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1.
Medicine (Baltimore) ; 99(20): e20231, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32443355

RESUMO

BACKGROUND: To systematically evaluate the effects of physical activity on physiological markers in breast cancer survivors. METHODS: A systematic search of the PubMed, Wed of Science, Medline, CNKI and Wanfang Database was performed to identify eligible randomized controlled trials to explore physical activity on physiological markers in breast cancer survivors. STATA version 13.0 (Stata Corp LP, College Station, TX) was used for all statistical analyses. RESULTS: A total of 11 articles with 941 cases were eligible in this meta-analysis. The results of the meta-analysis showed that physical activity could decrease the levels of insulin (SMD = -1.90, 95%CI: -3.2 to -0.60; I = 92.3%, P < .001), insulin-like growth factor 1 (IGF-I) (WMD = -4.67, 95%CI: -23.14 to 13.79; I = 96.2%, P < .001), insulin-like growth factor binding protein-3 (IGFBP-3) (WMD = -20.09, 95%CI: -47.15 to 6.97; I = 93.3%, P < .001). However, compared with the control group, there was not the significant change of insulin-like growth factor 2 (IGF-II), insulin-like growth factor binding protein-1 (IGFBP-1), leptin, adiponectin, glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-ɑ) levels after the intervention. CONCLUSIONS: Physical activity could improve the insulin function that might be associated with decreasing the levels of IGF-I, IGFBP-3 and insulin in breast cancer survivors.

2.
Environ Int ; 141: 105753, 2020 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-32417613

RESUMO

BACKGROUND: Environmental hexavalent chromium contamination in northeast China has been ongoing for over 60 years and health outcomes related with chromium (Cr) pollution were observed in polluted arears, but exposure pathways remains unclear. This study aims to evaluate the association between Cr exposure dose through multiple exposure pathways and Cr concentration in urine, and identify the most contributed pathway. METHODS: We used risk assessment tools with individual exposure parameters to estimate eight individual Cr exposure doses (CD) for three exposure routes (inhalation, ingestion, and dermal contact) with four environmental media (underground water, soil, household dust, and PM10 in ambient air) in 134 residents living in three chromium polluted villages. We used the covariate-adjusted standardized urinary Cr concentration (casUCr) as the internal Cr exposure biomarker. Ridge Regression, Weighted Quantile Sum Regression (WQS) and Bayesian Kernel Machine Regression (BKMR) models were used to assess the effect of overall eight CDs on urine Cr concentration and compare the contribution of each CD. RESULTS: In the ridge regression analysis, Cr exposure through ingestion of dust (ßstd = 0.418, p-value = 0.009), inhalation of dust (ßstd = 0.384, p = 0.031) and dermal contact with soil (ßstd = 0.264, p = 0.192) had the highest impact on casUCr. In the WQS model, the overall CDs demonstrated a non-significant positive association with casUCr. CDs of dust ingestion, air inhalation and dust inhalation had the largest contribution on casUCr when fitted in the WQS model. In the BKMR model, the hierarchical variable selection showed that casUCr was mainly affected by CDs of household dust and dermal contact with soil. CD of dermal contact with soil exhibited a negative association with casUCr, while CDs of dust showed positive or non-linear trend. CONCLUSIONS: This research proposed a new method to calculate individual Cr exposure dose of multi-pathway and applied different statistical methods to identify predominant pathway. For this study, Cr exposure through dust has the strongest effect on Cr concentration in urine. The results could help conduct target interventions to reduce Cr intake, such as blocking dust exposure to reduce Cr uptake for villagers living in these contaminated areas.

3.
Dalton Trans ; 2020 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-32073059

RESUMO

A major challenge in the field of photocatalytic carbon dioxide (CO2) reduction is to design catalyst systems featuring high selectivity for CO production, long-term stability and a composition of Earth-abundant elements. Here, we present a metal-organic framework (MOF) based catalyst to mitigate the technical problems associated with the above-mentioned features. We report a carbon-coated CuNi alloy nanocatalyst obtained by high temperature vacuum treatment of a MOF material (CuNiBTC). The resulting carbon encapsulated CuNi (denoted as CuNi/C) nanoparticles possess a well-designed core-shell composite structure with graphene shells. Meanwhile, we investigated the reaction mechanism of CO2 on the surface of the CuNi/C photocatalyst in an aqueous solution containing triethanolamine. The experimental results show that the activity and catalytic yield of CuNi/C are much higher than those of Cu/C and Ni/C alone. At the same time, the catalytic activity of CuNi/C is also affected by changing the reaction temperature in the preparation process. As a result, the CuNi/C samples can achieve nearly 90% selectivity for NIR-light-driven CO2 reduction to CO. Our approach demonstrates the potential of non-semiconductor materials as catalysts for efficient and selective reduction of CO2 to CO.

4.
Dalton Trans ; 49(7): 2048-2052, 2020 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-31989128

RESUMO

This Frontier presents the recent developments and applications of two-dimensional (2D) amorphous transition metal oxides (TMOs) obtained by using supercritical CO2. CO2 molecules can affect the crystal transformation of layered materials and allow diffusive atomic disordering during the exfoliation process. If amorphous structures are introduced into TMOs, the strong localization tail states that exist in the band gap of TMOs can effectively promote chemical reactions. We also discuss the future challenges to be overcome for this class of supercritical CO2 and 2D amorphous materials.

6.
Angew Chem Int Ed Engl ; 59(8): 3322-3328, 2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-31850648

RESUMO

In two-dimensional (2D) amorphous nanosheets, the electron-phonon coupling triggered by localization of the electronic state as well as multiple-scattering feature make it exhibit excellent performance in optical science. VS2 nanosheets, especially single-layer nanosheets with controllable electronic structure and intrinsic optical properties, have rarely been reported owing to the limited preparation methods. Now, a controllable and feasible switching method is used to fabricate 2D amorphous VS2 and partial crystallized 2D VO2 (D) nanosheets by altering the pressure and temperature of supercritical CO2 precisely. Thanks to the strong carrier localization and the quantum confinement, the unique 2D amorphous structures exhibit full band absorption, strong photoluminescence, and outstanding photothermal conversion efficiency.

7.
Alzheimers Dement (Amst) ; 11: 721-729, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31700990

RESUMO

Introduction: Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods: We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. Results: PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion: PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.

8.
Chem Commun (Camb) ; 55(88): 13307-13310, 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31626252

RESUMO

In this work, Au nanoparticles (NPs) grown on defective WO3-x (Au/WO3-x) show superior electrocatalytic N2 reduction activity under ambient conditions in 0.1 M KOH. At -0.2 V versus the reversible hydrogen electrode (vs. RHE), the Au/WO3-x catalyst achieves a large NH3 yield of 23.15 µg h-1 mg-1 and a high faradaic efficiency (FE) of 14.72%. Further density functional theory (DFT) calculations indicate that electron transfer between the Au nanoparticles and defective WO3-x promotes the activation of N2 molecules effectively.

9.
Chem Commun (Camb) ; 55(83): 12527-12530, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31576838

RESUMO

Amorphous MoO3-x with enhanced LSPR has been fabricated successfully by introducing Mo atoms into the interlayers of MoO3 nanosheets via a hydrothermal method. The inserted Mo atom could bond with inherent Mo atoms and further form a distorted atomic configuration structure. Thus, the amorphous MoO3-x possesses a relatively excellent photothermal conversion efficiency of 61.79%.

10.
Environ Sci Pollut Res Int ; 26(33): 34479-34486, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31642019

RESUMO

Diabetes mellitus (DM) is a common chronic disease worldwide. Ambient air pollution has long been proven to be associated with type 2 diabetes mellitus (T2DM) progression, but the underlying mechanism is not clear yet. In addition, previous studies mainly focused on the prevention of healthy people against the incidence of T2DM. We designed a panel study including two follow-ups and enrolled 39 patients with T2DM living in Beijing. Linear mixed model was fitted to assess the association between two pairs of variables (ambient air pollution exposure and C3 levels, ambient air pollution exposures and T2DM index). Mediation analysis of C3 between ambient air pollution exposure and indicators of T2DM progression was conducted. We found that PM2.5 exposures is are negatively associated with serum complement C3. Given that C3 might act as a protector of pancreas ß cell, PM2.5 exposures could accelerate disease in T2DM populations. No mediation effects were found. This study reveals that exposures to PM2.5 can cause progression of diseases among T2DM populations.


Assuntos
Poluição do Ar/estatística & dados numéricos , Complemento C3/metabolismo , Diabetes Mellitus Tipo 2/epidemiologia , Exposição Ambiental/estatística & dados numéricos , Material Particulado/análise , Idoso , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Pequim , China/epidemiologia , Exposição Ambiental/análise , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade
11.
Environ Int ; 133(Pt A): 105135, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31491592

RESUMO

BACKGROUND: Little information exists on the lipidemic effects of ozone exposure. Few studies have focused on the different patterns of the association among older adults population, and little attention has been given to comprehensive lipid indices when evaluating the effect of O3 exposure on the metabolism. METHODS: We conducted a longitudinal study involving 201 older adults in Beijing, China between 2016 and 2018. A mixed regression model was applied with random effects to investigate the relationship between O3 and lipid profiles. RESULTS: O3 exposure positively correlated with TC, LDL-C, CRI-I, CRI-II and AC at short-term and medium-term exposure periods. The largest increases in TC, LDL-C, CRI-I and CRI-II were found in the 28-days moving average indicating accumulative effects over prolonged exposure period. A 10 µg/m3 increase of O3 at the 28-days moving average was associated with a significant increase of 3.9% (95% CI: 1.0, 6.9) in TC, 8.2% (95% CI: 4.2, 12.4) in LDL-C, 4.8% (95% CI: 1.1, 8.5) in CRI-I and 7.0% (95% CI: 2.7, 11.5) in CRI-II. Stratification by health status and characteristics revealed different patterns of lipid changes among older adults, lipid status, age, sex and BMI may modify the relationship between O3 exposure and lipid profiles. CONCLUSIONS: Our findings suggest that short-term and medium-term O3 exposure is associated with lipid profiles abnormalities among the older adults. Evidence also suggests there are patterns within population which differ according to both health status and demographic characteristics.


Assuntos
Poluentes Atmosféricos/farmacologia , Metabolismo dos Lipídeos , Ozônio/farmacologia , Idoso , Poluentes Atmosféricos/análise , Pequim , Exposição Ambiental , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade
12.
Allergy Asthma Proc ; 40(5): 343-349, 2019 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-31514793

RESUMO

Background: Hereditary angioedema (HAE) is still underdiagnosed or diagnosed after a serious delay. This study aimed to evaluate the diagnostic delay (DD) and misdiagnosis of HAE, and to explore the risk factors associated with a longer DD. Methods: An Internet-based survey was sent to 129 patients with type 1 and 2 HAE who presented to the Allergy Department, Peking Union Medical College Hospital between 1983 and 2017; 107 patients (82.9%) responded, among whom, a total of 96 patients provided complete information about medical visits. DD was divided into two subperiods according to the lower quartile, i.e., DD ≤ 6 years and DD > 6 years. Results: The median DD of all 96 patients with HAE was 11.04 years (interquartile range [IQR], 6.06-18.27 years). A significant difference (p < 0.001) in the median DD was found between different decades of onset, i.e., before 1999 (19.75 years [IQR, 13.58-29.50 years]), between 2000 and 2009 (8.67 years [IQR, 5.67-11.04 years]), and between 2010 and 2017 (3.79 years [IQR, 2.29-5.71 years]). Patients with a previous misdiagnosis experienced a longer median delay to complement 1 inhibitor HAE diagnosis (13.17 years [IQR, 7.40-20.50 years]) compared with patients without a previous misdiagnosis (median 6.96 years [IQR, 2.83-10.65 years]; p ≤ 0.001). According to the logistic regression analysis, a younger age of onset and earlier decade of onset were significant predictors of a DD of >6 years. The most frequently visited departments and most frequently misdiagnosed diseases were summarized. Conclusion: The median DD of patients with HAE was 11.04 years (IQR, 6.06-18.27 years). A younger age of onset and earlier decade of onset were predictors of a DD of >6 years. Seventy-five percent of the patients reported receiving more than one previous misdiagnosis. The patients with a previous misdiagnosis had longer DDs compared with patients without a misdiagnosis.

13.
Chem Commun (Camb) ; 55(68): 10174-10177, 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31389934

RESUMO

A tri-metal material system of FeCoNi-based nitro-sulfide (FeCoNi-NS) hierarchical structure has been successfully synthesized via a deep eutectic solvent annealing process. The as-prepared FeCoNi-NS possesses interesting N,S-binary heteroatoms evenly doped with Fe, Co, and Ni. By taking advantage of the unique structure including multi-metal sites, high BET area and porous structures, the as-prepared FeCoNi-NS exhibited excellent oxygen evolution reaction (OER) performance, achieving a current density of 10 mA cm-2 at an overpotential of 251 mV and a low Tafel slope of 58 mV dec-1 in 1 M KOH. Furthermore, FeCoNi-NS also demonstrated highly efficient mass/charge transportation, long-term stability with 2% deactivation after ten hours continuous operation and high faradaic efficiency of 98%. Such a facile synthetic strategy is applicable to the fabrication of more mutil-metal hierarchical structures for energy conversion and storage.

14.
Orphanet J Rare Dis ; 14(1): 191, 2019 08 08.
Artigo em Inglês | MEDLINE | ID: mdl-31395105

RESUMO

BACKGROUND: Hereditary angioedema (HAE) is a rare but serious condition characterized by unpredictable and recurrent attacks affecting the skin and mucosa. HAE has wide-ranging impacts on the health-related quality of life (HRQoL) of patients. This study aims to assess the HRQoL of Chinese patients with HAE using the 36-item Short Form Health Survey (SF-36v2) and to explore potential risk factors for low HRQoL. METHODS: A total of 104 patients (47 male and 57 female) over age 18 living in China with a known diagnosis of HAE due to C1-INH deficiency completed the SF-36v2 (generic HRQoL questionnaire). The results were compared to Chinese population norms. Subgroup analysis and logistic regression were used to interpret the data. RESULTS: SF-36v2 showed a significant reduction in all dimensions of HRQoL (p < 0.001) in patients with HAE compared with the general Chinese population. Female patients reported significantly lower bodily pain (BP) (p = 0.039) and physical component scores (PCSs) (p = 0.027) than male patients. Patients with mucosal edema tended to report lower role-physical (RP) limitations (p = 0.031) than patients with only skin edema. There were no differences between the mean scores of the SF-36 in relation to disease subtype, age, disease severity and long-term prophylaxis. Among female patients on long-term prophylaxis, social functioning (SF) (r = - 0.404, p = 0.010), role-emotional (RE) (r = - 0.320, p = 0.044) and mental component scores (MCSs) (r = - 0.313, p = 0.049) were negatively correlated with danazol dosage. A correlation between decreased disease control and decreased HRQoL scores was found, although the correlation was not significant in terms of RE or mental health (MH) scores. The logistic regression model revealed uncontrolled disease to be a risk factor for a low PCS (odds ratio 10.77, 95% confidence interval [CI] 1.78-65.06; p = 0.010) and laryngeal edema to be a risk factor for a low MCS (odds ratio 4.75, 95% CI 1.09-20.69; p = 0.038). CONCLUSIONS: Chinese HAE patients reported significantly lower HRQoL scores than the general population. Unsatisfactory disease control is a risk factor for decreased PCSs. Laryngeal edema is a risk factor for decreased MCSs.

15.
Stroke Vasc Neurol ; 4(2): 99-101, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31338220

RESUMO

Vascular cognitive impairment (VCI) is a major contributor to age-related dementing illnesses which imposes a tremendous burden on families and society. It is a heterogeneous group of brain disorders. However, cerebral small vessel disease (CSVD) accounts for about 50%-70% of VCI, which represented a more homogeneous subtype of VCI. Advanced multimodal neuroimaging techniques like brain network connectome analyses are currently applied to explore the underlying mechanism of VCI. Some progress in the field of structural and functional brain network researches on a poststroke longitudinal CSVD cohort (Renji CSVD Cohort Study) was reported. Global and regional brain network characters were compared between patients with CSVD and healthy control. It suggested that distributed brain structural network disruption may play a pivot role in the cognitive decline. The results showed that brain structural network characters have distinctive differentiating capacity on the cognition of patients with CSVD.

16.
Chem Commun (Camb) ; 55(66): 9777-9780, 2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31298668

RESUMO

Quasi-metallic NixMoO3 nanodots with an enhanced localized surface plasmon resonance in the visible and NIR regions have been successfully fabricated. DFT calculations reveal the metallic nature of NixMoO3 nanodots. Thus, they exhibit an excellent photothermal conversion efficiency of 87.4%, and have a high water evaporation rate of 2.13 kg m-2 h-1.

17.
Mol Med Rep ; 20(2): 2012-2020, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31257477

RESUMO

The dysregulated behavior of vascular smooth muscle cells (VSMCs) serves an important role in the pathogenesis of cardiovascular diseases in diabetes. The present study aimed to investigate the effects of microRNA (miR)­132 on the proliferation and migration of VSMCs under high glucose conditions to mimic diabetes. We observed that the expression of miR­132 was significantly decreased and that of E2F transcription factor 5 (E2F5) was upregulated in high glucose (HG)­treated VSMCs or those obtained from diabetic rats. A dual luciferase reporter gene assay revealed that miR­132 could specifically bind to the 3'­untranslated region of E2F5 and significantly suppress the luciferase activity. The proliferation and migration of diabetic rat or HG­treated VSMCs were increased compared with non­diabetic rat VSMCs and those under normal glucose conditions. Upregulation of miR­132 significantly inhibited the proliferation and migration of diabetic rat VSMCs; similar effects were observed following E2F5 downregulation. The inhibitory effects of miR­132 on the proliferation and migration of HG­treated VSMCs could be reversed by E2F5 overexpression. In conclusion, miR­132 was proposed to inhibit the proliferation and migration of diabetic rat or high­glucose­treated VSMCs by targeting E2F5. The findings of the present study suggested that increasing the expression of miR­132 may serve as a novel therapeutic approach to inhibit the progression of cardiovascular disease in diabetes.


Assuntos
Fator de Transcrição E2F5/genética , MicroRNAs/genética , Músculo Liso Vascular/metabolismo , Miócitos de Músculo Liso/metabolismo , Animais , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Diabetes Mellitus Experimental/genética , Diabetes Mellitus Experimental/patologia , Regulação da Expressão Gênica/genética , Glucose/farmacologia , Humanos , Músculo Liso Vascular/efeitos dos fármacos , Miócitos de Músculo Liso/efeitos dos fármacos , Proteínas Proto-Oncogênicas c-sis/genética , Ratos
18.
ACS Appl Mater Interfaces ; 11(31): 27798-27804, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31305977

RESUMO

Interface engineering of two-dimensional (2D) transition-metal composites for activating plane and edge sites is a significant yet step challenging in boosting their performance for hydrogen evolution reaction (HER). Herein, two-dimensional (2D) MoO3 with petal-shaped nanosheets confining Pd nanoparticles (Pd@MoO3 heterostructure) was prepared via an efficient solvothermal and subsequently hydrogen reduction processes. The atomically dispersed Pd-substituted sites in the interface of Pd nanoparticles and 2D MoO3 lattices significantly play an important role in enhancing the electrocatalytic and photocatalytic performances of the Pd@MoO3 heterostructure. As a result, the Pd@MoO3 heterostructure exhibits a high HER catalytic activity with an overpotential (η) of 71 mV to achieve a current density of 10 mA cm-2 and an extremely low Tafel slope of 42.8 mV dec-1 in 0.5 M H2SO4 solution. Furthermore, the photoresponse of the Pd@MoO3 heterostructure is about 3 times higher than that of the MoO3 nanosheets. This work highlighted a strategy of interface engineering for highly efficient cost-effective catalyst for hydrogen evolution by electric and solar energy conversion.

19.
ACS Appl Mater Interfaces ; 11(28): 25264-25270, 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31265219

RESUMO

Introducing anion vacancies on two-dimensional transition-metal dichalcogenides (TMDs) would significantly improve their catalytic activity. In this work, we proposed a solid-phase reduction (SPR) strategy to simultaneously achieve efficient exfoliation and controlled generation of chalcogen vacancies on TMDs. Consecutive sulfur vacancies were successfully created on the basal plane of the bulk MoS2 and WS2, and their interlamellar distances were distinctly expanded after the SPR treatment (about 16%), which can be conveniently exfoliated by only gentle shaking. The S-vacancy significantly increases the hydrogen-evolution reaction activity of the MoS2 and WS2 nanosheets, with overpotential of -238 and -241 mV at 10 mA cm-2, respectively. We anticipate that our SPR strategy will supply a general platform for the development of TMD-based electrocatalysts for industrial water splitting and hydrogen production in the near future.

20.
Front Neurosci ; 13: 627, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31275106

RESUMO

Deep learning has great potential for imaging classification by extracting low to high-level features. Our aim was to train a convolutional neural network (CNN) with single T2-weighted FLAIR sequence to classify different cognitive performances in patients with subcortical ischemic vascular disease (SIVD). In total, 217 patients with SIVD [including 52 with vascular dementia (VaD), 82 with vascular mild cognitive impairment (VaMCI), and 83 with non-cognitive impairment (NCI)] and 46 matched healthy controls (HCs) underwent MRI scans and neuropsychological assessments. 2D and 3D CNNs were trained to classify VaD, VaMCI, NCI, and HCs based on FLAIR data. For 3D-based model, the loss curves of the training set approached 0.017 after about 20 epochs, while the curves of the testing set maintained at about 0.114. The accuracy of training set and testing set reached 99.7 and 96.9% after about 30 and 35 epochs, respectively. However, the accuracy of the 2D-based model was only around 70%, which performed significantly worse than 3D-based model. This experiment suggests that deep learning is a powerful and convenient method to classify different cognitive performances in SIVD by extracting the shift and scale invariant features of neuroimaging data with single FLAIR sequence. 3D-CNN is superior to 2D-CNN which involves clinical evaluation with MRI multiplanar reformation or volume scanning.

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