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1.
J Affect Disord ; 296: 189-197, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34607060

RESUMO

BACKGROUND: The symptoms that patients with major depressive disorder (MDD) experience are the dominant contributing factors to its heavy disease burden. This study sought to identify key symptoms leading to disability in patients with MDD. METHODS: Subjects consisted of patients who had a 12-month MDD diagnosis based on the China Mental Health Survey (CMHS). World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess the degree of disability. The associations between depressive symptoms and disability were analyzed using a linear regression and logistic regression with a complex sampling design. RESULTS: Of the 32,552 community residents, 655 patients were diagnosed with 12-month MDD. The disability rate due to MDD was 1.06% (95% CI: 0.85%-1.28%) among adults in Chinese community and 50.7% (95% CI: 44.3%-57.1%) among MDD patients. Depression was associated with all functional losses measured by the WHODAS. Feelings of worthlessness in life or inappropriate guilt, and psychomotor agitation or retardation were the key symptoms related to disability. Economic status, co-morbidity of physical diseases or anxiety disorders were correlates of disability scores. LIMITATIONS: The disability rate might be underestimated due to the exclusion of MDD patients living in hospitals. The effect of treatments on disability was excluded. CONCLUSIONS: Psychological symptoms, not somatic symptoms, contribute to disability in MDD patients. Disability worsens when physical diseases or anxiety disorders are present. More attention could be paid to psychological symptoms, physical diseases, and anxiety disorders in MDD patients with disabilities.

3.
Lancet Psychiatry ; 8(11): 981-990, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34559991

RESUMO

BACKGROUND: In China, depressive disorders have been estimated to be the second leading cause of years lived with disability. However, nationally representative epidemiological data for depressive disorders, in particular use of mental health services by adults with these disorders, are unavailable in China. The present study, part of the China Mental Health Survey, 2012-15, aims to describe the socioeconomic characteristics and the use of mental health services in people with depressive disorders in China. METHODS: The China Mental Health Survey was a cross-sectional epidemiological survey of mental disorders in a multistage clustered-area probability sample of adults of Chinese nationality (≥18 years) from 157 nationwide representative population-based disease surveillance points in 31 provinces across China. Trained investigators interviewed the participants with the Composite International Diagnostic Interview 3.0 to ascertain the presence of lifetime and 12-month depressive disorders according to DSM-IV criteria, including major depressive disorder, dysthymic disorder, and depressive disorder not otherwise specified. Participants with 12-month depressive disorders were asked whether they received any treatment for their emotional problems during the past 12 months and, if so, the specific types of treatment providers. The Sheehan Disability Scale (SDS) was used to assess impairments associated with 12-month depressive symptoms. Data-quality control procedures included logic check by computers, sequential recording check, and phone-call check by the quality controllers, and reinterview check by the psychiatrists. Data were weighted according to the age-sex-residence distribution data from China's 2010 census population survey to adjust for differential probabilities of selection and differential response, as well as to post-stratify the sample to match the population distribution. FINDINGS: 28 140 respondents (12 537 [44·6%] men and 15 603 [55·4%] women) completed the survey between July 22, 2013, and March 5, 2015. Ethnicity data (Han or non-Han) were collected for only a subsample. Prevalence of any depressive disorders was higher in women than men (lifetime prevalence odds ratio [OR] 1·44 [95% CI 1·20-1·72] and 12-month prevalence OR 1·41 [1·12-1·78]), in unemployed people than employed people (lifetime OR 2·38 [95% CI 1·68-3·38] and 12-month OR 2·80 [95% CI 1·88-4·18]), and in people who were separated, widowed, or divorced compared with those who were married or cohabiting (lifetime OR 1·87 [95% CI 1·39-2·51] and 12-month OR 1·85 [95% CI 1·40-2·46]). Overall, 574 (weighted % 75·9%) of 744 people with 12-month depressive disorders had role impairment of any SDS domain: 439 (83·6%) of 534 respondents with major depressive disorder, 207 (79·8%) of 254 respondents with dysthymic disorder, and 122 (59·9%) of 189 respondents with depressive disorder not otherwise specified. Only an estimated 84 (weighted % 9·5%) of 1007 participants with 12-month depressive disorders were treated in any treatment sector: 38 (3·6%) in speciality mental health, 20 (1·5%) in general medical, two (0·3%) in human services, and 21 (2·7%) in complementary and alternative medicine. Only 12 (0·5%) of 1007 participants with depressive disorders were treated adequately. INTERPRETATION: Depressive disorders in China were more prevalent in women than men, unemployed people than employed, and those who were separated, widowed, or divorced than people who were married or cohabiting. Most people with depressive disorders reported social impairment. Treatment rates were very low, and few people received adequate treatment. National programmes are needed to remove barriers to availability, accessibility, and acceptability of care for depression in China. FUNDING: National Health Commission and Ministry of Science and Technology of People's Republic of China. TRANSLATION: For the Chinese translation of the abstract see Supplementary Materials section.


Assuntos
Transtorno Depressivo Maior/epidemiologia , Transtorno Distímico/epidemiologia , Serviços de Saúde Mental/estatística & dados numéricos , Vigilância da População/métodos , Adulto , Distribuição por Idade , Idoso , China/epidemiologia , Estudos Transversais , Transtorno Depressivo Maior/tratamento farmacológico , Manual Diagnóstico e Estatístico de Transtornos Mentais , Transtorno Distímico/tratamento farmacológico , Carga Global da Doença , Humanos , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Distribuição por Sexo , Fatores Socioeconômicos , Inquéritos e Questionários
4.
Insect Sci ; 2021 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-34237799

RESUMO

Vitellogenin receptor (VgR) is crucial for vitellogenin (Vg) uptake by oocytes. VgR is less known in Arachnida, especially in spiders. Different from only one VgR in an arthropod species, two VgRs, VgR-1 and VgR-2, were found in the pond wolf spider, Pardosa pseudoannulata. Both VgRs had the typical domains of the low-density lipoprotein receptor family except for the absence of the ligand-binding domain 1 in VgR-2. Spatiotemporal expression profiles showed that two VgR genes were consistently highly expressed in females and their ovaries, but VgR-1 was 48-fold that of VgR-2 in ovaries. The transcriptional level of VgR-1 was significantly downregulated by RNAi, but it did not work for VgR-2 although several trials were performed. Vg-1 and Vg-2 might be the ligands of VgR-1 because their expressions were also decreased in the dsVgR-1-treated females. Silencing VgR-1 prolonged the pre-oviposition period by 56 h. The expression of VgRs and Vgs were upregulated by juvenile hormones (JHs), which suggested that JHs were the essential factors to vitellogenesis in the spider. The present study revealed the importance of VgR-1 in the spider oviposition, which will improve the understanding on VgR physiological functions in spiders.

5.
Zhongguo Zhong Yao Za Zhi ; 46(7): 1717-1726, 2021 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-33982475

RESUMO

Diaporthe sp. fungi is one of the important sources of active natural products. Polyketides, alkaloids, terpenes, anthraquinones and other types of novel metabolic products are found from this genus, and many of them have significant anti-tumor, antibacterial, anti-hyperlipidemia, inhibition of pulmonary fibrosis, antioxidant and other biological activities. This paper reviewed source, structure and biological activity of natural products from Diaporthe sp. in the past two decades, and provided a reference for in-depth study of natural product of this genus fungus and innovative drug development.


Assuntos
Produtos Biológicos , Policetídeos , Antibacterianos , Produtos Biológicos/farmacologia , Fungos , Terpenos
6.
J Environ Manage ; 280: 111674, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33218830

RESUMO

Constructed wetlands (CWs), known as an alternative clean technology, have been widely used for sewage treatment. However, greenhouse gas (N2O, CH4 and CO2) emissions are the accompanying problem in CWs. To mitigate the net global warming potential (GWP) with the constant removal efficiency for contaminants is attracting wide attention recently. In this study, four CWs were established to explore the effects of substrate types (gravel, walnut shell, manganese ore and activated alumina) on contaminant removal and greenhouse gas emissions. CWs using manganese ore substrate with function of electronic exchange showed high removal efficiencies on COD (90.1%), TN (65.1%), TP (97.1%) and low greenhouse gas flux. The emission fluxes of N2O, CH4 and CO2 were 0.07-0.20, 2.00-252.30 and 337.54-782.57 mg m-2 h-1, respectively. Especially, the lowest average CH4 emission flux in the manganese ore CW was only 2.00 mg m-2 h-1 while those of N2O in walnut shell CW was only 0.07 mg m-2 h-1, which will make a significant contribution on the mitigation of GWP of CWs. High-throughput sequencing results indicated that microbial community diversity and richness changed significantly among different substrates. The high pmoA and low mcrA, caused by the introduction of manganese ore as substrate, also explained why there was little CH4 emission in CWs. Our study provided new insights into GWP mitigation and contaminant removal enhancement in CWs using optimal substrate.


Assuntos
Poluentes Ambientais , Gases de Efeito Estufa , Gases de Efeito Estufa/análise , Metano/análise , Óxido Nitroso/análise , Áreas Alagadas
7.
J Sep Sci ; 44(5): 992-1004, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33352011

RESUMO

The Lilium lancifolium Thunb. is a herb with multiple functions in both medicine and food in China, and its extracts have shown antidepressant effects. In this study, fresh bulbs of Lilium lancifolium Thunb. were processed to study the effects of different drying processes on changes in its main chemical components. We found that different drying methods can affect the chemical constituents of the herb. Among these components, Regaloside A has been found as the characteristic component. Here, Cell Counting Kit-8 assay, and Western blotting were used to evaluate the neuroprotective antidepressant effects of Regaloside A. The results showed the cell survival rate was improved, the phosphorylation levels of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphatidylinositol 3 kinase, protein kinase B, and mammalian target of rapamycin were increased after Regaloside A treatment. In general, different drying methods have a significant influence on the chemical composition of the herb, and Regaloside A may be the main chemical component of the herb. It can alleviate the damage of corticosterone in SH-SY5Y cells, and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling mediated by brain-derived neurotrophic factor/tyrosine kinase receptor B may play an important role in the neuroprotective antidepressant effects of Regaloside A.


Assuntos
Antidepressivos/farmacologia , Dessecação , Lilium/química , Extratos Vegetais/farmacologia , Antidepressivos/química , Antidepressivos/isolamento & purificação , Sobrevivência Celular/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Corticosterona , Humanos , Espectrometria de Massas , Simulação de Acoplamento Molecular , Estrutura Molecular , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Células Tumorais Cultivadas
8.
Orthop Surg ; 12(6): 1710-1717, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33000562

RESUMO

OBJECTIVE: To investigate the biomechanical effects of different insertion angles of absorbable screws for the fixation of radial head fractures. METHODS: The finite element models used to simulate the fractures were created based on CT scans. Two absorbable screws were used to fix and maintain the stability of the fracture, and the angles between the screws were set to 0°, 15°, 30°, 45°, 60°, 75°, and 90°. A downward force of 100 N was applied at the stress point, which was coupled with the surface, and the distal radius was limited to six degrees of freedom. The direction and location of the applied force were the same in each model. The values of the von Mises stress and peak displacements were calculated. RESULTS: Under the applied load and different screw angles, the maximum von Mises stress in the screws was concentrated on the surface contacting the fracture surfaces. The maximum von Mises equivalent stress in the screw decreased when the angle increased from 0° (19.54 MPa) to 45° (13.11 MPa) and increased when the angle further increased to 90° (24.63 MPa). The peak displacement decreased as the angle increased from 0° (0.19 mm) to 45° (0.15 mm) and increased when the angle further increased to 90° (0.25 mm). CONCLUSION: The computational stress distribution showed that fixation with absorbable screws is safe for patients. Moreover, the minimum von Mises stress and displacements were generated when the angle between the screws was 45°; hence, this setting should be recommended for Mason type II radial fractures.


Assuntos
Parafusos Ósseos , Fixação Interna de Fraturas/instrumentação , Fraturas do Rádio/cirurgia , Implantes Absorvíveis , Adulto , Fenômenos Biomecânicos , Análise de Elementos Finitos , Fixação Interna de Fraturas/métodos , Humanos , Masculino , Fraturas do Rádio/diagnóstico por imagem
9.
Onco Targets Ther ; 13: 6661-6673, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32764958

RESUMO

Purpose: Evidence indicates that the actin-binding protein Coronin 3, which is aberrantly expressed in various cancers, is associated with cancer development and progression. However, little is known about the role of Coronin 3 in glioma tumorigenesis. Here, we aimed to explore the biological function and regulatory mechanism of Coronin 3 in glioblastoma (GBM). Materials and Methods: Coronin 3 level in human GBM clinical samples and cell lines was investigated. The shRNA knockdown strategy was used to assess the tumor characteristics of GBM cell lines. The role of ß-catenin in Coronin 3-mediated oncogenic phenotypes was evaluated. Results: Coronin 3 was found to be highly upregulated in glioma cell lines. Furthermore, knockdown of Coronin 3 significantly inhibited the growth of glioma cells both in vivo and in vitro and suppressed the expression of Wnt/ß-catenin pathway genes, including ß-catenin, Cyclin D1, and c-Myc. Moreover, we demonstrated that Coronin 3 regulates the expression of ß-catenin in glioma. Our results revealed that Coronin 3-stimulated tumor growth was ß-catenin-dependent. Conclusion: Our study reveals a new molecular mechanism of Coronin 3 in promoting glioma growth and development through regulating the Wnt/ß-catenin signaling pathway.

10.
Phytochemistry ; 179: 112500, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32862046

RESUMO

Six flavonoid glycosides jixueqisus A-F, together with nine known flavonoids, were isolated from the rhizomes of the fern Pronephrium penangianum. Among them, two red pigments jixueqisus A and B possess the same rare 6,8-dimethyl-2-phenyl-7H-1-benzopyran-7-one skeleton (a long conjugated system). Jixueqisu Cwas a dihydrochalcone glycoside, jixueqisu D was a chalcone glycoside, jixueqisu E was an aurone glycoside, and jixueqisu F was a flavonone glycoside. Interestingly, jixueqisus D-F, (2S)-5,2',5'-trihydroxy-7-methoxyflavanone and 5,2',5'-trihydroxy-7-methoxyflavone possessed a 2,5-dihydroxy substituted benzene ring (B-ring). Their structures were elucidated by various spectroscopic and chemical methods. Furthermore, the plausible biosynthetic pathways of jixueqisus A-F were discussed, respectively. All isolated compounds were evaluated for their activities against the proliferation of MCF-7, HepG-2, HCT-116 and BGC-823 tumor cell lines, four known flavane-4-ol glycosides, abacopterins A and C, eruberin B and triphyllin A, exhibited moderate activities to various cell lines.


Assuntos
Medicamentos de Ervas Chinesas , Gleiquênias , Flavonoides , Glicosídeos , Estrutura Molecular , Rizoma
11.
J Med Internet Res ; 22(7): e14915, 2020 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-32716301

RESUMO

BACKGROUND: Smartphones have become ubiquitous in China, offering a promising way to deliver mental health interventions; however, little is known about the current use and characteristics of smartphone apps for mental health. OBJECTIVE: The purpose of this study was to gain insight into mobile mental health apps available in China as of December 2018. METHODS: A systematic search was conducted to identify and evaluate the most downloaded apps from iOS and Android platforms. Apps were categorized according to their main purpose and downloaded to evaluate their content. Each app's affiliation, cost, target users, information security, and evidence-based nature were evaluated. RESULTS: Of the 172 unique apps that were identified, there were 37 apps (21.5%) for psychological counseling, 50 apps (29.1%) for assessment, 12 apps (7.0%) to relieve stress, 24 apps (14.0%) for psychoeducation, and 49 (28.4%) multipurpose apps (ie, a combination of counseling and assessment). Most apps were developed for adults in the general population (166/172, 96.5%), rather than for psychiatric patients. App-based counseling was mostly provided by psychologists, and of the assessed apps, only 40% (70/172) used evidence-based scales to assess mental health problems such as anxiety or depressed mood. Guided meditation was used as the main technique in stress-relieving apps. CONCLUSIONS: Many apps contained useful and evidence-based elements, such as good quality information, validated measurements, and useful meditation methods; however, for mobile apps to contribute significantly to mental health care in China, considerable challenges remain, including the need for more patient-focused apps that can actually take on the role of a health care provider. In addition, efficacy studies are needed.


Assuntos
Saúde Mental/normas , Aplicativos Móveis/normas , Smartphone/normas , Humanos
12.
BMC Psychiatry ; 20(1): 323, 2020 06 22.
Artigo em Inglês | MEDLINE | ID: mdl-32571270

RESUMO

BACKGROUND: Little is known about the public stigma on mental illness and mental health knowledge (MHK) in China, public stigma and low MHK can negatively affect patients' health and increase the burden of mental disorders on society. This study aimed at investigating the rates of stigma and MHK, the correlates of stigma and MHK, and the association between MHK and stigma among a Chinese population. METHODS: The data is from the Tianjin Mental Health Survey (TJMHS), which involved a large and a representative sample of adult community residents in the Chinese municipality of Tianjin (n = 11,748). In a 12% random subsample (n = 1775) the Perceived Discrimination and Devaluation scale (PDD) and a Mental Health Knowledge Questionnaire (MHKQ) were administered. First, percentages of the responses to the individual items of the PDD and MHKQ were investigated. Second, sociodemographic correlates of PDD and MHK, and the association between stigma and MHK were investigated. RESULTS: We found that a sizable proportion of participants responded that others would hold a negative attitude towards (former) mental patients, especially with regard to engaging in closer personal relationships. Most people were not familiar about the causes, treatments and prevention of mental illness. Resident area, age, education level, Per capita family income and employment status were related to devaluation score and MHKQ score. MHK was negatively associated with public stigma. CONCLUSIONS: There is room for improvement with regard to levels of public stigma and MHK in China. Providing psychoeducation to improve public MHK could also contribute to reduction of public stigma.


Assuntos
Grupo com Ancestrais do Continente Asiático/psicologia , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Transtornos Mentais/psicologia , Saúde Mental/estatística & dados numéricos , Estigma Social , Adulto , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Transtornos Mentais/epidemiologia , Transtornos Mentais/etnologia , Inquéritos e Questionários
13.
Materials (Basel) ; 13(7)2020 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-32268532

RESUMO

The main purpose of this present study was to investigate the different processing conditions on the microstructure, segregation behavior of alloying elements, and mechanical properties of Al-Mg-Si alloy twin-roll cast slab prepared using a novel twin-roll casting technology. The simulation of temperature field, distribution of alloying elements, tensile properties, hardness, and conductivity were examined by a Leica optical microscope, scanning electron microscopy, energy dispersion spectroscopy, electron probe microanalysis, and tensile tests. The results indicated that when the traditional twin-roll casting method was used to produce aluminum alloy strip, there are obvious centerline segregation defects due to the deep crystallization front depth and symmetrical solidification characteristics. When the forced-cooling technology was applied in the twin-roll casting process, by virtue of the changing of crystallization front depth and crystallization front shape, the segregation defects are obviously suppressed. Suggesting that this method can significantly improve the uniformity of alloying elements in the thickness direction of the twin-roll cast slab, ultimately improve the mechanical properties of AA6022 aluminum alloy.

14.
Bioresour Technol ; 309: 123358, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32315916

RESUMO

The performance of eological floating bed (EFB) with novel carbon source (CS) and reed biochar substrate (RBS) derived from reed straw (RS) was evaluated for the advanced treatment of effluent from wastewater treatment plants (WWTPs). The average carbon releasing capacity of CS was 4.50 mg/g, and the P adsorption capacity of RBS was 0.39 mg/g. The additional CS and RBS increased the average removal efficiencies of total nitrogen (TN) and total phosphorus (TP) by 57.6% and 46.7%, respectively. Furthermore, the high-throughput sequencing results revealed significantly different microbial species richness and diversity due to the CS and RBS. Some genera related to nitrogen removal, such as Pseudomonas, Rhodobacter, Hydrogenophaga, Bradyrhizobium, Acinetobacter and Thiobacillus, were enriched in the EFB with CS and RBS. This study provided a suitable method for effectively treating low C/N wastewater such as WWTPs effluent using EFB strengthened by processed wetland plant.


Assuntos
Fósforo , Águas Residuárias , Carbono , Nitrogênio , Eliminação de Resíduos Líquidos , Áreas Alagadas
15.
Bioorg Chem ; 96: 103646, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32036160

RESUMO

Three new compounds, including two new 3,4,6-trisubstituted α-pyrone derivatives, chrysopyrones A and B (1 and 2), and one new indolyl diketopiperazine derivative, penilline C (3), along with twelve known compounds (4-15), were isolated and identified from the fungus Penicillium chrysogenum SCSIO 07007, separated from deep-sea hydrothermal vent environment sample collected from the Western Atlantic. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All of the isolated compounds (1-15) were evaluated for their cytotoxic, antibacterial activities and enzyme inhibitory activities against acetylcholinesterase (AChE), α-glycosidase, and protein tyrosine phosphatase 1B (PTP1B). Among them, new compounds chrysopyrones A and B (1 and 2) displayed obvious inhibitory activities against PTP1B with IC50 values of 9.32 and 27.8 µg/mL, respectively. Furthermore, molecular docking was performed to investigate the inside perspective of the action in PTP1B enzyme.


Assuntos
Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Penicillium chrysogenum/química , Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Inibidores Enzimáticos/isolamento & purificação , Humanos , Simulação de Acoplamento Molecular , Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo , Pironas/química , Pironas/isolamento & purificação , Pironas/farmacologia
16.
J Affect Disord ; 260: 334-341, 2020 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-31521871

RESUMO

BACKGROUND: To investigate mental and physical health comorbidity with chronic back or neck pain in the Chinese population, and assess the level of disability associated with chronic back or neck pain. METHODS: Data were derived from a large-scale and nationally representative community survey of adult respondents on mental health disorders in China (n = 28,140). Chronic back or neck pain, other chronic pain conditions and chronic physical conditions were assessed by self-report. Mental disorders were assessed by the Composite International Diagnostic Interview (CIDI). Role disability during the past 30 days was assessed with the World Health Organization Disability Assessment Schedule (WHO-DAS-II). RESULTS: The 12-month prevalence of chronic back or neck pain was 10.8%. Most of respondents with chronic back or neck pain (71.2%) reported at least one other comorbid condition, including other chronic pain conditions (53.4%), chronic physical conditions (37.9%), and mental disorders (23.9%). It was found by logistic regression that mood disorders (OR = 3.7, 95%CI:2.8-4.8) showed stronger association with chronic back or neck pain than anxiety disorders and substance disorders. Most common chronic pains and physical conditions were significantly associated with chronic back or neck pain. Chronic back or neck pain was associated with role disability after controlling for demographics and for comorbidities. Physical and mental comorbidities explained 0.7% of the association between chronic back or neck pain and role disability. CONCLUSIONS: Chronic back or neck pain and physical-mental comorbidity is very common in China and chronic back or neck pain may increase the likelihood of other physical and mental diseases. This presents a great challenge for both clinical treatment and public health education. We believe that further study needs to be conducted to improve the diagnostic and management skills for comorbidity conditions.


Assuntos
Dor Crônica/epidemiologia , Transtornos Mentais/epidemiologia , Cervicalgia/epidemiologia , Adolescente , Adulto , Idoso , China/epidemiologia , Doença Crônica , Dor Crônica/psicologia , Comorbidade , Feminino , Inquéritos Epidemiológicos , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Cervicalgia/psicologia , Prevalência , Autorrelato , Inquéritos e Questionários , Adulto Jovem
17.
Arch Gerontol Geriatr ; 87: 103968, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31751901

RESUMO

Little was known about sleep quality among Chinese population. Using data from a population-based survey, we aimed to describe the prevalence of poor sleep quality among Chinese elderly people, to analyze factors associated with poor sleep quality, and to explore the relation between sleep quality and life quality as well as the risk for mental disorders. Data was derived from the Tianjin Mental Health Survey. The 19-item Pittsburg Sleep Quality Index was used to assess sleep quality. Life quality was evaluated using a Chinese version of Quality of Life Scale. To investigate the risk for mental disorders, the Chinese version of General Health Questionnaire was administered. Female gender, older age, low educational attainment, poor subject family economic status, and not having health insurance were significantly associated with elevated risk of poor sleep quality. Poor sleep quality was associated with poor life quality and increased odds of mental disorders. Further studies are warranted for the evaluation of effectiveness of screening tools for sleep problems and the generalization of early screening and diagnosing programs in the nation. Early screening is necessary and appropriate intervention programs should be conducted in the population with high risk.


Assuntos
Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , Transtornos Mentais/psicologia , Qualidade de Vida/psicologia , Transtornos do Sono-Vigília/epidemiologia , Sono/fisiologia , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Transtornos Mentais/epidemiologia , Pessoa de Meia-Idade , Vigilância da População , Prevalência , Distúrbios do Início e da Manutenção do Sono , Fatores Socioeconômicos , Inquéritos e Questionários
18.
BMC Psychiatry ; 19(1): 373, 2019 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-31783825

RESUMO

BACKGROUND: Failure to seek treatment for mental health disorders is a serious public health concern. Unfortunately, there is little insight into help-seeking and its associated factors in China which has undergone rapid economic development in the past 30 years and has an increasing prevalence of mental disorder. Therefore, this study aimed to (1) investigate help-seeking rates in healthcare and non-healthcare settings and (2) investigate the correlates of help-seeking behavior in a large Chinese survey. METHODS: Data came from the Tianjin Mental Health Survey (TJMHS), a representative sample of adult community residents in the Chinese municipality of Tianjin (n = 11,748). Of these, 1759 individuals had ≥1 axis-I diagnosis according to the Diagnostic and Statistical manual- fourth edition (DSM-IV) and were administered a Help-Seeking Questionnaire. RESULTS: 15.7% of patients reported that they had ever sought help during their entire lifetime before the interview, with 4.5% seeking help in mental healthcare, 3.2% in other healthcare and 8.1% in non-healthcare settings (e.g., family, friends, and spiritual advisor). Among help-seekers, the first help was mostly sought in non-healthcare settings (58.4%), followed by healthcare (27.5%) and mental healthcare settings (24.5%). Female gender, younger age, having 7-9 years vs 0-6 years of education, a low income, a psychotic disorder and having ≥2 disorders were associated with increased help-seeking. Older age, being married and having a psychotic or organic disorder were associated with increased help-seeking in healthcare vs. non-healthcare settings. CONCLUSION: A small percentage of persons with mental disorders in the Tianjin region seek help and among those who do, variations in the types of help-seeking may be partially explained by demographic and clinical characteristics.


Assuntos
Família , Amigos , Conhecimentos, Atitudes e Prática em Saúde , Serviços de Saúde , Comportamento de Busca de Ajuda , Internet , Transtornos Mentais/terapia , Serviços de Saúde Mental , Adolescente , Adulto , Fatores Etários , China/epidemiologia , Estudos Transversais , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Linhas Diretas , Humanos , Masculino , Transtornos Mentais/epidemiologia , Pessoa de Meia-Idade , Aceitação pelo Paciente de Cuidados de Saúde , Prevalência , Qigong , Fatores Sexuais , Discriminação Social , Estigma Social , Inquéritos e Questionários , Adulto Jovem
19.
Materials (Basel) ; 12(21)2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31683621

RESUMO

The quenching rate of Al-Mg-Si alloys during solution treatment is an important parameter for the automotive industry. In this work, the effect of the different quenching rates on the microstructures, mechanical properties, and paint bake-hardening response of Al-Mg-Si sheets was studied. Large dimples form on the fracture surface of a sample at a quenching rate of 0.01 °C/s. When the quenching rate increased to 58.9 °C/s, the dimples became smaller. The recrystallized grains and textures were slightly affected by quenching rates beyond 1.9 °C/s. Thus, higher r values of the samples were achieved with slower quenching rates. Furthermore, only the Al(FeMn)SiCr insoluble phases were observed in samples with a rapid quenching rate. Sufficient solute atoms and vacancies resulted in the improvement of the precipitation kinetics and paint bake-hardening capacity for Al-Mg-Si sheets at rapid rates. With a decrease in the quenching rate, the formation of the rod-like coarse ß' phases consumed many solute atoms and vacancies, leading to the deterioration of the paint bake-hardening capacity. This study provides a critical reference on quenching rates for industrial practices, so that good mechanical properties can be achieved using precision control of the quenching process.

20.
J Zhejiang Univ Sci B ; 20(11): 865-867, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31595722

RESUMO

Positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and "real-time" monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008). The development of molecular probes bearing short-lived positron-emitting radionuclides, such as 18F (half-life 110 min) or 11C (half-life 20 min), is crucial for PET imaging to collect in vivo metabolic information in a time-efficient manner (Deng et al., 2019). In this regard, one of the main challenges is rapid synthesis of radiolabeled probes by introducing the radionuclides into pharmaceuticals as soon as possible before injection for a PET scan. Although many potential PET probes have been discovered, only a handful can satisfy the demand for a highly efficient synthesis procedure that achieves radiolabeling and delivery for imaging within 1-2 radioisotope half-lives. Only a few probes, such as 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) and [18F]fluorodopa, are routinely produced on a commercial scale for daily clinical diagnosis (Grayson et al., 2018; Carollo et al., 2019).


Assuntos
Dispositivos Lab-On-A-Chip , Tomografia por Emissão de Pósitrons/métodos , Radioisótopos/química , Compostos Radiofarmacêuticos/síntese química , Extração em Fase Sólida
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