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1.
Eur J Med Chem ; 201: 112527, 2020 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-32563812

RESUMO

Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. On May 1, 2020, The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients. In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesivir. Furthermore, perspectives regarding the use of remdesivir for the treatment of COVID-19 are also discussed.

2.
Langmuir ; 2020 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-32486643

RESUMO

Much attention has been paid to construct photoresponsive host-guest supramolecular gels; however, red-shifting the responsive wavelength remains a formidable challenge. Here, a wholly visible-light-responsive supramolecular gel was fabricated through the host-guest interaction between a ß-cyclodextrin (ß-CD) dimer and a tetra-ortho-methoxy-substituted azobenzene (mAzo) dimer (binary gelator) in DMSO/H2O (V/V = 8/2). The minimum gelation concentration of the low-molecular-weight binary gelator was 6 wt % measured via the tube inversion method. The substituted methoxy groups shifted the responsive wavelengths of trans-mAzo and cis-mAzo to the green and blue light regions, respectively. The host-guest interaction between mAzo and ß-CD as the driving force for gelation was confirmed using the 1H-NMR and 2D 1H NOESY spectra. The supramolecular gel showed good self-supporting ability with a storage modulus higher than 104 Pa. The release of Rhodamine B loaded in the gel as a model drug could be controlled by green light irradiation. We envisioned the potential applications of the wholly visible-light-responsive supramolecular compounds ranging from biomedical materials to smart materials.

3.
Cell Mol Neurobiol ; 2020 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-32424775

RESUMO

Activation of pro-inflammatory microglia is an important mechanism of the cerebral ischemia-reperfusion (I/R)-induced neuronal injury and dysfunction. Mesenchymal stem cells (MSCs) together with their paracrine factors demonstrated curative potential in immune disorders and inflammatory diseases, as well as in ischemic diseases. However, it remains unclear whether conditioned medium from MSCs could effectively regulate the activation and polarization of microglia exposed to I/R stimulation. In this study, we investigated the effects of conditioned medium from bone marrow MSCs (BMSCs-CM) on I/R-stimulated microglia and the potential mechanism involved, as well as the way to obtain more effective BMSCs-CM. First, cell model of oxygen-glucose deprivation/reoxygenation (OGD/R) was established in microglia to mimic the I/R. BMSCs-CM from different culture conditions (normoxic: 21% O2; hypoxic: 1% O2; hypoxia preconditioning: preconditioning with 1% O2 for 24 h) was used to treat the microglia. Our results showed that BMSCs-CM effectively promoted the survival and alleviated the injury of microglia. Moreover, in microglia exposed to OGD/R, BMSCs-CM inhibited significantly the expression of pro-inflammatory cytokines (TNF-α, IL-1ß, and IL-6), CD86 and inducible nitric oxide synthase, whereas upregulated the levels of anti-inflammatory cytokine (IL-10), CD206 and Arginase-1. These results suggested that BMSCs-CM promoted the polarization of anti-inflammatory microglia. In particular, BMSCs-CM from cultures with hypoxia preconditioning was more effective in alleviating cell injury and promoting anti-inflammatory microglia polarization than BMSCs-CM from normoxic cultures and from hypoxic cultures. Furthermore, inhibition of exosomes secretion could largely mitigate these effects of BMSCs-CM. In conclusion, our results suggested that hypoxia preconditioning of BMSCs could enhance the efficacy of BMSCs-CM in alleviating OGD/R-induced injury and in promoting the anti-inflammatory polarization of microglia, and these beneficial effects of BMSCs-CM owed substantially to exosomes.

4.
J Am Chem Soc ; 2020 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-32160466

RESUMO

Design and construction of new functionalized supramolecular coordination complexes (SCCs) via coordination-driven self-assembly strategy is highly important in supramolecular chemistry and materials science. Herein, we present a family of well-defined metallacycles decorated with mesogenic forklike dendrons through the strategy of coordination-driven self-assembly. Due to the existence of mesogenic forklike dendrons, the obtained metallacycles displayed the smectic A liquid crystal phase at room temperature while their precursors exhibited the rectangular columnar liquid crystal phase. Interestingly, by taking advantage of the electrostatic interactions between the positively charged metallacycle and the negatively charged heparin, the doping of heparin induced a significant change of the liquid-crystalline behaviors of metallacycles. More importantly, the prepared liquid-crystalline metallacycles could be further applied for holographic storage of colored images. Notably, the rhomboidal metallacycle and hexagonal metallacycle gave rise to different holographic performances although they featured a similar liquid crystal phase behavior. Therefore, this research not only provides the first successful example of supramolecular liquid-crystalline metallacycles for holographic storage of colored images but also opens a new door for supramolecular liquid-crystalline metallacycles toward advanced optical applications.

5.
Mol Med Rep ; 21(5): 2251-2259, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32186776

RESUMO

Angiogenesis plays an important role in the development and metastasis of tumors, and anti-angiogenesis agents are used to treat tumors. For example, the acute promyelocytic leukemia (APL) may be treated with arsenic trioxide. Angiogenesis in APL is a multi­step dynamic equilibrium process coordinated by various angiogenic stimulators and inhibitors, which play key roles in the occurrence, progression and chemosensitivity of this disease. Our research group previously synthesized 7­difluoromethyl­5,4'­dimethoxygenistein (DFMG), and found that it inhibits angiogenesis during atherosclerotic plaque formation. In the present study, the effect and mechanism of DFMG in angiogenesis induced by APL HL­60 cells was investigated using a chick embryo chorioallantoic membrane model and Matrigel tubule formation assays. The results obtained revealed an anti­angiogenesis effect of DFMG towards HL­60 cells. When the Toll­like receptor 4/nuclear factor­κB (TLR4/NF­κB) signaling pathway was inhibited, the anti­angiogenic effect of DFMG was further enhanced. However, when the TLR4/NF­κB signaling pathway was activated, the anti­angiogenic effect of DFMG was attenuated. These results demonstrated that DFMG inhibits angiogenesis induced by APL HL­60 cells, and provides insights into the mechanism by which DFMG inhibits the TLR4/NF­κB signaling pathway. In conclusion, in the present study, the anti­angiogenesis effect of DFMG on APL has been reported, and the mechanism by which DFMG induced the anti­angiogenesis effect was explored. These findings have provided a potential new drug candidate for the treatment of patients with APL.

6.
Artigo em Inglês | MEDLINE | ID: mdl-32017360

RESUMO

A strategy that uses carbon monoxide (CO) as a molecular trigger to switch the polymerization mechanism of a cobalt Salen complex [salen=(R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine] from ring-opening copolymerization (ROCOP) of epoxides/anhydrides to organometallic mediated controlled radical polymerization (OMRP) of acrylates is described. The key phenomenon is a rapid and quantitative insertion of CO into the Co-O bond, allowing for in situ transformation of the ROCOP active species (Salen)CoIII -OR into the OMRP photoinitiator (Salen)CoIII -CO2 R. The proposed mechanism, which involves CO coordination to (Salen)CoIII -OR and subsequent intramolecular rearrangement via migratory insertion has been rationalized by DFT calculations. Regulated by both CO and visible light, on-demand sequence control can be achieved for the one-pot synthesis of polyester-b-polyacrylate diblock copolymers (D<1.15).

7.
Artigo em Inglês | MEDLINE | ID: mdl-31943606

RESUMO

Patterning multiple images within a single element without crosstalk can significantly increase the information capacity and security, but it is challenging to enable the response capability in each image. Now, the patterning of crosstalk-free yet cooperative-thermoresponse images (holographic and fluorescent images) is successfully achieved by designing a liquid crystal (LC)/AIEgen system with a unique synergy. The AIEgen's fluorescence intensity is controlled by the LC, while the LC's phase transition is in turn promoted by the AIEgen. The fluorescent image contrast is significantly boosted by efficient energy transfer (ΦET : 96 %) from the LC to the AIEgen. The AIEgen's photocyclization for fluorescent patterning occurs in a zero-order kinetic manner and can be completed within several minutes when assisted by the LC. The photocyclization conversion is quantitatively dependent on the aggregation size: α∼exp(-d), and able to reach as high as 98 %.

8.
Graefes Arch Clin Exp Ophthalmol ; 258(3): 577-585, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31811363

RESUMO

PURPOSE: To develop a deep learning (DL) model for automated detection of glaucoma and to compare diagnostic capability against hand-craft features (HCFs) based on spectral domain optical coherence tomography (SD-OCT) peripapillary retinal nerve fiber layer (pRNFL) images. METHODS: A DL model with pre-trained convolutional neural network (CNN) based was trained using a retrospective training set of 1501 pRNFL OCT images, which included 690 images from 153 glaucoma patients and 811 images from 394 normal subjects. The DL model was further tested in an independent test set of 50 images from 50 glaucoma patients and 52 images from 52 normal subjects. A customized software was used to extract and measure HCFs including pRNFL thickness in average and four different sectors. Area under the receiver operator characteristics (AROC) curves was calculated to compare the diagnostic capability between DL model and hand-crafted pRNFL parameters. RESULTS: In this study, the DL model achieved an AROC of 0.99 [CI: 0.97 to 1.00] which was significantly larger than the AROC values of all other HCFs (AROCs 0.661 with 95% CI 0.549 to 0.772 for temporal sector, AROCs 0.696 with 95% CI 0.549 to 0.799 for nasal sector, AROCs 0.913 with 95% CI 0.855 to 0.970 for superior sector, AROCs 0.938 with 95% CI 0.894 to 0.982 for inferior sector, and AROCs 0.895 with 95% CI 0.832 to 0.957 for average). CONCLUSION: Our study demonstrated that DL models based on pre-trained CNN are capable of identifying glaucoma with high sensitivity and specificity based on SD-OCT pRNFL images.

9.
Soft Matter ; 15(31): 6411-6417, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31334529

RESUMO

Photoresponsive supramolecular gels have aroused continuous attention because of their extensive applications; however, most studies utilize UV light, which inevitably brings about some health and environmental issues. The halogen bond is an important driving force for constructing supramolecules due to its high directionality, tunable strength, good hydrophobicity, and large size of the halogen atoms. Yet, it still remains a formidable challenge to utilize halogen bonds as a driving force to fabricate a visible light responsive gel. In this work, to fabricate such a gel, azopyridine-containing Azopy-Cn (n = 8, 10, 12) was selected as a halogen bond acceptor, while 1,2-bis(2,3,5,6-tetrafluoro-4-iodophenyl)diazene (BTFIPD) was chosen as both the halogen bond donor and visible light responsive moiety. The visible light response of BTFIPD resulted from the significant separation of n-π* energy levels between trans and cis isomers due to the introduction of an electron-withdrawing group (fluorine) to azobenzene at the ortho-position. Interestingly, the gel exhibited a good gel-to-sol transition behavior upon green light irradiation. At the same time, the morphologies varied from uniform narrow flakes to broad sheets with increasing illumination time. We provide an environmentally-friendly visible light-triggered method to regulate the phase transition of supramolecular materials in applications ranging from energy conversion to information storage.

10.
ACS Appl Mater Interfaces ; 11(32): 29305-29311, 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31322855

RESUMO

We report a facile inking strategy for visual information storage (e.g., writing, printing, and beyond) via surface modification of substrates with polyphenols and subsequent in situ formation of metal-phenolic networks (MPNs) on the substrates. The reported technique has several advantages compared with current printing techniques. Diverse substrates can be used to fulfill the requirements for different applications (e.g., printing, writing, painting, and stamping). A range of colors (e.g., yellow, blue, and green) can be realized using different polyphenols (e.g., tannic acid, gallic acid, and pyrogallol) and metal ions (e.g., CuII, FeIII, and TiIV). The disadvantages (e.g., ink precipitation, color fading) associated with writing or printing using traditional ink can be overcome. The obtained paintings can be easily removed by acids enabling the recycling of substrates. The reported strategy provides a new avenue for the development of portable, nontoxic, and green technologies for writing, printing, and beyond, which expands the applications of MPN-based materials.

11.
Angew Chem Int Ed Engl ; 58(40): 14311-14318, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31282122

RESUMO

Switchable polymerization provides the opportunity to regulate polymer sequence and structure in a one-pot process from mixtures of monomers. Herein we report the use of O2 as an external stimulus to switch the polymerization mechanism from the radical polymerization of vinyl monomers mediated by (Salen)CoIII -R [Salen=N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine; R=alkyl] to the ring-opening copolymerization (ROCOP) of CO2 /epoxides. Critical to this process is unprecedented monooxygen insertion into the Co-C bond, as rationalized by DFT calculations, leading to the formation of (Salen)CoIII -O-R as an active species to initiate ROCOP. Diblock poly(vinyl acetate)-b-polycarbonate could be obtained by ROCOP of CO2 /epoxides with preactivation of (Salen)Co end-capped poly(vinyl acetate). Furthermore, a poly(vinyl acetate)-b-poly(methyl acrylate)-b-polycarbonate triblock copolymer was successfully synthesized by a (Salen)cobalt-mediated sequential polymerization with an O2 -triggered switch in a one-pot process.

12.
Adv Sci (Weinh) ; 6(10): 1900205, 2019 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-31131205

RESUMO

A new polymer electrolyte based on holographic photopolymer is designed and fabricated. Ethylene carbonate (EC) and propylene carbonate (PC) are introduced as the photoinert substances. Upon laser-interference-pattern illumination, photopolymerization occurs within the constructive regions which subsequently results in a phase separation between the photogenerated polymer and unreacted EC-PC, affording holographic photopolymer electrolytes (HPEs) with a pitch of ≈740 nm. Interestingly, both diffraction efficiency and ionic conductivity increase with an augmentation of the EC-PC content. With 50 wt% of EC-PC, the diffraction efficiency and ionic conductivity are ≈60% and 2.13 × 10-4 S cm-1 at 30 °C, respectively, which are 60 times and 5 orders of magnitude larger than the electrolyte without EC-PC. Notably, the HPEs afford better anisotropy and more stable electrochemical properties when incorporating N,N-dimethylacrylamide. The HPEs exhibit good toughness under bending, excellent optical transparency under ambient conditions, and astonishing capabilities of reconstructing colored images. The HPEs here open a door to design flexible and transparent electronics with good mechanical, electrical, and optical functions.

13.
ACS Appl Mater Interfaces ; 11(21): 19541-19553, 2019 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-31059220

RESUMO

Four-dimensional (4D) printable light-powered materials have emerged as a new generation of materials for the development of functional devices. The design of these types of materials is mostly based on the trans-cis transformation of azobenzene moieties in a liquid crystalline elastomer (LCE) matrix, in which the motion is triggered by ultraviolet (UV) irradiation. In this paper, we first report on a direct laser printable photoresist for producing light-powered 4D structures with enhanced mechanical properties and near-infrared (NIR) responsive mechanical deformation. The reported nanocomposite design is based on the photothermal effects of gold nanorods (AuNRs), which can induce the nematic-to-isotropic transition of LCE upon exposure to NIR irradiation. The miscibility between AuNRs and LCE is enhanced by thiol functionalization. Appropriate printing parameters are determined, and nanocomposites containing 0-3 wt % of AuNR loading are fabricated via femtosecond two-photon direct laser writing. The effects of the AuNR loading fraction and laser power on the light-powered actuating performance are evaluated. It is found that the nanocomposite with AuNR loading of 3 wt % demonstrates the maximum percentage (20%) of elongation under an NIR laser power of 2 W. An increase in laser power can lead to faster deformation but slower restoration. The nanocomposites demonstrate relatively good stability. Even after 300 actuation cycles, 80% of the elongation magnitude can be retained. In addition, an improvement of 80% in the complex modulus of the nanocomposites, due to the inclusion of AuNRs, is observed.

14.
J Cell Physiol ; 234(10): 18906-18916, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30953350

RESUMO

Bone marrow mesenchymal stem cells (BMSC) can ameliorate ischemic injury of various tissues. However, the molecular mechanisms involved remain to be clarified. In this study, we intend to investigate the effects of BMSC-derived conditioned medium (BMSC-CM) on hypoxia/reoxygenation (H/R)-induced injury of H9c2 myocardial cells, and the potential mechanisms. Cell injury was determined through level of cell viability, lactate dehydrogenase (LDH) release, total intracellular reactive oxygen species (ROS), mitochondrial membrane potential (Δψm), and cell apoptosis. Autophagic activity of cells was detected through levels of the autophagy-associated proteins and autophagic flux. Results showed that BMSC-CM alleviated H/R-induced injury in H9c2 cells, as demonstrated by increased cell viability and Δψm, decreased ROS production, LDH release, and cell apoptosis. Furthermore, the H/R treatment induced a decrease in autophagic activity and an increase in Notch2 signaling activation in H9c2 cells. In the presence of BMSC-CM, the autophagic activity impaired by the H/R treatment was upregulated with decreased phosphorylation of mTOR, and the activation of Notch2 signaling was downregulated. These effects of BMSC-CM could be replicated by Notch signaling inhibitor. In contrast, inhibitors of cell autophagy including chloroquine (CQ) and 3-methyladenine, diminished the protective effects of BMSC-CM. Taken together results, our study showed that BMSC-CM could protect H9c2 cells from H/R-induced injury potentially through regulating Notch2/mTOR/autophagy signaling. These findings may provide a novel insight into the mechanisms of BMSC-CM in therapy of myocardial ischemia/reperfusion injury as well as other ischemic diseases.

15.
Macromol Rapid Commun ; 40(11): e1900037, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30919508

RESUMO

Photoresponsive cholesteric liquid crystals (CLCs) are able to selectively reflect colors upon light exposure. Yet, it still remains a formidable challenge to realize simultaneous rewriting and long-life color in CLCs using visible light. Herein, guided by time dependent density functional theory (TD-DFT) computation, an octafluorinated binaphthyl azobenzene is synthesized to achieve the fast response and long-life color upon visible light exposure. Subsequently, based on the solubility parameter, uniform CLCs are formulated through a facile co-doping strategy. Interestingly, the CLCs change reflection colors from blue to green, red, and then into the near infrared region in seconds upon 550 nm light illumination. The completely reversible process is readily accessable upon 450 nm irradiation. More importantly, each color is independently stable for ≈24 h in the dark.


Assuntos
Cor , Luz , Cristais Líquidos/química , Compostos Azo/química
16.
ACS Appl Mater Interfaces ; 11(8): 8612-8624, 2019 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-30714369

RESUMO

Liquid crystalline nanocolloids (LCNCs), which are nanostructured composites comprising nanoparticles (NPs) and a liquid crystal (LC) host, have attracted a great deal of attention because of their promising new fundamental physical behaviors and functional properties. Yet, it still remains a big challenge to pattern LCNCs into mesoscale-ordered structures due to the limited NP loading in the LC host. Here, we demonstrate LCNCs in the nematic phase with a high NP loading (∼42 wt %) by in situ co-functionalizing the NP with alkyl and mesogenic ligands. The LCNCs can be assembled into ordered structures through holographic photopolymerization-induced phase separation, giving rise to holographic polymer-dispersed nematic nanocolloids (HPDNNC). Interestingly, high diffraction efficiency, low light-scattering loss, and unique electric-switchable capability are realized in the HPDNNC. In addition, high-quality switchable and unclonable colored images are reconstructed, promising a host of advanced applications (e.g., anticounterfeiting). Our findings pave a way to advance the fundamental understanding of nanostructured LCs and their practical utility in enabling a new breed of inorganic-organic composite materials.

17.
Macromol Rapid Commun ; 40(3): e1800629, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30350445

RESUMO

Photoresponsive supramolecular gels with various applications are being constantly pursued; however, achieving well-defined morphology changes of gels via light irradiation remains a formidable challenge. In this study, a gel is prepared through halogen bond between azopyridine-containing Azopy-C10 and 1,4-tetrafluorodiiodobenzene. The gel exhibits gel-sol transition due to trans-cis isomerization of the azopyridine moiety upon UV irradiation. During this transition, the morphologies vary from flake to fluffy bobble-like and finally to peony-like with increasing exposure time, which is difficult to achieve in traditional assembly systems. The microstructure change is attributed to the variations of cis-isomer content and halogen-bonding strength. The supramolecular gel provides a novel method to achieve photomodulated morphologies and broadens the applications of such kind of materials, ranging from information storage to high-tech anticounterfeit.


Assuntos
Géis/química , Halogênios/química , Transição de Fase/efeitos da radiação , Processos Fotoquímicos , Compostos Azo/síntese química , Compostos Azo/química , Derivados de Benzeno/química , Hidrocarbonetos Halogenados/química , Microscopia Eletrônica de Varredura , Modelos Químicos , Estrutura Molecular , Piridinas/química , Difração de Raios X
18.
ACS Appl Mater Interfaces ; 11(1): 1587-1594, 2019 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-30540166

RESUMO

Few-layer black phosphorus (BP) has recently emerged as a promising two-dimensional (2D) material for electronic and optoelectronic devices because of its high mobility and tunable band gap. However, BP is known to quickly degrade and oxidize in ambient conditions by breaking of the P-P bonds. As a result, there is a growing need to encapsulate BP that avoids oxygen and water while retaining the high electric performance of the devices. Here, we demonstrate a hydrophobic polymer encapsulation technique with improved thermal conductivity for high current density, which preserves the electrical properties of BP back-gate transistors compared to the commonly used Al2O3 encapsulation with improved mobility and minimal traps. The on-off ratio increases by more than an order of magnitude at room temperature and more than 4 orders of magnitude at cryogenic temperatures. High field transport shows the first systematic study on unprecedented breakdown characteristics up to -5.5 V for the 0.16 µm transistors with a high current of 1.2 mA/µm at 20 K. These discoveries open up a new way to achieve high-performance 2D semiconductors with significantly improved breakdown voltage, on-off ratios, and stability under ambient conditions for practical applications in electronic and optoelectronic devices.

19.
Chemistry ; 24(72): 19200-19207, 2018 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-30397966

RESUMO

A novel polymer electrolyte with mechanically robust and self-healing properties was fabricated through a dual-network structure, crosslinked by quadruple hydrogen bonding and chemical bonding. The dynamic ureido-pyrimidinone (UPy) dimers were the first network in the polymer matrix. This group endows the polymer electrolyte with good self-healing capacity and improves the reliability and lifetime of the polymer lithium batteries. The crosslinked polyethylene glycol-bis-carbamate dimethacrylate (PEGBCDMA) is the second network and guarantees dimensional stability and good mechanical properties of the polymer electrolyte. The dual-network self-healing polymer electrolyte (DN-SHPE) exhibits improved ionic conductivity versus the polymer electrolyte fabricated by poly(ethylene glycol) diacrylate (PEGDA). It has high thermal stability (up to 350 °C) and excellent interfacial stability with the electrodes. When the DN-SHPE-based cells were fabricated with LiFePO4 and Li metal, the resulting cells show good reversible specific capacity and considerable rate capability. Moreover, the pouch cell could maintain electrochemical function even under deformation or folding conditions.

20.
ACS Appl Mater Interfaces ; 10(49): 43184-43191, 2018 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-30421604

RESUMO

Self-supporting liquid crystalline physical gels with facile electro-optic response are highly desirable, but their development is challenging because both the storage modulus and driving voltage increase simultaneously with gelator loading. Herein, we report liquid crystalline physical gels with high modulus but low driving voltage. This behavior is enabled by chirality transfer from the molecular level to three-dimensional fibrous networks during the self-assembly of 1,4-benzenedicarboxamide phenylalanine derivatives. Interestingly, the critical gel concentration is as low as 0.1 wt %. Our findings open doors to understanding and exploiting the role of chirality in organic gels.

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