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1.
Spectrochim Acta A Mol Biomol Spectrosc ; 224: 117420, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31369991

RESUMO

The simultaneous measurements of multiple parameters (film thickness, temperature, etc.) of the liquid films are crucial for the design and optimization of relevant industrial processes. Here, a sensor based on diode-laser absorption spectroscopy (DLAS) was developed to simultaneously measure liquid water film thicknesses and temperatures by combining two diode lasers at different wavenumber positions, 6718.2 cm-1 and 7040.8 cm-1. Serious beam steering effects can be avoided by adding an integrating sphere to improve the performance of the sensor for the investigations of dynamic films. The measurement accuracies of this sensor were firstly validated by a calibration tool with known film thicknesses and temperatures. It revealed that the averaged deviations between the measured film thicknesses/temperatures and the corresponding known parameters were 4.58% and 1.34%, respectively. The sensor was then employed to study liquid film evaporation processes on a horizontal quartz glass plate. The imaging method and the thermocouple were simultaneously employed to obtain the film thicknesses and temperatures to compare with the DLAS results. It showed that the average evaporation rates of the liquid films were 0.34/0.41/0.57 µm/s at different temperatures (340/360/390 K) of the heat gun outlet, respectively, and the evaporation rates increased with the increasing film temperatures. The whole evaporation process can be tracked with the sensor. Furthermore, the sensor was applied to simultaneously determine the variations of liquid film thicknesses and temperatures in a flow channel. It was found that the film temperatures remained almost constant during passage of low-amplitude surface waves at the film temperatures 308/315/323 K.

2.
Burns ; 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31672469

RESUMO

OBJECTIVE: To investigate the effects of music and/or tramadol on pain and anxiety in burn outpatients undergoing dressing changes. DESIGN: Randomized controlled trial. SETTING: Burns and Plastic Reconstruction Unit. PARTICIPANTS: Patients (N=180) with burns on up to 10%-30% of the total body surface area (TBSA). INTERVENTIONS: The patients were randomly allocated to 4 equal-sized groups as follows: (1) tramadol group (TG), patients received 100mg of tramadol orally 20min before the dressing change; (2) music group (MG), patients listened to self-selected music during the dressing change; (3) music-plus-tramadol group (MTG), patients received tramadol and listened to self-selected music; and (4) control group (CG), patients received a routine dressing change only. All patients underwent the interventions once per day for 2days. MAIN OUTCOME MEASURES: McGill Pain Questionnaire Short Form (MPQ-SF) (primary outcome), McGill Pain Persian version of Burn Specific Pain Anxiety Scale (BSPAS) (primary outcome), and heart rate (HR) and overall patient satisfaction (secondary outcomes). RESULTS: The results showed that music-plus-tramadol group (MTG) had better outcomes with respect to pain and anxiety management during dressing changes. CONCLUSIONS: In comparison with music or tramadol alone, the integration of music and tramadol offers a secure and favorable treatment choice to relieve pain and anxiety, ultimately improving the satisfaction levels of burn outpatients during dressing changes.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31756898

RESUMO

Airborne fine particulate matter (PM2.5) is an important factor affecting indoor air quality and is significantly related to human health. A lot of research has been done on PM2.5 pollution control in buildings, but there is lack of systematic indoor PM2.5 pollution control for engineering applications. In this study, first, we propose an outdoor calculated concentration of PM2.5 in 74 cities, in China, using the "not guaranteed for five days" method, which is based on outdoor PM2.5 concentration monitoring data from 2016 to 2018. Then, different levels of indoor calculated concentrations of PM2.5 (25 µg/m3, 35 µg/m3, and 75 µg/m3) are put forward. Secondly, methods for selecting air purification equipment in centralized, semi-centralized, and decentralized air conditioning systems are proposed. Finally, PM2.5 pollution control measures and system energy-saving operation strategies in buildings are put forward. This study stipulates the calculation of PM2.5 concentration, unifies design methods, proposes control measures, and standardizes operations management. The aim of this study is to provide technical guidance for engineering design, construction and operation, and therefore to reduce the risk of indoor diseases caused by exposure to PM2.5.

4.
J Med Chem ; 2019 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-31738550

RESUMO

Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines were designed, synthesized and assayed, leading to the discovery of a benzylamine derivative (compound 4, SLL-039) as a highly selective and potent κ opioid agonist (κ, Ki=0.47 nM, κ/µ=682, κ/δ=283), which was confirmed by functional assays in vitro and antinociceptive assays in vivo. The in vivo effect could be blocked by pretreatment with the selective κ antagonist nor-BNI. Moreover, this compound did not induce sedation, a common dose limiting effect of κ opioid receptor agonists, at its analgesic dose compared to U50,488H. The dissociation of sedation/antinociception found in SLL-039 was assumed to be correlated with the occupation of its benzamide motif in a unique subsite involving V1182.63, W124EL1 and E209EL2.

5.
Ecotoxicol Environ Saf ; : 109946, 2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31759742

RESUMO

The soils near the abandoned Shimen Realgar Mine are characterized by containing extremely high contents of total and soluble arsenic. To determine the microbial reactions and environmental factors affecting the mobilization and release of arsenic from soils phase into pore water, we collected 24 soil samples from the representative points around the abandoned Shimen Realgar Mine. They contained 8310.84 mg/kg total arsenic and 703.21 mg/kg soluble arsenic in average. The soluble arsenic in the soils shows significant positive and negative correlations with environmental SO42-/TOC/pH/PO43-, and Fe/Mn, respectively. We found that diverse dissimilatory As(V)-respiring prokaryotes (DARPs) and As(III)-oxidizing bacteria (AOB) exist in all the examined soil samples. The activities of DARPs led to 65-1275% increase of soluble As(III) in the examined soils after 21.0 days of anaerobic incubation, and the microbial dissolution and releases of arsenic show significant positive and negative correlations with the environmental pH/TN and NH4+/PO43-, respectively. In comparison, the activities of AOB led to 24-346% inhibition of the dissolved oxygen-mediated dissolution of arsenic in the soils, and the AOB-mediated releases of As(V) show significant positive and negative correlations with the environmental SO42- and pH/NH4+, respectively. The microbial communities of 24 samples contain 54 phyla of bacteria that show extremely high diversities. Total arsenic, TOC, NO3- and pH are the key environmental factors that indirectly controlled the mobilization and release of arsenic via influencing the structures of the microbial communities in the soils. This work gained new insights into the mechanism for how microbial communities catalyze the dissolution and releases of arsenic from the soils with extremely high contents of arsenic.

6.
Chem Rev ; 119(22): 11761-11817, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31729868

RESUMO

This article aims to review nature-inspired chemical sensors for enabling fast, relatively inexpensive, and minimally (or non-) invasive diagnostics and follow-up of the health conditions. It can be achieved via monitoring of biomarkers and volatile biomarkers, that are excreted from one or combination of body fluids (breath, sweat, saliva, urine, seminal fluid, nipple aspirate fluid, tears, stool, blood, interstitial fluid, and cerebrospinal fluid). The first part of the review gives an updated compilation of the biomarkers linked with specific sickness and/or sampling origin. The other part of the review provides a didactic examination of the concepts and approaches related to the emerging chemistries, sensing materials, and transduction techniques used for biomarker-based medical evaluations. The strengths and pitfalls of each approach are discussed and criticized. Future perspective with relation to the information and communication era is presented and discussed.

7.
Int J Mol Sci ; 20(21)2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31652783

RESUMO

Phosphorus is one of the mineral nutrient elements essential for plant growth and development. Low phosphate (Pi) availability in soils adversely affects crop production. To cope with low P stress, remodeling of root morphology and architecture is generally observed in plants, which must be accompanied by root cell wall modifications. It has been documented that cell wall proteins (CWPs) play critical roles in shaping cell walls, transmitting signals, and protecting cells against environmental stresses. However, understanding of the functions of CWPs involved in plant adaptation to P deficiency remains fragmentary. The aim of this review was to summarize advances in identification and functional characterization of CWPs in responses to P deficiency, and to highlight the critical roles of CWPs in mediating root growth, P reutilization, and mobilization in plants.

8.
ACS Sens ; 4(10): 2588-2592, 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31613098

RESUMO

This letter reports on a novel cost-efficient and multifunctional barcode-like sensors array (BLSA) printed with a conductive bioinspired smart ink. The conductive  ink (P@G ink), which can be further chemically engineered with different organic ligands, was generated via facile one-pot hydrothermal reduction of graphene oxide (GO) in dopamine (DA) as coreductan Usingvarious  chemical derivatives of the P@G inks on a flexible substrate (e.g., Kapton), a highly integrated BLSA as well as smart nose/tongue mimic array were generated for simultaneous sensing and distinguishing of complex physical and chemical stimuli, including temperature, light, air pressure, relative humidity, and volatile organic compounds (VOCs). Due to these very attractive features, the reported P@G ink-based BLSA would have the potential for unique opportunities regarding "all-in-one"-yet cost-effective-disposable electronics and sensors.

9.
BMC Complement Altern Med ; 19(1): 282, 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31653216

RESUMO

BACKGROUND: Aim of this study was to evaluate the effectiveness of scalp, tongue, and Jin's 3-needle acupuncture for the improvement of postapoplectic aphasia. METHOD: PubMed, Cochrane, Embase databases were searched using index words to identify qualifying randomized controlled trials (RCTs). Meta-analyses of odds ratios (OR) or standardized mean differences (SMD) were performed to evaluate the outcomes between investigational (scalp / tongue / Jin's 3-needle acupuncture) and control (traditional acupuncture; TA and/or rehabilitation training; RT) groups. RESULTS: Thirty-two RCTs (1310 participants in investigational group and 1270 in control group) were included. Compared to TA, (OR 3.05 [95% CI: 1.77, 5.28]; p<0.00001), tongue acupuncture (OR 3.49 [1.99, 6.11]; p<0.00001), and Jin's 3-needle therapy (OR 2.47 [1.10, 5.53]; p = 0.03) had significantly better total effective rate. Compared to RT, scalp acupuncture (OR 4.24 [95% CI: 1.68, 10.74]; p = 0.002) and scalp acupuncture with tongue acupuncture (OR 7.36 [3.33, 16.23]; p<0.00001) had significantly better total effective rate. In comparison with TA/RT, scalp acupuncture, tongue acupuncture, scalp acupuncture with tongue acupuncture, and Jin's three-needling significantly improved ABC, oral expression, comprehension, writing and reading scores. CONCLUSION: As treatments to postapoplectic aphasia, scalp / tongue acupuncture and Jin's Three-needling are found better than TA and/or RT in yielding total effective rate and improving ABC, oral expression, comprehension, reading and writing scores.

10.
Mol Cancer Res ; 2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31662449

RESUMO

Pancreatic cancer (PC) is a highly lethal malignancy with poor prognosis due to the lack of early symptoms and resultant late diagnosis. Thus, it is extremely urgent to establish a simple and effective method for the early diagnosis of PC. Although some studies have provided positive evidence for the use of exosomal surface protein glypican-1 (GPC1) as a biomarker for early screening, its clinical application is still controversial. Here, we systematically verified the role of exosomal GPC1 as a potential screening biomarker. First, bottleneck problems of a stable detection method and an identification standard were systematically studied, and a Python based standardized data processing method was established to analyse exosomal GPC1 expression. Second, a detection panel consisting of exosomal GPC1, exosomal CD82 (Cluster of Differentiation 82), and serum carbohydrate antigen 19-9 (CA19-9) was employed for PC detection. This panel exhibited excellent diagnostic results (area under the curve (AUC): 0.942) and could effectively distinguish healthy people from PC patients (P-value threshold: 0.2282) and pancreatitis patients from PC patients (P-value threshold: 0.5467). Implications: These results indicate that the combined detection of exosomal GPC1, exosomal CD82 and serum CA19-9 shows great promise as a standard method for PC detection and that this panel could be further applied for screening PC in Chinese populations.

11.
Chemosphere ; 237: 124412, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31376695

RESUMO

BACKGROUND: The association between multiple metal concentrations and gestational diabetes mellitus (GDM) is poorly understood. METHODS: A total of 776 women with GDM and an equal number of controls were included in the study. Concentrations of metals in participants' blood (nickel (Ni), arsenic (As), cadmium (Cd), antimony (Sb), thallium (Tl), mercury (Hg), lead (Pb)) were measured using inductively coupled plasma-mass. We used unconditional logistical regression models to estimate the associations between metals and GDM. We also employed weighted quantile sum (WQS) regression and principal components analysis (PCA) to examine metal mixtures in relation to GDM. RESULTS: An increased risk of GDM was associated with As (OR = 1.49, 95% CI: 1.11, 2.01 for the 2nd tertile vs. the 1st tertile) and Hg (OR = 1.43, 95% CI: 1.09, 1.88 for the 3rd tertile vs. the 1st tertile). In WQS analysis, the WQS index was significantly associated with GDM (OR = 1.20, 95% CI: 1.02, 1.41). The major contributor to the metal mixture index was Hg (69.2%), followed by Pb (12.8%), and As (11.3%). Based on PCA, the second principal component, which was characterized by Hg, Ni, and Pb, was associated with an increased risk of GDM (OR = 1.46, 95% CI: 1.02, 2.08 for the highest quartile vs. the lowest quartile). CONCLUSIONS: Our study results suggest that high metal levels are associated with an increased risk of GDM, and this increased risk is mainly driven by Hg and, to a lesser extent, by Ni, Pb, and As.

12.
MAbs ; 11(8): 1443-1451, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31402780

RESUMO

Blockade of immune checkpoint pathways by programmed cell death protein 1 (PD-1) antibodies has demonstrated broad clinical efficacy against a variety of malignancies. Sintilimab, a highly selective, fully human monoclonal antibody (mAb), blocks the interaction of PD-1 and its ligands and has demonstrated clinical benefit in various clinical studies. Here, we evaluated the affinity of sintilimab to human PD-1 by surface plasmon resonance and mesoscale discovery and evaluated PD-1 receptor occupancy and anti-tumor efficacy of sintilimab in a humanized NOD/Shi-scid-IL2rgamma (null) (NOG) mouse model. We also assessed the receptor occupancy and immunogenicity of sintilimab from clinical studies in humans (9 patients with advanced solid tumor and 381 patients from 4 clinical studies, respectively). Sintilimab bound to human PD-1 with greater affinity than nivolumab (Opdivo®, MDX-1106) and pembrolizumab (Keytruda®, MK-3475). The high affinity of sintilimab is explained by its distinct structural binding mode to PD-1. The pharmacokinetic behavior of sintilimab did not show any significant differences compared to the other two anti-PD-1 mAbs. In the humanized NOG mouse model, sintilimab showed superior PD-1 occupancy on circulating T cells and a stronger anti-tumor effect against NCI-H292 tumors. The strong anti-tumor response correlated with increased interferon-γ-secreting, tumor-specific CD8+ T cells, but not with CD4+ Tregs in tumor tissue. Pharmacodynamics testing indicated a sustained mean occupancy of ≥95% of PD-1 molecules on circulating T cells in patients following sintilimab infusion, regardless of infusion dose. Sintilimab infusion was associated with 0.52% (2/381 patients) of anti-drug antibodies and 0.26% (1/381 patients) neutralizing antibodies. These data validate sintilimab as a novel, safe, and efficacious anti-PD-1 mAb for cancer immunotherapy.

13.
Inorg Chem ; 58(16): 10694-10703, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31390195

RESUMO

The reactions of chiral ligand (R)/(S)-1,1'-binaphthyl-2,2'-diyl phosphate (R-HL/S-HL) and ErCl3·6H2O afford two pairs of di- and tetranuclear enantiomers [Er2(R/S-L)4(EtOH)6]Cl2·6.5EtOH (R-1, S-1) and [Er4(PO4)(R/S-L)8(EtOH)3(H2O)]2Cl(OH)·15EtOH·11H2O (R-2, S-2). The nuclearity of these complexes is controllable and depends on the reaction temperature with a template effect. Their chirality was evidenced by circular dichroism (CD) spectra. R-1 exhibits two magnetic relaxation pathways under a zero field, with an apparent barrier of 40 K. Ab initio calculations revealed a ferromagnetic dipolar interaction between these two Er(III) ions, the equatorial nature of the ligand field, and the probable origin of the two relaxations.

14.
Medicine (Baltimore) ; 98(34): e16898, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31441868

RESUMO

Both spiral plate and Herbert screw fixations have been clinically adopted for treating midshaft displaced clavicle fractures. However, the biomechanical properties of the 2 implant fixations have not yet been thoroughly evaluated. Here we report the results of a finite element analysis of the biomechanical properties of midshaft clavicle fractures treated with Herbert screw and spiral plate fixation. Hebert screw fixation showed stress distribution similar to intact clavicle under all loading conditions, but provided less stability than did spiral plate fixation. Postoperatively, excessive shoulder activities and weight-bearing should be avoided. Spiral plate fixation provides greater stability, but is associated with stress shielding. These results demonstrate that Herbert screw fixation is suitable for the treatment of simple displaced clavicluar fractures, but excessive shoulder activity and weight-bearing should be avoided after the operation. Therefore, spiral plate fixation may be preferred for patients requiring an early return to activity.


Assuntos
Clavícula/lesões , Fixação Interna de Fraturas/métodos , Fraturas Ósseas/cirurgia , Adulto , Fenômenos Biomecânicos , Placas Ósseas , Parafusos Ósseos , Clavícula/anatomia & histologia , Clavícula/diagnóstico por imagem , Feminino , Humanos , Imagem Tridimensional , Modelos Anatômicos , Melhoria de Qualidade , Adulto Jovem
15.
Chemistry ; 25(51): 11940-11944, 2019 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-31317582

RESUMO

In addition to superior enzyme-mimicking abilities, nanozymes also have intrinsic physicochemical properties. Integrating the enzyme-like activities and tunable physicochemical properties into a single nanoparticle is a promising strategy for versatile nanozyme design and application. Herein, a composite nanozyme in which Au nanoparticles are encapsulated by Au nanoclusters (AuNP@AuNCs) is presented. By integrating the peroxidase-mimicking ability of fluorescent Au NCs with the glucose oxidase-like activity of Au NPs, the composite nanozyme realized cascade assay of glucose without the aid of external indicators. Compared to traditional multistep colorimetric methods, the analytical process was highly simplified by using the self-responsive nanozyme. This synthetic strategy provided valuable insights into exploring talented nanozymes for sensing diverse targets.


Assuntos
Glucose Oxidase/química , Glucose/metabolismo , Ouro/química , Nanopartículas Metálicas/química , Peroxidase/química , Colorimetria/métodos , Glucose/química , Glucose Oxidase/metabolismo
16.
Photodiagnosis Photodyn Ther ; 27: 385-387, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31301435

RESUMO

Kerion refers to the severe inflammatory reaction which occurs in some cases of fungal infection of the hair or hair follicles. Successful treatment is a challenge for the small number of kerion patients who show poor efficacy of oral antifungal agents. In recent years, photodynamic therapy (PDT) has been proven to be a useful treatment for a variety of fungal infections. In this case report, a 9-year-old Chinese girl presented with erythema, pustular and tender plaques on her scalp for 2 month. The diagnosis of kerion was made based on clinical features and positive mycological findings. After the disease relapsed with oral administration of itraconazole for 6 weeks, she was successfully cured by three sessions of ALA-PDT combined with itraconazole. This case report suggests that ALA-PDT provides a good alternative and adjutant choice for kerion with safety, less side effects, and good repeatability.

17.
Medicine (Baltimore) ; 98(29): e16523, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31335730

RESUMO

Indentation hardness test is a good in vitro method of bone quality assessment. The purpose of this study is to explore the distribution characteristics of bone tissue microhardness in tibial diaphysis and provide theoretical support for the test site selection of the reference point indentation technique.Three fresh right tibias were obtained from 3 cadaver donors. The tibial diaphysis was evenly divided into 6 sections. Bone specimens with a thickness of 3 mm were cut from each part. After appropriate management, micro-indentation tests were performed in various regions of the specimens to acquire the microhardness values of the tibial diaphysis. Statistical analysis was performed by randomized block design variance analysis to study the distribution characteristics of bone microhardness.72 regions were selected for 360 effective indentations. We found that the bone microhardness is inhomogeneous in tibia diaphysis. Mean hardness value of the anterior, medial, posterior, lateral region of tibia diaphysis was 45.58 ±â€Š4.39 Vickers hardness (HV), 52.33 ±â€Š3.93 HV, 54.00 ±â€Š4.21 HV, 52.89 ±â€Š4.44 HV, respectively. The anterior cortex exhibits lower microhardness value than the other regions (P < .001). Within the same region, microhardness varies significantly with positions in the tibial diaphysis. The variations in indentation hardness are bound to have a significant impact on the comparability of different reference point indentation (RPI) studies.The results of this study indicated the regional microhardness difference in the human tibia diaphysis. The microhardness of different planes in the same region is also inconsistent. Inhomogeneous distribution of indentation microhardness would have considerable influence in the test site selection of RPI technique. The data collected in our study would contribute to the design of highly precise 3D printing implants and bionic bones with gradient elastic modulus.


Assuntos
Testes de Dureza/métodos , Tíbia/anatomia & histologia , Fenômenos Biomecânicos , Cadáver , Osso Cortical/anatomia & histologia , Diáfises/anatomia & histologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
18.
Angew Chem Int Ed Engl ; 58(42): 14915-14919, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31356720

RESUMO

Heterostructured metal-organic framework (MOF)-on-MOF thin films have the potential to cascade the various properties of different MOF layers in a sequence to produce functions that cannot be achieved by single MOF layers. An integration method that relies on van der Waals interactions, and which overcomes the lattice-matching limits of reported methods, has been developed. The method deposits molecular sieving Cu-TCPP (TCPP=5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin) layers onto semiconductive Cu-HHTP (HHTP=2,3,6,7,10,11-hexahydrotriphenylene) layers to obtain highly oriented MOF-on-MOF thin films. For the first time, the properties in different MOF layers were cascaded in sequence to synergistically produce an enhanced device function. Cu-TCPP-on-Cu-HHTP demonstrated excellent selectivity and the highest response to benzene of the reported recoverable chemiresistive sensing materials that are active at room temperature. This method allows integration of MOFs with cascading properties into advanced functional materials.

19.
Medicine (Baltimore) ; 98(27): e16040, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31277097

RESUMO

BACKGROUND: Intraoperative blood salvage as a blood-saving strategy has been widely used in surgery. Considering its theoretic risk of malignant tumor cells being reinfused and the corresponding blood metastases, the safety of intraoperative blood salvage in cancer surgery remains controversial. METHODS: Following the Preferred Reporting Items for Systemic Review and Meta-Analysis (PRISMA), we searched the Cochrane Library, MEDLINE and EMBASE to November 2017. We included only studies comparing intraoperative blood salvage with allogeneic blood transfusion. RESULTS: This meta-analysis included 9 studies with 4354 patients with 1346 patients in the intraoperative blood salvage group and 3008 patients in the allogeneic blood transfusion group. There were no significant differences in the 5-year overall survival outcome (odds ratio [OR] 1.12; 95% confidence interval [CI], 0.80-1.58), 5-year disease-free survival outcome (OR 1.08; 95% CI 0.86-1.35), or 5-year recurrence rate (OR 0.86; 95% CI 0.71-1.05) between the 2 study groups. Subgroup analysis also showed no significant differences in the 5-year overall survival outcome (OR 0.97; 95% CI 0.57-1.67) of hepatocellular carcinoma patients in liver transplantation. CONCLUSIONS: For patients with malignant disease, intraoperative blood salvage did not increase the tumor recurrence rate and had comparable survival outcomes with allogeneic blood transfusion.


Assuntos
Transfusão de Sangue Autóloga/efeitos adversos , Recuperação de Sangue Operatório/efeitos adversos , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Recidiva Local de Neoplasia/etiologia , Neoplasias/cirurgia , Estudos Retrospectivos , Análise de Sobrevida
20.
Int J Biol Macromol ; 138: 207-214, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31306708

RESUMO

In this work, paclitaxel was loaded into porous starch in the form of nanoparticles (PNPS), and the properties of PNPS were investigated by using raw paclitaxel and the system of paclitaxel directly loaded into porous starch (PPS) as control groups. According to the tested results, the drug loading (DL) and encapsulation efficiency (EE) of PNPS were 14.13%±0.27% and 73.92%±0.54%, higher than that of PPS (9.79%±0.31% and 71.17%±0.67%) respectively. Compared with raw paclitaxel and PPS, PNPS exhibited the more prominent dissolution rate and bioavailability, in which the bioavailability of PPS and PNPS were 2.94 and 5.42 times of that of raw paclitaxel respectively. In addition, the IC50 values of raw paclitaxel, PPS and PNPS on Lewis Lung Carcinoma (LLC) cells were 17,703.41±15.76µM, 95.10±5.32µM and 85.68±7.38µM respectively. Furthermore, the residues of acetone in PPS and PNPS were less than the ICH limit for acetone in class III solvents. To summarize, the preparation of PNPS was a potential method to improve the dissolution and bioavailability of paclitaxel.

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