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2.
Front Aging Neurosci ; 13: 748637, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34720997

RESUMO

Emerging evidence suggests that anesthesia and surgery may induce gut dysbiosis. Gut dysbiosis leads to imbalance in circulating contents of microbiota-derived metabolites and disrupts the integrity of the blood-brain barrier (BBB), contributing to postoperative cognitive dysfunction (POCD). The composition of gut microbiota may be influenced by various antibiotics. However, how perioperative use of antibiotics affects POCD needs more explorations. In the present study, we explored the effect of cefazolin, a common antibiotic used in perioperative period, on cognitive function, BBB integrity, gut bacteria and short chain fatty acids (SCFAs), a group of widely studied metabolites in aged mice, using 18-month-old male mice. Significant BBB disruptions and decreased levels of tight junction proteins, zonula occludens-1 (ZO-1) and Occludin (OCLN) were seen in the mice of POCD model. Cefazolin treatment attenuated these changes induced by anesthesia and surgery. Furthermore, cefazolin reversed the changes in several fecal bacteria (ß-, γ/δ-, ε-Proteobacteria, and Bacteroidetes) as determined by qPCR tests. Analysis of plasma SCFAs showed that almost all types of SCFAs were reduced in POCD and cefazolin administration reversed the changes in expression of the two most abundant SCFAs (acetic and propionic acids). In conclusion, this study demonstrated that cefazolin improved POCD. Mechanistically, cefazolin suppressed the disruption of BBB, gut microbiota or SCFAs, thereby ameliorating POCD.

3.
Small ; : e2105273, 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34741428

RESUMO

Nanomaterials usually manifest unique properties in solutions but will be undermined in the solid state. It is necessary to incorporate them into substrates or hybrid them with other functional materials for multiple devices and applications. Though there are a variety of methods to inherit their intrinsic properties like fluorescent and mechanical performance, most nanohybrid materials would lose their transparency irreversibly when construct solid-state devices. As a hot topic of nanomaterials in recent years, scientific works found a type of carbon dots using silane coupling agents as precursors that can overcome the shortcoming. These carbon dots, called silane-functionalized carbon dots (SiCDs), are catching increasing interest due to their versatility. Silane coupling agents endow SiCDs with the ability to disperse in solvents or polymerize with matrices by blending or covalent bonds without loss of transparency and decline of performance. The distinguishing features make SiCDs an ideal high transmittance, high doping concentration nanomaterial. The synergistic effect of SiCDs and hybridized sol-gel solid structures can not only hold the optical features of CDs but also enhance their original physical and chemical performance. This highlight focuses on the connection between SiCDs and organosilanes. Plus, preparation methods, applications, and prospective of SiCDs are mentioned.

4.
Transl Vis Sci Technol ; 10(13): 30, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34817575

RESUMO

Purpose: To investigate the effects of indocyanine green (ICG) solution on the viability and cytolysis of human lens epithelial cells ex vivo. Methods: A total of 200 pieces of anterior capsules were obtained during cataract surgery, and 110 pieces of the anterior capsules were randomly divided into five groups and treated by immersion in different concentrations of ICG solution. The remaining 90 anterior capsules were also divided into five groups and treated with a combination of drug immersion and washing in balanced salt solution. Electron microscopy and trypan blue and eosin stains were used to analyze the cells. Percentage of dead, shedding, or living lens epithelial cells was estimated and used to demonstrate effects of the ICG on viability and cytolysis. Results: Compared with the control group, the percentage of dead and shedding lens epithelial cells increased while the percentage of living lens epithelial cells decreased in all the immersion groups. In the washing groups, the percentage of the living lens epithelial cells was 63.42% ± 2.49%, 54.04% ± 1.84%, 43.51% ± 2.63%, 29.21% ± 2.40%, and 15.73% ± 1.61% for the five groups and reflected a concentration-effect relationship. Electron microscopy showed that the higher the concentration of the ICG solution, the more severe the destruction of the lens epithelial cell structure. Conclusions: ICG could reduce the viability of the lens epithelial cells and promote cell cytolysis. Translational Relevance: Our study showed that ICG could directly reduce the viability of the lens epithelial cells in a concentration-dependent fashion, which can theoretically reduce the incidence of posterior capsule opacification.

5.
Soft Matter ; 17(39): 8769-8785, 2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34604877

RESUMO

Three-dimensional (3D) bioprinting has rapidly developed in the last decade, playing an increasingly important role in applications including pharmacokinetics research, tissue engineering, and organ regeneration. As a cutting-edge technology in 3D printing, gel bath-supported 3D bioprinting enables the freeform construction of complex structures with soft and water-containing materials, facilitating the in vitro fabrication of live tissue or organ models. To realize in vivo-like organs or tissues in terms of biological functions and complex structures by 3D printing, high resolution and fidelity are prerequisites. Although a wide range of gel matrices have recently been developed as supporting materials, the effect of bath properties and printing parameters on the print resolution is still not clearly understood. This review systematically introduces the decisive factors for resolution in both bulk gel bath systems and granular microgel bath systems, providing guidelines for high-resolution 3D bioprinting based on bath properties and printing parameters.


Assuntos
Bioimpressão , Microgéis , Banhos , Impressão Tridimensional , Engenharia Tecidual , Tecidos Suporte
7.
Dalton Trans ; 50(39): 13661-13665, 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34591058

RESUMO

A sextuple-decker heteroleptic phthalocyanine heterometallic compound (1) with a subunit arrangement of {(Pc)Sm(Pc)Cd(Pc*)Cd(Pc*)Cd(Pc)Sm(Pc)} has been prepared and analyzed using various spectroscopic instruments, in which four unsubstituted phthalocyanine anions (Pc) and two substituted analogues (Pc*) with n-pentoxyl substituents at eight peripheral positions are connected through the complexation of two Sm(III) and three Cd(II) ions. In particular, its sextuple-decker structure has been disclosed by the single-crystal X-ray diffraction technique. The solution and gel glass forms of this compound display third-order nonlinear optical properties due to the intrinsic conjugated nature over the sextuple-decker sandwich complex.

8.
Nat Sci Sleep ; 13: 1395-1410, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34393534

RESUMO

Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND.

9.
Nanomaterials (Basel) ; 11(7)2021 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-34361149

RESUMO

The absence of an ideal solid matrix with resistance to harsh conditions for carbon dots (CDs) and high transmittance in the visible/near infrared region is the bottleneck in CD applications. In this study, we show that a stable rigid structure can be formed between CDs and organically modified silicates (ormosil) gel when CDs are incorporated into ormosil gel hybrids as a solid matrix. A high photoluminescence quantum yield (PLQY) of 63% is achieved at a 583 nm emission. Peak optical gain of the hybrids was found to be 67 cm-1 at peak wavelength. Ultralow threshold (~70 W/cm2) lasing can also be demonstrated from a planar microcavity by using CD-ormosil gel hybrids as a gain medium.

10.
Int J Biol Macromol ; 186: 206-217, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34246671

RESUMO

Phycocyanin (PC) is considered to be an effective natural photosensitizer, but it has not been well utilized as its inefficient biostability and intracellular accumulation. To overcome these limitations, the nano-sized PC particles (LAPC/DOX) were developed by grafting with lactobionic acid (LA) and loading with doxorubicin (DOX). Compared to the PC solution, the storage-stability and photostability of PC particles were remarkably increased, and the formation of nanoparticles further improved its biostability. Besides, CLSM images confirmed that LA could also enhance cellular uptake, resulting in more intracellular PC and DOX accumulation. MTT assay revealed that LAPC/DOX caused the highest cytotoxicity by combined chemo-photodynamic therapy. Finally, LAPC/DOX could efficiently accumulate and spread in tumoral multicellular spheroids, resulting in the enhanced growth inhibition. Overall, the LAPC/DOX is effective in cancer treatment, which provides new insights for the usage of functional proteins in vivo.

11.
Phys Chem Chem Phys ; 23(27): 14725-14736, 2021 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-34190242

RESUMO

In order to reveal the correlation effect on the electronic properties in particular 5f electron occupation numbers of Pu/U ions in a (Pu,U) mixed oxide-PuUO4, a first principles calculation is performed by using density functional theory (DFT) plus a dynamical mean field theory (DMFT) scheme with the spin-orbit coupling (SOC) and on-site Coulomb repulsion for correlation effect due to localized Pu/U 5f orbitals. Results demonstrate that Pu/U 5f electron occupation numbers in the ground state of PuUO4 are mainly composed of 5f4/5f5 and 5f2/5f3 configurations, and exhibiting the intermediate occupation (IO) numbers with average 5f occupation numbers of about nf = 4.879 and 2.423 for Pu and U ions, respectively, irrespective of different Pu and U lattice sites in PuUO4. Pu 5f j = 5/2 and j = 7/2 components are in moderately and weakly correlated states, respectively, while U 5f j = 5/2 and j = 7/2 manifolds are both in weakly correlated states. jj and LS coupling schemes are feasible for Pu and U 5f electrons, respectively. In order to directly compare with the experimental angle-resolved photoemission spectrum (ARPES), we also estimate the momentum-resolved electronic spectrum function for this system.

12.
J Clin Virol ; 141: 104880, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34153861

RESUMO

BACKGROUND: Enterovirus D68 (EV-D68) is an emerging pathogen in humans. EV-D68 causes a wide range of respiratory symptoms in children and has the propensity to cause severe complications. EV-D68 outbreaks are rarely investigated in mainland China. Therefore, in this study, we aimed to investigate the prevalence of EV-D68 in children and to describe the clinical manifestations as well as the phylogeny of EV-D68 in Guangdong Province from 2014 to 2018. METHODS: Nasopharyngeal swabs were collected from hospitalized children with respiratory symptoms and screened for respiratory pathogens by fluorescence quantitative PCR and culture. The EV-positive samples were subsequently typed by sequencing the 5'-untranslated region and EV-D68-specific VP1 capsid gene. A phylogenetic tree was constructed by the maximum-likelihood method based on the VP1 gene using ClustalW. RESULTS: A total of 1,498 (59.8%) out of 2,503 children were screened positive for ≥1 virus species. Among the 158 (6.31%) EV-positive samples, 17 (0.68%) were identified as EV-D68. Most EV-D68 cases (n = 14) were diagnosed with pneumonia and bronchial pneumonia. No deaths were found in EV-D68 cases. Wheezing occurred in EV-D68 cases more frequently (70.59% vs. 43.26%, P = 0.040) than that of other EVs. All the EV-D68 were of clade B3, which were highly similar to the strains circulating in China. CONCLUSION: EV-D68 was the predominant enterovirus type in hospitalized children with respiratory symptoms in Guangdong Province. All the EV-D68 strains belong to clade B3. The development of diagnostic tools is warranted in order to monitor EV-D68 infections in China.


Assuntos
Enterovirus Humano D , Infecções por Enterovirus , Infecções Respiratórias , Criança , Criança Hospitalizada , Surtos de Doenças , Enterovirus Humano D/genética , Infecções por Enterovirus/epidemiologia , Humanos , Lactente , Epidemiologia Molecular , Filogenia , Infecções Respiratórias/epidemiologia
13.
Biotechnol Lett ; 43(8): 1675-1684, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34014413

RESUMO

Wound exudate holds great clinical and research potential in wound repair via paracrine signaling. In essence, exudate is modified serum that contains a high concentration of exosomes. The aim of this study was to investigate the role of serum-derived exosomes in scald wound healing of NIH mice skin and to explore the underlying mechanisms. Hence, we constructed a deep second-degree scald model in NIH mice, testing the benefits of exosomes in the scald wound healing. The scratch wound assay, apoptosis assay and MTT assay were conducted to assess the effects of serum-derived exosomes on migration, apoptosis and proliferation of HaCaT cells and fibroblasts. Our results showed that serum-derived exosomes injected subcutaneously entered cells and effectively accelerated wound healing processes in mice. Additionally, serum-derived exosomes optimized functions of cells related to skin injury repair by stimulating fibroblast proliferation, promoting HaCaT cell migration, and suppressing apoptosis of HaCaT cells induced by heat stress. Further study revealed that serum-derived exosomes enhanced phosphorylation of the serine-threonine kinase Akt in scalded skin tissue. These results suggest a potential clinical use of serum-derived exosomes for treating skin scald.

14.
BMC Ophthalmol ; 21(1): 222, 2021 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-34001069

RESUMO

BACKGROUND: Ocular toxoplasmosis caused by Toxoplasma gondii is an infectious disease which is widely distributed around the world and can present with various clinic manifestations. We are here reporting an unusual case presented with epiretinal membrane (ERM), i.e., macular pucker. CASE PRESENTATION: A 16-year old male patient visited our outpatient clinic complaining of decreased vision for about 8 years in his left eye. The best-corrected visual acuity (BCVA) was 20/20 OD and 20/400 OS. There was sensory exotropia in his left eye. No inflammatory cells or flare were found in his anterior chamber or vitreous cavity OU. An ERM involving his left macular area was found on his dilated fundus exam, which was confirmed by Optical Coherence Tomography (OCT). The ERM was found to involve his left macular area with his foveal ellipsoid zone absent. The right eye was found to be within normal limit. After a thorough discussion with the patient and his parents about treatment options and surgical benefits, risks and alternatives, we performed vitrectomy, peeled off the ERM and collected the vitreous sample for parasite testing during the procedure. Patient's blood also was drawn for serological testing. Vitreous sample analysis and serological tests confirmed ocular toxoplasmosis OS as his final diagnosis. Unfortunately, the BCVA of this patient was not improved after the surgery, but the exotropia disappeared. CONCLUSION: ERM is an unusual clinical presentation of ocular toxoplasmosis. We may add Toxoplasma gondii infection as a differential diagnosis when encountering ERM cases.


Assuntos
Membrana Epirretiniana , Toxoplasmose Ocular , Adolescente , Membrana Epirretiniana/cirurgia , Humanos , Masculino , Tomografia de Coerência Óptica , Toxoplasmose Ocular/diagnóstico , Acuidade Visual , Vitrectomia
15.
J Cataract Refract Surg ; 47(12): e66-e69, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33929794

RESUMO

Implantation of an intraocular lens (IOL) after combined vitrectomy and cataract surgery is usually required to reduce postoperative refraction errors. However, because of the severe fibrosis of the anterior capsule and the adhesion between the anterior and posterior capsules, it is difficult to reopen the capsular bag to complete the secondary IOL implantation. In this study, a surgical approach is described for reopening the severe adhesion between capsules and removing the significant fibroproliferative membranous material by injecting ophthalmic viscosurgical device into the periphery of the capsular bag to separate the anterior and posterior capsules. The IOL was implanted into the capsular bag without any zonular rupture or posterior capsule tear. The position of the IOL was stable during postoperative follow-up up to 3 months. This procedure to open a severely fibrosis capsule was safe and effective.

16.
Aging (Albany NY) ; 13(6): 8835-8848, 2021 03 19.
Artigo em Inglês | MEDLINE | ID: mdl-33741751

RESUMO

While the impact of a 4-dimension lifestyle pattern (4DL) on older people's mortality (aged ≥65 years) has been reported in high-income countries, few studies investigated the association between lifestyle pattern and disease-accompanied mortality, or examined the difference among different age or gender groups in low- and middle-income countries. We followed up 16,954 Chinese older participants from 2008 to 2018 and adopted the Cox proportional hazard model to evaluate the protective effect of 4DL. After adjustment for confounders, individuals with 3-4 4DL scores had a 38% reduction in all-cause mortality risk, and up to 36%, 42% and 41% reduced risk of mortality accompanied by hypertension, respiratory disease and dementia, respectively in contrast with those scored 0. Compared with octogenarians, nonagenarians, and centenarians, adhering to 3-4 4DL could further reduce the mortality risks in the younger elderly (aged 65-79 years). This study shows that among the elderly population in China, participants who adhered to 4DL had a lower all-cause mortality risk than those who did not. Additionally, hypertension, respiratory disease, or dementia accompanied mortality risk was also reduced significantly. The findings indicated that the positive effects of 4DL on longevity should be acknowledged in China's older population, especially for the younger elderly.


Assuntos
Estilo de Vida , Longevidade , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos de Coortes , Feminino , Seguimentos , Humanos , Masculino , Fatores de Risco , Taxa de Sobrevida
17.
Angew Chem Int Ed Engl ; 60(20): 11326-11334, 2021 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-33626224

RESUMO

Two-dimensional (2D) nanomaterials are attracting much attention due to their excellent electronic and optical properties. Here, we report the first experimental preparation of two free-standing mercurated graphyne nanosheets via the interface-assisted bottom-up method, which integrates both the advantages of metal center and graphyne. The continuous large-area nanosheets derived from the chemical growth show the layered molecular structural arrangement, controllable thickness and enhanced π-conjugation, which result in their stable and outstanding broadband nonlinear saturable absorption (SA) properties (at both 532 and 1064 nm). The passively Q-switched (PQS) performances of these two nanosheets as the saturable absorbers are comparable to or higher than those of the state-of-the-art 2D nanomaterials (such as graphene, black phosphorus, MoS2 , γ-graphyne, etc.). Our results illustrate that the two metallated graphynes could act not only as a new class of 2D carbon-rich materials, but also as inexpensive and easily available optoelectronic materials for device fabrication.

18.
Neural Netw ; 138: 98-109, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33636485

RESUMO

Training a deep convolutional network from scratch requires a large amount of labeled data, which however may not be available for many practical tasks. To alleviate the data burden, a practical approach is to adapt a pre-trained model learned on the large source domain to the target domain, but the performance can be limited when the source and target domain data distributions have large differences. Some recent works attempt to alleviate this issue by imposing feature alignment over the intermediate feature maps between the source and target networks. However, for a source model, many of the channels/spatial-features for each layer can be irrelevant to the target task. Thus, directly applying feature alignment may not achieve promising performance. In this paper, we propose an Attentive Feature Alignment (AFA) method for effective domain knowledge transfer by identifying and attending on the relevant channels and spatial features between two domains. To this end, we devise two learnable attentive modules at both the channel and spatial levels. We then sequentially perform attentive spatial- and channel-level feature alignments between the source and target networks, in which the target model and attentive module are learned simultaneously. Moreover, we theoretically analyze the generalization performance of our method, which confirms its superiority to existing methods. Extensive experiments on both image classification and face recognition demonstrate the effectiveness of our method. The source code and the pre-trained models are available at https://github.com/xiezheng-cs/AFAhttps://github.com/xiezheng-cs/AFA.


Assuntos
Aprendizado de Máquina , Software/normas
19.
Int J Biochem Cell Biol ; 132: 105921, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33421632

RESUMO

Peripheral nerve injury (PNI) is encountered relatively commonly in the clinic and often results in long-term functional deficits. Research to develop methods to improve regeneration following nerve injury is ongoing. Numerous studies have shown that adipose-derived stem cells (ADSCs) promote the regeneration of peripheral nerve injury; however, the mechanism is unclear. Autophagy, a highly conserved intracellular process responsible for maintaining cellular homeostasis, and Schwann cells (SCs), play important roles in regeneration after PNI. In the present study, we explored the effect and mechanism of exosomes produced by adipose-derived stem cells (ADSC-Exos) on autophagy of SCs in PNI, as well as their effect on the regeneration of the nerve myelin sheath. The levels of autophagy and the expression of karyopherin subunit alpha 2 (Kpna2) in SCs increased markedly after the sciatic nerve was injured in SCs (SNI-SCs). The enhanced autophagy and the upregulated Kpna2 in SNI-SCs were inhibited after treatment with ADSC-Exos in vivo and in vitro. The effect of ADSC-Exos on inhibiting SC autophagy was blocked by overexpression of Kpna2 in SNI-SCs. Using quantitative real-time reverse transcription PCR, ADSC-Exos were demonstrated to contain a large amount of miRNA-26b, which was predicted to regulate Kpna2 on the TargetScan website. The effect of ADSC-Exos on inhibiting SCs autophagy was blocked after the silencing of miRNA-26b. Moreover, ADSC-Exos promoted the regeneration of the myelin sheath by inhibiting SC autophagy in rat SNI models. In conclusion, our results indicated that ADSC-Exos promote the regeneration of the myelin sheath by moderately reducing autophagy of injured SCs via miRNA-26b downregulation of Kpna2.


Assuntos
Tecido Adiposo/citologia , Exossomos/metabolismo , Bainha de Mielina/fisiologia , Regeneração Nervosa , Células de Schwann/citologia , Células-Tronco/citologia , Animais , Autofagia , Proliferação de Células , Traumatismos dos Nervos Periféricos/fisiopatologia , Traumatismos dos Nervos Periféricos/terapia , Ratos , Nervo Isquiático/lesões , Nervo Isquiático/fisiopatologia
20.
Orthop Surg ; 13(2): 451-457, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33480180

RESUMO

OBJECTIVE: To describe a new method which involves anatomical distal clavicle plate fixation and titanium alloy cable system-augmented coracoclavicular ligament reconstruction to manage Neer type IIb distal clavicle fracture. METHODS: Between January 2013 and June 2018, 28 patients with acute Neer type IIb lateral clavicle fracture were treated by a new method - precontoured locking compressive distal clavicular plate fixation of the fracture combined with titanium alloy cable system-augmented reconstruction of the coracoclavicular ligament. There were 11 females and 17 males treated in this way. There were 15 cases of the right side and 13 of the left. The mean age of the patients was 48.5 years (range, 18-78 years). The mean time from injury to surgery was 3.9 days (range, 1-7 days). After completing the preoperative examinations and evaluations, surgeries were performed for all these patients, anatomical distal clavicle plates were used for fractures, and titanium alloy cables were implanted for the augmented reconstruction of coracoclavicular ligaments. Postoperative protocols, including arm sling management and rehabilitative activities, were unified and recommended to all the patients. These patients were followed up for at least 1 year. The mean duration of postoperative follow-up was 23.3 months (range, 12-52 months). At the last follow-up, the coracoclavicular distances were recorded and shoulder functional outcomes were assessed by the Constant scores and the Fudan University Shoulder Scores (FUSSs) questionnaires. RESULTS: Radiographic bony unions were achieved in all patients within 20 weeks. Functional and radiographic outcomes were retrospectively evaluated. The mean coracoclavicular distance was 9.61 ± 0.61 mm on the injured side vs 9.62 ± 0.57 mm on the contralateral uninjured side. The mean Constant score and mean FUSS were 90.1 ± 6.6 (range, 68-98) and 86.1 ± 7.2 (range, 64-95) respectively, which indicating good restoration of function and high level of satisfaction for both the patients and their physical therapists. There were a few major complications, including one delayed healing of the skin, one severe shoulder stiffness, three incidences of moderate shoulder stiffness, and five incidences of symptomatic hardware. There is no deep infections, neurovascular injuried, delayed union or nonunion, peri-implant fracture, loss of reduction, implant malposition or failure, or other severe complications. CONCLUSION: This combined method for the treatment of Neer type IIb distal clavicle fracture could yield high bony union rate, good functional outcome, and low complication rate. Further prospective randomized controlled studies are needed to confirm the benefits of this method of treatment.


Assuntos
Placas Ósseas , Clavícula/cirurgia , Fixação Interna de Fraturas/instrumentação , Fraturas Ósseas/cirurgia , Ligamentos Articulares/cirurgia , Âncoras de Sutura , Adolescente , Adulto , Idoso , Clavícula/lesões , Feminino , Fixação Interna de Fraturas/métodos , Humanos , Ligamentos Articulares/lesões , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Inquéritos e Questionários , Titânio , Adulto Jovem
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