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1.
Chemistry ; 2019 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-31529655

RESUMO

Cuprous oxide microcrystals with {111}, {111}/{100}, and {100} exposed facets were synthesized. ³¹P MAS NMR using trimethylphosphine as the probe molecule was employed to study the acidic properties of samples. It was found that the total acidic density of samples increases evidently after sulfation compared with the pristine cuprous oxide microcrystals. During sulfation, new {100} facets are formed at the expense of {111} facets and lead to the generation of two Lewis acid sites due to the different binding states of SO4²- on {111} and {100} facets. Moreover, DFT calculation was used to illustrate the binding models of SO4²- on {111} and {100} facets. Also, Pechmann condensation reaction was applied to study the acidic catalytic activity of these samples. It was found that the sulfated {111} facet has better activity due to its higher Lewis acid density compared with the sulfated {100} facet.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31538763

RESUMO

Developing anodes with a high and stable energy density for both gravimetric and volumetric storage is vital for high-performance lithium/sodium-ion batteries. Herein, an SnSe/few-layered graphene (FLG) composite with a high tap density (2.3 g cm-3) is synthesized via the plasma-milling method, in which SnSe nanoparticles are strongly bound with the FLG matrix, owing to both Sn-C and Se-C bonds, to form nanosized primary particles and then assemble to microsized secondary granules. The FLG can effectively alleviate the large stress generated from the volume expansion of SnSe during cycling based on its superstrength. Furthermore, as demonstrated by the density-functional theory calculations, the Sn-C and Se-C co-bonding benefitting from the formation of substantial vacancy defects on the P-milling-synthesized FLG enables strong affinity between SnSe nanoparticles and the FLG matrix, preventing SnSe from aggregating and detaching even after long-term cycling. As an anode for lithium-ion batteries, it exhibits high gravimetric and volumetric capacities (864.8 mAh g-1 and 1990 mAh cm-3 at 0.2 A g-1), a high rate (612.6 mAh g-1 even at 5.0 A g-1), and the longest life among the reported SnSe-based anodes (capacity retention of 92.8% after 2000 cycles at 1.0 A g-1). Subsequently, an impressive cyclic life (capacity retention of 91.6% after 1000 cycles at 1.0 A g-1) is also achieved for sodium-ion batteries. Therefore, the SnSe/FLG composite is a promising anode for high-performance lithium/sodium-ion batteries.

3.
Front Immunol ; 10: 1709, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31396224

RESUMO

Human leukocyte antigen (HLA) alleles have a high degree of polymorphism, which determines their peptide-binding motifs and subsequent T-cell receptor recognition. The simplest way to understand the cross-presentation of peptides by different alleles is to classify these alleles into supertypes. A1 and A3 HLA supertypes are widely distributed in humans. However, direct structural and functional evidence for peptide presentation features of key alleles (e.g., HLA-A*30:01 and -A*30:03) are lacking. Herein, the molecular basis of peptide presentation of HLA-A*30:01 and -A*30:03 was demonstrated by crystal structure determination and thermostability measurements of complexes with T-cell epitopes from influenza virus (NP44), human immunodeficiency virus (RT313), and Mycobacterium tuberculosis (MTB). When binding to the HIV peptide, RT313, the PΩ-Lys anchoring modes of HLA-A*30:01, and -A*30:03 were similar to those of HLA-A*11:01 in the A3 supertype. However, HLA-A*30:03, but not -A*30:01, also showed binding with the HLA*01:01-favored peptide, NP44, but with a specific structural conformation. Thus, different from our previous understanding, HLA-A*30:01 and -A*30:03 have specific peptide-binding characteristics that may lead to their distinct supertype-featured binding peptide motifs. Moreover, we also found that residue 77 in the F pocket was one of the key residues for the divergent peptide presentation characteristics of HLA-A*30:01 and -A*30:03. Interchanging residue 77 between HLA-A*30:01 and HLA-A*30:03 switched their presented peptide profiles. Our results provide important recommendations for screening virus and tumor-specific peptides among the population with prevalent HLA supertypes for vaccine development and immune interventions.

4.
J Diabetes Investig ; 2019 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-31172682

RESUMO

AIMS/INTRODUCTION: The worldwide prevalence of diabetes mellitus has been increasing over the past decades, particularly in developing countries. Because of the lack of information regarding changes in diabetes mellitus prevalence, awareness, treatment and control in rural China, we assessed these trends - overall and in the context of related health conditions - to explore the impact of these primary health issues on these rates in a poorly educated, rural population. MATERIALS AND METHODS: Diabetes mellitus prevalence, awareness, treatment and control rates were compared between two surveys carried out in 1992 and 2011. The residents of three villages, aged 35-64 years, were recruited for this study. RESULTS: In 1992, 1,091 individuals were interviewed and, in 2011, 2,338 individuals were interviewed. Between the two surveys, the overall diabetes mellitus prevalence in the study population was lower in 1992 than that in 2011 (P < 0.001); among men, the prevalence was 5.2-fold higher in 2011 than in 1992 (10.5 vs 1.7%) and nearly 4.3-fold higher (11.2 vs 2.1%) among women. Men aged 35-44 years, with >6 years of education, stage I hypertension and being overweight, had a higher prevalence of diabetes mellitus in 2011 than in 1992. Similarly, for the same time periods, there was also a higher diabetes mellitus prevalence among women aged 55-64 years, with 1-6 years of education, stage III hypertension and who were overweight. However, there were no significant changes in diabetes mellitus awareness, treatment or control in this population. CONCLUSIONS: These results suggest that particular efforts must be made to enhance diabetes mellitus prevention, control and public awareness in rural communities in China.

5.
J Environ Manage ; 245: 114-121, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31150902

RESUMO

Particulate matter (PM) in the atmosphere is a threat to human health. Wetland plants were confirmed to accumulate particles on the leaf surface; at the same time, rainfall could wash-off particles and accelerate the whole removal process, however, the dynamic processes occurring during rainfall events on wetland plants remain unclear. In order to provide sustainable strategies for authorities to take measures, we need to figure out how to reduce PM on leave surface by artificial rainfall efficiently. Four wetland species (Scirpus validus, Typha orientalis, Phragmites australis, and Iris wilsonii) were selected to examine for leave surface accumulation and simulate the experiment. We estimated the wash-off ability of rainfalls with three different intensities (15, 30, and 60 mm h-1) and determined the proportions of different PM size-fractions washed by the rains. The results showed that particles accumulated on the surface could be washed off efficiently (78% ∼ 89%) by the simulated rainfalls. The removal rates were high in the first 30 min and large particles comprised a large proportion of the removed particles. The rainfall with the intensity of 30 mm h-1 removed the most particles among three different rainfall intensities. When the rainfall intensity increased, fine particles (PM2.5) could be washed off more easily. Moreover, with a thinner wax layer, fine particles on wetland plants' leaf surfaces might be more easily removed by the rains. While wash off the plants, spraying rains with the intensity of 30 mm h-1 for about 30 min every time (high intensity with shorter time) may be particle removal efficiency.


Assuntos
Material Particulado , Áreas Alagadas , Cidades , Plantas , Chuva
6.
Cancer Epidemiol Biomarkers Prev ; 28(9): 1454-1460, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31239266

RESUMO

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) accounts for the highest incidence rate worldwide and is responsible for the fourth leading cause of cancer-related death. Currently, serologic biomarkers for early ESCC diagnosis are needed for timely treatment. METHODS: The performance of a four-autoantibody panel (i.e., anti-TP53, HRAS, CTAG1A, and NSG1) was evaluated by ELISA for the early diagnosis of ESCC with 569 retrospective serum samples. A training set comprising 129 patients with early-stage ESCC, 130 patients with esophageal benign lesion (EBL), and 150 healthy controls (HC) was used to develop an early ESCC predictive model. Data obtained from an independent validation set were used to evaluate and validate the predictive model to distinguish the early ESCC from the controls (EBL+HC). Finally, a multiplexed assay based on the Luminex xMAP technology platform was developed to enable simultaneous detection of the four-autoantibody panel using the validation set. RESULTS: The four-autoantibody panel significantly discriminated early ESCC cases from the controls with 62.8% sensitivity at 88.9% specificity in the training set and with 58.0% sensitivity at 90.0% specificity in the independent validation set. The results of the multiplexed assay using xMAP technology for early ESCC showed a significant correlation with that of the ELISA assays with 66.0% sensitivity at 90.9% specificity. CONCLUSIONS: A four-autoantibody panel showed good performance for early ESCC diagnosis with ELISA and could be further developed into a multiplex assay using the Luminex xMAP technology. IMPACT: The four-autoantibody panel could be used for serologic screening for early ESCC.

7.
DNA Cell Biol ; 38(6): 572-582, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31144988

RESUMO

Pieces of evidence have shown that cytoskeleton regulator RNA (CYTOR), a long noncoding RNA (lncRNA), played a pivotal role in development and progression of a variety of cancers. In contrast, further research is needed to study the clinical significance and the detailed mechanism of action of lncRNA-CYTOR in colorectal cancer (CRC). This study aimed to investigate the clinical significance of CYTOR in CRC prognosis and identify the relevant potential signaling pathways and underlying mechanism of competing endogenous RNA. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) indicated that the expression of CYTOR was significantly elevated in CRC tumor tissues and cell lines. Aberrant expression of CYTOR was significantly related to TNM stage, T stage, N stage, and perineural and venous invasions. Survival analysis indicated that high-CYTOR expression was associated with poor overall survival in CRC patients (p = 0.0057), and multivariate analysis showed that high-CYTOR expression was an independent prognostic factor, which led to poor OS. In addition, bioinformatics analysis revealed that there were 18 microRNAs (miRNAs) interacted with CYTOR, and one of them, miR-3679-5p might collaborate with metastasis-associated in colon cancer-1 (MACC1), which was selected for further analysis. Pearson correlation analysis showed a significant positive correlation between the expression levels of CYTOR and MACC1. In conclusion, this study suggested that lncRNA-CYTOR played an important role in tumorigenesis and development through the CYTOR/miR-3679-5p/MACC1 axis.


Assuntos
Neoplasias Colorretais/metabolismo , RNA Longo não Codificante/metabolismo , Fatores de Transcrição/metabolismo , Linhagem Celular , Linhagem Celular Tumoral , Neoplasias Colorretais/genética , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Feminino , Humanos , Masculino , MicroRNAs/metabolismo , Pessoa de Meia-Idade , Oncogenes , Prognóstico , Transdução de Sinais , Regulação para Cima
8.
Chem Commun (Camb) ; 55(45): 6405-6408, 2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31094368

RESUMO

A synthetic strategy with the visible-light photo-catalytic synergistic combination of electron and energy transfer processes has been developed. The mild reaction conditions allow the radical-radical cross-coupling phenomenon for the multicomponent synthesis of ß-arylsulfonyl(diarylphosphinoyl)-α,α-diarylethyl-amines from readily available arylsulfinic acids (diarylphosphine oxides), 1,1-diarylethylenes and arylazides.

9.
BMC Health Serv Res ; 19(1): 314, 2019 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-31096967

RESUMO

BACKGROUND: The early initiation of antiretroviral therapy (ART) for people living with HIV (PLWH) benefits both individuals and societies. However, little is known about the intention to initiate ART among PLWH in China in the context of a scaling-up of treatment or how the recommendations of healthcare workers affect this intention. METHODS: A total of 451 ART-naïve PLWH were recruited from communities in Guangzhou, China for this study. Data were collected by trained physicians via face-to-face interviews. Logistic regression models were fitted for the data analyses. RESULTS: Of the participants, 93.8% were male, 72.7% were infected via homosexual behaviour and 68.5% reported an intention to initiate ART. In the latter category, 77.8, 41.9 and 20.0% of respondents received strong recommendations to initiate ART from healthcare workers at the Centres for Disease Control and Prevention (CDC), community healthcare centres and non-governmental organisations (NGOs), respectively. After adjusting for potential confounders, depression, anxiety and strong recommendations from healthcare workers at the CDC and NGOs correlated significantly with ART intention. In the adjusted final hierarchical logistic regression model, the duration of infection [multivariate odds ratio (ORm) = 0.30, p < 0.001], route of HIV infection (ORm = 0.18, p < 0.01), infection status of the current spouse/regular sex partner (ORm = 0.21-0.23, p < 0.01), anxiety (ORm = 2.44-2.65, p < 0.05) and strong recommendations from CDC physicians (ORm = 3.67, p < 0.01) or NGOs workers (ORm = 3.67, p < 0.01) were independently associated with the ART intention, whereas a recommendation from a community healthcare centre physician was not. CONCLUSIONS: In Guangzhou, the prevalence of ART intention was below the 90-90-90 targets. Further studies aimed at an in-depth understanding and encouragement of health care workers' perceptions regarding early ART are warranted as a means of scaling up new ART strategies.


Assuntos
Antirretrovirais/uso terapêutico , Infecções por HIV/tratamento farmacológico , Pessoal de Saúde , Intenção , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China , Estudos Transversais , Feminino , Infecções por HIV/psicologia , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Parceiros Sexuais , Fatores Socioeconômicos , Adulto Jovem
10.
Environ Sci Pollut Res Int ; 26(18): 18304-18315, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31041710

RESUMO

Litter decomposition is a complex process that is influenced by many different physical, chemical, and biological processes. Environmental variables and leaf litter quality (e.g., nutrient content) are important factors that play a significant role in regulating litter decomposition. In this study, the effects of adding fungi and using different mesh size litter bags on litter (Populus tomentosa Carr. and Salix matsudana Koidz.) decomposition rates and water quality were investigated, and investigate the combination of these factors influences leaf litter decomposition. Dissolved oxygen (DO), chemical oxygen demand (COD), total phosphorus (TP), and ammonia-nitrogen (NH3-N) were measured during the 112-day experiment. The salix leaf litter (k = 0.045) displayed faster decomposition rates than those of populous leaf litter (k = 0.026). Litter decomposition was initially slow and then accelerated; and by the end of the experiment, the decomposition rate was significantly higher (p = 0.012, p < 0.05) when fungi were added to the treatment process compared to the blank, and litter bags with different mesh sizes did not influence the decomposition rate. The variations in the decomposition rates and nutrient content were influenced by litter quality and a number of environmental factors. The decomposition rate was most influenced by internal factors related to litter quality, including the N/P and C/P ratios of the litter. By quantifying the interact effect of environment and litter nutrient dynamic, to figure out the revetment plant litter decomposition process in a wetland system in biological physical and chemical aspects, which can help us in making the variables that determine decomposition rates important for assessing wetland function.


Assuntos
Biodegradação Ambiental , Fungos/fisiologia , Folhas de Planta , Populus , Salix , Qualidade da Água , Áreas Alagadas , China , Ecossistema , Vidro , Nitrogênio/análise , Tamanho da Partícula , Fósforo/análise , Folhas de Planta/química , Microbiologia do Solo
11.
Nanoscale ; 11(18): 9103-9114, 2019 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-31025996

RESUMO

Metal halide perovskite quantum dots (PQDs) have become the most promising optoelectronic material in new generation displays and lighting devices due to their excellent optical properties. However, their stability and surface defects have affected their large-scale applications. We demonstrate enhanced stability of high-surface-area colloidal PQDs encapsulated with long-chain organic polymer poly(ethylene oxide) (PEO) via simply mixing the PQDs with this high molecular-weight polymer. The introduction of the polymer deactivates the surface defects of PQDs and sufficiently protects the organic ligands on the surfaces of PQDs with obviously improved ambient stability and photoluminescence quantum yield. Moreover, the use of PEO efficiently confines electrons within the PQD emission layer and generates extremely stable green electroluminescence spectra in MAPbBr3 light-emitting diodes (LEDs) over a wide voltage operation range of 5-12 V, accompanied by significant improvements in external quantum efficiencies with enhancement factors of 18.3 times. Our work provides a robust platform for the fabrication of stable PQDs, high-quality PQD films and efficient PQD-based LEDs.

12.
Virol J ; 16(1): 47, 2019 04 16.
Artigo em Inglês | MEDLINE | ID: mdl-30992019

RESUMO

BACKGROUND: Hepatitis C virus (HCV) infection is one of the leading causes of liver cancer, creating enormous economic and social burdens. The Chinese government recommends routine screening of inpatients for HCV before invasive procedures to prevent iatric infections. However, the diagnosis and treatment rates for HCV remain low. The aim of this study was to use available routine screening data to understand the HCV screening of inpatients in different regions of China. METHODS: Inpatient information and HCV screening results were collected from January 2016 to December 2016 at eight tertiary hospitals in different regions of China to compare the HCV-positivity of hospitalized patients among different regions and age groups. RESULTS: The HCV screening rate of inpatients was more than 50%. A total of 467,008 inpatients were enrolled in the study (51.20% were male), and the HCV antibody (anti-HCV) -positive rate was 0.88% (95% confidence interval [CI], 0.85-0.91%) among the total population. This rate was significantly higher among all males compared with all females (0.91% vs 0.85%). Moreover, the HCV antibody-positive rate increased with age and was highest for the 60-64-year age group. Notably, 90.14% (3722/4129) of the anti-HCV seropositive patients were 40 years of age or older. HCV screening for people over 40 years old is recommended. CONCLUSIONS: This study highlights the key role of routine examination for HCV infection in hospitalized patients. Full use of inpatient screening results to manage HCV antibody-positive patients and a screening strategy targeting inpatients 40 years and older were found to be low-cost and effective, which will help to find the missing millions of yet unaware patients and also accelerate the elimination of HCV in China.


Assuntos
Hepatite C/diagnóstico , Programas de Rastreamento/estatística & dados numéricos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Hepatite B/imunologia , Hepatite C/tratamento farmacológico , Hepatite C/epidemiologia , Anticorpos Anti-Hepatite C/sangue , Hospitalização/estatística & dados numéricos , Hospitais , Humanos , Lactente , Recém-Nascido , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/virologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco , Centros de Atenção Terciária/estatística & dados numéricos , Adulto Jovem
13.
Sci Adv ; 5(4): eaaw0446, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31032418

RESUMO

The importance of conical intersections (CIs) in electronically nonadiabatic processes is well known, but their influence on adiabatic dynamics has been underestimated. Here, through combined experimental and theoretical studies, we show that CIs induce a barrier and regulate conversion from a precursor metastable intermediate (CI-R) to a deep well one. This results in bond-selective activation, influencing the adiabatic dynamics markedly in the C(1D) + HD reaction. Theory is validated by experiment; quantum dynamics calculations on highly accurate ab initio potential energy surfaces yield rate coefficients and product branching ratios in excellent agreement with the experiment. Quasi-classical trajectory calculations reveal that the CI-R intermediate leads to unusual reaction mechanisms (designated as C─H activation complex conversion and cyclic complex), which are responsible for large branching ratios. We also reveal that CI-R intermediates exist in other reactive systems, and the dynamical effects uncovered here may have general significance.

14.
Ecotoxicol Environ Saf ; 176: 50-57, 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-30921696

RESUMO

A potent bacterial strain capable of degrading dibenzothiophene (DBT) was isolated and evaluated for its characteristics. The strain, designated as LKY-5, is rod-shaped, gram-negative, and occurs mainly in clusters. It was identified as belonging to the Pseudomonas genus based on the 16S rDNA sequence and phylogenic analysis. Determination of its DBT depletion efficiency by gas chromatography revealed that the isolate was able to completely degrade up to 100 mg L-1 DBT within 144 h. The pH values, DBT concentrations, and biomasses in the medium varied significantly in the initial 24 h. A biosurfactant produced by LKY-5 was extracted and identified as a di-rhamnolipid with the formula Rha-Rha-C8-C8:1 by HPLC-ESI-MS/MS. There were 26 metabolites in the DBT degradation process. Pseudomonas sp. LKY-5 exhibited unusually high DBT degradation efficiency via multiple metabolic pathways. Compared with the reported 4S and Kodama pathways, two more expanded metabolic pathways for the degradation of DBT are proposed. The polycyclic aromatic sulfur heterocycles (PASHs) in diesel, such as C1-DBT, C2-DBT, C3-DBT, 4,6-DMDBT, and 2,4,6-TMDBT, can also be degraded with 28.2-42.3% efficiency. The results showed that LKY-5 is an excellent bacterial candidate for the bioremediation of PASH-contaminated sites and sediments.


Assuntos
Biodegradação Ambiental , Pseudomonas/metabolismo , Tiofenos/metabolismo , Cromatografia Gasosa , Cromatografia Líquida de Alta Pressão , DNA Ribossômico/química , Hidrocarbonetos Aromáticos , Filogenia , Pseudomonas/genética , Pseudomonas/isolamento & purificação , Enxofre/metabolismo , Tensoativos/metabolismo , Espectrometria de Massas em Tandem , Tiofenos/análise , Tiofenos/química
15.
Aging (Albany NY) ; 11(6): 1686-1694, 2019 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-30888967

RESUMO

Recent data on the incidence and trends for recurrent strokes in China are scarce. We assessed the temporal trends in recurrent stroke incidence using in rural China. The age-standardized incidences of recurrent stroke, within 5 years of the incident stroke event, were estimated for 3 time periods: 1992-1998, 1999-2005, and 2006-2012. Among the 768 documented incident stroke cases, 26.3% of the patients experienced recurrent stroke within 5 years. The overall age-adjusted recurrent stroke incidence was 43.93 per 100,000 person-years (1992-2012). During the 2006-2012 period, the recurrent stroke incidence per 100,000 person-years was 107.79 in men, and 557.76 in individuals ≥65 years old. There were significant upward tendencies observed in this population across sex, age, or type of stroke (except for among individuals ≥65 years old with incident intracerebral hemorrhages). Compared with the recurrent stroke incidence observed in the 1992-1998 period, that observed during the 2006-2012 period was more than 3-fold higher; the greatest increase (6.8-fold) was observed in women. These findings suggest an urgent need to improve risk factor management and implement appropriate medical resources to contain this upward trend in recurrent stroke incidence and reduce the overall stroke burden in China.

16.
Cancer ; 2019 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-30825395

RESUMO

BACKGROUND: Colonoscopy adherence among populations at high risk for colorectal cancer (CRC) is crucial for the early diagnosis and treatment of CRC, but the adherence rate has been found to be poor. A short message service (SMS) is effective in promoting cancer screening, but its effectiveness in promoting colonoscopy among populations at high risk for CRC has not been well studied. METHODS: In this randomized controlled trial conducted in Guangzhou, China, participants who had tested positive during preliminary CRC screening (a high-risk factor questionnaire and/or an immunochemical fecal occult blood test) but had not undergone colonoscopy were randomized into low-frequency (monthly) intervention, high-frequency (biweekly) intervention, and control groups. The 2 intervention groups received behavioral theory-based SMS for 6 months. Data were obtained from the CRC screening database. The outcome was undergoing a colonoscopy examination. RESULTS: For the 1362 participants, the rates of colonoscopy adherence were 5.2%, 6.0%, and 10.5% at month 3 and 7.1%, 9.6%, and 13.7% at month 6 in the control, low-frequency intervention, and high-frequency intervention groups, respectively. After adjustments for potential confounders, the high-frequency intervention group was approximately twice as likely as the control group to undergo colonoscopy (adjusted hazard ratio, 1.99; 95% confidence interval, 1.32-3.01), whereas the difference between the low-frequency intervention and control groups was not statistically significant. The cost of SMS to increase colonoscopy uptake by 1 in the high-frequency intervention group was US $2.7. CONCLUSIONS: Text messages sent biweekly for 6 months to patients with positive preliminary screening results could increase colonoscopy adherence. SMS could be a prioritized intervention for promoting colonoscopy in large community-based populations.

17.
Bioresour Technol ; 280: 88-94, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30763865

RESUMO

In this study, two strains Halomonas and Aneurinibacillus were mixed in equal proportions as free cells that could degrade diesel and produce biosurfactant. A new type of immobilized cells, free cells immobilized in beads combined with sodium alginate and straw, was studied. The components of straw-alginate beads were optimized by Response Surface Method, and the degradation performance of immobilized cells was determined. The result indicated that the density, strength and broken rate of straw-alginate beads were 1.04 g/cm3, 216 g and 4%, respectively. The best degradation rate of immobilized cells in straw-alginate beads could be 68.68%. Lately, by analyzing the Monod model, vmax (maximum specific degradation rate of diesel) and KS (half saturation rate constant) of immobilized cells in straw-alginate beads were 1.84 d-1 and 3.23 g/L, respectively, which explained the higher degradation performance.


Assuntos
Alginatos/metabolismo , Células Imobilizadas , Cinética
18.
Sci Rep ; 9(1): 2532, 2019 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-30796348

RESUMO

Structural hydrological connectivity has been proposed to describe the geological structure of the landscape as well as to explain hydrological behaviors. Indices based on the topological or soil condition were developed to interpret their relationships. While previous studies mainly focused on well-instrumented catchments which are narrow in humidity or temperate zone, the hydrological responses to structural connectivity at the plot and hill slope scale as well as in arid or semi-arid climate conditions remain unclear. This study was conducted in the semi-arid mountainous region of northern China in Haihe Basin which is the source of water of about 350 million people. Experiments were conducted during the rainy season in 2012 and 2013 using four runoff plots. Two indices, flow path length (FL) based on topography and integral connectivity scale length (ICSL) based on soil moisture conditions, developed to represent hydrological connectivity structure and the runoff response to rainfall were analyzed. The results showed that the surface runoff coefficient was strongly and positively linearly correlated to FL, and the correlation between subsurface flow and ICSLs was quadratic. Plots with shorter FL required more rainfall to generate surface runoff. In the shallow soil layer, when the ICSLs are relatively low, the soil can store more water and less rainfall feeds subsurface runoff. Further analysis indicated that improved shallow soil connectivity conditions might enhance the water-holding capacity and lead to lower water yields for each event. This study demonstrated that hydrological structure connectivity could explain the mechanism of runoff generation in semi-arid areas while further experiments should be undertaken to find the threshold-like relationship between FL and surface runoff as well as the influence of plant cover on hydrological behaviors.

19.
Plant Physiol ; 179(3): 1080-1092, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30659067

RESUMO

Ovule development is critical for seed development and plant reproduction. Multiple transcription factors (TFs) have been reported to mediate ovule development. However, it is not clear which intracellular components regulate these TFs during ovule development. After their synthesis, TFs are transported into the nucleus a process regulated by karyopherins commonly known as importin alpha and ß. Around half of Arabidopsis (Arabidopsis thaliana) importin ß-coding genes have been functionally characterized but only two with specific cargos have been identified. We report here that Arabidopsis IMPORTIN ß4 (IMB4) regulates ovule development through nucleocytoplasmic transport of transcriptional coactivator growth regulating factors-interacting factors (GIFs). Mutations in IMB4 impaired ovule development by affecting integument growth. imb4 mutants were also defective in embryo sac development, leading to partial female sterility. IMB4 directly interacts with GIFs and is critical for the nucleocytoplasmic transport of GIF1. Finally, functional loss of GIFs resulted in ovule defects similar to those in imb4 mutants, whereas enhanced expression of GIF1 partially restored the fertility of imb4 The results presented here uncover a novel genetic pathway regulating ovule development and reveal the upstream regulator of GIFs.


Assuntos
Proteínas de Arabidopsis/fisiologia , Arabidopsis/metabolismo , Transporte Ativo do Núcleo Celular , Arabidopsis/genética , Arabidopsis/crescimento & desenvolvimento , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Núcleo Celular/metabolismo , Citocininas/metabolismo , Citoplasma/metabolismo , Ácidos Indolacéticos/metabolismo , Óvulo Vegetal/genética , Óvulo Vegetal/crescimento & desenvolvimento , Óvulo Vegetal/metabolismo , Transativadores/metabolismo
20.
Global Health ; 15(1): 9, 2019 01 25.
Artigo em Inglês | MEDLINE | ID: mdl-30683119

RESUMO

BACKGROUND: China, which used to be an export country for migrants, has become a new destination for international migrants due to its rapid economic growth. However, little empirical data is available on the health status of and health service access barriers faced by these international migrants. METHODS: Foreigners who visited the Guangzhou Municipal Exit-Entry Administration Office to extend their visas were invited to participate in the study. Quantitative data were collected using electronic questionnaire in 13 languages. The participants were characterised by the income level of their country of origin (high-, middle- and low-income countries (HICs, MICs and LICs, respectively)), and the key factors associated with their health status, medical insurance coverage and perceptions of health services in China were examined. RESULTS: Overall, 1146 participants from 119 countries participated in the study, 57.1, 25.1 and 17.8% of whom were from MICs, HICs and LICs, respectively. Over one fifth of the participants experienced health problems while staying in China, and about half had no health insurance. Although the participants from HICs were more likely than those from MICs and LICs to have medical insurance, they were also more likely to have health problems. Furthermore, 43.0, 45.0 and 12.0% of the participants thought that the health services in China were good, fair and poor, respectively. Among the participants, those from HICs were less likely to have positive feedback. CONCLUSIONS: Our study is the first to report a quantitative survey of the health status, health insurance coverage, and health service perceptions of a diverse and surging population of international migrants in China. The findings call for more in-depth studies on the challenges presented by the increasing global migration to the health system.


Assuntos
Atitude Frente a Saúde , Nível de Saúde , Migrantes/psicologia , Migrantes/estatística & dados numéricos , Adulto , China , Países Desenvolvidos/estatística & dados numéricos , Países em Desenvolvimento/estatística & dados numéricos , Feminino , Humanos , Seguro Saúde/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
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