmental costs, and the important guiding role of emission performance evaluation for emissions reductions demonstrate the necessity of performance evaluation. Overall, this research shows that pollutant emission performance evaluation can effectively support macro-industrial structure adjustment and the environmental governance of meso-micro industrial enterprises, providing an important reference for pollution control interventions.

14.
Int J Med Sci ; 17(18): 3073-3081, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33173428

RESUMO

Patient-derived xenograft (PDX) models are effective preclinical cancer models that reproduce the tumor microenvironment of the human body. The methods have been widely used for drug screening, biomarker development, co-clinical trials, and personalized medicine. However, the low success rate and the long tumorigenesis period have largely limited their usage. In the present studies, we compared the PDX establishment between hepatocellular cancer (HCC) and metastatic liver cancer (MLC), and identified the key factors affecting the transplantation rate of PDXs. Surgically resected tumor specimens obtained from patients were subcutaneously inoculated into immunodeficient mice to construct PDX models. The overall transplantation rate was 38.5% (20/52), with the HCC group (28.1%, 9/32) being lower than MLC group (56.2%, 9/16). In addition, HCC group took significantly longer latency period than MLC group to construct PDX models. Hematoxylin and eosin staining results showed that the histopathology of all generations in PDX models was similar to the original tumor in all three types of cancer. The transplantation rate of PDX models in HCC patients was significantly associated with blood type (P=0.001), TNM stage (P=0.023), lymph node metastasis (P=0.042) and peripheral blood CA19-9 level (P=0.049), while the transplantation rate of PDX models in MLC patients was significantly associated with tumor size (P=0.034). This study demonstrates that PDX models can effectively reproduce the histological patterns of human tumors. The transplantation rate depends on the type of original tumor. Furthermore, it shows that the invasiveness of the original liver cancer affects the possibility of its growth in immunodeficient mice.


Assuntos
Carcinoma Hepatocelular/patologia , Neoplasias Colorretais/patologia , Neoplasias Hepáticas/secundário , Fígado/patologia , Microambiente Tumoral , Animais , Carcinoma Hepatocelular/cirurgia , Neoplasias Colorretais/cirurgia , Feminino , Hepatectomia , Humanos , Fígado/cirurgia , Neoplasias Hepáticas/cirurgia , Masculino , Camundongos , Pessoa de Meia-Idade , Ensaios Antitumorais Modelo de Xenoenxerto/métodos
15.
BMC Urol ; 20(1): 177, 2020 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-33138801

RESUMO

BACKGROUND: Ureteric stricture is a common and salvaging complications after renal transplantation. Two treatment methods are usually used, retrograde ureteral stent placement and percutaneous nephrostomy. The former has a higher failure rate, the latter has a great risk. Therefore, a safe and reliable treatment is needed. CASE PRESENTATION: A technique of retrograde insertion of ureteral stent was established, which was applicable in three transplant recipients with post-transplant ureteral stenosis, and the data was retrospectively recorded. The patients are 2 men and 1 woman, ages 44, 27 and 32 years. These patients underwent a total of five times of retrograde insertion of ureteral stent between 2018 and 2019. None of these patients had any postoperative complication, but all patients had complete recovery from oliguric status within two weeks. CONCLUSIONS: The retrograde ureteric stent insertion by percutaneous suprapubic access to the bladder (RUS-PSAB) was demonstrated feasibility and safety in a case series with short-term follow-up. However, larger prospective studies are needed.


Assuntos
Transplante de Rim , Complicações Pós-Operatórias/cirurgia , Implantação de Prótese/métodos , Stents , Ureter/cirurgia , Obstrução Ureteral/cirurgia , Adulto , Constrição Patológica/cirurgia , Feminino , Humanos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos , Bexiga Urinária , Procedimentos Cirúrgicos Urológicos/métodos
16.
Front Oncol ; 10: 548789, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33072576

RESUMO

BACKGROUND: En bloc resection of retroperitoneal sarcoma (RPS) with adjacent organs such as pancreatic head and duodenum is challenging for surgeons. This mono-institutional study aims to evaluate the feasibility, safety, and outcome of performing pancreaticoduodenectomy (PD) during RPS resection. METHODS: The clinical data of RPS patients who underwent PD at the Sarcoma Center of Peking University Cancer Hospital from January 2011 to December 2019 was collected and analyzed. RESULTS: Twenty-seven patients out of a total of 264 surgically treated RPS underwent PD. The main pathological subtype was liposarcoma. All patients received concomitant resection of a median of three additional organs (range: 1-5), including 11 patients (40.7%) who underwent inferior vena cava resection and one patient who underwent segmental superior mesenteric-portal vein resection. Microscopic tumor infiltration to the duodenum or pancreas was observed in 81.5% of patients. Major complications occurred in 40.7% of patients; the reoperation rate was 22.2%. One patient (3.7%) died from liver abscess postoperatively. During a median follow-up of 18.9 months, 15 patients (55.6%) developed locally recurrent disease; two patients (7.4%) also had pulmonary metastases additionally. Twelve patients (44.4%) died from local relapse eventually. CONCLUSION: PD during RPS resection is feasible, and it may be necessary to achieve complete resection. However, considering the complexity and risk, it should be performed by an experienced surgical team. The long-term survival benefit of this procedure should be verified by further large-scale multi-institutional studies.

17.
Huan Jing Ke Xue ; 41(10): 4455-4461, 2020 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-33124377

RESUMO

As flue gas desulfurization (FGD) was one of the most important purification processes of coal-fired boilers, we selected four boilers, which were equipped with wet limestone, furnace calcium injection, ammonia-based, and double-alkali FGDs, to research the influence of FGDs on the flue particulate matter (PM). The flue PM before and after the FGD were sampled using laboratory resuspension and dilution tunnel sampling methods, respectively, and the PM was analyzed for its chemical composition (i.e., ions, elements, and carbon). The results showed that the types of desulfurizers could influence the composition of the flue PM. After passing through the wet limestone, ammonia-based, and double-alkali FGDs, the proportion of Ca, NH4+, and Na in PM2.5 increased from 5.1% to 24.8%, from 0.8% to 7.3%, and from 0.9% to 1.7%, respectively. The influence of wet and dry FGDs on the flue PM were different. The fraction of ions in the PM emitted from the wet FGD were higher than those from the dry FGD. The proportion of SO42- in the flue PM2.5 increased from 2.0% and 6.7% to 9.6% and 11.9% using the wet limestone and ammonia-based FGDs, respectively, and Cl- increased from 0.4% and 1.2% to 3.8% and 5.2%. In addition, the amount of heavy metals (e.g., Cr, Pb, Cu, Ti, and Mn) in PM2.5 declined after the wet FGDs. The PM2.5 emitted from the dry FGD boiler was richer in crustal elements, such as Al, Si, and Fe, than that from the wet FGDs. The wet FGDs also effected the carbonaceous components of the flue PM. After passing through the wet limestone and ammonia-based FGDs, the proportion of elemental carbon in the flue PM2.5 decreased from 6.1% to 0.9% and from 3.6% to 0.7% respectively, but the organic carbon content did not decrease.

18.
Technol Cancer Res Treat ; 19: 1533033820948183, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32940552

RESUMO

BACKGROUND: The present study was designed to investigate the presence or absence of calcification and whether calcification size affect the diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in predicting the benign or malignant nature of thyroid nodules. MATERIAL AND METHODS: From May 2014 to April 2019, 445 patients underwent thyroid US and neck CT before thyroid surgery. In each case, US and CT were retrospectively examined by radiologists. We divided the patients into 3 groups according to the type of calcification: no calcification, microcalcification, and macrocalcification. And macrocalcification group divided into rim calcifications and non-rim calcifications groups. We evaluated the diagnostic accuracy of US and CT for differentiating malignant from benign thyroid nodules using histopathological results as a reference standard. RESULTS: In the overall population, adding CT to US resulted in greater sensitivity, lower specificity, and lower accuracy in the prediction of the benign or malignant nature of nodules. In the group with no calcification, US had a significantly greater accuracy than CT and combined US/CT. In the group with macrocalcification, especially in rim calcifications, adding CT to US resulted in greater sensitivity than US, and CT exhibited greater sensitivity and accuracy than US. CONCLUSION: US is superior to CT for the prediction of the benign or malignant nature of nodules in thyroid lesions according to calcification and CT is also currently not recommended as a routine imaging tool for thyroid nodules. However, the superior sensitivity and accuracy of CT in lesions with macrocalcification especially in rim calcifications may enable CT to play a complementary role in identifying benign and malignant nodules.


Assuntos
Cuidados Pré-Operatórios , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/patologia , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/patologia , Tomografia Computadorizada por Raios X , Ultrassonografia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Nódulo da Glândula Tireoide/cirurgia , Tomografia Computadorizada por Raios X/métodos , Ultrassonografia/métodos , Adulto Jovem
19.
Molecules ; 25(8)2020 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-32316104

RESUMO

Multi-target ligand strategies provide a valuable method of drug design. However, to develop a multi-target drug with the desired profile remains a challenge. Herein, we developed a computational method binding-site match maker (BSMM) for the design of multi-target ligands based on binding site matching. BSMM was built based on geometric hashing algorithms and the representation of a binding-site with physicochemical (PC) points. The BSMM software was used to detect proteins with similar binding sites or subsites. In particular, BSMM is independent of protein global folds and sequences and is therefore applicable to the matching of any binding sites. The similar sites between protein pairs with low homology and/or different folds are generally not obvious to the visual inspection. The detection of such similar binding sites by BSMM could be of great value for the design of multi-target ligands.


Assuntos
Biologia Computacional/métodos , Proteínas/química , Sítios de Ligação , Desenho de Fármacos , Ligantes , Modelos Moleculares , Ligação Proteica , Software
20.
Huan Jing Ke Xue ; 40(11): 4764-4773, 2019 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854541

RESUMO

The characteristics of chemical components of particulate matter are good indicators for analyzing sources and causes of pollution. The spatial and temporal distribution characteristics of particulate matter can reflect regional pollution problems in urban development, providing a basic dataset to support effective control of particulate matter sources. We collected PM2.5 and analyzed its concentration and chemical components at eight sites during different seasons. The results indicated that the average concentration of PM2.5 in Wuhan reached 70.7 µg·m-3. The concentration of PM2.5 in winter (103.1 µg·m-3) was significantly higher than that of other seasons, and the lowest concentration was in autumn (52.4 µg·m-3). The concentrations of PM2.5 in Donghu Gaoxin, Zhuankou New Area, and Qingshan Ganghua Station were significantly higher than those at the other sites. The main chemical components in PM2.5 were OC and SO42-, accounting for 15.4% and 14.2%, respectively. The OC concentration was the highest in winter, whereas SO42-concentration was the highest in summer. The average annual OC/EC ratio was up to 2.80, lower in winter and spring, and higher in summer and autumn. Material reconstruction showed that secondary particles and organic matter (OM) were major substances, accounting for 32.34% and 20.44% of PM2.5 mass, respectively. Coal combustion and vehicle exhaust might be the main contributors to ambient PM2.5. The highest fractions for OM were at the Wujiashan and Donghu Gaoxin sites, whereas the fraction of secondary particles was higher at each site, suggesting that secondary pollution had obvious regional characteristics in Wuhan. Cluster analysis based on the characteristics of chemical components showed that the eight sites were divided into three clusters:1 Hanyang Yuehu, Haze, Donghu Liyuan, and Huangpi sites, where the main characteristics were that the concentrations of components at each point were low; ② Zhuankou New Area and Qingshan Ganghua, which were characterized by higher nitrogen components; and ③ Donghu Gaoxin and Wujiashan, where not only industrial sources were heavily polluted in Wuhan, but also motor vehicles and dust pollution greatly contributed.

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