Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 711
Filtrar
1.
ACS Sens ; 8(1): 388-396, 2023 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-36617720

RESUMO

Herein, a fluorescence and surface-enhanced Raman spectroscopy dual-mode system was designed for cholesterol detection based on self-assembled plasmonic nanojunctions mediated by the competition of rhodamine 6G (R6G) and cholesterol with ß-cyclodextrin modified on gold nanoparticles (HS-ß-CD@Au). The fluorescence of R6G was quenched by HS-ß-CD@Au due to the fluorescence resonance energy transfer effect. When cholesterol was introduced as the competitive guest, R6G in the cavities of HS-ß-CD@Au was displaced to recover its fluorescence. Moreover, two of HS-ß-CD@Au can be linked by one cholesterol to form a more stable 2:1 complex, and then, plasmonic nanojunctions were generated, which resulted in the increasing SERS signal of R6G. In addition, fluorescence and SERS intensity of R6G increased linearly with the increase in the cholesterol concentrations with the limits of detection of 95 and 74 nM, respectively. Furthermore, the dual-mode strategy can realize the reliable and sensitive detection of cholesterol in the serum with good accuracy, and two sets of data can mutually validate each other, which demonstrated great application prospects in the surveillance of diseases related with cholesterol.

2.
J Hepatocell Carcinoma ; 10: 27-42, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36660411

RESUMO

Purpose: To identify disease-specific profiles comprising patient characteristics and imaging biomarkers on contrast-enhanced (CE)-computed tomography (CT) that enable the non-invasive prediction of the hepatopulmonary shunt fraction (HPSF) in patients with hepatocellular carcinoma (HCC) before resin-based transarterial radioembolization (TARE). Patients and Methods: This institutional review board-approved (EA2/071/19) retrospective study included 56 patients with HCC recommended for TARE. All patients received tri-phasic CE-CT within 6 weeks prior to an angiographic TARE evaluation study using technetium-99m macroaggregated albumin. Imaging biomarkers representative of tumor extent, morphology, and perfusion, as well as disease-specific clinical parameters, were used to perform data-driven variable selection with backward elimination to generate multivariable linear regression models predictive of HPSF. Results were used to create clinically applicable risk scores for patients scheduled for TARE. Additionally, Cox regression was used to identify independent risk factors for poor overall survival (OS). Results: Mean HPSF was 13.11% ± 7.6% (range: 2.8- 35.97%). Index tumor diameter (p = 0.014) or volume (p = 0.034) in combination with index tumor non-rim arterial phase enhancement (APHE) (p < 0.001) and washout (p < 0.001) were identified as significant non-invasive predictors of HPSF on CE-CT. Specifically, the prediction models revealed that the HPSF increased with index lesion diameter or volume and showed higher HPSF if non-rim APHE was present. In contrast, index tumor washout was associated with decreased HPSF levels. Independent risk factors of poorer OS were radiogenomic venous invasion and ascites at baseline. Conclusion: The featured prediction models can be used for the initial non-invasive estimation of HPSF in patients with HCC before TARE to assist in clinical treatment evaluation while potentially sparing ineligible patients from the angiographic shunt evaluation study.

3.
J Biomol Struct Dyn ; : 1-7, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36625725

RESUMO

To measure the expression of angiotensin converting enzyme 2 (ACE2) mRNA in SARS-CoV-2 infection with different infection status and at different stages during infection, we used RT-qP CR to measure the expression of ACE2 mRNA. Measurements were analyzed by two-way repeated measures analysis of variance (RMANOVA). Expression of ACE2 mRNA was downregulated in initial stages of SARS-CoV-2 infection both in the asymptomatic infection (ASY) group and the confirmed cases (CON) group (t=-8.0845, P < 0.0001; t=-8.1904, P < 0.0001, respectively). The expression of ACE2 mRNA in the incubation period of CON group was lower compared with the intinal period of ASY group (F = 6.084, p = 0.016, partialη2 = 0.070). Relative expression of ACE2 mRNA was upregulated at the late stage of SARS-CoV-2 infection in the ASY and CON groups (F = 23.489, p = 0.000, partialη2 = 0.225; F = 46.555, p = 0.000, partialη2 = 0.365, respectively). The relative expression of ACE2 mRNA was down-regulated (mean ± SEM:0.69 ± 0.03) after inoculation with SARSCoV- 2 Spike pseudovirus, and there was a statistical difference (one-way t test, mean diffience =-0.31, 95%CI: -0.37˜-0.24, t=-8.1904, P < 0.0001). The expression of ACE2 mRNA is downregulated in the initial stage of SARS-CoV-2 infection, and then upregulated in the late stage of SARS-CoV-2 infection. The lower expression of ACE2 mRNA during the incubation period can lead to clinical symptoms. Downregulation of ACE2 mRNA was related to the interaction between SARS-CoV-2 S protein and ACE2.Communicated by Ramaswamy H. Sarma.

4.
Mol Psychiatry ; 2023 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-36690791

RESUMO

The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74-/- mice showed autism- and anxiety-like behaviors along with increased excitability of pyramidal neurons (PNs) in the prelimbic cortex (PL), which were reversed by Tmem74 re-expression and chemogenetic inhibition in PNs of the PL. To determine the underlying circuitry, we performed conditional deletion of Tmem74 in the PNs of PL of mice, and we found that alterations in the PL projections to fast-spiking interneurons (FSIs) in the dorsal striatum (dSTR) (PLPNs-dSTRFSIs) mediated the hyperexcitability of FSIs and autism-like behaviors and that alterations in the PL projections to the PNs of the basolateral amygdaloid nucleus (BLA) (PLPNs-BLAPNs) mediated the hyperexcitability of PNs and anxiety-like behaviors. However, the two populations of PNs in the PL had different spatial locations, optogenetic manipulations revealed that alterations in the activity in the PL-dSTR or PL-BLA circuits led to autism- or anxiety-like behaviors, respectively. Collectively, these findings highlight that the hyperactivity of the two populations of PNs in the PL mediates autism and anxiety comorbidity through the PL-dSTR and PL-BLA circuits, which may lead to the development of new therapeutics for the autism and anxiety comorbidity.

5.
Curr Eye Res ; : 1-7, 2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36601653

RESUMO

PURPOSE: To evaluate the associations between calcium, magnesium, zinc, and copper intakes and the risk of diabetic retinopathy (DR) in US diabetes adults. METHODS: Using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Multivariable logistic regression models and restricted cubic spline models were applied to examine the associations between total calcium, magnesium, zinc, and copper intakes and diabetic retinopathy. RESULTS: A total of 3794 adults aged 40 years or older were included. Higher quartile intake of calcium, magnesium, zinc, and copper was associated with a lower occurrence of DR, the multivariate adjusted ORs (95% CI) were 0.57 (0.38-0.86), 0.48 (0.32-0.73), 0.58 (0.39-0.88), and 0.48 (0.30-0.77), respectively. U-shaped dose-response relationships were found between calcium, magnesium, zinc, copper intake, and the risk of DR. CONCLUSION: Higher total calcium, magnesium, zinc, and copper intake were inversely associated with the risk of DR in US diabetes adults.

6.
Neuroscience ; 510: 72-81, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36572173

RESUMO

Social anxiety is characterized by an intense fear of evaluation from others and/or withdrawal from social situations. Extreme social anxiety can lead to social anxiety disorder. There remains an urgent need to investigate the neural substrates of subclinical social anxiety for early diagnosis and intervention to reduce the risk to develop social anxiety disorder. Twenty-nine young adults were recruited (10 males/19 females; mean age (SD) = 20.34 (2.29)). Trait-like social anxiety was assessed by Liebowitz Social Anxiety Scale. Functional magnetic resonance imaging was used with an emotional face-matching paradigm to probe brain activation in response to emotional stimuli including angry, fearful, and happy faces, with shape-matching as a control condition. Behavioral results showed positive correlations between Liebowitz Social Anxiety Scale scores and the reaction time in both angry and fearful conditions. The activation of superficial amygdala and the deactivation of basal forebrain in response to angry condition showed positive correlations with the level of social anxiety. In addition, the resting-state functional connectivity between these two regions was negatively correlated with the level of social anxiety. These results may help to understand the individual difference and corresponding neural underpinnings of social anxiety in the subclinical population, and might provide some insight to develop strategies for early diagnosis and interventions of social anxiety to reduce the risk of deterioration from subclinical to clinical level of social anxiety.

7.
Chem Commun (Camb) ; 59(3): 346-349, 2023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-36514971

RESUMO

The designed synthesis of chiral luminescent molecules with excellent circularly polarized luminescence (CPL) performance and high quantum yield (QY) levels has attracted great interest but remains very challenging. Herein, we report three pairs of chiral europium-titanium-oxo clusters featuring both modest CPL characteristics and high QY levels (up to 79%), which can be regulated by switching between different ligand substituents.


Assuntos
Európio , Titânio , Luminescência
8.
Inorg Chem ; 2022 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-36459444

RESUMO

Hybrid organic-inorganic halide perovskites (HOIPs) have received continued interest for their structure diversity and potential application in optoelectronic, solar cells, nonlinear optics (NLO), and ferroelectrics. Structural symmetry breaking induced by water molecules in single-crystal-to-single-crystal (SCSC) transformations is beneficial to develop ferroelectrics or second-harmonic generation (SHG) materials. Along this line, a water-containing two-dimensional (2D) double perovskite, (C6H16N2)2AgBiBr8·H2O (1), was prepared. Acentric 1 suffered a twice SCSC transformation when subjected to dehydration and rehydration, where the new centric (C6H16N2)2AgBiBr8 (2) and acentric (C6H16N2)2AgBiBr8·0.5H2O (3) were generated. In contrast to the irreversible transformation from 1 to 2 (symmetry: P21 → Pmna), it is prominent that the reversible conversion of centric 2 to acentric 3 (symmetry: Pmna ↔ P21212). The result validated the effect of guest water on inducing structural transformation and symmetry breaking of 2D perovskites, inspiring further explorations on water-involved 2D materials.

9.
J Comput Soc Sci ; : 1-39, 2022 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-36465148

RESUMO

For a healthy society to exist, it is crucial for the media to focus on disease-related issues so that more people are widely aware of them and reduce health risks. Recently, deep neural networks have become a popular tool for textual sentiment analysis, which can provide valuable insights and real-time monitoring and analysis regarding health issues. In this paper, as part of an effort to develop an effective model that can elicit public sentiment on COVID-19 news, we propose a novel approach Cov-Att-BiLSTM for sentiment analysis of COVID-19 news headlines using deep neural networks. We integrate attention mechanisms, embedding techniques, and semantic level data labeling into the prediction process to enhance the accuracy. To evaluate the proposed approach, we compared it to several deep and machine learning classifiers using various metrics of categorization efficiency and prediction quality, and the experimental results demonstrate its superiority with 0.931 testing accuracy. Furthermore, 73,138 pandemic-related tweets posted on six global channels were analyzed by the proposed approach, which accurately reflects global coverage of COVID-19 news and vaccination.

10.
RSC Adv ; 12(55): 36018-36027, 2022 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-36545106

RESUMO

To provide low-cost wax and a new methodology for utilizing waste cooking oil (WCO), fatty acid wax based on WCO was synthesized by using epoxidation and hydrolysis treatments, whose properties included melting point, color, hardness, combustion properties, aldehyde content, and microscopic morphology were tested and analyzed. The obtained WCO-based wax contained mixed fatty acids, including palmitic acid and 9,10-dihydroxystearic acid as main constituents, which could form a 3D stable crossing network constructed by large long-rod crystals. The WCO-based wax with high fatty acid content (96.41 wt%) has a high melting point (44-53 °C), light color (Lovibond color code Y = 11.9, R = 2.3), good hardness (needle penetration index = 2.66 mm), long candle burning time (293 min), and low aldehyde content (7.98 × 10-2 µg g-1), which could be a lower-cost alternative of commercial soybean wax (SW) for producing various wax products including candles, crayons, waxworks, etc.

11.
Polymers (Basel) ; 14(24)2022 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-36559779

RESUMO

Mass customization is the development of items tailored to specific customers, but produced at low unit cost in high-volume. In this context, hybrid manufacturing (HM) combines fused deposition modeling (FDM) and injection molding (IM) to fabricate a single personalized part with minimum manufacturing cost. In this technique, inserts with different physical features are first FDM-fabricated and then IM-overmolded. This study investigated the effect of hybrid FDM-IM production technology, FDM insert geometry on mechanical properties, and micro-structural evolution of Polylactic Acid (PLA) samples. The findings indicated a comparable tensile properties of FDM-IM samples (68.38 MPa) to IM batch (68.95 MPa), emphasizing the potential of HM in the manufacturing industry. Maximum tensile stress of FDM-IM specimens shows an upward trend due to the increased infill density of preforms. In addition, overmolding interface direction results in a big gap for the maximum tensile strengths between half-length series specimens (12.99 MPa to 19.09 MPa) and half-thickness series specimens (53.83 MPa to 59.92 MPa). Furthermore, four joint configurations resulted in different mechanical performances of finished specimens, in which the female cube sample exhibits the highest tensile stress (68.38 MPa), while the batch with male T joint shows a lower value in maximum tensile strength (59.51 MPa), exhibiting a similar tensile performance with the half-thickness 75% batch without joint configuration. This study lays the groundwork for using HM to produce bespoke and mechanically improved parts over FDM alone.

12.
Artigo em Inglês | MEDLINE | ID: mdl-36575687

RESUMO

Purpose: To explore the efficacy, safety, and potential factors influencing efficacy and outcome of pyrotinib-based therapy in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) in complex clinical practice. Methods: Real-world data for HER2-positive MBC patients treated with pyrotinib-based regimens from 6 hospitals in Northern Anhui, China, from September 2018 to February 2022, were retrospectively collected, and clinicopathological features, efficacy, prognosis, and safety were analyzed. Potential influencing factors including baseline serum vascular endothelial growth factor-A (VEGF-A) for evaluating pyrotinib's treatment response and outcome were also explored. Results: A total of 169 patients with HER2-positive MBC were enrolled. The objective response rate (ORR), disease control rate (DCR), and median progression-free survival (mPFS) of the overall cohort were 65.1%, 87.6%, and 12.4 months, respectively. Pyrotinib is highly beneficial as different treatment lines and appears to be a feasible strategy both in combination with chemotherapeutic drugs and alone. The mPFS values were 16.5 months, 12.4 months, and 9.3 months in the first, second, and third-or-higher lines of anti-HER2 therapy, respectively (P=0.027). The most common adverse event (AE) was diarrhea (88.2%), and patients with < grade 3 diarrhea achieved a longer mPFS than patients with ≥ grade 3 diarrhea (13.3 months vs 6.9 months, P=0.007). Among the patients with available baseline VEGF-A data, the ORR was 43.5% in patients with a high level of VEGF-A, compared to 81.5% in patients with a low level of VEGF-A (P=0.005). Moreover, patients in the VEGF-A-high group exhibited a shorter mPFS time than those in the VEGF-A-low group (7.8 months vs 19.1 months, P=0.004). Further analysis demonstrated AE of diarrhea and VEGF-A at baseline to be independent prognostic factors for PFS. Conclusion: Pyrotinib-based regimens showed promising efficacy, with manageable tolerance, and AE occurrence of severe diarrhea and baseline level of serum VEGF-A are helpful in predicting the treatment outcome of pyrotinib in HER2-positive MBC.

13.
Cell Rep ; 41(10): 111752, 2022 12 06.
Artigo em Inglês | MEDLINE | ID: mdl-36476854

RESUMO

Temperate phages dynamically switch between lysis and lysogeny in their full life cycle. Some Bacillus-infecting phages utilize a quorum-sensing-like intercellular communication system, the "arbitrium," to mediate lysis-lysogeny decisions. However, whether additional factors participate in the arbitrium signaling pathway remains largely elusive. Here, we find that the arbitrium signal induces the expression of a functionally conserved operon downstream of the arbitrium module in SPbeta-like phages. SPbeta yopM and yopR (as well as phi3T phi3T_93 and phi3T_97) in the operon play roles in suppressing phage lytic propagation and promoting lysogeny, respectively. We further focus on phi3T_93 and demonstrate that it directly binds antitoxin MazE in the host MazF/MazE toxin-antitoxin (TA) module and facilitates the activation of MazF's toxicity, which is required for phage suppression. These findings show events regulated by the arbitrium system and shed light on how the interplay between phages and the host TA module affects phage-host co-survival.


Assuntos
Antitoxinas , Bacteriófagos
14.
Angew Chem Int Ed Engl ; : e202216898, 2022 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-36539374

RESUMO

Physical properties of materials are mainly determined by valence electron configurations, where different valence shells would induce divergent phenomena. In compounds containing Sc2+ , 3d electron occupancy is expected, the same as other transition metal atoms like Ti3+ . But this situation still awaits experimental verification in inorganic materials. Here, we selected ScS to measure the valence electron density and orbital population of Sc2+ through delicate quantitative convergent-beam electron diffraction. With the absence of 3d orbital features around Sc-atom sites and the nearly bare population of t2g orbital, the unintuitive occupation of 4s orbital in Sc2+ is concluded. It should be the first time to report such a special electron configuration in a transition metal compound, in which 4s rather than 3d orbital is preferred. Our findings reveal the distinct behavior of Sc and probable ways to modulate material properties by controlling electron orbitals.

15.
Asian J Psychiatr ; 80: 103394, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36525766

RESUMO

OBJECTIVES: We performed a network meta-analysis (NMA) with up-to-date evidence to compare different anti-inflammatory agents to improve the treatment of bipolar disorder (BD) patients. METHODS: Four databases (i.e., the Cochrane Library, Web of Science, PubMed, and Embase) were searched for randomized controlled trials (RCTs) published between 1995 and 2022 on the use of anti-inflammatory agents in the treatment of BD. A systematic review and NMA were conducted. RESULTS: Adjunctive N-acetylcysteine (NAC) was superior to placebo for the treatment of BD according to the endpoint scale score (SMD -0.65, 95% confidence interval (CI): - 0.99 to - 0.31), response rate (odds ratio (OR) 3.42, 95% CI: 1.23-9.52), remission rate (OR 4.94, 95% CI: 1.03-41.38) and surface under the cumulative ranking curve (SUCRA) value of the endpoint scale score (0.84). Adjunctive nonsteroidal anti-inflammatory drugs (NSAIDs) were more favorable than placebo based on the remission rate (OR 3.93, 95% CI: 1.15-13.43) and were significantly more acceptable than other treatments (OR 0.60, 95% CI: 0.36-0.99). Adjunctive coenzyme Q10 (CoQ10) was superior to other agents in terms of the response rate (OR 18.85, 95% CI: 2.63-135.00), with a SUCRA value for the response rate of 0.90 and that for the remission rate of 0.71. CONCLUSION: Adjunctive NAC is recommended for the treatment of BD. Adjunctive NSAIDs and CoQ10 are still seen as effective, but more high-quality clinical studies are needed to verify their efficacy. Other anti-inflammatory agents may not be recommended for clinical use at present. All anti-inflammatory agents demonstrated a good safety profile. We call for further research on the combined treatment of BD with different anti-inflammatory agents to be included in future trials.

16.
Neurosci Bull ; 2022 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-36547803
17.
J Clin Med ; 11(24)2022 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-36555876

RESUMO

Head and neck squamous cell cancers (HNSCCs) represent a diverse group of tumors emerging within different mucosal surfaces of the oral cavity, nasopharynx, oropharynx, larynx, and hypopharynx. HNSCCs share common clinical risk factors and genomic features, including smoking, alcohol, age, male sex, aneuploidy, and TP53 mutations. Viral initiating and contributing events are increasingly recognized in HNSCCs. While both Epstein-Barr Virus (EBV) and human papilloma virus (HPV) are observed, EBV is more frequently associated with nasopharyngeal cancers whereas HPV is associated with oropharyngeal cancers. HNSCCs are associated with high tumor mutational burden and loss of tumor suppressor gene function, especially in TP53 and X-linked genes. Multiple lines of evidence suggest that HNSCCs are subject to immunologic surveillance and immune-induced evolutionary pressure that correlate with negative clinical outcomes. This review will discuss genomic mechanisms related to immune-mediated pressures and propose prognostic and therapeutic implications of detectable immune escape mechanisms that drive tumorigenesis and disease progression.

18.
Front Public Health ; 10: 837911, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36339200

RESUMO

Purpose: The popularization of the internet has promoted the implementation of China's national fitness strategy and created conditions for Chinese residents to participate in sports. The internet is an essential medium for disseminating sports knowledge, and the use of the internet can change sport participation behaviors. Therefore, the internet can be used to popularize sports knowledge and promote the participation of all people in sports and thus improve the health of the entire population. This study attempts to empirically analyse how the use of the internet changes sport participation behavior. Method: Utilizing data from the 2017 China General Social Survey, a probit model, ivprobit model, and bias-corrected non-parametric percentile bootstrap test were used to analyse the impact of internet use on sport participation behavior. Results: The empirical results show that internet use significantly increased the probability of participation in sports by Chinese residents. Heterogeneity test results showed that internet use was more effective in promoting sport participation in middle-aged groups, groups of older persons, unmarried groups, and groups with a high school education or above. The mediating effect test results showed that internet use influenced residents' participation in sports by promoting social interaction, leisure and entertainment, and learning and recharging. Conclusions: The internet has changed participation in sports; specifically, the use of the internet promotes sport participation. Additionally, internet use has a more obvious impact on improving the sport participation behavior of middle-aged, older, unmarried, and middle- and higher-educated individuals. Internet social interaction, internet entertainment and internet learning are effective channels to encourage Chinese residents to participate in sports and improve their health.


Assuntos
Uso da Internet , Esportes , Humanos , Idoso , Idoso de 80 Anos ou mais , Pessoa de Meia-Idade , Exercício Físico , Comportamentos Relacionados com a Saúde , China
19.
Chin Med ; 17(1): 131, 2022 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-36434729

RESUMO

BACKGROUND: Acute lung injury (ALI) is a severe inflammatory disease, underscoring the urgent need for novel treatments. Nauclea officinalis Pierre ex Pitard (Danmu in Chinese, DM) is effective in treating inflammatory respiratory diseases. However, there is still no evidence of its protective effect against ALI. METHODS: Metabolomics was applied to identify the potential biomarkers and pathways in ALI treated with DM. Further, network pharmacology was introduced to predict the key targets of DM against ALI. Then, the potential pathways and key targets were further verified by immunohistochemistry and western blot assays. RESULTS: DM significantly improved lung histopathological characteristics and inflammatory response in LPS-induced ALI. Metabolomics analysis showed that 16 and 19 differential metabolites were identified in plasma and lung tissue, respectively, and most of these metabolites tended to recover after DM treatment. Network pharmacology analysis revealed that the PI3K/Akt pathway may be the main signaling pathway of DM against ALI. The integrated analysis of metabolomics and network pharmacology identified 10 key genes. These genes are closely related to inflammatory response and cell apoptosis of lipopolysaccharide (LPS)-induced ALI in mice. Furthermore, immunohistochemistry and western blot verified that DM could regulate inflammatory response and cell apoptosis by affecting the PI3K/Akt pathway, and expression changes in Bax and Bcl-2 were also triggered. CONCLUSION: This study first integrated metabolomics, network pharmacology and biological verification to investigate the potential mechanism of DM in treating ALI, which is related to the regulation of inflammatory response and cell apoptosis. And the integrated analysis can provide new strategies and ideas for the study of traditional Chinese medicines in the treatment of ALI.

20.
Artigo em Inglês | MEDLINE | ID: mdl-36429564

RESUMO

Quantifying the water layout factors in a campus square helps to lay out water bodies more scientifically and utilize the microclimate effect to alleviate the heat and humidity of campus squares in summer. The West Gate Square of Fujian Agriculture and Forestry University in China has been used as the primary theoretical model, and the landscape pattern index from landscape ecology has been used to quantify the scale, shape, and dispersion of water bodies. Consider the typical weather, the summer solstice, as the experiment time. The relationship between the water body layout factors and cooling effect, the humidification effect, and the wind speed is clarified from both temporal and spatial perspectives. The data were analyzed with ENVI-met and Arcgis software. Then, the optimum campus square water body layout mode was concluded. The results show that: (1) The scale, dispersion, and shape of the water body has a significant effect on the campus temperature and humidity, while the effect on wind speed is not significant. (2) From the cooling and humidifying effect, the ranking of the regulating ability of the water body layout factors is scale > shape > dispersion; the ranking of the influence range is shape > scale > dispersion. (3) When the boundary of the square is determined, the optimum water body layout mode is that the water body area accounts for 36% of the total square area. The shape of the water body is concentrated and not dispersed square. When the water body layout is determined, the optimum layout mode of the boundary is length:width = 1:2.


Assuntos
Temperatura Baixa , Microclima , Humanos , Umidade , Temperatura , Água
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...