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1.
Zhonghua Liu Xing Bing Xue Za Zhi ; 32(10): 1037-42, 2011 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-22333091

RESUMO

OBJECTIVE: To evaluate the associations between polymorphisms of LEPR Gln223Arg, LEPR Pro1019Pro and the risk on obesity. METHODS: A computerized search on literature was carried out in Wanfang, CNKI, VIP databases and CBM, PubMed, EMBASE databases to collect articles published between 1979 and 2010 concerning the associations between polymorphisms of LEPR Gln223Arg and/or LEPR Pro1019Pro and risk of obesity in the Chinese population. Odds ratios (ORs) were used to assess the strength of the association, and 95% confidence intervals (CIs) to present the precision of the estimates. Meta-analysis was performed using the STATA statistical software. RESULTS: Fifteen literature were collected for Meta-analysis by the uniform inclusion and exclusion criteria. There were 1096 obese patients and 949 controls for polymorphisms of LEPR Gln223Arg in 9 papers, together with 961 obese patients and 818 controls for polymorphisms of LEPR Pro1019Pro in 8 papers. Overall, there were significant associations between decreased risk of obesity and LEPR Gln223Arg polymorphisms (-668 A→G) (G versus A, OR = 0.66, 95%CI: 0.49 - 0.89; AG and GG versus AA, OR = 0.50, 95%CI: 0.32 - 0.77; respectively). There were significant associations between increased risk of obesity and LEPR Pro1019Pro polymorphisms (-3057 G→A) (A versus G, OR = 1.61, 95%CI: 1.15 - 2.26; AG and AA versus GG, OR = 1.50, 95%CI: 1.08 - 2.08; respectively). CONCLUSION: Variant alleles at both LEPR-668 and LEPR-3057 were associated with obesity in the Chinese Han-dominated population.


Assuntos
Obesidade/genética , Receptores para Leptina/genética , Grupo com Ancestrais do Continente Asiático/genética , Frequência do Gene , Genótipo , Humanos , Razão de Chances , Polimorfismo Genético
2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 45(10): 944-8, 2011 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-22321599

RESUMO

OBJECTIVE: To comprehensively evaluate the effect of interventions on obesity in Chinese pupils. METHODS: A literature research was carried out in China National Knowledge Infrastructure, Wanfang Data, VIP Database for Chinese Technical Periodicals, PubMed and the Excerpts Medica Database (EMBASE) databases to collect articles published between 1979 and 2010 concerning the effect of interventions for preventing obesity in Chinese pupils. Rate difference (RD) of the rate of obesity as the evaluation indicator was selected to Meta-analyze the effect of interventions on obesity. There are total 215 articles, in which 211 articles were written in Chinese and other articles were written in English. RESULTS: 17 literatures were used for Meta-analysis by the uniform inclusion and exclusion criteria. The results showed that the RD of obesity rate for the students in the intervention group was 3% (95%CI: 1% - 5%) after the intervention. However, the RD of obesity rate for the students in the control group was -2% (95%CI: -4% - -1%) after the intervention. Results of stratified analysis for the RD of obesity rate showed that the obesity rate for the students in the intervention group were decreased significantly after the intervention of combined programs with health education, physical exercise and nutrition interventions with moderate intervention time (1 to 2 years), the RD (95%CI) of obesity rate were 5% (2% - 8%), 3% (1% - 4%), respectively. For the studies whose baseline obesity rates was insignificant difference between the intervention group and the control group, the obesity rate for the students in the intervention group was 4% (95%CI: -7% - -1%) lower than the obesity rate for the students in the control group after the intervention. CONCLUSION: Health-education-based comprehensive intervention is effective on obesity prevention in Chinese pupils; combined intervention programs with moderate intervention time (1 to 2 years) were effective in improving efficiency of obesity prevention in pupils.


Assuntos
Educação em Saúde , Obesidade/prevenção & controle , Criança , China , Humanos , Estudantes
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