Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 167
Filtrar
1.
Chemistry ; 2021 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-33780057

RESUMO

Manganese oxides have attracted great concern in electrochemical energy storage due to high theoretical specific capacitance and abundant valence states. The multiple valence states in the redox reactions are beneficial for enhancing the electrochemical properties. Herein, three manganese microspheres were prepared by a one-pot hydrothermal method and subsequent calcination at different temperatures using carbon spheres as templates. The trivalent manganese of Mn 2 O 3 exhibited multiple redox transitions of Mn 3+ /Mn 2+ and Mn 4+ /Mn 3+ during the intercalation/deintercalation of electrolyte ions. The possible redox reactions of Mn 2 O 3 were proposed based on the cyclic voltammetry and differential pulse voltammogram results. The Mn 2 O 3 microsphere integrated the advantages of multiple redox couples and unique structure, demonstrating a high specific capacitance and long cycling stability. The symmetric Mn 2 O 3 //Mn 2 O 3 device yielded a maximum energy density of 29.3 Wh kg -1 at 250 W kg -1 .

2.
Accid Anal Prev ; 153: 106018, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33610089

RESUMO

Although spatial and temporal correlations of crash observations have been well addressed in the literature, the interactions between them are rarely studied. This study proposes a Bayesian spatiotemporal interaction (BSTI) approach for crash frequency modeling with an integrated nested Laplace approximation (INLA) method to greatly expedite the Bayesian estimation process. Manhattan, which is the most densely populated urban area of New York City, is selected as the study area. Hexagons are used as the basic geographic units to capture crash, transportation, land use, and demo-economic data from 2013 to 2019. A series of Bayesian models with various spatiotemporal specifications are developed and compared. The BSTI model with Type II interaction, which assumes that the structured temporal random effect interacts with the unstructured spatial random effect is found to outperform the others in terms of goodness-of-fit and the ability to reduce the dependency of residuals. It is also found that the unobserved heterogeneity is mostly attributed to the spatial effects instead of temporal effects. In addition, the BSTI Type II model also yields the lowest predictive error when the last year's data are used as the test set. The proposed BSTI approach can potentially advance safety analytics by achieving high prediction accuracy and computational efficiency while maintaining its interpretability on the effects of contributing factors and the unobserved heterogeneity.

4.
Ecotoxicol Environ Saf ; 212: 111944, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33524910

RESUMO

Trace metals in street dust originate from many natural and anthropogenic sources and may directly or indirectly affect daily life and health. Here, the enrichment factor (EF), an efficient parameter to assess the contamination by trace metals, was evaluated and compared in four different zones of the urban area of Nanchang city during different seasons. Results showed that EFs of trace metals have regional seasonal variations. The EF range of Cr, Ni, Cu, Zn, As, Cd and Pb were found to be (0.76-16.38), (0.66-9.06), (1.09-169.58), (1.52-36.16), (0.44-7.17), (2.07-78.38), (0.95-20.94), respectively. These values indicate minimal to significant pollution. The EF values of Zn, Cd and Pb in street dust show very similar variations as their median and mean values of EF are higher in certain zones, and their seasonal variations are similar. The Ni and As results suggest that anthropogenic influences for these elements are not significant. The Ni may be influenced by land use type rather than point sources and As may be attributed to natural sources. The Principal Component Absolute Scores - Multivariate Linear Regression (PCAS-MLR) model was used to identify the types and contributions of trace metal sources. The main sources of trace metals in dust were found to be industrial discharges and traffic emissions. However, the percentages of their contributions have significant regional differences. The relationship between the EF of trace metals and the ecological risk index (ERI) was also investigated, and indicates that seriously polluted areas correspond to high ERI regions. The land use types and characteristics of the source jointly affects the relationship between EFs and ERI.


Assuntos
Poeira/análise , Monitoramento Ambiental , Metais/análise , China , Cidades , Poluentes Ambientais/análise , Poluição Ambiental/análise , Metais Pesados/análise , Medição de Risco , Estações do Ano , Oligoelementos/análise , Urbanização
5.
Accid Anal Prev ; 152: 105971, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33508696

RESUMO

Most existing efforts to assess safety performance require sufficient crash data, which generally takes a few years to collect and suffers from certain limitations (such as long data collection time, under-reporting issue and so on). Alternatively, the surrogate safety measure (SSMs) based approach that can assess traffic safety by capturing the more frequent "near-crash" situations have been developed, but it is criticized for the potential sampling and measurement errors. This study proposes a new safety performance measure-Risk Status (RS), by fusing crash data and SSMs. Real-world connected vehicle data collected in the Safety Pilot Model Deployment (SPMD) project in Ann Arbor, Michigan is used to extract SSMs. With RS treated as a latent variable, a structural equation model with conditional autoregressive spatial effect and corridor-level random parameters is developed to model the interrelationship among RS, crash frequency, risk identified by SSMs, and contributing factors. The modeling results confirm the proposed interrelationship and the necessity to account for both spatial autocorrelation and unobserved heterogeneity. RS can integrate both crash frequency and SSMs together while controlling for observed and unobserved factors. RS is found to be a more reliable criterion for safety assessment in an implementation case of hotspot identification.

6.
Int J Food Sci Nutr ; : 1-11, 2020 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-33043722

RESUMO

Previous randomised controlled trials have shown the controversial effectiveness of oral vitamin D supplementation in preventing osteoporotic fractures. PubMed, EMBASE and Cochrane Library electronic databases were searched. Pairwise meta-analysis, Bayesian network meta-analysis and meta-regression were applied. A total of 33 studies containing 83,083 participants were included. Oral vitamin D supplementation showed no statistically significant on reducing the risk of total fractures (RR = 0.96, 95%CI = 0.87-1.05 p = 0.389). Vitamin D3 (700-800IU/d) plus calcium showed statistical significance in reducing the incidence of total, hip and non-vertebral fractures in the pairwise meta-analysis. Significant reductions were specifically identified in female in total and hip fractures. However, we did not observe any above significant results using Bayesian network meta-analyses. Strikingly, a meta-regression analysis identified an inverse association between the efficacy of fracture prevention and increased body mass index. Thus, we recommended that the vitamin D dose should be adjusted according to BMI based on further confirmation.

7.
Drug Des Devel Ther ; 14: 3201-3214, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32982167

RESUMO

Introduction: Overexpression of c-Met, or hepatocyte growth factor (HGF) receptor, is commonly observed in tumor biopsies and often associated with poor patient survival, which makes HGF/c-Met pathway an attractive molecular target for cancer therapy. A number of antibody-based therapeutic strategies have been explored to block c-Met or HGF in cancers; however, clinical efficacy has been very limited, indicating that blockade of c-Met signal alone is not sufficient. Thus, an alternative approach is to develop an immunotherapy strategy for c-Met-overexpressing cancers. c-Met/CD3 bispecific antibody (BsAb) could bridge CD3-positive T lymphocytes and tumor cells to result in potent tumor cell killing. Materials and Methods: A bispecific antibody, BS001, which binds both c-Met and CD3, was generated using a novel BsAb platform. Western blotting and T cells-mediated killing assays were utilized to evaluate the BsAb's effects on cell proliferation, survival and signal transduction in tumor cells. Subcutaneous tumor mouse models were used to analyze the in vivo anti-tumor effects of the bispecific antibody and its combination therapy with PD-L1 antibody. Results: BS001 showed potent T-cell mediated tumor cells killing in vitro. Furthermore, BS001 inhibited phosphorylation of c-Met and downstream signal transduction in tumor cells. In A549 lung cancer xenograft model, BS001 inhibited tumor growth and increased the proportion of activated CD56+ tumor infiltrating lymphocytes. In vivo combination therapy of BS001 with Atezolizumab (an anti-programmed cell death protein1-ligand (PD-L1) antibody) showed more potent tumor inhibition than monotherapies. Similarly, in SKOV3 xenograft model, BS001 showed a significant efficacy in tumor growth inhibition and tumor recurrence was not observed in more than half of mice treated with a combination of BS001 and Pembrolizumab. Conclusion: c-Met/CD3 bispecific antibody BS001 exhibited potent anti-tumor activities in vitro and in vivo, which was achieved through two distinguished mechanisms: through antibody-mediated tumor cell killing by T cells and through inhibition of c-Met signal transduction.

8.
Artigo em Inglês | MEDLINE | ID: mdl-32813665

RESUMO

Lightweight and real-time multi-lead electrocardiogram (MECG) compression on wearable devices is important and challenging for long-term health monitoring. To make use all three kinds of correlations of MECG data simultaneouly, we construct 3-order incremental tensor and formulate data compression problem as tensor decomposition. However, the conventional tensor decomposition algorithms for large-scale tensor are usually too computationally expensive to apply to wearable devices. To reduce the computation complexity, we develop online compression approach by incrimental tracking the CANDECOMP/PARAFAC (CP) decomposition of dynamic incremental tensors, which can efficiently utilize the tensor compression result based on the previous MECG data to derive the tensor compression upon arriving of new data. We evaluate the performance of our method with the Physikalisch-Technische Bundesanstalt MECG diagnostic dataset. Our method can achieve the averaged percentage root-mean-square difference (PRD) of 8.35 2.28% and the compression ratio (CR) of 43.05 2.01, which is better than five state-of-the-art of methods. Additionally, it can also well preserve the information of R-peak. Our method is suitable for near real-time MECG compression on wearable devices.

9.
Plant Sci ; 298: 110570, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32771171

RESUMO

Seed dormancy is closely related to pre-harvest sprouting resistance. Both plant hormone abscisic acid (ABA) and DELAY OF GERMINATION 1 (DOG1) protein are key regulators of seed dormancy. Their relationship is well reported in Arabidopsis, but little is known in rice. Here, we show that a quantitative trait locus, qSd-1-1 contributes significantly to seed dormancy differences between the strongly dormant indica variety N22 and non-dormant japonica variety Nanjing35. It encodes a DOG1-like protein named OsDOG1L-3 with homology to Arabidopsis DOG1. There were evident promoter and expression differences in OsDOG1L-3 between N22 and Nanjing35, and overexpression or introduction of the N22 OsDOG1L-3 allele in Nanjing35 enhanced its seed dormancy. OsDOG1L-3 expression was positively correlated with seed dormancy and induced by ABA. OsbZIP75 and OsbZIP78 bound directly with the promoter of OsDOG1L-3 to induce its expression. Overexpression of OsbZIP75 increased OsDOG1L-3 protein abundance and promoted seed dormancy. OsDOG1L-3 upregulated expression of ABA-related genes and increased ABA content. We propose that the N22 OsDOG1L-3 allele is a candidate gene for the seed dormancy in QTL qSd-1-1, and that it participates in the ABA pathway to establish seed dormancy in rice.

10.
Proc Natl Acad Sci U S A ; 117(36): 22237-22248, 2020 09 08.
Artigo em Inglês | MEDLINE | ID: mdl-32839316

RESUMO

NOD-like receptors (NLRs) are traditionally recognized as major inflammasome components. The role of NLRs in germ cell differentiation and reproduction is not known. Here, we identified the gonad-specific Nlrp14 as a pivotal regulator in primordial germ cell-like cell (PGCLC) differentiation in vitro. Physiologically, knock out of Nlrp14 resulted in reproductive failure in both female and male mice. In adult male mice, Nlrp14 knockout (KO) inhibited differentiation of spermatogonial stem cells (SSCs) and meiosis, resulting in trapped SSCs in early stages, severe oligozoospermia, and sperm abnormality. Mechanistically, NLRP14 promoted spermatogenesis by recruiting a chaperone cofactor, BAG2, to bind with HSPA2 and form the NLRP14-HSPA2-BAG2 complex, which strongly inhibited ChIP-mediated HSPA2 polyubiquitination and promoted its nuclear translocation. Finally, loss of HSPA2 protection and BAG2 recruitment by NLRP14 was confirmed in a human nonsense germline variant associated with male sterility. Together, our data highlight a unique proteasome-mediated, noncanonical function of NLRP14 in PGCLC differentiation and spermatogenesis, providing mechanistic insights of gonad-specific NLRs in mammalian germline development.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Proteínas Reguladoras de Apoptose/metabolismo , Diferenciação Celular/fisiologia , Proteínas de Choque Térmico HSP70/metabolismo , Chaperonas Moleculares/metabolismo , Espermatogênese/genética , Transporte Ativo do Núcleo Celular/genética , Transporte Ativo do Núcleo Celular/fisiologia , Proteínas Adaptadoras de Transdução de Sinal/genética , Células-Tronco Germinativas Adultas/fisiologia , Animais , Proteínas Reguladoras de Apoptose/genética , Feminino , Deleção de Genes , Regulação da Expressão Gênica/fisiologia , Variação Genética , Células Germinativas , Proteínas de Choque Térmico HSP70/genética , Humanos , Infertilidade Masculina/genética , Masculino , Camundongos , Chaperonas Moleculares/genética , Nucleosídeo-Trifosfatase/genética , Nucleosídeo-Trifosfatase/metabolismo , Espermatogênese/fisiologia
11.
Accid Anal Prev ; 144: 105669, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32650292

RESUMO

Highway horizontal curves (H-curves) provide a smooth transition between two tangent sections of roadways. They allow vehicles to adjust their travel directions gradually. However, the geometry changes of the highway sections with H-curves often raise safety concerns. In order to deploy effective safety countermeasures, a critical task is to understand the risk factors associated with H-curves. Existing studies have made efforts to probe the safety issues associated with H-curves, whereas they were limited to relatively small-scale examinations because of the challenges in identifying H-curves from large road networks. In addition, due to the lack of well-archived traffic and roadway information, gathering other data associated with the H-curves is also difficult. Regarding to these gaps, this study aims to leverage open-source data to analyze the crash risk of highway sections with H-curves. In particular, the present study highlights itself from two main aspects: (i) a H-curve extraction tool was developed to facilitate large-scale curve data collection through the analytics of different open source data; and (ii) a crash modeling framework was developed to quantify H-curve crash risk. A case study based on a statewide road network was performed to test the developed crash risk models with the collected curve data. The results show the opportunities of using the developed tool for large-scale data collection and analyze the safety impacts of H-curve geometric properties, elevation change, traffic exposure, among others. Findings of this study provide insights into the improvement of H-curve data collection and safety evaluation.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Condução de Veículo/estatística & dados numéricos , Planejamento Ambiental/estatística & dados numéricos , Análise Espacial , Análise de Dados , Coleta de Dados , Humanos , Modelos Logísticos , Fatores de Risco , Segurança
12.
Front Oncol ; 10: 981, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32626659

RESUMO

Background: Colorectal cancer (CRC) is the result of complex interactions between the tumor's molecular profile and metabolites produced by its microenvironment. Despite recent studies identifying CRC molecular subtypes, a metabolite classification system is still lacking. We aimed to explore the distinct phenotypes and subtypes of CRC at the metabolite level. Methods: We conducted an untargeted metabolomics analysis of 51 paired tumor tissues and adjacent mucosa using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Multivariate analysis including principal component analysis, orthogonal partial least squares discriminant analysis and heat maps, univariate analysis, and pathway analysis were used to identify potential metabolite phenotypes of CRC. Unsupervised consensus clustering was used to identify robust metabolite subtypes, and evaluated their clinical relevance. Results: A total of 173 metabolites (including nucleotides, carbohydrates, free fatty acids, and choline) were identified between CRC tumor tissue and adjacent mucosa. We found that lipid metabolism was closely related to the occurrence and progression of CRC. In particular, CRC tissues could be divided into three subtypes, and statistically significant correlations between different subtypes and clinical prognosis were observed. Conclusions: CRC tumor tissue exhibits distinct metabolite phenotypes. Metabolite differences between subtypes may provide a basis and direction for further clinical individualized treatment planning.

13.
Food Funct ; 11(7): 5976-5991, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32666969

RESUMO

Non-alcoholic fatty liver disease (NAFLD) is a disease that is prevalent worldwide, and its prevention by dietary administration has recently been considered as an important strategy. In this study, we administered mice with vine tea polyphenol (VTP) extracted from Ampelopsis grossedentata, a Chinese herb, to investigate the preventive effect on western diet (WD)-induced NAFLD. Male C57BL/6N mice were fed either a normal diet (ND) or WD with or without VTP for 12 weeks. The results revealed that VTP supplementation decreased the serum levels of cholesterol and triglycerides, and reduced the accumulation of hepatic lipid droplets caused by WD. Molecular data revealed that VTP enhanced fatty acid oxidation by reactivating the WD-suppressed phosphorylation of AMP-activated protein kinaseα (AMPKα) and the expressions of peroxisome proliferator-activated receptor alpha (PPARα), carnitine palmitoyl transferase IA (CPT1A) and cytochrome P450, family 4, subfamily a1 (CYP4A1). VTP inhibited hepatic lipogenesis by reducing the WD-enhanced level of mature sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FAS). Moreover, VTP activated nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated expressions of hemeoxygenase-1 (HO-1) and quinone oxidoreductase (NQO1), and reduced hepatic TBARS levels to prevent hepatic oxidative stress. On the other hand, VTP also increased intestinal zonula occludens-1 (ZO-1) expression and the relative abundance of gut Akkermansia, and reduced the ratio of Firmicutes/Bacteroidetes. Thus, VTP might prevent WD-induced NAFLD by balancing fatty acid oxidation and lipogenesis, hepatic oxidative stress, and gut microbiome, at least. These results suggest that vine tea, containing a high content of the bioactive compound dihydromyricetin, is a potential food resource for preventing NAFLD.

14.
Onco Targets Ther ; 13: 6093-6108, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32612370

RESUMO

Purpose: Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic review and meta-analysis to identify differential metabolic biomarkers between these two types of cancers. Materials and Methods: PubMed, Embase, and ScienceDirect were searched to identify all metabolomics studies of gastric cancer and colorectal cancer published up to September 2018. Differential metabolites or altered pathways were extracted. The intersections and differences for these metabolites and pathways between gastric cancer and colorectal cancer were compared. Candidate biomarker sets for diagnosis were proposed from biofluid or feces by comparing them with tumor tissues. Results: Totally, 24 and 65 studies were included in gastric cancer and colorectal cancer, and 223 and 472 differential metabolites were extracted, respectively. Eight pathways were reproducibly enriched in blood, tissue and urine in gastric cancer, while, 11 pathways were reproducibly enriched in blood, urine, feces and tissue in colorectal cancer. Candidate metabolic biomarker sets in blood, urine, or feces for these two cancers were proposed. We found 27 pathways (categorized into eight classifications) common to both cancers, five pathways involving 35 metabolites enriched only in gastric cancer, and eight pathways involving 54 metabolites enriched only in colorectal cancer. Conclusion: The altered metabolic pathways showed signatures of abnormal metabolism in gastric cancer and colorectal cancer; the potential metabolic biomarkers proposed in this study have important implications for the prospective validation of gastric cancer and colorectal cancer.

15.
Trials ; 21(1): 586, 2020 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-32600474

RESUMO

BACKGROUND: Residual and recurrent stones remain one of the most important challenges of hepatolithiasis and are reported in 20 to 50% of patients treated for this condition. To date, the two most common surgical procedures performed for hepatolithiasis are choledochojejunostomy and T-tube drainage for biliary drainage. The goal of the present study was to evaluate the therapeutic safety and perioperative and long-term outcomes of choledochojejunostomy versus T-tube drainage for hepatolithiasis patients with sphincter of Oddi laxity (SOL). METHODS/DESIGN: In total, 210 patients who met the following eligibility criteria were included and were randomized to the choledochojejunostomy arm or T-tube drainage arm in a 1:1 ratio: (1) diagnosed with hepatolithiasis with SOL during surgery; (2) underwent foci removal, stone extraction and stricture correction during the operation; (3) provided written informed consent; (4) was willing to complete a 3-year follow-up; and (5) aged between 18 and 70 years. The primary efficacy endpoint of the trial will be the incidence of biliary complications (stone recurrence, biliary stricture, cholangitis) during the 3 years after surgery. The secondary outcomes will be the surgical, perioperative and long-term follow-up outcomes. DISCUSSION: This is a prospective, single-centre and randomized controlled two-group parallel trial designed to demonstrate which drainage method (Roux-en-Y hepaticojejunostomy or T-tube drainage) can better reduce biliary complications (stone recurrence, biliary stricture, cholangitis) in hepatolithiasis patients with SOL. TRIAL REGISTRATION: Clinical Trials.gov: NCT04218669 . Registered on 6 January 2020.

16.
J Colloid Interface Sci ; 576: 505-513, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32512403

RESUMO

The electrolyte additives of potassium ferricyanide and potassium persulfate can ensure that CoO-supercapacitors achieve a fast charge/slow discharge and long cycling stability. The redox couple of Fe(CN)63-/Fe(CN)64- can induce S2O82- to produce the sulfate radical ( [Formula: see text] ). Strong oxidizing species, including S2O82-, Fe(CN)63- and [Formula: see text] , can accelerate oxidation of the CoO electrode surface from Co2+ to Co3+ in the charge process. The additives can achieve a good synergistic effect on accelerating CoO oxidation during the charge process. In a three-electrode cell, a CoO electrode with electrolyte additives achieves a fast-charge and slow-discharge time of 939 s and 1699 s at a current density of 1 A g-1, respectively. The capacitance retention can be maintained at 84.5% after 10,000 cycles at a current density of 5 A g-1. As a supercapacitor, the device can achieve a fast-charge and slow-discharge time of 156 s and 191 s at a current density of 1 A g-1, respectively. The capacitance retention can be maintained at 85.5% after 10,000 cycles at a current density of 5 A g-1.

17.
Proc Natl Acad Sci U S A ; 117(28): 16649-16659, 2020 07 14.
Artigo em Inglês | MEDLINE | ID: mdl-32586957

RESUMO

Low availability of nitrogen (N) is often a major limiting factor to crop yield in most nutrient-poor soils. Arbuscular mycorrhizal (AM) fungi are beneficial symbionts of most land plants that enhance plant nutrient uptake, particularly of phosphate. A growing number of reports point to the substantially increased N accumulation in many mycorrhizal plants; however, the contribution of AM symbiosis to plant N nutrition and the mechanisms underlying the AM-mediated N acquisition are still in the early stages of being understood. Here, we report that inoculation with AM fungus Rhizophagus irregularis remarkably promoted rice (Oryza sativa) growth and N acquisition, and about 42% of the overall N acquired by rice roots could be delivered via the symbiotic route under N-NO3 - supply condition. Mycorrhizal colonization strongly induced expression of the putative nitrate transporter gene OsNPF4.5 in rice roots, and its orthologs ZmNPF4.5 in Zea mays and SbNPF4.5 in Sorghum bicolor OsNPF4.5 is exclusively expressed in the cells containing arbuscules and displayed a low-affinity NO3 - transport activity when expressed in Xenopus laevis oocytes. Moreover, knockout of OsNPF4.5 resulted in a 45% decrease in symbiotic N uptake and a significant reduction in arbuscule incidence when NO3 - was supplied as an N source. Based on our results, we propose that the NPF4.5 plays a key role in mycorrhizal NO3 - acquisition, a symbiotic N uptake route that might be highly conserved in gramineous species.


Assuntos
Proteínas de Transporte de Ânions/metabolismo , Glomeromycota/fisiologia , Micorrizas/fisiologia , Nitrogênio/metabolismo , Oryza/metabolismo , Proteínas de Plantas/metabolismo , Proteínas de Transporte de Ânions/genética , Regulação da Expressão Gênica de Plantas , Nitratos/metabolismo , Oryza/genética , Oryza/crescimento & desenvolvimento , Oryza/microbiologia , Proteínas de Plantas/genética , Raízes de Plantas/genética , Raízes de Plantas/crescimento & desenvolvimento , Raízes de Plantas/metabolismo , Raízes de Plantas/microbiologia , Sorghum/genética , Sorghum/metabolismo , Sorghum/microbiologia , Zea mays/genética , Zea mays/metabolismo , Zea mays/microbiologia
18.
Accid Anal Prev ; 143: 105608, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32480017

RESUMO

Dockless electric scooters (E-Scooters) have emerged as a popular micro-mobility mode for urban transportation. This new form of mobility offers riders a flexible option for massive first-/last-mile trips. Despite the popularity, the limited regulations of E-Scooters raise numerous safety concerns among the public and agencies. Due to the unavailability of well-archived crash data, it is difficult to understand and characterize current state quo of E-Scooter-involved crashes. This paper aims to shorten the gap by analyzing a set of reported crash data to describe the patterns of crashes related to E-Scooter use. Specifically, massive media reports were searched and investigated for constructing the crash dataset. Key crash elements such as rider demographics, crash type, and location were organized in an information table for analysis. From 2017 to 2019, there were 169 E-Scooter-involved crashes identified from the news reports across the country. Through the descriptive analysis and cross tabulation analysis, the distinct characteristics of these reported crashes were highlighted. Overall, there was a growing trend for the reported E-Scooter-involved crashes unevenly distributed among the States. The distribution of the crashes across different groups of users, facilities, time periods, and severity levels also showed skewed patterns toward a subset of categories. The quantitative analyses also provide some supportive evidences for warranting the discussion on key issues, including helmet use, riding under influence (RUI), vulnerable riders, and data deficiency. This study highlights the importance of public awareness and timely developing safety countermeasures to mitigate crashes involving E-Scooters.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Veículos Automotores/normas , Conjuntos de Dados como Assunto , Humanos , Meios de Comunicação de Massa , Medição de Risco
19.
Ann Surg Oncol ; 27(11): 4181-4185, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32418077

RESUMO

BACKGROUND: Laparoscopic hepatectomy has gained popularity in the management of malignant liver lesions in the past decade. Its safety and feasibility, with faster recovery and comparable long-term outcomes, have been widely published. Nonetheless, laparoscopic isolated caudate lobectomy is still rare and technically demanding. We herein present a video on laparoscopic total caudate lobectomy for caudate cholangiocarcinoma. METHODS: The patient is a 61-year-old man who presented with epigastric distending discomfort. A contrast-enhanced magnetic resonance imaging was performed, showing a 4.6 × 3.9 cm tumor in the caudate lobe adjacent to the inferior vena cava, middle hepatic vein, right hepatic vein, as well as the bifurcation of the main trunk of the portal pedicle. The carbohydrate antigen was elevated to 54.58 U/ml (normal < 37 U/ml), and his liver function was normal. With the preoperative diagnosis of intrahepatic cholangiocarcinoma, laparoscopic caudate lobectomy was contemplated. RESULTS: The operative time was 300 min. The estimated intraoperative blood loss was 180 ml. The patient was discharged on the seventh postoperative day without any complications. Histopathological examination showed a 4.2 cm cholangiocarcinoma (T2N0M0) with a negative margin. He received a course of adjuvant chemotherapy. No recurrence was noted upon follow-up at 6 months after the operation. CONCLUSIONS: Laparoscopic resection for caudate lobe is a feasible and safe procedure. An experienced hepatobiliary surgeon could perform the procedure in selected cases, even with hepatic vein invasion.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...