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1.
BMC Cancer ; 20(1): 176, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32131772

RESUMO

BACKGROUND: The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esophageal carcinoma (SEC) remains unclear. METHODS: We searched Embase, PubMed, Web of Science, and Cochrane Library databases for prospective articles to better understand the relationship between LVI, LNM, and SEC diagnosis. RESULTS: We included 23 articles containing data for 4749 patients (range: 54-598) in our meta-analysis. The hazard ratio between LVI and overall survival (OS) was 1.85 with 95% confidence interval (CI) (1.10-3.11, P = 0.02). LNM rate was higher in SEC patients with LVI than SEC patients without LVI (univariate: OR = 4.94, 95% CI: 3.74-6.53, P < 0.0001; multivariate: OR = 5.72, 95%CI: 4.38-7.4, P < 0.0001). No obvious publication was found. CONCLUSIONS: The results indicate that LVI plays a dominant role in the prognosis of LNM in SEC and in the prognostic prediction for SEC.

2.
Artigo em Inglês | MEDLINE | ID: mdl-30754664

RESUMO

Climate variability has been documented as being key to influencing human wellbeing across cities as it is linked to mortality and illness due to changes in the perceived weather cycle. Many studies have investigated the impact of summer temperature on human health and have proposed mitigation strategies for summer heat waves. However, sub-tropical cities are still experiencing winter temperature variations. Increasing winter perceived temperature through the decades may soon affect city wellbeing, due to a larger temperature change between normal winter days and extreme cold events, which may cause higher health risk due to lack of adaptation and self-preparedness. Therefore, winter perceived temperature should also be considered and integrated in urban sustainable planning. This study has integrated the increasing winter perceived temperature as a factor for developing spatiotemporal protocols for mitigating the adverse impact of climate change. Land surface temperature (LST) derived from satellite images and building data extracted from aerial photographs were used to simulate the adjusted wind chill equivalent temperature (AWCET) particularly for sub-tropical scenarios between 1990 and 2010 of the Kowloon Peninsula, Hong Kong. Compared with perceived temperature based on the representative station located at the headquarters of the Hong Kong Observatory, the temperature of half the study area in the Kowloon Peninsula has raised by 1.5 °C. The areas with less green space and less public open space in 2010 show higher relative temperatures. Socioeconomically deprived areas (e.g., areas with lower median monthly income) may suffer more from this scenario, but not all types of socioeconomic disparities are associated with poor sustainable planning. Based on our results and the "no-one left behind" guideline from the United Nations, climate change mitigation should be conducted by targeting socioeconomic neighborhoods more than just aging communities.


Assuntos
Planejamento de Cidades , Mudança Climática , Temperatura Alta , Estações do Ano , Tempo (Meteorologia) , Aclimatação , Cidades , Demografia , Hong Kong , Humanos , Vento
3.
Int Orthop ; 43(3): 573-577, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-29911277

RESUMO

AIM: To investigate the incidence, risk factors, and the last follow-up recovery status of sciatic and femoral nerve injury among patients who received Bernese peri-acetabular osteotomy (PAO). PATIENTS AND METHODS: The clinical file of 643 consecutive patients who received PAO from June 2012 to June 2016 was retrospectively reviewed. The number of nerve injury patients was calculated and the causes of injury were recorded. RESULTS: The sciatic or femoral nerve injury occurred in eight patients (1.24%), including four sciatic nerve injuries and four femoral nerve injuries. The reasons for sciatic nerve injury included one direct sciatic nerve injury happened at the time when deep osteotomy penetrated the posterior column to cut the nerve trunk at the area where the nerve runs through out of the greater sciatic foramen during quadrilateral bone osteotomy. The other two direct sciatic nerve injuries occurred at the inside pelvis by long drill bit or Kirschner wire drilling before the transverse screw fixation. No direct injury reasons could be found for the remaining five patients with one partial sciatic nerve injury and four femoral nerve palsies. The three patients with direct sciatic nerve injuries were partly recovered at the last follow-up. Full recovery was found in one sciatic nerve injury and four femoral nerve injury patients. CONCLUSION: The sciatic nerve can be injured directly or indirectly during PAO. It is of great importance to understand the risk factors and the precautionary measures of nerve injuries during PAO.

4.
Biomed Res Int ; 2018: 9064073, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30364052

RESUMO

CD4+CD25+Foxp3+ Tregs control the immune response and maintain immune homeostasis. This study examined whether Tregs can affect mouse enteritis and the Foxp3 (Forkhead transcription factor) transcriptional pathway. Mouse CD4+CD25+ Treg cells were labelled using CFSE (5,6-carboxyfluorescein diacetate succinimidyl ester) and transferred to enteritis model mice. The mice were randomly divided into an enteritis group, a Treg-infusion group, a Treg-inhibiting group, and a control group. Histopathology, ELISA, flow cytometry, western blot, immunohistochemistry, and immunofluorescence were performed. Our results demonstrated that CD4+CD25+ Tregs were successfully transferred. The disease activity index (DAI) scores in the Tregs-infusion group were lower than those of the enteritis and Tregs-inhibiting groups. The number of goblet cells and inflammatory cells was reduced, and the levels of IL-1ß, TNF-α, NO, and PGE2 were significantly decreased in the Tregs-infusion group compared to those in the enteritis group (p<0.05). The number of CD4+CD25+Foxp3+ Tregs and CD4+IL-17A+ Th17 cells in the mesenteric lymph nodes differed significantly from the enteritis and Tregs-inhibiting groups (p<0.05). There were more Foxp3+ Tregs and Smad3 and NFAT2 infiltrated into the duodenum after adoptive transfer of CD4+CD25+ Tregs, which was a significant difference relative to the enteritis group (p<0.05). This study demonstrated that adoptive transfer of CD4+CD25+ Tregs can decrease mouse enteritis. Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.


Assuntos
Transferência Adotiva , Enterite/terapia , Fatores de Transcrição Forkhead/imunologia , Regulação da Expressão Gênica/imunologia , Transdução de Sinais/imunologia , Linfócitos T Reguladores/transplante , Animais , Modelos Animais de Doenças , Enterite/imunologia , Enterite/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Fatores de Transcrição NFATC/imunologia , Proteína Smad3/imunologia , Linfócitos T Reguladores/imunologia , Linfócitos T Reguladores/patologia , Células Th17/imunologia , Células Th17/patologia
5.
Food Funct ; 9(5): 2942-2950, 2018 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-29741189

RESUMO

Extraction of nutrients from plants is an important unit operation in the food and biological industries. The target nutrient is usually spatially distributed throughout the plant tissue. The intact cell wall and adhering membranes are the main resistances to molecular diffusion. Therefore, disintegration of the intact structure, which in turn increases the permeability of adhering membranes, can significantly improve the nutrient extraction yield and efficiency. In this study, different physical treatments (homogenization, high pressure homogenization, and ball mill grinding) were applied to investigate their effects on the tissue microstructure and the release of vitamin C. The changes in the microstructure were reflected by LF-NMR based on T2 distribution, particle size distribution, and microscopy images. The extraction yield of vitamin C obtained by high-pressure homogenization was increased by 75.69% for floret and 28.84% for stalk, respectively, as compared to that obtained by mechanical homogenization. The degradation of vitamin C was significant due to prolonged operation of the ball mill grinding method although the integrity of the tissues was similar to that of the high-pressure homogenization-treated tissues. This study confirms that the degree of tissue disintegration has a positive correlation with the release of the nutrient (vitamin C) within a limited operating time. LF-NMR has been proven to be an effective method to study the impact of different physical treatments on the cellular structure integrity of plant-originated food materials.


Assuntos
Ácido Ascórbico/química , Brassica/química , Espectroscopia de Ressonância Magnética/métodos , Extratos Vegetais/química , Ácido Ascórbico/isolamento & purificação , Manipulação de Alimentos , Espectroscopia de Ressonância Magnética/instrumentação , Extratos Vegetais/isolamento & purificação
6.
Exp Ther Med ; 15(4): 3495-3500, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29545874

RESUMO

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11, a member of the transforming growth factor-ß superfamily, has been reported to be involved in colorectal cancer. However, the roles of GDF11 in Chinese patients with liver cancer and the underlying mechanisms have remained elusive. The present study assessed the expression of GDF11 in 10 paired samples of cancerous and normal tissues from Chinese liver cancer patients. The results indicated that the expression of GDF11 was significantly lower in cancerous tissues than in normal tissues. In vitro, the expression of GDF11 was reduced in a panel of liver cancer cell lines compared with that in a normal liver cell line at the mRNA and protein level. Treatment with GDF11 reduced the viability of HepG2 for up to 72 h and GDF11 treatment reduced the viability of SMMC-7721 after 48 and 72 h. Furthermore, GDF11 activated Smad2/3 signaling in HepG2 cells. In conclusion, GDF11 has a tumor suppressor role in liver cancer, exerts its effects through Smad2/3 signaling and may serve as a novel tumor marker in liver cancer diagnosis.

7.
Polymers (Basel) ; 10(4)2018 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-30966407

RESUMO

In order to explore the immediate effect of polysaccharides and macrophages, polysaccharides from masson pine pollen (PPM60) were labeled with fluorescein isothiocyanate (FITC) by using a chemical-derived method, and the reactant was named PPM60-Tyr-FITC. Direct interaction of PPM60-Tyr-FITC and RAW264.7 macrophages could be detected by flow cytometer (FCM), and this interaction could be inhibited by Pitstop 2 (clathrin inhibitor) and TAK-242 (Toll-like receptor 4 inhibitor). The results of confocal laser scanning microscopy (CLSM) also revealed that there was a co-localization phenomenon between PPM60-Tyr-FITC and RAW264.7 macrophage receptors, and it could be suppressed by Pitstop 2 and TAK-242. It was confirmed that PPM60 enters into RAW264.7 macrophages mainly through endocytosis, rather than the phagocytosis, and TLR4 played a mediating role.

8.
Environ Int ; 112: 10-22, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29245038

RESUMO

Haze is an extreme weather event that can severely increase air pollution exposure, resulting in higher burdens on human health. Few studies have explored the health effects of haze, and none have investigated the spatiotemporal interaction between temperature, air quality and urban environment that may exacerbate the adverse health effects of haze. We investigated the spatiotemporal pattern of haze effects and explored the additional effects of temperature, air pollution and urban environment on the short-term mortality risk during hazy days. We applied a Poisson regression model to daily mortality data from 2007 through 2014, to analyze the short-term mortality risk during haze events in Hong Kong. We evaluated the adverse effect on five types of cause-specific mortality after four types of haze event. We also analyzed the additional effect contributed by the spatial variability of urban environment on each type of cause-specific mortality during a specific haze event. A regular hazy day (lag 0) has higher all-cause mortality risk than a day without haze (odds ratio: 1.029 [1.009, 1.049]). We have also observed high mortality risks associated with mental disorders and diseases of the nervous system during hazy days. In addition, extreme weather and air quality contributed to haze-related mortality, while cold weather and higher ground-level ozone had stronger influences on mortality risk. Areas with a high-density environment, lower vegetation, higher anthropogenic heat, and higher PM2.5 featured stronger effects of haze on mortality than the others. A combined influence of haze, extreme weather/air quality, and urban environment can result in extremely high mortality due to mental/behavioral disorders or diseases of the nervous system. In conclusion, we developed a data-driven technique to analyze the effects of haze on mortality. Our results target the specific dates and areas with higher mortality during haze events, which can be used for development of health warning protocols/systems.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar , Smog , Saúde da População Urbana/estatística & dados numéricos , Poluição do Ar/análise , Poluição do Ar/estatística & dados numéricos , Hong Kong , Humanos , Distribuição de Poisson , Análise Espaço-Temporal , Temperatura Ambiente
9.
Int J Health Geogr ; 16(1): 26, 2017 07 24.
Artigo em Inglês | MEDLINE | ID: mdl-28738805

RESUMO

BACKGROUND: Dust events have long been recognized to be associated with a higher mortality risk. However, no study has investigated how prolonged dust events affect the spatial variability of mortality across districts in a downwind city. METHODS: In this study, we applied a spatial regression approach to estimate the district-level mortality during two extreme dust events in Hong Kong. We compared spatial and non-spatial models to evaluate the ability of each regression to estimate mortality. We also compared prolonged dust events with non-dust events to determine the influences of community factors on mortality across the city. RESULTS: The density of a built environment (estimated by the sky view factor) had positive association with excess mortality in each district, while socioeconomic deprivation contributed by lower income and lower education induced higher mortality impact in each territory planning unit during a prolonged dust event. Based on the model comparison, spatial error modelling with the 1st order of queen contiguity consistently outperformed other models. The high-risk areas with higher increase in mortality were located in an urban high-density environment with higher socioeconomic deprivation. CONCLUSION: Our model design shows the ability to predict spatial variability of mortality risk during an extreme weather event that is not able to be estimated based on traditional time-series analysis or ecological studies. Our spatial protocol can be used for public health surveillance, sustainable planning and disaster preparation when relevant data are available.


Assuntos
Poluição do Ar/análise , Cidades/epidemiologia , Poeira/análise , Mapeamento Geográfico , Mortalidade/tendências , Regressão Espacial , Idoso , Idoso de 80 Anos ou mais , Monitoramento Ambiental/métodos , Feminino , Hong Kong/epidemiologia , Humanos , Masculino , Fatores Socioeconômicos , Fatores de Tempo
10.
J Chem Phys ; 144(2): 024308, 2016 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-26772572

RESUMO

Ro-vibrational term values of the 3(1)Σg (+) state of (85,85)Rb2 and (85,87)Rb2 and resolved fluorescence spectra to the A(1)Σu (+) state are recorded following optical-optical double resonance excitation. The experimental data are heavily perturbed, and as a result, the standard analysis based on Dunham series representation of the energy levels fails. The analysis is done via modeling the adiabatic potential function with the Rydberg-Klein-Rees potential constructed from the generalized smoothing spline interpolation of the vibrational energies Gv and rotational constants Bv.

11.
J Chem Phys ; 143(12): 124307, 2015 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-26429011

RESUMO

New ro-vibrational structures of cold Cs2 in the 0u(+) state near the asymptote 6S1/2 + 6P1/2 are resolved. The variation of the rotational constants shows that the related energy spectra are strongly perturbed. An analysis of new data along with the empirical and theoretical information available from other sources is performed. For this purpose the model of spin-orbit coupling of the Hund's case (a) states A(1)Σu(+)∼b(3)Πu proposed by Bai et al. [Phys. Rev. A 83, 032514 (2011)] is extrapolated to the dissociation limit, and the parameters of the extrapolation are fitted from the near-dissociation experimental data.

12.
J Am Acad Dermatol ; 73(6): 991-7.e3, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26416303

RESUMO

BACKGROUND: The efficacy of methotrexate (MTX) varies in the treatment of psoriasis. OBJECTIVE: We sought to identify an indicator from routine pretreatment tests to predict MTX efficacy in the treatment of psoriasis. METHODS: In a retrospective analysis of 77 psoriatic patients, the correlation between MTX efficacy and pretreatment routine test results was analyzed with Spearman correlation. The potential risks were further evaluated with a linear regression model. Receiver operating characteristic analysis was performed to examine the effectiveness of serum total calcium (tCa) to predict the effect of MTX on psoriasis. The highest Youden index was used to determine the cutoff point, with which the positive and negative predictive values were calculated. Synergistic effects of MTX and calcium on keratinocyte growth and psoriasis-like mouse model were also investigated. RESULTS: The pretreatment tCa level exhibited the closest association with MTX efficacy. The relative psoriasis improvement with tCa was 61.07% (95% confidence interval, 42.85-79.29; P < .001) and better improvements were observed in patients with higher tCa (r = 0.588; P < .002). MTX inhibited keratinocyte growth, which was enhanced synergistically by calcium. In a psoriasis-like mouse model, MTX strongly inhibited epidermis proliferation in the high-calcium group. LIMITATIONS: One limitation of our study is the relatively small sample size. CONCLUSION: Pretreatment tCa level has the highest correlation with MTX efficacy, which might be useful in predicting beneficial treatment results in psoriasis. Larger studies are required to confirm our findings.


Assuntos
Cálcio/sangue , Metotrexato/administração & dosagem , Psoríase/sangue , Psoríase/tratamento farmacológico , Adolescente , Adulto , Idoso , Animais , Área Sob a Curva , Biomarcadores/sangue , Estudos de Coortes , Modelos Animais de Doenças , Feminino , Humanos , Masculino , Camundongos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Psoríase/patologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto Jovem
13.
J Chem Phys ; 141(24): 244310, 2014 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-25554154

RESUMO

We report on new observations of the photoassociation spectroscopy of ultracold cesium molecules using a highly sensitive detection technique and a combined analysis with all observed electronic states. The technique is achieved by directly modulating the frequency of the trapping lasers of a magneto-optical trap. New observations of the Cs2 0g(-), 0u(+), and 1g states at the asymptotes 6S1/2 + 6P1/2 and 6S1/2 + 6P3/2 are reported. The spectral range is extended to the red detuning of 112 cm(-1) below the 6S1/2 + 6P3/2 dissociation limit. Dozens of vibrational levels of the ultracold Cs2 0g(-), 0u(+), and 1g states are observed for the first time. The available experimental binding energies of these states are analyzed simultaneously in a framework of the generalized LeRoy-Bernstein theory and the almost degenerate perturbation theory by Marinescu and Dalgarno [Phys. Rev. A: At., Mol., Opt. Phys. 52, 311 (1995)]. The unique atomic-related parameter c3 governing the dispersion forces of all the molecular states is estimated as (10.29 ± 0.05) a.u.

14.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 5): o1366, 2012 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-22590260

RESUMO

The crystal structure of the title compound, C(12)H(11)NO(2), represents a new ortho-rhom-bic polymorph II of the previously reported ortho-rhom-bic form I [Zhang et al. (2009 ▶) Acta Cryst. E65, o3160]. In polymorph II, the six-membered rings form a dihedral angle of 13.8 (1)° [71.6 (1)° in I], and O-H⋯N hydrogen bonds link mol-ecules into chains along [100], whereas the crystal structure of I features hydrogen-bonded centrosymmetric dimers.

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