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1.
Zhongguo Zhen Jiu ; 39(11): 1223-8, 2019 Nov 12.
Artigo em Chinês | MEDLINE | ID: mdl-31724361

RESUMO

OBJECTIVE: To carry out the methodological quality evaluation and content analysis of the evidence-based clinical practice guidelines for acupuncture-moxibustion in China, and to provide reference for the development and updating of future guidelines. METHODS: With Appraisal of Guidelines for Research and EvaluationⅡ(AGREEⅡ), 20 evidence-based clinical practice guidelines for acupuncture and moxibustion in China were evaluated from six aspects: scope and purpose, stakeholder involvement, rigour of development, clarity of presentation, applicability and editorial independence. In addition, the contents of 20 guidelines were systematically analyzed, and the characteristics of guidelines were summarized from the aspects of disease selection, operation technology type and safety. RESULTS: The scores of six domains were scope and purpose (91.1%), stakeholder involvement (68.5%), rigour of development (68.6%), clarity of presentation (90.3%), applicability (34.5%) and editorial independence (16.7%). The recommendations of the 20 acupuncture guidelines covered common clinical problems such as diagnosis, treatment and precautions, which were in line with the clinical characteristics of acupuncture and moxibustion in terms of content structure. CONCLUSION: The methodology of the evidence-based clinical practice guidelines for acupuncture and moxibustion in China conformed to the requirements of AGREEⅡ on the quality evaluation, and the overall quality was moderate, but the aspects of applicability and editorial independence were still needed to be improved. The contents of recommendations in 20 guidelines were specific and clear, in line with the characteristics of acupuncture and moxibustion, presenting clinical reference value. In the future, in the process of guideline development, the method of developing acupuncture and moxibustion guidelines should be constantly improved to improve the quality of the guidelines; in the meantime, more attention should be paid to the generalization and clinical applicability evaluation.

2.
Br J Neurosurg ; : 1-4, 2019 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-31544531

RESUMO

Background: We know of five cases of cervical nerve root variants that have been reported, all of which were found during posterior cervical surgery. We reported two cases of cervical nerve root variants. One had two anomalous branches of the C7 root, is the other had a C5, C6 nerve root communication branch. Case description: A 62-year-old female presented with neck and right upper extremity pain, accompanied by hypaesthesia in her right forearm for 4 months. Preoperative X-ray film, magnetic resonance imaging (MRI) and computed tomography (CT) scan demonstrated C6-7 uncovertebral joint hyperplasia and foraminal stenosis. She underwent posterior cervical endoscopic foraminoplasty. The right C7 nerve root was observed to have two anomalous branches originated from a proximal trunk. After the surgery, the symptoms resolved. A 54-year-old female presented with radiating pain and numbness in her right arm and hand for 4 months. Preoperative MRI showed a C5/6 intervertebral disc herniation. She had hypaesthesia in radial side of her right arm and 1st-3rd fingers. Posterior cervical endoscopic foraminalplasty was performed for the patient. After decompression of the bony wall of the posterior nerve root canal, a 2-mm thick communicating nerve was observed emerging from the dura with the C6 nerve root and exiting to the caudal level. After the surgery, the symptoms resolved immediately. Conclusions: Cervical nerve root variant may be more apparent on edoscopic approaches to the cervical foraminae than at open surgery.

3.
Discov Med ; 28(151): 47-68, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31465725

RESUMO

BACKGROUND: Circulating exosomal microRNAs modulate not only cancer cell metabolism but also the immune response, and therefore plasma exosomal microRNAs might have the potential to be the biomarkers for a number of immune disorders. OBJECTIVE: This study was conducted to identify the common mechanisms among psoriatic arthritis (PsA), psoriasis vulgaris (PV), rheumatoid arthritis (RA), and gouty arthritis (GA). The common expressed plasma exosomal microRNAs in these diseases were determined. METHODS: The expression of microRNAs derived from plasma exosome of patients with PsA (n=30), PV (n=15), RA (n=15), GA (n=15), and healthy controls (n=15) was evaluated via sequencing. Function analysis of common expressed microRNAs was conducted by the Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses. Coexpression analysis was conducted to identify novel and significant genes and proteins by using the Search Tool for the Retrieval of Interacting Genes (STRING). A systematic literature review was conducted to uncover the role of the common microRNAs in the pathogenesis of PsA, PV, RA, and GA. RESULTS: A total of 36 common expressed microRNAs were detected in patients with PsA, PV, RA, and GA. The most significantly enriched biological processes, cellular components, and molecular functions were "homophilic cell adhesion via plasma membrane adhesion molecules," "CCR4-NOT complex," and "calcium ion binding," respectively. "Antigen processing and presentation" was the most significantly enriched pathway. A total of 91 validated coexpressed gene pairs were identified and 16 common expressed microRNAs and 85 potential target genes were screened based on Cytoscape. Of 36 common expressed microRNAs, 5 microRNAs, including hsa-miR-151a-3p, hsa-miR-199a-5p, hsa-miR-370-3p, hsa-miR-589-5p, and hsa-miR-769-5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. Systemic review revealed that the roles of these 5 microRNAs are related to immune disorder and bone injury, which matches the conclusion from GO and KEGG analyses. CONCLUSION: (1) Both immune disorder and bone metabolic dysregulation could be the shared mechanism in the development of PsA, PV, RA, and GA. (2) Immune dysfunction is involved in GA. Our study may shed new light on the diagnosis and treatment strategy of these autoimmune diseases and GA, which warrants further studies.

4.
World Neurosurg ; 129: e586-e593, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31158541

RESUMO

BACKGROUND: The purpose of this study was to determine the number of cases needed to achieve the level of competence for percutaneous endoscopic lumbar diskectomy (PELD) via the bi-needle technique using the cumulative summation test for learning curve (LC-CUSUM). METHODS: A retrospective design was used. We included 60 patients who underwent a single-level PELD via the bi-needle technique performed by a single surgeon. The surgeon had 5 years of experience in open surgery including the transforaminal endoscopic spine system and Yeung endoscopic spine system but no experience in the bi-needle technique. Surgery success was defined as an operative time <60 minutes, and the acceptable procedure was completed within 3 times of C-arm fluoroscopies. The LC-CUSUM was used to analyze the data. RESULTS: The average operative time for PELD via the bi-needle technique was 58.3 ± 12.4 minutes. The mean operative time was 65.7 ± 12.1 minutes in the early learning period (30 cases) and 51.0 ± 7.5 minutes in the late learning period (30 cases) (P < 0.05). On the basis of the evaluation indexes of the operative time and radioactive exposure, the LC-CUSUM signaled proficiency for the bi-needle technique at the 50th-54th operation. Seven cases of complications were observed during the whole learning process, with 6 in the early period and 1 in the late period (P < 0.05). CONCLUSIONS: The novel bi-needle technique is safe and effective for PELD with appropriate patients, and the learning curve is acceptable. A substantial learning period (50-54 cases) is needed before a spine surgeon can master the bi-needle technique.

5.
Zhongguo Zhen Jiu ; 39(5): 529-33, 2019 May 12.
Artigo em Chinês | MEDLINE | ID: mdl-31099226

RESUMO

At present, there is still a underrecognition of the standardization work of acupuncture and moxibustion and the confusion of the basic theory. In order to better advance the next step, it is necessary to review the way and clarify the understanding. Based on the definition, principles and methods of standardization, combined with the practice of standardization of acupuncture and moxibustion, this paper analyzes the relationship between standardization and modernization, standardization and individualization diagnosis and treatment, modern standards and traditional classics, as well as standard development and research, it is proposed to base on the development of disciplines, objectively analyze the different needs at home and abroad, as well as scientific research and clinical practice, and clarify the true purpose of standardization of acupuncture and moxibustion. Standard cannot be simply developed on the base of the individual characteristics of acupuncture, and it is not possible to simply develop acupuncture with standardized concepts and methods. It is necessary to return to acupuncture itself and re-examine acupuncture and moxibustion from a standardized perspective, e.g.in-depth analysis and reflection on which characteristics of acupuncture need to be standardized, how to standardize. It is proposed that the scientific research should be organically combined with the development of standards, and drafting should be in compliance with the rules and the quality of the standard should be improved, so as to truly promote the development of the discipline of acupuncture.


Assuntos
Terapia por Acupuntura , Moxibustão , Cognição , Medicina Tradicional Chinesa
6.
Zhongguo Zhen Jiu ; 39(4): 343-8, 2019 Apr 12.
Artigo em Chinês | MEDLINE | ID: mdl-30957442

RESUMO

On the base of the overall summarization of the development situation of acupuncture standardization, four kinds of relationships are proposed, which needs to be harmonized in the current acupuncture standardization, i.e. standardization and individualization, China acupuncture and world acupuncture, quantity and quality, as well as internal motivation and the government overall instruction. Through in-depth analysis of the problems and their causes, the solutions and measures are put forward, e.g. paying attention to the study on relevant knowledge on standardization and standard publicity, increasing the inputs on theoretic study, strategy study, methodological study as well as the applicability of standards, accelerating the construction of talent team, cultivating and attracting first-class professionals to participate in the standardization work, integrating institutions, straightening out relations as well as improving management system and operation mechanism of acupuncture standardization.


Assuntos
Terapia por Acupuntura , Moxibustão , China , Padrões de Referência
7.
BMJ Open ; 9(3): e025944, 2019 03 23.
Artigo em Inglês | MEDLINE | ID: mdl-30904869

RESUMO

INTRODUCTION: Preoperative radiotherapy followed by total mesorectal excision with adjuvant chemotherapy has been recommended as the preferred treatment method for locally advanced rectal cancer (LARC). Similar rates of local control, survival and toxicity were observed in preoperative long-course chemoradiotherapy (LCRT) (45-50.4 Gy in 25-28 fractions) and in short-course radiotherapy (SCRT) with 25 Gy over five fractions. Both regimens lower the local recurrence rates compared with that of surgery followed by postoperative radiotherapy. With the simplicity and lower cost of SCRT, a growing number of patients have been receiving SCRT as preoperative radiotherapy. However, the currently established SCRT (25 Gy over five fractions) followed immediately by surgery resulted in poor downstaging and sphincter preservation rate. The pathological complete response (pCR) rate is also markedly lower with SCRT than with LCRT (0.7%vs16%). Several studies recommended SCRT with delayed surgery for more than 4 weeks with expectation of improved pathological outcomes and fewer postoperative complications. While a number of clinical trials demonstrated a persistently better overall local control with SCRT than with LCRT, overall survival advantage has not been observed. Since survival is mainly depended on distant metastases, efforts should be made towards more effective pathological response and systemic treatment. Given the apparent advantages of SCRT, we aimed to establish a dose escalation of SCRT and sequential modified FOLFOX6 (mFOLFOX6) as preoperative therapy for LARC with objectives of achieving an optimal balance of safety, cost effectiveness and clinical outcome, and to support further investigation of this regimen in a phase II/III setting. METHODS: In this phase I study, three dose levels (6Gy×5F, 7Gy×5F, 8Gy×5F to gross tumour volume, while keeping the rest of irradiated volume at 5Gy×5) of SCRT followed by four cycles of mFOLFOX6 chemotherapy as neoadjuvant therapy will be tested by using the traditional 3+3 design. The pCR rate, R0 resection rate, sphincter preservation rate and treatment related toxicity will be assessed. ETHICS AND DISSEMINATION: The study protocol was approved by the Ethics Committee of Fujian Medical University Union Hospital (No. 2017YF020-02) and all participants provided written informed consent. Results from our study will be disseminated in international peer-reviewed journals. All study procedures were developed in order to assure data protection and confidentiality. TRIAL REGISTRATION NUMBER: NCT03466424; Pre-results.

8.
Mol Biotechnol ; 61(2): 111-121, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30539414

RESUMO

Basigin is a well-known extracellular stimulator of fibroblasts and may confer resistance to apoptosis of fibroblasts in vitro under some pathological status, but its exact function in fibroblasts and the underlying mechanism remain poorly understood. The systematic Basigin gene knockout leads to the perinatal lethality of mice, which limits the delineation of its function in vivo. In this study, we generated a fibroblast-specific Basigin knock-out mouse model and demonstrated the successful deletion of Basigin in fibroblasts. The fibroblast-specific deletion of Basigin did not influence the growth, fertility and the general condition of the mice. No obvious differences were found in the size, morphology, and histological structure of the major organs, including heart, liver, spleen, lung and kidney, between the knockout mice and the control mice. The deletion of Basigin in fibroblasts did not induce apoptosis in the tissues of the major organs. These results provide the first evidence that the fibroblast-specific Basigin knock-out mice could be a useful tool for exploring the function of Basigin in fibroblasts in vivo.


Assuntos
Basigina/genética , Fibroblastos/metabolismo , Camundongos Knockout , Animais , Apoptose , Basigina/deficiência , Basigina/metabolismo , Feminino , Fertilidade , Fibroblastos/citologia , Deleção de Genes , Marcação de Genes , Genótipo , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Knockout/genética , Camundongos Knockout/crescimento & desenvolvimento , Camundongos Knockout/fisiologia , Camundongos Transgênicos
10.
World Neurosurg ; 119: e53-e59, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29981910

RESUMO

OBJECTIVE: The bi-needle technique is a new technique for percutaneous endoscopic lumbar discectomy. This technique combines the advantages of Yeung endoscopic spine system (YESS) and transforaminal endoscopic spine system (TESSYS) techniques. The aim of this study was to evaluate effectiveness of the bi-needle technique for percutaneous endoscopic lumbar discectomy and compare it with the TESSYS technique. METHODS: We reviewed 86 patients with single-level lumbar disc herniation treated by percutaneous endoscopic lumbar discectomy in our hospital from June 2013 to December 2015. Bi-needle technique was used in 49 patients (30 men, 19 women; average age 40.4 ± 5.2 years). TESSYS technique was used in 37 patients (19 men, 18 women; average age 42.8 ± 6.4 years). Clinical results were evaluated and compared between the 2 groups. RESULTS: Symptoms in both groups were significantly improved at the last follow-up (P < 0.01). There was no statistical difference in visual analog scale and lumbar Japanese Orthopaedic Association scores between bi-needle and TESSYS groups at last follow-up (P = 0.69 and P = 0.33, respectively). Operative time was shorter in the bi-needle group (P < 0.01). Recurrence rate and reoperation rate were lower in the bi-needle group (P = 0.04 and P = 0.03, respectively). Discitis was diagnosed in 2 patients in the TESSYS group. There were no patients with postoperative discitis in the bi-needle group. CONCLUSIONS: The bi-needle technique is safe and effective for treatment of lumbar disc herniation. Compared with TESSYS technique, operative time is shorter, and recurrence and reoperation rates are lower.

11.
Huan Jing Ke Xue ; 39(5): 2086-2094, 2018 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965508

RESUMO

Samples collected from 12 rivers with typical vegetation types in the permafrost regions on the Qinghai-Tibetan Plateau were incubated in the laboratory, and the relationships among the vegetation types, river discharges, the compositions of dissolved organic carbon (DOC), permafrost areas, riverine DOC concentration, biodegradability of dissolved organic carbon (BDOC), and the biodegradation kinetics were examined. The results showed that the DOC concentrations of typical vegetation types in the basin, such as alpine meadow (AM), alpine swamp meadow-alpine meadow (ASM-AM), alpine meadow-alpine steppe (AM-AS), and alpine meadow-alpine steppe-bare soil (AM-AS-BL), were (5.17±0.21), (5.02±0.50), (3.55±0.25), and (2.79±0.41) mg ·L-1, respectively. The values for the bioavailability of river DOC of different vegetation types were (23.54±2.62)%, (23.66±3.31)%, (18.17±5.26)%, and (11.72±15.56)%, respectively. Correspondingly, the riverine DOC aromaticity increased along with the vegetation cover, while the biodegradation and degradation rates decreased gradually. During the incubation, the reaction of BDOC was in accordance with the first-order kinetics equation. Furthermore, the BDOC in continuous permafrost regions of the rivers was greater than that in the non-continuous permafrost regions. The BDOC in higher discharges were lower than those with lower discharges. Taken together, the results suggested that the vegetation types were the main controlling factors for the BDOC, and BDOC was also related to the discharge and permafrost.

12.
Ann Transl Med ; 6(8): 153, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29862242

RESUMO

Background: Clinical study has demonstrated that the traditional Chinese medicine Qiliqiangxin (QLQX) has protective effects on heart failure. Phenylephrine (PE) is an important inducing factor for cardiac hypertrophy and our previous studies have showed that QLQX attenuates PE-induced cardiac hypertrophy. Besides, QLQX protects against cardiac remodeling after myocardial infarction via activating PPARγ. However, whether QLQX prevents PE-induced cardiac hypertrophy through PPARγ and its coactivator PGC-1α is still unknown. Methods: The effects of QLQX were investigated based on PE induced cardiac hypertrophy mouse models. Echocardiography and hematoxylin-eosin (HE) staining were used to determine cardiac function and cross-sectional area, respectively. Quantitative real time PCR (qRT-PCR) was used to determine ANP and BNP expressions. Based on primary neonatal rat ventricular cardiomyocytes (NRVMs) treated with PE, the cell size and expressions of ANP and BNP were determined by immunofluorescent staining and qRT-PCR, respectively. In addition, western blot was used to determine PPARγ and PGC-1α expressions. Results: In present study, we confirmed that QLQX could significantly attenuate cardiac hypertrophy in mice treated with PE. Then we showed that PPARγ and PGC-1α were downregulated in PE-induced cardiac hypertrophy, and QLQX could block the decrease of PPARγ and PGC-1α both in vitro and in vivo. Importantly, we found that PPARγ inhibitors or PGC-1α siRNAs eliminated the protective effects of QLQX on PE-induced cardiac hypertrophy. Conclusions: Our study suggested that QLQX prevents from PE-induced cardiac hypertrophy by activating PPARγ and its coactivator PGC-1α.

13.
Chin J Integr Med ; 24(4): 260-264, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29696522

RESUMO

BACKGROUND: With the worldwide use and modern development of acupuncture-moxibustion, there is disagreement on its basic definition. There has been an obstacle for clinical practice, research, and legislation. Considering this challenge, the World Federation of Acupuncture-Moxibustion Societies proposes to develop the definition and basic scope of acupuncture-moxibustion with a Delphi study. METHODS: A reactive Delphi method will be used to ask a group of experts to rate the relevance and clarity of a predesigned initial item list. This list was generated by the steering committee through a literature review and group discussion. Forty experts will be selected from many disciplines and continents to ensure appropriate representation. Predefined rules will be applied to modify the items until a consensus is achieved. After achieving the consensus on all items through the survey round, the steering committee will form the definition and basic scope of acupuncture-moxibustion by organizing a literal statement with a detailed explanation.


Assuntos
Terapia por Acupuntura , Técnica Delfos , Moxibustão , Terapia por Acupuntura/ética , Tomada de Decisões , Humanos , Moxibustão/ética , Inquéritos e Questionários
14.
Blood ; 131(10): 1111-1121, 2018 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-29352039

RESUMO

Effective vaccines against malaria caused by Plasmodium falciparum are still lacking, and the molecular mechanism of the host-parasite interaction is not fully understood. Here we demonstrate that the interaction of RAP2, a parasite-secreted rhoptry protein that functions in the parasitophorous vacuole formation stage of the invasion, and CD147 on the host erythrocyte is essential for erythrocyte invasion by P falciparum and is independent from all previously identified interactions involved. Importantly, the blockade of the CD147-RAP2 interaction by HP6H8, a humanized CD147 antibody, completely abolished the parasite invasion with both cure and preventative functions in a humanized mouse model. Together with its long half-life on human red blood cells and its safety profile in cynomolgus monkeys, HP6H8 is the first antibody that offers an advantageous approach by targeting a more conserved late-stage parasite ligand for preventing as well as treating severe malaria.

15.
Oncotarget ; 8(35): 58072-58085, 2017 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-28938538

RESUMO

Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 also induces the expression of proangiogenic factors, such as vascular endothelial growth factor (VEGF-A), in endothelial cells. Unfortunately, angiogenesis positively correlates with cancer development. In this study, we identified RUNX2 as a regulator of ginsenoside Rg1-induced angiogenesis for the first time. We found that RUNX2 was directly targeted and regulated by miR-23a. Additionally, miR-23a was shown to inhibit angiogenesis in both human umbilical vein endothelial cells (HUVECs) and in zebrafish. Furthermore, a decrease in RUNX2 expression resulted in translational repression of VEGF-A in HUVECs. Taken together, this study identified a MiR-23a/RUNX2/VEGF-A pathway in angiogenesis and shed light on the molecular mechanism of Rg1-induced angiogenesis. Thus, RUNX2 might be a potential therapeutic target in Rg1-mediated angiogenesis in cancer.

16.
Huan Jing Ke Xue ; 38(5): 1775-1782, 2017 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965080

RESUMO

Honeycomb briquet,biomass briquettes and bituminous coal from suburb of Beijing were chosen as testing samples to carry out combustion experiments. The characteristics of inorganic pollutant emission factors and VOCs emission factors released from the flue gas were studied. The results showed that under the condition of sufficient combustion, the average emission factors of SO2 from these three types of coal respectively were 1.50,1.91,1.62 kg·t-1;NOx 0.420,0.901,2.20 kg·t-1;CO 22.4,37.3,87.3 kg·t-1. Combustion emission factors of gaseous pollutants for NOx and CO were in the order of bituminous coal > biomass briquettes > honeycomb briquet. SO2 emission factors were in the order of biomass briquettes > bituminous coal > honeycomb briquet. The 2014 emissions inventory of the three civil coal combustion pollutants in Beijing was obtained. Bituminous coal emissions of SO2 was more than 5.5×103 tons,NOx was more than 7.5×103 tons,CO was more than 290×103 tons. All these coal types released more kinds and higher concentrations of volatile organic compounds in ignition phase and damp down stage. VOCs emission factor was the highest during ignition phase, followed by damp down phase.

17.
Korean J Radiol ; 17(6): 846-852, 2016 Nov-Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27833400

RESUMO

OBJECTIVE: To determine whether the appearance of a spiculated mass on a mammogram is associated with luminal A subtype breast cancer and the factors that may influence the presence or absence of the spiculated mass. MATERIALS AND METHODS: Three hundred seventeen (317) patients who underwent image-guided or surgical biopsy between December 2014 and April 2015 were included in the study. Radiologists conducted retrospective assessments of the presence of spiculated masses according to the criteria of Breast Imaging Reporting and Data System. We used combinations of estrogen receptor (ER), progesterone receptor (PR), human epithelial growth factor receptor 2 (HER2), and Ki67 as surrogate markers to identify molecular subtypes of breast cancer. Pearson chi-square test was employed to measure statistical significance of correlations. Furthermore, we built a bi-variate logistic regression model to quantify the relative contribution of the factors that may influence the presence or absence of the spiculated mass. RESULTS: Seventy-one percent (71%) of the spiculated masses were classified as luminal A. Masses classified as luminal A were 10.3 times more likely to be presented as spiculated mass on a mammogram than all other subtypes. Patients with low Ki67 index (< 14%) and HER2 negative were most likely to present with a spiculated mass on their mammograms (p <0.001) than others. The hormone receptor status (ER and PR), pathology grade, overall breast composition, were all associated with the presence of a spiculated mass, but with less weight in contribution than Ki67 and HER2. CONCLUSION: We observed an association between the luminal A subtype of invasive breast cancer and the presence of a spiculated mass on a mammogram. It is hypothesized that lower Ki67 index and HER2 negativity may be the most significant factors in the presence of a spiculated mass.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Mamografia , Adulto , Idoso , Neoplasias da Mama/classificação , Neoplasias da Mama/patologia , Feminino , Humanos , Antígeno Ki-67/metabolismo , Modelos Logísticos , Pessoa de Meia-Idade , Gradação de Tumores , Receptor ErbB-2/metabolismo , Receptores Estrogênicos/metabolismo , Receptores de Progesterona/metabolismo , Estudos Retrospectivos
18.
Huan Jing Ke Xue ; 37(5): 1653-61, 2016 May 15.
Artigo em Chinês | MEDLINE | ID: mdl-27506016

RESUMO

A self-built monitoring sampling system on particulate matters and water soluble ions emitted from stationary combustion sources and a size separated sampling system on particulate matters based on FPS4000 and ELPI + were applied to test particulate matters in fumes of typical stationary combustion sources in Beijing. The results showed that the maximum concentration of total particulate matters in fumes of stationary combustion sources in Beijing was 83.68 mg · m⁻³ in standard smoke oxygen content and the minimum was 0.12 mg · m⁻³. And particle number concentration was in the 104-106 cm⁻³ number of grade. Both mass and number concentration ranking order of particulate matters emitted from stationary combustion sources in Beijing was: heating gas fired boilers < power plant coal fired boilers < heating coal fired boilers. And two or three peaks existed under 1 µm of particulate size for both number size distribution and mass size distribution. The number concentration for PM2.5 accounted for over 99.8% of that for PM10 and that for PM0.1 accounted for over 83% of that for PM2.5. But the proportions of PM0.1, and PM2.5 in PM10 were significantly lower in quality analysis,the proportion of PM2.5 in PM10 was about 82%, and that of PM0.1 in PM2.5 was about 27%-33%.


Assuntos
Poluentes Atmosféricos/análise , Monitoramento Ambiental , Material Particulado/análise , Pequim , Carvão Mineral , Gases/análise , Íons , Centrais Elétricas
19.
Huan Jing Ke Xue ; 37(3): 925-34, 2016 Mar 15.
Artigo em Chinês | MEDLINE | ID: mdl-27337883

RESUMO

This study investigated the horizontal distribution characteristics of nutrients and heavy metals (Zn, As, Cr, Cu, Ni, Pb, Cd and Hg) in January, 2014, and assessed the potential ecological risk of Lake Gehu. It was found that the average contents of TN and TP were 2,207.94 and 708.62 mg · kg⁻¹ respectively. TN and TP contents of the sediments at the centre were significantly highei than those in the north, while the TN content in the south was also significantly higher than that in the north of Lake Gehu. The average contents of Zn, As, Cr, Cu, Ni, Pb, Cd, Hg were 766.59, 350.66, 307.98, 59.54, 122.67, 168.97, 2.34, 0.41 mg · kg⁻¹, respectively. The content of Cu at the centre was significantly higher than that in the north, and the Zn content at the centre was significantly greater than that in the south of Lake Gehu, however the difference in the content of other heavy metals at these three areas was not significant. Furthermore, the obvious correlation between elements and granularity was only found in the aspect of TP, Cu and Hg. The comprehensive pollution index (PI) indicated that the Lake Gehu was heavily polluted, especially the centre and south areas. The potential ecological risk index (RI) showed that Cd, As and Hg had caused serious pollution in Lake Gehu while the other heavy metals only induced slight or medium pollution. According to the contribution of Cd, As and Hg to RI, it was concluded that the sediments in Lake Gehu were at a serious potential ecological risk.


Assuntos
Sedimentos Geológicos/química , Lagos/química , Metais Pesados/análise , Poluentes Químicos da Água/análise , China , Monitoramento Ambiental , Nitrogênio/análise , Fósforo/análise , Medição de Risco
20.
Guang Pu Xue Yu Guang Pu Fen Xi ; 36(2): 471-7, 2016 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-27209752

RESUMO

Recently considerable researches have focused on monitoring vegetation changes because of its important role in regula- ting the terrestrial carbon cycle and the climate system. There were the largest areas with high-altitudes in the Qinghai-Tibet Plateau (QTP), which is often referred to as the third pole of the world. And vegetation in this region is significantly sensitive to the global warming. Meanwhile NDVI dataset was one of the most useful tools to monitor the vegetation activity with high spatial and temporal resolution, which is a normalized transform of the near-infrared radiation (NIR) to red reflectance ratio. Therefore, an extended GIMMS NDVI dataset from 1982-2006 to 1982-2014 was presented using a unary linear regression by MODIS dataset from 2000 to 2014 in QTP. Compared with previous researches, the accuracy of the extended NDVI dataset was improved again with consideration the residuals derived from scale transformation. So the model of extend NDVI dataset could be a new method to integrate different NDVI products. With the extended NDVI dataset, we found that in growing season there was a statistically significant increase (0.000 4 yr⁻¹, r² = 0.585 9, p < 0.001) in QTP from 1982 to 2014. During the study pe- riod, the trends of NDVI were significantly increased in spring (0.000 5 yr⁻¹, r² = 0.295 4, p = 0.001), summer (0.000 3 yr⁻¹, r² = 0.105 3, p = 0.065) and autumn respectively (0.000 6 yr⁻¹, r² = 0.436 7, p < 0.001). Due to the increased vegeta- tion activity in Qinghai-Tibet Plateau from 1982 to 2014, the magnitude of carbon sink was accumulated in this region also at this same period. Then the data of temperature and precipitation was used to explore the reason of vegetation changed. Although the trends of them are both increased, the correlation between NDVI and temperature is higher than precipitation in vegetation grow- ing season, spring, summer and autumn. Furthermore, there is significant spatial heterogeneity of the changing trends for ND- VI, temperature and precipitation at Qinghai-Tibet Plateau scale.


Assuntos
Plantas , Análise Espaço-Temporal , Análise Espectral , Monitoramento Ambiental , Tibet
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