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1.
Nat Prod Bioprospect ; 12(1): 13, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-35359233

RESUMO

Air pollution adversely affects skin, leading to skin inflammation and premature skin aging. Plant derived antioxidant compounds have been considered to be promising in discovery of effective agents for the protection of skin from the damage by air pollutants. Our previous studies demonstrated that Averrhoa carambola fruit (known as star fruit) is rich in flavonoid C-glycosides with unique structures and potent antioxidant activity. Thus, the star fruit extract (SFE) and main flavonoid C-glycoside components, carambolasides I, J, and P (1-3), carambolaflavone B (4), and isovitexin 2″-O-α-L-rhamnoside (5), were investigated for the activity against air pollutant stress in human epidermis. As a result, SFE and compounds 1-5 exhibited significant inhibitory activity against protein carbonylation in oxidative-stressed stratum corneum with the best activity being shown by compound 3. SFE and compounds 2-5 were also active against engine exhaust-induced protein carbonylation in stratum corneum. When further evaluated, SFE and compound 3 significantly inhibited gene expression of the key inflammation mediators IL-1α and COX-2 in PM-stressed keratinocytes. The results indicated that SFE and the flavonoid C-glycosides are potentially effective against air pollutant-induced skin inflammation and premature aging.

2.
World J Clin Cases ; 9(20): 5737-5743, 2021 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-34307633

RESUMO

BACKGROUND: Adrenocortical carcinoma (ACC) is a rare malignant epithelial tumor originating from adrenocortical cells that carries a very poor prognosis. Metastatic or inoperable diseases are often considered incurable, and treatment remains a challenge. Especially for advanced cases such as ACC complicated with renal venous cancer thrombus, there are few cumulative cases in the literature. CASE SUMMARY: The patient in this case was a 39-year-old middle-aged male who was admitted to the hospital for more than half a month due to dizziness and chest tightness. Computed tomography (CT) findings after admission revealed a left retroperitoneal malignant space-occupying lesion, but the origin of the formation of the left renal vein cancer thrombus remained to be determined. It was speculated that it originated from the left adrenal gland, perhaps a retroperitoneal source, and left adrenal mass + left nephrectomy + left renal vein tumor thrombus removal + angioplasty were performed under general anesthesia. Postoperative pathology results indicated a diagnosis of ACC. Postoperative steroid therapy was administered. At 3 mo after surgery, abdominal CT reexamination revealed multiple enlarged retroperitoneal lymph nodes and multiple low-density shadows in the liver, and palliative radiotherapy and mitotane were administered, considering the possibility of metastasis. The patient is currently being followed up. CONCLUSION: ACC is a highly malignant tumor. Even if the tumor is removed surgically, there is still the possibility of recurrence. Postoperative mitotane and adjuvant chemoradiotherapy have certain benefits for patients, but they cannot fully offset the poor prognosis of this disease.

3.
Chin Med J (Engl) ; 134(13): 1610-1615, 2021 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-34133348

RESUMO

BACKGROUND: Perioperative neurocognitive disorders (PND) are a series of severe complications in the perioperative and anesthetic periods with a decline in memory, execution ability, and information processing speed as the primary clinical manifestation. This study aimed to evaluate the impact of edaravone (EDA) on PND and peripheral blood C-X-C motif chemokine ligand 13 (CXCL13) levels in elderly patients with hip replacement. METHODS: A total of 160 elderly patients undergoing hip arthroplasty in Affiliated Dongguan People's Hospital of Southern Medical University (from March 2016 to March 2018) were randomly and double-blindly categorized into an EDA group and a control group (CON). Group EDA was administered intravenously EDA 30 min before surgery, and group CON was administered intravenously saline. The cognitive function of the two groups was evaluated 1-day before the operation and at 1 and 12 months after surgery, and the incidence of post-operative delirium was tested on days 1, 3, and 7 after surgery using the Chinese version of the confusion assessment method. Serum CXCL13 and interleukin (IL)-6 concentrations were measured before anesthesia, during surgery (30 min after skin incision), and on days 1, 3, and 7 after surgery. The continuous variables in accordance with normal distribution were tested using the Student's t test, the continuous variables without normal distribution using the Mann-Whitney U test, and categorical variables by the χ2 test or Fisher exact test. RESULTS: The incidence of post-operative delirium within 7 days after surgery was significantly higher in group CON than that in group EDA (31.3% vs. 15.0%, t = -5.6, P < 0.001). The modified telephone interview for cognitive status and activities of daily life scores were significantly higher in the group EDA than those in the group CON at 1 month (39.63 ±â€Š4.35 vs. 33.63 ±â€Š5.81, t = -2.13, P < 0.05 and 74.3 ±â€Š12.6 vs. 61.2 ±â€Š13.1, t = -1.69, P < 0.05) and 12 months (40.13 ±â€Š5.93 vs. 34.13 ±â€Š5.36, t = -3.37, P < 0.05 and 79.6 ±â€Š11.7 vs. 65.6 ±â€Š16.6, t = -2.08, P < 0.05) after surgery; and the incidence of neurocognitive dysfunction was significantly lower in the group EDA than that in the group CON (P < 0.05). Serum CXCL13 and IL-6 concentrations were significantly lower in the group EDA than those in the group CON during and after surgery (P < 0.05). CONCLUSION: EDA can significantly reduce the serum concentrations of CXCL13 and IL-6 and improve the PND of patients.


Assuntos
Artroplastia de Quadril , Quimiocinas CXC/efeitos dos fármacos , Delírio , Idoso , Artroplastia de Quadril/efeitos adversos , Quimiocinas CXC/sangue , Método Duplo-Cego , Edaravone , Humanos , Ligantes , Complicações Pós-Operatórias
4.
Zhong Yao Cai ; 37(6): 992-5, 2014 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-25470965

RESUMO

OBJECTIVE: To study the chemical constituents from the capitula of Eriocaulon australe. METHOD: The compounds were isolated and purified by column chromatography and their structures were determined through spectroscopic techniques (NMR)and physicochemical properties. RESULTS: Six compounds were identified from capitula of Eriocaulon australe as (R)-semixanthomegnin( 1) ,tora-lactone-9-0-ß-D-glucopyranoside(2), ( - ) -semivioxanthin-9-0-ß-D-glucopyranoside( 3) ,4-ketopinoresinol(4) ,ß-daucosterol (5) and 3,3'-dihydroxy-4,4'-dimethoxybiphenyl(6). CONCLUSION: Compounds 1 ~ 6 are isolated from this plant and compounds 3 ~ 6 are ob- tained from Eriocaulon genus for the first time. Compound 1 shows DNA scission activity.


Assuntos
Poaceae/química , Espectroscopia de Ressonância Magnética
5.
J Agric Food Chem ; 61(48): 11792-9, 2013 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-24180556

RESUMO

A bioassay-directed phytochemical study was conducted to investigate potential allelochemicals in the roots of the invasive plant Ageratina adenophora. Eleven phenolic compounds, including seven new ones, 7-hydroxy-8,9-dehydrothymol 9-O-trans-ferulate (1), 7-hydroxythymol 9-O-trans-ferulate (2), 7,8-dihydroxythymol 9-O-trans-ferulate (3), 7,8-dihydroxythymol 9-O-cis-ferulate (4), methyl (7R)-3-deoxy-4,5-epoxy-D-manno-2-octulosonate 8-O-trans-p-coumarate (5), methyl (7R)-3-deoxy-4,5-epoxy-D-manno-2-octulosonate 8-O-cis-p-coumarate (6), and 3-(2-hydroxyphenyl)propyl methyl malonate (7), were isolated from a bioactive subfraction of the ethanol extract of the roots of A. adenophora. The new structures were established on the basis of detailed spectroscopic analysis. The potential phytotoxic effects of these compounds on the germination of Arabidopsis thaliana seeds were tested by a filter paper assay. Compound 7 and known compounds 3-(2-hydroxyphenyl)-1-propanol (8) and o-coumaric acid (9) remarkably showed inhibition activity against Arabidopsis seed germination at a concentration of 1.0 mM. Compounds 1, 2, 5, 6, and 10 showed slight inhibitory activity at the test concentration after treatment for 3 days, while the other compounds showed no obvious inhibitory effects. Moreover, 7-9 were further found to show obvious inhibitory activity on retarding the seedling growth of Ar. thaliana cultured in soil medium.


Assuntos
Ageratina/química , Arabidopsis/efeitos dos fármacos , Germinação/efeitos dos fármacos , Fenóis/toxicidade , Extratos Vegetais/toxicidade , Raízes de Plantas/química , Sementes/crescimento & desenvolvimento , Arabidopsis/crescimento & desenvolvimento , Estrutura Molecular , Fenóis/química , Extratos Vegetais/química , Plântula/efeitos dos fármacos , Plântula/crescimento & desenvolvimento , Sementes/efeitos dos fármacos
6.
J Asian Nat Prod Res ; 15(8): 885-90, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23768076

RESUMO

Further investigation on the whole herbs of Sinocrassula indica (Crassulaceae) led to the isolation of four new acylated flavonol bisdesmosides, sinocrassosides A13, B6, B7, and D4, together with kaempferol 3-O-ß-D-(6-O-acetyl)glucopyranosyl-7-O-α-L-rhamnopyranoside. Their structures were established by spectral and chemical methods.


Assuntos
Crassulaceae/química , Flavonóis/isolamento & purificação , Saponinas/isolamento & purificação , Acilação , Medicamentos de Ervas Chinesas , Flavonóis/química , Quempferóis/química , Quempferóis/isolamento & purificação , Estrutura Molecular , Saponinas/química
7.
J Asian Nat Prod Res ; 14(5): 503-7, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22530677

RESUMO

A new megastigmane glycoside, grasshopper ketone 3-O-primveroside (1), was isolated from the methanolic extract of the whole herbs of Sinocrassula indica (Crassulaceae). Its structure was elucidated on the basis of spectral and chemical evidence.


Assuntos
Crassulaceae/química , Cicloexanonas/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Glucosídeos/isolamento & purificação , Cetonas/isolamento & purificação , Norisoprenoides/isolamento & purificação , Cicloexanonas/química , Medicamentos de Ervas Chinesas/química , Glucosídeos/química , Cetonas/química , Estrutura Molecular , Norisoprenoides/química , Ressonância Magnética Nuclear Biomolecular
8.
Biol Pharm Bull ; 26(5): 729-32, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12736522

RESUMO

Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study.


Assuntos
4-Butirolactona/farmacologia , Annonaceae/química , Álcoois Graxos/farmacologia , Lactonas/farmacologia , Mitocôndrias Hepáticas/efeitos dos fármacos , Complexos Multienzimáticos/metabolismo , NADH NADPH Oxirredutases/metabolismo , 4-Butirolactona/análogos & derivados , 4-Butirolactona/química , Acetogeninas , Animais , Galinhas , Álcoois Graxos/química , Técnicas In Vitro , Lactonas/química , Mitocôndrias Hepáticas/enzimologia , Mitocôndrias Hepáticas/metabolismo , Rotenona/química , Rotenona/farmacologia , Relação Estrutura-Atividade
9.
Life Sci ; 70(11): 1259-69, 2002 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-11883704

RESUMO

Annonaceous acetogenins have potent antitumor effect in vitro and in vivo. Squamocin is one of the annonaceous acetogenins and has been reported to have antiproliferative effect on cancer cells. Our results from this study showed that squamocin inhibited proliferation of HL-60 cells with IC50 value of 0.17 microg/ml and induced apoptosis of HL-60 cells. Investigation of the mechanism of squamocin-induced apoptosis revealed that treatment of HL-60 cells with squamocin resulted in extensive nuclear condensation. DNA fragmentation, cleavage of the death substrate poly (ADP-ribose) polymerase (PARP) and induction of caspase-3 activity. Pretreatment of HL-60 cells with caspase-3 specific inhibitor DEVD-CHO prevented squamocin-induced DNA fragmentation, PARP cleavage and cell death. The expression levels of protein bcl-2, bax have no change in response to squamocin treatment in HL-60 cells, whereas stress-activated protein kinase (SAPK/JNK) was activated after treatment with squamocin in HL-60 cells. These results suggest that apoptosis of HL-60 cells induced by squamocin requires caspase-3 activation and is related to SAPK activation.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Caspases/metabolismo , Furanos/farmacologia , Células HL-60/efeitos dos fármacos , Lactonas/farmacologia , Caspase 3 , Inibidores de Caspase , Divisão Celular/efeitos dos fármacos , Núcleo Celular/efeitos dos fármacos , Núcleo Celular/patologia , DNA de Neoplasias/análise , Relação Dose-Resposta a Droga , Ativação Enzimática/efeitos dos fármacos , Células HL-60/enzimologia , Células HL-60/patologia , Humanos , Oligopeptídeos/farmacologia , Poli(ADP-Ribose) Polimerases/metabolismo
10.
Yao Xue Xue Bao ; 37(10): 818-20, 2002 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-12567869

RESUMO

AIM: To study the inhibition of oxygen consumption by annonaceous acetogenins (ACG) and their structure-activity relationship (SAR). METHODS: The inhibition of oxygen consumption in chicken liver cell respiration by different structural ACG was studied by using oxygen electrode technique. RESULTS: Six ACG showed potent inhibitory effects like rotenone which was a classical inhibitor of mitochondrial complex I, and was more potent than complex IV inhibitor KCN. The IC50 values of six ACG for inhibiting oxygen consumption suggested that bistetrahydrofuran (THF) ACG was 7-11 times more active than non-THF ACG, and A1-type ACG was more potent than A2-type ACG. CONCLUSION: The terminal gamma-lactone was crucial for the inhibition of oxygen consumption. The distance between THF and gamma-lactone, the hydroxyl groups in the alkyl chain, were the important factors of SAR, but the 4-OH group possibly played some negative role in the exhibit of potent activity.


Assuntos
Álcoois Graxos/farmacologia , Lactonas/farmacologia , Mitocôndrias Hepáticas/efeitos dos fármacos , Consumo de Oxigênio/efeitos dos fármacos , Acetogeninas , Animais , Annona/química , Separação Celular , Galinhas , Álcoois Graxos/química , Furanos/química , Furanos/isolamento & purificação , Furanos/farmacologia , Lactonas/química , Lactonas/isolamento & purificação , Fígado/citologia , Mitocôndrias Hepáticas/metabolismo , Plantas Medicinais/química , Sementes/química , Relação Estrutura-Atividade
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