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1.
Materials (Basel) ; 16(1)2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36614745

RESUMO

In present paper, a novel flowable tritium breeder is prepared by mixing the Li2TiO3 micro-powders and liquid GaInSn alloy, where GaInSn alloy is used to simulate the fluid behaviors of lithium-based liquid tritium breeder, forming a type of composite characterized by liquid-solid dual phase. In detail, the effects of the volume fraction of ceramic micro-powders on viscosity and conductivity of the composite in magnetic field are the focus. The XRD results prove that the obtained Li2TiO3 micro-powders contained Li2TiO3 phase without impurities. The results shows that once the magnetic field intensity exceeds the critical value, the viscosity of liquid GaInSn metal becomes significantly greater than that of liquid-solid dual-phase composites. Furthermore, the addition of Li2TiO3 micro-powders could effectively reduce the magneto hydro dynamic (MHD) fluid effect, and the dual-phase composites exhibit comparatively lower flow resistance under the strong magnetic field. Moreover, the conductivity of the tritium breeder composites decreases rapidly with the addition of Li2TiO3 micro-powders. The MHD pressure-drop-increasing rate decreases with the increase of viscosity, which indicates that the addition of Li2TiO3 micro-powders effectively reduces the MHD effect. The conductivity of the composites increased slightly and then remained stable after static placing for several tens of minutes. The present investigation provides a novel insight into the fabrication strategy of tritium breeder materials with low MHD effect.

2.
Cell Death Discov ; 9(1): 11, 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36653336

RESUMO

The perinatal period occurring immediately before and after birth is critical for cardiomyocytes because they must change rapidly to accommodate the switch from fetal to neonatal circulation after birth. This transition is a well-orchestrated process, and any perturbation leads to unhealthy cardiomyocytes and heart disease. Despite its importance, little is known about how this transition is regulated and controlled. Here, by mapping the genome-wide chromatin accessibility, transcription-centered long-range chromatin interactions and gene expression in cardiomyocytes undergoing perinatal transition, we discovered two key transcription factors, MEF2 and AP1, that are crucial for driving the phenotypic changes within the perinatal window. Thousands of dynamic regulatory elements were found in perinatal cardiomyocytes and we show these elements mediated the transcriptional reprogramming through an elegant chromatin high-order architecture. We recompiled transcriptional program of induced stem cell-derived cardiomyocytes according to our discovered network, and they showed adult cardiomyocyte-like electrophysiological expression. Our work provides a comprehensive regulatory resource of cardiomyocytes perinatal reprogramming, and aids the gap-filling of cardiac translational research.

3.
BMC Psychiatry ; 23(1): 5, 2023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-36597052

RESUMO

BACKGROUND: Cognitive reserve is a modifiable factor that could prevent cognitive decline in patients with cancer. The Cognitive Reserve Assessment Scale in Health (CRASH) is an instrument used to assess cognitive reserve. This study aims to develop and examine the psychometric properties of the Chinese version of the CRASH for patients with cancer. METHODS: A cross-sectional survey was conducted with 167 cancer patients from four wards of two hospitals in China. Thirty-one patients were re-assessed to examine the test-retest reliability. Four translators and three reviewers developed the Chinese version of the scale. We assessed its structural validity, concurrent validity, internal consistency, test-retest reliability, measurement error, and floor/ceiling effects. RESULTS: Confirmatory factor analysis showed a good model fit with the four-factor structure of the original CRASH. The CRASH scores were statistically significantly associated with neuropsychological test scores, indicating sufficient concurrent validity. The internal consistency was acceptable, except for leisure activities, with standardized Cronbach's alphas (0.64-0.94) and standardized Omega (0.66-0.95). There was excellent test-retest reliability, with a high intraclass correlation coefficient (0.914-0.993) of total scores and scores for each domain. The measurement error was acceptable, and no floor or ceiling effects were observed. CONCLUSIONS: The Chinese version of the CRASH is a valid and reliable instrument to assess cognitive reserve in patients with cancer. Moreover, cognitive reserve measured by the CRASH was associated with low cognitive performance in cancer patients.


Assuntos
Reserva Cognitiva , Neoplasias , Humanos , Psicometria , Reprodutibilidade dos Testes , Estudos Transversais , Neoplasias/complicações , China , Inquéritos e Questionários
4.
Phys Chem Chem Phys ; 25(3): 2274-2281, 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36597784

RESUMO

Strong structural asymmetry is actively explored in two-dimensional (2D) materials, because it can give rise to many interesting physical properties. Motivated by the recent synthesis of monolayer Si2Te2, we explored a family of 2D materials, named Janus Si dichalcogenides (JSD), which parallel the Janus transition metal dichalcogenides and exhibit even stronger inversion asymmetry. Using first-principles calculations, we show that their strong structural asymmetry leads to a pronounced intrinsic polar field, sizable spin splitting, and large piezoelectric response. The spin splitting involves an out-of-plane spin component, which is beyond the linear Rashba model. The piezoelectric tensor has a large value in both in-plane d11 coefficient and out-of-plane d31 coefficient, making monolayer JSDs distinct among existing 2D piezoelectric materials. In addition, we find interesting strain-induced phase transitions in these materials. Particularly, there are multiple valleys that compete for the conduction band minimum, which will lead to notable changes in the optical and transport properties under strain. Our work reveals a new family of Si based 2D materials, which could find promising applications in spintronic and piezoelectric devices.

5.
Life (Basel) ; 13(1)2023 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-36676183

RESUMO

Aflatoxin B1 (AFB1) is a common mycotoxin contaminant in cereals that causes severe economic losses and serious risks to the health of humans and animals. In this paper, we investigated the characteristics of AFB1 degradation by black soldier fly larvae (BSFL) combined with commensal intestinal microorganisms. Germ-free BSFL and non-sterile BSFL were reared on peanut meal spiked with AFB1 for 10 days. The result showed that germ-free BSFL and non-sterile BSFL could achieve 31.71% and 88.72% AFB1 degradation, respectively, which indicated the important role of larvae gut microbiota in AFB1 degradation. Furthermore, twenty-five AFB1-degrading bacteria were isolated from BSFL gut, and S. acidaminiphila A2 achieved the highest AFB1 degradation, by 94%. When S. acidaminiphila A2 was re-inoculated to BSFL, the detrimental effect of AFB1 on the growth performance of BSFL was alleviated, and complete AFB1 degradation in peanut meal was obtained. In conclusion, the present study may provide a strategy to degrade AFB1 in feedstuff through bioconversion with BSFL in combination with gut-originated AFB1-degrading bacteria, while providing a sustainable insect protein and fat source to animals.

6.
Anal Chem ; 95(2): 1627-1634, 2023 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-36574294

RESUMO

A novel dual-mode microfluidic analytical device integrating self-powered photoelectrochemical (PEC) sensing with electrochromic visualization analysis was developed for ultrasensitive ofloxacin (OFL) detection. First, an advanced dual direct Z-scheme BiVO4@Ni-ZnIn2S4/Bi2S3 (BVZIS) heterojunction was designed as a photoanode matrix to steadily provide electrons. The dual Z-scheme structure formed in photoactive BVZIS composites greatly accelerated the migration of electrons. In addition, the doping of Ni in ZnIn2S4 markedly enhanced the optical absorption and promoted the separation of the photocarrier. Second, electrochromic material polyaniline-modified Au (Au/PANI) was first electrodeposited on the photocathode for immobilizing aptamers and realizing visualized readout. On the one hand, Au/PANI with excellent conductivity could receive electrons from the photoanode without external energy supply. On the other hand, PANI would be rapidly reduced by the received electrons and change its color from blue to green obviously. With the increase in OFL, the increased steric hindrance resulted in the significant decline in the PEC signal and RGBgreen value. Third, wide linear ranges of PEC (0.05 pg/mL to 150 ng/mL) and electrochromic technique (0.1 pg/mL to 100 ng/mL) as well as low detection limits of PEC (18 fg/mL) and electrochromic (30 fg/mL) sensors could achieve the ultrasensitive detection of OFL in milk and river water.


Assuntos
Aptâmeros de Nucleotídeos , Técnicas Biossensoriais , Técnicas Biossensoriais/métodos , Elétrons , Microfluídica , Ouro/química , Técnicas Eletroquímicas/métodos , Aptâmeros de Nucleotídeos/química , Limite de Detecção
7.
Plant Physiol Biochem ; 194: 374-382, 2022 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-36470152

RESUMO

Antibiotic pollution has become a global environmental pollution problem. Chlorophyll fluorescence is one of the most important indicators reflecting the degree to which plants are influenced by the environment. Ofloxacin (OFL) is a highly toxic antibiotic pollutant, and there are few reports on the effects of changes in OFL levels on tomato chlorophyll fluorescence parameters. In this study, we investigated the responses of tomato growth, photosynthetic activity and chlorophyll fluorescence kinetics to exogenous OFL exposure (as the concentrations of 0, 2.5, 5, 10 and 20 mg L-1). The results showed that lower concentrations of OFL (2.5 mg L-1) had little impact on tomato growth, while plant growth was inhibited with the OFL concentration increasing. At higher OFL concentrations (5, 10 and 20 mg L-1), chloroplasts ruptured, and chlorophyll became degraded, resulting in leaf etiolation. Furthermore, the photosynthetic and photochemical efficiency and electron transfer rate were significantly inhibited by OFL. Moreover, damage to the oxygen-evolving complex on the donor side of PSⅡ prevented electron transfer from QA to QB and led to photoinhibition. In conclusion, higher OFL concentration reduced photosynthesis by destroying the photosynthetic mechanism in tomato, resulting in tomato leaf etiolation and plant growth inhibition.

8.
Front Public Health ; 10: 1025670, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36466532

RESUMO

Background: To examine the association between daily physical activity (PA) and major adverse cardiovascular events (MACEs) in northwest China. Methods: The data in this analysis were part of the baseline survey of the Regional Ethnic Cohort Study in Northwest China from June 2018 to May 2019 in Shaanxi Province. This study used standardized self-reported total physical activity (continuous and categorical variables) and self-reported outcomes of MACEs. All analyses were conducted using the logistic regression model and stratified by age, sex, body mass index (BMI), and region. The dose-response relationships were assessed with a restricted cubic spline. Results: The average level of total PA was 17.60 MET hours per day (MET-h/d). Every increase of four MET-h/d of total PA was associated with a lower risk of MACEs [adjusted OR = 0.95 (95% CI, 0.93~0.98)]. Compared with participants in the bottom quartile of total PA, a lower risk of MACEs was observed in the top quartile group [≥23.3 MET-h/d, 0.68 (0.55~0.83)]. Stratified analyses showed similar results in males, females, participants over 45 years old, participants in the rural region, and normal weight range participants (BMI < 24 kg/m2). Total participants also observed a dose-response relationship after adjusting for socioeconomic and lifestyle factors. Conclusions: A higher level of PA was associated with a lower MACE risk. Future research should examine the longitudinal association of prospectively measured PA and the risk of MACEs.


Assuntos
Doenças Cardiovasculares , Exercício Físico , Feminino , Masculino , Humanos , Pessoa de Meia-Idade , Estudos Transversais , Estudos de Coortes , China/epidemiologia , Doenças Cardiovasculares/epidemiologia
9.
Opt Express ; 30(26): 46626-46648, 2022 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-36558611

RESUMO

In this paper, we put forward a data-driven fiber model based on the deep neural network with multi-head attention mechanism. This model, which predicts signal evolution through fiber transmission in optical fiber telecommunications, can have advantages in computation time without losing much accuracy compared with conventional split-step fourier method (SSFM). In contrast with other neural network based models, this model obtains a relatively good balance between prediction accuracy and distance generalization especially in cases where higher bit rate and more complicated modulation formats are adopted. By numerically demonstration, this model can have ability of predicting up to 16-QAM 160Gbps signals with any transmission distances ranging from 0 to 100 km under both circumstances of the signals without or with the noise.

10.
Opt Express ; 30(26): 46822-46837, 2022 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-36558624

RESUMO

Coded aperture snapshot spectral imaging (CASSI) can acquire rich spatial and spectral information at ultra-high speed, which shows extensive application prospects. CASSI innovatively employed the idea of compressive sensing to capture the spatial-spectral data cube using a monochromatic detector and used reconstruction algorithms to recover the desired spatial-spectral information. Based on the optical design, CASSI currently has two different implementations: single-disperser (SD) CASSI and dual-disperser (DD) CASSI. However, SD-CASSI has poor spatial resolution naturally while DD-CASSI increases size and cost because of the extra prism. In this work, we propose a deep learning-enabled reflective coded aperture snapshot spectral imaging (R-CASSI) system, which uses a mask and a beam splitter to receive the reflected light by utilizing the reflection of the mask. The optical path design of R-CASSI makes the optical system compact, using only one prism as two dispersers. Furthermore, an encoder-decoder structure with 3D convolution kernels is built for the reconstruction, dubbed U-net-3D. The designed U-net-3D network achieves both spatial and spectral consistency, leading to state-of-the-art reconstruction results. The real data is released and can serve as a benchmark dataset to test new reconstruction algorithms.

11.
Front Plant Sci ; 13: 1046178, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36507397

RESUMO

Introduction: Millet-based dryland agriculture is the traditional mode of agricultural cultivation in northern China and has been of great significance to the emergence and development of Chinese civilization. However, although they are both millet-based agricultural production methods, with various subtypes in different regions of northern China. In the Songhua River Region in northeast China, the ecological environment and abundant natural resources led to the slow development of agriculture, and it was only after the Liaojin Dynasties that a mature farming industry was formed. Material and Method: We used the plant flotation instrument to flotation the soil samples unearthed in the Luotong Mountain City, a Liaojin period site in Songhua River Region, northeast China, and collected the charred plant seeds. Then observing them with the electron microscope, we identified and counted the plant seeds in this site. Result: It was found that this region is still a millet-based crop utilization structure, and a total of 11 types of charred agricultural crop seeds were excavated from flotation at the Luotong Mountain City site. And the barnyard millet crops occupy a prominent advantage, with ubiquity of more than 91%. Discussion: The ancestors of this region were still engaged in a millet-based agricultural strategy during this period, with a certain lag compared to the Central Plains'agricultural strategy where Triticeae crops had become dominant. In addition, the crop structure with the millet-based agriculture of the region is also somewhat different from that of the Central Plains. Through comparative studies of surrounding sites and reference to historical documents, it was found that this difference in crop structure is a phenomenon unique to the Songhua River Region and is related to the dietary habits of the local settled Jurchen nomads, who ate barnyard millet meal.

12.
Biochim Biophys Acta Rev Cancer ; 1878(1): 188849, 2022 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-36502928

RESUMO

The recent decade has witnessed a vigorous prosper of antibody-drug conjugates (ADCs) in solid tumors including breast cancer. Integrating the specificity of monoclonal antibodies and potency of cytotoxic drugs, ADCs are capable of delivering cytotoxic agents directly to tumor cells and surrounding accomplices with heterogeneous antigen expression by exerting the distinctive bystander effect. Up till now, three ADCs (T-DM1, T-DXd and SG) have attained the official approval and stepped into clinical practices in breast cancer, with numerous promising products in the pipeline. As an unprecedented breast cancer subgroup identified following solidified drug benefit, the cognitive and therapeutic paradigm of HER2-low population which was previously thought lacking definite targets and efficacious regimens has been thoroughly rewritten by ADCs, and several encouraging achievements are expected in ongoing trials. Herein, we discuss the contrived knowledge, latest advancements and future perspectives of ADCs in HER2-overexpressing and HER2-low breast cancer.

13.
RSC Adv ; 12(54): 34904-34909, 2022 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-36540266

RESUMO

Fabricating high-capacity electrode materials toward supercapacitors has attracted increasing attention. Here we report a three-dimensional CNTs/NiCo2S4 nanocomposite material synthesized successfully by a facile one-step hydrothermal technique. As expected, a CNTs/NiCo2S4 electrode shows remarkable capacitive properties with a high specific capacitance of 890 C g-1 at 1 A g-1. It also demonstrates excellent cycle stability with an 83.5% capacitance retention rate after 5000 cycles at 10 A g-1. Importantly, when assembled into a asymmetric supercapacitor, it exhibits a high energy density (43.3 W h kg-1) and power density (800 W kg-1). The exceptional electrochemical capacity is attributed to the structural features, refined grains, and enhanced conductivity. The above results indicate that CNTs/NiCo2S4 composite electrode materials have great potential application in energy-storage devices.

14.
Phys Chem Chem Phys ; 25(1): 604-611, 2022 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-36484335

RESUMO

Graphene plasmons, possessing a lot of unique optical properties, have been employed to enable a variety of applications in the THz frequency range. Here, we demonstrate bound states in the continuum (BICs), electromagnetically induced transparency (EIT)-like effects, high-performance broadband optical absorption (OA), and narrow-band OA in a square lattice of graphene non-concentric rings (GNCRs). We show that due to inversion symmetry breaking, the symmetry-protected BICs will evolve into quasi-BICs as the eccentricity of GNCRs becomes nonzero, manifested itself as a new resonance dip appearing in the transmission spectrum. The observation can be well described by a coupled-oscillator model, namely, the coupling between a dipole state and a quadrupole state. Besides, as the eccentricity becomes very large, the structure can also support EIT-like effects, in which a transparency window will occur at the frequency of the original transmission dip caused by the dipole state, and the transmission spectrum turns into a typical W-shape. Based on the idea of BICs, we propose a broadband terahertz (THz) perfect OA by using the typical sandwiched structure, namely, with the configuration of the GNCR layer-spacer layer-metal layer. Full wave simulations are performed, which show that the OA of over 90% absorptance can be achieved at frequencies from 0.67 THz to 1.66 THz, and over 99% absorptance can be achieved at frequencies from 1.24 THz to 1.49 THz. In the absorption band, three peaks come from three graphene plasmonic modes, which are two dipole resonances and a quadrupole resonance induced by symmetry breaking. Moreover, the perfect OA performance can be well maintained for oblique incidences of transverse electric polarization, with an incidence angle of up to 30°. Finally, we show that the broadband perfect OA can be switched to narrowband perfect OA, and its operating frequency can be continuously tuned by changing the Fermi level. Our results will promote the development of graphene-based applications in THz and infrared regimes.

15.
Artigo em Inglês | MEDLINE | ID: mdl-36577637

RESUMO

BACKGROUND AND AIMS: Reducing consumption of sugar-sweetened beverages (SSBs) is a global public health priority because of their limited nutritional value and associations with increased risk of obesity and metabolic diseases. Gut microbiota-related metabolites emerged as quintessential effectors that may mediate impacts of dietary exposures on the modulation of host commensal microbiome and physiological status. METHODS AND RESULTS: This study assessed the associations among SSBs, circulating microbial metabolites, and gut microbiota-host co-metabolites, as well as metabolic health outcomes in young Chinese adults (n = 86), from the Carbohydrate Alternatives and Metabolic Phenotypes study in Shaanxi Province. Five principal component analysis-derived beverage drinking patterns were determined on self-reported SSB intakes, which were to a varying degree associated with 143 plasma levels of gut microbiota-related metabolites profiled by untargeted metabolomics. Moreover, carbonated beverages, fruit juice, energy drinks, and bubble tea exhibited positive associations with obesity-related markers and blood lipids, which were further validated in an independent cohort of 16,851 participants from the Regional Ethnic Cohort Study in Northwest China in Shaanxi Province. In contrast, presweetened coffee was negatively associated with the obesity-related traits. A total of 79 metabolites were associated with both SSBs and metabolic markers, particularly obesity markers. Pathway enrichment analysis identified the branched-chain amino acid catabolism and aminoacyl-tRNA biosynthesis as linking SSB intake with metabolic health outcomes. CONCLUSION: Our findings demonstrate the associations between habitual intakes of SSBs and several metabolic markers relevant to noncommunicable diseases, and highlight the critical involvement of gut microbiota-related metabolites in mediating such associations.

16.
Chin Med J (Engl) ; 135(20): 2436-2445, 2022 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-36583862

RESUMO

BACKGROUND: Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer (TNBC). One of the immunosuppressive pathways involves programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1), but many patients derived little benefit from PD-1/PD-L1 checkpoint blockades treatment. Prior research has shown that MYC, a master transcription amplifier highly expressed in TNBC cells, can regulate the tumor immune microenvironment and constrain the efficacy of immunotherapy. This study aims to investigate the regulatory relationship between MYC and PD-L1, and whether a cyclin-dependent kinase (CDK) inhibitor that inhibits MYC expression in combination with anti-PD-L1 antibodies can enhance the response to immunotherapy. METHODS: Public databases and TNBC tissue microarrays were used to study the correlation between MYC and PD-L1. The expression of MYC and PD-L1 in TNBCs was examined by quantitative real-time polymerase chain reaction and Western blotting. A patient-derived tumor xenograft (PDTX) model was used to evaluate the influence of a CDK7 inhibitor THZ1 on PD-L1 expression. Cell proliferation and migration were detected by 5-ethynyl-2'-deoxyuridine (EdU) cell proliferation and cell migration assays. Tumor xenograft models were established for in vivo verification. RESULTS: A high MYC expression level was associated with a poor prognosis and could alter the proportion of tumor-infiltrating immune cells (TIICs). The positive correlation between MYC and PD-L1 was confirmed by immunostaining samples from 165 TNBC patients. Suppression of MYC in TNBC caused a reduction in the levels of both PD-L1 messenger RNA and protein. In addition, antitumor immune response was enhanced in the TNBC cancer xenograft mouse model with suppression of MYC by CDK7 inhibitor THZ1. CONCLUSIONS: The combined therapy of CDK7 inhibitor THZ1 and anti-PD-L1 antibody appeared to have a synergistic effect, which might offer new insight for enhancing immunotherapy in TNBC.


Assuntos
Neoplasias de Mama Triplo Negativas , Humanos , Animais , Camundongos , Neoplasias de Mama Triplo Negativas/tratamento farmacológico , Neoplasias de Mama Triplo Negativas/genética , Receptor de Morte Celular Programada 1 , Ligantes , Imunoterapia , Antígeno B7-H1/genética , Apoptose , Microambiente Tumoral
17.
Nutrients ; 14(24)2022 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-36558402

RESUMO

Staple food preference vary in populations, but evidence of its associations with obesity phenotypes are limited. Using baseline data (n = 105,840) of the Regional Ethnic Cohort Study in Northwest China, staple food preference was defined according to the intake frequency of rice and wheat. Overall and specifically abdominal fat accumulation were determined by excessive body fat percentage and waist circumference. Logistic regression and equal frequency substitution methods were used to evaluate the associations. We observed rice preference (consuming rice more frequently than wheat; 7.84% for men and 8.28% for women) was associated with a lower risk of excessive body fat (OR, 0.743; 95%CI, 0.669-0.826) and central obesity (OR, 0.886; 95%CI, 0.807-0.971) in men; and with lower risk of central obesity (OR, 0.898; 95%CI, 0.836-0.964) in women, compared with their wheat preference counterparties. Furthermore, similar but stronger inverse associations were observed in participants with normal body mass index. Wheat-to-rice (5 times/week) reallocations were associated with a 36.5% lower risk of normal-weight obesity in men and a 20.5% lower risk of normal-weight central obesity in women. Our data suggest that, compared with wheat, rice preference could be associated with lower odds ratios of certain obesity phenotypes in the Northwest Chinese population.


Assuntos
Preferências Alimentares , Obesidade Abdominal , Humanos , Obesidade Abdominal/epidemiologia , Estudos de Coortes , Obesidade/epidemiologia , Gordura Abdominal , Circunferência da Cintura , China/epidemiologia , Índice de Massa Corporal , Fatores de Risco
18.
Medicine (Baltimore) ; 101(50): e32246, 2022 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-36550888

RESUMO

BACKGROUND: This meta-analysis aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on blood pressure in patients with essential hypertension to explore more suitable training. METHODS: PubMed, EBSCO, Cochrane Library, Web of Science, CNKI, and VIP databases were searched for randomized controlled trials published between January 2002 and November 2022. Weighted mean differences (WMDs) with 95% confidence intervals (CIs) were selected as the effect scale indices for the evaluation of the differences in post-intervention systolic blood pressure (SBP), and diastolic blood pressure (DBP), heart rate, maximum oxygen uptake (VO2max), and flow-mediated vasodilation. All these were compared using Review Manager 5.3 and Stata 14.0. RESULTS: A total of 13 randomized controlled trials and 442 patients were included. The meta-analyses revealed no statistically significant differences between HIIT and MICT in improving SBP and DBP in patients with hypertension. Subgroup analyses revealed that HIIT was better than MICT in reducing SBP during daytime monitoring (WMD = -4.14, 95%CI: [-6.98, -1.30], P < .001). In addition, HIIT increased flow-mediated vasodilation more than MICT in hypertensive patients (WMD = 2.75, 95%CI: [0.43, 5.07], P = .02). CONCLUSION: HIIT and MICT have similar effects on the overall resting SBP and DBP in patients with hypertension and prehypertension. However, HIIT is better than MICT at reducing SBP during daytime monitoring. In addition, HIIT can improve vasodilation.


Assuntos
Treinamento Intervalado de Alta Intensidade , Hipertensão , Hipotensão , Humanos , Pressão Sanguínea/fisiologia , Consumo de Oxigênio/fisiologia , Oxigênio , Hipertensão/terapia , Ensaios Clínicos Controlados Aleatórios como Assunto
19.
Front Cell Infect Microbiol ; 12: 986350, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36439228

RESUMO

Dendritic cells (DCs) are professional antigen-presenting cells that play an important role in both innate and acquired immune responses against pathogens. However, the role of DCs in coronavirus disease 2019 (COVID-19) is unclear. Virus-like particles (VLPs) that structurally mimic the original virus are one of the candidates COVID-19 vaccines. In the present study, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) VLPs were used as an alternative to live virus to evaluate the interaction of the virus with DCs. The results revealed that SARS-CoV-2 VLPs induced DC maturation by augmenting cell surface molecule expression (CD80, CD86, and major histocompatibility complex class II (MHC-II)) and inflammatory cytokine production (tumor necrosis factor-α, interleukin (IL)-1ß, IL-6, and IL-12p70) in DCs via the mitogen-activated protein kinase and nuclear factor-κB signaling pathways. In addition, mature DCs induced by SARS-CoV-2 VLPs promoted T cell proliferation, which was dependent on VLPs concentration. Our results suggest that SARS-CoV-2 VLPs regulate the immune response by interacting with DCs. These findings will improve the understanding of SARS-CoV-2 pathogenesis and SARS-CoV-2 vaccine development.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , Linfócitos T , Vacinas contra COVID-19 , Células Dendríticas
20.
Light Sci Appl ; 11(1): 333, 2022 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-36433949

RESUMO

Ising machines based on analog systems have the potential to accelerate the solution of ubiquitous combinatorial optimization problems. Although some artificial spins to support large-scale Ising machines have been reported, e.g., superconducting qubits in quantum annealers and short optical pulses in coherent Ising machines, the spin stability is fragile due to the ultra-low equivalent temperature or optical phase sensitivity. In this paper, we propose to use short microwave pulses generated from an optoelectronic parametric oscillator as the spins to implement a large-scale Ising machine with high stability. The proposed machine supports 25,600 spins and can operate continuously and stably for hours. Moreover, the proposed Ising machine is highly compatible with high-speed electronic devices for programmability, paving a low-cost, accurate, and easy-to-implement way toward solving real-world optimization problems.

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