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1.
Sci Total Environ ; 715: 136975, 2020 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-32018106

RESUMO

Dissemination of antibiotic resistance genes (ARGs) in the water environment has become an increasing concern. There have been many reports on ARGs in surface water, but little is known about ARGs in groundwater. In this study, we investigated the profiles and abundance of ARGs in groundwater in comparison with those in surface water of Maozhou River using high-throughput quantitative PCR (HT-qPCR). Totally 127 ARGs and 10 MGEs were detected by HT-qPCR, and among them the sulfonamides, multidrug and aminoglycosides resistance genes were the dominant ARG types. According to the results of HT-qPCR, 18 frequently detected ARGs conferring resistance to 6 classes of antibiotics and 3 MGEs were further quantified by qPCR in the wet season and dry season. The absolute abundance ranged from 1.23 × 105 to 8.89 × 106 copies/mL in wet season and from 8.50 × 102 to 2.65 × 106 copies/mL in the dry season, with sul1 and sul2 being the most abundant ARGs. The absolute abundance of ARGs and MGEs has no significant difference between the wet season and dry season while the diversity of ARGs in the dry season was higher than that in the wet season (p < 0.05). Totally 141 and 150 ARGs were detected in the water and sediments of Maozhou River, respectively. A total of 116 ARGs were shared among the groundwater, river water, and sediment, which accounted for 67.1% of all detected genes. Redundancy analysis further demonstrated that the environmental factors contributed 70.7% of the total ARG variations. The findings of large shared ARGs, abundant Total Coliforms and large wastewater burden in the groundwater provide a clear evidence that anthropogenic activities had a significant impact on groundwater.

2.
Surg Today ; 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31925579

RESUMO

PURPOSE: To investigate the efficacy and safety of flurbiprofen axetil in postoperative analgesia in upper abdominal surgery. METHODS: This was a multicenter, randomized, positive drug parallel controlled double-blind clinical study. Patients undergoing upper abdominal surgery were randomly divided to receive flurbiprofen axetil or tramadol. The VAS pain scores at rest and on coughing (pulmonary function training) were assessed immediately before drug usage (T1) to evaluate the efficacy of postoperative analgesia. Repeat assessment of the VAS was performed after T1. The timing of the recovery of the gastrointestinal function and the preoperative and postoperative IL-6, cortisol, and blood glucose levels were recorded as secondary endpoints. Vital signs and the occurrence of adverse reactions were evaluated for the assessment of safety. RESULTS: A total of 240 patients were enrolled in the current study; 119 used flurbiprofen axetil for postoperative analgesia. The VAS scores at rest and on coughing did not differ between the two groups to a statistically significant extent (P > 0.05). However, the reduction of the VAS score at rest in the flurbiprofen axetil group was greater than that in the tramadol group at 4-24 h after T1. The reduction of the VAS score on coughing at 8 h after T1 was greater in the flurbiprofen axetil group. The incidence of adverse reactions was significantly lower in the flurbiprofen axetil group, with only one adverse reaction recorded. In contrast, 18 adverse reactions were reported in the tramadol group. CONCLUSION: Flurbiprofen axetil showed superior efficacy to tramadol in early postoperative analgesia after upper abdominal surgery. Flurbiprofen axetil was associated with a significantly lower incidence of adverse reactions in comparison to tramadol.

3.
Environ Pollut ; 260: 113996, 2020 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-31991359

RESUMO

Per-and polyfluoroalkyl substances (PFASs) are a group of chemicals with a wide range of industrial and commercial applications, but little is known about the contamination of PFASs in groundwater and their linkage to surface water. Here we investigated the occurrence of PFASs in groundwater and surface water at the Maozhou River basin in order to understand their contamination profiles and potential health risks. The results showed that total PFASs concentrations ranged from 9.9 to 592.2 ng/L, 50.2-339.9 ng/L and 3.7-74.3 ng/g in groundwater, river water and sediment, respectively. The detection frequencies of C4-C8 chains (C4-C8) PFASs were higher than C9-C14 chains PFASs in the river and groundwater. Statistical analysis showed an obvious correlation between the major contaminants in the river and those in the groundwater, indicating the potential linkage of PFASs in the groundwater to the surface water. The wastewater indicator found in groundwater suggested domestic wastewater was only one of the source for the PFASs in the river and groundwater of Maozhou River basin. Moreover, human health risk assessment showed low risks from the PFASs to the residents by drinking groundwater.

4.
Huan Jing Ke Xue ; 40(7): 3233-3241, 2019 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854723

RESUMO

This study measured the concentrations of six N-nitrosamines (NAs) in water samples from each process stage of three wastewater treatment plants (WWTPs) and their corresponding receiving rivers. The occurrence and removal of NAs was then systematically studied in three WWTPs using different treatment processes, and their pollution profiles and sources in the receiving rivers were analyzed. The results showed that the six NAs occurred widely in the wastewater from every process stage of three WWTPs. NPIP, NDMA, and NPYR were the dominant pollutants with concentrations in the tens to hundreds ng·L-1. The three WWTPs using different treatment processes removed a certain amount of NAs, and the modified A2/O and A2/O+MBR showed good NAs removal effects, with total removal rates of 95% and 63%, respectively. The removal of NAs mainly relied on microbial degradation and transformation during the biochemical stage. During the filtration, disinfection, and MBR stages, NAs precursors in the wastewater treatment system could form some added NAs after a series of reactions. The six NAs were also frequently detected in the surface waters of receiving rivers, where the main pollutants were also MDMA, NPIP, and NPYR, which was consistent with the influent of the WTTPs. The sources of NAs in the receiving rivers were wide ranging and complicated, including emission from the effluent of the WTTPs, the release of untreated sanitary sewage, industrial wastewater, and surface runoff from industrial districts. Therefore, effective measures should be taken to reduce the input of NAs into receiving rivers, such as enhancing the capacity of sewage collection and treatment and optimizing sewage treatment processes.

5.
Artigo em Inglês | MEDLINE | ID: mdl-31701358

RESUMO

A Gram-stain negative, rod-shaped, aerobic, oxidase-positive and catalase-weakly positive bacterial strain with polar or subpolar flagellum, designated RZ04T, was isolated from an intertidal sand sample collected from a coastal area of the Yellow Sea, China. The organism was observed to grow optimally at 25 °C and pH 6.5-7.0 with 2% (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain RZ04T was closely related to Colwellia asteriadis (similarity 96.9%) and Litorilituus sediminis (similarity 96.8%), and 94.4-96.4% sequence similarities to other type strains of species of the genera belonged to the family Colwelliaceae. The dominant fatty acids of strain RZ04T were determined to be C17:1ω8c, C15:1ω8c, C16:0 and summed feature 3 (C16:1ω6c and/or C16:1ω7c), and the predominant isoprenoid quinone was determined to be quinone 8 (Q-8). Phosphatidylethanolamine, phosphatidylglycerol, an unidentified aminophospholipid and four unidentified lipids were determined to be the major constituents of the polar lipids. The genome of strain RZ04T is 4.14 Mbp with a G + C content of 37.4 mol%. A total of 3631 genes are predicted, with 3531 protein-coding genes, 75 RNA genes and 25 pseudogenes. Based on phenotypic, genotypic and phylogenetic analysis, strain RZ04T is considered to represent a novel species in the genus Litorilituus, for which the name Litorilituus lipolyticus is proposed. The type strain is RZ04T (= MCCC 1K03616T = KCTC 62835T). An emended description of Colwellia asteriadis is also provided.

6.
Sci Rep ; 9(1): 15544, 2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31664141

RESUMO

The association between suboptimal pre-pregnancy body mass index (BMI) and small-for-gestational-age (SGA) infants is not well defined. We investigated the association between pre-pregnancy BMI and the risk of SGA infants in a Chinese population. We performed a cohort study among 12029 mothers with a pregnancy. This cohort consisted of pregnant women that were: normal-weight (62.02%), underweight (17.09%), overweight (17.77%) and obese (3.12%). Birth sizes were reduced in the underweight and obese groups compared with the normal-weight group. Linear regression analysis indicated that birth size was positively associated with BMI in both the underweight and normal-weight groups. Further analysis showed that 12.74% of neonates were SGA infants in the underweight group, higher than 7.43% of neonates reported in the normal-weight group (adjusted RR = 1.92; 95% CI: 1.61, 2.30). Unexpectedly, 17.60% of neonates were SGA infants in the obese group, much higher than the normal-weight group (adjusted RR = 2.17; 95% CI: 1.57, 3.00). Additionally, 18.40% of neonates were large-for-gestational-age (LGA) infants in the obese group, higher than 7.26% of neonates reported in the normal-weight group (adjusted RR = 3.00; 95% CI: 2.21, 4.06). These results suggest that pre-pregnancy underweight increases the risk of SGA infants, whereas obesity increases the risks of not only LGA infants, but also SGA infants.

7.
Ren Fail ; 41(1): 750-761, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31441362

RESUMO

Diabetic patients are more susceptible to renal ischemia/reperfusion (I/R) injury (RI/RI) and have a poor prognosis, but the underlying mechanism remains unclear. The present study aimed to examine whether diabetes could worsen acute kidney injury induced by I/R in rats and clarify its mechanism. Control and streptozotocin-induced diabetic rats were subjected to 45 min renal pedicle occlusion followed by 24 h reperfusion. Tert-butylhydroquinone (TBHQ, 16.7 mg/kg) was administrated intraperitoneally 3 times at intervals of 8 h before ischemia. Serum and kidneys were harvested after reperfusion to evaluate renal function and histological injury. Enzyme-linked immunosorbent assays were used to test pro-inflammatory cytokines. Terminal deoxynucleotidyl-transferase-mediated dUTP nick-end labeling assays were used to detect apoptotic cells, and western blotting was performed to determine the expression of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), and cleaved caspase-3, as well as oxidative stress and inflammation-related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), Toll-like receptor 4 (TLR4), and nuclear factor-κB (NF-κB). Compared with control animals, diabetic rats undergoing I/R exhibited more severe tubular damage and renal dysfunction. Diabetes exacerbated oxidative stress, the inflammatory response, and apoptosis after renal I/R by enhancing TLR4/NF-κB signaling and blocking the Nrf2/HO-1 pathway. RI/RI in diabetic rats was attenuated by pretreatment with TBHQ (a Nrf2 agonist), which exerted anti-inflammatory and anti-apoptotic properties by inhibiting NF-κB signaling. These findings indicate that hyperglycemia exacerbates RI/RI by intensifying oxidative stress, inflammation, and apoptosis. Antioxidant pretreatment may alleviate RI/RI in diabetic patients.

8.
Am J Physiol Renal Physiol ; 317(4): F852-F864, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31390235

RESUMO

Diabetes could aggravate ischemia-reperfusion (I/R) injury, but the underlying mechanism is unclear. In the present study, we aimed to investigate whether diabetes exacerbates renal I/R injury and its possible mechanism. In vitro, HK-2 cells under normal or high glucose conditions were subjected to hypoxia (12 h) followed by reoxygenation (3 h) (H/R). Cell viability, intracellular ATP content, mitochondrial membrane potential, reactive oxygen species production, and apoptosis were measured. In vivo, streptozotocin-induced diabetic and nondiabetic rats were subjected to I/R. Renal pathology, function, and apoptosis were evaluated by hematoxylin and eosin staining, transmission electron microscopy, and Western blot analysis. Compared with the normal glucose + H/R group, mitochondrial function (ATP, mitochondrial membrane potential, and reactive oxygen species) and mitophagy were reduced in the high glucose + H/R group, as was expression of phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and Parkin. Also, cells in the high glucose + H/R group exhibited more apoptosis compared with the normal glucose + H/R group, as assessed by flow cytometry, TUNEL staining, and Western blot analysis. Compared with normal rats that underwent I/R, diabetic rats that underwent I/R exhibited more severe tubular damage and renal dysfunction as well as expression of the apoptotic protein caspase-3. Meanwhile, diabetes alleviated mitophagy-associated protein expression in rats subjected to I/R, including expression of PINK1 and Parkin. Transmission electron microscopy indicated that the mitophagosome could be hardly observed and that mitochondrial morphology and structure were obviously damaged in the diabetes + I/R group. In conclusion, our results, for the first time, indicate that diabetes could aggravate I/R injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy in vivo and in vitro.

9.
Mater Sci Eng C Mater Biol Appl ; 103: 109786, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31349454

RESUMO

The purpose of our research was to verify the feasibility and effectiveness of a novel three-dimensional printed biopolymer device (3DP-BPD) for duct-to-mucosa pancreaticojejunostomy (PJ) in minipigs. Polylactic acid (PLA) was selected as the raw materials for 3DP-BPD. Three components of a 3DP-BPD were designed and manufactured: hollow stent, supporting disk, and nut. A pancreatic duct dilation model was developed in six minipigs. After 4 weeks, minipigs underwent operations with duct-to-mucosa PJ using 3DP-BPD. The operation time and postoperative complications were analyzed. The anastomotic sites were evaluated grossly 4 weeks and 24 weeks after PJ, and the histological evaluation of anastomotic sites was performed 24 weeks after PJ. The operation time of six stitches duct-to-mucosa PJ was 9.1 ±â€¯1.7 min. All minipigs survived without any adverse events like postoperative pancreatic fistula (POPF). Serum C reactive protein (CRP) and procalcitonin (PCT) levels were normal, and the anastomotic sites were connected tightly on gross observation and touch at 4 weeks and 24 weeks. Histological examinations indicated that the tissues were continuous between the pancreas and the jejunum. The use of 3DP-BPD did not increase the risk of severe local inflammation and POPF. 3DP-BPD used for duct-to-mucosa PJ is more convenient and clinically feasible for pancreatoenteric reconstruction.


Assuntos
Biopolímeros/química , Impressão Tridimensional , Stents , Animais , Proteína C-Reativa/análise , Módulo de Elasticidade , Jejuno/patologia , Pâncreas/patologia , Pâncreas/cirurgia , Fístula Pancreática/cirurgia , Pancreaticojejunostomia/efeitos adversos , Poliésteres/química , Complicações Pós-Operatórias , Suínos , Porco Miniatura , Resistência à Tração
10.
Sci Total Environ ; 683: 61-70, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31129332

RESUMO

Domestic wastewaters are an important source of endocrine disrupting chemicals in the receiving aquatic environment. Most rural domestic wastewaters (RDWs) in China have been directly discharged into the aquatic environment without any treatment. Here we studied the effects of RDWs on the western mosquitofish (Gambusia affinis) from two rural rivers receiving untreated RDWs. Mosquitofish samples were collected at 5 sampling sites along two rivers during dry and wet seasons. Sex ratios, secondary sex characteristics and transcriptional levels of target genes related to the endocrine system in adult females and males were determined. In parallel, various pollutants including steroid hormones, phenolic compounds, pesticides, polycyclic aromatic hydrocarbons (PAHs) and heavy metals were measured in the water samples at all sites. The results showed that the androgenic effects in the fish were evidenced by significant increase in male to female ratio in fish populations at two sampling sites and by the presence of modified hemal spines in females at four sampling sites when compared to the reference site. The males from the two rivers had increased Vtg mRNA expressions with a maximal 6.2-fold increase relative to the reference site and a delayed development of hemal spines. The redundancy analysis (RDA) showed that some physiological parameters were related to steroid hormones, phenolic compounds and PAHs. The findings from this study suggest that RDWs can lead to masculinization in females and feminization in males.


Assuntos
Ciprinodontiformes/metabolismo , Disruptores Endócrinos/efeitos adversos , Poluentes Químicos da Água/efeitos adversos , Animais , China , Ciprinodontiformes/genética , Disruptores Endócrinos/análise , Feminino , Proteínas de Peixes , Masculino , Rios/química , Esgotos/análise , Águas Residuárias/análise , Poluentes Químicos da Água/análise
11.
Sci Total Environ ; 665: 810-819, 2019 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-30790753

RESUMO

We used a hybrid precipitation method to simultaneously extract and analyze 24 personal care products (PCPs), including 16 biocides, 4 synthetic musks, and 4 benzotriazoles, in the plasma of fish. The method's performance was validated for plasma samples with and without ß-glucuronidase/aryl-sulfatase hydrolysis. The recoveries were in the range of 70-120% for most of the PCPs, except N,N-diethyl-3-methylbenzamide (DEET), clotrimazole (CTZ), miconazole and itraconazole at spiking concentration of 20 and 5 ng/mL. The quantification limits ranged between 0.89 and 17.9 ng/mL (hydrolyzed plasma) and 0.85-18.5 ng/mL (non-hydrolyzed plasma), except CTZ at 77.5 ng/mL and 76.3 ng/mL. Totally, 13 PCPs were detected in plasma samples of fish collected from the Yangtze River, with a maximum concentration of 58.4 ng/mL (galaxolide). Compounds with the phenol hydroxyl groups of parabens or triclosan in hydrolyzed plasma showed higher concentrations than those in unhydrolyzed plasma with the ratio of conjugation (glucuronides + sulfates) forms up to 86%. The median values for the logarithm of bioaccumulation factors were between 1.39 and 4.15, which were 2-3 orders of magnitude higher than the theoretical logarithm of bioconcentration factors. Using the fish plasma model, the effect ratios (effect concentration/measured plasma concentration ratios) of tonalide, galaxolide, benzotriazole, triclosan, and DEET reached 0.35, 4.15, 3.78, 7.52, and 9.24, respectively. These are recognized as priority chemicals for further risk assessment.


Assuntos
Cosméticos/metabolismo , Desinfetantes/metabolismo , Exposição Ambiental , Monitoramento Ambiental/métodos , Peixes/metabolismo , Poluentes Químicos da Água/metabolismo , Animais , China , Rios
12.
Eur J Gastroenterol Hepatol ; 31(5): 599-606, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30807447

RESUMO

BACKGROUND AND AIM: Emerging published data on the accuracy of γ-glutamyl transpeptidase-to-platelet ratio (GPR) for diagnosing hepatitis B virus (HBV)-related fibrosis are inconsistent. The aim of this study was to systematically review the performance of GPR for diagnosing HBV-related significant fibrosis, severe fibrosis, and cirrhosis. PATIENTS AND METHODS: A comprehensive literature search of PubMed, Web of Science, and EMBASE was conducted before July 2018. Study selection was performed according to inclusion and exclusion criteria. The relevant parameters of eligible studies were abstracted. The methodological quality was assessed according to the Quality Assessment of Diagnostic Accuracy Studies. Areas under summary receiver operating characteristic curves, sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratios were used to examine the GPR accuracy for the diagnosis of significant fibrosis, severe fibrosis, and cirrhosis. RESULTS: A total of 10 studies including 5882 patients with HBV infection underwent liver biopsy were incorporated. The prevalence of significant fibrosis, severe fibrosis, and cirrhosis were 58% (range: 22-72%), 36% (range: 10-55%), and 19% (range: 2-33%), respectively. Areas under summary receiver operating characteristic curves of GPR for predicting significant fibrosis, severe fibrosis, and cirrhosis were 0.733, 0.777, and 0.796, respectively. Subgroup analysis was performed according to geographical region and histological scoring system with similar results. CONCLUSION: GPR has moderate diagnostic accuracy for predicting HBV-related significant fibrosis, severe fibrosis, and cirrhosis, and further studies with large sample size, rigorous design, multicenter study population are urgently needed.


Assuntos
Plaquetas , Ensaios Enzimáticos Clínicos , Hepatite B/diagnóstico , Cirrose Hepática/diagnóstico , gama-Glutamiltransferase/sangue , Biomarcadores/sangue , Hepatite B/sangue , Hepatite B/epidemiologia , Hepatite B/virologia , Humanos , Cirrose Hepática/sangue , Cirrose Hepática/epidemiologia , Cirrose Hepática/virologia , Contagem de Plaquetas , Valor Preditivo dos Testes , Prevalência , Reprodutibilidade dos Testes
13.
Chemosphere ; 219: 243-249, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30543959

RESUMO

Climbazole is an antifungal agent widely used in household personal care products, and it was found persistent in chlorination disinfection process. Here we investigated the kinetics and mechanism of climbazole degradation by UV/chlorine process. The results showed that the UV/chlorine process dramatically enhanced degradation of climbazole when compared to the UV photolysis and chlorination alone. The neutral condition (pH 7) produced the highest reaction rate for the climbazole by UV/chlorine among the various pH conditions. Dissolved organic matter and inorganic ions in natural water showed moderate inhibition effects on the degradation of climbazole in the UV/chlorine process. Hydroxyl radical (OH and chlorine radical (Cl) were found to be the main reactive species in the degradation of climbazole, with the second-order rate constant of 1.24 × 1010 M-1 s-1 and 6.3 × 1010 M-1 s-1, respectively. In addition, the OH and Cl in the UV/chlorine at 100 µM accounted for 82.2% and 7.7% contributions to the removal of climbazole, respectively. Eleven of main transformation products of climbazole were identified in the UV/chlorine process. These oxidation products did not cause extra toxicity than climbazole itself. The findings from this study show that the combination of chlorination with UV photolysis could provide an effective approach for removal of climbazole during conventional disinfection process.


Assuntos
Cloro/química , Halogenação/fisiologia , Imidazóis/uso terapêutico , Poluentes Químicos da Água/metabolismo , Purificação da Água/métodos , Imidazóis/farmacologia , Cinética
14.
Zhongguo Zhong Yao Za Zhi ; 43(15): 3211-3215, 2018 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-30200720

RESUMO

The post-marketing re-evaluation of traditional Chinese medicine (TCM) is a crucial stage for drug evaluation. Due to the particularity of TCM, it is necessary to re-evaluate the effectiveness of certain Chinese medicines by studying and collecting the studies on safety of long-term/extensive populations under actual clinical application, in order to verify the effectiveness of post-marketing TCM. However, there is an absence in technical specifications for relevant clinical trials on re-evaluation of effectiveness at present. As a consequence, the preliminary technical specifications were drafted in this article, focusing on several perspectives related to the re-evaluation of post-marketing clinical effectiveness of TCM, including ethical protection, research plan formulation, real-world research methods, randomized controlled trial methods, research methods of clinical pharmacological mechanism, sublimation method of TCM theory and so on. The objective of writing this article is to provide general methodological guidance for the re-evaluation of TCM post-marketing effectiveness, so that the process and results of post-marketing re-evaluation of TCM can be more scientific and reasonable.


Assuntos
Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Vigilância de Produtos Comercializados , Projetos de Pesquisa , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
15.
Medicine (Baltimore) ; 97(33): e11748, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30113460

RESUMO

This study aims to investigate major complications or symptoms of pregnant women, causes of maternal near-miss, and issues that are relevant to severe maternal disease.A retrospective analysis was performed in the "maternal individual investigation form," which included all critical maternity patients admitted to the First Affiliated Hospital of Anhui Medical University from January 1, 2012 to September 31, 2015.A total of 14,014 pregnant patients who delivered at 28 to 42 weeks of gestation were included. Eight thousand eighty-six patients experienced complications or symptoms, and top 7 of these were postpartum hemorrhage, hypertension during pregnancy, diabetes, anemia, hepatopathy, nephroma, and connective tissue disease, of which the morbidity were 11.92%, 10.15%, 9.34%, 8.57%, 3.13%. 0.56%, and 0.55%, respectively. Delivery times, gestational weeks, and informal pregnancy examinations had significant correlation with maternal near-miss (P < .05); nevertheless, the age at pregnancy, number of pregnancies, and education were not so significant (P > .05). Two hundred sixty-five patients had severe maternal diseases (maternal near miss), and the top 5 causes for severe maternal morbidity were massive blood transfusion, thrombocytopenia, clinical feature of shock, uterus removal induced by uterus infection or bleeding, and coagulation dysfunction, of which the morbidity were 24.15%, 18.87%, 13.58%, 9.43%, and 6.79%, respectively.Delivery times, gestational weeks, and informal pregnancy examinations should be considered in maternal near miss patients. Moreover, hypertensive disorders during pregnancy, postpartum hemorrhage, anemia, thrombocytopenia, hepatopathy, and cardiopathy were the principal causes of maternal near miss. Therefore, the monitoring of these principal causes of severe maternity near miss is important for reducing the maternal morbidity and mortality.


Assuntos
Histerectomia/métodos , Morbidade/tendências , Complicações na Gravidez/epidemiologia , Resultado da Gravidez/epidemiologia , Útero/cirurgia , Adolescente , Adulto , Anemia/complicações , Anemia/epidemiologia , Grupo com Ancestrais do Continente Asiático/etnologia , Doenças do Tecido Conjuntivo/complicações , Doenças do Tecido Conjuntivo/epidemiologia , Diabetes Gestacional/epidemiologia , Feminino , Hospitalização , Humanos , Hipertensão Induzida pela Gravidez/epidemiologia , Histerectomia/estatística & dados numéricos , Mortalidade Materna/tendências , Pessoa de Meia-Idade , Mortalidade , Near Miss/estatística & dados numéricos , Near Miss/tendências , Hemorragia Pós-Parto/epidemiologia , Gravidez , Complicações na Gravidez/mortalidade , Estudos Retrospectivos , Fatores de Risco , Trombocitopenia/complicações , Trombocitopenia/epidemiologia , Útero/microbiologia , Útero/patologia , Adulto Jovem
16.
Sci Total Environ ; 624: 1023-1030, 2018 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-29929219

RESUMO

This study aimed to investigate the occurrence of 19 biocides in the aquatic environments (including runoffs) of a highly urbanized region, and then analyze the sources and ecological risks of target biocides in the river system. The investigated results showed that 19 target biocides were universally detected in surface water (17), sediment (19) and rainfall runoff (18). The tributaries of the river system were seriously contaminated by the biocides compared to the main stream. The prominent biocides in the riverine environment were methylparaben, climbazole and N,N-diethyl-3-methylbenzamide (DEET) for surface water, climbazole, triclosan and triclocarban for sediment, and DEET and carbendazim for rainfall runoff. The biocides source analysis based on the mass contribution suggested that domestic wastewater was a dominant input source for most biocides in the riverine environment, while rainfall runoff was another crucial input source for some biocides, especially for DEET and carbendazim. The ecological risk assessment revealed that some high levels biocides (e.g. clotrimazole, carbendazim, and triclosan) could pose potential ecological risks to aquatic organisms. Therefore, it is essential that some efficient measures should be taken to reduce the input of biocides to river system from different sources.

17.
Chemosphere ; 201: 644-654, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29547853

RESUMO

Androgens are one class of steroids that could cause endocrine disrupting effects in aquatic organisms. However, little information is available about androgens in wastewater treatment plants (WWTPs) with different treatment technologies. Here we investigated the occurrence, removal, and fate of fourteen natural and synthetic androgens in ten WWTPs of Guangdong province, south China. The results showed detection of ten androgens in the influents of the ten WWTPs, with concentrations up to 4650 ng/L (androsta-1,4-diene-3,17-dione). But only three androgens androsta-1,4-diene-3,17-dione, 4-androstene-3,17-dione and 17ß-boldenone were detected in the final effluents of the ten WWTPs, while six androgens androsta-1,4-diene-3,17-dione (N.D. to 43.0 ng/g), 4-androstene-3,17-dione (2.06-42.7 ng/g), epi-androsterone (N.D. to 506 ng/g), testosterone (0.29-4.24 ng/g), 17ß-boldenone (N.D. to 2.05 ng/g) and methyl testosterone (N.D. to 0.70 ng/g) were found in activated sludge. The aqueous phase removal rates for most androgens in the WWTPs exceeded 95% except for 4-androstene-3,17-dione with its removal rates varying between 79.5% and 100%. The removal of androgens in the WWTPs could be attributed mainly to biodegradation while removal by precipitation, volatilization, sludge absorption and oxidation was very limited. Eight androgens were also found in five receiving rivers. The risk quotients of some androgens (androsta-1,4-diene-3,17-dione, 4-androstene-3,17-dione, methyl testosterone, 17α-trenbolone) exceeded 1 in the receiving rivers, showing high risks to aquatic organisms. Further studies are needed to understand the origin of these high risk androgens and ecological effects.


Assuntos
Androgênios/análise , Disruptores Endócrinos/análise , Rios/química , Águas Residuárias/química , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Organismos Aquáticos/efeitos dos fármacos , China , Monitoramento Ambiental , Medição de Risco , Esgotos/química
18.
Sci Total Environ ; 621: 1093-1102, 2018 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-29054634

RESUMO

Personal care products (PCPs) are widely applied in our daily life, however, little is known about their occurrence in wild fish. We investigated the bioaccumulation and potential risks of 24 PCPs in muscle and liver tissues of wild fish collected from two large rivers of Pearl and Yangtze Rivers in China. The results showed the detection of a total of 13 PCPs including 9 biocides, 2 synthetic musks and 2 benzotriazoles in at least one type of fish tissue from 12 fish species. The compounds with high detection frequencies (>50%) in fish muscle or liver tissues were N,N-diethyl-3-methylbenzamide, carbendazim, climbazole, miconazole (MCZ), methylparaben, propylparaben, triclosan (TCS), tonalide, galaxolide (HHCB) and 5-methyl-1H-benzotriazole (5-TT). Among biocides, synthetic musks and benzotriazoles, TCS, HHCB and benzotriazole showed the maximum concentrations of 79.5ng/g wet weight (ww), 299ng/g ww and 3.14ng/g ww, respectively, in muscle tissue, while MCZ, HHCB and 5-TT showed the maximum concentrations of 432ng/g ww, 2619ng/g ww and 54.5ng/g ww, respectively, in liver tissue. The median values of logarithm of bioaccumulation factors (BAF) for the detected 13 PCPs were ranged 0.8-3.35 in muscle and 0.85-4.58 in liver. The log BAF values of the PCPs displayed good linear relationships with log Kow and log Dow (pH-dependent Kow). The health hazard assessment of 10 detected PCPs in the muscle indicated no appreciable risk to human via consumption of the wild fish.


Assuntos
Cosméticos/análise , Peixes , Poluentes Químicos da Água/análise , Animais , China , Humanos , Medição de Risco , Rios
19.
Sci Total Environ ; 616-617: 816-823, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29089128

RESUMO

We systematically investigated the occurrence and distribution of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in surface water and groundwater of Dongjiang River basin in south China. In surface water, 52 compounds were detected with median concentrations ranging from 0.06ng/L to 504ng/L, while in groundwater, 33 compounds were detected with concentrations up to 4580ng/L for acesulfame. PPCPs and ASs were widely detected in the surface water and groundwater samples, which indicated contamination by domestic wastewater in the surface water and groundwater of Dongjiang River basin. Temporal and spatial variations of the detected chemicals were observed in surface water. Acesulfame, sucralose and cyclamate can be used as wastewater indicators to imply contamination in groundwater caused by domestic wastewater due to their hydrophilicity, anthropogenic sources and ubiquity in groundwater. Moreover, the detection of the readily degradable ASs, cyclamate, was a strong indication of untreated wastewater in groundwater. Sucralose was found to be a suitable wastewater indicator to reflect domestic wastewater contamination in surface water and groundwater qualitatively and quantitatively, and it can be used to evaluate wastewater burden in surface water and groundwater of Dongjiang River basin. The wastewater burden data from this survey implied serious contamination in surface water and groundwater by domestic wastewater at Shima River, a tributary of the Dongjiang River. The findings from this study suggest that the selected labile and conservative chemicals can be used as indication of wastewater contamination for aquatic environments qualitatively and quantitatively.


Assuntos
Cosméticos/análise , Monitoramento Ambiental , Água Subterrânea/química , Preparações Farmacêuticas/análise , Edulcorantes/análise , Águas Residuárias/química , Poluentes Químicos da Água/análise , China
20.
J Clin Res Pediatr Endocrinol ; 10(1): 38-43, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-28825589

RESUMO

OBJECTIVE: To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) on neonatal birth weight. METHODS: Potential articles were identified by searching PubMed and Web of Science databases on April 30th, 2017. Using the Mantel-Haenszel random-effects or fixed-effects model, outcomes were summarized through weighted mean difference (WMD) and 95% confidence intervals (CI). Potential publication bias was tested using a funnel plot and the methods of Egger's regression and Begg's test. RESULTS: A total of eight studies were included in our meta-analysis. Six studies reported data on neonatal birth weight in ICP and control pregnancies. Pooled data from the six studies showed that the birth weight in the ICP group was significantly lighter than in the control group. The overall pooled WMD was -175 g (95% CI: -301, -48). Meanwhile, pooled data from the other two studies indicated that the birth weight in the late-onset ICP group was heavier than in the early-onset ICP group (WMD: 267 g, 95% CI: 168, 366). CONCLUSION: Neonatal birth weights in ICP pregnancies were lower than in normal pregnancies. Furthermore, early-onset ICP is associated with a lower birth weight than late-onset ICP.


Assuntos
Peso ao Nascer , Colestase Intra-Hepática , Complicações na Gravidez , Feminino , Humanos , Recém-Nascido , Gravidez
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