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1.
Org Biomol Chem ; 20(43): 8501-8505, 2022 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-36268850

RESUMO

The first example of the electrocatalytic multicomponent synthesis of 4-chloro/bromo/iodopyrazoles from hydrazines, acetylacetones and sodium halides under chemical oxidant- and external electrolyte-free conditions has been developed. Sodium halides played a dual role as a halogenation reagent and a supporting electrolyte. Mechanism studies revealed that the bromination reaction proceeded via an ionic pathway, whereas both chlorination and iodination proceeded via a radical pathway.


Assuntos
Halogênios , Sódio , Halogenação , Oxidantes , Íons
2.
Ultrason Sonochem ; 90: 106181, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36182836

RESUMO

Spherical SiO2 nanoparticles (SSNs) have been inventively synthesized using the Stöber method with sonication at medium-high frequencies (80, 120, and 500 kHz), aiming to control SSN size and shorten reaction time. Compared to the conventional method, such sonication allowed the Stöber reaction complete in 20-60 min with a low molar ratio of NH4OH/tetraethyl orthosilicate (0.84). The hydrodynamic diameters of 63-117 nm of SSNs were obtained under sonication with 80, 120, and 500 kHz of ultrasonic frequencies. Moreover, the SSNs obtained were smaller at 120 kHz than at 80 kHz in a multi-frequencies ultrasonic reactor, and the SSN size decreased with increasing ultrasonic power at 20 °C, designating the sonochemical unique character, namely, the SSN-size control is associated with the number of microbubbles originated by sonication. With another 500 kHz ultrasonic bath, the optimal system temperature for producing smaller SSNs was proven to be 20 °C. Also, the SSN size decreased with increasing ultrasonic power. The smallest SSNs (63 nm, hydrodynamic diameter by QELS, or 21 nm by FESEM) were obtained by sonication at 207 W for 20 min at 20 °C. Furthermore, the SSN size increased slightly with increasing sonication time and volume, favoring the scale-up of SSNs preparation. The mechanisms of controlling the SSN size were further discussed by the radical's role and effects of ammonia and ethanol concentration.


Assuntos
Nanopartículas , Sonicação , Sonicação/métodos , Dióxido de Silício , Microbolhas , Temperatura
3.
Transl Cancer Res ; 11(8): 2946-2952, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36093539

RESUMO

Background: There is a high risk of hypoxia or apnea for patients with huge tracheal tumor during general anesthesia. Here we reported two cases of extremely huge endotracheal tumors undergoing fiberoptic bronchoscopic interventional therapy under general anesthesia. We hope the experience will be of reference value for formulating reasonable anesthesia scheme for such critically ill patients. Case Description: The two patients were accompanied with severe respiratory distress. And fiberoptic bronchoscopy revealed that the trachea cavity was blocked nearly completely by extremely huge tracheal tumor. Tracheal tumors were scheduled to be removed with fiberoptic bronchoscopic interventional therapy. General anesthesia was inducted with alfentanil and propofol. Then a laryngeal mask was inserted and spontaneous breath was preserved. During the operation, complete airway obstruction occurred, but it was effectively handled by using the fiberoptic bronchoscope to push the tumor and reopen the gap between the mass and the tracheal wall. After the therapy, the patients' symptom of respiratory distress was relieved significantly. Conclusions: For patients with huge tracheal tumor that to be handled with fiberoptic bronchoscopic interventional therapy, general anesthesia with spontaneous breath induced by alfentanil and propofol is preferable. The most important, when complete airway blockade occurs during the process, pushing the tumor and reopening the respiratory tract with fiberoptic bronchoscope is a fairly effective solution to enable patients to be reoxygenated.

4.
Front Pharmacol ; 13: 949754, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36120296

RESUMO

Mechanisms contributing to the pathogenesis of myocardial ischemia-reperfusion (I/R) injury are complex and multifactorial. Many strategies have been developed to ameliorate myocardial I/R injuries based on these mechanisms. However, the cardioprotective effects of these strategies appear to diminish in diabetic states. Diabetes weakens myocardial responses to therapies by disrupting intracellular signaling pathways which may be responsible for enhancing cellular resistance to damage. Intriguingly, it was found that Dexmedetomidine (DEX), a potent and selective α2-adrenergic agonist, appears to have the property to reverse diabetes-related inhibition of most intervention-mediated myocardial protection and exert a protective effect. Several mechanisms were revealed to be involved in DEX's protection in diabetic rodent myocardial I/R models, including PI3K/Akt and associated GSK-3ß pathway stimulation, endoplasmic reticulum stress (ERS) alleviation, and apoptosis inhibition. In addition, DEX could attenuate diabetic myocardial I/R injury by up-regulating autophagy, reducing ROS production, and inhibiting the inflammatory response through HMGB1 pathways. The regulation of autonomic nervous function also appeared to be involved in the protective mechanisms of DEX. In the present review, the evidence and underlying mechanisms of DEX in ameliorating myocardial I/R injury in diabetes are summarized, and the potential of DEX for the treatment/prevention of myocardial I/R injury in diabetic patients is discussed.

5.
Front Neurosci ; 16: 920731, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35911988

RESUMO

Background: The long-term outcomes of acute large vessel occlusion (LVO) in anterior circulation treated by endovascular treatment (EVT) remains to be determined. The aim of this study was to assess the 5-year outcomes of patients with LVO who underwent EVT. Methods: This study was an observational, nationwide registry of consecutive patients with acute LVO who received EVT in 28 comprehensive stroke centers in China. The primary outcome was the proportion of favorable outcome [modified Rankin Scale score (mRS) 0-2] at 5 years. Secondary outcomes included proportions of patients with excellent outcome (mRS 0-1), all-cause mortality and risk of stroke recurrence at 5 years. Results: A total of 807 patients were included into the study and had 90-day follow-up data, 657 patients had 5-year follow-up data. At 90 days, 218 patients (27.0%) had an excellent outcome, 349 patients (43.2%) had a favorable functional outcome. 199 patients (24.7%) died. At 5 years, 190 patients (28.9%) had an excellent outcome, 261 patients (39.7%) had a favorable functional outcome, 317 patients (48.2%) died and 129 (28.2%) had stroke recurrence. Because of missing 5-year follow-up data, among available 269 patients who achieved functional independence at 90 days, 208 (77.3%) maintained favorable outcome, 19 (7.1%) had disability (mRS 3-5) and 42 (15.6%) died at 5 years. Furthermore, among available 189 patients with mRS 3-5 at 90 days, 53 (28.0%) patients achieved favorable functional outcome, 60 (31.7%) patients maintained unfavorable functional outcome and 76 (40.2%) patients died within 5 years. Multivariate analyses identified that younger age [odds ratio (OR): 0.96; 95% CI, 0.93-0.99; P = 0.009], lower mRS at 90 days (OR: 0.15; 95% CI, 0.10-0.23; P < 0.001) and absence of stroke recurrence (OR: 0.001; 95% CI, 0.000-0.006; P < 0.001) were significantly associated with favorable outcome at 5 years. Advanced age (OR: 1.06, 95% CI, 1.04-1.08; P < 0.001), higher mRS at 90 days (OR: 0.84; 95% CI, 0.73-0.98; P = 0.021) and atrial fibrillation (OR: 1.63; 95% CI, 1.02-2.60; P = 0.04) were independent factors for stroke recurrence. Conclusion: Our results indicated that the beneficial effect of EVT in patients with acute LVO can be sustained during the course of at least 5 years. Reducing the risk of stroke recurrence by anticoagulation for atrial fibrillation may be a crucial strategy to improve long-term outcome.

6.
J Hazard Mater ; 440: 129642, 2022 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-35961077

RESUMO

Antibiotics (ABX) residues occur frequently in milk, causing considerable wastage of medicated milk and serious economic losses, and making the issue a burden for the dairy industry. Improper disposal of medicated milk harms dairy production, animal welfare, and the environment. This work studies the use of ozonation in a vortex reactor for removing ceftiofur hydrochloride (CEF), sulfamonomethoxine sodium (SMM), marbofloxacin (MAR) and oxytetracycline (OTC) from milk. In terms of residual concentration, O3 efficiency and the degradation kinetics of the various O3-involving processes in the vortex reactor, ABX removal via ozonation is better using stronger vortexing, which induces hydrodynamic cavitation. CEF undergoes the fastest degradation, followed by SMM, MAR, and OTC. High ABX hydrophobicity favors ABX degradation via ozonation, O3/H2O2, and O3/Na2S2O8. ABX oxidation by •OH at the O3 gas-bubble/milk interface is the principle degradation pathway, except for MAR. ABX degradation follows pseudo-first-order kinetics and is affected by initial ABX concentration, O3 concentration/flow rate, reaction temperature, and milk components to varying degrees. Under optimal ozonation conditions, ABX residues meet the maximum limits as set by the European Commission and no antimicrobial activity was observed. The decontaminated milk was therefore suggested to be reused as calf food, animal feed, organic fertilizer, etc.


Assuntos
Oxitetraciclina , Ozônio , Sulfamonometoxina , Poluentes Químicos da Água , Purificação da Água , Animais , Antibacterianos , Fertilizantes , Peróxido de Hidrogênio/química , Leite/química , Oxirredução , Ozônio/química , Sódio , Poluentes Químicos da Água/química
7.
Front Plant Sci ; 13: 903936, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35812947

RESUMO

Melatonin (MT) is a ubiquitous hormone molecule that is commonly distributed in nature. MT not only plays an important role in animals and humans but also has extensive functions in plants. Selenium (Se) is an essential micronutrient for animals and humans, and is a beneficial element in higher plants at low concentrations. Postharvest diseases caused by fungal pathogens lead to huge economic losses worldwide. In this study, tomato fruits were treated with an optimal sodium selenite (20 mg/L) and melatonin (10 µmol/L) 2 h and were stored for 7 days at room temperature simulating shelf life, and the synergistic effects of Se and MT collectively called Se-Mel on gray mold decay in tomato fruits by Botrytis cinerea was investigated. MT did not have antifungal activity against B. cinerea in vitro, while Se significantly inhibited gray mold development caused by B. cinerea in tomatoes. However, the interaction of MT and Se showed significant inhibition of the spread and growth of the disease, showing the highest control effect of 74.05%. The combination of MT with Se treatment enhanced the disease resistance of fruits by improving the activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), as well as increasing the gene expression level of pathogenesis-related (PR) proteins. Altogether, our results indicate that the combination of MT and Se would induce the activation of antioxidant enzymes and increase the expression of PR proteins genes that might directly enhance the resistance in tomato fruit against postharvest pathogenic fungus B. cinerea.

8.
Materials (Basel) ; 15(6)2022 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-35329647

RESUMO

This work aims to investigate and analyse the mechanism of rock failure under high-voltage electropulses in order to evaluate and increase the efficiency of high-voltage pulse technology in geological well drilling, tunnel boring, and other geotechnical engineering applications. To this end, this paper discusses the equivalent circuit of electric pulse rock breaking, the model of shock wave in electro channel plasma, and, particularly, the model of rock failure in order to disclose the rock failure process when exposed to high-voltage electropulse. This article uses granite as an example to present an analytical approach for predicting the mechanical behaviour of high-voltage electropulses and to analyse the damage that occurs. A numerical model based on equivalent circuit, shock wave model, and elasto-brittle failure criterion is developed for granite under electropulse to further examine the granite failure process. Under the conditions described in this study, and using granite as an example, the granite is impacted by a discharge device (Marx generator) with an initial voltage U0 that is 10 kV and a capacitance F that is 5 µF before it begins to degrade at about 40 µs after discharge, with the current reaching its peak at approximately 50 µs. The shock wave pressure then attains a peak at about 70 µs. Dense short cracks form around granite and the dominant cracks grow to an average length of about 20 cm at around 200 µs. The crack width dcr is predicted to be approximately 1.6 mm. This study detects dense cracks in a few centimetres surrounding the borehole, while around seven dominant cracks expand outward. The distribution of the length of the dominating cracks can be inhomogeneous because of the spatial heterogeneity of granite's tensile strength, however the heterogeneity has an insignificant effect on the crack growth rate, total cracked area, or the number of main cracks. The mechanism of rock failure under electropulse can be well supported by the findings of numerical simulations and analytical studies.

9.
Materials (Basel) ; 15(6)2022 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-35329691

RESUMO

A semi-analytical solution for forecasting the soil behavior induced by lightning strikes is of great engineering significance to calculate the radius of the soil plastic zone. In this paper, a simplified two-stage method is employed to solve the shock wave pressure and the radius of the soil plastic zone. The solution is verified against experimental data. Using the present model, the major factors dominating the shock wave pressure and the radius of the soil plastic zone are investigated. The results show that (1) the radius of the soil plastic zone (rp) induced by lightning decreases monotonically with cohesion (c) and internal friction angle (φ), while c has a better effect on soil properties than φ does; (2) increasing the initial radius of the plasma channel (ri0) can reduce the pressure (P) and increasing ri0 has a nonnegligible effect on rp; with ri0 increasing by 100%, the radius of the soil plastic zone increases by 47.9-59.7%; (3) the plasma channel length (L) has a significant influence on P and rp, especially when L is at a relatively low level; (4) the rp induced by lightning decreases exponentially with attenuation coefficient (a); (5) the wavefront time is a major factor while the half-value time is a minor factor for the shock wave pressure induced by plasma explosives.

10.
Food Chem ; 385: 132695, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35338997

RESUMO

CPAC-SPE-HPLC (coconut powdered activated carbon -SPE- HPLC) has been developed for the determination of antibiotic (ABX), sulfamonomethoxine sodium (SMM), oxytetracycline (OTC), ceftiofur hydrochloride (CEF) and marbofloxacin (MAR), in water and milk. Over 99.0% SMM and OTC were recovered from 20 mL of 0.5 µg/mL ABX solution using 10 mg-CPAC for adsorption and 2 mL of 30% NH4OH/EtOH (1/19 v/v) for elution. Similarly, over 99.0% CEF and MAR were recovered using 15 mg-CPAC and 2 mL of 30% NH4OH/n-PrOH (1/19 v/v). Moreover, the recovery efficiencies of various ABX from 5 to 80 mL of 0.02-2.00 µg/mL medicated milk containing 10 mM EDTA are ordered as follows: OTC (99.3%), SMM (99.1%) > CEF (68.9%) > MAR (61.4%). No interference towards HPLC analysis were observed with elution using 2 mL of 30% NH4OH/EtOH (1/19 v/v). Furthermore, much lower limit of detections (0.02 µg/mL) than the maximum residual limits from European Commission (0.075-0.100 µg/mL) were obtained.


Assuntos
Leite , Oxitetraciclina , Animais , Antibacterianos/análise , Carvão Vegetal , Cromatografia Líquida de Alta Pressão , Leite/química , Oxitetraciclina/análise , Extração em Fase Sólida , Água
11.
J Clin Pharmacol ; 62(8): 935-947, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35220587

RESUMO

Dexmedetomidine has been identified as a useful adjunct to improve the effect of nerve blocks in adults; however, its effect for children has not yet been fully investigated. This meta-analysis aimed to evaluate the reliability and efficacy of dexmedetomidine as a local anesthetic adjunct for pediatric surgeries. Eligible studies were searched in Cochrane, Embase, PubMed, and CBM. RevMan 5.4 was used to assess the risk of bias of each study and perform statistical analysis. Stata 15.0 was used to evaluate the publication bias of primary outcomes. Thirteen randomized controlled trial (RCTs) involving 722 patients aged 6 months to 12 years were harvested. Statistical analysis showed that dexmedetomidine resulted in: a significantly longer duration of analgesia (standardized mean difference [SMD], 7.16; 95% confidence interval [95%CI], 4.88 to 9.43; P < .001; I2  = 98%); a reduction in the 1-hour pain score (mean difference [MD], -0.27; 95%CI, -0.47 to -0.06; P = .01; I2  = 28%); cumulative doses of rescue analgesic required of 2 doses (risk ratio [RR], 0.26; 95%CI, 0.14 to 0.49; P < .001; I2  = 0) or 3 doses (RR, 0.04; 95%CI, 0.01 to 0.16; P < .001; I2  = 4%); the frequency of emergence agitation (RR, 0.44; 95%CI, 0.22 to 0.91; P = .03; I2  = 0); and a reduction in the onset time of blocks (mean difference -3.56; 95%CI, -6.39 to -0.74; P = .01; I2  = 90%). However, the incidence of some side effects, including hypotension, bradycardia, nausea and vomiting, pruritis, urinary retention, and respiratory depression, did not significantly differ between the dexmedetomidine group and the placebo group. Therefore, dexmedetomidine is a reliable and efficient adjunct to local anesthetics in children.


Assuntos
Anestésicos Locais , Dexmedetomidina , Adjuvantes Anestésicos , Adulto , Anestésicos Locais/efeitos adversos , Criança , Dexmedetomidina/efeitos adversos , Humanos , Dor Pós-Operatória/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Reprodutibilidade dos Testes
12.
Arch Gynecol Obstet ; 306(1): 7-15, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-34648063

RESUMO

PURPOSE: To investigate the effects of different anesthesia methods on maternal and neonatal outcomes in pregnant patients with pulmonary arterial hypertension (PAH). METHODS: We searched PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang and QVIP for investigating the effects of general anesthesia (GA) and local anesthesia (LA) in pregnant patients with PAH. Results were expressed as weighted mean difference (WMD) or risk ratio (RR) with 95% confidence intervals (CIs). Publication bias was assessed by the Begg's test. RESULTS: Totally, 18 articles containing 628 LA and 481 GA patients were involved in our study. The postoperative blood oxygen saturation (WMD = - 4.040, 95%CI: - 5.505 to - 2.576) and maternal mortality rate (RR = 0.507, 95%CI: 0.300-0.858) were lower in LA group than those in GA group. The postoperative systolic blood pressure (WMD = 15.647, 95%CI: 13.294-18.000) and postoperative diastolic blood pressure (WMD = 6.758, 95%CI: 5.715-7.802) were high in LA group compared with those in GA group. The mechanical ventilation time (WMD = - 4.112, 95%CI: - 4.655 to - 3.569), ICU admission time (WMD = - 4.176, 95%CI: - 4.523 to - 3.828), length of stay (WMD = -7.289, 95%CI: -7.799-6.779) were shorter in LA group than those in GA group. All P values were < 0.05. CONCLUSIONS: LA is superior to GA in regards to the postoperative blood oxygen saturation, the postoperative systolic blood pressure, postoperative diastolic blood pressure, the mechanical ventilation time, ICU admission time, length of stay and the maternal mortality rate. REGISTRATION NUMBER: osf.io/juybq ( https://osf.io/search/ ).


Assuntos
Hipertensão Arterial Pulmonar , Anestesia Geral/efeitos adversos , Anestesia Local , Pressão Sanguínea , Feminino , Humanos , Recém-Nascido , Período Pós-Operatório , Gravidez
13.
J Hazard Mater ; 426: 128061, 2022 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-34953260

RESUMO

The detection of air pollutant nitrogen dioxide (NO2) is of great importance arising from its great harm to the ecological environment and human health. However, the detection range of most NO2 sensors is ppm-level, and it is still challenging to achieve lower concentration (ppb-level) NO2 detection. Herein, 2D tin diselenide nanoflakes decorated with 1D zinc oxide nanowires (SnSe2/ZnO) heterojunctions were first reported by facile hydrothermal and ultra-sonication methods. The response of the fabricated SnSe2/ZnO sensor enhances 3.41 times on average compared with that of pure SnSe2 sensor to 50-150 ppb NO2 with a high detection sensitivity (22.57 ppm-1) at room temperature. In addition, the SnSe2/ZnO sensor has complete recovery, negligible cross-sensitivity, and small relative standard deviation (6.98%) during the 1 month sensing test, which can meet the requirements for NO2 detection in environmental monitoring. The enhanced NO2 sensing performance can be attributed to the n-n heterojunction constructed between SnSe2 and ZnO. The as-prepared sensor based on SnSe2/ZnO hybrid significantly promotes the development of the low detection limit of the NO2 sensor at room temperature.


Assuntos
Nanofios , Óxido de Zinco , Humanos , Limite de Detecção , Dióxido de Nitrogênio , Temperatura
14.
Immun Ageing ; 18(1): 42, 2021 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-34740366

RESUMO

BACKGROUND: Toll-like receptor 4 (TLR4) is a pattern recognition receptor of the innate immune system. TLR4 contributes to many aging-related chronic diseases. However, whether TLR4 is involved in cardiovascular injury during the aging process has not been investigated. METHODS: The effects of TLR4 on the cardiovascular system of aged mice were investigated in TLR4-/- mice. An intraperitoneal glucose tolerance test (IPGTT) and insulin sensitivity test (IST) were conducted to evaluate global insulin sensitivity. Echocardiography was used to measure cardiac structure and performance. An isolated artery ring assay was used to measure the vasodilator function of the thoracic aorta. The inflammatory response was reflected by the serum concentration of cytokines. RESULTS: TLR4 expression increased in the hearts and aortas of mice in an age-dependent manner. Loss of TLR4 increased insulin sensitivity in aged mice. Moreover, loss of TLR4 improved cardiac performance and endothelium-dependent vascular relaxation in aged mice. Importantly, the increases in serum inflammatory cytokines and oxidative stress in the heart and aorta were also inhibited by TLR4 deficiency. CONCLUSION: In summary, loss of TLR4 improved cardiac performance and endothelium-dependent vascular relaxation in aged mice. The reduced inflammatory responses and oxidative stress may be the reason for the protective effects of TLR4 deficiency during aging. Our study indicates that targeting TLR4 is a potential therapeutic strategy for preventing aging-related cardiovascular disease.

15.
Forensic Sci Int ; 329: 111051, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34688187

RESUMO

Due to their limited penetration power, expansion bullets are known for their good effectiveness and less endangerment to bystanders, thereby playing an important role in the fight against terrorism and violence. This study considered 20 bullet configurations with different shape parameters influencing the motion and deformation of 9 mm expansion bullets in gelatine. Owing to the constraints of high-speed photography, experimental observations have limitations. However, through numerical simulation, this study found that the penetration process of the 9 mm expansion bullets through biological tissues, as represented by the gelatine block in this study, can be subdivided into four stages. Further, the expansion bullet is highly sensitive to the impact velocity, and did not completely expand when travelling at speeds below the critical velocity and over-expanded when travelling at speeds above the threshold velocity. The results of this study revealed the interaction mechanism between expansion bullets and gelatine, which are significant to ballistic wounding assessment and treatment of expansion bullets.

16.
Pharmgenomics Pers Med ; 14: 971-976, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34413668

RESUMO

BACKGROUND: The causal relationship between insomnia and migraine is contradictory and no study has been carried out among the Chinese population to date. METHODS: In this case, we conducted a case-control study and a bidirectional mendelian randomization (MR) analysis to determine whether insomnia is causally related to the development of migraine. The instrumental variables for insomnia were derived from the largest genome-wide association study of 1,331,010 participants, while the genetic instruments for migraine were available from the largest meta-analysis of migraine with 59,674 cases and 316,078 controls. RESULTS: In case-control study, subjects with insomnia have significantly higher risk of migraine (OR=4.29, 95% CI: 3.21-5.74, P<0.001), compared with those without insomnia. The bidirectional two-sample MR analysis revealed that insomnia was significantly associated with higher risk of migraine (OR=1.24, 95% CI: 1.11-1.38, P=1.01×10-4), and the results were validated in the UK Biobank data. The results showed no indication for directional pleiotropy effects as assessed by the MR-Egger intercept (P>0.05). CONCLUSION: Conclusively, our study highlighted that increased migraine risk was confined to subjects with a genetic pre-disposition to insomnia, and these findings had potential implications for improving the sleep quality to reduce the burden of migraine.

17.
ACS Appl Mater Interfaces ; 13(23): 27188-27199, 2021 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-34096254

RESUMO

Humidity sensors with good repeatability, low hysteresis, and low-power consumption are increasingly important for environmental monitoring and industrial control applications. Herein, an impedance-type humidity sensor under low working voltage (5 mV) utilizing a rGO-BiVO4 nanocomposite is demonstrated. The rGO-BiVO4 humidity sensor exhibits superior sensing performances, including good repeatability, negligible hysteresis (0.47%), fast response and recovery time, low power consumption, good stability, and anti-interference ability. The ultraviolet-visible absorption spectrum reveals that the narrow band gap of the rGO-BiVO4 nanocomposite is conductive to the electron transfer. The complex impedance spectra and the energy band structure analysis further suggest that the boosted humidity performance results from the formation of a heterojunction and the decrease of the heterojunction barrier height. The facile fabrication route, enhanced sensing performance, and excellent device reliability make the rGO-BiVO4 sensor highly attractive for high-end humidity sensing applications.

18.
Ultrason Sonochem ; 74: 105566, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33975189

RESUMO

Antibiotic residues in water are general health and environmental risks due to the antibiotic-resistance phenomenon. Sonication has been included among the advanced oxidation processes (AOPs) used to remove recalcitrant contaminants in aquatic environments. Sonochemical processes have shown substantial advantages, including cleanliness, safety, energy savings and either negligible or no secondary pollution. This review provides a wide overview of the different protocols and degradation mechanisms for antibiotics that either use sonication alone or in hybrid processes, such as sonication with catalysts, Fenton and Fenton-like processes, photolysis, ozonation, etc.


Assuntos
Antibacterianos/química , Sonicação , Água/química , Antibacterianos/isolamento & purificação , Soluções , Poluentes Químicos da Água/química , Poluentes Químicos da Água/isolamento & purificação
19.
Int J Geriatr Psychiatry ; 36(10): 1514-1523, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33899959

RESUMO

BACKGROUND: Both the quality of sleep and depression impact short-term memory (STM) while they influence each other. However, the underlying mechanisms are not yet clear. Herein, we aimed to explore the mediating effect of depression between sleep quality and STM in older adults and further test the gender differences in this relationship. METHODS: A cluster sampling survey was carried out among 903 residents that were aged 60+ years in a semi-closed island of Xiamen, China, in 2019. The subjects' sleep quality and depression were measured using the Pittsburgh Sleep Quality Index (PSQI) and the 15-item Geriatric Depression Scale (GDS-15), respectively. The three-item recall test was utilized to measure STM function. Mediation analyses were performed using the structural equation model and bias-corrected bootstrap method. Next, the Wald-test was utilized to determine gender differences in the pathway. RESULTS: Overall, 355 men and 508 women, with a mean age of 69.55 and 70.97, respectively, had valid data on the main variables. Depression was found to mediate the effect of sleep quality on STM (a*b = -0.076, p < 0.05). Interestingly, while this indirect effect existed in the female group (af *bf  = -0.126, p < 0.05), it did not in the male group (am *bm  = 0.017, p = 0.677). The Wald-test indicated no gender differences in the pathway from sleep quality to depression (p = 0.303). However, the pathway from depression to STM function was found to be significantly stronger for females than males (p = 0.0198). CONCLUSION: Higher sleep quality was found to be associated with improved STM function. Furthermore, the association was found to be regulate indirectly by lower depressive symptoms for females, but directly for males. Therefore, appropriate psychological interventions may be beneficial to the maintenance of STM for older adults, particularly for women.


Assuntos
Depressão , Memória de Curto Prazo , Idoso , China/epidemiologia , Depressão/epidemiologia , Feminino , Humanos , Masculino , Sono , Inquéritos e Questionários
20.
BMJ Open ; 11(4): e043415, 2021 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-33795300

RESUMO

OBJECTIVES: We aimed to determine predictors of mortality within 90 days and develop a simple score for patients with mechanical thrombectomy (MT). DESIGN: Analysis of a multicentre prospective registry. SETTING: In six participating centres, patients who had an acute ischaemic stroke (AIS) treated by MT between March 2017 and May 2018 were documented prospectively. PARTICIPANTS: 224 patients with AIS were treated by MT. RESULTS: Of 224 patients, 49 (21.9%) patients died, and 87 (38.8%) were independent. Variables associated with 90-day mortality were age, previous stroke, admission National Institutes of Health Stroke Scale (NIHSS), fasting blood glucose and occlusion site. Logistic regression identified four variables independently associated with 90-day mortality: age ≥80 years (OR 3.26, 95% CI 1.45 to 7.33), previous stroke (OR 2.33, 95% CI 1.04 to 5.21), admission NIHSS ≥18 (OR 2.37, 95% CI 1.13 to 4.99) and internal carotid artery or basilar artery occlusion (OR 2.92, 95% CI 1.34 to 6.40). Using these data, we developed predicting 90-day mortality of AIS with MT (PRACTICE) score ranging from 0 to 6 points. The receiver operator curve analysis found that PRACTICE score (area under the curve (AUC)=0.744, 95% CI 0.669 to 0.820) was numerically better than iScore (AUC=0.661, 95% CI 0.577 to 0.745) and Predicting Early Mortality of Ischemic Stroke score (AUC=0.638, 95% CI 0.551 to 0.725) for predicting 90-day mortality. CONCLUSIONS: We developed a simple score to estimate the 90-day mortality of patients who had an AIS treated with MT. But the score needs to be prospectively validated. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry (ChiCTR-OOC-17013052).


Assuntos
Isquemia Encefálica , AVC Isquêmico , Acidente Vascular Cerebral , Idoso de 80 Anos ou mais , Isquemia Encefálica/terapia , Humanos , Sistema de Registros , Estudos Retrospectivos , Acidente Vascular Cerebral/terapia , Trombectomia , Resultado do Tratamento
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