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1.
J Inflamm Res ; 15: 3409-3420, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35706529

RESUMO

Background: Hypertension is a common complication in injection drug users (IDU), especially a high proportion of resistant hypertension occurs among them. However, the involving mechanisms remain largely unknown. Methods: We here investigated the key signaling moieties in resistant hypertension in drug users. Analyses were performed with high-throughput transcriptomic sequencing data of peripheral blood from individuals with drug-sensitive hypertension (Ctrl-DS), IDU with resistant hypertension (IDU-DR), and IDU with sensitive hypertension (IDU-DS). Results: We showed that 17 and 1 genes in IDU-DS, 48 and 4 genes in IDU-DR were upregulated and downregulated compared Ctrl-DS, and 2 and 4 genes were upregulated and downregulated in IDU-DR compared with IDU-DS, respectively (p ≤ 0.01 and |log2(FC)| ≥ 1). Differentially expressed genes (DEGs) between Ctrl-DS and IDU-DS were mainly involved in Gene ontology terms of immunoglobulin complex and blood microparticle. DEGs between IDU-DS and IDU-DR were mainly involved in immune system process and immunoglobulin complex. DEGs between Ctrl-DS and IDU-DR were mainly involved in immunoglobulin complex, blood microparticle and cytoplasmic vesicle lumen. We identified 2 gene clusters (brown modules, MEbrown; turquoise module, MEturquoise) correlated with IDU-DR and a gene cluster (magenta module, MEmagenta) correlated with IDU-DS by weighted gene co-expression network analysis (WGCNA). Functional analysis demonstrated that pathways of focal adhesion and focalin-1-rich granule lumen were involved in the development of IDU-DR, and the cytosolic large ribosomal subunit may relate to IDU-DR. Further, immune cell infiltration analysis demonstrated that the abundance of dendritic cells (DCs), natural Treg cells (nTreg), and exhausted T cells (Tex) in IDU-DR and IDU-DS, naïve CD8+ T cells in IDU-DS was significantly different compared with that in Ctrl-DS. The abundance of cytotoxic T cells (Tc) was significantly different between IDU-DS and IDU-DR. Conclusion: Our findings indicated a potential function of immunoregulation mechanisms for resistant hypertension.

2.
Front Psychiatry ; 13: 893290, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35733804

RESUMO

Background: This study aimed to investigate how social networks are associated with cognitive function in the middle-aged and elderly Korean population. Methods: A total of 7,704 individuals over the age of 50 were included from the baseline recruitment of the Cardiovascular and Metabolic Diseases Etiology Research Center cohort from the years 2013 to 2018. Egocentric social network characteristics including network size, intimacy, and frequency of face-to-face meetings were measured as exposures, and the Korean version of Mini-Mental State Examination (K-MMSE) score was measured to reflect general cognitive function as an outcome. We also stratified the analysis by income level into tertiles, with income caps of 42,000 thousand won and 72,000 thousand won. A general linear regression model was used, adjusting for age, gender, socioeconomic factors, lifestyle factors, depressive symptoms, and study settings. Results: Social network properties were positively associated with cognitive function in both men and women. However, the specific estimates varied according to gender and income level. In men, frequency was most significantly associated with cognitive function (standardized ß = 0.093, p-value <0 .0001). In women, the strength of the association with cognitive function was found in size (standardized ß = 0.055, p-value = 0.001). The effect modification of income level could be seen in the association between frequency and cognitive function. The strongest association between frequency and cognitive function was found in the middle income group in men (standardized ß = 0.114, p-value = 0.0063), and the low income group in women (standardized ß = 0.076, p-value = 0.0039). Conclusion: There were positive associations between social network properties (i.e., size, intimacy, and frequency of face-to-face meetings) and cognitive function. The degree of association varied according to social network properties, gender, and income level. Overall, among social network properties, social network size was an important factor in the cognition of women, whereas frequency was important in the cognition of men.

3.
Commun Biol ; 5(1): 539, 2022 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-35660788

RESUMO

Ferredoxin-dependent metabolic engineering of electron transfer circuits has been developed to enhance redox efficiency in the field of synthetic biology, e.g., for hydrogen production and for reduction of flavoproteins or NAD(P)+. Here, we present the bioconversion of carbon monoxide (CO) gas to formate via a synthetic CO:formate oxidoreductase (CFOR), designed as an enzyme complex for direct electron transfer between non-interacting CO dehydrogenase and formate dehydrogenase using an electron-transferring Fe-S fusion protein. The CFOR-introduced Thermococcus onnurineus mutant strains showed CO-dependent formate production in vivo and in vitro. The maximum formate production rate from purified CFOR complex and specific formate productivity from the bioreactor were 2.2 ± 0.2 µmol/mg/min and 73.1 ± 29.0 mmol/g-cells/h, respectively. The CO-dependent CO2 reduction/formate production activity of synthetic CFOR was confirmed, indicating that direct electron transfer between two unrelated dehydrogenases was feasible via mediation of the FeS-FeS fusion protein.


Assuntos
Monóxido de Carbono , Thermococcus , Monóxido de Carbono/metabolismo , Formiato Desidrogenases/genética , Formiato Desidrogenases/metabolismo , Formiatos/metabolismo , Hidrogênio/metabolismo , Thermococcus/genética , Thermococcus/metabolismo
4.
Sensors (Basel) ; 22(12)2022 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-35746182

RESUMO

As vehicles provide various services to drivers, research on driver emotion recognition has been expanding. However, current driver emotion datasets are limited by inconsistencies in collected data and inferred emotional state annotations by others. To overcome this limitation, we propose a data collection system that collects multimodal datasets during real-world driving. The proposed system includes a self-reportable HMI application into which a driver directly inputs their current emotion state. Data collection was completed without any accidents for over 122 h of real-world driving using the system, which also considers the minimization of behavioral and cognitive disturbances. To demonstrate the validity of our collected dataset, we also provide case studies for statistical analysis, driver face detection, and personalized driver emotion recognition. The proposed data collection system enables the construction of reliable large-scale datasets on real-world driving and facilitates research on driver emotion recognition. The proposed system is avaliable on GitHub.


Assuntos
Condução de Veículo , Acidentes de Trânsito/prevenção & controle , Condução de Veículo/psicologia , Coleta de Dados , Emoções
5.
Oxid Med Cell Longev ; 2022: 2555476, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35770049

RESUMO

Pulmonary hypertension (PH) is caused by chronic hypoxia that induces the migration and proliferation of pulmonary arterial smooth muscle cells (PASMCs), eventually resulting in right heart failure. PH has been related to aberrant autophagy; however, the hidden mechanisms are still unclear. Approximately 40% East Asians, equivalent to 8% of the universal population, carry a mutation in Aldehyde dehydrogenase 2 (ALDH2), which leads to the aggregation of noxious reactive aldehydes and increases the propensity of several diseases. Therefore, we explored the potential aspect of ALDH2 in autophagy associated with PH. In vitro mechanistic studies were conducted in human PASMCs (HPASMCs) after lentiviral ALDH2 knockdown and treatment with platelet-derived growth factor-BB (PDGF-BB). PH was induced in wild-type (WT) and ALDH2-knockout (ALDH2-/-) mice using vascular endothelial growth factor receptor inhibitor SU5416 under hypoxic conditions (HySU). Right ventricular function was assessed using echocardiography and invasive hemodynamic monitoring. Histological and immunohistochemical analyses were performed to evaluate pulmonary vascular remodeling. EdU, transwell, and wound healing assays were used to evaluate HPASMC migration and proliferation, and electron microscopy and immunohistochemical and immunoblot assays were performed to assess autophagy. The findings demonstrated that ALDH2 deficiency exacerbated right ventricular pressure, hypertrophy, fibrosis, and right heart failure resulting from HySU-induced PH. ALDH2-/- mice exhibited increased pulmonary artery muscularization and 4-hydroxynonenal (4-HNE) levels in lung tissues. ALDH2 knockdown increased PDGF-BB-induced PASMC migration and proliferation and 4-HNE accumulation in vitro. Additionally, ALDH2 deficiency increased the number of autophagosomes and autophagic lysosomes together with autophagic flux and ERK1/2-Beclin-1 activity in lung tissues and PASMCs, indicating enhanced autophagy. In conclusion, the study shows that ALDH2 has a protective role against the migration and proliferation of PASMCs and PH, possibly by regulating autophagy through the ERK1/2-Beclin-1 pathway.


Assuntos
Insuficiência Cardíaca , Hipertensão Pulmonar , Aldeído Desidrogenase/metabolismo , Aldeído-Desidrogenase Mitocondrial/genética , Aldeído-Desidrogenase Mitocondrial/metabolismo , Animais , Autofagia , Becaplermina , Proteína Beclina-1/metabolismo , Proliferação de Células , Células Cultivadas , Insuficiência Cardíaca/metabolismo , Hipertensão Pulmonar/genética , Sistema de Sinalização das MAP Quinases , Camundongos , Miócitos de Músculo Liso/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismo
6.
Artigo em Inglês | MEDLINE | ID: mdl-35711866

RESUMO

Background: ACGME requires all Internal Medicine training programs to structure the curriculum to optimize resident educational experiences, including perioperative medicine. Teaching residents about perioperative risk management is challenging in a community hospital with limited resources and low surgical volume. Objective: Our goal was to introduce an interactive educational module on perioperative cardiac risk assessment and management in a community residency training program. Methods: The study was a single-center online education-based intervention from September 2020 to January 2021. 24 categorical internal medicine residents at MetroWest Medical center were included. A self-paced online education program followed by two sessions of a 30-minute, group modulated review and discussion were provided monthly. The pre- and post-evaluation with 20 questions were conducted to assess perioperative cardiac risk assessment and peri-operative cardiac risk management before and after education. Results: 20 out of 24 residents (83%) were included in the analysis. Medicine residents performed significantly better after involvement with the educational module by comparing the pre- and post-evaluation score (10.7 ± 2.7 vs. 13.8 ± 1.8, p < 0.001, respectively). The most significant improvement was noticed in postgraduate year PGY-1 residents (5.1 ± 2.5, p < 0.001), followed by PGY-2 (2.7 ± 1.6, p = 0.004), but not significant in PGY-3 residents (1.6 ± 2.3, p > 0.05). Conclusion: Implementing an interactive multi-modular curriculum in a community hospital increased residents' awareness and knowledge of perioperative cardiac risk assessment and management. We are confident that this will result in improved performance on the consult services.

7.
Mitochondrial DNA B Resour ; 7(6): 974-976, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35712544

RESUMO

Petrale sole Eopsetta jordani (Pleuronectiformes: Pleuronectidae) is a species of flounder, found in the northeastern Pacific Ocean and the Bering Sea of the United States and Canada. The complete mitochondrial DNA (mtDNA) of E. jordani has 16,483 bp with an overall A + T content of 61% and consists of 2 ribosomal RNA (rRNA) genes, 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, and a non-coding control region. It has incomplete stop codon genes in ND2, COII, ATPase6, COIII, ND3, and ND4. Phylogenetic analysis indicated that E. jordani is not monophyletic with cogeneric Eopsetta grigorjewi and is separated from other species in the same family by a large distance. Present study results provide useful data for further research on genetic diversity and evolution of the Eopsetta and the Pleuronectidae.

8.
J Am Chem Soc ; 2022 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-35766932

RESUMO

Restructuring is ubiquitous in thermocatalysis and of pivotal importance to identify the real active site, yet it is less explored in electrocatalysis. Herein, by using operando X-ray absorption spectroscopy in conjunction with advanced electron microscopy, we reveal the restructuring of the as-synthesized Cu-N4 single-atom site to the nanoparticles of ∼5 nm during the electrochemical reduction of nitrate to ammonia, a green ammonia production route upon combined with the plasma-assisted oxidation of nitrogen. The reduction of Cu2+ to Cu+ and Cu0 and the subsequent aggregation of Cu0 single atoms is found to occur concurrently with the enhancement of the NH3 production rate, both of them are driven by the applied potential switching from 0.00 to -1.00 V versus RHE. The maximum production rate of ammonia reaches 4.5 mg cm-2 h-1 (12.5 molNH3 gCu-1 h-1) with a Faradaic efficiency of 84.7% at -1.00 V versus RHE, outperforming most of the other Cu catalysts reported previously. After electrolysis, the aggregated Cu nanoparticles are reversibly disintegrated into single atoms and then restored to the Cu-N4 structure upon being exposed to an ambient atmosphere, which masks the potential-induced restructuring during the reaction. The synchronous changes of the Cu0 percentage and the ammonia Faradaic efficiency with the applied potential suggests that the Cu nanoparticles are the genuine active sites for nitrate reduction to ammonia, which is corroborated with both the post-deposited Cu NP catalyst and density functional theory calculations.

9.
ACS Appl Mater Interfaces ; 14(25): 28706-28715, 2022 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-35695736

RESUMO

Evaluating the structural and electronic-state characteristics of long-range disordered amorphous iridium (Ir)-based oxides is still unsatisfying. Compared with the benchmark IrO2, the higher oxygen evolution reaction (OER) performance brought by IrOxOHy was normally considered to be associated with the pristine IrIII-containing species. However, such a conclusion conflicts with the opinion that high-valence metals can create excellent OER activity. To resolve such contradictions, we synthesized a pure amorphous Lu1.25IrOxOHy (Lu = lutetium) catalyst in this work. In combination with the comprehensive electrochemical evaluation in alkaline and acidic media, ex situ Ir L3-edge and O K-edge X-ray absorption spectroscopy and theoretical calculations revealed that the ultrahigh OER performance of reconstructed IrOx/Lu1.25IrOxOHy in acidic media was identified to be driven by the more d-hole-containing electronic state of IrV created by cationic vacancies. The pristine properties of IrIII-containing Lu1.25IrOxOHy conversely inhibit the OER activity in alkaline media. Additionally, the high edge-shared [IrOx]-[IrOx] motif proportion structure in amorphous Lu1.25IrOxOHy achieves a stable OER process, which exhibits a high S-number stability index similar to IrO2. We demonstrate that the key factor of the edge-shared [IrOx]-[IrOx] motif with cationic vacancies in IrVOxOHy could rationally reveal the source for most of the high-performance Ir-based materials.

10.
Sensors (Basel) ; 22(11)2022 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-35684625

RESUMO

Wooden utility poles are one of the most commonly used utility carriers in North America. Even though they are given different protection treatments, wooden utility poles are prone to have defects that are mainly caused by temperature, oxygen, moisture, and high potential hydrogen levels after decades of being exposed in open-air areas. In order to meet the growing demand regarding their maintenance and replacement, an effective health evaluation technology for wooden utility poles is essential to ensure normal power supply and safety. However, the commonly used hole-drilling inspection method always causes extra damage to wooden utility poles and the precision of health evaluation highly relies on technician experience at present. Therefore, a non-destructive health evaluation method with frequency-modulated empirical mode decomposition (FM-EMD) and Laplace wavelet correlation filtering based on dynamic responses of wooden utility poles was proposed in this work. Specifically, FM-EMD was used to separate multiple confusing closely-spaced vibration modes due to nonlinear properties of wooden utility poles into several single modes. The instantaneous frequency and damping factor of the decomposed signal of each single mode of the dynamic response of a wooden utility pole could be determined using Laplace wavelet correlation filtering with high precision. The health status of a wooden utility pole could then be estimated according to the extracted instantaneous frequency and damping factor of the decomposed signal of each single mode. The proposed non-destructive health evaluation method for wooden utility poles was tested in the field and achieved successful results.


Assuntos
Algoritmos
11.
Zhongguo Zhen Jiu ; 42(6): 707-11, 2022 Jun 12.
Artigo em Chinês | MEDLINE | ID: mdl-35712960

RESUMO

The systematic reviews (SRs) of acupuncture published before December 31 of 2020 in PubMed, Cochrane and EMbase databases were searched, and the publication overview of international acupuncture SRs were analyzed. As a result, a total of 717 SRs were included, and the overall number of published SRs showed a fluctuating upward trend. A total of 15 categories of diseases were involved, of which 113 SRs suggested that acupuncture was effective, and 12 SRs did not support acupuncture, and the remaining SRs showed uncertain conclusions. It is suggested that the standard of evidence-based medicine should be adopted to standardize the design of acupuncture trial and improve the level of clinical research; SRs should include high-quality literature that met the standards according to the principles and methods of PRISMA, so as to provide reliable clinical evidence for acupuncture.


Assuntos
Terapia por Acupuntura , Acupuntura , Publicações Periódicas como Assunto , Medicina Baseada em Evidências , PubMed
12.
Artigo em Inglês | MEDLINE | ID: mdl-35668258

RESUMO

The all-vanadium redox flow battery (VRFB) is becoming a promising technology for large-scale energy storage due to its advantages such as scalability and flexibility. In recent years, the VRFB has been successfully developed and put into use in many countries. It is expected that the abandoned VRFB will generate a large amount of vanadium waste. To our knowledge, there are few reports on the disposal of spent VRFBs. Herein, chitosan-coated nano-zero-valent iron (CS-Fe0) is proposed for the first time as adsorbents for the treatment of spent VRFBs. It can provide a new approach to deal with the upcoming large number of spent VRFBs. The calculated maximum adsorption capacity for V(V) of chitosan and CS-Fe0 reached 209.5 and 511.3 mg/g at 288 K, respectively. CS-Fe0 showed better adsorption performance than chitosan under different pH conditions and is easy to be separated from the liquid phase. The Freundlich isotherm was suitable for the adsorption process of chitosan, and CS-Fe0 was more consistent with the Langmuir isotherm. Ionic strength (0.05-0.5 M) had a positive effect on the adsorption capacity of CS-Fe0, and the influence of coexisting anions on CS-Fe0 could be negligible. FTIR and XPS analyses revealed that the primary mechanisms were the electrostatic attraction of chitosan and redox of Fe0. The present study confirmed that CS-Fe0 could be a potential material to efficiently trap V(V) from the VRFB electrolyte.

13.
Int J Gen Med ; 15: 5197-5209, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35651674

RESUMO

Purpose: Patients with middle-aged and elderly rectal cancer (MERC) usually have poor prognosis after surgery. This study aimed to develop a nomogram to achieve individualized prediction of overall survival (OS) in patients with MERC and to guide follow-up and subsequent diagnosis and treatment plans. Patients and Methods: A total of 349 patients were randomly assigned to the training and validation cohorts in a 7:3 ratio. Multivariate Cox regression analysis was performed using the results of univariate Cox regression analysis to confirm independent prognostic factors of OS. Thereafter, the nomogram was built using the "rms" package. Subsequently, discriminative ability and calibration of the nomogram were evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Integrated discrimination improvement (IDI), net reclassification improvement (NRI), and the area under the ROC curves (AUC) were compared between the nomogram and the tumor-node-metastasis (TNM) staging system (8th edition). Finally, we established a predictive model to assess the survival benefit of patients with MERC by calculating nomogram scores for each patient. Results: Six variables were identified as independent prognostic factors and included in the nomogram: smoking history, family history, hematochezia, tumor size, N stage, and M stage. Based on these factors, we successfully constructed a nomogram and evaluated its discriminative and predictive abilities using ROC curves, calibration curves, and DCA. ROC curves, IDI, and NRI showed that the nomogram had outstanding clinical utility compared with the TNM staging system (8th edition) for OS prediction. The predictive model successfully distinguished between high-, medium-, and low-risk MERC patients. Conclusion: Our nomogram provided a more satisfactory survival prediction ability than the TNM staging system (8th edition) for MERC patients. In addition, the nomogram was able to accurately categorize patients into different risk groups after surgery.

14.
Huan Jing Ke Xue ; 43(6): 3241-3252, 2022 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-35686794

RESUMO

To clarify the distribution characteristics and the ecological stoichiometric characteristics of nutrient elements in soils under different vegetation types, four typical natural wetlands, i.e., Phragmites australis wetland, Tamarix chinensis wetland, Suaeda salsa wetland, and Tidal flat wetland, as well as Gossypium spp. fields that were reclaimed from natural wetlands, were selected as study sites in the Yellow River Delta, and comparisons between the agricultural reclamation land and natural wetlands were conducted. The results showed that the soil total organic carbon (TOC) and total nitrogen (TN) contents in the natural wetlands were as follows:P. australis wetland and T. chinensis wetland>S. salsa wetland>Tidal flat, and the contents of TOC and TN were significantly negatively related to electrical conductivity (EC) and pH values (P<0.05). The contents of TOC, TN, and total phosphorus (TP) in Gossypium spp. fields were significantly higher than those in natural wetlands (P<0.05), especially the contents of nitrate nitrogen (NO3--N) in Gossypium spp. fields, which were 9.4-11.4 times that of natural wetlands. However, no significant correlations between TOC, TN, and TP and EC and pH values (P>0.05) were observed in Gossypium spp. fields. The results of correlation analysis showed that the C/N of natural wetlands were mainly controlled by the contents of TN (P<0.05), and the C/N of the Gossypium spp. fields were significantly lower than those of natural wetlands (P<0.05). The soil C/P and N/P of natural wetlands and Gossypium spp. fields in the Yellow River Delta were low, and the variation trends were consistent with those of soil TOC and TN. Comparative analysis revealed, on the whole, that there were significantly different soil nutrient element contents, C/N, C/P, and N/P in Gossypium spp. fields compared to those of natural wetlands (P<0.05). The process of reclamation could significantly change the spatial distribution of nutrient elements in wetlands. Our results should be of importance in revealing the biogeochemical process of soil nutrient elements in coastal wetland and the influence of agricultural reclamation activities on the differentiation of soil nutrient elements.


Assuntos
Solo , Áreas Alagadas , Carbono/análise , China , Nitrogênio/análise , Nutrientes/análise , Fósforo/análise , Rios/química , Solo/química
15.
Front Microbiol ; 13: 885413, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35663872

RESUMO

Processes in the food industry that use large amounts of water have been an important cause of waterborne disease outbreaks, as they expose individuals to risks for waterborne disease transmission. Developing technologies to ensure the hygiene and safety of food-processing steps is an urgent concern from an economic perspective. Furthermore, economic benefits can be derived if the processed water can be reused under microbiologically safe conditions. Among the major manufacturing processes in the kimchi industry, the brining process for salted kimchi cabbages requires a considerable amount of brine (approximately 2,000-2,500 l/1,000 kg of raw cabbage). The aim of this study was to establish virucidal conditions with ultraviolet-C light-emitting diodes (UVC LEDs) that can ensure the microbiological safety of brine water samples with various turbidities for reuse after disinfection. For quantitative analysis, first of all, magnetic bead separation (MBS) technique was used to capture and recover the human norovirus (HuNoV) virus particles; propidium monoazide (PMA) combined with RT-qPCR (PMA-RT-qPCR) was subsequently used to selectively detect infectious norovirus. Overall, as the turbidity of the brine water samples increased, the reduction in the HuNoV genogroup II genotype 4 (HuNoV GII.4) levels by UVC LED disinfection decreased. The derived inactivation rate constant (kinac ) and inactivation curves (calculated using the log-linear model) were studied as a function of turbidity based on the exponential one-phase inactivation kinetics of HuNoV. Using an impeller system set at 100 rotations/min (rpm) with an eight-nephelometric turbidity unit (NTU) sample (the lowest turbidity studied), the kinact based on the levels of viral genomic RNA concentrations was approximately 2.15-fold higher than that observed without rotation (0 rpm). Moreover, the kinact increased 1.69-fold with a 56-NTU sample (the highest turbidity studied) when the impeller system was set at 100 rpm. UVC LED treatment decreased the HuNoV GII.4 population more effectively in conjunction with the impeller system (100 rpm) than without the impeller system. Our novel findings and model provide fundamental and scientific data that may help reuse brine water and ensure its microbiological safety through disinfection. Our study highlights the benefits of UVC LED treatment in successfully eliminating waterborne viruses in a prompt, resistance-reducing, and energy-efficient approach at the laboratory scale, which lays the foundation for future plant-scale studies of UVC LED-disinfection systems.

16.
Environ Anal Health Toxicol ; 37(1): e2022005-0, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35500888

RESUMO

In this study, 16 children's products with the highest detection potential of phthalates were selected, and a phthalate assay and transdermal delivery analysis (NIER, US EPA Wipe [stress condition], US EPA Wipe [physiological condition], and US EPA Hand Wipe) were conducted with these products. The content of 6 controlled phthalates (DBP, BBP, DEHP, DNOP, DINP, and DIDP) was measured and most products contained more phthalates than the regulated guidelines (a total content of 6 phthalates to be ≤0.1%). For transdermal delivery, all items were found to be lower in the NIER transdermal delivery test method compared to the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method. For the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method, a similar result was observed, except for DINP. The average daily dose (ADD) estimated by determining the exposure algorithm for each transdermal delivery test method was highest in mats with a large contacting surface area and a long exposure time in the respective test methods. Conclusively, there was a difference between the NIER transdermal delivery test method and the US EPA Wipe transdermal delivery test method.

17.
Artigo em Inglês | MEDLINE | ID: mdl-35576034

RESUMO

Activated carbon was one of the main adsorptions utilized in elemental mercury (Hg0) removal from coal combustion flue gas. However, the high cost and low physical adsorption efficiency of activated carbon injection (ACI) limited its application. In this study, an ultra-high efficiency (nearly 100%) catalyst sorbent-Sex/Activated carbon (Sex/AC) was synthesized and applied to remove Hg0 in the simulated flue gas, which exhibited 120 times outstanding adsorption performance versus the conventional activated carbon. The Sex/AC reached 17.98 mg/g Hg0 adsorption capacity at 160 °C under the pure nitrogen atmosphere. Moreover, it maintained an excellent mercury adsorption tolerance, reaching the efficiency of Hg0 removal above 85% at the NO and SO2 conditions in a bench-scale fixed-bed reactor. Characterized by the multiple methods, including BET, XRD, XPS, kinetic and thermodynamic analysis, and the DFT calculation, we demonstrated that the ultrahigh mercury removal performance originated from the activated Se species in Sex/AC. Chemical adsorption plays a dominant role in Hg0 removal: Selenium anchored on the surface of AC would capture Hg0 in the flue gas to form an extremely stable substance-HgSe, avoiding subsequent Hg0 released. Additionally, the oxygen-containing functional groups in AC and the higher BET areas promote the conversion of Hg0 to HgO. This work provided a novel and highly efficient carbon-based sorbent -Sex/AC to capture the mercury in coal combustion flue gas. Graphical abstract Selenium-modified porous activated carbon and the interface functional group promotes the synergistic effect of physical adsorption and chemical adsorption to promote the adsorption capacity of Hg0.

18.
Mitochondrial DNA B Resour ; 7(5): 861-863, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35602332

RESUMO

Eopsetta grigorjewi (Pleuronectiformes: Pleuronectidae) is a demersal flatfish found in South Korea, Japan, Taiwan, China, and the Yellow Sea. E. grigorjewi complete mitochondrion DNA (mtDNA) consists of 16,921 bp and a 54% A + T content. It includes 2 ribosomal RNA (rRNA), 22 transfer RNA (tRNA), 13 protein-coding genes, and 1 non-coding regulatory area. ND2, ND3, ND4, COII, COIII, ATPase6, and CytB all have incomplete stop codon genes. The evolutionary analysis of 13 species from the same family indicated a close relationship. This work will be valuable for future research on molecular evolution and the creation of biomarker databases for determining the originality of E. grigorjewi.

19.
Zhongguo Zhen Jiu ; 42(5): 585-9, 2022 May 12.
Artigo em Chinês | MEDLINE | ID: mdl-35543954

RESUMO

To explore the influencing factors of acupuncture curative effect in literature of experts' experience. The journal literature of experts' experience was retrieved from China National Knowledge Infrastructure (CNKI) and PubMed, starting from inception to September 4, 2020, and the influencing factors of acupuncture curative effect were extracted and analyzed. A total of 499 articles were included, involving 495 articles in Chinese and 4 articles in English. The influencing factors of acupuncture curative effect mainly include five aspects: diagnostic method, acupoint selection of acupuncture, acupuncture manipulation, regulating mind of acupuncture and acupuncture time, and provide reference for acupuncture protocol design in clinical trials.


Assuntos
Terapia por Acupuntura , Acupuntura , Pontos de Acupuntura , Terapia por Acupuntura/métodos , PubMed , Publicações
20.
World J Gastroenterol ; 28(15): 1526-1535, 2022 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-35582132

RESUMO

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field. Patients with COVID-19 usually have respiratory symptoms. However, liver dysfunction is not an uncommon presentation. Additionally, the degree of liver dysfunction is associated with the severity and prognosis of COVID-19. Prevention, diagnosis, and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19, especially in those with liver dysfunction. Recently, a large number of studies have reported that nutrition therapy measures, including natural dietary supplements, vitamins, minerals and trace elements, and probiotics, might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant, antiviral, anti-inflammatory, and positive immunomodulatory effects. This review mainly focuses on the possible relationship between COVID-19 and liver dysfunction, nutritional and metabolic characteristics, nutritional status assessment, and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.


Assuntos
COVID-19 , Hepatopatias , Nutricionistas , Humanos , Hepatopatias/diagnóstico , Hepatopatias/terapia , Pandemias , SARS-CoV-2
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