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Front Neurol ; 10: 1099, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31681158


The Willis covered stent (WCS) may prolapse into the aneurysmal sac due to device migration or foreshortening. We present a useful salvage strategy that can reorient a prolapsed WCS into a more suitable alignment. An intra-procedural prolapse of a WCS into a large cavernous aneurysm occurred in a 70-year-old female patient. A pipeline embolization device (PED) was used to retrieve the WCS and successfully accomplish flow diversion. Maintaining proximal access and ensuring that the microwire is securely held within the central axis of the herniated stent are critical until the entire parent vessel can be reconstructed. This salvage technique may help to regain proximal access and reposition the flow diversion constructs following WCS prolapse.

Onco Targets Ther ; 9: 3783-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27382314


BACKGROUND: The purpose of this study was to retrospectively evaluate the therapeutic efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) combined with synchronous transcatheter arterial chemoembolization (TACE) in patients with colorectal liver metastases (CRLM). PATIENTS AND METHODS: A retrospective analysis was performed in 30 patients who were treated with ultrasound-guided percutaneous MWA combined with synchronous TACE for colorectal cancer liver metastases from November 2011 to December 2014 in Zhongshan Hospital, Fudan University. The response of the tumor to treatment was evaluated by follow-up computed tomography and/or magnetic resonance imaging. Local tumor control, procedure-related complications, and long-term survival data were analyzed. RESULTS: A total of 30 patients with 43 tumors ranging in size from 1.4 cm to 10.0 cm were analyzed. The patients' mean age was 61.6±10.3 years (range, 44.0-78.0 years). The median follow-up time was 26.5±10.4 months (range, 13.3-50.6 months). The complete ablation rate was 81.4% (35/43 lesions) for CRLM. Complete response was achieved in eight cases (26.7%), and partial response was achieved in 17 cases (56.7%) 1 month after the procedure. The objective response rate (complete response + partial response) was 83.4%. Progression-free survival and overall survival were 5.0 months and 11.0 months, respectively. The 12-month and 24-month survival rates were 46.7% and 25.4%, respectively. A total of 22 patients succumbed during follow-up due to tumor progression. No major complications or perioperative mortalities were recorded. CONCLUSION: Ultrasound-guided percutaneous MWA combined with synchronous TACE therapy is a safe and effective modality for patients with CRLM.

Yao Xue Xue Bao ; 46(8): 946-50, 2011 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-22007520


To study the chemical constituents of Bauhinia glauca subsp. pernervosa, eleven phenolic acids were isolated from a 95% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, MCI, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including 1H NMR, 13C NMR, 2D NMR, and HR-ESI-MS, these compounds were identified as isopropyl O-beta-(6'-O-galloyl)-glucopyranoside (1), ethyl O-beta-(6'-O-galloyl)-glucopyranoside (2), 3, 4, 5-trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside (3), 3, 4, 5-trimethoxyphenyl-beta-D-glucopyranoside (4), gallic acid (5), methyl gallate (6), ethyl gallate (7), protocatechuic acid (8), 3, 5-dimethoxy-4-hydroxybenzoic acid (9), erigeside C (10) and glucosyringic acid (11). Among them, compound 1 is a new polyhydroxyl compound; compounds 2, 10, and 11 were isolated from the genus Bauhinia for the first time, and the other compounds were isolated from the plant for the first time. Compounds 6 and 8 showed significant protein tyrosine phosphatase1B (PTP1B) inhibitory activity in vitro with the IC50 values of 72.3 and 54.1 micromol x L(-1), respectively.

Bauhinia/química , Ácido Gálico/análogos & derivados , Glucosídeos/isolamento & purificação , Hidroxibenzoatos/isolamento & purificação , Plantas Medicinais/química , Benzoatos/química , Benzoatos/isolamento & purificação , Benzoatos/farmacologia , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Ácido Gálico/química , Ácido Gálico/isolamento & purificação , Ácido Gálico/farmacologia , Glucosídeos/química , Glucosídeos/farmacologia , Hidroxibenzoatos/química , Hidroxibenzoatos/farmacologia , Fenóis/química , Fenóis/isolamento & purificação , Fenóis/farmacologia , Caules de Planta/química , Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo
Chem Pharm Bull (Tokyo) ; 57(6): 628-31, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19483349


Seven flavonoids were isolated from Bauhinia glauca subsp. pernervosa, and their structures were elucidated as 6-methyl homoeriodictyol (1), bauhiniaside A (2), bauhiniasin (3), 2',4'-dihydroxy-4-methoxydihydrochalcone-4'-O-beta-D-glucopyranoside (4), farrerol (5), homoeriodictyol (6), and 2',4'-dihydroxy-4-methoxydihydrochalcone (7) on the basis of spectroscopic analysis. Compounds 1, 2 and 3 are new flavonoids, compound 4 is a new natural product, its NMR data is reported for the first time. Compounds 5 and 7 were isolated from the genus Bauhinia for the first time, and compound 6 was isolated from the plant for the first time.

Bauhinia/química , Flavonoides/química , Cromatografia em Camada Delgada , Flavonoides/isolamento & purificação , Hidrólise , Espectroscopia de Ressonância Magnética , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta