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1.
Gene ; 764: 145105, 2021 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-32882333

RESUMO

Sarcoma (SARC) represents a group of highly histological and molecular heterogeneous rare malignant tumors with poor prognosis. There are few proposed classifiers for predicting patient's outcome. The Cancer Proteome Atlas (TPCA) and The Cancer Genome Atlas (TCGA) databases provide multi-omics datasets that enable a comprehensive investigation for this disease. The proteomic expression profile of SARC patients along with the clinical information was downloaded. 55 proteins were found to be associated with overall survival (OS) of patients using univariate Cox regression analysis. We developed a prognostic risk signature that comprises seven proteins (AMPKALPHA, CHK1, S6, ARID1A, RBM15, ACETYLATUBULINLYS40, and MSH6) with robust predictive performance using multivariate Cox stepwise regression analysis. Additionally, the signature could be an independent prognostic predictor after adjusting for clinicopathological parameters. Patients in high-risk group also have worse progression free intervals (PFI) than that of patients in low-risk group, but not for disease free intervals (DFI). The signature was validated using transcriptomic profile of SARC patients from TCGA. Potential mechanisms between high- and low-risk groups were identified using differentially expressed genes (DEGs) analysis. These DEGs were primarily enriched in RAS and MPAK signaling pathways. The signature protein molecules are candidate biomarkers for SARC, and the analysis of computational biology in tumor infiltrating lymphocytes and immune checkpoint molecules revealed distinctly immune landscapes of high- and low-risk patients. Together, we constructed a prognostic signature for predicting outcomes for SARC integrating proteomic and transcriptomic profiles, this might have value in guiding clinical practice.

2.
Talanta ; 221: 121477, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-33076090

RESUMO

Due to the potential threats of phosgene and nitrite to public health and safety, in this work, we first proposed the application of a facile dual-function fluorescent probe 2-(1H-Benzimidazol-2-yl)Aniline (BMA) for the detection of phosgene and nitrite in different solvent environments. BMA had fast response (1 min), high selectivity and sensitivity (the limit of detection was 1.27 nM) to phosgene in CH3CN solution (containing 10% DMSO), which manifested as a ratiometric fluorescent mode from 416 nm to 480 nm. The response of BMA to nitrite in HCl solution (pH = 1, containing 10% CH3CN) was also highly selective and sensitive (the limit of detection was 60.63 nM), which shown as a turn-off fluorescent mode at 485 nm. In addition, two portable chemosensors (BMA-loaded TLC plates and test strips) had also been successfully manufactured for the detection of phosgene in the gas phase and nitrite in solution, which displayed good responses. Most importantly, BMA had also been successfully used for detection of nitrite in food samples, and a good recovery (88.5%-107.2%) was obtained by adding standard sodium nitrite.

3.
Nanoscale ; 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33026377

RESUMO

Searching for new-type, eco-friendly, and Earth-abundant thermoelectric materials, which can be used as an alternative to the high-cost bismuth telluride, is important for near-room-temperature applications. In this work, nanostructured monoclinic Cu2Se with a low carrier concentration has been synthesized by a wet mechanical alloying process combined with spark plasma sintering. Such a low carrier concentration, which originates from the effectively suppressed Cu deficiencies during the fabrication process, induces a relatively low electrical conductivity and carrier thermal conductivity. Besides, the nanostructured grains combined with point defects and phonon resonance enhance the phonon scattering to induce a low lattice thermal conductivity without sacrificing the electrical transport properties. As a result, our nanostructured monoclinic Cu2Se obtains a figure of merit of 0.72 at 380 K with good thermal stability. This work indicates that nanostructured monoclinic Cu2Se is a promising near-room-temperature thermoelectric material.

4.
Artigo em Inglês | MEDLINE | ID: mdl-33015742

RESUMO

An integrated process to increase the yield of incomplete degradation products of galactomannan (GalM) especially for galactomanno-oligosaccharides (GalMOS) was suggested. Trichoderma reesei employed Avicel or GalMOS as a carbon source to produce ß-mannanase or α-galactosidase independently, with a result of 3.78 ± 0.12 U/mL of ß-mannanase activity and 2.45 ± 0.06 U/mL of α-galactosidase activity which were obtained, respectively. GalM in Sesbania seed was hydrolyzed simultaneously by a mixture of crude enzyme with ß-mannanase and α-galactosidase at a dosage of 20 U/g GalM and 15 U/g GalM, respectively; the yields of incomplete degradation products of GalM (IDP-GalM) and GalMOS were 78.84% ± 3.14% and 30.94% ± 0.38%, respectively, which was beneficial to improve the biological activity of the incomplete degradation products. The role of α-galactosidase addition in mixture enzymes is to remove the galactose substituents from mannan backbone of GalM and alleviate the steric hindrance of ß-mannanase hydrolysis.

5.
Epigenetics ; : 1-16, 2020 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-33016206

RESUMO

Cardiac remodelling is widely accepted as a common characteristic for many heart diseases, especially in heart failure (HF). Ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are associated with cardiac remodelling. Both mRNA and microRNA are potential diagnostic markers and therapeutic targets of cardiac remodelling in HF. However, the mechanisms of microRNA-mRNA joint regulation in HF are still unclear. In this study, 3 gene expression profiles from patients with and without HF were analysed to harvest shared differentially expressed genes (microRNA and mRNA) with significant major biological function. Moreover, key genes highly related to ICM and DCM-induced HF were screened out through a Weighted Genes Co-Expression Network Analysis (WGCNA). Based on microRNA-mRNA analysis, several microRNAs and target genes were identified. Combined with pathway analysis, we found that miR-542-3p and its target gene CILP were likely involved in the regulation of TGF-ß signalling pathway in ICM induced HF. Collectively, the microRNA-mRNA interaction network analysis revealed that miR-542-3p-CILP as mediator of TGF-ß signalling pathway might be a new mechanism to mediate ICM induced HF. This study provides certain novel targets for diagnosis and therapeutic treatment of ICM- and DCM-induced HF.

6.
Nucleic Acids Res ; 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33045727

RESUMO

The COVID-19 outbreak has become a global emergency since December 2019. Analysis of SARS-CoV-2 sequences can uncover single nucleotide variants (SNVs) and corresponding evolution patterns. The Global Evaluation of SARS-CoV-2/hCoV-19 Sequences (GESS, https://wan-bioinfo.shinyapps.io/GESS/) is a resource to provide comprehensive analysis results based on tens of thousands of high-coverage and high-quality SARS-CoV-2 complete genomes. The database allows user to browse, search and download SNVs at any individual or multiple SARS-CoV-2 genomic positions, or within a chosen genomic region or protein, or in certain country/area of interest. GESS reveals geographical distributions of SNVs around the world and across the states of USA, while exhibiting time-dependent patterns for SNV occurrences which reflect development of SARS-CoV-2 genomes. For each month, the top 100 SNVs that were firstly identified world-widely can be retrieved. GESS also explores SNVs occurring simultaneously with specific SNVs of user's interests. Furthermore, the database can be of great help to calibrate mutation rates and identify conserved genome regions. Taken together, GESS is a powerful resource and tool to monitor SARS-CoV-2 migration and evolution according to featured genomic variations. It provides potential directive information for prevalence prediction, related public health policy making, and vaccine designs.

7.
World Neurosurg ; 2020 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-33065351

RESUMO

This paper discusses the clinical value of standardized early pregnancy ultrasound structure screening in the diagnosis of fetal central nervous system malformations. In this paper, 6902 cases (8336 fetuses) of 11~13+6 weeks of gestation (5468 cases of singleton pregnancy and 1434 cases of twin pregnancy) underwent standardized early pregnancy ultrasound structure screening, and tracked the pregnancy process and clinical outcome. The results found that 13 cases of central nervous system malformations (10 cases of single pregnancy, 3 cases of twin pregnancy) were detected by prenatal ultrasound in 6902 cases (8336 fetuses) 11~13+6 weeks of gestation, including 5 cases of exposed brain malformations, none There were 4 cases of cerebral children, 2 cases of forebrain without splitting, 1 case of meningocele, and 1 case of open spina bifida. There were 4 cases with other structural abnormalities and 3 cases with abnormal karyotype. Follow-up results of 13 fetuses: Except for 3 cases of twin malformed fetuses who continued to be pregnant after selective reduction, the ultrasound results of the remaining fetuses were consistent with the autopsy results after the induction of labor. For this reason, it can be concluded that standardized ultrasound structural screening during early pregnancy can detect fetal central nervous system malformations early, and has important clinical value in reducing the birth rate of malformed fetuses and guiding obstetric treatment.

8.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(10): 1131-1134, 2020 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-33059813

RESUMO

A boy, aged 6 months, had the manifestations of intellectual and motor developmental delay, head instability, general weakness, unawareness of grasping objects by hands, and unusual facies (slightly wide eye distance, epicanthus, esotropia, mouth-opening appearance, short philtrum, and low-set ears). Gene detection results showed a de novo heterozygous frameshift mutation of the CHAMP1 gene at the chromosomal location of chr13:115089847, and nuclear acid was changed to c.530delCinsTTT, resulting in a change in amino acid to p.S177Ffs*2. Therefore, the boy was diagnosed with autosomal dominant intellectual disability-40 caused by the mutation in the CHAMP1 gene. This case report suggests that for children with unexplained intellectual disability, especially those with generalized hypotonia and severe language disorder, the possibility of CHAMP1 gene mutation should be considered, and genetic testing should be performed as early as possible.

9.
Oxid Med Cell Longev ; 2020: 9102012, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33062149

RESUMO

The widespread use of therapeutic glucocorticoids has increased the frequency of glucocorticoid-induced osteoporosis (GIOP). One of the potential pathological processes of GIOP is an increased level of oxidative stress and mitochondrial dysfunction, which eventually leads to osteoblast apoptosis. Proanthocyanidins (PAC) are plant-derived antioxidants that have therapeutic potential against GIOP. In our study, a low dose of PAC was nontoxic to healthy osteoblasts and restored osteogenic function in dexamethasone- (Dex-) treated osteoblasts by suppressing oxidative stress, mitochondrial dysfunction, and apoptosis. Mechanistically, PAC neutralized Dex-induced damage in the osteoblasts by activating the Nrf2 pathway, since silencing Nrf2 partly eliminated the protective effects of PAC. Furthermore, PAC injection restored bone mass and promoted the expression of Nrf2 in the distal femur of Dex-treated osteoporotic rats. In summary, PAC protect osteoblasts against Dex-induced oxidative stress and mitochondrial dysfunction via the Nrf2 pathway activation and may be a promising drug for treating GIOP.

10.
Neurochem Res ; 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33063244

RESUMO

With millions of traumatic brain injury (TBI) patients every year, TBI is regarded as one of the leading causes of human death and disability. Calcitonin gene-related peptide (CGRP) has been domenstrated to be a potential therapeutic target for TBI. However, the detailed effect and underlying mechanism of CGRP on the injured brain after TBI has hardly been investigated. In this work, we established TBI models of mice and injected CGRP before and after modelling to study its effects on the brain lesion, neurological functions and behaviours, neuron apoptosis and autophagy after TBI. Impacts of introduced CGRP on the activation of Akt/mTOR signalling in the cortical tissues surrounding injured areas after TBI were also evaluated. It was found that CGRP was reduced after TBI, and gradually restored over time. CGRP administration significantly restored the brain lesion induced by TBI. The permeability of blood-brain barrier and brain edema was increased dramatically after TBI, which was ameliorated by exogenous CGRP. Moreover, several neurological behaviour tests were performed, showing that CGRP introduction also relieved the cognitive abilities of mice which were impaired after TBI. Enhancing apoptosis and autophagy of neurons in the cortical tissues of injury sites following TBI were also alleviated by CGRP administration. Besides, CGRP-treated brain cortical tissues showed increased activation of Akt/mTOR signalling after TBI. Therefore, the results suggest that exogenous CGRP plays a neuroprotective role in the injuryed brain after TBI, to relieve cell apoptosis and autophagy, at least partially through Akt/mTOR signalling pathway. This finding also provides more evidence for the treatment of TBI through introducing exogenous CGRP or its related drugs.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33025280

RESUMO

PURPOSE: Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) can be associated with hemophagocytic lymphohistiocytosis (NK/T-LAHLH), which is a rare and fatal disease with no effective therapy. We evaluated whether etoposide + dexamethasone-based chemotherapy regimens might be useful for treating NK/T-LAHLH. METHODS: This retrospective single-center study evaluated clinical data from 37 patients with NK/T-LAHLH who were treated between May 2008 and January 2020. RESULTS: Among 363 patients with ENKTL, the cumulative incidence of HLH was 11.9%. Among 43 patients with NK/T-LAHLH, 37 patients received etoposide + dexamethasone-based chemotherapy regimens, with an overall response rate of 45.9% for the HLH. The overall response rate was substantially higher for newly diagnosed NK/T-LAHLH than it was for relapsed or refractory NK/T-LAHLH (66.7% vs. 18.8%). The median overall follow-up time was 4 months, with overall survival rates of 81.1% at 1 month, 62.2% at 2 months, 56.8% at 3 months, and 34.4% at 6 months. Significantly better overall survival (all P < 0.05) was observed for patients with newly diagnosed NK/T-LAHLH (vs. relapsed/refractory disease), stage I/II disease (vs. stage III/IV disease), and nasal disease (vs. non-nasal disease). Patients who responded to the ENKTL treatment also experienced response in their HLH; 8 patients experienced continued complete response for both HLH and ENKTL. Multivariate analysis revealed that a poor prognosis among patients with NK/T-LAHLH was independently related to relapsed/refractory ENKTL and non-nasal disease. CONCLUSION: Although patients with NK/T-LAHLH generally experienced poor outcomes, etoposide + dexamethasone-based chemotherapy regimens were associated with good outcomes among select patients with newly diagnosed or stage I/II NK/T-LAHLH.

12.
Medicine (Baltimore) ; 99(41): e22633, 2020 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-33031323

RESUMO

RATIONALE: Leiomyomatosis peritonealis disseminata (LPD) is a rare benign lesion primarily consisting of smooth muscle cells, which mostly affects premenopausal females. Here, we reported 3 females with LPD (age, 40-48 years) admitted for pelvic masses. PATIENT CONCERNS: All 3 LPD cases received laparoscopic uterine fibroid morcellation at 3, 8, and 14 years ago, respectively. Two cases were admitted for pelvic masses. One case was admitted for recurrent fibroids with pollakiuria. DIAGNOSES: LPD was considered in 2 cases preoperation according to imaging examination, and one of them received ultrasound-guided biopsy of the lesion in the right lobe of the liver. One case was considered as recurrent fibroids preoperation. After surgery, all cases were pathologically diagnosed as LPD consisting of benign smooth muscle cells. INTERVENTIONS: A total abdominal hysterectomy, salpingo-oophorectomy, and debulking was performed for all 3 cases. Intraoperative exploration revealed that the fibroids distributed in the mesentery (3 cases), broad ligament (1 case), omentum (1 case), liver (1 case), and rectus abdominis (1 case). OUTCOMES: No recurrence was found during postoperative following-up (5-12 months). LESIONS: Preoperative diagnosis of LPD is presented as a challenge due to unspecific clinical manifestations. Its diagnosis mainly depends on histopathologic evaluation. Surgery still is the primary treatment for LPD. For patients without reproductive desire, total abdominal hysterectomy, salpingo-oophorectomy, and debulking can be performed, and the affected tissue should be removed as much as possible based on the risk assessment.

13.
J Mater Chem B ; 8(38): 8781-8793, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33026383

RESUMO

Oral cancer is a common malignant life-threatening tumor. Despite some advances in traditional therapy, mortality and mobidity rates are high due to delayed diagnosis and ineffective treatment. Additionally, some patients inevitably suffer from various fatal adverse effects during the course of therapy. Therefore, it is imperative to develop novel methods to eradicate oral cancer cells with minimal adverse effects on normal cells. Nanotechnology is a promising and novel vehicle for the diagnosis and treatment of oral cancer with encouraging recent achievements. In this review, we present state-of-the-art nanotechnology-based drug delivery systems employed in the domain of oral cancer, especially for its enhanced diagnosis and therapy. We describe in detail the types of nanotechnology used in the management of oral cancer and summarize administration routes of nanodrugs. Finally, the potential and prospects of nanotechnology-based drug delivery systems as promising modalities of diagnosis and therapy of oral cancer are highlighted.

14.
Carbohydr Polym ; 250: 116951, 2020 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-33049893

RESUMO

A novel method for the quantitative characterization of incomplete degradation products of galactomannan (IDPG) was developed by ethanol fractional precipitation. In this work, IDPG in the enzymatic hydrolyzate of Sesbania cannabina galactomannan was fractionated into several fractions with high recovery (>96 %) by ethanol fractional precipitation. The average molecular weights of obtained fractions were in descending order with varied corresponding contents of galactomannan degradation products. Thus, the quantitative characterization of IDPG can be achieved. Moreover, the results of statistical validation and method robustness showed that the method has good reproducibility. Surprisingly, when this method was applied to the guar gum or locust bean gum enzymatic hydrolyzates, it was found that the lower the mannose to galactose ratio of un-hydrolyzed galactomannan, the higher the molecular weight of their degradation product obtained under same ethanol concentration. This method is effectively applied to the quantitative characterization of IDPG from other sources.

15.
Sci Rep ; 10(1): 17305, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33057140

RESUMO

p-Alkoxyphenols (AOPs) are a class of ethers that are widely used in industrial and agricultural productions and daily necessities. p-Phenoxyphenol (PhOP) and p-pentyloxyphenol (PeOP) belong to this class and have been reported to be estrogenic in vitro. However, their in vivo estrogenic activities have rarely been of concern. In this study, we performed an immature mouse uterotrophic assay and studied the estrogenic effects of these two compounds in mice. The results revealed that the uterine weights of the animals treated with PhOP significantly increased at doses of 30 and 300 mg kg-1 bw day-1 for 3 days (P < 0.05), while no significant uterotrophic effects were observed in the mice treated with PeOP. Using next-generation transcriptome sequencing (RNA-seq), we also analyzed the gene expression in the uterine tissue of mice treated with PhOP and PeOP. The observed gene regulation patterns of the PhOP- and PeOP-treated specimens were similar to those of the 17ß-estradiol (E2)-treated specimens. In particular, some estrogen-responsive genes, such as the Sprr2 gene family, Apoa1, Prap1, and Ahsg, displayed a regulation trend similar to that of E2. In addition, molecule docking analysis revealed that both PhOP and PeOP could be well docked into the active site of hERα, with potential of mean force (PMF) values of - 58.68 and - 52.67 kcal mol-1 for PhOP and PeOP, respectively. The results of this study indicate that PhOP exhibits relatively strong in vivo estrogenic activity, which could be of future concern.

16.
Artigo em Inglês | MEDLINE | ID: mdl-33052612

RESUMO

BACKGROUND: The COVID-19 pandemic has powerfully shaped people's lives. The current work investigated the emotional and behavioral reactions people experience in response to COVID-19 through their internet searches. We hypothesised that when the prevalence rates of COVID-19 increase, people would experience more fear, which in turn would predict more searches for protective behaviors, health-related knowledge, and panic buying. METHODS: Prevalence rates of COVID-19 in the United States, the United Kingdom, Canada, and Australia were used as predictors. Fear-related emotions, protective behaviors, seeking health-related knowledge, and panic buying were measured using internet search volumes in Google Trends. RESULTS: We found that increased prevalence rates of COVID-19 were associated with more searches for protective behaviors, health knowledge, and panic buying. This pattern was consistent across four countries, the United States, the United Kingdom, Canada, and Australia. Fear-related emotions explained the associations between COVID-19 and the content of their internet searches. CONCLUSIONS: Findings suggest that exposure to COVID-19 prevalence and fear-related emotions may motivate people to search for relevant health-related information so as to protect themselves from the pandemic.

17.
J Med Case Rep ; 14(1): 185, 2020 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-33046131

RESUMO

BACKGROUND: The incidence of angioimmunoblastic T-cell lymphoma is rare worldwide, and it has a poor prognosis. There is no proven or standard first-line therapy that works for the majority of patients with angioimmunoblastic T-cell lymphoma because of the rarity of this disease. The treatment and management are challenging for clinicians. CASE PRESENTATION: This report presents the diagnosis and treatment of a 65-year-old Chinese man who presented with cough and lymph node swellings in the left axillary region. The patient was diagnosed with angioimmunoblastic T-cell lymphoma. He underwent eight cycles of chemotherapy with CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone) followed by TOMO radiotherapy (helical tomotherapy, a kind of radiotherapy for cancer treatment using spiral computed tomographic scanning). After treatment, the therapeutic effects were evaluated by magnetic resonance imaging and computed tomography about every 3 months. The patient recovered well with no sign of tumor recurrence and no obvious severe treatment-related adverse effects. CONCLUSION: This treatment experience indicates an essential role for the combination of radiation therapy with CHOP, which may have a better prognosis than treatments without radiation therapy. But challenges warrant further validation in prospective studies.

18.
Life Sci ; 263: 118572, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33065147

RESUMO

AIM: Apoptosis of endothelial cells (ECs) is a crucial factor in blood-spinal cord barrier (BSCB) disruption post spinal cord injury (SCI). Insulin-like growth factor-1 (IGF-1) is a protective cytokine that plays an important role in multiple diseases, whereas the distinct role in SCI-induced remains critical questions to address. Here we designed to explore the role and underlying mechanism of IGF-1 in endothelial damage after SCI. MAIN METHODS: In the current study, we established mouse microvascular endothelial cells (MVECs) injury model via LPS and cDNA of IGF-1 was transfected into MVECs. In vivo SCI mice, overexpression of IGF-1 (SCI-IGF-1) and its corresponding empty vehicle (SCI-NC) were conducted using lentivirus, then apoptosis degree, component of tight junction, and inflammatory damage were evaluated. KEY FINDINGS: IGF-1 treatment in MVECs displayed a milder apoptosis and cell damage under LPS insult. IGF-1 increased the level of PI3K/AKT pathway, which impeded the procedure of apoptosis. Blocking of PI3K/AKT pathway markedly neutralized the effect of IGF-1 treatment. Transfection of excess IGF-1 into SCI mice significantly corrected microenvironment of neural tissue repair, reduced area of injured core and improved functional recovery with greater activation of PI3K/AKT pathway. SIGNIFICANCE: The results above argue that the promising roles played by IGF-1 is potentially vital for developing effective future therapies in SCI.

19.
Spectrochim Acta A Mol Biomol Spectrosc ; 246: 119044, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33068898

RESUMO

Terahertz (THz) waves have unique advantages in detecting biological substances. However, due to the strong absorption of THz waves by water, the development of THz detection technology in this field is seriously restricted. At present, although there are a few methods to detect hydrated materials, they cannot be widely used because of their defects. In this paper, a convenient and promising method for the detection of THz spectra of hydrated substances is proposed. A horn shaped tapered parallel plate waveguide is designed, which can enhance the electrical field of the incident THz wave at its central position, so as to obtain the THz spectral information of hydrated substances in a THz time-domain spectroscopy system. The detection of α-lactose dilute solution was demonstrated, the spectral range is from 0.1 to 1.5 THz and the sensitivity can reach the order of femtomole. This method has potential application prospect in the in situ detection of trace hydrated substances, cells and biomolecules.

20.
Inorg Chem ; 2020 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-33040527

RESUMO

Zn-doped cuprous oxide (Cu2O) nanoparticles coated by carbon layers (Zn/Cu2O@C) have been obtained via a bimetallic MOF (Zn/Cu-MOF-199) as the sacrificial precursor. Originated from the octahedral morphology of Zn/Cu-MOF-199, the as-synthesized Zn/Cu2O@C shows a porous octahedron structure. The obtained Zn/Cu2O@C can afford the following merits. (1) The cation doping of Zn inside Cu2O can enhance the light absorption by introducing impurity energy levels and facilitate the separation of photoinduced electrons and holes. (2) The coating of a carbon layer in Zn/Cu2O@C can also efficiently enhance the separation efficiency of photoinduced charge carriers. (3) The porous structure of Zn/Cu2O@C can provide increased active sites. Therefore, these merits lead to the highly improved photocatalytic activities toward various chemical reactions. In addition, the fully coated carbon layer can facilitate the cycle stability of Zn/Cu2O@C in the photocatalytic processes.

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