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1.
BMC Cancer ; 21(1): 188, 2021 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-33622258

RESUMO

BACKGROUND: Gastric outlet obstruction (GOO) is a late complication of advanced gastric cancer, and it is controversial how to select the therapeutic strategies: gastrojejunostomy and palliative gastrectomy? Therefore, this study was to compare the surgical and survival outcomes of gastrojejunostomy and palliative gastrectomy. METHODS: In total, 199 gastric cancer patients with outlet obstruction treated by surgery between January 2000 and December 2015 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Patients were divided into gastrojejunostomy group and palliative gastrectomy group. Propensity score matching (PSM) was performed to balance the selection bias. RESULTS: After 1:1 PSM, a total of 104 patients were included for final analysis. The median overall survival (OS) times in the gastrojejunostomy group and palliative gastrectomy group were 8.50 and 11.87 months, respectively (P = 0.243). The postoperative complication rates in the gastrojejunostomy group and palliative gastrectomy group were 19.23% (10/52) and 17.31% (9/52), respectively (P = 0.800), and no treatment-related death was observed. Multivariate analysis showed that periton0eal seeding (P = 0.014) and chemotherapy (P < 0.001) were independent prognostic factors. Among them, peritoneal seeding was a risk factor and postoperative chemotherapy was a protective factor. CONCLUSIONS: Our results indicated that although the surgical complications of palliative gastrectomy were manageable, it showed no survival benefit. Therefore, relieving obstruction symptom, improving patients' quality of life and creating better conditions for chemotherapy appear to be the main therapeutic strategies for advanced gastric cancer with GOO.

2.
J Asian Nat Prod Res ; : 1-8, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33583289

RESUMO

Two new compounds, including one new arylbenzofuran (1) and one new pterocarpanoid (2), along with nine known ones, were isolated from the seeds of Sophora tonkinensis. The structures of the new compounds were elucidated based on a comprehensive spectroscopic data analysis. Compounds 2 and 3 exhibited good anti-tobacco mosaic virus (TMV) activities with the protective inhibition rate of 69.62% and 68.72% respectively, at concentration of 100 µg/ml.

3.
Nat Prod Bioprospect ; 2021 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-33575932
4.
Clin Neuropharmacol ; 44(1): 5-8, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33449474

RESUMO

INTRODUCTION: The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients. METHODS: We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model. RESULTS: Five randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, vitamin D treatment is associated with substantially reduced number of headache days (standard mean difference [SMD], -0.53; 95% confidence interval [CI], -0.83 to -0.23; P = 0.0006), frequency of headache attacks (SMD, -1.09; 95% CI, -1.86 to -0.32; P = 0.006), headache severity (SMD, -0.55; 95% CI, -0.91 to -0.19; P = 0.0003), and Migraine Disability Assessment score (SMD, -0.76; 95% CI, -1.11 to -0.40; P < 0.0001). CONCLUSIONS: Vitamin D treatment is effective to alleviate migraine.

5.
Org Biomol Chem ; 19(7): 1541-1545, 2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-33503103

RESUMO

Three novel jatrophane diterpenes, cyclojatrophanes A-C (1-3), were isolated from the seeds of Euphorbia peplus. Compounds 1-3 featured an unprecedented 5/5/5/11 tetracyclic ring system incorporating ditetrahydropyran rings. Their structures including their absolute configurations were established by extensive spectroscopic analysis, X-ray crystallographic experiments and chemical transformations. In addition, these compounds could significantly activate the lysosomal-autophagy pathway.

6.
Int J Phytoremediation ; : 1-9, 2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33501836

RESUMO

To screen the efficient tree-herb co-planting patterns to remediate the heavy metal polluted soil, a greenhouse experiment was conducted for 150 days to examine the plant growth and metals accumulation across three co-planting patterns, including Solanum nigrum (S) co-planted with Quercus nuttallii (NS) or Quecrus pagoda (PS), and those three species are co-planted together (NPS). Results showed that the NPS pattern slightly decreased the tree biomass, while NS and PS treatments improved the plant growth (1.51-10.68%). It is worth noting that the NS treatment significantly (p < 0.05) increased photosynthetic pigment content (82.61-113.93%), net CO2 assimilation (21.44%), and the uptake of Cd (44.58%) in Q. nuttallii; the PS treatment significantly (p < 0.05) increased the net CO2 assimilation (8.61%) and the uptake of Cd (42.23%), Zn (31.18%) in Q. pagoda; and the uptake of Cd and Zn in the NPS co-planting treatment were only slightly increased. For S. nigrum, the photosynthetic pigment content was elevated and the metal accumulation in itself also maintained the relative stable in all the co-planting treatments. Thus, co-planting of Quercus with S. nigrum was a promising way to remediate heavily polluted soil by heavy metals. Novelty statement: Co-planting with multiple plant species, as a novel strategy, has great value for the remediation of heavy metal contaminated soil. The paper aimed to explore the suitable co-planting pattern of Quercus, arbor trees which showed phytoremediation potential, co-planted with Cd hyperaccumulator, Solanum nigrum. The result suggested the co-planting with S. nigrum enhanced the plant growth, photosynthesis, and metals extraction of Q. nuttallii and Q. pagoda. Co-planting also improved ecological adaptation of S. nigrum via elevating pigment content. Thus, co-planting of Quercus with S. nigrum was a promising way to remediate polluted soil.

7.
Spectrochim Acta A Mol Biomol Spectrosc ; 245: 118888, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-32947159

RESUMO

In this study, the feasibility of estimation and forecast of different vitality Quercus variabilis seeds by a hyperspectral imaging technique were investigated. Artificially accelerated aging was conducive to achieve the division of four vitality levels. Hyperspectral data in the first 10 h of germination were continuously collected at one-hour intervals. The optimal band was selected for the original and pre-processed spectra which were treated by multiple scatter correction (MSC) and the Savitzky-Golay first derivative (SG 1st). Five characteristic wavelength methods were compared: successive projections algorithm (SPA), competitive adaptive reweighted sampling (CARS), genetic algorithm (GA), variable important in projection (VIP), and random frog (RF). Partial least square-discriminant analysis (PLS-DA) and K-nearest neighbor (KNN) built the vitality estimation model based on different data sets, and GA + PLS-DA constructed the optimal model with the highest accuracy. According to the weight coefficient and reflectance of the characteristic band extracted by the GA, the reflectance curves of different levels over time were plotted. The data of 0 h was employed to establish the vitality forecast model. The forecast model had a high recognition rate, with PLS-DA exceeding 99% and KNN exceeding 85%. This indicated that hyperspectral imaging of seed germination processes could achieve non-destructive estimation of Q. variabilis seed vitality, and accurate prediction in a shorter time is feasible.

8.
Bioorg Chem ; : 104515, 2020 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-33272708

RESUMO

Nineteen indole alkaloids including eleven new ones, taberdines A-K (1-11), were isolated from Tabernaemontana divaricata. Their structures were assigned by MS, NMR, single crystal X-ray diffractions, and ECD analyses. Alkaloid 1 is an aspidosperma-type monoterpenoid indole alkaloid and possesses a rearranged pyrrolidine moiety due to C-3 degradation, and 4 has a rare 1,3-oxazolidine moiety within iboga-type alkaloids. Alkaloids 2, 4, 6, and 11-19 combined with 5 µg/mL fluconazole exhibited significant activity to reverse fluconazole resistance in Candida albicans strains while no one used alone showed any activities against the resistant strain.

9.
Org Lett ; 2020 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-33284631

RESUMO

Harpertrioate A (1), an A,B,D-seco-limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of Harrisonia perforata twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing Aß42 and Aß40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of 1 on the Aß production was comparable to that of gemfibrozil.

10.
Chin Med J (Engl) ; 2020 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-33278100

RESUMO

BACKGROUND: Studies have reported that low bone mineral density (BMD) is prevalent in human immunodeficiency virus (HIV)-infected patients; however, the factors that contribute to HIV-related BMD changes are yet to be fully understood. Due to the application of dual X-ray absorptiometry (DXA) among a select group of hospitals only, the prevalence and risk factors of low BMD in HIV-infected populations have not been intensively investigated in China. Thus, the aim of our study was to investigate the prevalence of and risk factors associated with BMD changes among antiretroviral therapy (ART)-naive HIV-positive patients in China. METHODS: The assessment of the prevalence of and risk factors associated with BMD changes was conducted among 156 ART-naive HIV-infected patients. Demographic and clinical data, as well as fasting blood levels were obtained from patients. Further, all patients underwent DXA scans to determine BMD, which was then used to classify patients with osteopenia/osteoporosis. The risk factors of reduced BMD were then evaluated using binary logistic regression. RESULTS: Among the 156 ART-naive HIV-infected participants, osteopenia and osteoporosis were diagnosed in 48.7% (76/156) and 4.5% (7/156) of patients, respectively. The lumbar spine was most likely to have reduced BMD (49.4% [77/156]), and the proportion of osteopenia in the left hip (32.7% [51/156]) was higher than in the right hip (24.4% [38/156]). In the lumbar spine, bone loss rate in the L1 section (60.9% [95/156]) was the most significant (L2, 53.2% [83/156]; L3, 45.5% [71/156]; L4, 52.6% [82/156]). Further analysis showed that, compared with the neck (26.9% [42/156] in the left, 18.6% [29/156] in the right) and the interior (15.4% [24/156] in the left, 13.5% [21/156] in the right), the trochanter had the greatest probability of reduced BMD (46.2% [72/156] in the left, 28.8% [45/156] in the right). In the risk factor analysis, low body mass index (BMI: <18.5 kg/m) was positively associated with reduced BMD (Exp (B) = 39.743, 95% confidence interval: 3.234-488.399, P = 0.004), and was specifically positively correlated with BMD values at three sites (r = 0.335 at right hip, r = 0.327 at left hip, r = 0.311 at CONCLUSION: Reduced BMD was found in the majority of ART-naive HIV-infected patients and BMI was identified as an additional risk factor for reduced BMD. Our results show that BMD reduction was simultaneously present in the left hip, right hip, and lumbar spine among more than a third of patients. Our work highlights the importance of closely monitoring BMD in ART-naive patients and provides a foundation for the clinical intervention of bone demineralization in them.

12.
Bioorg Chem ; : 104519, 2020 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-33293058

RESUMO

Chemical investigation of the twigs and leaves of Rhodomyrtus tomentosa led to the isolation and structural identification of a novel polymethylated phloroglucinol meroterpenoid (PPM) featuring a 6/6/6/6 tetracyclic system, rhotomentodione F (1), five new polymethylated polycyclic phloroglucinols (PPPs) with a rare bis-furan framework, rhotomentosones A-E (2-6), and one new adduct composed of an acylphloroglucinol and two ß-triketone units, rhotomentosone F (7), as well as five known analogues (8-12). Their structures and absolute configurations were unambiguously determined by comprehensive spectroscopic data and electronic circular dichroism (ECD) calculations. All isolates were evaluated for their anti-inflammatory and acetylcholinesterase (AChE) inhibitory activities. Compound 6 displayed significant AChE inhibitory effect with an IC50 value of 8.68 µM. Further molecular docking studies of 6 revealed that the interactions with AChE residues Ser125, Glu202, and Tyr133 are crucial for AChE inhibitory activity. The current study not only enriches the chemical diversity of phloroglucinols in Myrtaceae species, but also provides potential lead compounds for the further design and development of new AChE inhibitors to treat Alzheimer's disease.

13.
BMC Infect Dis ; 20(1): 912, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33261581

RESUMO

BACKGROUND: Despite the profound impact of antiretroviral therapy in the control of AIDS mortality, central nervous system opportunistic infections remains a significant burden in AIDS patients. This retrospective study aims to elucidate the clinical characteristics, outcome and risk factors of cryptococcal meningitis (CM) poor prognosis in AIDS patients from a tertiary hospital in China. METHODS: Clinical data from 128 patients admitted in Beijing Ditan Hospital, Capital Medical University from November 2008 to November 2017 was collected. The cohort was stratified based on treatment outcome (effective 79%, and ineffective 21%), and Multivariate Logistic regression analysis used to identify risk factors of poor disease prognosis. RESULTS: Age, incidence of cerebral infarction, the proportion of consciousness disorder, and fasting plasma glucose was higher in the ineffective treatment group than the effective treatment group. The duration of treatment in the induction period of the ineffective group was significantly shorter than that of the effective group. Multivariate Logistic regression analysis indicated that the occurrence of cerebral hernia and consciousness disorder were risk factors for the prognosis of AIDS patients with CM infection, while the duration of treatment in the induction period was a indicative of a better prognosis in AIDS with CM infection complications. Finally, shunt decompression therapy correlated with a better disease outcome. CONCLUSIONS: This retrospective study exposes the main risk factors associated with worse disease prognosis in AIDS patients with CM infection complications.

14.
Neural Plast ; 2020: 8842110, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33299396

RESUMO

Musculoskeletal pain (MSP) is one of the most severe complaints in women undergoing menopause. The prevalence of MSP varied when taking the menopausal state and age factor into consideration. This study investigated the prevalence of MSP in perimenopausal women and its association with menopausal state. The MEDLINE, Embase, Web of Science, and PubMed databases were searched from inception to July 2020, and 16 studies were retrieved for the current meta-analysis. The primary outcome measure was the MSP Odds Ratio (OR). The estimated overall prevalence of MSP among perimenopausal women was 71% (4144 out of 5836, 95% confidence interval (CI): 64%-78%). Perimenopausal women demonstrated a higher risk for MSP than premenopausal ones (OR: 1.63, 95% CI: 1.35-1.96, P = 0.008, I 2 = 59.7%), but similar to that in postmenopausal ones (OR: 1.07, 95% CI: 0.95-1.20, P = 0.316, I 2 = 13.4%). The postmenopausal women were at a higher risk of moderate/severe MSP than the premenopausal ones (OR: 1.45, 95% CI: 1.21-1.75, P = 0.302, I 2 = 16.5%) or the perimenopausal ones (OR: 1.40, 95% CI: 1.09-1.79, P = 0.106, I 2 = 55.4%). In conclusion, the perimenopause is a state during which women are particularly predisposed to develop MSP. As to moderate to severe degrees of MSP, the odds increase linearly with age, from premenopause to peri- and then to postmenopause.

15.
Zhonghua Nan Ke Xue ; 26(9): 832-837, 2020 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-33377709

RESUMO

Metastasis is an adverse factor in the recovery of prostate cancer, and oligometastatic prostate cancer is a disease different from localized and widespread metastatic prostate cancer. The patients may benefit from local treatment in terms of quality of life and survival time. Concerning the existing methods for the diagnosis and treatment of oligometastatic metastatic prostate cancer, researchers have advanced various views, such as "further elaboration of methodology", "specificity in the choice of treatment", and "better consideration of both local and systemic treatments". This review outlines recent advances in the studies of oligometastatic prostate cancer, hoping to provide some ideas benefiting the treatment of the malignancy.


Assuntos
Metástase Neoplásica/terapia , Neoplasias da Próstata/terapia , Humanos , Masculino , Qualidade de Vida
16.
PLoS One ; 15(12): e0243773, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33351812

RESUMO

The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18-78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3-2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7-3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4-5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2-14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9-15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1-13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs.


Assuntos
Síndrome de Imunodeficiência Adquirida/epidemiologia , Efeitos Psicossociais da Doença , Síndrome de Imunodeficiência Adquirida/diagnóstico , Síndrome de Imunodeficiência Adquirida/tratamento farmacológico , Síndrome de Imunodeficiência Adquirida/imunologia , Distribuição por Idade , Idoso , Fármacos Anti-HIV/uso terapêutico , Contagem de Linfócito CD4 , China/epidemiologia , Estudos de Coortes , Interações Medicamentosas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico
17.
Phytochemistry ; 181: 112566, 2020 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-33197743

RESUMO

Fourteen undescribed monoterpenoid indole alkaloids, voacafrines A-N, along with 7 known monoterpenoid indole alkaloids were isolated from the seeds of Voacanga africana Stapf. Among them, voacafrines A-G were aspidosperma-aspidosperma type bisindole alkaloids, while voacafrines H-N were aspidosperma-type monomers. Their structures and absolute configurations were elucidated by a combination of NMR, MS, and ECD analyses. Voacafrines A-C were characterized by an acetonyl moiety at C-5', while voacafrine H possessed a methoxymethyl moiety at C-14 within aspidosperma-type alkaloids. The acetylcholinesterase (AChE) inhibitory activity and cytotoxicity of voacafrines A-N were evaluated. Voacafrines A-C and E-G were bisindole alkaloids that exhibited AChE inhibitory activity with IC50 values of 4.97-33.28 µM, while voacafrines I and J were monomers that showed cytotoxicity against several human cancer cell lines with IC50 values of 4.45-7.49 µM.

18.
Nat Commun ; 11(1): 5989, 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33214567

RESUMO

A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19873-9.

20.
Org Biomol Chem ; 2020 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-33180084

RESUMO

Hypsampsone A (1) and hyperhexanone F (2), two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii. Hypsampsone A (1) features the first spirocyclic system fused with 5/6/5/5 tetracyclic skeleton. Hyperhexanone F (2) represents the second novel 1,2-seco-bicyclo[3.3.1]-PPAP skeleton. Their structures were established by extensive spectroscopic analysis, computer-assisted structure elucidation software, and calculated electronic circular dichroism spectra. A plausible biogenetic pathway of 1 was also proposed. Compounds 1 and 2 showed moderate multidrug resistance reversal activity to adriamycin (ADR) resistant cancer cell lines, HepG2/ADR and MCF-7/ADR, with the fold-reversals ranging from 16 to 38 at noncytotoxic concentration of 10 µM.

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