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1.
J Nutr ; 2020 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-32140711

RESUMO

BACKGROUND: Due to a lack of research data on the protein requirements of the elderly in China, the estimated average requirement (EAR) and the recommended nutrient intake (RNI) of protein in the elderly remain the same as those in young and middle-aged people at 0.98 g/(kg·d). OBJECTIVE: The objective of this study was to determine the protein requirements of healthy Chinese adults >65y old through use of the indicator amino acid oxidation (IAAO) method. METHODS: Seven healthy adult men and 7 healthy adult women participated in the study, with protein intakes ranging from 0.3 to 1.8 g/(kg·d). The diets were isocaloric and provided energy at a 1.5 resting energy expenditure. Protein was given based on the lactalbumin. Phenylalanine and tyrosine were added to protein doses of 0.3-1.5 g/kg according to the highest dose of protein content [1.8 g/(kg·d)]. Phenylalanine and tyrosine concentrations were kept constant at each protein dose. The mean protein requirement was determined by applying a nonlinear mixed-effects model analysis to the F13CO2, which identified a breakpoint in F13CO2 in response to graded amounts of protein. This trial was registered with the Chinese clinical trial registry as ChiCTR-BOC-17010930. RESULTS: Protein EAR and RNI for healthy elderly Chinese adults were determined to be 0.91 and 1.17 g/(kg·d), respectively, based on the indicator amino acid oxidation technique. CONCLUSIONS: The estimates of protein requirements for Chinese adults >65 y in the present study are 3.4% and 19.4% higher than the current estimated requirements, 0.88 g/(kg·d) for EAR and 0.98 g/(kg·d) for RNI.

2.
Org Lett ; 2020 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-32105085

RESUMO

Herein we report the design and synthesis of hypervalent trifluoromethylthio-iodine(III) reagent 1 and the elucidation of its structure by NMR spectroscopy and X-ray crystallography. The trifluoromethylthiolation reactions of 1 with various nucleophiles were explored, and this compound was found to be a versatile electrophilic reagent for the transfer of a trifluoromethylthio group (-SCF3). The hydrogen-bonding mode responsible for the activation of 1 by the solvent 1,1,1,3,3,3-hexafluoro-2-propanol was investigated both experimentally and computationally.

3.
Int J Biometeorol ; 2020 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-32040625

RESUMO

The stability of maize production is essential to global food security. Climate factors, such as temperature, precipitation, and solar radiation, directly affect the development of maize plants and hence the final grain yield. In this study, we investigated the spatial distributions and temporal trends of agro-climatic indices and severe weather indicators during the actual growing season for summer maize in Huanghuaihai region of China. The results showed that during the growing season, accumulated effective thermal time had significantly increased. From R3 to R6, accumulated effective thermal time, effective precipitation, and photosynthesis active radiation all showed an increasing trend, with the rate of 20.3 °C day, 1.1 mm, and 7.3 MJ m-2 per decade, respectively. From VE to R3, most of the study years showed a > 50% ratio of high-temperature days to subtotal days and > 7 consecutive days without available precipitation. During most of the study years, there were at least 0.5 thunderstorm events from V6 to VT stage in the locations of study; days with strong winds accounted for more than half the subtotal days during the V6-VT stage. And potential risk of lodging may be reduced by the decrease in days with strong wind. The results of this study could be used in optimizing agricultural management in summer maize production in order to take advantage of beneficial climatic elements while combating adverse climatic elements.

4.
Thyroid ; 30(3): 443-450, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31964276

RESUMO

Background: Remarkable achievements have been made for over two decades by implementing a universal salt iodization policy in China. However, changes in the standards and manufacturing of iodized salt have made it necessary to regularly monitor iodine intake and thyroid function in the population. Therefore, we aimed to evaluate iodine nutritional status using thyroid function and urinary iodine levels in pregnant women via a national survey. Methods: Participants included pregnant women enrolled in the 2015 Chinese Adults Chronic Diseases and Nutrition Surveillance (CACDNS). Urinary iodine concentration (UIC) was measured using arsenic and cerium catalysis spectrophotometry. Plasma levels of thyrotropin (TSH), fT4 (free thyroxine), thyroid peroxidase antibodies (TPO-Ab), and thyroglobulin antibodies (TG-Ab) were determined using an automated chemiluminescence immunoassay analyzer. Results: UIC was analyzed in a total of 6173 urinary samples collected from pregnant women residing in 31 provinces of China. The median urinary iodine concentration was 146 µg/L. Pregnant women with UIC >250 µg/L had higher TSH levels than those with UIC 120-149 and 150-249 µg/L. After excluding women with positive TPO-Ab and TG-Ab, a total 2097 plasma samples collected from pregnant women during three periods were analyzed for TSH and fT4. The frequency of normal thyroid function in this study was >85%. The most common type of abnormal thyroid function, subclinical hypothyroidism, was similar to the 2010-2012 China Nutrition and Health Surveillance (CNHS), but its prevalence decreased to 6.8% compared with that in the 2010-2012 CNHS. Compared with pregnant women who had UIC <250 µg/L, the prevalence of subclinical hypothyroidism was significantly increased in those with UIC >250 µg/L. Even with UIC levels 120-149 µg/L, the iodine status of Chinese pregnant women in the 2015 CACDNS is acceptable. Conclusions: The iodine status of pregnant women is generally adequate, but urinary iodine levels are close to the cutoff for suitable iodine status (150 µg/L). With noniodized salt widely available, continued improvement in monitoring of iodine nutritional status and thyroid function is important in this population.

5.
Int J Biometeorol ; 64(1): 165, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31889211

RESUMO

Due to an author oversight, the original article was published with erroneous funding information in the acknowledgement section.

6.
Org Lett ; 21(22): 8948-8951, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31674790

RESUMO

An efficient and practical approach for the synthesis of substituted benzannulated seven-membered O-heterocycles from cyclopropane derivatives is described. The transformation proceeds via Lewis acid mediated ring opening of cyclopropanes followed by a concomitant 7-endo-tet cyclization to furnish the 4-benzoyl-3,4-dihydrobenzo[b]oxepin-5(2H)-one derivatives in excellent yields (up to 92%). This potentially general method is featured by its high atom economy, broad substrate scope, and mild reaction conditions. Moreover, the representative products exhibited selective antifungal activity in vitro against the fungus Cryptococcus neoformans. Therefore, the present reaction will be useful for the development of novel antifungal therapeutic reagents.

7.
Nutr Metab (Lond) ; 16: 62, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31516542

RESUMO

Background: The WHO/UNICEF/ICCIDD define iodine deficiency during pregnancy as median urinary iodine concentration (MUIC) ≤ 150 µg/L. China implemented universal salt iodization (USI) in 1995, and recent surveillance showed nationwide elimination of iodine deficiency disorders (IDD). Data from 2014 showed that the MUIC in 19,500 pregnant women was 154.6 µg/L and 145 µg/L in 9000 pregnant women in 2015. However, symptoms of iodine deficiency were absent. Our study sought to evaluate whether MUIC below 150 µg/L affects thyroid function of Chinese pregnant women and their newborns in Chinese context. Methods: We screened 103 women with normal thyroid function and MUIC lower than 150 µg/L during week 6 of pregnancy at Peking Union Medical College Hospital. Patient demographics and dietary salt intake were recorded. Subjects were followed at 12, 24, and 32 gestational weeks. At each visit, a 3-day dietary record, drinking water samples, and edible salt samples were collected and analyzed for total dietary iodine intake. Additionally, 24-h urine iodine and creatinine were measured. Blood tests assessed thyroid function in both mothers and newborns. Results: Of 103 pregnant women enrolled, 79 completed all follow-up visits. Most subjects maintained normal thyroid function throughout pregnancy. However, 19 had thyroid dysfunction based on thyroid stimulating hormone and free thyroxine levels. The median serum iodine was 71 µg/L (95% CI: 44, 109). The median thyroglobulin was < 13 µg/L. values above this level indicate iodine deficiency in pregnant women. The median dietary iodine intake during pregnancy, derived from the 3-day record and measures of water and salt, was 231.17 µg/d. Assuming 90% urinary iodine excretion (UIE), 200.11 µg/d UIE means the 222.34 µg iodine loss per day, suggesting that subjects had a positive iodine balance throughout pregnancy. All neonatal blood samples showed TSH levels lower than 10 mIU/L, indicating normal thyroid function. No significant difference was found among gestational weeks for urinary iodine, and the MUIC in subjects who completed 3 follow-up visits was 107.41 µg/L. Conclusion: Twenty years after implementing USI, expectant Chinese mothers with MUIC of 107.4 µg/L, less than the WHO's 150 µg/L benchmark, maintained thyroid function in both themselves and their newborn babies.

8.
Front Oncol ; 9: 887, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31552191

RESUMO

Tumor plasticity refers to tumor cell's inherent property of transforming one type of cell to different types of cells. Tumor plasticity is the main cause of tumor relapse, metastasis and drug resistance. Cancer stem cell (CSC) model embodies the trait of tumor plasticity. During carcinoma progression, epithelial-mesenchymal transition (EMT) plays crucial role in the formation of CSCs and vasculogenic mimicry (VM) based on epithelial-mesenchymal plasticity. And the unique tumor microenvironment (TME) not only provides suitable niche for CSCs but promotes the building of CSCs and VM that nourishes tumor tissue together with neoplasm metabolism by affecting tumor plasticity. Therapeutic strategies targeting tumor plasticity are promising ways to treat malignant tumor. In this article, we discuss the recent developments of potential drug targets related to CSCs, EMT, TME, VM, and metabolic pathways and summarize drugs that target these areas in clinical trials.

9.
Eur J Pharmacol ; 863: 172680, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31563649

RESUMO

Psoriasis is a common dermatosis causing considerable inconvenience to 4% of the general population. Traditional psoriasis treatments often cause side effects, drug resistance and complications, necessitating development of safer and more effective treatments. In this study, we screened over 600 natural compounds to identify viability inhibitors of human HaCaT keratinocytes cultured in vitro. The results showed that nitidine chloride was a highly effective inhibitor. Further studies revealed that nitidine chloride inhibited HaCaT proliferation and induced S phase cell cycle arrest; these effects were associated with reduced DNA synthesis, decreased Ki67, cyclin A, and cyclin D1 levels, and increased p53 protein expression. Nitidine chloride also significantly downregulated bcl-2 and upregulated bax, cleaved caspase-9 and cleaved caspase-3. Mechanistic studies revealed that nitidine chloride-induced apoptosis involved the c-Jun N-terminal kinase (JNK) pathway. More importantly, in 12-O-tetradecanoyl-phorbol-13-acetate (TPA)- and imiquimod (IMQ)-induced epidermal hyperplasia and inflammation models, nitidine chloride inhibited topical edema in mouse ear and back skin, substantially reducing tissue thickness and weight. In some cases, nitidine chloride also ameliorated conditions caused by TPA and IMQ, such as angiogenesis and infiltration of large numbers of inflammatory cells around blood vessels. Additionally, nitidine chloride inhibited the expression of various proinflammatory cytokines in the two animal models. In conclusion, our results are the first to demonstrate that nitidine chloride inhibits the proliferation of HaCaT cells, induces apoptosis partly via the JNK signaling pathway in vitro and ameliorates skin lesions and inflammation in vivo, making it an appropriate candidate for psoriasis treatment.

10.
Asia Pac J Clin Nutr ; 28(3): 621-633, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31464410

RESUMO

BACKGROUND AND OBJECTIVES: The purpose of our study was to estimate the national prevalence of metabolic syndrome, its individual components and its changes in the past decade. METHODS AND STUDY DESIGN: Two national-representative cross-sectional surveys: the China National Nutrition and Health Survey 2002 (CNNHS 2002) and the Chinese National Nutrition and Health Surveillance 2010-2012 (CNNHS 2010-2012). A total of 48,235 and 104,098 participants aged 18 years or older who had completed data on physical examination, blood lipids, and fasting glucose tests from CNNHS 2002 and CNNHS 2010-2012, respectively, were included in current study. RESULTS: The prevalence of metabolic syndrome in Chinese adults increased from 9.5% (95% confident interval [CI]: 9.2%-9.7%) in 2002 to 18.7% (18.3%-19.1%) in 2010-2012, corresponding to an estimated 83.6 million adults in 2002 and 189 million adults in 2010-2012 living with metabolic syndrome in China. The increment was more than doubled among young, rural residents and those from poor households. Abdominal obesity, hyperglycemia, high triglycerides, low HDL-C, and elevated blood pressure were found in 18.9% (18.5%-19.3%), 6.4% (6.2%-6.7%), 13.8% (13.5%-14.2%), 19.3% (18.9%-19.7%), and 34.0% (33.5%-34.5%) of adults in 2002, respectively, which was 25.8% (25.3%-26.2%), 16.2% (15.8%-16.5%), 23.7% (23.3%-24.2%), 32.6% (32.0%-33.1%), and 34.4% (33.9%-34.9%), respectively, in 2010-2012. CONCLUSIONS: Based on two nationally representative surveys, our results indicated that the prevalence of metabolic syndrome is widespread and increasing in China.


Assuntos
Inquéritos Epidemiológicos , Síndrome Metabólica/epidemiologia , Adulto , Idoso , China/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
11.
Nutr Metab (Lond) ; 16: 55, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31452667

RESUMO

Background: Iron nutrition is important for the health of women of reproductive age, and defining the physiologic requirement for iron can help them accurately plan the iron intake. However, research on the physiologic requirement for iron in women is insufficient worldwide. This study aimed to further improve the methodology and get more precise data for the physiological requirements for iron in women of reproductive age on the basis of our previous study. Method: Sixty-one women of reproductive age who had not been pregnant before and during the whole study were included from Hebei province, China in 2015. Each subject participated in a 2-week metabolic trial with consuming 50 mg of the stable isotope 58Fe, and were then followed for ~ 800 days. The abundance of 58Fe and the total iron concentration in the circulation were measured using multi-collector inductively-coupled plasma mass spectrometry and atomic absorption spectroscopy. The physiologic requirement for iron in women of reproductive age was then calculated. Results: The average iron circulation rate was 80.4%, and the steady period started from about 1 year. The average physiological requirement for iron of 21 subjects obtained by formula calculation was 1.55 mg/d and 23.63 µg.kg- 1.d- 1 after adjustment for body mass, and that of 33 subjects obtained by linear regression was 1.29 mg/d, 20.98 µg.kg- 1.d- 1 after adjustment for body mass. The results by two methods showed no significant difference. The EAR and RNI calculated from this results was 11-13 mg/d and 15-18 mg/d, respectively, both of which were slightly lower than the recommended value in Chinese Dietary Reference Intake (2013). Conclusion: The physiological requirements for iron in women of reproductive age were in accordance with other studies, while the EAR and RNI calculated from which were slightly lower than Chinese present recommended value. Trial registration: ChiCTR, ChiCTR-OCH-14004302. Registered 14 February 2014, http://www.chictr.org.cn/enindex.aspx.

12.
Int J Biometeorol ; 63(12): 1659-1668, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31446481

RESUMO

Reasonable crop planting division is important for farmers to grow suitable plants and for decision makers to make short- and long-term plans. In this study, we assessed the cropping suitability for maize in the three main growing regions in China, including the North China Spring Maize Region (NCS), the Huanghuaihai Summer Maize Region (HS), and the Southwest China Mountain Maize Region (SCM). We determined the spatial patterns of cropping suitability for maize and the dominant climate and soil drivers by assessing both yield level and yield stability (high-stable index (HSI)) under four production input levels (simulated yield potential (Yp), water-limited yield (Ypw), and water-limited-soil-constrained yield (Ypws) by APSIM-Maize model and actual yield (Ya)) during the period of 1981-2010. According to the HSI of Yp for maize, optimal and suitable areas for maize production were focused in NCS and HS. In SCM, the percentages of subtotal optimal and suitable areas for both simulated Ypw and Ypws to total regional area were higher than those in NCS and HS. Yield level of Ya was significantly higher in NCS and HS than in SCM, while yield stability of Ya in NCS was significantly lower than that in the other two study regions. Based on Ya, HS (SCM) showed the largest (smallest) optimal and suitable areas for maize production. In addition, the percentage of subtotal optimal and suitable area to total regional area is the highest in HS. Under the Yp level, solar radiation was the dominant factor for cropping suitability in the three study regions. Under the Ypw and Ypws levels, precipitation was the driving factor for cropping suitability in NCS and HS, while solar radiation and soil water properties were the driving factors for cropping suitability in SCM. These results can be used to assist local policy makers in dividing maize-growing regions in China. Hence, local farmers could choose the most suitable varieties accordingly in order to maximize the yield production while maintaining a relatively high yield stability.


Assuntos
Agricultura , Zea mays , China , Clima , Solo
13.
Dalton Trans ; 48(34): 12850-12857, 2019 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-31393486

RESUMO

Even though various theranostic agents have been exploited for effective cancer therapy over the years, appropriate design and fabrication of theranostic agents with simple composition, convenient preparation, high theranostic efficiency and minimal side effects on non-cancer cells are still urgently needed. Herein, multifunctional NaYF4:Yb,Er@polyelectrolyte (PE3)@Fe3O4 nanocomposites, with upconversion luminescence, superparamagnetism and photothermal performance, are prepared by a layer-by-layer self-assembly technique. Compared with Fe3O4 nanoparticles (NPs), the nanocomposites exhibited nearly 2-fold strong absorption at 808 nm, and thus resulted in an enhanced near-infrared photothermal effect. With the assistance of an external magnetic field, a high sensitivity of upconversion fluorescence imaging and a low cancer cell viability of 13.9% were achieved under 808 nm laser irradiation. It is expected that multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites would pave the way toward promoting the clinical applications of theranostic nanomaterials.


Assuntos
Érbio/química , Campos Magnéticos , Nanocompostos , Imagem Óptica/métodos , Fototerapia/métodos , Itérbio/química , Ítrio/química , Animais , Linhagem Celular Tumoral , Luminescência , Camundongos
14.
Materials (Basel) ; 12(16)2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31443322

RESUMO

Fabricating an Inconel 718 superalloy using electromagnetic stirring assisted laser solid forming (EMS-LSF) is a novel method to modify its microstructure and mechanical properties by consuming the Nb element in the γ phase to alleviate interdendritic segregation. The precipitate of the δ phase at 950 °C after EMS-LSF can help to achieve the uniform diffusion of Nb, and can also improve its mechanical properties. The precipitation behavior of the δ phase in an EMS-LSF Inconel 718 superalloy with different heat treatment processes has been investigated. The results show that the morphology of the δ phase changes from rod-like to a long-needle shape and tends to grow from the inter dendrite to the core dendrite with electromagnetic field intensity increasing, which is accompanied by the "cutting" and "dissolution" of the Laves phase. Through precipitation kinetics analysis, the precipitation rate of the δ phase is seen to increase with the electromagnetic field intensity increasing. Under a combination of electromagnetic stirring and laser solid forming, the microhardness of the Inconel 718 samples increased slightly due to the fact that a higher content of Nb was distributed in the core dendrite resulting from the serious convection of liquid metal, which can strengthen the matrix.

15.
ACS Appl Mater Interfaces ; 11(29): 26491-26499, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31294548

RESUMO

High-work function (WF) transparent conductive thin films improve the performance of solar cells and organic light-emitting diodes by facilitating interfacial charge carrier transport. Al-doped ZnO (AZO) becomes a very promising transparent conductive material because of nontoxicity, abundant material resources, and low cost. To increase the WF of AZO without enhancing the series resistance of the device, a high-WF and low-resistance surface modifier of polycrystalline zinc molybdenum oxide (ZMO) was developed by utilizing thermal evaporation of MoO3 on the surface of AZO and a subsequent two-step annealing treatment. The first step of air annealing causes the formation of monoclinic ZnMoO4 nanocrystals in the ZMO modifier. This improves the WF of AZO from 3.83 to 4.86 eV by increasing the group electronegativity and cation oxidation state. Furthermore, the second step of N2 annealing decreases the resistivity of the polycrystalline ZMO by increasing the donor states of oxygen vacancies. The surface modification effect is verified by applying the ZMO-modified AZO to the front electrode of hydrogenated amorphous silicon thin-film solar cells. The low-resistance polycrystalline ZMO modifier not only increases light harvesting in the solar cells by improving interfacial refractive index matching but also improves the open-circuit voltage by modifying the interfacial band alignment. In particular, the modifier increases the fill factor by ca. 13% by reducing the series resistance of the device. These enable a gain of ca. 23% in photoelectric conversion efficiency compared to the unmodified AZO. The results suggest the feasibility to tune the WF and conductivity of a material independently.

16.
Proc Biol Sci ; 286(1906): 20190791, 2019 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-31288707

RESUMO

With millions of extant species, ecdysozoans (Scalidophora, Nematoida and Panarthropoda) constitute a major portion of present-day biodiversity. All ecdysozoans secrete an exoskeletal cuticle which must be moulted periodically and replaced by a larger one. Although moulting (ecdysis) has been recognized in early Palaeozoic panarthropods such as trilobites and basal groups such as anomalocaridids and lobopodians, the fossil record lacks clear evidence of ecdysis in early scalidophorans, largely because of difficulties in recognizing true exuviae. Here, we describe two types of exuviae in microscopic scalidophoran worms from the lowermost Cambrian Kuanchuanpu Formation ( ca 535 Ma) of China and reconstruct their moulting process. These basal scalidophorans moulted in a manner similar to that of extant priapulid worms, extricating themselves smoothly from their old tubular cuticle or turning their exuviae inside out like the finger of a glove. This is the oldest record of moulting in ecdysozoans. We also discuss the origin of ecdysis in the light of recent molecular analyses and the significance of moulting in the early evolution of animals.

17.
Int J Biol Sci ; 15(7): 1472-1487, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31337977

RESUMO

A decrease in islet ß-cell mass is closely associated with the development and progression of diabetes. Therefore, protection against ß-cell loss is an essential measure to prevent and treat diabetes. In this study, we investigated the protective effects of non-photoactivated hypericin, a natural compound, on ß-cells both in vitro and in vivo. In vitro, hypericin greatly improved INS-1 cell viability under high-glucose and high-fatty-acid conditions by inhibiting glucotoxicity- and lipotoxicity-induced apoptosis and nitric oxide (NO) production. Then, we further demonstrated that hypericin elicited its protective effects against glucotoxicity and lipotoxicity in INS-1 cells by attenuating the reduction in pancreatic duodenal homeobox-1 (PDX1) expression and Erk activity. In vivo, prophylactic or therapeutic use of hypericin inhibited islet ß-cell apoptosis and enhanced the anti-oxidative ability of pancreatic tissue in high-fat/high-sucrose (HFHS)-fed mice, thus alleviating ß-cell loss and maintaining or improving ß-cell mass and islet size. More importantly, hypericin treatment decreased fasting blood glucose, improved glucose intolerance and insulin intolerance, and alleviated hyperinsulinaemia in HFHS-fed mice. Therefore, hypericin showed preventive and therapeutic effects against HFHS-induced onset of type II diabetes in mice. Hypericin possesses great potential for development as an anti-diabetes drug in the future.

18.
Asia Pac J Clin Nutr ; 28(2): 214-222, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31192549

RESUMO

BACKGROUND AND OBJECTIVES: This study assessed the bioavailability and biological incorporation of nonheme iron from staple food diets in healthy young urban Chinese women and determined the relevant effects of typical regional patterns of staple foods in South and North China. METHODS AND STUDY DESIGN: Twenty-two young urban Chinese women aged 20-23 years were enrolled and randomly allocated to two groups, with rice (rice group) and steamed buns (steamed buns group) as the staple food, respectively. Each participant received three meals daily containing approximately 3.25 mg of stable 57FeSO4 for 2 consecutive days, along with daily intravenous injection of approximately 2.0 mg of 58FeSO4. Nonheme iron absorption and infused iron incorporation rates were assayed. RESULTS: In all participants, the rice group, and the buns group, nonheme iron intake was 7.2±1.6, 5.9±0.6, and 8.4±1.2 mg, respectively; mean 57FeSO4 absorption rate was 22.2%±9.6%, 22.2%±10.6%, and 22.2%±8.9%, respectively; and the mean infused 58FeSO4 incorporation rate was 91.6%±8.2%, 93%±7.3%, and 90%±9.1%, respectively. No substantial differences existed in the nonheme iron intakes and the 57FeSO4 absorption and 58FeSO4 incorporation rates between the rice and buns groups (all p>0.05). CONCLUSIONS: The bioavailability and incorporation rates of nonheme iron from representative comprehensive Chinese diets in healthy young urban Chinese women were evaluated. Our results can facilitate the establishment of dietary reference intake for iron in Chinese women.


Assuntos
Dieta/métodos , Ferro na Dieta/metabolismo , Adulto , Disponibilidade Biológica , China , Feminino , Humanos , Ferroproteínas não Heme/metabolismo , População Urbana/estatística & dados numéricos , Adulto Jovem
19.
Molecules ; 24(9)2019 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-31035404

RESUMO

Cancer patients frequently suffer from cancer-related fatigue (CRF), which is a complex syndrome associated with weakness and depressed mood. Neuroinflammation is one of the major inducers of CRF. The aim of this study is to find a potential agent not only on the treatment of cancer, but also for reducing CRF level of cancer patients. In this study, total-thirty new Dihydroartemisinin-Coumarin hybrids (DCH) were designed and synthesized. The in vitro cytotoxicity against cancer cell lines (HT-29, MDA-MB-231, HCT-116, and A549) was evaluated. Simultaneously, we also tested the anti-neuroinflammatory activity of DCH. DCH could inhibit the activated microglia N9 release of NO, TNF-α, and IL-6. The docking analysis was shown that MD-2, the coreceptor of TLR4, might be one of the targets of DCH.


Assuntos
Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Artemisininas/química , Artemisininas/farmacologia , Cumarínicos/química , Cumarínicos/farmacologia , Anti-Inflamatórios/síntese química , Artemisininas/síntese química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Cumarínicos/síntese química , Humanos , Concentração Inibidora 50 , Simulação de Acoplamento Molecular , Simulação de Dinâmica Molecular , Estrutura Molecular , Relação Estrutura-Atividade
20.
Lancet Diabetes Endocrinol ; 7(7): 540-548, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31085143

RESUMO

BACKGROUND: Few studies have used nationally representative data to describe dietary trends and the related cardiometabolic mortality burden in China. Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associated disease burden among Chinese adults from 1982 to 2012. METHODS: For this cross-sectional population-based study, we analysed a nationally representative sample of 204 802 adults aged 20 years or older, using data from the 1982, 1992, 2002, and 2010-12 China National Nutrition Surveys (CNNS). We did a comparative risk assessment, in which the effects of suboptimal intakes of 12 dietary factors, individually and collectively, on cardiometabolic mortality were estimated by calculating the population attributable fraction (PAF) to estimate the proportional reduction in cardiometabolic deaths that would occur if exposure to each dietary risk factor was reduced to an alternative optimal level. FINDINGS: The overall PAF of mortality from cardiovascular disease and type 2 diabetes that was associated with suboptimal dietary quality was 62·2% in 1982, 57·9% in 1992, 56·2% in 2002, and 51·0% in 2010-12, which accounted for 21·6% of total mortality in China in 1982, 16·6% in 1992, 17·6% in 2002, and 20·8% in 2010-12. The estimated number of cardiometabolic deaths associated with suboptimal dietary intakes was 1·07 million in 1982, 0·93 million in 1992, 1·18 million in 2002, and 1·51 million in 2010-12. Of all 12 dietary factors examined, high sodium intake (17·3%), low fruit consumption (11·5%), and low marine omega-3 fatty acids (9·7%) were associated with the largest numbers of estimated cardiometabolic deaths in 2010-12. INTERPRETATION: We observed an improvement in several dietary factors in China in the past few decades. However, current intakes of these dietary factors remain suboptimal. Poor diet quality is estimated to be associated with a substantial proportion of deaths from heart disease, stroke, and type 2 diabetes in China. FUNDING: Ministry of Health, China, and Ministry of Science and Technology, China.

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