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1.
Mater Sci Eng C Mater Biol Appl ; 109: 110615, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32228941

RESUMO

Four nanostructured MnO2 with various controllable morphologies, including nanowires, nanorods, nanotubes and nanoflowers were synthesized, and then further composited with nitrogen-doped graphene (NG) with the assistance of ultrasonication. The surface morphologies, phase structures, and electrochemical performances of the proposed MnO2/NG nanohybrids were investigated by various techniques, and their catalytic activities on the electrooxidation of dopamine (DA) and uric acid (UA) were compared systematically. The sensing performances were found to be highly correlated with their morphologies. Among these morphologies, the nanoflower-like MnO2, composited with NG, displayed the most sensitive response signals for DA and UA. The boosted electrocatalytic activity was ascribed to the unique porous structure, large electroactive area, and low charge transfer resistance (Rct), which facilitated the electron transfer between electrode and analytes. Two linear response ranges (0.1 µM-10 µM and 10 µM-100 µM) were accompanied with very low detection limits of 34 nM and 39 nM for DA and UA, respectively. Moreover, the successful application of the MnO2NFs/NG composites for the simultaneous detection of DA and UA in human serum was realized using second-derivative linear sweep voltammetry (SDLSV). These findings give valuable insights for understanding the morphology-dependent sensing properties of MnO2 based nanomaterials, which is conducive to the rapid development of ubiquitous MnO2-based electrochemical sensors.

2.
J Neural Eng ; 17(2): 026001, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32000145

RESUMO

OBJECTIVES: With the rapid development of EEG-based wearable healthcare devices and brain-computer interfaces, reliable and user-friendly EEG sensors for EEG recording, especially at forehead sites, are highly desirable and challenging. However, existing EEG sensors cannot meet the requirements, since wet electrodes require tedious setup and conductive pastes or gels, and most dry electrodes show unacceptable high contact impedance. In addition, the existing electrodes cannot absorb sweat effectively; sweat would cause cross-interferences, and even short circuits, between adjacent electrodes, especially in the moving scenarios, or a hot and humid environment. To resolve these problems, a novel printable flexible Ag/AgCl dry electrode array was developed for EEG acquisition at forehead sites, mainly consisting of screen printing the Ag/AgCl coating, conductive sweat-absorbable sponges and flexible tines. APPROACH: A systematic method was also established to evaluate the flexible dry electrode array. MAIN RESULTS: The experimental results show the flexible dry electrode array has reproducible electrode potential, relatively low electrode-skin impedance, and good stability. Moreover, the EEG signals can be effectively captured with a high quality that is comparable to that of wet electrodes. SIGNIFICANCE: All the results confirmed the feasibility of forehead EEG recording in real-world scenarios using the proposed flexible dry electrode array, with a rapid and facile operation as well as the advantages of self-application, user-friendliness and wearer comfort.

3.
Biomolecules ; 9(6)2019 06 22.
Artigo em Inglês | MEDLINE | ID: mdl-31234553

RESUMO

In this study, we reported facile synthesis of Fe3O4/C composite and its application for the cost-effective and sensitive determination of tryptophan (Trp) in human serum samples. Fe3O4/C composites were prepared by a simple one-pot hydrothermal method followed by a mild calcination procedure, using FeCl3∙6H2O as Fe3O4 precursor, and glucose as reducing agent and carbon source simultaneously. The Fe3O4/C composite modified glassy carbon electrode (Fe3O4/C/GCE) was prepared by drop-casting method. The microstructure and morphology of Fe3O4/C composite was characterized by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Due to large specific surface area and synergistic effect from Fe3O4 nanoparticles and carbon coating, Fe3O4/C composite showed excellent electrocatalytic activity toward the oxidation of Trp. As a result, the proposed Fe3O4/C/GCE displayed superior analytical performances toward Trp determination, with two wide detection ranges (1.0-80 µM and 80-800 µM) and a low detection limit (0.26 µM, S/N = 3). Moreover, successful detection of Trp in human serum samples further validate the practicability of the proposed sensor.


Assuntos
Carbono/química , Análise Custo-Benefício , Eletroquímica/instrumentação , Limite de Detecção , Nanopartículas de Magnetita/química , Nanocompostos/química , Triptofano/análise , Eletroquímica/economia , Eletrodos , Humanos , Temperatura Ambiente , Fatores de Tempo , Triptofano/sangue , Triptofano/química
4.
Nanomaterials (Basel) ; 9(6)2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31159377

RESUMO

Various morphologies of iron oxide nanoparticles (Fe2O3 NPs), including cubic, thorhombic and discal shapes were synthesized by a facile meta-ion mediated hydrothermal route. To further improve the electrochemical sensing properties, discal Fe2O3 NPs with the highest electrocatalytic activity were coupled with graphene oxide (GO) nanosheets. The surface morphology, microstructures and electrochemical properties of the obtained Fe2O3 NPs and Fe2O3/GO nanohybrids were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. As expected, the electrochemical performances were found to be highly related to morphology. The discal Fe2O3 NPs coupled with GO showed remarkable electrocatalytic activity toward the oxidation of dopamine (DA) and uric acid (UA), due to their excellent synergistic effect. The electrochemical responses of both DA and UA were linear to their concentrations in the ranges of 0.02-10 µM and 10-100 µM, with very low limits of detection (LOD) of 3.2 nM and 2.5 nM for DA and UA, respectively. Moreover, the d-Fe2O3/GO nanohybrids showed good selectivity and reproducibility. The proposed d-Fe2O3/GO/GCE realized the simultaneous detection of DA and UA in human serum and urine samples with satisfactory recoveries.

5.
Nanomaterials (Basel) ; 9(6)2019 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-31159490

RESUMO

This study reports facile synthesis of MnO2 nanoflowers/N-doped reduced graphene oxide (MnO2NFs/NrGO) composite and its application on the simultaneous determination of dopamine (DA) and uric acid (UA). The microstructures, morphologies, and electrochemical performances of MnO2NFs/NrGO were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS), respectively. The electrochemical experiments showed that the MnO2NFs/NrGO composites have the largest effective electroactive area and lowest charge transfer resistance. MnO2NFs/NrGO nanocomposites displayed superior catalytic capacity toward the electro-oxidation of DA and UA due to the synergistic effect from MnO2NFs and NrGO. The anodic peak currents of DA and UA increase linearly with their concentrations varying from 0.2 µM to 6.0 µM. However, the anodic peak currents of DA and UA are highly correlated to the Napierian logarithm of their concentrations ranging from 6.0 µM to 100 µM. The detection limits are 0.036 µM and 0.029 µM for DA and UA, respectively. Furthermore, the DA and UA levels of human serum samples were accurately detected by the proposed sensor. Combining with prominent advantages such as facile preparation, good sensitivity, and high selectivity, the proposed MnO2NFs/NrGO nanocomposites have become the most promising candidates for the simultaneous determination of DA and UA from various actual samples.

6.
Phys Rev E ; 99(2-1): 022209, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30934286

RESUMO

We study theoretically and computationally the behavior of the classical and quantum parametrically periodically driven linear oscillator. As a basic paradigm of such a Floquet system we consider the case of the harmonic oscillation of the oscillator frequency, which is convenient to handle theoretically and computationally, while keeping the general features. We derive an explicit analytic formula for the quantum propagator in terms of the classical propagator. Using this, we derive the explicit exact formula for the evolution of the expectation value of the energy starting from an arbitrary normalizable initial state. In the case of the starting pure stationary eigenstate the evolution is exactly the same as for the classical microcanonical ensemble of initial conditions of the same starting energy. We perform a rather complete computational analysis of the system's behavior inside the instability regions (lacunae), where the energy of the oscillator increases exponentially, as well as in the stability regions, and in particular in the vicinity of the (in)stability borders. We confirm also numerically with absolute certainty that the borders of (in)stability regions classically and quantally coincide exactly, in accordance with the theory, which is an important check of the numerical accuracy of computations, and we find a number of important empirical results, especially an equation of the elliptic type describing the rate of exponential energy growth inside the lacunae in terms of other systems' quantities. We believe that our approach and findings are of generic linear type, i.e., applicable in most such linear Floquet systems, and we present a strong motivation for a general theory, classically and quantally.

7.
Exp Ther Med ; 16(4): 3617-3622, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30233717

RESUMO

Percutaneous kyphoplasty (PKP) has been used in Kümmell disease treatment for years. The objective of the current study was to evaluate the efficacy and safety of PKP in the treatment of patients with Kümmell disease and to explore the association between cement injection volume and pain relief. A total of 50 patients were enrolled in the present study and follow-up was 2 years. Efficacy was evaluated using the Visual Analog Scale (VAS), the Oswestry Disability Index (ODI) and the kyphotic angle (Cobb's angle). VAS and ODI were determined at the initial evaluation (prior to surgery), at 3 days, 3 months, and 1 and 2 years post surgery. Cobb's angle was measured prior to and 3 months, 1 year and 2 years following surgery. PKP safety was assessed by evaluating complications, including cement leakage and spinal cord compression. In the follow-ups, VAS significantly decreased from 7.00±0.78 pre-PKP to 3.14±0.67 at 2 years post-PKP (P<0.05). ODI significantly decreased from 73.88±8.60 prior to surgery to 22.84±8.85 at 1 year following surgery (P<0.05) and did not significantly change at the following 2-year measurement (26.44±8.63). The Cobb's angle, measured at 17.73±2.43° preoperatively, significantly decreased to 8.32±2.21° at 3 months following surgery (P<0.05). On subsequent follow-ups at 1 and 2 years, the Cobb's angle increased to 9.55±2.82 and 10.27±3.22°, respectively. A total of 8 patients exhibited signs of cement leakage during the PKP procedure. No patients experienced severe neurological deficits or complications. Spearman analysis demonstrated a positive correlation between cement injection volume and pain relief. The current study indicated that PKP was a safe and effective treatment for patients with Kümmell disease and that there was a positive correlation between cement injection volume and pain relief. The current study may be used a reference in cement dosing for the treatment of PKP.

8.
Molecules ; 23(9)2018 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-30149513

RESUMO

Control and detection of sunset yellow is an utmost demanding issue, due to the presence of potential risks for human health if excessively consumed or added. Herein, cuprous oxide-electrochemically reduced graphene nanocomposite modified glassy carbon electrode (Cu2O-ErGO/GCE) was developed for the determination of sunset yellow. The Cu2O-ErGO/GCE was fabricated by drop-casting Cu2O-GO dispersion on the GCE surface following a potentiostatic reduction of graphene oxide (GO). Scanning electron microscope and X-ray powder diffractometer was used to characterize the morphology and microstructure of the modification materials, such as Cu2O nanoparticles and Cu2O-ErGO nanocomposites. The electrochemical behavior of sunset yellow on the bare GCE, ErGO/GCE, and Cu2O-ErGO/GCE were investigated by cyclic voltammetry and second-derivative linear sweep voltammetry, respectively. The analytical parameters (including pH value, sweep rate, and accumulation parameters) were explored systematically. The results show that the anodic peak currents of Cu2O-ErGO /GCE are 25-fold higher than that of the bare GCE, due to the synergistic enhancement effect between Cu2O nanoparticles and ErGO sheets. Under the optimum detection conditions, the anodic peak currents are well linear to the concentrations of sunset yellow, ranging from 2.0 × 10-8 mol/L to 2.0 × 10-5 mol/L and from 2.0 × 10-5 mol/L to 1.0 × 10-4 mol/L with a low limit of detection (S/N = 3, 6.0 × 10-9 mol/L). Moreover, Cu2O-ErGO/GCE was successfully used for the determination of sunset yellow in beverages and food with good recovery. This proposed Cu2O-ErGO/GCE has an attractive prospect applications on the determination of sunset yellow in diverse real samples.


Assuntos
Compostos Azo/análise , Cobre/química , Técnicas Eletroquímicas , Eletrodos , Grafite/química , Nanocompostos/química , Óxidos/química , Concentração de Íons de Hidrogênio , Nanocompostos/ultraestrutura , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
9.
Med Sci Monit ; 23: 2333-2339, 2017 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-28515415

RESUMO

BACKGROUND The most appropriate management of Henoch-Schönlein Purpura (HSP) nephritis with nephrotic-range proteinuria remains uncertain. The aim of this study was to evaluate the clinical therapeutic effects of mycophenolate mofetil and low-dose steroid in Henoch-Schönlein purpura nephritis (HSPN) with nephrotic-range proteinuria and pathological classification less than IV in children. MATERIAL AND METHODS The clinical effects of MMF and low-dose steroid therapy were studied in children with Henoch-Schönlein purpura nephritis manifested with nephrotic-range proteinuria, normal kidney function, and <50% crescents or sclerosing lesions on renal biopsy. We enrolled 32 boys and 29 girls with nephrotic-range proteinuria, normal kidney function, and pathological classification less than IV on renal biopsy. We treated 41 cases (67.2%) with mycophenolate mofetil and low-dose prednisone combined therapy and 20 cases (32.8%) were treated with full-dose prednisone alone. RESULTS Short-term response was significantly different between 2 groups (χ²=4.371, P=0.037), while no significant difference was found in long-term prognosis (χ²=0.419, P=0.522) after follow-up. The ROC curve showed that the most appropriate cutoff value was 30.67 µg·h/ml for MPA-AUC and the area under the ROC curve was 0.731, with 85.2% sensitivity and 64.3% specificity. CONCLUSIONS Mycophenolate mofetil and low-dose prednisone combined therapy is a reasonable treatment choice which can promote the remission of proteinuria without increasing obvious adverse reactions in pediatric HSPN with nephrotic state and pathological classification less than grade IV. MPA-AUC more than 30 µg·h/ml was an appropriate value for MMF in the combined therapy with MMF and steroid for treating children with HSPN.


Assuntos
Ácido Micofenólico/uso terapêutico , Nefrite/tratamento farmacológico , Biópsia , Criança , Pré-Escolar , China , Quimioterapia Combinada , Feminino , Glomerulonefrite/tratamento farmacológico , Humanos , Imunossupressores/uso terapêutico , Rim/patologia , Masculino , Ácido Micofenólico/metabolismo , Nefrite/metabolismo , Prednisona/uso terapêutico , Proteinúria/patologia , Púrpura de Schoenlein-Henoch/tratamento farmacológico , Curva ROC , Estudos Retrospectivos , Esteroides/uso terapêutico
10.
Oncotarget ; 8(12): 18792-18801, 2017 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-27852046

RESUMO

Elevated inflammatory markers are associated with poor outcomes in various types of cancers; however, their clinical significance in multiple myeloma (MM) have seldom been explored. This study investigated the prognostic relevance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in MM. Totally 559 MM patients were included in this study. NLR, PLR and MLR were calculated from whole blood counts prior to therapy. Kaplan-Meier curves and multivariate Cox proportional models were used for the evaluation of the survival. It has shown that newly diagnosed MM patients were characterized by high NLR and MLR. Elevated NLR and MLR and decreased PLR were associated with unfavorable clinicobiological features. Applying cut-offs of 4 (NLR), 100 (PLR) and 0.3 (MLR), elevated NLR, MLR and decreased PLR showed a negative impact on outcome. Importantly, elevated NLR and decreased PLR were independent prognostic factors for progression-free survival. Thus, elevated NLR and MLR, and decreased PLR predict poor clinical outcome in MM patients and may serve as the cost-effective and readily available prognostic biomarkers.


Assuntos
Biomarcadores Tumorais/imunologia , Contagem de Leucócitos , Mieloma Múltiplo/imunologia , Adulto , Idoso , Área Sob a Curva , Plaquetas , Intervalo Livre de Doença , Feminino , Humanos , Hibridização in Situ Fluorescente , Estimativa de Kaplan-Meier , Linfócitos , Masculino , Pessoa de Meia-Idade , Monócitos , Mieloma Múltiplo/mortalidade , Mieloma Múltiplo/patologia , Neutrófilos , Prognóstico , Modelos de Riscos Proporcionais , Curva ROC , Sensibilidade e Especificidade
11.
Photodiagnosis Photodyn Ther ; 16: 15-16, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27491854

RESUMO

Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a disease characterized by multiple retinal macroaneurysms, neuroretinitis and peripheral capillary non-perfusion, leading to irreversible visual loss. It includes five stages and has previously been rarely reported. IRVAN syndrome is especially rare in Asia. In this report, we describe laser diagnosis and therapy in an Asian patient with IRVAN syndrome over two years of follow-up. We observed non-perfusion retina and dilated retinal capillaries in the contralateral eye. Photocoagulation is an effective therapy to control retinal macroaneurysms and nonperfusions and to prevent visual loss, particularly in the early stages of IRVAN syndrome (stages 2 & 3). To the best of our knowledge, this is the first long-term observation of photocoagulation in IRVAN syndrome. We discovered the early signs of such lesions, which may be beneficial for clinical diagnosis and therapy.


Assuntos
Aneurisma/terapia , Angiofluoresceinografia/métodos , Fotocoagulação/métodos , Vasculite Retiniana/diagnóstico , Vasculite Retiniana/terapia , Retinite/diagnóstico , Retinite/terapia , Aneurisma/diagnóstico , Feminino , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Síndrome , Resultado do Tratamento
12.
Oncol Lett ; 11(3): 1799-1806, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26998079

RESUMO

The bones are the most common location for metastases, which may cause severe pain and damage, including osteolytic destruction and fractures. Pathological fractures of the spine are extremely painful and cause significant disability and morbidity in patients. Traditional open surgery has numerous complications, and radiation therapy may take weeks to become effective. To avoid the trauma and complication of open surgery, percutaneous kyphoplasty (PKP) is a minimally invasive procedure that has played a great role in the treatment of spinal metastases over the past several years. To evaluate the efficacy and safety of the treatment of spinal metastasis using PKP, the present study evaluated 282 patients who had received PKP between April 2009 and June 2014. The efficacy of PKP was evaluated using the visual analog scale for pain (VAS), Karnofsky performance score (KPS) and quality of life (QOL) score (short form with 36 questions). The KPS and QOL were measured pre-operatively and 3 months post-operatively. In addition, radiographical data, including the degree of restoration of the kyphotic angle and the anterior vertebral height, and leakage of bone cement, were measured. The safety of the surgery was assessed by complications and side effects reported during or subsequent to surgery. The present study measured the parameters prior to the surgery and at 24 h, 3 months, 6 months and 1 year post-surgery, as well as at the last follow-up date. The range of the follow-up time was between 105 days and 15 months (mean, 401 days). The 282 patients underwent successful operations and the pain felt by the patients prior to the surgery was significantly alleviated. In addition, the analgesic intake of patients greatly decreased following PKP. KPS improved prior to and 3 months after the surgery. QOL also improved prior to and 3 months after the surgery. Radiographical data demonstrated that the kyphotic angle decreased following PKP, and the anterior vertebral height increased. Paravertebral leakage of bone cement occurred in 10 patients through a cortical defect, but without spinal cord compression or pulmonary embolism. Therefore, as a minimally invasive procedure, PKP may not only rapidly relieve the pain and disability experienced by patients, but it may also restore the kyphotic angle observed at the 1-year follow-up. Notably, PKP may safely improve the QOL of patients.

14.
PLoS One ; 8(7): e68476, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23844207

RESUMO

BACKGROUND: The purpose of this study was to introduce a novel, simple and effective technique for creating a reliable rabbit model of abdominal aortic aneurysm (AAA) via a combination of periaortic calcium chloride (CaCl2) and elastase incubation. METHODS: Forty-eight New Zealand white rabbits were divided into four groups. The AAA model was developed via a 20-minute periaortic incubation of CaCl2 (0.5 mol/L) and elastase (1 Unit/µL) in a 1.5-cm aortic segment (Group CE). A single incubation of CaCl2 (Group C) or elastase (Group E) and a sham operation group (Sham Group) were used for the controls. Diameter was measured by serial digital subtraction angiography imaging on days 5, 15 and 30. Animals were sacrificed on day 5 and day 30 for histopathological and immunohistochemical studies. RESULTS: All animals in Group CE developed aneurysm, with an average dilation ratio of 65.3% ± 8.9% on day 5, 86.5% ± 28.7% on day 15 and 203.6% ± 39.1% on day 30. No aneurysm was found in Group C, and only one aneurysm was seen on day 5 in Group E. Group CE exhibited less intima-media thickness, endothelial recovery, elastin and smooth muscle cell (SMC) content, but stronger expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and RAM11 compared to the controls. CONCLUSIONS: The novel rabbit model of AAA created by using a combination of periaortic CaCl2 and elastase incubation is simple and effective to perform and is valuable for elucidating AAA mechanisms and therapeutic interventions in experimental studies.


Assuntos
Aorta Abdominal/metabolismo , Aneurisma da Aorta Abdominal/induzido quimicamente , Aneurisma da Aorta Abdominal/metabolismo , Modelos Animais de Doenças , Angiografia Digital , Animais , Aorta Abdominal/diagnóstico por imagem , Aorta Abdominal/patologia , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Cloreto de Cálcio , Espessura Intima-Media Carotídea , Elastina/metabolismo , Humanos , Intubação , Metaloproteinase 2 da Matriz/metabolismo , Metaloproteinase 9 da Matriz/metabolismo , Elastase Pancreática , Coelhos
15.
Clinics (Sao Paulo) ; 68(5): 628-31, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23778422

RESUMO

OBJECTIVES: Familial steroid-sensitive idiopathic nephrotic syndrome is rare, and only approximately 3% of patients have affected siblings. METHODS: Herein, we report seven cases of patients with steroid-sensitive idiopathic nephrotic syndrome from three Chinese families. Mutational screening of the Nphs2 gene was performed in all the patients. RESULTS: All seven of the familial steroid-sensitive idiopathic nephrotic syndrome cases in our sample exhibited minimal change disease, and one case also presented with mesangial proliferative glomerulonephritis, according to the renal pathology. No significant was associations were found between Nphs2 gene mutations and the onset of proteinuria and nephrotic syndrome in these familial cases. CONCLUSIONS: The presence of minimal change disease is important, but it is not an unusual finding in patients with familial steroid-sensitive idiopathic nephrotic syndrome, which appears to be clinically benign and genetically distinct from other types of nephrosis.


Assuntos
Peptídeos e Proteínas de Sinalização Intracelular/genética , Proteínas de Membrana/genética , Mutação/genética , Síndrome Nefrótica/genética , Polimorfismo Genético/genética , Doenças Raras/genética , Adolescente , Adulto , Criança , Pré-Escolar , China , Feminino , Humanos , Masculino , Síndrome Nefrótica/patologia , Linhagem , Doenças Raras/patologia
16.
Zhonghua Yi Xue Za Zhi ; 93(7): 531-3, 2013 Feb 19.
Artigo em Chinês | MEDLINE | ID: mdl-23660324

RESUMO

OBJECTIVE: To evaluate the effects of catheter-direct thrombolysis in acute deep venous thrombosis (DVT). METHODS: A total of 86 cases were divided into 2 groups of peripheral venous thrombolysis (group A, n = 33) and catheter-direct thrombolysis (group B, n = 53). The curative effect of two groups was compared by swelling rate and vascular potency. RESULTS: No significant difference existed in swelling rate between two groups (P > 0.05). Vascular patency rates of group B was significantly better than those of group A (P < 0.01). The incidence of bleeding had no significant difference (P > 0.05) and there was no asymptomatic pulmonary embolism in two groups. CONCLUSION: Both treatments of acute DVT are effective in improving symptoms. But catheter-directed thrombolysis results in significant vascular patency rate and does not increase the risk of thrombolytic bleeding.


Assuntos
Terapia Trombolítica/métodos , Trombose Venosa/tratamento farmacológico , Adulto , Idoso , Cateterismo Periférico , Feminino , Humanos , Extremidade Inferior/irrigação sanguínea , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
17.
World J Pediatr ; 9(2): 163-8, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23677832

RESUMO

BACKGROUND: This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis. METHODS: The patients were divided into two groups: 215 patients with asymptomatic isolated microhematuria (AIMH; proteinuria <0.1 g/day) and 136 patients with persistent asymptomatic microhematuria, recurrent macrohematuria and/or proteinuria (AMHP; proteinuria 0.1-0.25 g/day). After kidney biopsy, the patients were monitored for 2-10 years. RESULTS: Normal biopsies or minor abnormalities were more frequent in AIMH patients than those in AMHP patients, who exhibited IgA nephropathy more frequently. During the 2- to 10-year follow-up period, adverse renal events (i.e., development of proteinuria, hypertension, or impaired renal function) were observed in 13/215 (6.0%) patients with AIMH and 31/136 (22.8%) patients with AMHP (χ(2)=15.521, P<0.001). CONCLUSIONS: Normal biopsies or minor abnormalities were more frequently observed in AIMH patients, whereas IgA nephropathy and adverse renal events were more frequent in AMHP. Microscopic hematuria, especially when accompanied by macroscopic hematuria and proteinuria, may represent an important risk factor for the development of chronic kidney disease.


Assuntos
Doenças Assintomáticas , Hematúria/patologia , Adolescente , Biópsia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Prognóstico
18.
Clinics ; 68(5): 628-631, maio 2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-675765

RESUMO

OBJECTIVES: Familial steroid-sensitive idiopathic nephrotic syndrome is rare, and only approximately 3% of patients have affected siblings. METHODS: Herein, we report seven cases of patients with steroid-sensitive idiopathic nephrotic syndrome from three Chinese families. Mutational screening of the Nphs2 gene was performed in all the patients. RESULTS: All seven of the familial steroid-sensitive idiopathic nephrotic syndrome cases in our sample exhibited minimal change disease, and one case also presented with mesangial proliferative glomerulonephritis, according to the renal pathology. No significant was associations were found between Nphs2 gene mutations and the onset of proteinuria and nephrotic syndrome in these familial cases. CONCLUSIONS: The presence of minimal change disease is important, but it is not an unusual finding in patients with familial steroid-sensitive idiopathic nephrotic syndrome, which appears to be clinically benign and genetically distinct from other types of nephrosis. .


Assuntos
Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Peptídeos e Proteínas de Sinalização Intracelular/genética , Proteínas de Membrana/genética , Mutação/genética , Síndrome Nefrótica/genética , Polimorfismo Genético/genética , Doenças Raras/genética , China , Síndrome Nefrótica/patologia , Linhagem , Doenças Raras/patologia
19.
Indian Pediatr ; 49(10): 831-3, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23144102

RESUMO

IgM nephropathy presents with refractory nephrotic syndrome and its treatment is a significant challenge for pediatricians. We present two patients with IgM nephropathy and frequently relapsing nephrotic syndrome treated with rituximab and subsequently mycophenolate mofetil. Both showed complete remission, which 24 to 30 months later, was still maintained. The role of mycophenolate mofetil therapy in maintaining remission after successful treatment of rituximab in IgM nephropathy needs to be examined.


Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Imunoglobulina M , Fatores Imunológicos/uso terapêutico , Ácido Micofenólico/análogos & derivados , Síndrome Nefrótica/tratamento farmacológico , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Ácido Micofenólico/uso terapêutico , Rituximab
20.
Pediatr Nephrol ; 27(11): 2073-2079, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22714672

RESUMO

BACKGROUND: Cyclosporine A (CsA) and tacrolimus (TAC) are often alternative treatment choices for patients with nephrotic syndrome. METHODS: In this prospective study, the efficacy and safety of CsA and TAC in inducing and maintaining remission in 74 children with idiopathic nephrotic syndrome (INS) were evaluated. RESULTS: In terms of short-term efficacy, TAC was more effective than CsA in children with steroid-resistant nephrotic syndrome (χ(2) = 13.75, P = 0.001), although no significant difference in number of episodes of relapse were found in patients with complete remission between the two treatment groups (first year: χ(2) = 0.261, P = 0.88; second year: χ(2) = 2.685, P = 0.26). In patients with frequently relapsing or steroid-dependent nephrotic syndrome, no significant difference in short-term remission (χ(2) = 1.908, P = 0.39) or in relapse frequency during follow-up (within first year: χ(2) = 1.046, P = 0.59; within second year: χ(2) = 0.587, P = 0.75) were found between the two groups. There was a difference in the rate of adverse effects between the two treatment groups [nephrotoxicity: 4/24 (CsA) vs .0/50 (TAC), P = 0.002; hirsutism: 8/24 (CsA) vs. 0/50 (TAC), P < 0.001]. CONCLUSIONS: In our pediatric patient cohort, the treatment of steroid-resistant nephrotic syndrome with tacrolimus was associated with higher efficacy and lower renal toxicity in comparison to CsA, although no favorable outcome in relapse rate during long-term follow-up was seen. On the other hand, tacrolimus was not always the better choice to replace CsA in the treatment of severe frequently relapsing or steroid-dependent nephrotic syndrome.


Assuntos
Ciclosporina/uso terapêutico , Imunossupressores/uso terapêutico , Síndrome Nefrótica/congênito , Tacrolimo/uso terapêutico , Adolescente , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Ciclosporina/efeitos adversos , Feminino , Humanos , Imunossupressores/efeitos adversos , Masculino , Síndrome Nefrótica/diagnóstico , Síndrome Nefrótica/tratamento farmacológico , Estudos Prospectivos , Recidiva , Indução de Remissão , Tacrolimo/efeitos adversos , Fatores de Tempo , Resultado do Tratamento
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