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1.
Artigo em Inglês | MEDLINE | ID: mdl-36662352

RESUMO

Rapid industrial and agricultural development as well as urbanization affect the water environment significantly, especially in sub-watersheds where the contaminants/constituents present in the pollution sources are complex, and the flow is unstable. Water quality assessment and quantitative identification of pollution sources are the primary prerequisites for improving water management and quality. In this work, 168 water samples were collected from seven stations throughout 2018-2019 along the Laixi River, a vital pollution control unit in the upper reaches of the Yangtze River. Multivariate statistics and positive matrix factorization (PMF) receptor modeling techniques were used to evaluate the characteristics of the river-water quality and reveal the pollution sources. Principal component analysis was employed to screen the crucial parameters and establish an optimized water quality assessment procedure to reduce the analysis cost and improve the assessment efficiency. Cluster analysis further illustrates the spatiotemporal distribution characteristics of river-water quality. Results indicated that high-pollution areas are concentrated in the tributaries, and the high-pollution periods are the spring and winter, which verifies the reliability of the evaluation system. The PMF model identified five and six potential pollution sources in the cold and warm seasons, respectively. Among them, pollution from agricultural activities and domestic wastewater shows the highest contributions (33.2% and 30.3%, respectively) during the cold and warm seasons, respectively. The study can provide theoretical support for pollutant control and water quality improvement in the sub-watershed, avoiding the ecological and health risks caused by the deterioration of water quality.

3.
Eur J Pharmacol ; : 175438, 2023 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-36682482

RESUMO

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease, and its 5-year mortality rate is even higher than the mortality rate of some cancers. Fibrosis can cause irreversible damage to lung structure and function. Treatment options for IPF remain limited, and there is an urgent need to develop effective therapeutic drugs. Protease activated receptor-1 (PAR-1) is a G-protein-coupled receptor and is considered a potential target for the treatment of fibrotic diseases. Vorapaxar is a clinically approved PAR-1 antagonist for cardiovascular protection. The purpose of this study was to explore the potential effect and mechanism of Vorapaxar on pulmonary fibrosis in vivo and in vitro. In the experimental animal model, Vorapaxar can effectively alleviate bleomycin (BLM)-induced pulmonary fibrosis. Treatment with 2.5, 5 or 10 mg/kg Vorapaxar once a day reduced the degree of fibrosis in a dose-dependent manner. The expression of fibronectin, collagen and α smooth muscle actin decreased significantly at the messenger RNA (mRNA) and protein levels in treated mice. In vitro, our results showed that Vorapaxar could inhibit the activation of fibroblasts induced by thrombin in a dose-dependent manner. In terms of mechanism, Vorapaxar inhibits the signal transduction of JAK2/STAT1/3 by inhibiting the activation of protease activated receptor 1, which reduces the expression of HSP90ß and the interaction between HSP90ß and transforming growth factor-ß (TGFß) receptor II and inhibits the TGFß/Smad signaling pathway. In conclusion, Vorapaxar inhibits the activation of pulmonary fibroblasts induced by thrombin by targeting protease activated receptor 1 and alleviates BLM-induced pulmonary fibrosis in mice.

4.
Adv Mater ; : e2210038, 2023 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-36688671

RESUMO

Filter capacitors (FCs) are substantial for digital circuits and microelectronic devices, and thus more compact FCs are eternally demanded for system miniaturization. Even though microsupercapacitors are broadly regarded as an excellent candidate for the future FCs, yet due to the limitation of available electrode materials, the capacitive performance of reported MSCs drops sharply under high-frequency alternating current. Herein, we present a unique laser induced transient self-organization strategy, which synergizes pulsed laser energy and multi-physical field controlled coalescence processes, leading to the rapid and controllable preparation of titanium nitride ultrafine nano-filaments (diameter approximately 3-5 nm) networks. Their chaotic fractal nanoporous structure, superior specific surface area and excellent conductivity render these nanostructures promising candidates for FCs. Surface-mounted filter capacitors based on this electrode material exhibit ultra-long cycle-life (2,000,000 cycles) with record ultrahigh volumetric energy density of 9.17 mWh cm-3 at 120 Hz in aqueous electrolyte, displaying advantages in function, size and integratability compared with the state-of-the-art aluminum electrolytic capacitors. The method here provides a versatile toolbox for designing novel nanostructures with intriguing characteristics and insights for developing advanced and miniaturized filter and power devices. This article is protected by copyright. All rights reserved.

5.
Int Nurs Rev ; 2023 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-36708510

RESUMO

AIM: This study examined the correlation among turnover intention, emotional intelligence and job burnout in male nurses and determined its influencing factors. BACKGROUND: The number of male nurses has increased in China; however, the turnover rate is very high. Nurses' turnover intention is related to job burnout and emotional intelligence. INTRODUCTION: Recent studies have shown that job burnout and emotional intelligence are related to medical and health institution employees' intention to leave their jobs. It is not clear if the same conclusions can be drawn about male nurses. METHODS: For this cross-sectional study, 627 male nurses were recruited from across China between May and July 2018. Data were collected through an online questionnaire, and Pearson's product-moment correlation coefficient and multiple linear regression were performed to analyse the data. RESULTS: There was a weak negative, moderate positive and moderate negative correlation between turnover intention and emotional intelligence, turnover intention and job burnout, and emotional intelligence and job burnout, respectively. Factors that significantly affected turnover intention among male nurses included job burnout, young age, lack of interest in nursing and working in the emergency department. CONCLUSION: The study revealed the factors that affected male nurses' turnover intention and the relationships between turnover intention, emotional intelligence and job burnout. IMPLICATIONS FOR NURSING MANAGEMENT AND SOCIAL POLICY: Hospital managers should provide necessary help and support to reduce male nurse turnover rates and incorporate emotional intelligence training. The policy should eliminate the unfair college admission practices for students choosing nursing majors, raise the nursing profession's salaries and vigorously develop specialty nursing. In addition, diversified values should be promoted, and stereotypes of male nurses in nursing should be broken.

6.
Cogn Res Princ Implic ; 8(1): 1, 2023 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-36600082

RESUMO

Despite numerous investigations of the prevalence effect on medical image perception, little research has been done to examine the effect of expertise, and its possible interaction with prevalence. In this study, medical practitioners were instructed to detect the presence of hip fracture in 50 X-ray images with either high prevalence (Nsignal = 40) or low prevalence (Nsignal = 10). Results showed that compared to novices (e.g., pediatricians, dentists, neurologists), the manipulation of prevalence shifted participant's criteria in a different direction for experts who perform hip fracture diagnosis on a daily basis. That is, when prevalence rate is low (pfracture-present = 0.2), experts held more conservative criteria in answering "fracture-present," whereas novices were more likely to believe there was fracture. Importantly, participants' detection discriminability did not vary by the prevalence condition. In addition, all participants were more conservative with "fracture-present" responses when task difficulty increased. We suspect the apparent opposite criteria shift between experts and novices may have come from medical training that made novices to believe that a miss would result in larger cost compared to false positive, or because they failed to update their prior belief about the signal prevalence in the task, both would suggest that novices and experts may have different beliefs in placing the optimal strategy in the hip fracture diagnosis. Our work can contribute to medical education training as well as other applied clinical diagnosis that aims to mitigate the prevalence effect.


Assuntos
Fraturas do Quadril , Humanos , Prevalência , Fraturas do Quadril/diagnóstico por imagem , Fraturas do Quadril/epidemiologia
7.
Sensors (Basel) ; 23(1)2023 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-36617085

RESUMO

Fused deposition modeling (FDM) is a form of additive manufacturing where three-dimensional (3D) models are created by depositing melted thermoplastic polymer filaments in layers. Although FDM is a mature process, defects can occur during printing. Therefore, an image-based quality inspection method for 3D-printed objects of varying geometries was developed in this study. Transfer learning with pretrained models, which were used as feature extractors, was combined with ensemble learning, and the resulting model combinations were used to inspect the quality of FDM-printed objects. Model combinations with VGG16 and VGG19 had the highest accuracy in most situations. Furthermore, the classification accuracies of these model combinations were not significantly affected by differences in color. In summary, the combination of transfer learning with ensemble learning is an effective method for inspecting the quality of 3D-printed objects. It reduces time and material wastage and improves 3D printing quality.


Assuntos
Plásticos , Impressão Tridimensional , Aprendizagem , Aprendizado de Máquina
8.
Biosensors (Basel) ; 13(1)2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36671978

RESUMO

Herein, a novel nitr[ogen-doped carbon dot (N-CD) fluorescence sensor with a dual emission ratio is developed using the microwave-assisted synthesis of m-phenylenediamine and spermidine. As a result of the fluorescence inner filtration effect (IFE) effect between morphine (MOR) and N-CD, the blue fluorescence of N-CDs at 350 nm was reduced in the presence of MOR, whereas the fluorescence of N-CDs at 456 nm increased substantially. The results demonstrated that the approach has a tremendous potential and that the linear range of MOR detection is 0.25-25 µg/mL, with a 71.8 ng/mL detection limit. Under UV light, the blue fluorescent system is easily visible to the naked eye. More significantly, the sensor proved successful in providing satisfactory results for the speciation measurement of MOR in a variety of biological samples.


Assuntos
Pontos Quânticos , Carbono , Corantes Fluorescentes , Espectrometria de Fluorescência , Derivados da Morfina
9.
Artigo em Inglês | MEDLINE | ID: mdl-36674145

RESUMO

This study adopted an advanced model, combining the technology acceptance model, the theory of reasoned action, the diffusion of innovations, trust, and five aspects of perceived risk, to measure the factors that influence the behavioral intentions of older adults to use mobile payments. A total of 365 questionnaires were collected from older adults aged 55 years or older from 20 community care sites in central Taiwan. Partial least-squares structural equation modeling was used to test our research model. The results showed that attitude was the main determinant of M-payment in older adults. Moreover, increasing the usefulness, ease of use, and observability of M-payment helped older adults improve their attitudes toward M-payment, thereby increasing their intention to use it. Trust had a significant effect on the usefulness and ease of use of M-payment, while the main factors affecting trust were only performance and financial risks.


Assuntos
Atitude , Intenção , Confiança , Modelos Teóricos , Inquéritos e Questionários
10.
In Vivo ; 37(1): 454-460, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36593061

RESUMO

BACKGROUND/AIM: The combination of bevacizumab and atezolizumab (Bev-Ate) has been established as a standard first-line systemic treatment option for unresectable hepatocellular carcinoma (HCC) since 2020. This study examined the outcomes of HCC patients who received the combination in southern Taiwan. PATIENTS AND METHODS: All patients were enrolled from four hospitals in Taiwan. They received Bev-Ate therapy for unresectable HCC. RESULTS: Thirty-five patients were included; 28 (80%) had Barcelona Clinic Liver Cancer stage C disease. Hepatitis etiology was chronic hepatitis B and C in 63% and 17% of patients, respectively. Eleven (31%) patients had received prior systemic treatment for unresectable HCC. The response rate was 51%, and the disease control rate was 72% for all patients. The median progression-free survival (PFS) and overall survival (OS) was 5.2 and 22.2 months, respectively. For patients who received prior systemic treatment, the efficacy of Bev-Ate in terms of response rates was similar compared with those without prior systemic treatment. Patients who received lower doses of bevacizumab (<15 mg/kg per dose) had non-inferior PFS and OS compared with those receiving a standard dose of bevacizumab. The incidence of proteinuria of all grades (15.8%) was less common when lower doses of bevacizumab were used. CONCLUSION: Real world data from HCC patients in southern Taiwan disclosed that the efficacy outcomes of Bev-Ate treatment were generally consistent with those of clinical trials in other countries. In patients who were exposed to prior systemic treatment or who received lower doses of bevacizumab, the Bev-Ate regimen retained its clinical efficacy.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica , Carcinoma Hepatocelular , Neoplasias Hepáticas , Humanos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Bevacizumab/uso terapêutico , Carcinoma Hepatocelular/tratamento farmacológico , Neoplasias Hepáticas/tratamento farmacológico , Taiwan/epidemiologia
11.
PLoS Negl Trop Dis ; 17(1): e0011012, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36638133

RESUMO

BACKGROUND: This study aimed to determine the impact of co-infection of Clonorchis sinensis (CS) and hepatitis B virus (HBV) on the prognosis of patients with hepatocellular carcinoma (HCC) following hepatectomy. METHODS: The clinicopathological information of 946 patients with HCC following hepatectomy was retrospectively analyzed. The patients were divided into four groups depending on whether they had CS infection and/or HBV infection: double-negative group (infected with neither CS nor HBV), simple CS group (infected with only CS), simple HBV group (infected with only HBV), and double-positive group (co-infected with CS and HBV). Kaplan-Meier curves were used to evaluate the overall survival (OS) and recurrence-free survival (RFS), while log-rank tests were used to compare survival rates. Further, Cox regression was used to perform both univariate and multivariate survival analyses to identify variables linked to the prognosis of HCC. RESULTS: The median overall survival (OS) and recurrence-free survival (RFS) in the double-positive, simple CS, simple HBV, and double-negative groups were 27 months and 9 months, 20 months and 7 months, 44 months and 12 months, and 42 months and 17 months, respectively. The double-positive group's 1-year, 3-year, and 5-year OS and RFS rates were 79.2% and 46.9%, 62.6% and 28.4%, 47.8%, and 12.2%, respectively. The simple CS group's 1-year, 3-year, and 5-year OS and RFS rates were 86.3% and 41.5%, 56.5% and 27.7%, 50.2%, and 18.5%, respectively. The simple HBV group's 1-year, 3-year, and 5-year OS and RFS rates were 89.8% and 56.0%, 72.5% and 30.5%, 63.8%, and 19.9%, respectively. The double-negative group's 1-year, 3-year, and 5-year OS and RFS rates were 91.5% and 62.3%, 76.1% and 32.9%, 64.0%, and 22.4%, respectively. Further, according to a Cox multivariate analysis, tumor size (> 5cm), Edmonson grade (III-IV), BCLC-C stage, and tumor satellite focus were independent risk factors for RFS and OS in patients with HCC. CONCLUSION: Patients with HCC and Clonorchis sinensis infection experience a poor prognosis after hepatectomy, regardless of whether they are co-infected with HBV.

12.
Artigo em Inglês | MEDLINE | ID: mdl-36640120

RESUMO

Constructing efficient artificial surface electrolyte interface (SEI) film is extremely vital for the practical application of lithium metal batteries. Herein, a dense artificial SEI film, in which lithiophilic Zn/LixZny are uniformly but nonconsecutively dispersed in the consecutive Li+-conductors of LixSiOy, Li2O and LiOH, is constructed via the in-situ reaction of layered zinc silicate nanosheets and Li. The consecutive Li+-conductors can promote the desolvation process of solvated-Li+ and regulate the transfer of lithium ions. The nonconsecutive lithiophilic metals are polarized by the internal electric field to boost the transfer of lithium ions, and lower the nucleation barrier. Therefore, a low polarization of ~50 mV for 750 h at 2.0 mA cm-2 in symmetric cells, and a high capacity retention of 99.2% in full cells with a high LFP areal loading of ~13 mg cm-2 are achieved. This work offers new sights to develop advanced alkali metal anodes for efficient energy storage.

13.
Orthop J Sports Med ; 11(1): 23259671221143459, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36644778

RESUMO

Background: There is limited research investigating the diagnostic strength of 3-dimensional computed tomography (3D-CT) and multidirectional CT arthrography (CTA) for femoroacetabular impingement (FAI) and related hip lesions. Purpose: To evaluate the diagnostic strength of combined 3D-CT and CTA in patients with FAI and related hip lesions by comparing it with hip arthroscopic surgery findings. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: This study included patients who were suspected of having FAI and related hip lesions and who underwent a combination of 3D-CT and CTA and subsequent hip arthroscopic surgery between December 2013 and December 2017. The CT and intraoperative arthroscopic findings were recorded and compared. The sensitivity, specificity, and accuracy of 3D-CT for FAI and those of CTA for related hip lesions were calculated. Results: A total of 114 patients with 114 hips were included in our study. There were 101 patients with positive findings and 13 patients with negative findings for FAI (including cam, pincer, and combined morphology) according to 3D-CT. The sensitivity, specificity, and accuracy of 3D-CT for FAI were 91.58%, 57.14%, and 89.47%, respectively. The sensitivity, specificity, and accuracy of CTA for labral tears were 94.64%, 100.00%, and 94.73%, respectively. For acetabular cartilage defects, the sensitivity, specificity, and accuracy of CTA were 60.71%, 91.37%, and 76.31%, respectively. For femoral cartilage defects, the sensitivity, specificity, and accuracy of CTA were 82.22%, 76.81%, and 78.94%, respectively. Conclusion: The study results indicated that 3D-CT was able to provide excellent accuracy for FAI compared with hip arthroscopic surgery findings. In addition, multidirectional CTA demonstrated promising diagnostic strength for hip lesions such as labral tears and chondral defects.

14.
J Pathol ; 2023 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-36656126

RESUMO

The Ki-67 labeling index (Ki-67 LI) is a strong prognostic marker in prostate cancer, although its analysis requires cumbersome manual quantification of Ki-67 immunostaining in 200-500 tumor cells. To enable automated Ki-67 LI assessment in routine clinical practice, a framework for automated Ki-67 LI quantification, which comprises three different artificial intelligence analysis steps and an algorithm for cell-distance analysis of multiplex fluorescence immunohistochemistry staining (mfIHC), was developed and validated in a cohort of 12,475 prostate cancers. The prognostic impact of the Ki-67 LI was tested on a tissue microarray (TMA) containing one sample each patient. A "heterogeneity TMA" containing 3 to 6 samples from different tumor areas each patient was used to model Ki-67 analysis of multiple different biopsies and 30 prostate biopsies were analyzed to compare a "classical" bright field-based Ki-67 analysis with the mfIHC-based framework. The Ki-67 LI provided strong and independent prognostic information in 11,845 analyzed prostate cancers (p<0.001 each) and excellent agreement was found between the framework for automated Ki-67 LI assessment and the manual quantification in prostate biopsies from routine clinical practice (intraclass correlation coefficient: 0.94 [95% CI: 0.87 - 0.97]). The analysis of the heterogeneity TMA revealed that the Ki-67 LI of the sample with the highest Gleason score (AUC:0.68) was as prognostic as the mean Ki-67 LI of all six foci (AUC:0.71 [p=0.24]). The combined analysis of the Ki-67 LI and Gleason score obtained on identical tissue spots showed that the Ki-67 LI added significant additional prognostic information in case of classical ISUP grades (AUC:0.82 [p=0.002]) and quantitative Gleason score (AUC:0.83 [p=0.018]). The Ki-67 LI is a powerful prognostic parameter in prostate cancer, which is now applicable in routine clinical practice. In case of multiple cancer positive biopsies, the sole automated analysis of the worst biopsy was sufficient. This article is protected by copyright. All rights reserved.

15.
J Biochem Mol Toxicol ; : e23301, 2023 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-36644941

RESUMO

This study investigates the therapeutic effect and the underlying mechanisms of ergothioneine (EGT) on the testicular damage caused by varicocele (VC) in vivo, in vitro, and in silico. This preclinical study combines a series of biological experiments and network pharmacology analyses. A total of 18 Sprague Dawley (SD) male rats were randomly and averagely divided into three groups: the sham-operated, VC model, and VC model with EGT treatment (VC + EGT) groups. The left renal vein of the VC model and the VC + EGT groups were half-ligated for 4 weeks. Meanwhile, the VC + EGT group was intragastrically administrated with EGT (10 mg/kg). GC1 and GC2 cells were exposed to H2 O2 with or without EGT treatment to re-verify the conclusion. The structure disorder of seminiferous tubules ameliorated the apoptosis decrease in the VC rats receiving EGT. EGT can also increase the sperm quality of the VC model rats (p < 0.05). The exposure to H2 O2 decreased proliferation and increased apoptosis of GC1 and GC2 cells, which was revisable by adding EGT to the plates (p < 0.05). The network pharmacology and molecular docking were conducted to explore the potential targets of EGT in VC, and HSP90AA1 was identified as the pivotal gene, which was validated by western blot, immunohistochemistry, and RT-qPCR both in vivo and in vitro (p < 0.05). Overall, EGT attenuates the testicular injury in the VC model both in vivo and in vitro by potentially potentiating the expression of HSP90AA1.

16.
Anal Chem ; 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36651064

RESUMO

Cell cycle is a significant factor toward cellular heterogeneity, so cell cycle discrimination is a precise measurement on the top of single-cell analysis. Single-cell analysis based on organic mass spectrometry has received great attention for its unique ability to profile single-cell metabolome, but the influence of cell cycle on cellular metabolome heterogeneity has been overlooked until now due to the lack of a compatible cell cycle discrimination method. Here, we report a robust protocol based on the combination of three small molecular indicators, consisting of two small molecular labels (Hoechst and docetaxel) and one cellular endogenous compound [phosphocholine (34:1)], to discriminate single cells at different cycle stages in real time by organic mass cytometry. More than 6000 HeLa cells were acquired by an improved organic mass cytometry system to build a cell cycle differentiation model. The model successfully discriminated single HeLa cells, SCC7, and Hep G2 cells, at G0/G1, S, and G2/M stages with larger than 85% sensitivity and larger than 89% specificity. Along with cell cycle discrimination, obvious heterogeneity of amino acids, nucleotides, energy metabolic intermediates, and phospholipids was observed among single cells at different cycle stages by this protocol, further demonstrating the necessity of cell cycle discrimination for cellular metabolome heterogeneity research and the potential of more endogenous small molecular compounds for cell cycle discrimination.

17.
J Cell Mol Med ; 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36651446

RESUMO

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease that seriously threatens the health of patients. The pathogenesis of IPF is still unclear, and there is a lack of effective therapeutic drugs. Myofibroblasts are the main effector cells of IPF, leading to excessive deposition of extracellular matrix (ECM) and promoting the progression of fibrosis. Inhibiting the excessive activation and relieving autophagy blockage of myofibroblasts is the key to treat IPF. PI3K/Akt/mTOR pathway plays a key regulatory role in promoting fibroblast activation and autophagy inhibition in lung fibrosis. Duvelisib is a PI3K inhibitor that can simultaneously inhibit the activities of PI3K-δ and PI3K-γ, and is mainly used for the treatment of relapsed/refractory chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma tumour (SLL). In this study, we aimed to examine the effects of Duvelisib on pulmonary fibrosis. We used a mouse model of bleomycin-induced pulmonary fibrosis to evaluate the effects of Duvelisib on pulmonary fibrosis in vivo and further explored the potential pharmacological mechanisms of Duvelisib in lung fibroblasts in vitro. The in vivo experiments showed that Duvelisib significantly alleviated bleomycin-induced collagen deposition and improved pulmonary function. In vitro and in vivo pharmacological experiments showed that Duvelisib dose-dependently suppressed lung fibroblast activation and improved autophagy inhibition by inhibiting the phosphorylation of PI3K, Akt and mTOR. Our results indicate that Duvelisib can alleviate the severity of pulmonary fibrosis and provide potential drugs for the treatment of pulmonary fibrosis.

18.
Artigo em Inglês | MEDLINE | ID: mdl-36652350

RESUMO

Use of abiotic chemical systems for understanding higher order superstructures is challenging. Here we report a ring-in-ring(s) system comprising a hydrogen-bonded macrocycle and cyclobis(paraquat-o-phenylene) tetracation ( o-Box) or cyclobis(paraquat-p-phenylene) tetracation (CBPQT4+, p-Box) that fulfills the construction of discrete higher order structures with adaptive conformation. As indicated by mass spectrometry, computational modeling, NMR, and single crystal X-ray diffraction, this ring-in-ring(s) system features the box-directed aggregation of multiple macrocycles, leading to generation of several stable species such as H4G (1a/ o-Box) and H5G (1a/ o-Box). Remarkably, a dimeric shish-kebab-like ring-in-rings superstructure H7G2 (1a/ o-Box) or H8G2 (1a/ p-Box) is formed from the coaxial stacking of two ring-in-rings units. The formation of such unique dimeric superstructures is attributed to the large π-surface of this 2D planar macrocycle and the conformational variation of both host and guest.

19.
Int J Med Sci ; 20(1): 70-78, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36619233

RESUMO

Background: Chest compressions are the basis of cardiopulmonary resuscitation (CPR), and high-quality chest compressions can improve survival rate in patients with out-of-hospital cardiac arrest. Although many efforts have been made to improve the quality of CPR in inexperienced adults, the results are still not high, especially during emergencies. The primary purpose of this study is to investigate whether a brief instructional chest compression-only CPR video could improve chest compression quality in inexperienced adults. Methods: One hundred adults with no CPR experience (age: 20.28 ± 2.28 years; women: 50, men: 50) participated in this study. Participants completed body composition and handgrip strength measurements, and performed two CPR quality tests on the Laerdal® Little Anne QCPR Manikin, namely without video-CPR (WV-CPR) and video-CPR (V-CPR). The WV-CPR quality test was performed first. After 2 minutes of continuous chest compression, the participants rested for 10 seconds and repeated 3 cycles (phase 1, phase 2, and phase 3). After resting for more than 72 hours, V-CPR quality test was conducted. During the V-CPR with video intervention, the participants also continued to compress the chest for 2 minutes, and then rested for 10 seconds, repeating 3 cycles. Results: In phase 1, compared with WV-CPR, the V-CPR has a significant increase (p < 0.001) in chest compression fraction (CCF) (56.31 ± 33.22% vs. 41.82 ± 32.30%) and percent of correct compression rate (PCCR) (96.17 ± 8.45% vs. 26.31 ± 37.55%). In addition, the V-CPR has significantly lower (p < 0.001) chest compression rate (CCR) (110.85 ± 2.40 cpm vs. 128.86 ± 24.52 cpm) and rating of perceived exertion (RPE) (11.89 ± 2.25 vs. 12.87 ± 2.25). For phases 2 through 3, V-CPR and WV-CPR achieved significant differences in CCF, CCD, CCR, PCCR, and RPE (p < 0.01). There were significant differences (p < 0.05) in CCF, CCD, chest compression rebound rate, and RPE among the different administration stages of both WV-CPR and V-CPR. Conclusions: The results of this study revealed that a brief instructional chest compression-only CPR video could improve chest compression quality for inexperienced adults by reducing fatigue and CCR, and increasing CCF and PCCR.


Assuntos
Reanimação Cardiopulmonar , Parada Cardíaca Extra-Hospitalar , Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Reanimação Cardiopulmonar/métodos , Fadiga , Força da Mão , Tórax , Manequins
20.
J Dent Sci ; 18(1): 374-381, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36643243

RESUMO

Background/purpose: Little is known regarding the outcomes and distinguishing characteristics of lawsuits related to endodontic procedures. This study used a verdict-based data from United States of America to analyze the factors associated with endodontic malpractice lawsuits and mitigate the risk of litigation. Materials and methods: The LexisNexis legal database was used to search for endodontic malpractice cases from January 1, 2000 to December 31, 2021 using the terms "medical malpractice" and (I) "endodontist" (II) "endodontics" (III) "root canal" (IV) "dental pulp." Each case was reviewed for reported medical characteristics and litigation outcomes. Results: A total of 650 cases were initially identified, and 97 cases were included in the final analysis. Eighty-four (86.6%) of the 97 defendants were general practitioners; 42 cases favored the plaintiff, 53 (54.6%) favored the defendant, 1 was partial win/loss, and 1 was settled. The annual case mean was 4.41 ± 2.17 (Mean ± SD). The major allegations favored for the patients involving paresthesia, root perforation, rubber dam not use, wrong tooth therapy, and infections. Plaintiffs who claimed with post-procedural reasons had a significantly higher winning rate than non-post-procedural reasons (P < 0.05). Conclusion: In the present study, 54.6% of endodontic litigation favored the dentists in the US. The authors recommend that general practitioners refer complicated cases to endodontists and treat carefully to avoid paresthesia, canal perforation and infections. Clinicians should always diagnose and treat correctly, shared decision making with the patient, use rubber dam routinely, and timely management to prevent malpractice claims.

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