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Artigo em Chinês | MEDLINE | ID: mdl-33794624


Objective:To assess and compare therapeutic effects and quality of life after endoscopic and microscopic myringoplasty using Chinese version of the Zurich chronic middle ear inventory(ZCMEI). Methods:Patients with chronic suppurative otitis media underwent myringoplasty at the Third Hospital of Peking University from October 2018 to September 2019 were included in this study and divided into two groups: endoscopic tympanoplasty group(n=40) and microscopic tympanoplasty group(n=57). ZCMEI survey and pure tone audiometry were conducted preoperatively and 3-9 months postoperatively. The operation time, intraoperative blood loss, length of hospital, graft success rate, complication rate, hearing improvement and quality of life improvement were compared. Results:①The operation time, length of hospital and intraoperative blood loss of endoscopic group were significantly lower(P<0.05). ②The graft success rate was 92.5% and 98.2%, respectively(P>0.05). The difference between the complication rate in two groups was not significant, but patients in endoscopic group had no symptoms of wound numbness or pain. ③Air conduction threshold(AC) and air-bone gap(ABG) were significantly lower after surgery in endoscopic group(n=33) and microscopic group(n=43). The analyzed result of generalized linear model indicated surgical approach had no influence on postoperative AC and ABG(P>0.05). ④The total scores of ZCMEI were significantly improved in endoscopic group(n=32) and microscopic group(n=48) postoperatively, as well as the scores of ear symptoms, hearing and psychosocial impact(P<0.05). Preoperative and postoperative scores of medical resources were not significantly different in either groups(P>0.05). Controlling the course of disease, the total ZCMEI results and scores of each subscale in patients with single ear involved(n=71) had no significant difference between two groups. Conclusion:Endoscopic myringoplasty has the advantages of minimal invasiveness, short operation time, and quick recovery evaluated from subjective and objective aspects. Audiometry improvement, graft success rate, complication rate and quality of life improvements are comparable between endoscopic tympanoplasty and conventional microscopic tympanoplasty. The assessment of the quality of life is of great significance in efficacy evaluation of otitis media. Doctors should comprehensively consider patient's subjective experience and the objective improvement to obtain the best clinical efficacy.

Miringoplastia , Qualidade de Vida , China , Doença Crônica , Orelha Média , Humanos , Estudos Retrospectivos , Resultado do Tratamento , Timpanoplastia
Artigo em Inglês | MEDLINE | ID: mdl-33035679


Myocardin (MYOCD) plays an important role in cardiovascular disease. However, its underlying impact on atherosclerosis remains to be elucidated. ATP binding cassette transporter A1 (ABCA1), a key membrane-associated lipid transporter which maintains intracellular lipid homeostasis, has a protective function in atherosclerosis progress. The purpose of this study was to investigate whether and how the effect of MYOCD on atherosclerosis is associated with ABCA1 in vascular smooth muscle cells (VSMCs). We found both MYOCD and ABCA1 expression were dramatically decreased in atherosclerotic patient aortas compared to control. MYOCD knockdown inhibited ABCA1 expression in human aortic vascular smooth muscle cells (HAVSMCs), leading to reduced cholesterol efflux and increased intracellular cholesterol contents. MYOCD overexpression exerted the opposite effect. Mechanistically, MYOCD regulates ABCA1 expression in an SRF-dependent manner. Consistently, apolipoprotein E-deficient mice treated with MYOCD shRNA developed more plaques in the aortic sinus, which is associated with reduced ABCA1 expression, increased cholesterol retention in the aorta, and decreased high-density lipoprotein cholesterol levels in the plasma. Our data suggest that MYOCD deficiency exacerbates atherosclerosis by downregulating ABCA1 dependent cholesterol efflux from VSMCs, thereby providing a novel strategy for the therapeutic treatment of atherosclerotic cardiovascular disease.

Transportador 1 de Cassete de Ligação de ATP/metabolismo , Aterosclerose/metabolismo , Metabolismo dos Lipídeos , Músculo Liso Vascular/metabolismo , Proteínas Nucleares/metabolismo , Transativadores/metabolismo , Transportador 1 de Cassete de Ligação de ATP/genética , Idoso , Idoso de 80 Anos ou mais , Animais , Aorta/citologia , Aorta/metabolismo , Aorta/patologia , Aterosclerose/genética , Aterosclerose/patologia , Células Cultivadas , Regulação para Baixo , Feminino , Humanos , Masculino , Camundongos Knockout para ApoE , Pessoa de Meia-Idade , Músculo Liso Vascular/citologia , Músculo Liso Vascular/patologia , Proteínas Nucleares/genética , Transativadores/genética
Health Qual Life Outcomes ; 18(1): 218, 2020 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-32641044


BACKGROUND: The demand for assessing health-related quality of life (HRQoL) in chronic otitis media (COM) is increasing globally. The currently available Chinese-language patient-reported outcome measurement (PROM) specific for COM includes merely a limited range of related symptoms and dimensions. Hence, in this study, we aim to translate, culturally adapt, and validate the Zurich Chronic Middle Ear Inventory (ZCMEI-21) in Chinese, to enable a comprehensive evaluation of the patients' subjective health outcome in COM. METHODS: We sampled and surveyed 223 COM patients at three tertiary referral centers in China, using the Chinese translation of ZCMEI-21 (ZCMEI-21-Chn) and the EQ-5D questionnaire, a generic measure of HRQoL. Confirmatory factor analysis (CFA) was performed to investigate the structural model fit to the dataset. Cronbach's α and test-retest reliability coefficient were calculated to establish reliability, and correlation was tested between ZCMEI-Chn scores and EQ-5D scores for convergent validity. RESULTS: A total of 208 adult patients with COM were included, with a mean age of 46 years (SD 14 years) and a male proportion of 41% (85/208). A modified bifactor model with ωH of 0.65 and ECV of 0.47 was found to fit the scale scores, indicating fair general factor saturation and multidimensionality of the instrument. ZCMEI-21-Chn demonstrated good reliability (Cronbach's α = 0.88, test-retest reliability = 0.88). The total scores of ZCMEI-21-Chn had a moderate correlation with a question directly addressing HRQoL (r = 0.40, p < 0.001), EQ-5D descriptive system score (r = 0.57, p < 0.001), and EQ-5D visual analogous scale (r = 0.30, p < 0.001). CONCLUSIONS: The ZCMEI-21-Chn is valid, reliable and culturally adapted to Chinese adult patients with COM. This study offers clinicians an efficient and comprehensive instrument to quantify COM patients' self-reported health outcomes, which could facilitate the standardization of HRQoL data aggregation in COM on a global scale.

Grupo com Ancestrais do Continente Asiático/psicologia , Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , Doença Crônica/psicologia , Autoavaliação Diagnóstica , Otite Média/psicologia , Medidas de Resultados Relatados pelo Paciente , Qualidade de Vida/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Psicometria/métodos , Reprodutibilidade dos Testes , Inquéritos e Questionários , Traduções
Nano Lett ; 20(2): 1110-1116, 2020 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-31891269


Light-weight ceramic aerogels hold promise for superinsulation. However, its mechanical instability and complex manufacturing hampered its technical applications. In this study, we demonstrate lightweight pore-gradient ceramic aerogel-like foam monoliths (PGAFoams) through one-pot and in situ bubble supported pore gradient formation. The mechanically strong PGAFoams exhibit a low thermal conductivity of 0.036 W m-1 K-1 and a compressive strength of 89.85 MPa. The pore gradient and integral ceramic monolith nature provides such hydrophobic PGAFoams with thermal management, robust soundproof, and fire-resistance performance. Highly machinable PGAFoams can be adapted into a variety of shapes and dimensions to accommodate complex geometry applications. The scalable manufacturing of lightweight PGAFoams opens up building insulation with remarkable thermal management, high mechanical strength, low mass density, superior soundproofing, and fire-retardant performances.

Chem Commun (Camb) ; 55(84): 12643-12646, 2019 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-31580340


The charge transfer and spin coupling effects are explored at the interface of two-dimensional (2D) superconducting FeSe nanosheets and molecular photochromic potassium-7,7,8,8-tetracyanoquinodimethane (KTCNQ). Light-induced conductivity in 2D FeSe nanosheets is enhanced by the electron doping from KTCNQ by the destabilized spin-Peierls phase through their interface. Furthermore, the spin coupling at the interface of FeSe and KTCNQ shifts the dimerization transition temperature of KTCNQ. Our results suggest 2D exfoliated FeSe nanosheets as a versatile strongly correlated platform for the study of interfacial electron doping and spin coupling.