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1.
Nat Prod Res ; : 1-6, 2020 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-32380855

RESUMO

A new alkylresorcinol, myrothecol A (1), along with two known ones (2 and 3), were isolated from a fungal strain Myrothecium sp. GY170016. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by electronic circular dichroism experiment. This is the first case of the presence of alkylresorcinols in genus Myrothecium. All the isolates were evaluated for their cytotoxic activities against human cancer cell line MCF-7 with IC50 values of 16.7, 13.2, 21.3 µM, respectively.

2.
J Chromatogr A ; 1609: 460510, 2020 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-31515077

RESUMO

In this study, a novel phenyl-boronic acid polymeric monolith (PBAPM) in polyether ether ketone (PEEK) tube was fabricated. The inner wall of PEEK tube was modified with mussel inspired polydopamine layer to firmly bond PBAPM, so as to avoid the outflow of PBAPM from PEEK tube and improve the service life and application scope of PBAPM. The PBAPM was synthesized by initiator-free ring-opening polymerization based on our previous work. The boric acid groups provided B-N coordination sites, as well as the hydrophobic amino and epoxy monomers provided hydrophobic interaction sites. Due to the synergistic effect of hydrophobic interaction and B-N coordination, the PBAPM exhibited excellent binding amounts for nitrogen-containing sulfonamides (SAs). In addition, the PBAPM possessed excellent stability, rigidity and permeability. Therefore, the PBAPM was used as solid phase microextraction (SPME) material for enrichment and separation of SAs from aqueous samples. The PBAPM SPME was optimized in detail, and combined with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis for simultaneous determination of 10 kinds of SAs from tap, lake and river water. Using only 1 mL of water samples, limit of quantitation of SAs could reach 0.54-4.5 ng L-1. Recoveries of standard spiked SAs from water samples were between 82.0% and 105.4%, with intra-day and inter-day relative standard deviation ranging from 3.3% to 5.6% and 4.2% to 8.1%, respectively. The PBAPM SPME combined with UPLC-MS/MS method shown better or similar recoveries, and used fewer samples than previous methods. These results demonstrated that the PBAPM could selectively separate and enrich ultra-trace nitrogen-containing SAs from aqueous samples.


Assuntos
Ácidos Borônicos/química , Cromatografia Líquida de Alta Pressão/métodos , Polimerização , Polímeros/química , Microextração em Fase Sólida , Sulfonamidas/análise , Espectrometria de Massas em Tandem/métodos , Sulfonamidas/química , Água/química , Poluentes Químicos da Água/análise
3.
Curr Med Sci ; 39(2): 270-277, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31016521

RESUMO

Non-anatomical liver resection with appropriate resection margin is regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients. But occurrence of cutting surface related complications becomes a main challenge. From June 2010 to June 2016, 448 patients with major hepatic carcinoma received non-anatomical liver resection in our liver surgery center. After excluding 66 cases that were incongruent with the purpose of study, 235 patients undergoing transparenchymal compressing suture (TCS) to "not good" cutting surface were allocated as study group; 147 patients with exposed surface (ES) were matched as control group. The characteristics of postoperative drainage, postoperative hepatic and renal functions, hospital days, and outcomes were collected retrospectively. We further compared cutting surface related complications under different levels of liver cirrhosis between the two groups. Compared with ES group, patients in TCS group had a decreased incidence of cutting surface related complications (14.3% vs. 6.8%, P=0.011) and a decreased probability of interventions for cutting surface related complications (8.2% vs. 3.4%, P=0.042). TCS application was much more effective to prevent cutting surface related complications in patients with moderate and severe cirrhosis (5.4% vs. 15.8%, P=0.003). Postoperative hepatic and renal function, hospital days and mortality did not differ between the two groups. In conclusion, TCS decreases the probability of cutting surface related complications and postoperative interventions for related complications, especially in patients with moderate and severe cirrhosis.


Assuntos
Carcinoma Hepatocelular/cirurgia , Hepatectomia/efeitos adversos , Neoplasias Hepáticas/cirurgia , Fígado/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Feminino , Humanos , Cirrose Hepática/etiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Suturas
4.
J Chromatogr A ; 1590: 10-18, 2019 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-30609959

RESUMO

Boronate affinity materials are usually used for selective enrichment of cis-diol-containing compounds, mainly based on formation of pH-dependent cyclic ester between cis-diol and boronic acid. Recently, B-N coordination, or combined with hydrogen-bonding interaction, was employed as primary interaction for the extraction of nitrogen-containing compounds. However, there are no reports about the combination of hydrophobic (or π-π) interaction and B-N coordination for the extraction. Here, we prepared a novel hydrophobic phenyl-boronic acid polymer (PBAP) through initiator-free ring-opening polymerization. The adsorption experiment indicated that the PBAP could combine hydrophobic (or π-π) interaction and B-N coordination to enhance their adsorption capacity toward hydrophobic and nitrogen-containing compounds, for example sulfamethoxazole (SMX) and trimethoprim (TMP). In addition, the PBAP monolith synthesized in pipette tip was used as solid phase microextraction (SPME) sorbent with combination of ultra high performance liquid chromatography to extract and monitor SMX and TMP from animal-originated foodstuffs. The proposed method exhibited low limit of quantitation as 5.0 and 1.0 ng mL-1 for SMX and TMP, respectively. The recoveries at three spiked levels were between 92.4% to 100.5% for SMX, and 92.7% to 102.6% for TMP, with intra-day and inter-day relative standard deviations no more than 5.3% and 8.6%, respectively. These results well demonstrated that the combination of hydrophobic (or π-π) interaction and B-N coordination played an important role in the extraction of hydrophobic and nitrogen-containing compounds.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Resíduos de Drogas , Produtos da Carne/análise , Microextração em Fase Sólida/métodos , Sulfametoxazol , Trimetoprima , Ácidos Borônicos/química , Resíduos de Drogas/análise , Resíduos de Drogas/química , Resíduos de Drogas/isolamento & purificação , Polímeros/química , Sulfametoxazol/análise , Sulfametoxazol/química , Sulfametoxazol/isolamento & purificação , Trimetoprima/análise , Trimetoprima/química , Trimetoprima/isolamento & purificação
5.
Huan Jing Ke Xue ; 39(9): 4385-4392, 2018 Sep 08.
Artigo em Chinês | MEDLINE | ID: mdl-30188084

RESUMO

Living solid waste of 72 typical villages and towns in 12 provinces was investigated, and related heavy metal pollution characteristics, source, and distribution were analyzed. Results showed that heavy metal content of As, Hg, Pb, Cd, Cr, Cu, Zn, and Ni in living solid waste of typical northern villages of China was (7.51±8.89), (0.64±0.42), (21.91±12.29), (4.82±8.37), (86.36±59.99), (36.43±15.98), (62.19±36.61), and (46.07±25.22) mg·kg-1, respectively. Content of As, Hg, Pb, Cd, Cr, Cu, Zn, and Ni in living solid waste of typical southern towns was (7.43±8.82), (0.83±0.74), (21.62±13.76), (1.84±4.55), (131.06±74.96), (37.20±16.80), (98.04±63.71), and (46.75±25.75) mg·kg-1, respectively. Cd and Hg exceeded the standards for urban garbage agricultural control and soil environmental quality. Sources of heavy metals in domestic waste were explored by Pearson correlation analysis, cluster analysis, and principal component analysis. Results showed that Pb and Cd were mainly derived from kitchen waste, dust, paper, rubber, and plastic. Hg was mainly from kitchen waste and dust. Zn and Cr were mainly from dust. Cu was mainly from dust, paper, rubber, plastic, battery, and electronic waste. Ni was mainly from battery and electronic wastes. As was mainly derived from pesticides and fertilizers.

6.
ANZ J Surg ; 88(7-8): E606-E609, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29224239

RESUMO

BACKGROUND: This study introduces an innovative stepwise vascular control technique to address the high risk of massive bleeding from main hepatic veins and the retro-hepatic inferior vena cava during hepatectomy involving hepatocaval confluence. METHODS: From January 2010 to July 2016, 80 patients underwent stepwise vascular occlusion during complex liver resection involving hepatocaval confluence. Relevant clinical data were collected and compared with those obtained in parallel studies. The protocol has been registered in the Protocol Registration and Results System as protocol NCT02996006. RESULTS: All 80 patients underwent portal triad (PT), infra-hepatic inferior vena cava (IIVC) and supra-hepatic inferior vena cava (SIVC) preparation for occlusion in that order; PT, PT + SIVC and PT + IIVC + SIVC occlusions were performed during liver resection for six, 42 and 32 patients, respectively. The PT, IIVC and SIVC clamping times were 12.9 ± 2.5, 9.1 ± 2.1 and 5.1 ± 1.4 min, respectively. The mean blood loss was 504.1 ± 234.5 mL. Sixteen patients received blood transfusions. Haemodynamic parameters remained stable. No patients had life-threatening complications or died (Clavien-Dindo grade IV or V). Compared with other techniques used in parallel studies, this technique has the advantage of decreased blood loss in less warm ischaemia time. CONCLUSION: For complex hepatectomy involving hepatocaval confluence, this newly described stepwise vascular control technique was efficacious and feasible for controlling intraoperative bleeding.


Assuntos
Hepatectomia/métodos , Veias Hepáticas/cirurgia , Fígado/cirurgia , Procedimentos Cirúrgicos Operatórios/métodos , Veia Cava Inferior/cirurgia , Adulto , Perda Sanguínea Cirúrgica/prevenção & controle , Transfusão de Sangue/estatística & dados numéricos , Carcinoma Hepatocelular/cirurgia , Constrição , Feminino , Hemorragia/prevenção & controle , Hepatectomia/efeitos adversos , Humanos , Fígado/irrigação sanguínea , Fígado/patologia , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Operatórios/tendências , Resultado do Tratamento
7.
Hu Li Za Zhi ; 61(2): 95-100, 2014 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-24676956

RESUMO

The treatment of aortic disease previously used conventional open surgery to replace the aorta with artificial vascular prosthesis after resecting the lesioned segment. The recently developed technique of endovascular aneurysm repair (EVAR) uses a stent graft to reinforce the diseased aortic wall while allowing blood flow continuity and preventing further aortic expansion, dissection and aortic rupture. Taiwan's National Health Insurance now covers payment for authorized EVAR procedures, making treatments safer for patients who are elderly, have congestive heart failure, have multiple comorbidities, or have other high-risk factors. EVAR is gradually replacing previous methods to become the primary treatment approach for aortic disease. This article discusses the development of EVAR, indications, operative procedures, complications, postoperative risk factors, and clinical nursing problems. We hope that this article provides new information on nursing care for patients undergoing endovascular aneurysm repair surgery.


Assuntos
Aneurisma Aórtico/cirurgia , Implante de Prótese Vascular/enfermagem , Procedimentos Endovasculares/enfermagem , Serviços de Assistência Domiciliar , Humanos , Stents
8.
Pediatr Neonatol ; 54(1): 34-42, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23445741

RESUMO

BACKGROUND: The effectiveness of education programs for pediatric patients receiving oral antibiotic suspension was unclear. METHODS: When pediatric patients were prescribed antibiotics in powder form for suspension at the outpatient clinic of a university hospital, the responsible 150 caregivers were consecutively allocated into three education programs: Group 1 subjects read the package insert; Group 2 read a photograph-designed educational sheet; and Group 3 received a face-to-face medication education from a pharmacist with the photograph-designed educational sheet. The effectiveness of the three education programs for pediatric patients' caregivers was evaluated using a questionnaire comprised of 12 questions. RESULTS: The proportions of the caregivers in Groups 1, 2 and 3 who answered the questionnaire perfectly with 100% accuracy were 2%, 14% and 74%, respectively (p < 0.001). The means ± standard deviations of the overall time spent by the caregivers in Groups 1, 2 and 3 were 353 ± 135, 334.2 ± 115.1, and 281.4 ± 114 seconds, respectively (p = 0.013). Clearly, the pharmacist's face-to-face mediation education program provided effective and time-saving medication instructions for pediatric oral antibiotics. The specific questions regarding easy-to-make errors related to the reconstitution step (p < 0.001), water volume for reconstitution (p < 0.001), storage temperature (p = 0.004) and shelf life (p = 0.002) of stock powder, whether the drug should be taken before or after a meal (p < 0.001), and the method and volume for syrup measurement (p < 0.001). CONCLUSION: This study demonstrated that when compared to reading a package insert or education sheet, a pharmacist's verbal education with photographic education materials was significantly more effective and time-saving in providing caregivers with the correct knowledge of oral antibiotic suspensions in pediatrics.


Assuntos
Assistência Ambulatorial , Anticorpos/administração & dosagem , Educação de Pacientes como Assunto , Administração Oral , Cuidadores , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Farmacêuticos , Análise de Regressão , Suspensões
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