Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 115
Filtrar
1.
ACS Omega ; 7(42): 37629-37639, 2022 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-36312378

RESUMO

Porous double-shelled ceramic hollow spheres (PDSs) have attracted extensive attention due to their high specific surface areas and multifunctional designs. When used in wastewater treatment, millimeter or sub-millimeter spheres can be quickly separated from water by commercial sieves. However, the simple, scalable, and low-cost preparation of sub-millimeter PDSs in the solid phase remains a challenge. Herein, porous PDSs were facilely fabricated via a spheronization process utilizing pseudoboehmite powders and wet gelatin spheres as templates, which broke through the difficulty of preparing PDSs by one-step solid-state synthesis. Treating pseudoboehmite powder with nitric acid can improve the compressive strength of the PDSs. By controlling the rolling time and gelatin concentration of gelatin microspheres, the integrity, shell thickness, and double-shelled spacing of the gelatin microspheres were tuned. When the rolling time was 8-12 min, and the gelatin concentration in gelatin spheres was 250 g/L, and PDSs with a complete double-shelled structure, good mechanical property, and high specific surface area (327.5-509.6 m2/g) were obtained at 600 °C. The adsorption capacities of the PDSs for 100 mg/L Congo red solution (70.7 mg/g) were larger than those of single-shelled hollow spheres (49 mg/g), and larger diameters (608-862 µm) of the PDSs allow them to be rapidly separated from solution by a commercial sieve. This paper provides a facile and scalable method for the preparation of sub-millimeter PDSs and demonstrates their excellent adsorption capacity for Congo red solution.

2.
Chem Commun (Camb) ; 58(90): 12518-12527, 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36285817

RESUMO

The liver is the largest detoxification organ in the human body, with an array of functions that help support metabolism, immunity, digestion, and vitamin storage, among other functions, and maintains the health and stability of the internal environment. Liver injury causes the concentration fluctuation of related biomarkers, small molecules, and enzymes, and in turn, the structure and function of the liver are changed by those alterations. With the principles of early detection, early diagnosis, and early treatment, it is crucial to design and synthesise a tool for detecting related biomarkers during liver damage and lesion, among which fluorescent probes have attracted attention in recent years. In the course of liver diseases, the asialoglycoprotein receptors (ASGPR) are overexpressed on the hepatoma cells, which can specifically recognize the galactose variant. Several galactose-based fluorescent probes have been developed to target hepatocytes via specific receptor-mediated endocytosis and release fluorophores after reacting with specific small molecules and enzyme biomarkers. The change in fluorescence intensity reflects the level of substances, such as reactive oxygen species, reactive nitrogen species, reactive sulfur species, enzymes or metal ions, etc. The application of fluorescent probes in vivo can aid in monitoring the dynamic changes of endogenous and exogenous biomarkers. This Highlight provides an update on the progress, limitations, and prospects of galactose-based fluorescent probes applications in the early diagnosis of liver diseases.


Assuntos
Corantes Fluorescentes , Hepatopatias , Humanos , Corantes Fluorescentes/química , Galactose/metabolismo , Espécies Reativas de Nitrogênio , Hepatopatias/diagnóstico , Biomarcadores
3.
Dis Markers ; 2022: 7826393, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36246561

RESUMO

Background: The epithelial mesenchymal transition (EMT) gene has been shown to be significantly associated with the prognosis of solid tumors; however, there is a lack of models for the EMT gene to predict the prognosis of AML patients. Methods: First, we downloaded clinical data and raw transcriptome sequencing data from the TCGA database of acute myeloid leukemia (AML) patients. All currently confirmed EMT-related genes were obtained from the dbEMT 2.0 database, and 30% of the TCGA data were randomly selected as the test set. Univariate Cox regression analysis, random forest, and lasso regression were used to optimize the number of genes for model construction, and multivariate Cox regression was used for model construction. Area under the ROC curve was used to assess the efficacy of the model application, and the internal validation set was used to assess the stability of the model. Results: A total of 173 AML samples were downloaded, and a total of 1184 EMT-related genes were downloaded. The results of univariate batch Cox regression analysis suggested that 212 genes were associated with patient prognosis, random forest and lasso regression yielded 18 and 8 prognosis-related EMT genes, respectively, and the results of multifactorial COX regression model suggested that 5 genes, CBR1, HS3ST3B1, LIMA1, MIR573, and PTP4A3, were considered as independent risk factors affecting patient prognosis. The model ROC results suggested that the area under the curve was 0.868 and the internal validation results showed that the area under the curve was 0.815. Conclusion: During this study, we constructed a signature model of five EMT-related genes to predict overall survival in patients with AML; it will provide a useful tool for clinical decision making.


Assuntos
Leucemia Mieloide Aguda , MicroRNAs , Proteínas do Citoesqueleto/genética , Transição Epitelial-Mesenquimal/genética , Perfilação da Expressão Gênica , Humanos , Leucemia Mieloide Aguda/genética , MicroRNAs/genética , Proteínas de Neoplasias/genética , Prognóstico , Proteínas Tirosina Fosfatases/genética , Transcriptoma
4.
Front Plant Sci ; 13: 968719, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36247600

RESUMO

Karst ecosystems represent a typical heterogeneous habitat, and it is ubiquitous with varying interactive patches of rock and soil associated with differential weathering patterns of carbonate rocks. Arbuscular mycorrhizae fungi (AMF) play an important role in regulating plant growth and nutrition in heterogeneous karst habitats. However, it remains unclear how AMF affects the growth and nutrition of plants in heterogeneous karst soil with varying patches and weathering gravel. A heterogeneous experiment with Bidens pilosa L. was conducted in a grid microcosm through patching karst soil with different gravel contents. The experimental treatments included the AMF treatments inoculated with (M+) or without (M-) fungus Glomus etunicatum; the substrate patchiness treatments involved different sizes of the homogeneous patch (Homo), the heterogeneous large patch (Hetl), and the heterogeneous small patch (Hets); the substrate gravel treatments in the inner patch involved the free gravel (FG), the low gravel (LG) 20% in 80% soil, and the high gravel (HG) 40% in 60% soil. Plant traits related to growth and nutrients were analyzed by comparing substrate gravel content and patch size. The results showed that AMF was more beneficial in increasing the aboveground biomass of B. pilosa under the LG and HG substrates with a higher root mycorrhizal colonization rate than under the FG substrate with a lower root mycorrhizal colonization rate. AMF enhanced higher growth and nutrients for B. pilosa under the LG and HG substrates than under the FG substrate and under the Hets than under the Hetl. Moreover, AMF alleviated the limited supply of N for B. pilosa under all heterogeneous treatments. Furthermore, the response ratio LnRR of B. pilosa presented that the substrate gravel promoted the highest growth, N and P absorption than the substrate patchiness with M+ treatment, and the gravel content had a more effect on plant growth and nutrition as compared to the patch size. Overall, this study suggests that plant growth and nutrition regulated by AMF mainly depend on the substrate gravel content rather than the spatial patchiness in the heterogeneous karst habitat.

5.
Nat Commun ; 13(1): 5330, 2022 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-36088353

RESUMO

Water-in-salt electrolytes are an appealing option for future electrochemical energy storage devices due to their safety and low toxicity. However, the physicochemical interactions occurring at the interface between the electrode and the water-in-salt electrolyte are not yet fully understood. Here, via in situ Raman spectroscopy and molecular dynamics simulations, we investigate the electrical double-layer structure occurring at the interface between a water-in-salt electrolyte and an Au(111) electrode. We demonstrate that most interfacial water molecules are bound with lithium ions and have zero, one, or two hydrogen bonds to feature three hydroxyl stretching bands. Moreover, the accumulation of lithium ions on the electrode surface at large negative polarizations reduces the interfacial field to induce an unusual "hydrogen-up" structure of interfacial water and blue shift of the hydroxyl stretching frequencies. These physicochemical behaviours are quantitatively different from aqueous electrolyte solutions with lower concentrations. This atomistic understanding of the double-layer structure provides key insights for designing future aqueous electrolytes for electrochemical energy storage devices.

6.
Plant Divers ; 44(4): 389-405, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35967252

RESUMO

Previous studies recognized three major lineages of the family Costaceae: a South American clade, an Asian clade and a Costus clade. However, the genus Hellenia within the Asian clade has been shown to be non-monophyletic and its morphology has not been studied carefully. Therefore, the complete plastid genomes of Hellenia species were obtained and the monophyly of Hellenia was tested through four different datasets in this study. Plastid phylogenomic analyses of Costaceae revealed that Hellenia is strongly supported as paraphyletic. Two major clades are recovered, namely the Hellenia s.s. subclade and the Parahellenia subclade. Phylogenetic analyses based on an enlarged taxon sampling of the Asian clade using a two chloroplast markers dataset (trnK intron and trnL-F spacer) confirmed the paraphyly of Hellenia. Meanwhile, morphological analyses suggested that members of the Parahellenia subclade differ from the remaining Hellenia species in many characters including inflorescences, bracts, stigma, axillary buds, floral tubes and labellum. According to the present molecular and morphological evidence, the latter subclade is recognized as a new genus, Parahellenia. Two new species are described, four new combinations are made, and identification keys are also provided.

7.
J Chem Phys ; 157(7): 074101, 2022 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-35987599

RESUMO

When a physical system is driven away from equilibrium, the statistical distribution of its dynamical trajectories informs many of its physical properties. Characterizing the nature of the distribution of dynamical observables, such as a current or entropy production rate, has become a central problem in nonequilibrium statistical mechanics. Asymptotically, for a broad class of observables, the distribution of a given observable satisfies a large deviation principle when the dynamics is Markovian, meaning that fluctuations can be characterized in the long-time limit by computing a scaled cumulant generating function. Calculating this function is not tractable analytically (nor often numerically) for complex, interacting systems, so the development of robust numerical techniques to carry out this computation is needed to probe the properties of nonequilibrium materials. Here, we describe an algorithm that recasts this task as an optimal control problem that can be solved variationally. We solve for optimal control forces using neural network ansatz that are tailored to the physical systems to which the forces are applied. We demonstrate that this approach leads to transferable and accurate solutions in two systems featuring large numbers of interacting particles.


Assuntos
Redes Neurais de Computação , Física , Algoritmos , Entropia , Fatores de Tempo
8.
ACS Appl Mater Interfaces ; 14(28): 31911-31919, 2022 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-35796315

RESUMO

The quality of perovskite films plays a crucial role in the performance of the corresponding devices. However, the commonly employed perovskite polycrystalline films often contain a high density of defects created during film production and cell operation, including unsaturated coordinated Pb2+ and Pb0, which can act as nonradiative recombination centers, thus reducing open-circuit voltage. Effectively eliminating both kinds of defects is an important subject of research to improve the power conversion efficiency (PCE). Here, we employ hydrogen octylphosphonate potassium (KHOP) as a multifunctional additive to passivate defects. The molecule is introduced into perovskite precursor solution to regulate the perovskite film growth process by coordinating with Pb, which can not only passivate the Pb2+ defect but also effectively inhibit the production of Pb0; at the same time, the presence of K+ reduces device hysteresis by inhibiting I- migration and finally realizes double passivation of Pb2+ and I--based defects. Moreover, the moderate hydrophobic alkyl chain in the molecule improves the moisture stability. Ultimately, the optimal efficiency can reach 22.21%.

9.
Front Oncol ; 12: 883301, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35719990

RESUMO

Background: The long non-coding RNA (lncRNA)-mRNA regulation network plays an important role in the development of diffuse large B-cell lymphoma (DLBCL). This study uses bioinformatics to find an innovative regulation axis in DLBCL that will provide a positive reference for defining the mechanism of disease progression. Methods: Batch Cox regression was used to screen prognosis-related lncRNAs, and a random forest model was used to identify hub lncRNA. The clinical value of the lncRNA was evaluated and Spearman correlation analysis was used to predict the candidate target genes. Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were used to define the biological function of the lncRNA. A batch Cox regression model, expression validation, and Spearman correlation analysis were used to select the best downstream target genes. The expression and prognostic value validation of this gene was conducted using public data. Gene Set Enrichment Analysis (GSEA) was performed to explore potential mechanisms for this gene in DLBCL. Results: LINC00654 was identified as the hub lncRNA and 1443 mRNAs were selected as downstream target genes of the lncRNA. The target genes were enriched in the regulation of GTPase and Notch signaling pathways. After validation, the ninein-like (NINL) gene was selected as the potential target of LINC00654 and the LINC00654-NINL axis was constructed. Patients with better responses to therapy were shown to have high NINL gene expression (p-value = 0.036). NINL also had high expression in the DB cell line and low expression in the OCILY3 cell line. Survival analysis showed that high NINL expression was a risk factor for overall survival (OS) and disease-specific survival (DSS) within older patients and those with advanced-stage cancer. GSEA results showed that NINL may be involved in neutrophil-mediated immunity and NF-κB signaling. Conclusion: This study identified a novel LncRNA00654-NINL regulatory axis in DLBCL, which could provide a favorable reference for exploring the possible mechanisms of disease progression.

10.
Front Genet ; 13: 874673, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35547247

RESUMO

Background: The role of long-chain noncoding RNA (lncRNA) in genomic instability has been demonstrated to be increasingly importance. Therefore, in this study, lncRNAs associated with genomic instability were identified and kidney renal papillary cell carcinoma (KIRP)-associated predictive features were analysed to classify high-risk patients and improve individualised treatment. Methods: The training (n = 142) and test (n = 144) sets were created using raw RNA-seq and patient's clinical data of KIRP obtained from The Cancer Genome Atlas (TCGA).There are 27 long-chain noncoding RNAs (lncRNAs) that are connected with genomic instability, these lncRNAs were identified using the 'limma' R package based on the numbers of somatic mutations and lncRNA expression profiles acquired from KIRP TCGA cohort. Furthermore, Cox regression analysis was carried out to develop a genome instability-derived lncRNA-based gene signature (GILncSig), whose prognostic value was confirmed in the test cohort as well as across the entire KIRP TCGA dataset. Results: A GILncSig derived from three lncRNAs (BOLA3-AS1, AC004870, and LINC00839), which were related with poor KIRP survival, was identified, which was split up into high- and low-risk groups. Additionally, the GILncSig was found to be an independent prognostic predictive index in KIRP using univariate and multivariate Cox analysis. Furthermore, the prognostic significance and characteristics of GilncSig were confirmed in the training test and TCGA sets. GilncSig also showed better predictive performance than other prognostic lncRNA features. Conclusion: The function of lncRNAs in genomic instability and the genetic diversity of KIRP were elucidated in this work. Moreover, three lncRNAs were screened for prediction of the outcome of KIRP survival and novel insights into identifying cancer biomarkers related to genomic instability were discussed.

11.
Front Chem ; 10: 851264, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35392420

RESUMO

Solid-state electrolyte (SSE), as the core component of solid-state batteries, plays a critical role in the performance of the batteries. Currently, the development of SSE is still hindered by its high price, low ionic conductivity, and poor interface stability. In this work, we report the tailored synthesis of a high ionic conductive and low cost sulfide SSE for all-solid-state lithium batteries. The Li10.35Si1.35P1.65S12 with favorable tetragonal structure was synthesis by increasing the concentration of Si4+, which shows an ionic conductivity of 4.28 × 10-3 S cm-1 and a wide electrochemical stability window of up to 5 V. By further modifying the composition of the electrolyte via ionic doping, the ionic conductivity of Li10.35Si1.35P1.65S12 can be further enhanced. Among them, the 1% Co4+-doped Li10.35Si1.35P1.65S12 shows the highest ionic conductivity of 6.91 × 10-3 S cm-1, 40% higher than the undoped one. This can be attributed to the broadened MS4 - tetrahedrons and increased Li+ concentration. As a demonstration, an all-solid-state Li metal battery was assembled using TiS2 as the cathode and 1% Co4+-doped Li10.35Si1.35P1.65S12 as the electrolyte, showing capacity retention of 72% at the 110th cycle. This strategy is simple and can be easily extended for the construction of other high-performance sulfide SSEs.

12.
Phys Rev E ; 105(2-1): 024115, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35291069

RESUMO

Sampling the collective, dynamical fluctuations that lead to nonequilibrium pattern formation requires probing rare regions of trajectory space. Recent approaches to this problem, based on importance sampling, cloning, and spectral approximations, have yielded significant insight into nonequilibrium systems but tend to scale poorly with the size of the system, especially near dynamical phase transitions. Here we propose a machine learning algorithm that samples rare trajectories and estimates the associated large deviation functions using a many-body control force by leveraging the flexible function representation provided by deep neural networks, importance sampling in trajectory space, and stochastic optimal control theory. We show that this approach scales to hundreds of interacting particles and remains robust at dynamical phase transitions.

13.
Faraday Discuss ; 233(0): 190-205, 2022 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-34889342

RESUMO

Copper is the most widely used substrate for Li deposition and dissolution in lithium metal anodes, which is complicated by the formation of solid electrolyte interphases (SEIs), whose physical and chemical properties can affect Li deposition and dissolution significantly. However, initial Li nucleation and growth on bare Cu creates Li nuclei that only partially cover the Cu surface so that SEI formation could proceed not only on Li nuclei but also on the bare region of the Cu surface with different kinetics, which may affect the follow-up processes distinctively. In this paper, we employ in situ atomic force microscopy (AFM), together with X-ray photoelectron spectroscopy (XPS), to investigate how SEIs formed on a Cu surface, without Li participation, and on the surface of growing Li nuclei, with Li participation, affect the components and structures of the SEIs, and how the formation sequence of the two kinds of SEIs, along with Li deposition, affect subsequent dissolution and re-deposition processes in a pyrrolidinium-based ionic liquid electrolyte containing a small amount of water. Nanoscale in situ AFM observations show that sphere-like Li deposits may have differently conditioned SEI-shells, depending on whether Li nucleation is preceded by the formation of the SEI on Cu. Models of integrated-SEI shells and segmented-SEI shells are proposed to describe SEI shells formed on Li nuclei and SEI shells sequentially formed on Cu and then on Li nuclei, respectively. "Top-dissolution" is observed for both types of shelled Li deposits, but the integrated-SEI shells only show wrinkles, which can be recovered upon Li re-deposition, while the segmented-SEI shells are apparently top-opened due to mechanical stresses introduced at the junctions of the top regions and become "dead" SEIs, which forces subsequent Li nucleation and growth in the interstice of the dead SEIs. Our work provides insights into the impact mechanism of SEIs on the initial stage Li deposition and dissolution on foreign substrates, revealing that SEIs could be more influential on Li dissolution and that the spatial integration of SEI shells on Li deposits is important to improving the reversibility of deposition and dissolution cycling.

14.
Bioengineered ; 12(2): 12420-12430, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34781814

RESUMO

Oral squamous cell carcinoma (OSCC) is the most common oral cancer, with an increasing worldwide incidence and a worsening prognosis. Emerging evidence confirms that circular RNAs (circRNAs) play a critical role in tumor progression via sponging miRNAs. A previous study substantiated the function of circANKS1B in several cancers. However, its role in OSCC remains unclear. This study revealed the high expression of circANKS1B in OSCC tissues and cells. Moreover, the expression level of circANKS1B was highly positively correlated with the expression of transforming growth factor-beta1 (TGF-ß1) in OSCC tissues. Additionally, overexpression of circANKS1B enhanced the protein expression of TGF-ß1 in OSCC cells, while its inhibition reduced TGF-ß1 protein levels. Noticeably, the loss-function of circANKS1B restrained OSCC cell invasion, migration, and epithelial to mesenchymal transition (EMT) by decreasing N-cadherin expression and enhancing E-cadherin expression. Furthermore, the knockdown of circANKS1B sensitized OSCC cells to cisplatin by suppressing cell viability and increasing cell apoptosis and caspase-3 activity. Mechanically, bioinformation software (circinteractome and starBase 3.0) and dual-luciferase reporter assays corroborated that circANKS1B could sponge miR-515-5p. Moreover, miR-515-5p could directly target TGF-ß1 to suppress its expression. Importantly, inhibition of miR-515-5p or supplementation with TGF-ß1 overturned the effects of circANKS1B knockdown on cell invasion, migration, and cisplatin resistance. Thus, these findings highlight that circANKS1B might act as an oncogenic gene to facilitate the metastatic potential and cisplatin resistance in OSCC by sponging miR-515-5p to regulate TGF-ß1. Collectively, circANKS1B may be a promising target for therapy and overcoming chemoresistance in OSCC.


Assuntos
Carcinoma de Células Escamosas/genética , Resistencia a Medicamentos Antineoplásicos/genética , Peptídeos e Proteínas de Sinalização Intracelular/genética , MicroRNAs/genética , Neoplasias Bucais/genética , RNA Circular/genética , Fator de Crescimento Transformador beta1/genética , Adulto , Idoso , Apoptose/genética , Carcinoma de Células Escamosas/tratamento farmacológico , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células/genética , Cisplatino/farmacologia , Transição Epitelial-Mesenquimal/genética , Feminino , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/tratamento farmacológico , Prognóstico
15.
Inorg Chem ; 60(23): 17635-17640, 2021 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-34747595

RESUMO

Catalytic chemical degradations and many other methodologies have been explored for the removal and/or degradation of organophosphorus agents (OPs) that are often used as pesticides, nerve agents, and plasticizers. To explore more efficient and recyclable catalysts for the removal and/or degradation of OPs, we fabricate the composites of cobalt nanoparticles and three-dimensional nitrogen-doped graphene (Co/3DNG). We demonstrate that OPs can be hydrolyzed efficiently at ambient temperature by the Co/3DNG. Because of the unique structural and chemical properties of the supporting matrix 3DNG and active species Co-N, the catalytic activities of Co/3DNG composites are much higher than those of bare 3DNG, Co nanoparticles, or the Co nanoparticles physically mixed with 3DNG. We conclude that in the Co/3DNG composites, the interaction between 3DNG and Co stabilizes and distributes well the Co nanoparticles and affords the active catalytic species Co-N.

16.
Ann Clin Lab Sci ; 51(5): 726-729, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34686517

RESUMO

OBJECTIVE: Severe aplastic anemia (SAA) is a fatal bone marrow failure disease. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a matched sibling donor is the first-line treatment for older SAA patients. However, the number of CD34+ cells collected from a matched donor is often lower than expected. To overcome the problem, this study was conducted to combine a matched sibling donor with an unrelated cord blood transplantation for the treatment of a patient with SAA. CASE REPORT: A 45-year-old male patient with SAA was treated with a sibling-matched allo-HSCT. Due to the low amount of donor CD34+ cells, an unrelated umbilical cord blood stem cell transplantation (UCBT) with 9/10 HLA matching was subsequently carried out. Successful hematopoietic reconstitution was achieved by the dual transplantation. Unexpectedly, beginning in the fourth month after transplantation, the sibling donor chimerism was transformed to a stable and complete UCB source. CONCLUSION: This study provides evidence that UCB-derived HSCs have a higher capacity for hematopoietic reconstitution, suggesting that UCB plus an HLA-matched sibling donor is a good alternative for older patients with SAA.


Assuntos
Anemia Aplástica/terapia , Transplante de Medula Óssea/métodos , Transplante de Células-Tronco de Sangue do Cordão Umbilical/métodos , Sangue Fetal/citologia , Quimerismo , Humanos , Masculino , Pessoa de Meia-Idade , Irmãos , Transplante Homólogo , Doadores não Relacionados
17.
Dalton Trans ; 50(40): 14296-14302, 2021 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-34554175

RESUMO

Lithium metal batteries (LMBs) have attracted extensive attention for their ultrahigh energy density. However, the uncontrollable growth of Li-dendrites results in poor cyclability and potential safety risks, thus preventing their practical application. Herein, a flexible and cost-effective aqueous polyethylene oxide (PEO)-based solid-state electrolyte is prepared, which enables uniform and dendrite-free Li deposition by introducing Cs+ with an electrostatic shielding mechanism at high current densities. The self-assembly of PEO and bacterial cellulose by hydrogen bonding reduces the crystallinity of PEO and increases uniformly the distribution of lithium ions. With excellent flexibility and thermal stability, such a 3D polymer solid-state electrolyte exhibits an enhanced electrochemical stability window of 5.8 V versus Li/Li+ potential and a high ionic conductivity of 1.28 × 10-4 S cm-1 at 60 °C. The Li|BC-PEO-Cs+|Li symmetric cells operate stably for more than 1000 h. Furthermore, Li|BC-PEO-Cs+|LiFePO4 (LFP) cells show remarkable enhancement in capacity (163.4 mA h g-1 at 0.1 C), cycling stability (with a capacity retention of 96% after 500 cycles at 1 C) and high functionality and safety (withstanding folding and cutting) in practical applications.

18.
J Food Sci Technol ; 58(5): 1655-1662, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33897004

RESUMO

Button mushrooms (Agaricus bisporus) were put under stimulated storage and transportation environments with different amounts of phase-change materials (PCM). Results showed that the addition of PCM effectively maintained a cooler environment and delayed a rise in temperature. And the addition of PCM, especially in a ratio 1:2 PCM:mushroom, had a significant effect on delaying the increase in cell membrane permeability, malondialdehyde and H2O2 levels, and also delayed superoxide dismutase and catalase activity. These results suggest that PCM may be candidate in postharvest mushroom during storage and transportation.

19.
Phys Rev Lett ; 126(8): 084801, 2021 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-33709748

RESUMO

The spectroscopic techniques for time-resolved fine analysis of matter require coherent x-ray radiation with femtosecond duration and high average brightness. Seeded free-electron lasers (FELs), which use the frequency up-conversion of an external seed laser to improve temporal coherence, are ideal for providing fully coherent soft x-ray pulses. However, it is difficult to operate seeded FELs at a high repetition rate due to the limitations of present state-of-the-art laser systems. Here, we report a novel self-modulation method for enhancing laser-induced energy modulation, thereby significantly reducing the requirement of an external laser system. Driven by this scheme, we experimentally realize high harmonic generation in a seeded FEL using an unprecedentedly small external laser-induced energy modulation. An electron beam with a laser-induced energy modulation as small as 1.8 times the slice energy spread is used for lasing at the seventh harmonic of a 266-nm seed laser in a single-stage high-gain harmonic generation (HGHG) setup and the 30th harmonic of the seed laser in a two-stage HGHG setup. The results mark a major step toward a high-repetition-rate, fully coherent x-ray FEL.

20.
J Biomech Eng ; 143(7)2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-33704377

RESUMO

Skull fracture is a common finding for both accidental and abusive head trauma in infants and young children, and may provide important clues as to the energy and directionality of the event leading to the skull fracture. However, little is understood regarding the mechanics of skull fracture in the pediatric skull, and how accidental fall parameters contribute to skull fracture patterns. The objectives of this research were to utilize a newly developed linear elastic fracture mechanics finite element model of infant skull fracture to investigate the effect of impact angle and fall height on the predictions of skull fracture patterns in infants. Nine impact angles of right parietal bone impacts were simulated from three different heights onto a rigid plate. The average ± standard deviation of the distance between the impact location and fracture initiation site was 8.0 ± 5.9 mm. Impact angle significantly affected the fracture initiation site (p < 0.0001) and orientation (p < 0.0001). A 15 deg variation in impact angle changed the initiation site up to 47 mm. The orientation of the fracture pattern was dependent on the impact location and ran either horizontal or vertical toward the ossification center of the bone. Fall height significantly affected the fracture length (p = 0.0356). Specifically, at the same impact angle, a 0.3 m increase in fall height increased the skull fracture length by 21.39 ± 34.26 mm. These data indicate that environmental variability needs to be carefully considered when evaluating infant skull fracture patterns from low-height falls.


Assuntos
Acidentes por Quedas
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...