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1.
Sci Total Environ ; 806(Pt 2): 150612, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34597579

RESUMO

The formation of haloacetonitriles (HANs) during chlorination after sulfite/ultraviolet (UV) treatment of bromate (BrO3-) in the presence of amino acids (AAs) was investigated. During sulfite/UV treatment, the primary species hydrated electrons (eaq-) and hydrogen atom radicals (H) dominated the reduction of BrO3- to bromide (Br-), whereas the sulfite anion radicals (SO3-) and H degraded AAs to produce the intermediates HN=C(CH3)-COOH, CH3-CH=NH, and CH3-C≡N via α­hydrogen abstraction and NH2-hydrogen abstraction mechanisms. During post-chlorination, Br- was converted to HBrO/BrO-, and the HN=C(CH3)-COOH, CH3-CH=NH, and CH3-C≡N groups featured higher bromine utilization factor (BUF) and chlorine utilization factor (CUF) values than AAs, enhancing the formation of dibromoacetonitrile (DBAN) and dichloroacetonitrile (DCAN). The energetic feasibility of the transformation pathway, that is, HN=C(CH3)-COOH, CH3-CH=NH, and CH3-C ≡ N formation via hydrogen abstraction by SO3- and H and their further conversion to HANs, was proved by density functional theory calculations, which showed stepwise negative Gibbs free energy changes (ΔG < 0). The effects of pH and water matrices (e.g., HCO3-, Cl-, Fe3+, and natural organic matter) were comprehensively evaluated. Although 72% of BrO3- was removed by sulfite/UV treatment in the presence of AAs, the cytotoxicity index (CTI) and genotoxicity index (GTI) during post-chlorination increased by 213% and 125%, respectively, due to the formation of 24 CX3R-type disinfection by-products (DBPs), especially brominated DBPs. Accordingly, more attention should be given to the formation of brominated DBPs during post-chlorination when using sulfite/UV processes to remove BrO3- in the presence of AAs. As a solution, using monochloramine instead of chlorine as a disinfectant after the sulfite/UV process could significantly lower the CTI and GTI values by alleviating the formation of brominated DBPs.

2.
Food Funct ; 12(19): 9211-9228, 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34606547

RESUMO

The present study aims to investigate the protective effects of N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (M 18:3) on corticosterone-induced neurotoxicity. A neurotoxic model was established by subcutaneous injection of corticosterone (40 mg per kg bw) for 21 days. Depressive behaviors (the percentage of sucrose consumption, the immobility time in the forced swimming test, and the total distance in the open field test) were observed. The levels of the brain-derived neurotrophic factor, the contents of tumor necrosis factor-α and interleukin-6, and the numbers of positive cells of doublecortin and bromodeoxyuridine in the hippocampus were measured. The density of hippocampal neurons was calculated. The morphological changes of hippocampal neurons (the density of dendritic spines, the dendritic length, and the area and volume of dendritic cell bodies) were observed. The expression levels of synaptophysin, synapsin I, and postsynaptic density protein 95 were measured. Behavioral experiments showed that M 18:3 (5 and 25 mg per kg bw) could remarkably improve the depressive behaviors. The enzyme-linked immunosorbent assay showed that M 18:3 could considerably reduce hippocampal neuroinflammation and increase hippocampal neurotrophy. Nissl staining showed that M 18:3 could remarkably improve the corticosterone-induced decrease in the hippocampal neuron density. Immunofluorescence analysis showed that M 18:3 could considerably promote hippocampal neurogenesis. Golgi staining showed that M 18:3 could remarkably improve the corticosterone-induced changes in the hippocampal dendritic structure. Western blotting showed that M 18:3 could considerably increase the expression levels of synaptic-structure-related proteins in the hippocampus. In conclusion, the protective effects of M 18:3 may be attributed to the anti-inflammatory, neurotrophic, and synaptic protection properties.

3.
Chemphyschem ; 2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34643984

RESUMO

Laser induced thermal effect is inevitable in the up-conversion particle assisted near-infrared polymerization (UCAP). In this article, the influence of thermal effect on the polymerization behavior is investigated. The effects of up-conversion particles content and NIR laser intensity on the polymerization rate and surface oxygen inhibition were systematically investigated, and the temperature evolution and complex viscosity changes in the polymerization system during the polymerization process were also monitored. In addition, polymerization experiments conducted on a controlled temperature platform were used to study the effect of NIR heating on the polymerization behavior. The results show that the near-infrared thermal effect promotes the polymerization reaction, but also causes severe oxygen inhibition which has an adverse effect on polymerization. Finally, NIR curing materials with enhanced mechanical properties than those of conventional UV curing materials were obtained.

4.
Chemosphere ; 287(Pt 1): 132049, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34474390

RESUMO

Novel pre-coagulation-sedimentation integrated with ultraviolet activated sodium percarbonate (SPC) (Fe(III)-UV/SPC) processes are promising methods for ultrafiltration (UF) pretreatment to ensure the safety of rural drinking water and mitigate UF membrane fouling. The process of surface water purification using the integrated coagulation-advanced oxidation processes (AOPs)-UF system relies on the idea that pre-coagulation can remove hydrophobic macromolecular organic compounds, thus facilitating the oxidation of hydrophilic molecules or medium-sized macromolecules to improve the utilization efficiency of free radicals in AOPs. Compared with the UV/SPC process, the removal rates of UV254 and DOC in the Fe(III)-UV/SPC process (Fe(III) = 0.1 mM, SPC = 0.5 mM) were increased from 87.39 % to 41.45 %-93.56 % and 52.51 %, respectively. Furthermore, the dosage of SPC was reduced from 0.75 mM in UV/SPC process to 0.5 mM due to effects of pre-coagulation. The free radical quenching experiment showed that a significant radical sink of reactions with organic contaminants was formed by •OH and CO3•- in the UV/SPC process, rather than a single specific radical. The destruction of the cake layer structure, reduction in contaminant concentration, and appearance of many permeable holes on the membrane surface were the main reasons for the alleviation of UF membrane fouling. Finally, the trans-membrane pressure and reversible membrane resistance decreased from 22.33 kPa to 3.68 × 1011 m-1 to 18.28 kPa and 0.93 × 1011 m-1, respectively. These results provide new insights into the behavior of membrane fouling control and offer technical references for the long-term stable operation of the UF process.

5.
Chemosphere ; 283: 131180, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34467942

RESUMO

The raw water distribution systems (RWDSs) play key roles in urban water supply systems. The changes of disinfection byproducts (DBPs) precursors of trihalomethanes (THMs), haloacetic acids (HAAs) and halogenated acetaldehydes (HALs) in the RWDS in Taihu Basin were investigated by formation potentials. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) method and 454-pyrosequencing were employed to study the variation of molecular characteristics of low molecular weight-dissolved organic matter (LMW-DOM) and microbial communities of pipeline biofilms respectively, which played crucial roles in the variation of DBPs precursors. The results showed that both DBPs precursors and the molecular characteristics of LMW-DOM in the RWDS had changed. Moreover, the LMW-DOM could be an indicator due to the good positive correlation with precursors of HAAs and HALs. Specifically, the LMW-DOM showed continuous accumulation in the RWDS. The LMW-DOM tended to possess higher m/z and more CH2 or long alkyl chains while pre-chlorination controlled this trend. The LMW-DOM in the pre-chlorinated pipe section also possessed higher saturation. Additionally, lignins served as an important part of DBPs precursors and dominated the LMW-DOM. The microbial diversity decreased in the RWDS, and the abundance and diversity of the microbial community in the pre-chlorinated section were significantly lower than those in the no-chlorinated section. Finally, most DBPs precursors had positive correlation with dominant phylum and genus in RWDS. This study reveals variation of DBPs precursors, LMW-DOM and microbial pipeline biofilms as well, and provide important data for further research on raw water safety and stability in RWDSs.


Assuntos
Desinfetantes , Microbiota , Poluentes Químicos da Água , Purificação da Água , Desinfetantes/análise , Desinfecção , Halogenação , Trialometanos/análise , Água , Poluentes Químicos da Água/análise
6.
Urol Oncol ; 2021 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-34548234

RESUMO

PURPOSE: To further determine the efficacy and safety of bipolar androgen therapy (BAT) on patients with metastatic castration-resistant prostate cancer (mCRPC) after progression on abiraterone (ABI) or enzalutamide (ENZA). MATERIALS AND METHODS: We systematically searched the Pubmed, Web of Science and ClinicalTrials.gov up to June 2021. Literature review, study selection, and data extraction were conducted by 2 reviewers. Risk of bias was assessed according to the methodology of the European Association of Urology (EAU). A systematic review and pooled analysis were performed. The primary outcomes were PSA50 after BAT and AR-targeted therapy rechallenge, objective response rate (ORR) after BAT, and AEs after BAT. The definition of PSA50 was that participants achieving a PSA decline ≥50% according to Prostate Cancer Working Group (PCWG2) criteria. The ORR determined by determined by Response Evaluation Criteria in Solid Tumors (RECIST) included patients experienced partial response (PR) or complete response (CR). RESULTS: In a total of 74 unique records, 5 studies were eligible for inclusion. Participants who underwent BAT achieved PSA50 of 0.26 (95% CI [0.20, 0.32]) and objective response rate (ORR) of 0.32 (95% CI [0.21, 0.44]). Patients completed BAT proceeded to AR-target therapy (ABI or ENZA) achieved moderate response (PSA50 0.54, 95% CI [0.30, 0.76]). Based on our multiple subgroup analysis, type of post-BAT AR-target therapy had a strong impact on PSA50 of AR-target therapy rechallenge. Most of adverse events (AEs) were low grade. CONCLUSIONS: The present study indicated that BAT could induce clinical responses in mCRPC patients after progression on ABI or ENZA, with an acceptable side effects profile. BAT could also be able to restore sensitivity to ABI and ENZA rechallenge in a subset of patients.

7.
FEBS Lett ; 2021 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482543

RESUMO

We developed an integrated platform for analysis of parameterized data from human disease models. We report a non-negative blind deconvolution (NNBD) approach to quantify calcium (Ca2+ ) handling, beating force and contractility in human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) at the single-cell level. We employed CRISPR/Cas gene editing to introduce a dilated cardiomyopathy (DCM)-causing mutation in troponin T (TnT), TnT-R141W, into wild-type control iPSCs (MUT). The NNDB-based method enabled data parametrization, fitting and analysis in wild-type controls versus isogenic MUT iPSC-CMs. Of note, Cas9-edited TnT-R141W iPSC-CMs revealed significantly reduced beating force and prolonged contractile event duration. The NNBD-based platform provides an alternative framework for improved quantitation of molecular disease phenotypes and may contribute to the development of novel diagnostic tools.

8.
Bioorg Chem ; 115: 105182, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34333426

RESUMO

With the increasing incidence of antifungal resistance, new antifungal agents having novel scaffolds hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. In this study, we reported the design, synthesis, and pharmacological evaluation of novel 1,2,3-selenadiazole analogues by scaffold hopping strategy. Preliminary results of antifungal activity demonstrated that the new class of compounds showed broad-spectrum fungistatic and fungicidal activity. Most importantly, these newly synthesized compounds can eliminate these azole-resistant fungi and inhibit the formation of C. albicans biofilm. In particular, compound S07 showed promising antifungal activity against five azole-resistant strains with MIC values ranging from 4 to 32 µg/mL. Then, further target identification and mechanistic studies indicated that representative compound S07 exert its inhibitory activity by inhibiting fungal lanosterol 14α-demethylase enzyme (CYP51). Interestingly, representative compounds showed low cytotoxicity on mammalian cell lines. In addition, the molecular docking studies elucidated the binding modes of these compounds toward CYP51. Altogether, these results suggest that compound S07 with novel skeleton is a promising CYP51 inhibitor for treatment of fungal infections.

9.
Asian J Psychiatr ; 64: 102749, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34334350

RESUMO

Altered brain gyrification in diverse cortical regions has been reported in patients with schizophrenia, which possibly reflects deviations in early neurodevelopment. The main purpose of this study was to examine the relationship between clinical symptoms and abnormal cortical gyrification in drug-naïve patients with schizophrenia in a Chinese Han population. We calculated the whole-brain cortical gyrification of 41 patients with first-episode drug-naïve schizophrenia and 30 age- and sex-matched healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the psychopathology of patients with schizophrenia. Our results showed that compared to healthy controls, patients had higher cortical gyrification in the left lateral occipital cortex, but lower cortical gyrification in the left transverse temporal cortex. Moreover, the cortical gyrification in the left entorhinal cortex and left fusiform were both positively correlated with the general psychopathology of PANSS. Our findings indicate that abnormal cortical gyrification has occurred in the early stage of schizophrenia, suggesting that abnormal cortical gyrification may play an important role in the pathogenesis and symptomatology of schizophrenia.


Assuntos
Preparações Farmacêuticas , Esquizofrenia , Encéfalo , Humanos , Imageamento por Ressonância Magnética , Esquizofrenia/diagnóstico por imagem , Lobo Temporal
10.
Front Immunol ; 12: 717832, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34421922

RESUMO

Identifying the mechanisms underlying unexplained recurrent spontaneous abortion (URSA) can help develop effective treatments. This study provides novel insights into the biological characteristics and related pathways of differentially expressed genes (DEGs) in URSA. Nineteen patients with URSA and three healthy fertile women with regular menstruation (control group) were recruited. RNA was extracted from the two groups to determine the differential expression of immunoregulatory gene sequences. Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses were used to identify the biological functions and pathways of the identified DEGs. A protein-protein interaction (PPI) network was constructed using the STRING database. Furthermore, qRT-PCR and ELISA were performed to validate the differential expression of the hub genes. We also explored the regulatory mechanism of Th1/Th2 imbalance. A total of 99 DEGs were identified, comprising 94 upregulated and five downregulated genes. Through GO analysis, nine immune cell function-related clusters were selected, and genes with significant differential expression were primarily enriched in eight immune regulatory functions related to the KEGG signalling pathway. Subsequently, five hub genes (TLR2, CXCL8, IFNG, IL2RA, and ITGAX) were identified using Cytoscape software; qRT-PCR confirmed the differential expression among the hub genes, whereas ELISA revealed a significant difference in extracellular IFN-γ and IL-8 levels. The levels of Th1 (IFN-γ) and the Th1/Th2 ratio were higher in the peripheral blood of URSA patients than in control group patients. These findings suggest that the occurrence of URSA may be associated with the abnormal expression of some specific immunoregulatory genes involved in T-cell activation and differentiation. Among the identified DEGs, IFNG may play a key role in regulating maternal immune response. Although further validation is required, our data provide an important theoretical basis for elucidating the pathogenesis of recurrent spontaneous abortion.

11.
Artigo em Inglês | MEDLINE | ID: mdl-34338347

RESUMO

Phosphatase and tensin homolog-long (PTEN-L) is a translational isoform of PTEN, which exists in both intracellular and extracellular locations. Previous studies demonstrated that PTEN-L could inhibit oncogenesis due to its lipid phosphatase activity. However, recent studies found that PTEN-L could promote the proliferation of some types of cancer cells. Moreover, as a protein phosphatase, PTEN-L can suppress mitophagy by counteracting PTEN-induced putative kinase protein 1 (PINK1)-Parkin-mediated ubiquitin phosphorylation, namely, PTEN-L is critical for exploring the mitophagy progression and the treatment of mitochondrial diseases. Accounting for the critical functions of PTEN-L, its antibody can be used for the treatment or prognosis of tumors and mitochondrial diseases. Currently, the commercial antibody of PTEN-L is not available. In our study, the recombinant PTEN-L protein was expressed in Escherichia coli BL21 and used as an antigen to immunize Japan's big-eared white rabbit for the preparation of polyclonal antibody. The PTEN-L protein can be captured by PTEN-L antibody specifically and effectively. Taken together, a PTEN_L antibody is a valuable tool for further exploring the function of PTEN-L in oncogenesis and mitochondrial diseases, and it would be a new choice for the prognosis or treatment of cancer and mitochondrial diseases.

12.
IEEE Trans Cybern ; PP2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34460409

RESUMO

3-D object detection is a fundamental task in the context of autonomous driving. In the literature, cheap monocular image-based methods show a significant performance drop compared to the expensive LiDAR and stereo-images-based algorithms. In this article, we aim to close this performance gap by bridging the representation capability between 2-D and 3-D domains. We propose a novel monocular 3-D object detection model using self-supervised learning and auxiliary learning, resorting to mimicking the representations over 3-D point clouds. Specifically, given a 2-D region proposal and the corresponding instance point cloud, we supervise the feature activation from our image-based convolution network to mimic the latent feature of a point-based neural network at the training stage. While state-of-the-art (SOTA) monocular 3-D detection algorithms typically convert images to pseudo-LiDAR with depth estimation and regress 3-D detection with LiDAR-based methods, our approach seeks the power of the 2-D neural network straightforwardly and essentially enhances the 2-D module capability with latent spatial-aware representations by contrastive learning. We empirically validate the performance improvement from the feature mimicking the KITTI and ApolloScape datasets and achieve the SOTA performance on the KITTI and ApolloScape leaderboard.

13.
Nano Lett ; 2021 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-34279960

RESUMO

Heavy Fermion (HF) states emerge in correlated quantum materials due to the intriguing interplay between localized magnetic moments and itinerant electrons but rarely appear in 3d-electron systems due to high itinerancy of d-electrons. Here, an anomalous enhancement of Kondo screening is observed at the Kondo hole of local Fe vacancies in Fe3GeTe2 which is a recently discovered 3d-HF system featuring Kondo lattice and two-dimensional itinerant ferromagnetism. An itinerant Kondo-Ising model is established to reproduce the experimental results and provides insight into the competition between Ising ferromagnetism and Kondo screening. Our work explains the microscopic origin of the d-electron HF states in Fe3GeTe2 and inspires future studies of the enriched quantum many-body effects with Kondo holes.

14.
J Hazard Mater ; 420: 126686, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34329104

RESUMO

Photocatalysis and peroxymonosulfate (PMS) based advanced oxidation processes (AOP) are emerging technology for the degradation of refractory organic pollutant in the field of water treatment. Here we report a novel CoO@TiO2/MXene (CTM) hybrid through a facile sonication-hydrothermal method for efficient degradation of phenol via an integrated PMS activation-photocatalysis process. Benefiting from the proper position and superior suitability of the band structure, a dual interfacial charge transport channel was constructed, boosting the separation of photo-generated charge carriers and generating sufficient potential difference for redox reaction. Accordingly, the CTM hybrid not only possessed the outstanding photocatalytic activity but also dramatically accelerated PMS activation to generate considerable reactive radicals. As a result, over 96% phenol degradation was achieved in the 10% CTM/PMS/Vis system within 15 min. The radical quenching test and EPR analysis reveal that SO4•-, O2•- and 1O2 were predominant reactive species involved in the catalytic process. Moreover, the damaged chemical structure of CoO during PMS activation could be healed by the photo-actuated Co(II) regeneration to allow for continuous and stable catalytic process. This study offers a promising perspective for the rational design of competent and stable hybrid heterojunction catalyst to construct PMS activation-photocatalysis processes for the efficient degradation of organic contaminants.

15.
Urol Oncol ; 2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34330654

RESUMO

BACKGROUND: Emerging evidence indicates that patients with metastatic castration-resistant prostate cancer could respond to steroid switch from prednisone (P) to dexamethasone (D) following progression on abiraterone acetate plus prednisone (AA+P). OBJECTIVES: Conducting a systematic review to evaluate the efficacy, safety, and prognostic factors of steroid switch. MATERIALS AND METHODS: We systematically searched Pubmed, Web of Science, and American Society of Clinical Oncology annual meeting abstracts published up to October 2020. Literature review, study selection, and data extraction were conducted by two reviewers. Risk of bias (RoB) and quality of evidence were assessed. A systematic review and pooled analysis were performed. RESULTS: Nine studies were eligible for inclusion. All of the included patients were progression on AA+P. Pooled rates of PSA50 and PSA30 on abiraterone acetate plus dexamethasone (AA+D) were 0.24 (95%CI [0.18,0.30]) and 0.42 (95%CI [0.36,0.48]), respectively. Subgroup analysis indicated more favorable PSA50 and PSA30 rates on AA+D when switching from P to D only based on PSA progression. Median time to PSA progression on AA+D ranged from 2.73 to 11.38 months. Definitions of progression free survival were variable. Reported median progression free survival on AA+D ranged from 2.52 to 11.8 months. Median overall survival on AA+D varied from 4.11 to 20.9 months. All patients tolerated well on AA+D, and no grade 3 to 4 adverse events were reported. Baseline characteristics of patients, previous treatment and its response, and genetic alterations might all play roles in the response in the response toward the AA+D regimen. CONCLUSIONS: The present systematic review suggested that steroid switch from P to D might be an effective and safe treatment strategy in a subset of patients with metastatic castration-resistant prostate cancer after PSA progression on AA+P.

16.
Artigo em Inglês | MEDLINE | ID: mdl-34281088

RESUMO

Agricultural water use accounts for the largest proportion of water withdrawal, so improving agricultural water use efficiency is an important way to alleviate water shortage. However, the expected water saving by the improved agricultural water use efficiency may be offset by the rebound effect, which means the goal of water saving by improving agricultural water use efficiency is not achieved. Based on the definition of the rebound effect of agricultural water use, this paper first uses a fixed model to measure the causal effect of agricultural water use efficiency on agricultural water use to analyze the agricultural water rebound effect, then analyses the heterogeneity and mechanism of the effect of agricultural water use efficiency on agricultural water use with the panel data from 30 provinces or cities in China from 2000 to 2017. The results show that, firstly, the agricultural water use efficiency has a significant negative effect on agricultural water use, but the average agricultural water rebound effect is 88.81%. Secondly, the effect of agricultural water use efficiency on agricultural water use is heterogeneous, in which the improvement of agricultural water use efficiency in humid or major grain-producing areas will have a lower agricultural water rebound effect. Finally, agricultural water use efficiency can affect agricultural water use through planting area and planting structure. An increase in agricultural water use efficiency will expand the planting area to increase water use. However, this will change the planting structure to decrease water use. The implication for agricultural water management is that the irrigation agricultural scale has to be controlled under the condition of available water resource, while improving agricultural water use efficiency.


Assuntos
Agricultura , Água , Irrigação Agrícola , China , Grão Comestível , Recursos Hídricos
18.
Clin Appl Thromb Hemost ; 27: 10760296211031291, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34325549

RESUMO

Venous thromboembolism (VTE) is a common and potentially fatal complication in cancer patients. Although several genetic risk factors related to thrombophilia have been identified, their contributions for the occurrence of VTE in cancer patients have conflicting results. The aim of this study was to evaluated the gene polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and plasminogen activator inhibitor-1 (PAI-1) 4G/5G in lung cancer patients, with and without VTE, and the combined effect on the risk of VTE. 92 lung cancer patients diagnosed with VTE (VTE group) and 122 lung cancer patients without VTE (non-VTE group) were enrolled in the study. The gene polymorphisms were analyzed by the method of polymerase chain reaction-restriction fragment length polymorphism. Gene mutation of factor V Leiden was not detected both in non-VTE group and VTE group. The frequency of MTHFR C677T homozygous mutation in VTE group was 25.00%, higher than that in the non-VTE group without statistical difference. It was found that the PAI-1 4G4G genotype is associated with a higher risk of VTE (OR: 2.62, 95%CI: 1.19-5.75). Interestingly, the interaction between MTHFR C677T and PAI-1 4G/5G polymorphisms showed that the coexistence of the 2 homozygous mutation could further increase the risk of VTE. In conclusion, PAI-1 4G/5G polymorphism may be an increased risk factor for VTE among lung cancer patients in Chinese population. The homozygous MTHFR C677T mutation may be not a risk factor for VTE but increases the risk, accompanied with PAI-1 4G5G genotype.

19.
Chem Commun (Camb) ; 57(61): 7537-7540, 2021 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-34236352

RESUMO

A novel cluster-based MOF with uncommon multicentered ZnI-ZnI bonds {[K1.2Na2.8ZnI8(HL)12]·4H2O}n (HL = tetrazole monoanion) (1) was synthesized, which showed higher stability than the reported ZnI-ZnI bonded compounds. Moreover, 1 can effectively and circularly catalyze the cyclization of CO2 and aziridines or epoxides with five substituent groups. Importantly, this is the first time that the catalytic properties of MOFs with multicentered metal-metal bonded clusters as the catalyst have been studied.

20.
Nanoscale ; 13(24): 10898-10905, 2021 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-34126628

RESUMO

Chiral metasurfaces which can achieve different optical responses for left-handed and right-handed circularly polarized (CP) light have been proposed. Most of the research studies on chiral metasurfaces focus on improving circular dichroism (CD) and realizing dynamic manipulation of the chiro-optical response. However, there have only been a few reports on the multi-band chiro-optical response. Here, we propose an all-silicon chiral meta-atom which can realize spin-selective transmission in a dual band. In addition, a terahertz metasurface with spin-selective transmission through phase arrangement is designed by using chiral meta-atoms satisfying a gradient geometric phase. Under left-hand circularly polarized (LCP) incidence, the metasurface generates a focused right-hand circularly polarized (RCP) beam which is focused at a distance of 4.8 mm from the exit surface of the metasurface. Our work broadens the concept of metasurface design and may attract more researchers' attention on the applications of chiral metasurfaces.

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