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1.
Sci Total Environ ; 698: 134320, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31518779

RESUMO

Soil acidification is a major environmental issue associated with intensive agricultural land use. Rapid urbanization has inevitably caused great changes in agricultural land use around urban areas. However, the effects of agricultural land-use change and soil parent material on the pH dynamics of the whole soil profile remain poorly understood. Based on a paired soil resampling campaign in the 1980s and 2010s, this study evaluated the effects of agricultural land-use change and parent materials on the pH dynamics of the soil profile across the Chengdu Plain of China. The results showed that soil pH significantly decreased by 1.20, 0.72, 0.66 and 0.68 units at the 0-20, 20-40, 40-60 and 60-100 cm soil depths, respectively. Conversions of traditional rice-wheat/rapeseed rotations to rice-vegetable rotations and afforested land significantly increased the magnitude of pH decline at the 0-60 cm soil depth. Soils formed from Q4 grey-brown alluvium and Q4 grey alluvium, which had a lower soil bulk density (BD) and higher sand content, showed a much higher magnitude of pH decline than soils formed from Q3 (Quaternary Pleistocene) old alluvium, and significant acidification of deep soils only occurred in soils formed from Q4 (Quaternary Holocene) grey-brown alluvium and Q4 grey alluvium. These results suggested that agricultural land-use change aggravated acidification in the soil profile and the soil acidification degrees were parent material-dependent; in particular, significant acidification of deep soils was more inclined to occur in soils with lower soil BD and higher sand content due to their effects on the downward movement of acids and the penetration resistance of plant roots. More attention should be given to minimizing or preventing acidification of both topsoil and deep soils aggravated by agricultural land-use change across urban agricultural areas.

2.
J Hazard Mater ; 383: 121177, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31648122

RESUMO

Low molecular weight organic acids (LMWOA) involved in heavy metal tolerance, translocation, and accumulation in plants. However, underlying mechanism of LMWOA secretion in metal mobilization and uptake in hyperaccumulator still need to be identified. In this study, a 13C labeling rhizobox was designed to investigate the composition and distribution of LMWOA in the rhizosphere of S. alfredii. The result showed that about 2.30%, 2.25% and 2.35% of the assimilated 13C was incorporated into oxalic acid, malic acid, and tartaric acid in rhizosphere of S. alfredii after 13CO2 assimilation, respectively. Oxalic acid, malic acid, and tartaric acid were the predominant LMWOA in rhizosphere soil solution of hyperaccumulating ecotype (HE) S. alfredii, however, almost no tartaric acid was detected for non-hyperaccumulating ecotype (NHE). Tartaric acid was identified as the unique root exudate from HE S. alfredii which was mainly distributed within the range of rhizosphere 0-6 mm. Tartaric acid significantly increased the solubility of four Cd minerals. HE S. alfredii treated with tartrate + CdCO3 had higher Cd contents and larger biomass than CdCO3 treatment. Cadmium accumulation in HE S. alfredii was promoted by the exudation of tartaric acid, which was highly efficient in Cd solubilization due to the formation of soluble Cd-tartrate complexes.

3.
Mol Plant Pathol ; 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31774224

RESUMO

As an obligate parasite, Puccinia striiformis f. sp. tritici (Pst) forms haustoria to obtain nutrients from plant cells for development, and these structures are essential for pathogen survival. To better understand the contribution of haustoria to the interactions with the host plants, we isolated haustoria from susceptible wheat leaves infected with Pst race CYR31 and sequenced their transcriptome as well as those of urediospores and germ tubes, and compared the three transcriptomes. A total of 3524 up-regulated genes were obtained from haustoria, of which 73 genes were related to thiamine biosynthesis, glycolysis and lipid metabolic processes. Silencing seven of the genes reduced the growth and development of Pst in wheat. More interestingly, 1197 haustorial secreted proteins (HASPs) were detected in haustoria, accounting for 34% of the total proteins, indicating that these HASPs play important roles in haustorium-mediated pathogenic progression. Furthermore, 69 HASPs were able to suppress Bax-triggered programmed cell death in tobacco. Additionally, 46 HASPs significantly reduced callose deposition in wheat using the type III secretion system. This study identified a large number of effectors through transcriptome sequencing, and the results revealed components of metabolic pathways that impact the growth and colonization of the pathogen and indicate essential functions of haustoria in the growth and pathogenicity of Pst.

4.
J Hazard Mater ; : 121645, 2019 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-31740314

RESUMO

Nitrocellulose (NC) has been applied in many fields of daily life and military industry, but its instability brings large danger during storage and usage, which greatly limits its application. In this study, decomposition behavior and reaction model of NC were explored. To obtain its kinetic triplets during decomposition, NC samples were heated in nitrogen atmosphere with different heating rates of 5, 10, 15, 20 °C min-1, respectively. A 3-th order reaction model was obtained by model fitting methods. Meanwhile, the relationship between activation energy and conversion was obtained by multi isoconversional methods, including KAS, FR, FWO, and Advanced Vyazovkin methods. Then the reaction model was reconstructed by introducing adjustment functions with result of an expression of f(α) = 19.38193α1.41177(1-α)4.60503.

5.
Mol Med Rep ; 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31746352

RESUMO

Mesenchymal stem cells (MSCs) are used to investigate regeneration and differentiation. MicroRNA­204 (miR­204) in involved in the Runt­related transcription factor 2/alkaline phosphatase/bone morphogenic protein 2 (Runx2/ALP/BMP2) signaling pathway that regulates bone marrow mesenchymal stem cell (BMSC) differentiation; however, the mechanisms underlying the effects of miR­204 are yet to be determined. The aim of the present study was to investigate the effects of miR­204 on BMSC differentiation. BMSCs were derived from rat bone marrow. The expression levels of Runx2, ALP and BMP2 were measured via reverse transcription­quantitative polymerase chain reaction and western blot analyses following transfection of BMSCs with miR­204 agomir or BMP2 expression vector. The ability of the miR­204 gene to directly bind BMP2 mRNA was assessed using dual­luciferase assays. Ossification was measured via alizarin red stain assays. It was observed that the expression levels of Runx2 and ALP increased over time, whereas those of miR­204 decreased; additionally, miR­204 agomir upregulation inhibited the expression of Runx2, ALP and BMP2 in BMSCs. It was revealed that miR­204 directly interacted with BMP2 mRNA, and that transfection with miR­204 agomir suppressed ossification in BMSCs by targeting the BMP2/Runx2/ALP signaling pathway.

6.
ChemSusChem ; 2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31696615

RESUMO

The rapid development of aqueous zinc-ion batteries poses a challenge to the exploration of cathode materials with high capacity and long-cycle life. The organic materials are considered to be the proper choice due to their structural flexibility and tunable surface chemistry. However, most of the organic cathode materials still have some shortcomings of low electrical conductivity, high cost and limited cycling durability. Here, we reported a facile synthesis of the novel organic composite cathode of cross-conjugated polycatechol (PC) combined with graphene (PC/G) for aqueous zinc-ion storage, in which plenty of hydroxyl groups in PC/G composite cathode can be converted to the redox-active carbonyl groups at the initial discharge/charge. Such a composite cathode can deliver a high specific capacity of 355 mAh g -1 at 0.1 C and a specific capacity of 171 mAh g -1 at 10 C. Moreover, the composite cathode can remain 74.4% of initial capacity after 3000 discharge/charge cycles at 2 C. This coordination way to zinc-ion within the PC/G composite cathode can avoid the structural destruction of cathode material during discharge/charge. Such an organic cathode shows great promise for reversible zinc-ion storage, which brings the aqueous zinc-ion batteries a step closer to their future practical applications.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31741374

RESUMO

Scintillators that convert ionization radiation photons to UV-visible photons have attracted extraordinary attention. Traditional scintillators are associated with a vacuum photomultiplier tube that facing strict constraints of fragility, magnetic fields and operated voltage, or coupled to a silicon photomultiplier (SiPM) with optical silicone grease. Here, we report a high-performance radiation detector with an indirect photon-to-photon conversion radiation detection model based on perovskite single crystals, which perovskite single crystals have been directly integrated into the window of SiPM by using solution growth method at low temperature. Tunable X (γ)-ray excited light emission in a range from 414 to 600 nm is obtained with different concentrations of Br doping, which greatly matches the response wavelength of SiPM. Small Br doped CH3NH3PbBr0.05Cl2.95 single crystals exhibit high transmittance and weak self-absorption, resulting in improved scintillation light emissions. Moreover, we have successfully collected a 137Cs source gamma-ray pulse height spectrum with SiPM readout. The MAPbBr0.05Cl2.95 scintillator exhibits the decay time of 0.14±0.02 ns and light yield of 18000Photons/MeV with the energy resolution of 10.5±0.4% at 662keV. The results indicate that the CH3NH3PbBrxCl3-x perovskite single crystals could enable the next generation of low-cost, fast, and fine energy resolution scintillator.

8.
Chem Soc Rev ; 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31742279

RESUMO

Nitrogen is a fundamental constituent for all living creatures on the Earth and modern industrial society. The current nitrogen industry is largely powered by fossil fuels with huge energy consumption and carbon dioxide emission, and nitrogen pollution in surface water bodies induced by the indiscriminate discharge of industrial and domestic wastewater has become a worldwide environmental concern. Electrochemical techniques for nitrogen fixation and transformation under mild conditions are promising approaches to meet the challenge of efficiently managing and balancing the nitrogen cycle, where the rational design of advanced electrocatalysts from both structural and compositional aspects down to the nanoscale plays the most essential role. Herein, important nitrogen species including dinitrogen (N2), ammonia (NH3) and hydrazine (N2H4), their transformation processes between each other including the nitrogen reduction reaction (NRR), ammonia oxidation reaction (AOR) and hydrazine oxidation reaction (HzOR), and research progress on the development of related electrocatalysts are systematically summarized, aiming at establishing a general picture of the whole nitrogen cycle instead of a certain single reaction. Strategies combining theoretical computations and experimental optimizations are proposed to improve the catalytic performance including activity, efficiency, selectivity and stability, finally contributing to a self-sufficient and carbon-free "green" nitrogen economy.

9.
Genome Biol ; 20(1): 243, 2019 11 19.
Artigo em Inglês | MEDLINE | ID: mdl-31744513

RESUMO

BACKGROUND: DNA methylation can provide a source of heritable information that is sometimes entirely uncoupled from genetic variation. However, the extent of this uncoupling and the roles of DNA methylation in shaping diversity of both gene expression and phenotypes are hotly debated. Here, we investigate the genetic basis and biological functions of DNA methylation at a population scale in maize. RESULTS: We perform targeted DNA methylation profiling for a diverse panel of 263 maize inbred genotypes. All genotypes show similar levels of DNA methylation globally, highlighting the importance of DNA methylation in maize development. Nevertheless, we identify more than 16,000 differentially methylated regions (DMRs) that are distributed across the 10 maize chromosomes. Genome-wide association analysis with high-density genetic markers reveals that over 60% of the DMRs are not tagged by SNPs, suggesting the presence of unique information in DMRs. Strong associations between DMRs and the expression of many genes are identified in both the leaf and kernel tissues, pointing to the biological significance of methylation variation. Association analysis with 986 metabolic traits suggests that DNA methylation is associated with phenotypic variation of 156 traits. There are some traits that only show significant associations with DMRs and not with SNPs. CONCLUSIONS: These results suggest that DNA methylation can provide unique information to explain phenotypic variation in maize.

10.
Medicine (Baltimore) ; 98(44): e17740, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689822

RESUMO

To identify independent factors associated with prolonged hospital length of stay (LOS) in elderly patients undergoing first-time elective open posterior lumbar fusion surgery.We retrospectively analyzed the data of 303 elderly patients (age range: 60-86 years) who underwent first-time elective open lumbar posterior fusion surgery at our center from December 2012 to December 2017. Preoperative and perioperative variables were extracted and analyzed for all patients, and multivariate stepwise regression analysis was used to determine the variables affecting the LOS and important predictors of LOS prolongation (P < .001).The mean age of the patients was 67.0 ±â€Š5.5 years, and the mean LOS was 18.5 ±â€Š11.8 days, ranging from 7 to 103 days. Of the total, 166 patients (54.8%) were men and 83 patients (27.4%) had extended LOS. Multiple linear regression analysis determined that age (P < .001), preoperative waiting time ≥7 days (P < .001), pulmonary comorbidities (P = .010), and diabetes (P = .010) were preoperative factors associated with LOS prolongation. Major complications (P = .002), infectious complications (P = .001), multiple surgeries (P < .001), and surgical bleeding (P = .018) were perioperative factors associated with LOS prolongation. Age (P < .001), preoperative waiting time ≥7 days (P < .001), infectious complications (P < .001), and multiple surgeries (P < .001) were important predictors of LOS prolongation.Extended LOS after first-time elective open posterior lumbar fusion surgery in elderly patients is associated with factors including age, preoperative waiting time, infectious complications, and multiple surgeries. Surgeons should recognize and note these relevant factors while taking appropriate precautions to optimize the modifiable factors, thereby reducing the LOS as well as hospitalization costs.


Assuntos
Procedimentos Cirúrgicos Eletivos/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Fusão Vertebral/estatística & dados numéricos , Fatores de Tempo , Tempo para o Tratamento/estatística & dados numéricos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Procedimentos Cirúrgicos Eletivos/métodos , Feminino , Humanos , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Complicações Pós-Operatórias/etiologia , Período Pré-Operatório , Análise de Regressão , Estudos Retrospectivos , Fatores de Risco , Fusão Vertebral/efeitos adversos , Fusão Vertebral/métodos , Listas de Espera
11.
J Exp Bot ; 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31728522

RESUMO

Proanthocyanidins (PAs, or condensed tannins) are a major class of important flavonoids that contribute to citrus fruit quality. However, the molecular mechanism responsible for PA biosynthesis and accumulation in citrus remains unclear. Here, we identified the CsPH4-Noemi regulatory complex, which regulates PA biosynthesis in citrus. Overexpression of CsPH4 or Noemi in citrus calli activated the expression of PA biosynthetic genes and significantly increased the PA content. Interestingly, Noemi was also shown to be upregulated in CsPH4-overexpressing lines compared to wild-type calli. Simultaneously, CsPH4 partially complemented the PA-deficient phenotype of the Arabidopsistt2 mutant and promoted PA accumulation in the wild-type. Further analysis revealed that CsPH4 interacted with Noemi, and together, these proteins synergistically activated the expression of PA biosynthetic genes by directly binding to the MYB-recognizing elements (MRE) of the promoters of these genes. Moreover, CsPH4 could directly bind to the promoter of Noemi and upregulate the expression of this gene. These findings explain how the CsPH4-Noemi regulatory complex contributes to the activation of PA biosynthetic genes via a positive feedback loop and provide new insights into the molecular mechanisms underlying PA biosynthesis, which can be effectively employed for metabolic engineering of PAs to improve citrus fruit quality.

12.
Chem Asian J ; 14(20): 3450-3451, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31613062

RESUMO

What a collection! This special issue contains latest works on MOFs and MOF-based materials from various research groups from across the world.

13.
Eur J Med Chem ; 184: 111750, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31610376

RESUMO

Developing small molecules occupying the heme-binding site using computational approaches remains a challenging task because it is difficult to characterize heme-ligand interaction in heme-containing protein. Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular heme-containing dioxygenase which is associated with the immunosuppressive effects in cancer. With IDO1 as an example, herein we report a combined virtual screening (VS) strategy including high-specificity heme-binding group (HmBG)-based pharmacophore screening and cascade molecular docking to identify novel IDO1 inhibitors. A total of four hit compounds were obtained and showed proper binding with the heme iron coordinating site. Further structural optimization led to a promising compound S18-3, which exerted potent anti-tumor efficacy in BALB/c mice bearing established CT26 tumors by activating the host's immune system. These results suggest that S18-3 merits further study to assess its potential for the intervention of cancer. Furthermore, our study also unveils a novel in silico-based strategy for identifying potential regulators for hemeproteins within short timeframe.

14.
Hum Brain Mapp ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31571368

RESUMO

It is unclear how the brain network changed after kidney transplantation (KT). We explored the patterns of large-scale complex network after KT in end-stage renal disease (ESRD) patients with resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI). Twenty-one ESRD patients (14 men; mean age, 31.5 ± 9.9 years) scheduled for KT and 17 age- and gender-matched healthy controls (HC) (8 men; mean age, 28.9 ± 7.2 years) were enrolled in this study. Each participant underwent rs-fMRI and DTI scans in three time points (pre-KT, 1 and 6 months after KT [for ESRD]). Graph theory analysis was used to characterize the topological properties by using functional and structural network connectivities intergroup correlation analysis was performed between functional/structural MR indexes and clinical markers. Compared with HC, pre-KT ESRD patients showed an altered topological organization in both functional and structural networks. Compared with pre-KT, increased node degree and node efficiency were observed for both functional and structural networks at 1 month after KT (all p < .05), which were further increased at 6 months after KT (p < .05). Both functional and structural networks did not recover completely at 6 months after KT (all p < .05). The patients showed an increased functional-structural connectivity coupling at 1 month after KT compared with HC (p = .041). A trend of progressive recovery of functional and structural connectivity networks was observed in ERSD patients after KT, which did not recover to the normal levels even in 6 months after KT. The study results underlie cognitive function recovery in ESRD patients following KT in the neuropathophysiological perspective.

15.
Plant Cell Physiol ; 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31642503

RESUMO

Anthocyanins are preferentially accumulated in certain tissues of particular species in citrus. A R2R3-MYB transcription factor (named as Ruby1) has been well documented as an activator of citrus anthocyanin biosynthesis. Here, we characterized CsMYB3, a transcriptional repressor that regulates anthocyanin biosynthesis in citrus. CsMYB3 was expressed in anthocyanin pigmented tissues and the expression was closely associated with that of Ruby1, which is a key anthocyanin activator. Overexpression of CsMYB3 in Arabidopsis resulted in a decrease in anthocyanins under nitrogen stress. Overexpression of CsMYB3 in the background of CsRuby1-overexpressing strawberry and Arabidopsis reduced the anthocyanin accumulation level. Transient promoter activation assays revealed that CsMYB3 could repress the activation capacity of the complex formed by CsRuby1/CsbHLH1 for the anthocyanin biosynthetic genes. Moreover, CsMYB3 could be transcriptionally activated by CsRuby1 via promoter binding, thus forming an 'activator-and-repressor' loop to regulate anthocyanin biosynthesis in citrus. This work shows that CsMYB3 plays a repressor role in the regulation of anthocyanin biosynthesis, and proposes an 'activator-and-repressor' loop model constituted by CsRuby1 and CsMYB3 in the regulation of anthocyanin biosynthesis in citrus.

16.
BMC Infect Dis ; 19(1): 869, 2019 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-31640582

RESUMO

BACKGROUND: Pandoraea species is a newly described genus, which is multidrug resistant and difficult to identify. Clinical isolates are mostly cultured from cystic fibrosis (CF) patients. CF is a rare disease in China, which makes Pandoraea a total stranger to Chinese physicians. Pandoraea genus is reported as an emerging pathogen in CF patients in most cases. However, there are few pieces of evidence that confirm Pandoraea can be more virulent in non-CF patients. The pathogenicity of Pandoraea genus is poorly understood, as well as its treatment. The incidence of Pandoraea induced infection in non-CF patients may be underestimated and it's important to identify and understand these organisms. CASE PRESENTATION: We report a 44-years-old man who suffered from pneumonia and died eventually. Before his condition deteriorated, a Gram-negative bacilli was cultured from his sputum and identified as Pandoraea Apista by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). CONCLUSION: Pandoraea spp. is an emerging opportunistic pathogen. The incidences of Pandoraea related infection in non-CF patients may be underestimated due to the difficulty of identification. All strains of Pandoraea show multi-drug resistance and highly variable susceptibility. To better treatment, species-level identification and antibiotic susceptibility test are necessary.

17.
Int J Nanomedicine ; 14: 8121-8132, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632022

RESUMO

Introduction: Exosomes are important mediators of intercellular communication. Previously, we characterized circulating exosomal miR-425-3p as a non-invasive prognostic marker for predicting clinical response to platinum-based chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods: Circulating exosomal miR-425-3p was validated by qRT-PCR in paired serum samples from NSCLC patients during the course of platinum-based chemotherapy. Cell coculture was performed to examine the effects of exosomal miR-425-3p on the sensitivity of recipient A549 cells to cisplatin. Using bioinformatics, ChIP and luciferase reporter assays, the transcription factor essential for miR-425-3p expression was identified. Autophagic activity in the recipient cells was determined by Western blot and fluorescence microscopy. Results: Higher levels of exosomal miR-425-3p were found in serum samples from the patients in tolerance versus those at baseline. An upward trend in the expression of circulating exosomal miR-425-3p was revealed during chemotherapy. Furthermore, the expression of exosomal miR-425-3p could be induced by cisplatin in NSCLC cells. Exosomes isolated from either cisplatin-treated or cisplatin-resistant NSCLC cells conferred chemoresistance to sensitive A549 cells in a miR-425-3p-dependent manner. Cisplatin-induced c-Myc was found to directly bind the miR-425-3p promoter and transactivated its expression. Exosomal miR-425-3p facilitated autophagic activation in the recipient cells by targeting AKT1, eventually leading to chemoresistance. Discussion: Our results suggest that apart from a prognostic marker of treatment response, exosomal miR-425-3p might be a potential dynamic biomarker to tailor cisplatin resistance in NSCLC patients during the treatment and represent a promising therapeutic target for therapy-resistant NSCLC.

18.
Dis Markers ; 2019: 3862024, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31636735

RESUMO

Background and Aim: Serum Golgi protein 73 (GP73) is a promising alternative biomarker of chronic liver diseases, but most data are from patients with HBV infection rather than HCV. Materials and Methods: Two independent cohorts of chronic hepatitis C (CHC) patients from the 5th Medical Centre of the Chinese PLA General Hospital (n = 174) and Beijing Youan Hospital (n = 120) with different histories of HCV infection were enrolled. The correlations between serum GP73 and other biochemical indices, as well as its correlations with different stages of liver disease progression, were investigated. The receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic potential of serum GP73 for liver necroinflammation and fibrosis, and comparisons of the diagnostic efficiency with traditional indices of hepatic liver injuries were further investigated. Results: Levels of serum GP73 were found significantly elevated in patients with moderate to severe inflammatory grade (G ≥ 2) and/or with advanced fibrotic stages (F ≥ 3) in both cohorts (P < 0.05, respectively), as compared to those with a normal or mild liver lesion. Further ROC analysis demonstrated that serum GP73 was comparable to serum ALT and AST in diagnosing the liver necroinflammation grade at G ≥ 2, but its diagnostic values for advanced fibrosis (F ≥ 3) and cirrhosis (F = 4) were limited when compared to APRI and FIB-4, and FIB-4 exhibited the best performance. Notably, an obvious elevation of serum GP73 was observed after patients received PEG-IFN and ribavirin treatment. Conclusions: Serum GP73 is an important biomarker in evaluating and monitoring the disease progression including liver necroinflammation and fibrosis in patients with chronic HCV infection, but the value is limited for diagnosing advanced fibrosis and cirrhosis in comparison with APRI and FIB-4.

19.
Medicine (Baltimore) ; 98(42): e17341, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31626091

RESUMO

RATIONALE: Schwannomas grow slowly, originating from the Schwann cells of the nerve sheath. Schwannomas of cranial origin have the highest incidence, followed by intraspinal schwannomas. However, paravertebral schwannoma is rare, and to our knowledge, giant paravertebral schwannomas near the lumbar nerve roots with bone destruction are extremely rare. PATIENT CONCERNS: A 47-year-old Chinese woman complained of lower back soreness and a sensation of a bulging lumbar disc with no obvious cause for the past 3 years. DIAGNOSIS: Lumbar magnetic resonance imaging showed a large mass with uneven density, 17 × 12 × 15 cm in size, located to the right of the 4th lumbar with obvious bony destruction. Histopathology and immunohistochemistry confirmed that this mass was a benign schwannoma. INTERVENTIONS: Complete resection of the tumor (measuring about 17 × 12 × 15 cm in size) and vertebral reconstruction using internal fixation were performed. OUTCOMES: The patient was discharged without complications after surgery. The 3-year follow-up revealed that the patient recovered well with no evidence of recurrence. LESSONS: Here, we emphasize the importance of careful radiological examination and reflect on the difficulty of tumor resection. Furthermore, understanding the treatment and diagnosis of lumbar paravertebral schwannoma is critical for plastic surgeons and radiologists when encountering similar cases.


Assuntos
Vértebras Lombares/patologia , Neurilemoma/patologia , Neoplasias da Coluna Vertebral/patologia , Raízes Nervosas Espinhais/patologia , Feminino , Humanos , Dor Lombar/etiologia , Vértebras Lombares/virologia , Região Lombossacral/diagnóstico por imagem , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Neurilemoma/diagnóstico por imagem , Neurilemoma/cirurgia , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Neoplasias da Coluna Vertebral/cirurgia , Raízes Nervosas Espinhais/diagnóstico por imagem , Raízes Nervosas Espinhais/cirurgia , Resultado do Tratamento
20.
Appl Opt ; 58(19): 5143-5147, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31503607

RESUMO

We have experimentally demonstrated a wavelength-tunable passively mode-locked all-fiber laser at 1.5 µm wavelength by using an erbium-doped fiber amplifier, a fiber-pigtailed semiconductor saturable absorber mirror, and a tunable birefringence Sagnac filter. In our work, by properly setting the polarization state of the propagating light in the birefringence Sagnac filter, the mode-locked lasing wavelength can be continuously tuned from 1544.1 to 1560.8 nm, corresponding to a tuning range of 16.7 nm. At a central wavelength of 1548.5 nm, the fiber laser delivers pulses as short as 713.2 fs with a repetition rate of 4.65 MHz, a 3 dB bandwidth of 5.7 nm, and an average output power of 4.86 mW. Our results show that such a mode-locked all-fiber laser has great potential in applications in nonlinear optics at the 1.5 µm band.

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