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1.
Sci Total Environ ; 716: 137010, 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-32044484

RESUMO

The accelerating urbanization has led to serious air pollution dominated by PM2.5, posing a critical challenge for the environmental sustainability of the Belt and Road Initiative (BRI). However, a focus on the distribution and drivers of PM2.5 concentrations in BRI is lacking. To fill in the gap, this study explores the spatio-temporal distribution of PM2.5 concentrations in 74 nations partnering the BRI and identifies the socioeconomic and natural drivers behind the variation through the joint use of spatial autocorrelation and regression analyses. We find that the PM2.5 concentrations of BRI show significant spatial autocorrelation and spatial heterogeneity on the national scale. The most heavily polluted regions are observed mainly in China, Southeast Asia, South Asia, West Asia and North Africa, particularly in the Arabian Gulf region. Energy intensity and per capita electricity consumption act as the major drivers of the PM2.5 concentrations, whereas the expanding forest area contributes to the decrease in PM2.5 concentrations notably. Our findings highlight the need for speeding up new-type urbanization as part of the green BRI practice, calling for international cooperation and coordinated action aimed at enhancing synergies of air-quality and climate policies that at present are mostly launched and implemented in isolation. From a broader point of view, in struggling towards BRI's cleaner air, more attention should be paid to creating policy synergies between the green BRI, the Paris Agreement, and the United Nations 2030 Agenda for Sustainable Development.

2.
Cancer Cell Int ; 19: 324, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31827398

RESUMO

Background: Spindle and kinetochore associated protein 1 (SKA1) is a protein involved in chromosome congression and mitosis. It has been found to be upregulated and oncogenic in several human cancers. Herein, we investigated the precise role of SKA1 in the progression and malignant phenotype of human glioma. Methods: Bioinformatic analysis was carried out based on the RNA-seq data and corresponding clinical data from GEO, TCGA and CGGA databases. Western blot was performed to analyze the expression of SKA1 in clinical samples and signaling pathway proteins in glioma cells, respectively. CCK8 assay, colony forming assay and EdU assay were performed to assess the cell viability. Cell migration and invasion assays were also performed. Moreover, xenograft model was established and the expression of SKA1 was assessed in the xenograft by immunohistochemistry. Results: SKA1 expression is positively correlated with glioma grade and could be a promising biomarker for GBM. Moreover, overexpression of SKA1 may lead to poor prognosis in glioma. Downregulation of SKA1 attenuated cell viability, migration, and invasion in U251, U87, LN229 and T98 cells. Furthermore, GSEA analysis demonstrated that SKA1 was involved in the cell cycle, EMT pathway as well as Wnt/ß-catenin signaling pathway, which were then confirmed with Western blot analysis. Conclusion: SKA1 promotes malignant phenotype and progression of glioma via multiple pathways, including cell cycle, EMT, Wnt/ß-catenin signaling pathway. Therefore, SKA1 could be a promising therapeutic target for the treatment of human gliomas.

3.
Psych J ; 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31795011

RESUMO

Doctor-patient communication interacts with patients' satisfaction to influence patients' risk perception. Current theories to explain this relationship have assumed particular psychological processes to explain observations of risk-sensitive behavior in an economic setting, but as of yet, they have not addressed whether it is adaptive for a decision-maker in a health-care situation. In addition, little is known about the role of interpersonal trust between doctor and patient. We surveyed 602 patients to examine the way in which trust, communication, and patients' satisfaction are related to patients' risk perception about uncertainties in medical treatment. The results showed that patients held a relatively low level of risk perception, which means that they had insufficient preparation for the possibility of uncertainties about the treatment. The association between doctor-patient communication and patients' perceived risk was mediated by doctor-patient trust. These results suggest that there is a relationship among good doctor-patient communication, patients' trust in medical staff, and perceived risk during medical treatment. Finally, theoretical and practical implications are discussed.

4.
J Adv Nurs ; 75(12): 3434-3447, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31566769

RESUMO

AIMS: To integrate the overall effect of e-health based self-management on cancer-related fatigue (CRF), self-efficacy, and quality of life (QOL) among adult cancer patients. DESIGN: A systematic review and meta-analysis of randomized controlled trials. DATA SOURCES: We researched PubMed, Cumulative Index Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Web of Science and Embase up to 14 July 2019. REVIEW METHODS: We conducted the review with the Cochrane Handbook (version 5.1.0) and measured the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation criteria. RESULTS: Literature searching identified 15 trials with a total of 2,337 participants. Integrated results analysis of e-health based self-management demonstrated a statistically significant but small effect on CRF and self-efficacy, but no statistically significant improvement on the QOL. Meanwhile, subgroup analysis indicated that e-health based self-management had a larger effect on fatigue compared with usual care/waiting list control. CONCLUSION: E-health based self-management is effective for CRF and self-efficacy, but not the QOL. More high-quality randomized control trials are warranted to confirm these conclusions. IMPACT: Results showed e-health could improve fatigue and self-efficacy but not the QOL. Health providers could take into the various factors of e-health interventions when providing telehealth service. Other researchers might be inspired by the current review before they begin a study about e-health.

5.
Biosci Rep ; 39(2)2019 02 28.
Artigo em Inglês | MEDLINE | ID: mdl-30760630

RESUMO

Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell clusters and their role in adipose tissue regeneration remain unknown. Aim: In the present study, we evaluated EVE in the construction of expanded prefabricated adipose tissue (EPAT) in a rat model. Methods: Rats were randomized into an EVE suction group and a control group, with 24 rats in each group. The structure and origin of the special cell clusters were determined by hematoxylin and eosin staining, and immunohistochemistry; their role in adipose tissue regeneration was investigated by immunohistochemistry and Western blot analyses. Results: Special cell clusters began to increase at week 1 with a peak at week 4, and then receded from weeks 8 to 12. Clusters were identified as glandular epithelial cells as determined by their gland-like structure and expression of specific markers. The cell clusters induced significant infiltration of macrophage antigen-2 (Mac-2) positive macrophages by secreting monocyte chemoattractant protein-1 (MCP-1) at the early stage of suction. Subsequently, these infiltrated macrophages expressed massive vascular endothelial growth factor (VEGF) to promoted angiogenesis. Conclusion: EVE generated glandular epithelial cell clusters, which recruited macrophages to promote angiogenesis and subsequent adipose tissue regeneration. These findings shed light on the mechanisms underlying the effects of EVE devices on adipose tissue regeneration.


Assuntos
Tecido Adiposo/fisiologia , Células Epiteliais/citologia , Macrófagos/citologia , Regeneração , Dispositivos para Expansão de Tecidos , Tecido Adiposo/irrigação sanguínea , Tecido Adiposo/citologia , Animais , Células Epiteliais/metabolismo , Macrófagos/metabolismo , Masculino , Neovascularização Fisiológica , Ratos , Ratos Sprague-Dawley , Fator A de Crescimento do Endotélio Vascular/metabolismo
6.
Nan Fang Yi Ke Da Xue Xue Bao ; 38(3): 340-345, 2018 Mar 20.
Artigo em Chinês | MEDLINE | ID: mdl-29643042

RESUMO

OBJECTIVE: To obtain stable primary cultures of human malignant meningioma cells and establish an intracranial in-situ tumor model in nude mice. METHODS: Ten surgical specimens of highly suspected malignant meningioma were obtained with postoperative pathological confirmation. Primary malignant meningioma cells were cultured from the tissues using a modified method and passaged. After identification with cell immunofluorescence, the cultured cells were inoculated into the right parietal lobe of 6 nude mice using stereotaxic apparatus and also transplanted subcutaneously in another 6 nude mice. The nude mice were executed after 6 weeks, and HE staining and immunohistochmistry were used to detect tumor growth and the invasion of the adjacent brain tissues. RESULTS: The primary malignant meningioma cells were cultured successfully, and postoperative pathology reported anaplastic malignant meningioma. Cell immunofluorescence revealed positivity for vimentin and EMA in the cells, which showed a S-shaped growth curve in culture. Flow cytometry revealed a cell percentage in the Q3 area of (95.99∓2.58)%. Six weeks after transplantation, tumor nodules occurred in the subcutaneous tumor group, and the nude mice bearing the in situ tumor showed obvious body weight loss. The xenografts in both groups contained a mean of (36∓5.35)% cells expressing Ki-67, and the intracranial in situ tumor showed obvious invasion of the adjacent peripheral brain tissues. CONCLUSION: We obtained stable primary cultures of malignant meningioma cells and successfully established a nude mouse model bearing in situ human malignant meningioma.


Assuntos
Neoplasias Meníngeas/patologia , Meningioma/patologia , Transplante de Neoplasias , Animais , Humanos , Camundongos , Camundongos Nus , Células Tumorais Cultivadas
7.
Food Chem ; 252: 243-249, 2018 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-29478537

RESUMO

The biochemical properties of buckwheat honey, including contents of sugars, proteins, total phenols, methylglyoxal (MGO), minerals and phenolic compounds, were determined in comparison with those of manuka honey. Buckwheat honey has higher contents of sugars, proteins and total phenols but a lower content of MGO than manuka honey. Buckwheat honey contains abundant minerals involved in a number of vital functions of the human body as does manuka honey, and has even higher contents of Fe, Mn and Zn. In buckwheat honey, p-hydroxybenzoic acid, chlorogenic acid and p-coumaric acid are the dominant phenolic compounds. Moreover, the antibacterial and cellular antioxidant activities of buckwheat honey were compared with those of manuka honey. Buckwheat honey exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, comparable with manuka honey, and the cellular antioxidant activity of buckwheat honey is higher than that of manuka honey. Our results suggest that buckwheat honey has great nutritional and commercial potentials.


Assuntos
Antibacterianos/química , Antibacterianos/farmacologia , Antioxidantes/química , Antioxidantes/farmacologia , Fagopyrum , Mel/análise , Leptospermum , Humanos , Pseudomonas aeruginosa/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos
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