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1.
Biomed Pharmacother ; 125: 109568, 2020 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-32058209

RESUMO

Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non-cancerous sample. The luciferase reporter gene assay reveals the relationship between LOXL1-AS1 and miR-18b-5p, miR-18b-5p and its target gene, Vacuolar ATPase Assembly Factor VMA21 (VMA21). Transfection of LOXL1-AS1 siRNA or miR-18b-5p mimics inhibits the growth and aggressive phenotypes of SKOV3 and OVCAR3 cell. Furthermore, miR-18b-5p suppresses ovarian carcinoma cell proliferation and metastasis by targeting VMA21 and LOXL1-AS1 regulates ovarian carcinoma cell growth and metastasis through sponging miR-18b-5p. These findings suggest that lncRNA LOXL1-AS1 promotes ovarian cancer cell growth, migratory and invasiveness via modulating miR-18b-5p/VMA21 axis.

2.
Onco Targets Ther ; 12: 8935-8945, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31806990

RESUMO

Background: The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer. Methods: The levels of miR-139-3p in ovarian cancer cells and tissues were detected using quantitative real-time-PCR (qRT-PCR) assay. The proliferation, colony formation, migration and invasion of ovarian cancer cell were determined, respectively. A luciferase reporter assay was used to confirm ELAV Like RNA Binding Protein 1 (ELAVL1) was a target gene of miR-139-3p. The expression of ELAVL1 was detected using Western blotting and immunofluorescence staining assay. The roles of miR-139-3p on the growth and metastasis of ovarian cancer cell in vivo were explored using transplanted tumor model and experimental lung metastasis model. Results: MiR-139-3p was down-regulated in ovarian cancer tissues and ovarian cancer cell lines (SK-OV-3, A2780 and OVCAR-3). Overexpression of miR-139-3p decreased the growth, colony formation, migration and invasiveness of SK-OV-3 and OVCAR-3 cells. Moreover, overexpression of miR-139-3p reduced the growth and lung metastasis of ovarian cancer cells in vivo. The luciferase reporter gene assay indicated that ELAVL1 was a target of miR-139-3p and its expression was negatively regulated by miR-139-3p. Furthermore, the expression of ELAVL1 was inversely correlated with miR-139-3p level in ovarian cancer tissue. Conclusion: Taken together, we demonstrated that miR-139-3p regulated ovarian cancer growth and metastasis by modulating the expression of ELAVL1.

3.
Z Naturforsch C J Biosci ; 74(9-10): 275-278, 2019 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-31490779

RESUMO

A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1-5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.


Assuntos
Anti-Infecciosos/química , Artemisia/química , Extratos Vegetais/química , Anti-Infecciosos/farmacologia , Bacillus cereus/efeitos dos fármacos , Extratos Vegetais/farmacologia , Staphylococcus aureus/efeitos dos fármacos , Triterpenos/química , Triterpenos/farmacologia , Yersinia enterocolitica/efeitos dos fármacos
4.
Front Genet ; 10: 474, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31191604

RESUMO

Genetic disease genes are considered a promising source of drug targets. Most diseases are caused by more than one pathogenic factor; thus, it is reasonable to consider that chemical agents targeting multiple disease genes are more likely to have desired activities. This is supported by a comprehensive analysis on the relationships between agent activity/druggability and target genetic characteristics. The therapeutic potential of agents increases steadily with increasing number of targeted disease genes, and can be further enhanced by strengthened genetic links between targets and diseases. By using the multi-label classification models for genetics-based drug activity prediction, we provide universal tools for prioritizing drug candidates. All of the documented data and the machine-learning prediction service are available at SCG-Drug (http://zhanglab.hzau.edu.cn/scgdrug).

5.
Asian Pac J Allergy Immunol ; 37(3): 147-153, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29981565

RESUMO

BACKGROUND: The worldwide prevalence of allergic diseases has increased during the last few decades, but it is not well known about the sensitization profiles of adult patients in Shanghai. OBJECTIVE: This study aimed to identify the prevalence and sex difference of allergen sensitization among adult with allergic diseases in Shanghai. METHODS: The sensitization profiles of 7,996 patients (18-60 yrs old) with allergic diseases at our center were retrospectively analyzed, based on the results of skin prick tests. The prevalence of various allergen, age and sex difference of allergen sensitization were investigated. RESULTS: The most common allergens were Dermatophagoides farinae (73.10%), Dermatophagoides pteronyssinus (72.21%) and Blomia tropicalis (53.10%), followed by Blattella germanica (31.18%), Periplaneta americana (27.75%), dog dander (24.96%), mixed molds (17.56%), and shrimp (17.02%). For the patients aged 18-30 yrs, mites and animal dander were most common allergen, whereas cockroaches and mixed molds for those aged over 40 yrs old. As for sex difference, males were more sensitive to Blomia tropicalis, cockroaches and mixed molds. Females were more sensitive to Dermatophagoides farinae and animal dander. CONCLUSIONS: The most common allergen in Shanghai are mites, cockroaches, and dog dander. There are sex and age difference on profiles of allergen sensitization.

6.
J Cancer Res Ther ; 14(Supplement): S1188-S1192, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30539869

RESUMO

Objective: To investigate the correlation between the expression of programmed death 1 (PD-1) and PD ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) and clinical parameters. Materials and Methods: The study comprised tumor sections from 45 HCC patients treated with curative resection, which were evaluated for PD-1 and PD-L1 protein expression by immunohistochemistry. Results: PD-1 and PD-L1 expression was increased in cancers compared to adjacent normal tissues, with a positive rate of 37.78% (17/45) and 62.22% (28/45), respectively, which was positively correlated with the tumor stage and lymph node metastasis, negatively with postoperative prognosis. PD-1 positivity was most frequently observed in stromal tumor-infiltrating lymphocytes. The number of PD-1 positive lymphocyte was correlated with PD-L1 positive expression. Conclusion: PD-L1 and PD-1 are overexpressed in HCC tissues. PD-L1 expression plays a critical role in the pathogenesis of human HCC, suggesting that it might be used as a new biomarker to predict the disease progression and prognosis.


Assuntos
Antígeno B7-H1/metabolismo , Biomarcadores Tumorais/metabolismo , Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Receptor de Morte Celular Programada 1/metabolismo , Adulto , Idoso , Carcinoma Hepatocelular/mortalidade , Carcinoma Hepatocelular/cirurgia , Progressão da Doença , Feminino , Seguimentos , Humanos , Fígado/patologia , Fígado/cirurgia , Neoplasias Hepáticas/mortalidade , Neoplasias Hepáticas/cirurgia , Linfonodos/patologia , Metástase Linfática/patologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Análise de Sobrevida
7.
Huan Jing Ke Xue ; 38(5): 1947-1956, 2017 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965100

RESUMO

A novel composite adsorbent (Ti-Zr-D201) for simultaneous removal of phosphate and fluoride from water was prepared by loading nanosized titanium and zirconium oxides on the anion exchange resin named D201. Combining with the characterization of the adsorbent, adsorption isotherm experiments, effect of solution pH experiments, competitive tests, kinetic experiments and fixed bed column adsorption experiments were performed to explore the adsorption performance and mechanism. The maximum adsorption capacity of Ti-Zr-D201 for phosphorus and fluorine was 34.9mg·g-1 and 35.1mg·g-1 respectively, when the pH value was 5.8 and the temperature was 308K. Adsorption behavior was spontaneous, and higher temperature was favorable for phosphorus and fluoride adsorption. The effect of pH on the adsorption of fluoride was more significant compared with the adsorption of phosphorus. SO42-, NO3- and Cl- were selected as the competitive ions for competition experiments, and the results indicated that Ti-Zr-D201 exhibited favorable sorption selectivity for phosphorus and fluoride compared with the host material D201. The fitting results of the internal diffusion model showed that there were two different adsorption stages before the adsorption equilibrium of Ti-Zr-D201. Column adsorption experiments showed that Ti-Zr-D201 had a stable structure, excellent dynamic adsorption performance, and could be recycled, which showed the potential of practical application.

8.
Huan Jing Ke Xue ; 38(5): 1972-1981, 2017 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965103

RESUMO

Phthalic acid esters have potential environmental risk due to their endocrine disrupting effect. The biodegradable and removal characteristics of 11 phthalicacidesters were studied. The results showed that dimethyl phthalate(DMP), dimethoxyethyl phthalate (BMEP), diethyl phthalate(DEP), dibutyl phthalate (DBP), diisobutyl phthalate(DIBP), dinamyl phthalate (DNPP), di-n-hexyl phthalate(DNHP)and bis (2-ethylhexyl) phthalate (DEHP) had ready biodegradability, dinonyl phthalate (DNP)and dicyclohexyl phthalate (DHP)could be biodegraded but did not pass the 10 d window-period, and only 43.5% of diphenyl phthalate (DPP) was biodegraded on 28d. The degradation curves of 11 PAEs all obeyed typical first-order kinetics in aerobic sludge kinetics test, with the correlation coefficient r2>0.96, the degradation rate constant was between 0.021-1.11 h-1, and the degradation half-life was between 0.625-32.7 h. In aerobic sludge simulation test, the removal rates of 10 PAEs were>80% at hydraulic detention time of 12h, except that DNPP was only 55%-70%. The removal rates of all PAEs reached 90% at hydraulic detention time of 24h. The relative high exposure in effluent for DMP, DEP, DIBP, DBP and DEHP was found by using GC/MS, with the residue concentrations of ND-44.0, ND-12.0, 60.4-594, 88.0-823 and 130-728 ng·L-1, respectively. The results from STP model prediction showed that the removal in STP was mainly contributed by biodegradation, but for DPP, DNP and DEHP, the absorption removal was also an important removal way.


Assuntos
Ésteres/química , Ácidos Ftálicos/química , Esgotos/química , Eliminação de Resíduos Líquidos , Aerobiose , Biodegradação Ambiental , Dibutilftalato , Cinética
9.
Huan Jing Ke Xue ; 37(1): 228-39, 2016 Jan 15.
Artigo em Chinês | MEDLINE | ID: mdl-27078962

RESUMO

Sewage treatment plant (STP) is a key transfer station for chemicals distributed into different environment compartment, and hence models of exposure prediction play a crucial role in the environmental risk assessment and pollution prevention of chemicals. A mass balance model namely Chinese Sewage treatment plant (C-STP(O)) was developed to predict the fate and exposure of chemicals in a conventional sewage treatment plant. The model was expressed as 9 mixed boxes by compartment of air, water, suspended solids, and settled solids. It was based on the minimum input data required on the notification in new chemicals, such as molecular weight, absorption coefficient, vapor pressure, water solubility, ready or inherent biodegradability. The environment conditions ( Temperature = 283 K, wind speed = 2 m x s(-1)) and the classic STP scenario parameters of China, especially the scenario parameters of water quality and sludge properties were adopted in C-STP( 0) model to reflect Chinese characteristics, these parameters were sewage flow of 35 000 m3 x d(-1), influent BOD5 of 0.15 g x L(-1), influent SS of 0.2 kg x m(-3), effluent SS of 0.02 kg x m(-3), BOD5 removal in aerator of 90% sludge density of 1.6 kg x L(3) and organic carbon content of 0.18-0.19. It adopted the fugacity express for mechanism of linear absorption, first-order degradation, Whitman two resistances. An overall interphase transfer constant which was the sum of surface volatilization and stripping was used to assess the volatilization in aerator. The most important and uncertain input value was the biodegradation rate constant, and determination of which required a tier test strategy from ready or inherent biodegradability data to simulate test in STP. An extrapolated criterion of US EPA to derive biodegradation rate constant using the results of ready and inherent biodegradability was compared with that of EU and was recommended. C-STP ( 0 ) was valid to predict the relative emission of volatilization, absorption, degradation and effluent, on ground of both successful simulation of the removal of 26 chemicals from references with an accuracy rate of 81% and consistency of prediction and test with absolute difference of 2.5%-6.3% for 5 phenols. In cases of prediction of three chemicals with different properties, 1,1, 2-trichloroethane, Naphthalene and DEHP, the predicted fate well satisfied the monitor data. The model is therefore believed to be a simple, robust and useful tool in fate study and exposure assessment of chemicals.


Assuntos
Modelos Químicos , Esgotos/química , Poluentes Químicos da Água/química , Purificação da Água/métodos , Biodegradação Ambiental , China , Volatilização , Águas Residuárias/química , Qualidade da Água
10.
Huan Jing Ke Xue ; 37(1): 240-6, 2016 Jan 15.
Artigo em Chinês | MEDLINE | ID: mdl-27078963

RESUMO

The removal rates of 4-nitroaniline, 4-isopropyl aniline and 2-chloro-4-nitroaniline under different hydraulic retention time (HRT) were tested by employing a simulation method of aerobic biochemical sewage treatment technology in this study. The results showed that when HRT was 6 h, 12 h, and 24 h, the removal rates of dissolved organic carbon (DOC) were 70.2%, 80.3% and 88.3%, the removal rates of 4-nitroaniline were 48%, 64.7% and 75%; and the removal rates of 4-isopropyl aniline were 66%, 76% and 91%, respectively. It was concluded that increasing HRT could promote the removal rates of DOC and aniline chemicals. In contrast, 2-chloro-4-nitroaniline was difficult to be removed. The removal rates were less than 20% under all tested conditions. The kinetics analysis showed that the biodegradation of 4-nitroaniline, 4-isopropyl aniline and 2-chloro-4-nitroaniline in aerobic activated sewage (3 g x L(-1)) accorded with the first order kinetics and the regression coefficients were > 0.95. The half-life time of biodegradation was 6.01 h, 16.16 h, 123.75 h, respectively. In general, functional groups such as isopropyl had a positive effect on the biodegradation of aniline chemicals, whereas substituents such as nitro group and chlorine atom had an inhibitory effect.


Assuntos
Compostos de Anilina/química , Esgotos/química , Eliminação de Resíduos Líquidos , Biodegradação Ambiental
11.
Int J Clin Exp Med ; 8(4): 6242-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26131232

RESUMO

Gefitinib was compared with pemetrexed as maintenance therapy in Patients with Advanced Glandular Non-small Cell Lung Cancer, mainly regarding clinical effect and side effect. A randomized trial of pemetrexed as study group (500 mg/m(2), dl) versus gefitinib as the control group [250 mg on night 1, 250 mg on morning 2 (every day)] was conducted in 188 patients, 94 cases in each group with a therapy cycle of 21 days. In addition, the study group was also treated with folic acid, vitB12 and dexamethasone. Therapeutic effects and adverse reactions of the two groups were compared. Patients of two groups completed four cycles of chemotherapy mostly, and there was no complete remission (CR) case. The median-cycle of chemotherapy was 2 for the study group, and partial response (PR), stable disease (SD), progressive disease (PD) were observed in 28 (29.8%), 34 (36.2%), 32 (34.0%) cases respectively. The median-cycle was 3 for the control group, PR, SD and PD were observed in 17 (18.1%), 23 (24.5%), 54 (57.4%) cases respectively. The effective rates were 29.8% and 18.1% for pemetrexed (28 cases) and gefitinib (17 cases) respectively (P > 0.05). However, there was a statistically significant difference in disease control rates between the 2 groups (65.0% vs 42.6%; P < 0.05). Adverse reactions occurred in two groups were mainly mild adverse reactions of 1-2 degree, without renal failure. The study group and control group had three and five cases of mild infection respectively, without statistically significant difference. There was no significant difference in the incidence rate of rash and alopecia between the two groups (P > 0.05). However, the number of cases with neutropenia, anemia, thrombocytopenia, gastrointestinal reactions and fatigue in the study group was lower than that of the control group, with a statistically significant difference (P < 0.05). Considering the disease control rate and the tolerance of patients with advanced NSCLC, pemetrexed is strongly recommended to be used in clinical.

12.
PLoS One ; 8(4): e62854, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23638155

RESUMO

OBJECTIVE: To investigate the levels of primary health care services for children and their changes in Zhejiang Province, China from 1998 to 2011. METHODS: The data were drawn from Zhejiang maternal and child health statistics collected under the supervision of the Health Bureau of Zhejiang Province. Primary health care coverage, hospital deliveries, low birth weight, postnatal visits, breastfeeding, underweight, early neonatal (<7 days) mortality, neonatal mortality, infant mortality and under-5 mortality were investigated. RESULTS: The coverage rates for children under 3 years old and children under 7 years old increased in the last 14 years. The hospital delivery rate was high during the study period, and the overall difference narrowed. There was a significant difference (P<0.001) between the prevalence of low birth weight in 1998 (2.03%) and the prevalence in 2011 (2.71%). The increase in low birth weight was more significant in urban areas than in rural areas. The postnatal visit rate increased from 95.00% to 98.45% with a significant difference (P<0.001). The breastfeeding rate was the highest in 2004 at 74.79% and lowest in 2008 at 53.86%. The prevalence of underweight in children under 5 years old decreased from 1.63% to 0.65%, and the prevalence was higher in rural areas. The early neonatal, neonatal, infant and under-5 mortality rates decreased from 6.66‰, 8.67‰, 11.99‰ and 15.28‰ to 1.69‰, 2.36‰, 3.89‰ and 5.42‰, respectively (P<0.001). The mortality rates in rural areas were slightly higher than those in urban areas each year, and the mortality rates were lower in Ningbo, Wenzhou, and Jiaxing regions and higher in Quzhou and Lishui regions. CONCLUSION: Primary health care services for children in Zhejiang Province improved from 1998 to 2011. Continued high rates of low birth weight in urban areas and mortality in rural areas may be addressed with improvements in health awareness and medical technology.


Assuntos
Serviços de Saúde da Criança/estatística & dados numéricos , Mortalidade , Aleitamento Materno/tendências , Criança , Serviços de Saúde da Criança/tendências , Pré-Escolar , China/epidemiologia , Humanos , Lactente , Recém-Nascido , Mortalidade/tendências , Atenção Primária à Saúde/estatística & dados numéricos , Atenção Primária à Saúde/tendências , Magreza/epidemiologia
13.
Transl Pediatr ; 2(1): 34-9, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26835282

RESUMO

OBJECTIVE: By analyzing the under 5 mortality rate (U5MR) and its contributors in Zhejiang Province of China from 2000 to 2009, we tried to understand the trend of U5MR change in Zhejiang Province and thus propose strategies to reduce child mortality. METHODS: Thirty cities/counties/districts from Zhejiang Province were selected using stratified cluster sampling approach. Children under five years in these areas were enrolled as the subjects. The U5MR and its contributors were analyzed in terms of age, migration status of mothers, and other indicators using classic descriptive methods and Chi square test. RESULTS: The U5MR in Zhejiang Province showed a declining trend from 14.83‰ in 2000 to 9.49‰ in 2009. In 2009, the U5MR was significantly higher in the rural areas than in the urban areas (9.14‰ vs.6.50‰, P<0.01) and among floating populations than among local residents (12.12‰ vs. 6.42‰, P<0.01). Preterm birth/low birth weight was the leading cause of U5MR in 2009. More specifically, preterm birth/low birth weight, congenital heart disease, and birth asphyxia were the top three causes of deaths among infants (<1 year), while drowning, traffic accidents, and accidental falls were the leading causes of deaths among children (1-4 years). CONCLUSION: The U5MR in Zhejiang Province in 2009 differed between urban areas and rural areas and between floating populations and local residents. The main causes of death differ between infants and young children. Prevention of preterm birth/low birth weight and congenital anomalies will reduce infant death, while the main intervention for young children is to avoid accidental injuries.

14.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 41(5): 491-7, 2012 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-23086640

RESUMO

OBJECTIVE: To investigate the effect of histone deacetylase inhibitor suberic bishydroxamate (SBHA) on human acute myeloid leukemia (AML) cell lines. METHODS: AML U937, KG-1 and Kasumi-1 cells were treated with SBHA. Cell growth was measured by MTT assay. Apoptosis was determined using flow cytometry. Activation of Caspase pathway and expression of apoptosis regulator proteins were detected by Western blot. RESULTS: SBHA significantly induced growth arrest and apoptosis in U937, KG-1 and Kasumi-1 cells. Enhanced apoptosis was observed in SHBA group evidenced by strong activation of Caspase-9, Caspase-8 and Caspase-3. SHBA treatment resulted in down-regulation of anti-apoptotic protein Bcl-2 and Bcl-xl expression; down-regulated expression of antiapoptotic proteins survivin, XIAP and cIAP was also detected after SBHA treatment. CONCLUSION: SBHA can effectively kill AML cells by inhibiting cell growth and inducing apoptosis, which is associated with the activation of Caspase pathway and regulation of apoptotic related proteins.


Assuntos
Inibidores de Histona Desacetilases/farmacologia , Ácidos Hidroxâmicos/farmacologia , Leucemia Mieloide Aguda/patologia , Apoptose/efeitos dos fármacos , Proteínas Reguladoras de Apoptose/metabolismo , Caspases/metabolismo , Linhagem Celular Tumoral , Humanos , Leucemia Mieloide Aguda/metabolismo
16.
Zhongguo Dang Dai Er Ke Za Zhi ; 13(7): 561-4, 2011 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-21752323

RESUMO

OBJECTIVE: To study the under-five mortality rate and the causes of death in Zhejiang Province between 2000 and 2009 in order to provide a basis for reducing the mortality rate in the region. METHODS: By stratified random cluster sampling, all the children under 5 years old from 30 sampling areas of Zhejiang Province between 2000 and 2009 were enrolled. The under-five mortality rate and the leading causes of death were investigated by descriptive analysis and Chi-square test. RESULTS: The under-five mortality rate demonstrated a decreased trend in Zhejiang Province between 2000 and 2009, with the under-five mortality rate of 14.83‰ in 2000 compared to 9.49‰ in 2009. In 2009, the under-five mortality rate in rural regions was significantly higher than that in urban regions (9.14‰ vs 6.50‰; P<0.01). Compared with the resident population, there were an increased under-five mortality rate in floating population (12.12‰ vs 6.42‰; P<0.01). Preterm delivery/low birth weight was the top death cause in children under 5 years old. The top three causes of death in infants less than 1 year old were preterm delivery/low birth weight, congenital heart disease and birth asphyxia compared to drowning, traffic accident and falling in children aged 1-4 years. CONCLUSIONS: There are differences in the under-five mortality rate between rural and urban children as well as between the floating and resident population in 2009. The leading causes of death in different age groups are different. It is essential to reduce the mortality rate by preventing preterm delivery, low birth weight and congenital malformations to infants and preventing accidental injuries to children aged 1-4 years.


Assuntos
Mortalidade da Criança , Mortalidade Infantil , Causas de Morte , Pré-Escolar , China/epidemiologia , Humanos , Lactente , Recém-Nascido , Fatores de Tempo
17.
J Ultrasound Med ; 30(7): 895-8, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21705721

RESUMO

OBJECTIVES: The purposes of this study were to determine thyroid volumes in healthy Chinese infants aged 0 to 12 months and to provide reference data for normal thyroid growth. METHODS: A total of 408 healthy infants (229 male and 179 female) were enrolled in the study. The length, breadth, and depth of the thyroid gland were measured with sonography. The volume of each lobe was calculated by the correct ellipsoid formula (volume = length × breadth × depth × 0.479). RESULTS: All of the infants' thyroids showed a normal uniform echo texture on sonography. The thyroid volume increased with age (r = 0.519; P < .001). Moreover, positive associations were noted between thyroid volume and height and weight (r = 0.517; P < . 001; r = 0.499; P < .001, respectively). No significant differences based on sex were found (t = 1.784; P = .075). CONCLUSIONS: The thyroid volumes in these healthy Chinese infants varied from those reported in the published literature on healthy European infants. It is important to establish local reference ranges for thyroid volumes in healthy infants.


Assuntos
Glândula Tireoide/diagnóstico por imagem , Análise de Variância , China , Feminino , Humanos , Hipotireoidismo/diagnóstico por imagem , Lactente , Recém-Nascido , Masculino , Valores de Referência , Glândula Tireoide/crescimento & desenvolvimento , Ultrassonografia
18.
Zhongguo Zhen Jiu ; 30(11): 904-6, 2010 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-21246845

RESUMO

OBJECTIVE: To compare the therapeutic effects between acupuncture based on syndrome differentiation and analgesic on abdominal postoperative pain. METHODS: One hundred cases of abdominal postoperative pain were randomly divided into two groups, 50 cases in each one. In acupuncture group, the treatment was applied according to meridian differentiation and point selection on the affected meridian. Ashi points near to the incision as the main points and those closely connected with Zangfu functions were selected, such as Yanglingquan (GB 34), Taichong (LR 3) and Zusanli (ST 36), etc. In medication group, muscular injection of Bucinnazine was administered. The severity of pain was evaluated with Visual Analogue Scale (VAS) before and after treatment. RESULTS: The remarkably effective rate in acupuncture group was 60.0% (30/50), which was markedly better than that 28.0% (14/50) in medication group (P < 0.01). VAS scores in 30 min and 4 h after treatment as well as 24 h after operation in two groups were all reduced remarkably as compared with those before treatment (all P < 0.01), indicating the satisfactory analgesia in treatment. VAS scores in acupuncture group were lower apparently than those in medication group in 30 min and 4 h after treatment (P < 0.01,P < 0.05). CONCLUSION: Acupuncture has quick analgesia in treatment of abdominal postoperative pain, which is superior to muscular injection of Bucinnazine because of its advantages of long-term and significant efficacy.


Assuntos
Abdome/cirurgia , Analgesia por Acupuntura , Terapia por Acupuntura , Dor Pós-Operatória/terapia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Adulto Jovem
19.
Acta Crystallogr Sect E Struct Rep Online ; 66(Pt 2): o410, 2010 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-21579829

RESUMO

The title compound, C(18)H(17)N(3)S(2), was synthesized by the reaction of 5-(3,5-dimethyl-phen-yl)-1,3,4-thia-diazol-2-amine and 4-(methyl-sulfan-yl)benzaldehyde. An intra-molecular C-H⋯S hydrogen bond results in the formation of a planar (r.m.s. deviation = 0.003 Å) five-membered ring. In the crystal structure, inter-molecular C-H⋯N hydrogen bonds link the mol-ecules to form layers parallel to (011).

20.
Zhonghua Er Ke Za Zhi ; 47(1): 18-22, 2009 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-19573375

RESUMO

OBJECTIVE: The retrospective study was carried out to investigate the nation-wide neonatal screening program in the past 22 years in China. This study aimed to summarize the experience, analyze the questions and concerns in the screening program. METHODS: All data on the national neonatal screening in the past 22 years were from National Center for Clinical Laboratory. Study items included the development and mode of the program, screening method adopted as well as the clinical records of prevalence, treatment and follow-up etc. RESULTS: Neonatal screening has become universal since 1985 in China. There were three modes of screening and treatment. From 1985 to 2006, a total of 13,229,242 newborns were screened for congenital hypothyroidism (CH) and 6505 were diagnosed as CH at a prevalence of 49.2/100,000; a total of 13,666,750 newborns were screened for phenylketonuria (PKU), and 1,170 were diagnosed as PKU at a prevalence of 8.6/100,000. The prevalence of CH increased year by year and the western regions in China had a much higher prevalence. The prevalence of PKU was relatively more steady than that of CH in China. CONCLUSIONS: Neonatal screening is of paramount importance in preventing mental retardation and developmental delay after CH and PKU. It is necessary to attach more importance to increase the rate of coverage, screening and treatment, as well as social awareness of neonatal screening. It is important to focus on establishment of new screening techniques so as to improve the level of child health care in China.


Assuntos
Hipotireoidismo Congênito/epidemiologia , Fenilcetonúrias/epidemiologia , China/epidemiologia , Humanos , Recém-Nascido , Triagem Neonatal , Prevalência , Estudos Retrospectivos
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