Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 19 de 19
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 27(6): 1966-1972, 2019 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-31839068

RESUMO

OBJECTIVE: To study the mechanism of naoxintong capsule (NXT) -inhibiting peripheral ischemic inflammation. METHODS: Mice were randomly double-blindly divided into 3 groups: sham-operation group, model group and NXT group. Both model and NXT groups underwent the hind limb ischemia (HLI) surgery followed by oral gavage with saline or NXT, respectively, one hour after operation. Three days after operation, the percentages of neutrophils and macrophages in the gastrocnemius muscle were examined by flow cytomety and immunohistochemical method. The changes in gene and protein expressions induced by NXT were examined by real-time PCR and protein chip, respectively. The changes of signaling pathways were analyzed. RESULTS: Compared with sham oparation and model groups, NXT could decrease the ratios of neutrophils and macrophages in gastrocnemius inflammation site (P<0.01), and downregulate the mRNA expression of gene EMR1 (P<0.01). NXT reduced the expression of TNF-α and IL-1ß at both mRNA (P<0.001) and protein levels (P<0.05). The proteomic analysis showed that the use of NXT resulted in the expression changes of 13 proteins. The expression of 6 cytokines was increased, and the secretion of 7 proteins was upregulated. Besides, most of identified 13 proteins were involved in the function regulation of other immune cells. CONCLUSION: NXT can significantly alleviate ischemia-induced peripheral inflammation by reducing the ratio of immune cells and altering the expression patterns of mRNA and protein. The expression changes provide theoretical guidance and the potential targets for the clinical use of NXT in the treatment of ischemia-induced peripheral inflammatory diseases.


Assuntos
Medicamentos de Ervas Chinesas , Inflamação/tratamento farmacológico , Proteômica , Animais , Isquemia , Camundongos , Fator de Necrose Tumoral alfa
2.
J Phys Chem Lett ; 10(13): 3557-3562, 2019 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-31179702

RESUMO

Ultrasensitive mechano-stimuli photoluminescence enhancement was observed in pyramid-like zinc oxide nanoparticles (ZnO NPs), which are fabricated by a facile hydrothermal route. The response of the ZnO NPs to mechanical stimuli is so sensitive that even an ant walking and acoustic vibration can trigger the luminescence enhancement. The mechanism for this unusual behavior was attributed to the electron injection process between crystal boundaries. Thus, this work opens up the possibility of detecting slight mechanical stimuli wirelessly, rapidly, and sensitively. Importantly, the sensitive response of the NPs to sound waves can find potential application in devices for hearing-impaired people.

3.
Dalton Trans ; 48(22): 7910-7917, 2019 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-31086932

RESUMO

Luminescent hybrid materials based on nanodiamonds (NDs) and rare earth ions have been successfully synthesized by covalently modifying NDs with pyromellitic acid (PMA) which is capable of coordinating to Eu3+ and Tb3+ ions. With NDs acting as a host matrix, the PMA and rare earth ions serve as an organic sensitizer and activator, respectively, yielding a highly bright hybrid composite. Interestingly, for the co-doped hybrid composites ND-PMA-Eu/Tb, the intensity ratio of the two emissions, 5D4→7F5 transition (Tb3+) to 5D0→7F2 transition (Eu3+), is linearly related to temperature in the range from 77 K to 277 K. Therefore, the hybrid could be developed as a self-calibrated ratiometric luminescent thermometer due to its temperature-dependent luminescence performance.

4.
Food Chem ; 265: 18-22, 2018 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-29884370

RESUMO

Properties of starches isolated from soft and hard wheat dough after freezing/thawing (F/T) treatment were investigated. Significance of results was observed between isolated hard wheat starch (HWS) and soft wheat starch (SWS), but both cultivars showed an increase in the amounts of damaged starch and leaching proteins, lipids, and amylose with F/T cycles. The freezing-treated HWS exhibited a higher swelling power and peak, trough, breakdown and final viscosity than SWS after F/T treatment. The onset, peak and conclusion gelatinization temperatures and the enthalpy of the isolated HWS determined by differential scanning calorimetry, decreased throughout F/T cycles. Concomitantly, the bread containing freezing-treated HWS exhibited a lower bread specific volume and harder crumb firmness, which might be associated with its significant structural changes induced by F/T treatment.


Assuntos
Congelamento , Amido/química , Triticum/química , Amilose/análise , Pão , Dureza , Amido/metabolismo , Temperatura Ambiente , Viscosidade
5.
J Colloid Interface Sci ; 529: 1-10, 2018 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-29879677

RESUMO

ZnO as an eco-friendly material shows bright luminescence under UV illumination when it is tailored into nanoscale size, which makes it a promising luminescent nanomaterial. However, the poor stability of ZnO hinders its applications drastically. In this work, multi-ZnO-cores@uni-BaSO4-shell (mZnO@uBaSO4) nanocomposite has been prepared through a non-equilibrium sorption process employing ZnO QDs as the "seeds" and BaSO4 as the "valve". The mZnO@uBaSO4 nanocomposite shows improved photo-, thermal- and ambient-stability compare with bare ZnO QDs. The fluorescence efficiency of the mZnO@uBaSO4 nanocomposite decreases little even after 60 h of UV irradiation compare with ZnO QDs. The mZnO@uBaSO4 nanocomposite shows bright luminescence with little decrease even the ambient temperature up to 160 °C and the nanocomposite shows strong resistance to harsh environment. By coating the mZnO@uBaSO4 nanocomposite and commercial phosphors onto UV-chip, light-emitting diode (LED) with correlated color temperature, Commission Internationale de L'Eclairage coordinate, color rendering index and luminous efficiency of 6109 K, (0.32, 0.33), 85 and 47.33 lm/W have been realized, and this will make a great step towards eco-friendly UV-pumped LEDs.

6.
BMC Med Imaging ; 17(1): 44, 2017 07 21.
Artigo em Inglês | MEDLINE | ID: mdl-28732493

RESUMO

BACKGROUND: This study was aimed to evaluate the feasibility and accuracy of real-time three-dimensional echocardiography (RT-3DE) measurement of left atrial (LA) volume and function in comparison with two-dimensional echocardiography (2DE) measurements in atrial fibrillation (AF) patients. METHODS: A total of 50 pairs of AF patients and healthy controls were enrolled in this study. Indexed LA end-diastole volume (ILAEDV) and indexed LA end-systolic volume (ILAESV), as well as LA function indices such as segmental LA ejection fraction (LAEF), were assessed using 2DE Simpson's method and the RT-3DE method. RESULTS: The images showed that regional LA volume-time curves and LAEF were disordered in AF patients. ILAEDV and ILAESV were markedly increased and global LAEF was significantly decreased in AF patients compared with those in healthy controls (P < 0.01). No significant differences were found in ILAEDV, ILAESV, and LAEF levels as determined by the RT-3DE method or 2DE Simpson's method. Bland-Altman analysis showed that the two methods agreed well for measuring ILAEDV, ILAESV, and segmental LAEF. CONCLUSION: The RT-3DE method may be a feasible and accurate method for evaluating LA volume and function of AF patients in clinical practice.


Assuntos
Fibrilação Atrial/diagnóstico por imagem , Fibrilação Atrial/fisiopatologia , Ecocardiografia Tridimensional/métodos , Função do Átrio Esquerdo , Ecocardiografia , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes
7.
Shanghai Kou Qiang Yi Xue ; 25(3): 284-7, 2016 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-27609378

RESUMO

PURPOSE: To analyze the retention of 3 different Co-Cr-Mo alloy clasps on premolars, and provide information for clinical design of aesthetic clasps. METHODS: An EZ20 force measuring instrument was used to record the retention of Co-Cr-Mo alloy casting aesthetic clasps when they were dislodged from undercuts of different depths (0.25, 0.50, 0.75 mm) on premolars. The data were analyzed with SPSS 22.0 software passage. RESULTS: The clasp retention in groups of 0.25 and 0.5 mm undercut was three-arm clasp > varied Y-shaped clasp > modified RPI clasp. In the group of 0.75 mm undercut, the clasp retention was varied Y-shaped clasp>three-arm clasp>modified RPI clasp after circulations. CONCLUSIONS: A varied Y-shaped bar clasp of 0.75 mm undercut depth is suitable for premolar both for its adequate retention and aesthetic effect.


Assuntos
Grampos Dentários , Retenção de Dentadura , Estética , Vitálio/química , Dente Pré-Molar , Ligas de Cromo , Ligas Dentárias , Análise do Estresse Dentário , Prótese Parcial Removível , Humanos
8.
Shanghai Kou Qiang Yi Xue ; 25(6): 663-667, 2016 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-28275786

RESUMO

PURPOSE: To investigate the effects of repeated firing on microleakage of selective laser melting ceramic crowns. METHODS: Fifty molars were randomly divided into 2 groups (25 teeth in each group). Teeth in group A received a chamfer finish line preparation, whereas teeth in group B received a shoulder finish line. After SLM metal crowns were fabricated, all the crowns received initial oxidation step, opaque firing, dentin firing and glaze firing, then crowns in each group were randomly divided into 5 sub-groups according to different time of clinical firings. Glass ionomer was applied for bonding. After 5000 thermocycles ranging from 5degrees centigrade to 55degrees centigrade, all the specimens was evaluated by dye penetration and then microleakage was examined under light microscopy. The data were analyzed with SPSS 20.0 software package. RESULTS: Microleakage between all specimens of group A were not statistically significant (P>0.05) whereas that of group B were statistically significant (P<0.05); After the fifth time of clinical firing, microleakage of specimens in group B(B5) were significantly higher than that of group A(A5). CONCLUSIONS: Repeated firings had no significant influence on marginal microleakage of SLM ceramic crowns whereas the crowns of chamfer finish lines result in better clinical performance after repeated firings.


Assuntos
Coroas , Porcelana Dentária , Lasers , Propriedades de Superfície , Infiltração Dentária , Dentina , Humanos , Teste de Materiais , Cimentos de Resina
9.
Shanghai Kou Qiang Yi Xue ; 25(6): 668-672, 2016 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-28275787

RESUMO

PURPOSE: To evaluate microleakage of SLM Co -Cr alloy metal crown with two types finished line (chamfer and shoulder), compared with conventional fabrication of Co -Cr alloy metal crowns. METHODS: Thirty healthy non-carious human molars were selected and randomly assigned to 3 groups, 10 in each. Teeth in group A and C received a chamfer finish line preparation, whereas teeth in group C received a shoulder finish line. Conventional Co -Cr alloy metal crowns were fabricated for group A when SLM metal crowns were made for group B and group C. Glass ionomer was applied for bonding. After 5000 thermocycles ranging from 5degrees centigrade to 55degrees centigrade,all the specimens were evaluated by dye penetration and then microleakage was examined under light microscope. The data were analyzed statistically with SPSS 20.0 software package. RESULTS: Microleakage in group A was significantly higher than the other two groups, group B and group C showed no significant difference in microleakage while microleakage in group B was higher than that in group C. CONCLUSIONS: Microleakage of SLM metal crowns was significantly less than that of conventional Co-Cr alloy metal crowns; chamfer finish line designs was recommended for SLM metal crowns in consideration of reducing microleakage and protecting tooth.


Assuntos
Coroas , Infiltração Dentária , Adaptação Marginal Dentária , Lasers , Resinas Acrílicas , Humanos , Metais , Dente Molar , Dióxido de Silício
10.
Chirality ; 27(3): 281-5, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25640306

RESUMO

Efficient preparation of (R)-2-chloromandelic acid based on a recycle process of resolution is described. In the process, the desired was obtained by coordination-mediated resolution with D-O,O'-di-(p-toluoyl)-tartaric acid in the presence of Ca(2+) . Meanwhile, the undesired could be racemized in the presence of sodium hydroxide and the product was suitable for further resolution. A carbanion mechanism for the racemization of is proposed.


Assuntos
Ácidos Mandélicos/química , Estereoisomerismo
11.
Shanghai Kou Qiang Yi Xue ; 23(3): 300-3, 2014 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-25102871

RESUMO

PURPOSE: To investigate the effect of different surface treatments on the shear bond strength of zirconia substructure and veneering ceramic. METHODS: Kavo zirconia specimens were divided into 4 groups (each group contains 8 specimens) according to different surface treatments: Group A was pigmented by dipping presintered blocks in the coloring solution VITA LL5, and not treated with abrasion after firing; Group B was pigmented with the same solution and then dealt with abrasion; Group C was not treated by any methods and Group D was only dealt with abrasion. All the veneering ceramics were fired on the zirconia substructure by slip-casting technique and the shear bond strength of zirconia substructure and veneering ceramic were tested. The data was analyzed statistically with SPSS 10.0 software package. RESULTS: The shear bond strength of the abrasive-treated groups (group B and group D) was significantly higher than the other two groups, but no significant difference was found between pigmented-treated groups (group A and group C) and non-pigmented-treated groups (group B and group D). CONCLUSIONS: Abrasion can increase the shear bond between Kavo zirconia substructure and veneering ceramics while pigmentation has no significant effect on the bonding strength.


Assuntos
Cerâmica , Porcelana Dentária , Colagem Dentária , Análise do Estresse Dentário , Facetas Dentárias , Teste de Materiais , Resistência ao Cisalhamento , Propriedades de Superfície , Zircônio
12.
Shanghai Kou Qiang Yi Xue ; 23(2): 204-8, 2014 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-24935845

RESUMO

PURPOSE: To evaluate the effect of fiber reinforcement composites (FRC) in treating chronic periodontitis with dentition defect. METHODS: Thirty patients who had chronic periodontitis and missed less than 2 lower anterior teeth were chosen. After appropriate periodontal treatment, EverStick fibers were used to fabricate splint with the missing teeth repaired. One month, 6 months, 1 year and 2 years after treatment, periodontal indexes such as plaque index (PLI), gingival index (GI) and probe depth (PD) were recorded and the patients' satisfaction was evaluated. SPSS 17.0 software package was used for statistical analysis. RESULTS: The results showed that no significant difference was found in PLI and GI during observation period (P>0.05). PD decreased significantly after 6 months of observation (P<0.05). Patients' satisfaction degree for aesthetics, pronunciation, comfort and function was beyond 80%. CONCLUSIONS: Using FRC technique in chronic periodontitis with dentition defect can effectively fix the loosen teeth and maintain physical function. Appropriate periodontal treatment every 6 months is the key factor for satisfactory results.


Assuntos
Periodontite Crônica , Perda da Inserção Periodontal , Índice de Placa Dentária , Dentição , Humanos , Índice Periodontal , Periodontite
13.
Shanghai Kou Qiang Yi Xue ; 23(1): 46-50, 2014 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-24608612

RESUMO

PURPOSE: To compare the stress distribution of supporting tissues in Atwood level 3 alveolar bones under the mandibular complete dentures with and without denture adhesives. METHODS: Photoelastic models of epoxy were fabricated according to the standard Atwood level 3 edentulous model. 1.5 kg force was vertically applied on the bite force loading device. After stress frozen, photoelastic model slices in posterior teeth area were observed and analyzed. RESULTS: When using denture adhesives, stresses distributed more adequately in the buccal and lingual side and the force of alveolar crest increased remarkably. CONCLUSIONS: To those with Atwood level 3 alveolar ridge and complete denture, denture adhesives can not only increase stability but also prevent local pressure under uneven stress distribution.


Assuntos
Cimentos Dentários , Mandíbula , Força de Mordida , Dentaduras , Humanos
14.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 47(7): 427-30, 2012 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-22931575

RESUMO

OBJECTIVE: To investigate the marginal adaptation of crowns fabricated by selective laser melting (SLM) and wax-lost-casting method, so as to provide an experimental basis for clinic. METHODS: Co-Cr alloy full crown were fabricated by SLM and wax-lost-casting for 24 samples in each group. All crowns were cemented with zinc phosphate cement and cut along longitudinal axis by line cutting machine. The gap between crown tissue surface and die was measured by 6-point measuring method with scanning electron microscope (SEM). The marginal adaptation of crowns fabricated by SLM and wax-lost-casting were compared statistically. RESULTS: The gap between SLM crowns were (36.51 ± 2.94), (49.36 ± 3.31), (56.48 ± 3.35), (42.20 ± 3.60) µm, and wax-lost-casting crowns were (68.86 ± 5.41), (58.86 ± 6.10), (70.62 ± 5.79), (69.90 ± 6.00) µm. There were significant difference between two groups (P < 0.05). CONCLUSIONS: Co-Cr alloy full crown fabricated by wax-lost-casting method and SLM method provide acceptable marginal adaptation in clinic, and the marginal adaptation of SLM is better than that of wax-lost-casting method.


Assuntos
Ligas de Cromo , Coroas , Técnica de Fundição Odontológica , Adaptação Marginal Dentária , Planejamento de Prótese Dentária , Projeto Auxiliado por Computador , Congelamento , Lasers
15.
Zhonghua Wai Ke Za Zhi ; 50(4): 353-6, 2012 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-22800791

RESUMO

OBJECTIVE: To explore the potential role of miR-195 on invasiveness and prognosis of breast cancer. METHODS: The RNA in formalin-fixed paraffin embedded (FFPE) of 88 breast cancer patients with primary tumors was extracted, and miR-195 levels were quantified by quantitative real-time polymerase chain reaction (real-time PCR). The relationship of miR-195 levels and clinicopathological variables were assessed by Mann Whitney-U test. Recurrence-free survival and overall survival curves were derived from Kaplan-Meier estimates and the curves were compared by Log-rank tests. Cox regression analysis was used for multivariate analysis. All statistical tests were two-sided. RESULTS: The levels of miR-195 in the breast cancer with histological high grade, tumor size of T3-4, lymph nodal involvement or vessel invasion were significantly down-regulated, compared with those of patients with histological low grade (Z = -2.271, P = 0.023), tumor size of T1-2 (Z = -2.687, P = 0.007), no lymph node metastasis (Z = -1.967, P = 0.049) and vessel invasion (Z = -2.432, P = 0.015). In addition, no statistically significant difference (P > 0.05) was identified between miR-195 levels and hormone receptors status, HER-2 expression, TNM stage, tumor types, recurrence and menstrual status. When considering 2(-ΔCt) = 0.270 (median level) as cut-off value, Kaplan-Meier survival analysis indicated that patients with high miR-195 level showed a positive association towards a longer survival, either recurrence-free survival (χ(2) = 5.985, P = 0.014) or overall survival (χ(2) = 30.05, P = 0.000). In a multivariate analysis, miR-195 expression on FFPE correlated significantly with outcomes of breast cancer (HR = 0.040, 95%CI: 0.009 - 0.179, P = 0.000) and was independent of other prognostic factors. CONCLUSIONS: It suggests that miR-195 expression on FFPE is inversely correlated with histological high grade, bigger tumor size, lymph node involvement, vessel invasion. Furthermore, as independent prognostic factor, low miR-195 significantly contributes to poor outcomes of breast cancer.


Assuntos
Neoplasias da Mama/patologia , MicroRNAs/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/genética , Feminino , Humanos , Estimativa de Kaplan-Meier , Metástase Linfática , Pessoa de Meia-Idade , Análise Multivariada , Prognóstico , RNA Neoplásico/genética
16.
Zhonghua Wai Ke Za Zhi ; 50(1): 53-6, 2012 Jan 01.
Artigo em Chinês | MEDLINE | ID: mdl-22490292

RESUMO

OBJECTIVE: To explore effect of polymorphism rs1563828 (C > T) in human murine double minute 4 gene (MDM4) on genetic susceptibility for early-onset breast cancer and potential association with age of onset of breast cancer. METHODS: One hundred and twenty-four early-onset breast cancer patients (age ≤ 35 years at time of diagnosis) from independent families admitted from January 2006 to June 2010 and 101 age-matched healthy control subjects were analyzed. Genotype analysis was conducted by polymerase chain reaction and then MALDI-TOF-MS assay. Association of genotype distribution and breast cancer risk was evaluated by χ(2) test. The odd-ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional Logistic regression model. The t test was used to compare the age and demographic differences among groups. RESULTS: The frequency of rs1563828 polymorphism genotypes in control group were CC 43.6% (44/101), CT 42.6% (43/101), TT 13.9% (14/101), and in case group were 42.7% (53/124), 46.0% (57/124), 11.3% (14/124), respectively. No significant difference (χ(2) = 0.449, P = 0.799) was reached by χ(2) test. rs1563828CT or TT genotype does not confer a significantly increased risk for breast cancer compared with CC genotype after adjusting for age, menarche in Logistic regression analysis (OR = 1.024, 95%CI: 0.581 - 1.806, P = 0.934). TT carriers were observed to develop breast cancer earlier than CC/CT carriers [(30 ± 4) years vs. (32 ± 3) years, P = 0.028]. CONCLUSIONS: The rs1563828(C > T) polymorphism in MDM4 gene may not confer risk to breast cancer, especially for early-onset breast cancer patients. Homozygous TT of rs1563828 is associated with younger age to develop breast cancer.


Assuntos
Neoplasias da Mama/genética , Proteínas Nucleares/genética , Polimorfismo de Nucleotídeo Único , Proteínas Proto-Oncogênicas/genética , Adulto , Idade de Início , Neoplasias da Mama/epidemiologia , Estudos de Casos e Controles , Proteínas de Ciclo Celular , Feminino , Predisposição Genética para Doença , Humanos , Modelos Logísticos , Fatores de Risco
17.
Shanghai Kou Qiang Yi Xue ; 21(1): 31-5, 2012 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-22431043

RESUMO

PURPOSE: To analyze the stress distribution and displacement of the mandibular alveolar mucosa under functional impressive complete denture. METHODS: CT images were processed by Mimics and Geomagic studio, and the solid models and 3-D finite element models were established by Unigraphics NX. 3-D finite element analysis (3-D FEA) was used to study the stress distribution and displacement on the mandibular alveolar mucosa under functional impressive complete denture and anatomic impressive complete denture. RESULTS: The stress distribution on the mandibular alveolar mucosa under two types of complete denture were consistent, and arranged from large to small order as follow: alveolar process crest of molar area, alveolar process crest of anterior area, external oblique ridge and internal oblique ridge. At alveolar process crest and internal oblique ridge, the stress and Z-axis displacement of functional impressive complete denture were less than those of anatomic impressive complete denture. CONCLUSIONS: During masticatory period, the stress distribution on the mandibular alveolar mucosa under functional impressive complete denture is more even and more comprehensive than that under anatomic one.


Assuntos
Prótese Total , Análise de Elementos Finitos , Processo Alveolar , Humanos , Mandíbula , Dente Molar , Membrana Mucosa
18.
Zhonghua Wai Ke Za Zhi ; 50(11): 1011-4, 2012 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-23302487

RESUMO

OBJECTIVE: To investigate the potential use of miR-155 as novel breast cancer biomarker. METHODS: There were 88 breast cancer patients underwent modified mastectomy and had detailed clinical follow-up information. Extracting RNA from the formalin-fixed paraffin embedded (FFPE) samples, miR-155 levels were quantified by real-time-PCR. miR-155 levels among clinico-pathological variables were accessed by Mann Whitney-U test. Overall survival curve was derived from Kaplan-Meier estimates and the curve was compared by Log-rank test. Cox regression analysis was used for multivariate analysis. All statistical tests were two-sided. RESULTS: Significantly higher miR-155 level was found in tumor tissue compared to paired normal tissue (t = 6.75, P = 0.000). A potential relationship between miR-155 levels and existing clinico-pathological parameters of breast cancer, such as menstrual status, tumor size, nodal involvement, stage of disease, hormone receptor status, HER-2 status, histological grade or tumor subtype was investigated. Up-regulated miR-155 level was observed in breast cancer with lymph node metastasis, pT3+4, advanced TNM stage, HER-2 positive and with vascular invasion (Z = -6.320 to -2.041, P = 0.000 to 0.041). When considering 2(-ΔCt) = 4.87 (median level) as cut-off value, patients with miR-155 up-regulation showed a positive association towards a shorter overall survival (χ(2) = 6.396, P = 0.011). In Cox multivariate analysis, miR-155 expression on FFPE was shown an inverse trend for outcomes of breast cancer (HR = 1.58, 95%CI: 0.87 - 3.16, P = 0.082). CONCLUSIONS: miR-155, as an oncomir, promotes lymph node involvement and vascular invasion and accompanies over-expressed HER-2 on breast cancer FFPE tissue. It suggests that miR-155 could predict the invasiveness.


Assuntos
Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , MicroRNAs/metabolismo , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Pessoa de Meia-Idade , Invasividade Neoplásica , Prognóstico , Reação em Cadeia da Polimerase em Tempo Real
19.
Shanghai Kou Qiang Yi Xue ; 20(1): 106-8, 2011 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-21451910

RESUMO

PURPOSE: To evaluate the clinical effect of laser-welded crowns and bridges. METHODS: Two hundred defective crowns and bridges were welded by using Heraplus laser welding machine, and then restored by porcelain. RESULTS: After being welded ,those defective crowns and bridges of different materials fit well and their marginal areas were also satisfactory. During the follow up period of one year, no fractured porcelain and crack were found at welding spots. CONCLUSIONS: The technology of laser welding has no direct effect on welding spots between metal and porcelain and could be used to deal with the usual problems of the crowns and bridges.


Assuntos
Porcelana Dentária , Soldagem em Odontologia , Coroas , Humanos , Lasers , Metais , Soldagem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA