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1.
J Food Prot ; 2022 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-35020918

RESUMO

This study investigated the ultraviolet (UV) light-induced effect of chitosan-titanium dioxide-silver (CTS-TiO2-Ag) nanocomposite film solution against Penicillium steckii ( ( P. steckii ) , as well as the underlying the physiological mechanism. The results indicated that the longer the UV exposure time, the better the pathogenic inhibition effect. After UV photoinduced treatment for 120 min, the colony diameter of P. steckii was the smallest at 4.85 mm. However, when this process is followed by an 8-h storage period, the conductivity of the P. steckii culture medium reached its highest level at 713 µs/cm. After a 120 h growth period in the same conditions, the lesion diameters and pathogenicity of the mangoes reached 12.61 mm and 41.67%, respectively. Since the cell membrane was severely disrupted, its permeability increased, causing serious intracellular protein and nucleic acid material extravasation. Furthermore, the malondialdehyde (MDA) , catalase (CAT) and superoxide dismutase (SOD) in the   P. steckii reached maximum levels after 8 h of incubation, at 2.1106 µmol/mL, 44.06 U/mL, and 24.67 U/mL respectively. These results indicated significant P. steckii inhibition via the UV light induction of the CTS-TiO 2 -Ag composite film solution.

2.
Magn Reson Med ; 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34985145

RESUMO

PURPOSE: To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. METHODS: We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution. RESULTS: The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution. CONCLUSION: The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.

3.
Dose Response ; 20(1): 15593258211062781, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35069049

RESUMO

Sapindus mukorossi Gaertn is also known as Mu Huanzi, You Huanzi, soap tree, etc. The pericarp of Sapindus mukorossi contains many saponins, which is a type of natural non-ionic surfactant. Its extract has vigorous surface activity and biological activities such as bacteriostasis, oxidation resistance, and free radical scavenging. The Sapindus mukorossi extract is an environmentally friendly washing product that microorganisms can be rapidly decompose in nature without any environmental pollution.This study aims to investigate the effects of E-beam and Co60-γ irradiation on the total saponins content in the crude extract of the S mukorossi. The S mukorossi powder is irradiated with E-beam and Co60-γ ray at doses of 0, 4, 6, 8, 10, and 12 kGy for E-beam and 0, 50, 100, 150, and 200 Gy, respectively, for Co60-γ ray. The changes in the content of total saponins in the crude extract, total detergency, and the bacteriostatic abilities before and after the irradiation were analyzed. The results showed that the content of total saponins in samples irradiated by E-beam was significantly higher than that in non-irradiated samples. The saponins yield was the highest at a radiation dose of 6 kGy, and the detergency and bacteriostatic ability were also the strongest. After low-dose Co6-γ irradiation, the total saponins in the S mukorossi crude extract, and detergency and bacteriostatic ability had no apparent change. Conclusion: E-beam irradiation at a dose of 6 kGy can effectively improve the content of total saponins in the crude extract of S mukorossi powder. In addition, its effects on detergency and bacteriostatic abilities are relatively significant. The findings provide sufficient reference data for the further development of S mukorossi commodities.

4.
Diagn Pathol ; 17(1): 13, 2022 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-35057825

RESUMO

BACKGROUND: STAT3 plays an important role in cervical cancer. LC3B, the most potential molecular biomarker of autophagy that may promote or inhibit cancer progression, can be downregulated by STAT3. However the role of STAT3 in the autophagy of cervical cancer remains unclear. PURPOSE: This study aimed to evaluate the relationship between STAT3 and LC3B in protein level, and verify whether STAT3 promotes proliferation, migration and plate colony formation by inhibiting autophagy of cervical cancer cells through bcl2-beclin1 axis. RESULTS: STAT3 was overexpressed in cervical cancer tissues, and negatively correlated with the expression level of LC3B. STAT3 knockout or knockdown significantly increased the autophagy level and decreased proliferation, migration, plate colony formation and subcutaneous tumorigenesis of cervical cancer cells in vitro and in vivo. STAT3 is known to mediate autophagy through Bcl2-Beclin1 complex. Bcl2 was positively whereas Beclin1 negatively correlated with STAT3 expression, indicating that Bcl2-Beclin1 complex involved in this transition. CONCLUSION: STAT3 may upregulate the autophagy level of cervical cancer cells through the Bcl2-Beclin1 axis. This indicates that STAT3 may be an important prognostic and therapeutic target for cervical cancer.

5.
Eur J Med Chem ; 229: 114081, 2022 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-34992039

RESUMO

Targeted protein degradation using small molecules is an intriguing strategy for drug development. The marine sesterterpene compound MHO7 had been reported to be a potential ERα degradation agent. In order to further improve its biological activity, two series of novel MHO7 derivatives with long side chains were designed and identified as novel selective estrogen receptor down-regulators (SERDs). The growth inhibition activity of the novel SERD compounds were significantly affected by the type and length of the side chain. Most of the derivatives were significantly more potent than MHO7 against both drug-sensitive and drug-resistant breast cancer cells. Among them, compound 16a, with IC50 values of 0.41 µM against MCF-7 cell lines and 9.6-fold stronger than MHO7, was the most potential molecule. A whole-genome transcriptomic analysis of MCF-7 cells revealed that the mechanism of 16a against MCF-7 cell was similar with that of MHO7. The estrogen signaling pathway was the most affected among the disturbed genes, but the ERα degradation activity of 16a was observed higher than that of MHO7. Other effects of 16a were confirmed similar with MHO7, which means that the basic mechanisms of the derivatives are the same with the ophiobolin backbone, i.e. the degradation of ERα is mediated via proteasome-mediated process, the induction of apoptosis and the cell cycle arrest at the G1 phase. Meanwhile, a decrease of mitochondrial membrane potential and an increase of cellular ROS were also detected. Based on these results, as a novel modified ophiobolin derived compound, 16a may warrant further exploitation as a promising SERD candidate agent for the treatment of breast cancer.

6.
Artigo em Inglês | MEDLINE | ID: mdl-35066595

RESUMO

Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) levels were determined in surface water, groundwater and sediments of the Jin River Basin, southeastern China. PFOA was detected in most of the samples, and its concentrations ranged from 0.53 to 8.77 ng/L, 0.26 to 15.1 ng/L and not detected (ND) to 23.9 ng/g in surface water, groundwater and sediments, respectively. Unlike PFOA, the detection frequency of PFOS was lower than 32%, and its concentrations ranged from ND to 2.56 ng/L, ND to 7.01 ng/L, ND to 11.1 ng/g in surface water, groundwater and sediments, respectively. The environmental risk assessment showed that PFOA could pose a high risk to surface water and groundwater, and both PFOA and PFOS posed a high risk to sediments. Moreover, the adults living in the Jin River Basin were at insignificant health risk to exposure to PFOA and PFOS through water consumption.

7.
Int J Endocrinol ; 2022: 9322332, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35047039

RESUMO

Background: Type 2 diabetes (T2D) as a worldwide chronic disease combined with the COVID-19 pandemic prompts the need for improving the management of hospitalized COVID-19 patients with preexisting T2D to reduce complications and the risk of death. This study aimed to identify clinical factors associated with COVID-19 outcomes specifically targeted at T2D patients and build an individualized risk prediction nomogram for risk stratification and early clinical intervention to reduce mortality. Methods: In this retrospective study, the clinical characteristics of 382 confirmed COVID-19 patients, consisting of 108 with and 274 without preexisting T2D, from January 8 to March 7, 2020, in Tianyou Hospital in Wuhan, China, were collected and analyzed. Univariate and multivariate Cox regression models were performed to identify specific clinical factors associated with mortality of COVID-19 patients with T2D. An individualized risk prediction nomogram was developed and evaluated by discrimination and calibration. Results: Nearly 15% (16/108) of hospitalized COVID-19 patients with T2D died. Twelve risk factors predictive of mortality were identified. Older age (HR = 1.076, 95% CI = 1.014-1.143, p=0.016), elevated glucose level (HR = 1.153, 95% CI = 1.038-1.28, p=0.0079), increased serum amyloid A (SAA) (HR = 1.007, 95% CI = 1.001-1.014, p=0.022), diabetes treatment with only oral diabetes medication (HR = 0.152, 95%CI = 0.032-0.73, p=0.0036), and oral medication plus insulin (HR = 0.095, 95%CI = 0.019-0.462, p=0.019) were independent prognostic factors. A nomogram based on these prognostic factors was built for early prediction of 7-day, 14-day, and 21-day survival of diabetes patients. High concordance index (C-index) was achieved, and the calibration curves showed the model had good prediction ability within three weeks of COVID-19 onset. Conclusions: By incorporating specific prognostic factors, this study provided a user-friendly graphical risk prediction tool for clinicians to quickly identify high-risk T2D patients hospitalized for COVID-19.

8.
Artigo em Inglês | MEDLINE | ID: mdl-35055639

RESUMO

Based on activity theory, this paper employed data from the 2013, 2015, and 2018 waves of the China Health and Retirement Longitudinal Survey, and adopted Hierarchical Linear Modeling and longitudinal mediation analysis to explore the temporal variation characteristics of loneliness and the influence of social participation on loneliness in Chinese Older Adults, as well as the mechanism of them. The study found that loneliness among older adults overall was at a moderate level from 2013 to 2018 and increased over time, which may be related to decreasing social participation from year to year. Decreased social participation was associated with increased loneliness over time (ß = -0.060, p < 0.001) and lower social support (ß = 0.109, p < 0.001), which was associated with more loneliness (ß = -0.098, p < 0.001). In addition, social support played a significant mediating role in the realization of social participation in alleviating loneliness. Social participation can not only directly reduce loneliness, but also reduce loneliness by increasing social support.

9.
Chem Biol Interact ; : 109780, 2022 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-34990588

RESUMO

OBJECTIVE: microRNA (miR)-based therapeutic reference has been established and expanded in the treatment of cancers. For this reason, we explored how miR-671-5p regulated tumorigenicity of ovarian cancer (OC) through regulating histone deacetylase 5 (HDAC5) and hypoxia-inducible factor-1α (HIF-1α). METHODS: miR-671-5p, HDAC5 and HIF-1α expression levels were determined in OC clinical tissues. The OC cell line H8910 was screened and transfected with the vector that altered miR-671-5p, HDAC5 and HIF-1α levels. Finally, the proliferation, migration, invasion and apoptosis of the transfected H8910 cells were determined and the role of miR-671-5p and HDAC5 in vivo tumor growth was further discussed. RESULTS: Low miR-671-5p and high HDAC5 and HIF-1α levels were tested in OC tissues. Up-regulating miR-671-5p or down-regulating HDAC5 or HIF-1α suppressed proliferation, migration, invasion and augmented apoptosis of H8910 cells while the silenced miR-671-5p or enhanced HDAC5 caused the opposite consequences. Overexpression of HDAC5 reduced while depletion of HDAC5 enhanced the influence of up-regulated miR-671-5p on OC cell growth. In animal models, suppressing miR-671-5p or promoting HDAC5 encouraged OC tumor growth. CONCLUSION: A summary delineates that miR-671-5p reduces tumorigenicity of OC via suppressing HDAC5 and HIF-1α levels.

11.
Sci Total Environ ; 806(Pt 4): 150951, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34656590

RESUMO

It is very important for air pollution prevention and control to accurately quantify atmospheric environment capacity (AEC) in the planetary boundary layer (PBL). This study developed a high temporal-resolution dynamic multi-box algorithm to estimate PM2.5 AEC with a PBL ceilometer and Doppler wind profile lidar in Beijing City. Compared with the traditional A-value method, two primary improvements are introducing the time coefficient and vertical multi-box assumption into the original box model. The algorithm can accurately calculate the PM2.5 AEC under different circulation patterns and predict the short-time dynamic change of AEC. The results show that the time coefficient effectively reduced the estimation errors when the initial PM2.5 concentration, horizontal wind speed and PBL heights change greatly with time, such situation is consistent with most circulation patterns. And the improvement of multi-box model is much more remarkable when the PM2.5 concentration and horizontal wind change greatly in the vertical direction, such as A, NE and W type circulations. The ideal AEC under polluted circulation patterns won't increase infinitely with wind speed and PBL height, generally less than 30 t/h. The horizontal advection has a much greater effect on expanding the capacity of PM2.5 than the vertical diffusion under clean circulation patterns, and the maximum value of ideal AEC can reach 50 t/h. The positive residual AEC under clean circulations indicates surplus capacity for PM2.5 because of vigorous turbulences, while weak diffusion and ventilation conditions under polluted circulations lead to negative residual AEC and insufficient capacity of atmosphere.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Algoritmos , China , Monitoramento Ambiental , Material Particulado/análise , Estações do Ano
12.
J Colloid Interface Sci ; 606(Pt 1): 135-147, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34388566

RESUMO

As a pseudocapacitive electrode material, nickel-cobalt bimetallic phosphide has attracted wide attention with its advantage in capacitance and chemical activity. While, like Ni-Co oxides or sulfides, the application of nickel-cobalt bimetallic phosphide is generally hampered by its confined conductivity, low chemical stability and unsatisfactory cycle durability. Herein, this work demonstrates a NiCoP@CNT@PPy (NCP@CNT@PPy) composite that is obtained by polymerizing pyrrole monomer on the surface of NiCoP@CNT complex. According to density functional theory (DFT), it is theoretically demonstrated that the bimetallic Ni-Co phosphide (NiCoP) can exhibit more electrons near the Fermi level than single Ni or Co phosphide. Under the combined effects of carboxylic carbon nanotubes (c-CNTs) and polypyrrole (PPy), the NCP@CNT@PPy electrode exhibits excellent electrochemical performance. In addition, a flexible asymmetric supercapacitor (ASC) is prepared, which demonstrated high energy density and admirable heat-resistance and flexibility performance, showing huge potential in the application of heat-resistant storage energy systems and portable wearable devices.


Assuntos
Nanotubos de Carbono , Dispositivos Eletrônicos Vestíveis , Eletrodos , Polímeros , Pirróis
13.
Sci Total Environ ; 810: 152276, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34902419

RESUMO

To quantify the emission characteristics of large ocean-going ships, onboard measurements were carried out for a large ocean-going vessel using portable emission measurement system (PEMS). The emission factors (EFs) of conventional pollutants and volatile organic compounds (VOCs) were greatly influenced by real-world operating conditions and engine loads. The sulfur dioxide (SO2) and particulate matter (PM) emissions were mainly influenced by fuel type. The particle size distribution basically showed a single peak pattern, with nucleation mode particles as the main particles and the peak particle sizes ranging between 30 nm and 50 nm. The EFs for particle number (PN) ranged from 2.82 × 1016 to 4.49 × 1016 #/kwh. Carbonaceous components accounted for approximately 31.8% to 41.6% of the PM. SO42-, NH4+, Ca2+, Na+, and NO3- were dominant in water-soluble ions, while V and Ni were high-concentration metal elements, with the ratio of V: Ni ranging from 0.17 to 0.33. Increase in driving speed can lead to the increase in VOCs emissions. Our study presented a comprehensive test method with PEMS, which provides a reference for acquiring future real-world EFs. However, only one representative ship in China using a specific fuel was selected for the test, so it is important to characterize a broader range of ships and fuels.


Assuntos
Poluentes Atmosféricos , Emissões de Veículos , Poluentes Atmosféricos/análise , Oceanos e Mares , Tamanho da Partícula , Material Particulado/análise , Navios , Emissões de Veículos/análise
15.
Aging Dis ; 12(8): 1977-2002, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34881081

RESUMO

Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization.

16.
J Healthc Eng ; 2021: 4022312, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34868516

RESUMO

This research was to explore the accuracy of ultrasonic diagnosis based on artificial intelligence algorithm in the diagnosis of pregnancy complicated with brain tumors. In this study, 18 patients with pregnancy complicated with brain tumor confirmed by pathology were selected as the research object. Ultrasound contrast based on artificial bee colony algorithm was performed and diagnosed by experienced clinicians. Ultrasonic image will be reconstructed by artificial bee colony algorithm to improve its image display ability. The pathological diagnosis will be handed over to the physiological pathology laboratory of the hospital for diagnosis. The doctor's ultrasonic diagnosis results were compared with the pathological diagnosis stage results of patients, and the results were analyzed by statistical analysis to evaluate its diagnostic value. The comparison results showed that the number and classification of benign tumors were the same, while in malignant tumors, the number diagnosis was the same, but there was one patient with diagnostic error in classification. One case of mixed glial neuron tumor was diagnosed as glial neuron tumor, and the diagnostic accuracy was 94.44% and the K value was 0.988. The diagnostic results of the two were in excellent agreement. The results show that, in the ultrasonic image diagnosis of patients with brain tumors during pregnancy based on artificial intelligence algorithm, most of them are benign and have obvious symptoms. Ultrasound has a good diagnostic accuracy and can be popularized in clinical diagnosis. The results can provide experimental data for the clinical application of ultrasonic image feature analysis based on artificial intelligence as the diagnosis of pregnancy complicated with brain tumors.

17.
Front Oncol ; 11: 702887, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34858803

RESUMO

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

18.
Medicine (Baltimore) ; 100(49): e28163, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34889286

RESUMO

OBJECTIVE: Chronic prostatitis (CP) is a common disease in the outpatient department of males and urology. Clinical studies have found that acupuncture combined with traditional Chinese medicine (TCM) has achieved good results in treating CP, but its efficacy and safety are not completely clear. This study aimed to investigate the efficacy and safety of acupuncture combined with TCM in the treatment of CP. METHODS: Randomized controlled trials of acupuncture combined with TCM in treating CP were screened by searching PubMed, Embase, Cochrane Library, CNKI, etc. The retrieval time was from the database establishment date to March 31, 2021. The Cochrane Collaborative Risk Bias Assessment tool was used to evaluate literature's methodological quality of the literature. The RevMan5.4 software was used for the meta-analysis of outcome indicators. The TSA v0.9 software was used for sequential trial analysis (TSA) of effectiveness. RESULTS: In this study, 19 related randomized controlled trial studies were included, with a total of 1831 cases. The results of the meta-analysis showed that acupuncture combined with TCM could significantly improve the clinical efficacy of CP (OR = 3.76, 95%CI: 2.82 to 5.02, P < .00001), reduce the total score of The National Institutes of Health chronic prostatitis symptom index (MD = -4.00, 95%CI: -4.67 to 3.33, P < .00001), and improve patients' urination symptoms (MD = -1.10, 95%CI: -1.23 to -0.97, P < .00001), alleviated the pain symptoms of patients (MD = -2.38, 95%CI: -2.41 to -2.35, P < .00001), improved the quality of life of patients (MD = -1.69, 95%CI: -1.97 to -1.41, P < .00001), decreased the scores of TCM symptoms of patients (MD = -2.39, 95%CI: -3.45 to -1.33, P < .00001), and did not increase the adverse reactions of patients (MD = 1.09, 95%CI: 0.57 to 2.06, P = .8). The results of publication bias showed that this study was not affected by publication bias, and the conclusion was reliable. TSA showed that acupuncture combined with TCM was effective in treating CP. CONCLUSION: Acupuncture combined with TCM is safe and effective for alleviating CP. It can be used as an effective treatment for chronic prostatitis in the clinic.Registration number: DOI 10.17605/OSF.IO/Z8FJM.

20.
Chin J Integr Med ; 2021 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-34874517

RESUMO

OBJECTIVE: To explore the effect of Shenmai Injection (, SMI) on the long-term prognosis of patients with chronic heart failure (CHF). METHODS: The Hospital Information System was used to extract data of CHF patients, and the retrospective cohort study was conducted for analysis. In non-exposed group, standardized Western medicine treatment and Chinese patent medicine or decoction were applied without combination of SMI while in the exposed group, SMI were applied for more than 7 days. Evaluation indicators are followed with New York Heart Association functional classification (NYHA classification), left ventricular ejection fraction (LVEF), N-terminal brain natriuretic peptide precursor (NT-ProBNP), cardiogenic death and heart failure (HF) readmission. Statistical analysis includes Kaplan-Meier analysis and Cox regression which are used to explore the relationship between SMI and outcome events. RESULTS: A total of 1,211 eligible CHF patients were involved and finally 1,047 patients were followed up successfully. After treatment, the cases of NYHA classification decline in the exposed and non-exposed groups accounted for 64.30% and 43.45%, respectively; the improvement values of LVEF were 8.89% and 7.91%, respectively; the improvement values of NT-ProBNP were 909 pg/mL and 735 pg/mL, respectively. After exposure on SMI, the rates of cardiogenic death and HF readmission reduced from 15.43% to 10.18% and 38.93% to 32.37%. According to Kaplan-Meier analysis, the log-rank P value of SMI and cardiogenic death was 0.014, while the counterpart of SMI and HF readmission was 0.025. Cox regression analysis indicated that for cardiogenic death, age, cardiomyopathy, diabetes, and NYHA classification were risk factors while ß-blockers, aldosterone receptor antagonists, Chinese patent medicine/decoction and SMI were protective factors. Likewise, for HF readmission, age, cardiomyopathy, and NYHA classification were risk factors while SMI was a protective factor. CONCLUSION: Combination with SMI on the standardized Western medicine treatment can effectively reduce cardiogenic mortality and readmission rate in CHF patients, and thereby improve the long-term prognosis.

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