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1.
Neural Plast ; 2020: 8842110, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33299396

RESUMO

Musculoskeletal pain (MSP) is one of the most severe complaints in women undergoing menopause. The prevalence of MSP varied when taking the menopausal state and age factor into consideration. This study investigated the prevalence of MSP in perimenopausal women and its association with menopausal state. The MEDLINE, Embase, Web of Science, and PubMed databases were searched from inception to July 2020, and 16 studies were retrieved for the current meta-analysis. The primary outcome measure was the MSP Odds Ratio (OR). The estimated overall prevalence of MSP among perimenopausal women was 71% (4144 out of 5836, 95% confidence interval (CI): 64%-78%). Perimenopausal women demonstrated a higher risk for MSP than premenopausal ones (OR: 1.63, 95% CI: 1.35-1.96, P = 0.008, I 2 = 59.7%), but similar to that in postmenopausal ones (OR: 1.07, 95% CI: 0.95-1.20, P = 0.316, I 2 = 13.4%). The postmenopausal women were at a higher risk of moderate/severe MSP than the premenopausal ones (OR: 1.45, 95% CI: 1.21-1.75, P = 0.302, I 2 = 16.5%) or the perimenopausal ones (OR: 1.40, 95% CI: 1.09-1.79, P = 0.106, I 2 = 55.4%). In conclusion, the perimenopause is a state during which women are particularly predisposed to develop MSP. As to moderate to severe degrees of MSP, the odds increase linearly with age, from premenopause to peri- and then to postmenopause.

2.
Biomed Res Int ; 2020: 5043583, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32685495

RESUMO

Lumbar spinal stenosis (LSS) is a common disease in the elderly population; it has been reported that patients with LSS have an abnormal gait pattern due to symptom such as neurogenic intermittent claudication (NIC); however, no detailed reports exist on the plantar pressure distributions in LSS patients with NIC. To analysis the plantar pressure characteristics of LSS patients, the Footscan® pressure system was used to perform dynamic plantar pressure measurements in 20 LSS patients (age, 69.5 ± 7.2 years) before and after the occurrence of NIC. The contact time (CT), foot progression angle (FPA), pressure-time integral (PTI), and contact area (CA) were collected and compared between the LSS patients and age-matched healthy subjects in each measurement. The LSS group showed an increase in forefoot CT%, PTI, and CA% in both measurements compared with those in the control group. After the occurrence of NIC in the LSS group, CT%, PTI, and CA% of the forefoot increased further compared with those before the occurrence of NIC. In addition, after the occurrence of NIC, the PTI and CA% of the forefoot shifted from the medial foot to the lateral foot. The results suggested that the plantar pressure distributions of patients with LSS differs from normal subjects due to the posture of waking with lumbar forward flexion, and the forefoot bears a higher relative load. In addition, the occurrence of NIC could affect the plantar pressure distribution of the patients with LSS, predicting the patient's risk of falling to the anterior direction and to the symptomatic side.

3.
Orthop Surg ; 12(3): 734-740, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32293800

RESUMO

OBJECTIVE: To investigate the efficiency of anterior decompression on the proximal-type cervical spondylotic amyotrophy patients. METHODS: This was a retrospective analysis. From January 2014 to November 2017, 21 patients with proximal-type cervical spondylotic amyotrophy (CSA) underwent anterior decompression. There were 15 males and 6 females, aged 35-73 years with an average of 51.62 years. All the patients underwent surgery of anterior decompression (ACDF or ACCF). Among them, 12 patients underwent C4/5 single level ACDF, eight patients underwent C4/5 and C5/6 double level ACDF, and one patient underwent C5 anterior cervical corpectomy decompression and fusion surgery. Preoperative and postoperative clinical and radiologic parameters were assessed. The clinical examinations were reviewed, including muscle strength, neck disability index (NDI) score, cervical Japanese Orthopaedic Association (JOA) score, and improvement rate of manual muscle test (MMT) at the last follow-up. Preoperative spinal cord or nerve impingement was assessed by magnetic resonance imaging (MRI) or computed tomography (CT) myelography. Postoperative lateral X-ray radiographs were performed every 3 months after the surgery. RESULTS: Severe preoperative muscle atrophy of the deltoid or biceps muscles occurred in 21 patients included in the study. All of them involve impingements of the ventral nerve root and/or the anterior horn according to MRI and CT myelography. The preoperative duration of symptoms averaged 8.4 months. The average follow-up for all patients was 13.2 months. At the final follow-up, all patients showed statistically significant improvements in muscle strength and NDI scores (P < 0.05, P < 0.05). For the deltoid muscles force and C-JOA scores, the average improvement rates were 66.49% ± 10.04% and 62.23% ± 9.23%, respectively. With respect to MMT, 12 proximal-type patients were graded excellent, six were good, and three were fair, and the overall improvement rate was 85.7%. CONCLUSIONS: For proximal-type CSA patients with cervical radiculopathy, earlier anterior decompression surgery can achieve satisfactory results by significantly improving a patient's muscle strength and relieving compression symptoms.

4.
Biomed Mater ; 15(5): 055013, 2020 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-32252046

RESUMO

Osteoporotic bone defects are a major challenge in clinics for bone regeneration. With the condition of osteoporosis, excessive bone absorption and impaired osteogenesis result in unexpectedly long healing procedures for defects. In order to simultaneously enhance bone formation and reduce bone resorption, a polydopamine-coated porous titanium scaffold was designed, to be integrated with anti-catabolic drug zoledronic acid nanoparticles (ZOL loaded gelatin NPs), which was able to achieve a local sustained release of ZOL as expected. The in vitro study demonstrated that extracts of the composite scaffolds would stimulate osteoblast differentiation; they also inhibited osteoclastogenesis at a ZOL loading concentration of 50 µmol l-1. In the subsequent in vivo study, the composite scaffolds were implanted into ovariectomy-induced osteoporotic rabbits suffering from femoral condyles defects. The results indicated that the composite scaffolds without ZOL loaded gelatin NPs only induced callus formation, mainly at the interface margin between the implant and bone, whereas the composite scaffolds with ZOL loaded gelatin NPs were capable of further enhancing osteogenesis and bone growth into the scaffolds. Moreover, the research proved that the promoting effect was optimal at a ZOL loading concentration of 50 µmol l-1. In summary, the present research indicated that a new type of porous titanium scaffold integrated with ZOL loaded gelatin NPs inherited a superior biocompatibility and bone regeneration capability. It would be an optimal alternative for the reconstruction of osteoporosis-related defects compared to a traditional porous titanium implant; in other words, the new type of scaffold offers a new effective and practical procedure option for patients suffering from osteoporotic bone defects.

5.
Med Sci Monit ; 25: 7370-7375, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31571675

RESUMO

BACKGROUND Many clinical studies have assessed the association of laminoplasty opening size (LOS) with sagittal canal diameter (SCD) based on single-door cervical laminoplasty (SDCL). Nevertheless, the "worn-off" lamina extracted in SDCL was neglected in these reports. We aimed to develop a simple mathematical model to analyze the relationship between the effective LOS and SCD, taking into consideration the worn-off lamina. MATERIAL AND METHODS A total of 106 patients treated by SDCL at our hospital were included in this study. Pre-operative and post-operative SCDs were assessed using a picture archiving and communication system (PACS) based on computed tomography scans. Mini-plate sizes as well as drill bit diameters were recorded in detail in order to determine the effective LOS for each vertebral lamina involved. RESULTS SCD in all patients was increased significantly after SDCL (P<0.01). A linear correlation was found between effective LOS and the post-operative SCD increment from C3 to C7 (R²>0.933, P<0.001). The 12 mm mini-plate was most often used in SDCL, accounting for 64.45% of all cases, whereas 10 mm and 16 mm mini-plates were the least used, accounting for 3.85% and 3.00%, respectively. CONCLUSIONS There is a strong linear correlation between effective LOS and the post-operative SCD increment. The SCD was increased by about 0.5 mm per mm increase in effective LOS. Thus, post-operative SCD could be precisely calculated and predicted, enabling the selection of optimal mini-plate prior to SDCL.


Assuntos
Vértebras Cervicais/cirurgia , Laminectomia/métodos , Laminoplastia/métodos , Placas Ósseas , China , Humanos , Modelos Teóricos , Canal Vertebral/cirurgia , Estenose Espinal/cirurgia
6.
Eur Spine J ; 28(10): 2302-2310, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31053937

RESUMO

PURPOSE: To build a mathematical model which could calculate the desired laminoplasty opening size (LOS) based on the target sagittal canal diameter (SCD) before single-door cervical laminoplasty (SDCL) when taking the effects of surgery drill into consideration. METHODS: The model was based on geometric analysis on deformation of spinal canal; the formula was derived and characterized as: y (mm) = 2 [Formula: see text] × sin(ß/2) = c - d (y is the size of LOS, [Formula: see text] the size of transverse canal diameter, ß the size of laminoplasty opening size, c the size of mini-plate and d the diameter of the drill bit used during the surgery operation). The parameters of pre- and postoperative computed tomography scans of 20 patients who had undergone SDCL were measured by the picture archiving and communication system (PACS) software and a new instrument named as Lei's ruler, respectively. RESULTS: The effects of surgery SDCL were very significant; for each patient, the SCD was enlarged dramatically after the surgery (P < 0.01). The differences between the data obtained by PACS and Lei's ruler were no statistically significant (P > 0.05). According to the derived formula, the 95% confidence intervals of SCD after the surgery were within the range of 14 mm and 14.5 mm. CONCLUSION: Applying the mathematical model and derived formula, the desired LOS could be calculated according to the target SCD which could help the surgeon select an optimum mini-plate before SDCL. At the same time, a new measuring device named Lei's ruler is designed for the convenience of the derived formula. These slides can be retrieved under Electronic Supplementary Material.


Assuntos
Vértebras Cervicais/cirurgia , Laminoplastia/métodos , Modelos Teóricos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
7.
Med Sci Monit ; 24: 7438-7443, 2018 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-30334549

RESUMO

BACKGROUND The incidence of hip fracture is steadily increasing. We aimed to establish a creative approach to precisely estimate the risk of hip fracture by exploring the relationship between hip fracture and bone mineral density (BMD)/femur geometry. MATERIAL AND METHODS Sixteen samples of cadaveric female proximal femora were randomly selected. Experiments were performed experimental measurement of the femoral neck BMD and geometric parameters (including neck length, neck diameter, head diameter, and neck-shaft angle). In addition, the experimental measurements contain the failure load, which represents the mechanical strength of the femoral neck, and we calculated the correlation coefficient among BMD, geometric parameters, and failure load. RESULTS Significant correlations were discovered between femoral mechanical properties and femoral neck BMD (r=0.792, r²=0.628, P<0.001), trochanteric BMD (r=0.749, r²=0.560, P=0.001), and head diameter (r=0.706, r²=0.499, P=0.002). Multiple linear regression analyses indicated that the best predictor of hip fracture was the combination of femoral neck BMD, head diameter, and neck diameter (r²=0.844, P<0.001). CONCLUSIONS The results confirmed that, compared with BMD alone, the combination of BMD and geometric parameters of proximal femur is a better estimation of hip fracture. The geometry of the proximal femur played an important role in assessing the biomechanical strength of femur. This method greatly assists in predicting the risk of hip fracture in clinical trials and will assist studies on why the incidence of hip fracture varies among races.


Assuntos
Fêmur/anatomia & histologia , Fraturas do Quadril/etiologia , Fraturas do Quadril/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Grupo com Ancestrais do Continente Asiático , Densidade Óssea/fisiologia , Cadáver , China , Feminino , Fêmur/fisiologia , Colo do Fêmur/anatomia & histologia , Colo do Fêmur/fisiologia , Humanos , Masculino , Osteoporose Pós-Menopausa , Ossos Pélvicos , Fatores de Risco
8.
Biochimie ; 152: 31-42, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29705132

RESUMO

A high failure rate of titanium implants in diabetic patients has been indicated in clinical evidences. Excessive oxidative stress at the bone-implant interface plays an important role in the impaired osteointegration under diabetic conditions. While the underlying mechanisms remain unknown and the targeted treatments are urgently needed. Ophiopogonin D (OP-D), isolated from Chinese herbal Radix Ophiopogon japonicus, is generally reported to be a potent antioxidant agent. In the present study, we hypothesized that OP-D exerted promotive effects on osteointegration against oxidative stress, and investigated the underlying mechanisms associated with alteration of Wnt/ß-catenin signaling pathway. Rabbit osteoblasts incubated on titanium alloy implant were co-cultured with normal serum (NS), diabetic serum (DS), DS + OP-D, DS + NAC (a potent ROS inhibitor) and DS + OP-D + Dkk1 (a Wnt inhibitor) for examinations of osteoblast behaviors. For in vivo study, titanium alloy implants were implanted into the femoral condyle defects on diabetic rabbits. Results demonstrated that diabetes-induced oxidative stress resulted in osteoblast dysfunctions and apoptotic injury at the bone-implant interface, concomitant with the inactivation of Wnt/ß-catenin signaling. Importantly, OP-D administration attenuated oxidative stress, directly reactivating Wnt/ß-catenin signaling. Osteoblast dysfunctions were thus reversed as evidenced by improved osteoblast adhesion, proliferation and differentiation, and ameliorated apoptotic injury, exerting similar effects to NAC treatment. In addition, the positive effects afforded by OP-D were confirmed by improved osteointegration and oetogenesis within the titanium alloy implants in vivo by Micro-CT and histological analyses. Furthermore, the pro-osteogenic effects of OP-D were almost completely abolished by the Wnt inhibitor Dkk1. These results demonstrated, for the first time, OP-D administration alleviated the damaged osteointegration of titanium alloy implants under diabetic conditions by means of inhibiting oxidative stress via a Wnt/ß-catenin-dependent mechanism. The OP-D administration would become a reliable treatment strategy for implant failure therapy in diabetics due to the optimal anti-oxidative and pro-osteogenic properties.


Assuntos
Ligas , Antioxidantes/farmacologia , Diabetes Mellitus Experimental/fisiopatologia , Osseointegração/efeitos dos fármacos , Próteses e Implantes , Espécies Reativas de Oxigênio/metabolismo , Saponinas/farmacologia , Espirostanos/farmacologia , Titânio , Via de Sinalização Wnt/efeitos dos fármacos , beta Catenina/metabolismo , Fosfatase Alcalina/metabolismo , Animais , Antioxidantes/metabolismo , Apoptose/efeitos dos fármacos , Regeneração Óssea , Interface Osso-Implante , Adesão Celular , Proliferação de Células/efeitos dos fármacos , Células Cultivadas , Diabetes Mellitus Experimental/metabolismo , Masculino , Osteoblastos/citologia , Osteoblastos/enzimologia , Estresse Oxidativo , Impressão Tridimensional , Coelhos , Regeneração/efeitos dos fármacos
9.
Sci Rep ; 8(1): 6270, 2018 04 19.
Artigo em Inglês | MEDLINE | ID: mdl-29674653

RESUMO

Recent trends have led to an interest in Ponseti treatment for correcting neglected congenital clubfoot. Although good clinical and functional outcomes have been reported, the plantar pressure distribution after the treatment of neglected clubfoot has not been explored yet. The present study aimed to investigate whether plantar pressures normalized following Ponseti treatment in patients with neglected congenital clubfoot. Pedobarographic, clinical, and functional examinations were performed in 22 children (aged, 91.0 ± 40.3 months) with unilateral neglected congenital clubfeet, treated using Ponseti method at 27.8 ± 12.1 months of age. Plantar pressure parameters were recorded using a Footscan pressure plate. The contact time, contact area, peak pressure, and pressure-time integral were determined. The data of the affected feet were compared with those of the unaffected feet and healthy controls. Although clinical and functional examinations showed satisfactory results according to the Dimeglio and Pirani scores, considerable differences in plantar pressure parameters were identified among the affected feet, unaffected feet, and healthy controls. Internal foot progression angle and a load transfer from the medial forefoot and hindfoot to the lateral forefoot and midfoot were observed in the affected feet. Future studies should attempt to investigate the factors accounting for plantar pressure deviations and the possible effect of these deviations on the lower limb musculoskeletal development of children.


Assuntos
Pé Torto Equinovaro/cirurgia , Manipulação Ortopédica/métodos , Criança , Pré-Escolar , Pé Torto Equinovaro/fisiopatologia , Humanos , Pressão , Resultado do Tratamento
10.
Medicine (Baltimore) ; 97(12): e0216, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29561448

RESUMO

BACKGROUND: Amounts of clinic research have been performed to investigate the increment of cross-sectional area in single-door cervical laminoplasty (SDCL). However, no one has taken the effects of surgery drill into consideration. METHODS: A mathematical model was built to investigate the relation of actual laminoplasty opening size (LOS), the transverse canal diameter (TCD), and the increment of cross-sectional area in SDCL). The model was based on geometric analysis on deformation of spinal canal; the relation was derived and characterized as: (Equation is included in full-text article.), where a is the TCD, b the actual LOS, c the size of mini-plate, and d is diameter of the surgery drill bit. In the equation, the related variables would be measured to estimate the increment of cross-sectional area before the surgery. In the current research, 25 patients authorized to use their CT scans of C3∼C7 as the subject samples. RESULTS: The effects of surgery SDCL were very significant; for each patient, the cross-sectional area was enlarged dramatically after the surgery (P < .01). On the contrary, the difference between the cross-sectional area obtained by the equation and that measured by software was statistically negligible (P > .05), which confirmed the reliability of the modeling equation. CONCLUSIONS: Before the SDCL, increment of the cross-sectional area can be estimated by the above-mentioned modeling equation with a high-level reliability. This method ensures the optimum selection of mini-plate before operation for each patient.


Assuntos
Vértebras Cervicais/cirurgia , Laminoplastia/instrumentação , Laminoplastia/métodos , Adulto , Idoso , Vértebras Cervicais/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Teóricos , Tamanho do Órgão , Ossificação do Ligamento Longitudinal Posterior/diagnóstico por imagem , Ossificação do Ligamento Longitudinal Posterior/cirurgia , Doenças da Medula Espinal/diagnóstico por imagem , Doenças da Medula Espinal/cirurgia
11.
Biomed Environ Sci ; 30(12): 938-942, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29335066

RESUMO

Prolactinoma is an estrogen-related tumor and leukemia-related protein 16 (LRP16) is correlated with the progression of estrogen-related tumors, but the regulatory mechanism between LRP16 and prolactinoma remain unclear. This study demonstrates a variation in LRP16 with estrogen receptor α (ERα) in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells (GH3 cells). In our study, 50 male SD rats (30-day-old) were randomly divided into five groups of 10 rats each. After 120 days of treatment, the rats were sacrificed, and the expression of LRP16 and ERα were examined by Western blot and immunohistochemistry to explore the changes in ERα, LRP16, and prolactin. After siRNA transfection of the respective genes, the GH3 cells were cultured, and their secretory function as well as the expression of ERα mRNA and prolactin were analyzed by enzyme-linked immunosorbent assay and real-time-polymerase chain reaction analysis. The results show that secretion of prolactin by GH3 cells can be affected by up and downregulating LRP16 expression, which may provide a novel medical therapy in clinical trials.


Assuntos
Receptor alfa de Estrogênio/metabolismo , Proteínas de Neoplasias/metabolismo , Neoplasias Hipofisárias/metabolismo , Prolactina/metabolismo , Prolactinoma/metabolismo , Fatores de Transcrição/metabolismo , Animais , Linhagem Celular Tumoral , Regulação para Baixo , Masculino , Ratos Sprague-Dawley , Regulação para Cima
12.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 47(1): 6-9, 2012 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-22490211

RESUMO

OBJECTIVE: To analyze the relationship between Class III malocclusion and pathological changes in temporomandibular joint (TMJ) structures using magnetic resenonce imaging (MRI). METHODS: Twenty-four Class III malocclusion adult patients and 10 normal control cases were included in the study. The characteristics of lateral pertygoid muscle (LPM) in the sample group and the control group were assessed. RESULTS: More pathological changes of LPM were found in Class III malocclusion adult patients (36 TMJ). The changes included hypertrophy, atrophy and contracture. And there was no relation between the pathological changes of LPM and the symptom of temporomandibular disorders (TMD). CONCLUSIONS: The frequency of pathological changes of LPM was greater in patients with Class III malocclusion than in the control group.


Assuntos
Imagem por Ressonância Magnética/métodos , Má Oclusão de Angle Classe III/patologia , Músculos Pterigoides/patologia , Adolescente , Adulto , Atrofia/patologia , Estudos de Casos e Controles , Contratura/patologia , Feminino , Humanos , Masculino , Má Oclusão de Angle Classe III/complicações , Articulação Temporomandibular/patologia , Transtornos da Articulação Temporomandibular/complicações , Transtornos da Articulação Temporomandibular/patologia , Adulto Jovem
13.
Br J Sports Med ; 45(4): 270-4, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21047841

RESUMO

OBJECTIVE: How to organise an appropriate team to provide quality dental care during the Olympic Games has become an important consideration for each successive host country. The aims of this study were to document dental services provided at the Olympic Games and to provide data for planning future events. SET-UP OF THE DENTAL CARE DEPARTMENT: There were six dental chairs in six independent treatment rooms, one technical laboratory, a sterilising room and an x-ray room equipped with one digital panoramic screening machine and one intraoral x-ray machine in the polyclinic in the Olympic Village in Beijing. Shifts comprised 80 dentists and 28 nurses who were organised into three shifts working from 08:00 until 23:00. RESULTS: In the 2008 Olympic Games, there were 1607 cases involving 1126 patients requiring dental care: 795 cases from 516 athletes; 483 cases from 370 coaches and other staff; and 99 cases from volunteers. Endodontic treatments, permanent fillings, oral hygiene, mouthguards and treatment of pericoronitis were the most frequent procedures in dental care. The Mouthguard Service was extremely popular and well utilised. 122 athletes received new custom-made mouthguards in Beijing. CONCLUSIONS: As the utilisation of the dental service grows, and the burden of providing care for such a large cohort increases, a well-organised dental team becomes increasingly important. More general-practice dentists were needed in the team. Different kinds of specialist were suggested for working in the team-for example, oral and maxillofacial surgeons, sport dentists for mouthguards and endodontists.


Assuntos
Assistência Odontológica/organização & administração , Esportes/estatística & dados numéricos , China , Assistência Odontológica/estatística & dados numéricos , Restauração Dentária Permanente/estatística & dados numéricos , Humanos , Protetores Bucais/estatística & dados numéricos , Visita a Consultório Médico/estatística & dados numéricos , Higiene Bucal/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Tratamento do Canal Radicular/estatística & dados numéricos , Fatores de Tempo
14.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 45(1): 16-9, 2010 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-20368034

RESUMO

OBJECTIVE: To investigate the relationship between condyle movement and temporomandibular disorders (TMD) in patients with Class II division 1 malocclusion. METHODS: Twenty patients (from 11 to 12 years old) with Class II division 1 malocclusion before treatment were collected. Computer aided diagnosis axiograph (CADIAX) and magnetic resonance images (MRI) were used to analyze the condyle movement between disc displacement and normal groups. RESULTS: The sensitive values were found in open/close process in patients with disc displacement: Y [Left: (0.32 +/- 0.10) mm, Right: (-0.91 +/- 0.49) mm ], Z [Left: (4.20 +/- 0.70) mm, Right: (3.44 +/- 0.21) mm], sagittal condylar inclination (SCI) [Left: (32.48 +/- 7.70) degrees , Right: (33.47 +/- 12.60) degrees ] and horizontal condylar inclination (TCI) [Left: (-2.60 +/- 2.02) degrees , R: (-9.23 +/- 5.58) degrees ], and those items showed significant difference between two groups. CONCLUSIONS: The side shift of condyle movement in maximum open/close process might be the inducement of disc displacement. It was revealed that the changes in condyle movement could give useful information in early stage of functional treatment.


Assuntos
Má Oclusão de Angle Classe II/fisiopatologia , Côndilo Mandibular/patologia , Movimento , Disco da Articulação Temporomandibular/patologia , Transtornos da Articulação Temporomandibular/patologia , Criança , Diagnóstico por Computador/instrumentação , Feminino , Humanos , Registro da Relação Maxilomandibular , Masculino , Má Oclusão de Angle Classe II/complicações , Côndilo Mandibular/fisiopatologia , Transtornos da Articulação Temporomandibular/etiologia
15.
Zhong Yao Cai ; 31(6): 853-5, 2008 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-18998568

RESUMO

OBJECTIVE: To study the chemical constituents from the ethanolic extract of Alpinia katsumadai Hayata. METHODS: The compounds were separated with the column chromatographic, and their structures were identified by chemical and spectroscopic methods. RESULTS: Eight compounds were isolated from the ethanol extract. On the basis of their physical and chemical properties and spectroscopic analysis, the structures of seven compounds were identified. They were 1,7-Diphenyl-5-hydroxy-4, 6-heptadien-3-one(I), 1,7-Diphenyl4, 6-heptadien-3-one(II), Pinocembrin (III), Cardamomin (IV), Alpinetin (V), 7,4'-Dihydroxy-5-methoxy flavanones(VI) and beta-Sitosterol(VIII), respectively. CONCLUSION: Compounds I , II and VII are separated from this plant for the first time. Compounds I and II are also obtained from this genus of Alpinetin for the first time.


Assuntos
Flavanonas/isolamento & purificação , Plantas Medicinais/química , Sitosteroides/isolamento & purificação , Zingiberaceae/química , Chalconas/química , Chalconas/isolamento & purificação , Flavanonas/química , Sementes/química , Sitosteroides/química , Espectrofotometria Ultravioleta
16.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 43(7): 437-8, 2008 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-19031825

RESUMO

OBJECTIVE: To analyze the relationships between MRI image changes of lateral pterygoid muscle (LPM), disc position and condylar mobility. METHODS: Twenty Class II patients were chosen and MRI images of LPM were taken. The relationships between MRI image changes of LPM, disc position and condylar mobility were analyzed. RESULTS: The rate of MRI image changes of LPM in Class II patients was about 45%. No significant correlations were found between MRI image changes of LPM, condylar mobility and disc position. CONCLUSIONS: MRI image changes of LPM in Class II patients was common but no significant correlations were found between MRI image changes of LPM, condylar mobility and disc position.


Assuntos
Má Oclusão de Angle Classe II/patologia , Má Oclusão de Angle Classe II/fisiopatologia , Músculos Pterigoides/patologia , Articulação Temporomandibular/fisiopatologia , Criança , Feminino , Humanos , Imagem por Ressonância Magnética , Masculino , Amplitude de Movimento Articular
17.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 42(8): 475-6, 2007 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-18001590

RESUMO

OBJECTIVE: To record and analyze the characteristics of condyle movement before and after functional treatment in Angle class II division 1 malocclusion (II(1)) patients. METHODS: Twenty Angle II(1) patients were included in the study and 20 Angle I patients without temporomandibular disorders symptoms served as controls. Computer aided diagnosis axiograph (CADIAX) was used to record the condyle movement in Angle II(1) patients and that caused by functional appliance treatment during mouth opening and closing. RESULTS: The tracing were vertically displayed. Value Z [L: 2.21 (1.01) mm, R: 1.12 (1.02) mm] and sagittal condylar inclination [L: 12.89 (9.12) degrees, R: 12.12 (8.89) degrees] were increased significantly in Angle II(1) patients compared with those in control group (P < 0.05). After functional treatment, the condyle movement in Angle II(1) patients was close to normal (P > 0.05). CONCLUSIONS: Typical characteristics of condyle movement were found in Angle II(1) patients and it was stable and repeatable. Functional therapy had a positive effect on temporomandibular joint function in Angle II(1) patients.


Assuntos
Má Oclusão de Angle Classe II/fisiopatologia , Articulação Temporomandibular/fisiopatologia , Feminino , Humanos , Masculino , Má Oclusão de Angle Classe II/terapia , Côndilo Mandibular/fisiopatologia
18.
Basic Clin Pharmacol Toxicol ; 99(6): 425-30, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17169123

RESUMO

The aim of this study is to investigate the hypotensive and vasodilator effects of daidzein sulfates, a water-solubility derivative of daidzein. Tail cuff blood pressure of spontaneously hypertensive rat (SHR) was measured with non-invasive Electro-Sphygmomanometer. An isometric tension of rat mesenteric artery ring segments was recoded in vitro on a myograph. The results showed that daidzein sulfates (20 and 40 mg/kg) could decrease blood pressure of SHR in single dose and multi-doses. Daidzein sulfates (1-100 microM) inhibited the contraction of rat mesenteric arterial ring segments induced by norepinephrine (NA) and 5-hydroxytryptamine (5-HT). Daidzein sulfates (100-1000 microM) inhibited arterial segment's contraction induced by KCl and CaCl(2). The concentration- contractive curves were shifted toward right in a non-parallel manner with decreased E(max.) Daidzein sulfaltes inhibited the extracellular Ca(2+)-dependent contraction. Daidzein sulfates of 100 and 300 microM significantly inhibited the contraction induced by CaCl(2) in Ca(2+)-free solution, which is an extracellular Ca(2+)-dependent contraction; but daidzein sulfates did not inhibit the intracellular Ca(2+)-dependent NA-induced contraction, in Ca(2+)-free solution. The results suggest that daidzein sulfates possess significant hypotensive and vasodilator effects which mainly derive from artery smooth muscle cells by inhibiting the receptor-mediated Ca(2+)-influx.


Assuntos
Hipertensão/tratamento farmacológico , Isoflavonas/farmacologia , Fitoestrógenos/farmacologia , Ésteres do Ácido Sulfúrico/farmacologia , Vasodilatadores/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Cálcio/metabolismo , Cloreto de Cálcio/farmacologia , Hipertensão/fisiopatologia , Técnicas In Vitro , Masculino , Artérias Mesentéricas/efeitos dos fármacos , Artérias Mesentéricas/fisiologia , Artérias Mesentéricas/fisiopatologia , Norepinefrina/farmacologia , Cloreto de Potássio/farmacologia , Ratos , Ratos Endogâmicos SHR , Ratos Sprague-Dawley , Serotonina/farmacologia
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