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1.
Food Chem ; 398: 133848, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35964572

RESUMO

Aflatoxin M1 (AFM1) is an important risk factor threatening the safety of milk and dairy products due to its carcinogenic and teratogenic effects on humans. To prevent AFM1 from causing damage to human health, developing reliable methods to monitor its levels in milk and dairy products is of great importance. Biosensors built with recognition and detection systems have attracted extensive attention for their simplicity, portability, sensitivity, and selectivity. The commonly developed biosensors for detecting AFM1 are antibody-based sensors (immunosensors) and aptamer-based sensors (aptasensors). This review focused on the advances of immunosensors, aptasensors, and other emerging receptors-based sensors for the detection of AFM1 in milk and dairy products in the past five years. These biosensors were reviewed with representative examples according to their signal transduction systems, mainly including colorimetry, fluorescence, electrochemistry, and others. The unique advantages and drawbacks of immunosensor and aptasensor, and the future opportunities and challenges were also discussed.


Assuntos
Aflatoxina M1 , Técnicas Biossensoriais , Aflatoxina M1/análise , Animais , Técnicas Biossensoriais/métodos , Laticínios/análise , Eletroquímica , Contaminação de Alimentos/análise , Humanos , Imunoensaio , Leite/química
2.
Diagnostics (Basel) ; 12(9)2022 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-36140618

RESUMO

Artificial intelligence (AI) adopting deep learning technology has been widely used in the med-ical imaging domain in recent years. It realized the automatic judgment of benign and malig-nant solitary pulmonary nodules (SPNs) and even replaced the work of doctors to some extent. However, misdiagnoses can occur in certain cases. Only by determining the causes can AI play a larger role. A total of 21 Coronavirus disease 2019 (COVID-19) patients were diagnosed with SPN by CT imaging. Their Clinical data, including general condition, imaging features, AI re-ports, and outcomes were included in this retrospective study. Although they were confirmed COVID-19 by testing reverse transcription-polymerase chain reaction (RT-PCR) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their CT imaging data were misjudged by AI to be high-risk nodules for lung cancer. Imaging characteristics included burr sign (76.2%), lobulated sign (61.9%), pleural indentation (42.9%), smooth edges (23.8%), and cavity (14.3%). The accuracy of AI was different from that of radiologists in judging the nature of be-nign SPNs (p < 0.001, κ = 0.036 < 0.4, means the two diagnosis methods poor fit). COVID-19 patients with SPN might have been misdiagnosed using the AI system, suggesting that the AI system needs to be further optimized, especially in the event of a new disease outbreak.

3.
Ecotoxicol Environ Saf ; 244: 114039, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-36049333

RESUMO

BACKGROUND: Evidence suggests that exposure to PM2.5 increased hospitalization and mortality rates of respiratory diseases. However, the potential biomarkers and targets associated with PM2.5-induced lung dysfunction are not fully discovered. METHODS: Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and HALLMARK enrichment analysis of the RNA-seq data (Beas-2B cells treated with PM2.5) were applied. Gene set enrichment analysis (GSEA) was performed to identify the biological processes correlated with autophagy. Three gene expression profile datasets (GSE158954, GSE155616 and GSE182199) were downloaded from the Gene Expression Omnibus (GEO) database to identify the potential targets. PM2.5-exposed mice were constructed. Real-time qPCR, siRNA transfection, western blot, immunofluorescence, and pathological staining were applied for validation both in vitro and in vivo studies. RESULTS: GO, KEGG and HALLMARK enrichment based on RNA-seq data showed that the differentially expressed genes (DEGs) were associated with autophagy like lysosome and macroautophagy. GSEA analysis revealed that PM2.5 was positively correlated with autophagy-related biological processes compared with control group. Venn diagrams identified IL24 was upregulated in our data as well as in these three datasets (GSE158954, GSE155616 and GSE182199) after PM2.5 exposure. Consistent with the analysis, activation of autophagy by PM2.5 was validated in vivo and in vitro. In PM2.5-exposed mice, lung pathological changes were observed, including airway inflammation and mucus secretion. The mRNA and protein levels of the key gene, IL24, were significantly increased. Moreover, Bafilomycin A1, the inhibitor of autophagy, inhibited the autophagy and ameliorated lung injury induced by PM2.5. Furthermore, downregulation of IL24 decreased autophagy activity. Meanwhile, IL24 was regulated by mTOR signaling. CONCLUSIONS: In summary, we discovered a potential relationship between IL24 and autophagy during PM2.5 exposure. IL24 might be a novel potential biomarker or therapeutic target in PM2.5 caused lung dysfunction through regulation of autophagy.

4.
Artigo em Inglês | MEDLINE | ID: mdl-36099486

RESUMO

The aim of the current review was to assess whether parent-performed infant massage (PPIM) could effectively improve the mental state of parents during the postpartum period. Several international electronic databases were thoroughly searched for relevant articles. Included studies observed the influence of PPIM on the mental state of parents of healthy full-term infants within 18 months postpartum or medically stable preterm infants during hospitalization after birth. Nine studies were included, which observed one or more aspects of parental mental state, including depression, anxiety, parental stress, or general mood state. Characteristics of participants, massage protocols, and outcome measures were heterogenous; hence, results regarding the influence of PPIM on parental mental state were inconsistent. Upon further investigation, 10-minute, home-based PPIM for at least 4 weeks is advisable for maternal depression within 5 months postpartum. Moreover, PPIM in a neonatal intensive care unit is advisable for improving the general mood of mothers of preterm infants. Additional methodologically rigorous studies are needed to provide stronger evidence. [Journal of Psychosocial Nursing and Mental Health Services, xx(x), xx-xx.].

5.
Orthop Surg ; 2022 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-36120825

RESUMO

OBJECTIVE: How to restrict sliding of cephalomedullary nail and rigid reconstruct medial support for unstable intertrochanteric fractures remains a challenge. This study aims to explore the feasibility of a novel cephalomedullary nail for restriction sliding and reconstruction of medial femoral support to prevent failure in unstable trochanteric fractures through finite element analysis. METHODS: The DICOM files of a unilateral femur spiral computed tomography (CT) scans from a elderly female were converted into STL files, and the most common clinical trochanteric fracture model with the absence of medial support, AO/OTA 31-A2.3 was simulated by removing the posterior medial femur. The model of a novel medial sustain nail (MSN-II) and a widely used nail (proximal femoral nail anti-rotation PFNA-II) were modeled according to the manufacturer-provided engineering drawing. Different loads were applied to the femoral head to simulate the postoperative weight bearing gait. The sliding distance of helical blade in femoral neck, maximum stress of femur and nail, displacement of proximal fragment were analyzed to revealing the mechanical stability of unstable trochanteric fracture stabilized by different implant. RESULTS: The sliding distance of helical blade in the femoral neck, the maximum stress on the femur and nail, the displacement of proximal fragment in MSN-II under 2100N axial load were 0.65 mm, 689 MPa, 1271 MPa, 16.84 mm respectively, while that were 1.43 mm, 720.8 MPa, 1444 MPa, 18.18 mm, respectively in PFNA-II. The difference between the two groups was statistically significant (P < 0.05) and the stress was mainly distributed in medial distal side of nail but helical blade and the proximal aperture for the nail in MSN-II. Compared to PFNA-II, MSN-II demonstrates biomechanical merit against femur medialization, cut-out and coax varus. CONCLUSION: The sliding distance of helical blade in femoral neck, the maximum stress on the femur and nail, and the displacement of proximal fragment of MSN-II were less than those of PFNA-II in the treatment of unstable intertrochanteric fractures. Therefore MSN-II has better stability than PFNA-II and it may have the potential to avoid femur medialization and cut out. It might be an option in unstable trochanteric fracture because of its superiority in restricted sliding and medial support reconstruction.

6.
Talanta ; 252: 123864, 2022 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-36057164

RESUMO

In this work, endogenous metabolites in mouse brain tissue were imaged by negative desorption electrospray ionization (DESI), ammonia assisted DESI (aa-DESI), DESI/post-photoionization (DESI/PI), and ammonia assisted DESI/PI (aa-DESI/PI) mass spectrometry imaging (MSI) strategies. The combined effect of ammonia additive and post-photoionization was found to play an important role in the enhancement of sensitivity and coverage for endogenous analytes under ambient conditions. Compared with DESI, aa-DESI/PI can provide increased signal intensities for metabolites up to 37.1-fold, as well as the imaging of nine more small metabolites (m/z < 350) (26 for aa-DESI/PI and 17 for DESI) in mouse brain tissue. The results of Pearson correlation analysis and KEGG pathway analysis showed that the enhanced imaging strategy of aa-DESI/PI can facilitate the study of endogenous metabolic pathways and molecular networks. Moreover, the imaging results of mouse tumor tissue demonstrated the promising application of aa-DESI/PI in tumor research.

7.
Zhongguo Gu Shang ; 35(9): 848-52, 2022 Sep 25.
Artigo em Chinês | MEDLINE | ID: mdl-36124455

RESUMO

OBJECTIVE: To explore effects of acupotomy on pain, function, gait and serum inflammatory factors in patients with knee osteoarthritis(KOA). METHODS: From December 2017 to June 2019, 110 patients with KOA were collected and divided into acupotomy group(56 cases) and western medicine group(54 cases) by using random number table method. In acupotomy group, there were 16 males and 40 females, aged from 46 to 74 years old with an average of (62.98±6.68) years old, the course of disease ranged from 1 to 240 months with an average of 24.5(15.25, 33.00) months;were treated with acupotomy on the pain points around knee joint once a week for 3 weeks. In western medicine group, there were 18 males and 36 females, aged from 47 to 73 years old with an average of (64.19±5.98 ) years old;the course of disease ranged from 1 to 220 months with an average of 25.00(13.75, 33.00) months;were took celecoxib capsule orally, 200 mg once a day for 3 weeks. Oxford Knee Score(OKS) was performed before treatment, 3 weeks and 3 months after treatment. Gait kinematics analysis and serum levels of tumor necrosis factor-α(TNF-α) and interleukin-1ß (IL-1ß) were measured before and after treatment for 3 weeks. RESULTS: All patients were followed up from 6 to 24 months with an average of(15.03±4.55) months. OKS between two groups decreased significantly at 3 weeks and 3 months after treatment(P<0.001). Functional scores and overall scores in acupotomology group were significantly decreased at 3 months compared with 3 weeks after treatment(P<0.001). OKS of acupotomy group were significantly lower than those of western medicine group at 3 weeks and 3 months after treatment(P<0.05). Gait speed, frequency and length between two groups were significantly improved at 3 weeks after treatment(P<0.05). At 3 weeks after treatment, gait freguency of acupotomy group was significantly improved compared with western medicine group(P<0.05). TNF-α and IL-1ß were significantly lower in both groups at 3 weeks after treatment than before treatment(P<0.05). At 3 weeks after treatment, level of IL-1 ß was lower in western medicine group than in acupotomy group(P<0.05), and difference in TNF-α level was not statistically significant(P>0.05). CONCLUSION: Acupotomology of pain points could significantly improve pain, function, gait, and decreased serum inflammatory factors at early to mid stage of KOA patients, in particular, it is superior to non-steroidal anti-inflammatory drugs in terms of knee function recovery and cadence improvement.


Assuntos
Terapia por Acupuntura , Osteoartrite do Joelho , Idoso , Anti-Inflamatórios não Esteroides/uso terapêutico , Celecoxib/uso terapêutico , Feminino , Marcha , Humanos , Interleucina-1beta , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/tratamento farmacológico , Dor/tratamento farmacológico , Fator de Necrose Tumoral alfa
8.
Front Pharmacol ; 13: 936899, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36110553

RESUMO

Background: The application of flipped classroom (FC) pedagogy has recently become increasingly popular in Chinese pharmacy education. However, its effectiveness in improving student learning has not yet been assessed. This study aimed to evaluate the effects of teaching with such pedagogical approach by examining studies that compare the FC approach with the traditional lecture-based learning (LBL) module through a systematic review and meta-analysis. Methods: Seven databases, including the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Chinese Wanfang database, and China Biomedical Literature Database, were searched from the inception to 30 June 2021, to identify eligible articles of randomized controlled studies. The primary outcomes included the theoretical and experimental test scores, and the secondary outcomes were the results from questionnaires about the number of students who preferred the FC or endorsed its improving effects on their learning enthusiasm, self-learning ability, thinking skills, communication skills, and learning efficiency. The quantitative synthesis was conducted with Revman V.5.3 software following the Cochrane Reviewer's Handbook guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: Eleven eligible studies published from 2017 to 2020 enrolling 1,200 students were included in this meta-analysis. The quantitative synthesis demonstrated that the FC module presented an overall more significant effectiveness over traditional LBL approach for Chinese pharmacy education in improving student academic performance as measured by theoretical test scores (SMD = 1.08, 95% CI: 0.60-1.56, p < 0.00001) and experimental test scores (MD = 6.62, 95% CI: 4.42-8.82, p < 0.00001). Further sub-group analysis revealed that the preferable effectiveness of FC was also evident in both theory-oriented (SMD = 0.77, 95% CI: 0.10-1.45, p < 0.00001) and experiments-oriented courses (MD = 6.52, 95% CI: 3.48-9.56, p < 0.00001) for both undergraduate (SMD = 0.84, 95% CI: 0.31-1.37, p < 0.00001) and 3-year junior-college students (MD = 8.17, 95% CI: 6.44-9.89, p < 0.00001). Additionally, analysis on the questionnaire outcomes revealed that more respondents preferred for FC and endorsed its improvement effects on developing students' learning enthusiasm, self-learning ability, thinking skills, communication skills, and learning efficiency. Conclusion: Current evidence suggests that FC pedagogical approach can effectively improve student learning outcomes and is applicable to Chinese pharmacy education.

9.
Front Neurosci ; 16: 966087, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35968369

RESUMO

Purpose: The major depressive disorder (MDD) can be a threat to the health of people all over the world. Although governments have developed and implemented evidence-based interventions and prevention programs to prevent MDD and maintain mental health in adolescents, the number of adolescents with this condition has been on the rise for the past 10 years. Methods: A total of 60 adolescents were recruited, including 32 drug-naive adolescents with first-episode MDD and 28 healthy controls (HCs). Alterations in the intrinsic cerebral activity of the adolescents with MDD were explored using arterial spin labeling (ASL) while differences in the regional cerebral blood flow (rCBF) of the two groups were assessed based on voxel-based whole-brain analysis. Finally, correlations between the regional functional abnormalities and clinical variables were investigated for adolescents with MDD. Results: Compared with HCs, MDD patients had a lower rCBF in the left triangular part of the inferior frontal gyrus (IFGtriang) but a higher one in the right Precental gyrus (PreCG). Negative correlations were also noted between the CBF in the left IFGtriang and the Hamilton depression scale (HAMD) scores of MDD patients. Conclusion: Elucidating the neurobiological features of adolescent patients with MDD is important to adequately develop methods that can assist in early diagnosis, precaution and intervention.

10.
Contrast Media Mol Imaging ; 2022: 4863682, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35992545

RESUMO

In order to explore more ideal intravenous anesthesia drug in clinical practice, the analgesic effect of remazolam combined with etomidate in painless gastroenteroscopy and its effect on stress response is investigated. A total of 100 patients are selected for the gastric disease screening, and they are randomly divided into the single-drug group and composite group, with 50 cases in each group. Etomidate, mazzolone, and etomidate are used to anesthetize the patients, and then, the effects of different solutions on analgesia, sedation, and stress response are compared and analyzed, and the adverse reactions are improved. The etomidate and red horse azole shimron composite etomidate anesthesia were applied, and the comparative analysis of different solutions of analgesic, sedative effect, and response to stress is conducted. Then, the improvement of adverse reactions is analyzed. The experimental results demonstrate that remazolam combined with etomidate anesthesia can reduce the level of pain mediators and enhance the analgesia and sedation effect. Meanwhile, combined anesthesia can reduce the stress response and adverse reactions of patients and shorten the examination period effectively.


Assuntos
Anestesia , Etomidato , Propofol , Anestésicos Intravenosos/efeitos adversos , Animais , Etomidato/efeitos adversos , Cavalos , Propofol/efeitos adversos
11.
Health Sci Rep ; 5(5): e778, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36000081

RESUMO

Background and Aims: The novel coronavirus disease 2019 (COVID-19) causes severe respiratory illnesses, following exposure to air-borne droplets or direct contact, posing a great threat to human life. This study aimed to investigate perceived stress and its correlation with the health behaviors of Chinese residents during the COVID-19 epidemic. Methods: An Internet survey was conducted among 2449 residents in 20 provinces of China on residents' perceived stress, perception of COVID-19, and health behaviors. SAS 9.4 was used to analyze the relationship between health behaviors and perceived stress, and logistic regression was used to explore the factors influencing health risk stress. Results: The participants' perceived stress score was 22.25 ± 7.2 (total 56), and the incidence of health risk stress was 39.89% (977/2449). Females, students, and medical staff were at high risk. Health risk stress refers to a level of stress that is hazardous to health (score over 25). Perceived stress increased, while the frequency of health behaviors decreased. Age, perception of susceptibility to COVID-19, life-threatening level of COVID-19, perception of the importance of home isolation, and perception of the difference between a common cold and COVID-19 were positively related to the occurrence of health risk stress. Conclusions: A negative correlation was found between health behaviors and perceived stress. Therefore, it is of great significance to provide psychological interventions for those who are experiencing health risk stress and to promote their health behaviors.

12.
Anal Chim Acta ; 1221: 340143, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35934375

RESUMO

Damaging the structure of the G-quadruplex (G4) to prevent the formation of the G4/hemin complex is presently the only available method to inhibit the activity of the peroxidase-mimic DNAzyme. In this study, a unique intramolecular inhibitory effect of the adjacent base-pair (InE(N:N)), by installing a rationally adjacent base-pair of the G4 core sequence, is proposed for the inhibition of the DNAzyme activity, which eliminates the need to damage the entire G4 structure. Various base pairs show different abilities to inhibit DNAzyme activity. The adjacent adenine: thymine pair possesses the best inhibitory efficiency (17 times). Through detailed investigations of the InE(N:N), it was revealed that the adjacent adenine: thymine pair downregulated the formation of compound I in the catalytic process, thus inhibiting the G4 DNAzyme activity. The mechanism of inhibition indicated that the carbonyl group on the hexatomic ring of the complementary base played an important role. To further reflect the advantages of the proposed strategy, two InE(N:N)-based biosensors were developed for DNA analysis and Uracil-DNA glycosylase (UDG) detection. Compared with existing DNAzyme-based methods, the application of InE(N: N) facilitates the real-time assay and simplifies the design difficulty. Therefore, InE(N:N) provides new insights into the regulation of the DNAzyme activity and offers an efficient approach for the future application of DNAzyme.


Assuntos
Técnicas Biossensoriais , DNA Catalítico , Quadruplex G , Adenina , Técnicas Biossensoriais/métodos , Corantes , DNA Catalítico/química , Hemina/química , Peroxidase/metabolismo , Peroxidases/química , Timina
13.
J Exp Clin Cancer Res ; 41(1): 238, 2022 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-35934718

RESUMO

BACKGROUND: Epithelial ovarian cancer (EOC) is the leading cause of deaths among patients with gynecologic malignancies. In recent years, cancer stem cells (CSCs) have attracted great attention, which have been regarded as new biomarkers and targets in cancer diagnoses as well as therapies. However, therapeutic failure caused by chemotherapy resistance in late-stage EOC occurs frequently. The 5-year survival rate of patients with EOC remains at about 30%. METHODS: In this study, the expression of acylglycerol kinase (AGK) was analyzed among patients with EOC. The effect of AGK on EOC cell proliferation and tumorigenicity was studied using Western blotting, flow cytometry, EdU assay and in vivo xenotransplantation assays. Furthermore, AGK induced CSC-like properties and was resistant to cisplatin chemotherapy in the EOC cells, which were investigated through sphere formation assays and the in vivo model of chemoresistance. Finally, the relationship between AGK and RPL39 (Ribosomal protein L39) in mitochondria as well as their effect on the mitochondrial function was analyzed through methods including transmission electron microscopy, microarray, biotin identification and immunoprecipitation. RESULTS: AGK showed a markedly upregulated expression in EOC, which was significantly associated with the poor survival of patients with EOC, the expression of AGK-promoted EOC cell proliferation and tumorigenicity. AGK also induced CSC-like properties in the EOC cells and was resistant to cisplatin chemotherapy. Furthermore, the results indicated that AGK not only maintained mitochondrial cristae morphogenesis, but also increased the production of reactive oxygen species and Δψm of EOC cells in a kinase-independent manner. Finally, our results revealed that AGK played its biological function by directly interacting with RPL39. CONCLUSIONS: We demonstrated that AGK was a novel CSC biomarker for EOC, which the stemness of EOC was promoted and chemotherapy resistance was developed through physical as well as functional interaction with RPL39.


Assuntos
Carcinoma Epitelial do Ovário/metabolismo , Neoplasias Ovarianas , Fosfotransferases (Aceptor do Grupo Álcool) , Proteínas Ribossômicas/metabolismo , Carcinoma Epitelial do Ovário/patologia , Proliferação de Células , Cisplatino/farmacologia , Cisplatino/uso terapêutico , Feminino , Humanos , Mitocôndrias/metabolismo , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/patologia , Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo
14.
Cell ; 185(17): 3124-3137.e15, 2022 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-35944541

RESUMO

During development, melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) become light sensitive much earlier than rods and cones. IpRGCs project to many subcortical areas, whereas physiological functions of these projections are yet to be fully elucidated. Here, we found that ipRGC-mediated light sensation promotes synaptogenesis of pyramidal neurons in various cortices and the hippocampus. This phenomenon depends on activation of ipRGCs and is mediated by the release of oxytocin from the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) into cerebral-spinal fluid. We further characterized a direct connection between ipRGCs and oxytocin neurons in the SON and mutual projections between oxytocin neurons in the SON and PVN. Moreover, we showed that the lack of ipRGC-mediated, light-promoted early cortical synaptogenesis compromised learning ability in adult mice. Our results highlight the importance of light sensation early in life on the development of learning ability and therefore call attention to suitable light environment for infant care.


Assuntos
Ocitocina , Células Ganglionares da Retina , Animais , Encéfalo/metabolismo , Humanos , Camundongos , Células Ganglionares da Retina/fisiologia , Opsinas de Bastonetes/metabolismo
15.
Contrast Media Mol Imaging ; 2022: 3163230, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35965623

RESUMO

Objective: To evaluate the effect of dietary care on chemotherapy-induced nausea and vomiting in oncology patients. Methods: A retrospective analysis of digestive symptoms was conducted in cancer patients admitted to our hospital, who received chemotherapy, and corresponding effective dietary care countermeasures were adopted. Results: After the nursing intervention, the incidence of digestive symptoms was significantly reduced, the quality of life was significantly improved (59.92 ± 6.57) vs. (37.95 ± 7.50), and the nursing satisfaction was significantly higher (91.67% vs. 69.44%), with statistically significant differences (P < 0.05). Meta-analysis showed that short-term (0 to 3 months) dietary care could alleviate nausea and vomiting symptoms in chemotherapy patients (P < 0.001) and improve the survival quality of oncology patients (P < 0.01). The effect of long-term (3-6 months) dietary care on the control of nausea and vomiting symptoms in chemotherapy patients was certain (P < 0.05), but the effect on the improvement of their quality of life (P > 0.05) was unclear. Conclusion: Dietary care can alleviate the symptoms of nausea and vomiting in tumor chemotherapy patients and improve the quality of life of short-term chemotherapy tumor patients, so it can be recommended to strengthen the dietary management for tumor patients receiving chemotherapy. Patients receiving chemotherapy should be given corresponding dietary nutritional care according to their clinical symptoms in order to alleviate their adverse reactions, enhance their own immunity, and improve the prognosis of cancer patients.


Assuntos
Antineoplásicos , Neoplasias , Antineoplásicos/efeitos adversos , Humanos , Náusea/induzido quimicamente , Náusea/tratamento farmacológico , Neoplasias/tratamento farmacológico , Qualidade de Vida , Estudos Retrospectivos , Vômito/induzido quimicamente , Vômito/tratamento farmacológico
16.
Hemodial Int ; 2022 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-35973968

RESUMO

A femoral artery pseudoaneurysm (FAP) is a serious complication of arterial injury. It can cause compression of the surrounding nerves and tissues, rupture and bleeding of the aneurysm, and formation and dislodgement of thrombi, and can lead to distal limb embolism, tissue necrosis, and infection. Computed tomography angiography and ultrasonography are the preferred techniques for diagnosis of FAP. This report describes the successful treatment of an FAP using an ultrasound-guided percutaneous intracavitary injection of a lyophilized human fibrin sealant. This treatment was safe, associated with minimal pain and complications, and clinically effective.

17.
Dalton Trans ; 51(35): 13301-13310, 2022 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-35983759

RESUMO

A tunable multimode white emission Ca2(Mg0.5Al0.5)(Si1.5Al0.5O7):Eu2+/Eu3+ phosphor was prepared by doping Eu2O3 in molten high-aluminum blast furnace slag. The structural probe Eu2+ was studied during phase transformation between the glassy state and Ca2(Mg0.5Al0.5)(Si1.5Al0.5O7) crystals based on site-selective Eu2+ occupancy. When the doped Eu2+ ions occupied two different Ca2+ sites in the matrix, blue light (421 nm) and green light (516 nm) emissions were observed corresponding to two types of Eu2+Ca2+, namely Eu2+Ca2+ (Mg2+ → Al3+) and Eu2+Ca2+ (Si4+ → Al3+). The effects of Eu concentration (0.1-2.0 mol%), heat treatment temperature (800-1000 °C), and thermal quenching temperature (30-150 °C) on the structural evolution of the emission unit were studied by differential scanning calorimetry (DSC), photoluminescence spectroscopy (PL) and X-ray diffraction (XRD) analyses. The Eu2+Ca2+ (Mg2+ → Al3+) structure formed by site-selective Eu2+ occupancy possessed better structural stability in the Ca2(Mg0.5Al0.5)(Si1.5Al0.5O7) crystal matrix, in favour of light-emitting diode (LED) illumination and plasma display panels (PDPs).

18.
J Am Chem Soc ; 144(31): 14101-14111, 2022 08 10.
Artigo em Inglês | MEDLINE | ID: mdl-35913786

RESUMO

The NanoLuc luciferase (NLuc) and its furimazine (FRZ) substrate have revolutionized bioluminescence (BL) assays and imaging. However, the use of the NLuc-FRZ luciferase-luciferin pair for mammalian tissue imaging is hindered by the low tissue penetration of the emitting blue photons. Here, we present the development of an NLuc mutant, QLuc, which catalyzes the oxidation of a synthetic QTZ luciferin for bright and red-shifted emission peaking at ∼585 nm. Compared to other small single-domain NLuc mutants, this amber-light-emitting luciferase exhibited improved performance for imaging deep-tissue targets in live mice. Leveraging this novel bioluminescent reporter, we further pursued in vivo immunobioluminescence imaging (immunoBLI), which used a fusion protein of a single-chain variable antibody fragment (scFv) and QLuc for molecular imaging of tumor-associated antigens in a xenograft mouse model. As one of the most red-shifted NLuc variants, we expect QLuc to find broad applications in noninvasive mammalian imaging. Moreover, the immunoBLI method complements immunofluorescence imaging and immuno-positron emission tomography (immunoPET), serving as a convenient and nonradioactive molecular imaging tool for animal models in basic and preclinical research.


Assuntos
Âmbar , Pirazinas , Animais , Furanos , Humanos , Imidazóis , Luciferases/genética , Luciferases/metabolismo , Medições Luminescentes/métodos , Mamíferos/metabolismo , Camundongos
19.
Environ Sci Technol ; 56(17): 12077-12085, 2022 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-35939835

RESUMO

Traditionally, environmental authorities make regulatory policies for controlling volatile organic compound (VOC) pollution based on the mitigation of dominant VOC sources. However, the emission from each VOC source has a unique combination of VOC species of different toxicities. Without quantitatively assessing the health risk associated with each source, the effectiveness of the mitigation policy could be undermined. To address this shortcoming, we developed a new health risk-oriented source apportionment method that can provide quantitative health risk assessment and source-specific mitigation strategies for hazardous VOCs. We estimated that the integrated inhalation cancer risk (ICR) of hazardous VOCs was 7.7 × 10-5 in Western Canada, indicating a 100% likelihood of exceeding Health Canada's acceptable risk level (1.0 × 10-5). Anthropogenic sources were responsible for 56.3-73.8% of cancer risks across eight Canadian cities except for the regional background island, where natural sources contributed over 77% to the integrated ICR. Thus, substantial environmental and health cobenefits could be achieved via reducing the ambient levels of benzene and 1,3-butadiene by 39.3-75.7 and 14-69.3%, respectively, and mitigating emissions from fuel combustion (by 31.3-54.1%), traffic source (3.0-36.8%), and other anthropogenic sources (5.3-20.1%) in Western Canada. Our study has significant implications for prioritizing air pollution mitigation policies, especially for quantitative reduction of hazardous air pollutants.


Assuntos
Poluentes Atmosféricos , Ozônio , Compostos Orgânicos Voláteis , Poluentes Atmosféricos/análise , Canadá , China , Cidades , Monitoramento Ambiental , Ozônio/análise , Emissões de Veículos/análise
20.
J Biophotonics ; : e202200101, 2022 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-35852139

RESUMO

We reported the development of a bimodal large field of view (~95 cm2 ) polarization-sensitive (PS) imaging and point-wise diffuse reflectance (DR) spectroscopy platform synergising the advantages of the two modalities. PS-DR spectroscopy allows simultaneous label-free biochemical and structural analysis of the investigated tissue. For real applications, the PS imaging first grossly stratified tissue into different categories, followed by high information dimension PS-DR spectroscopy ascertaining ambiguous tissue regions identified by the PS imaging. Tested on a tissue phantom consisting of porcine esophagus muscularis propria and submucosa, it has demonstrated the system developed could complete tissue interrogation within 0.6 minutes and with separation accuracy of 95.87%. Further test on tissue phantom consisting of natural and crushed bovine tendon mimicking normal and cancerous breast tissues validated the potential of system developed to effectively and rapidly investigate large tissue area, facilitating augmented tissue boundary demarcation.

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