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1.
J Nanosci Nanotechnol ; 20(2): 719-730, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31383067

RESUMO

The efficient removal of toxic metal ions from waste water is of critical importance in environmental protection. In this study, we report the incorporation of graphene oxide (GO) into bacterial cellulose (BC) and the effect on the removal of metal ions from waste water. The as-prepared BC/GO adsorbents have a three-dimensional (3D) network structure with interconnected pores and high porosity. The adsorption capacities and efficiencies of the BC/GO adsorbents with varying GO contents were compared by using Cu2+, Cd2+, and Pb2+ as model heavy metal ions. The incorporated GO into the BC/GO adsorbents plays a critical role in removing metal ions through strong electrostatic interactions between the positive metal ions and the negative functional groups on GO. In addition, the effects of pH, contact time, adsorbent dose, and ion concentration on the adsorption behavior of the BC/GO adsorbents were investigated. The data from adsorption kinetics indicate that the adsorption of Cu2+, Cd2+, and Pb2+ on BC/GO obeys a pseudo-second-order model, while the adsorption isotherms vary with the type of metal ions. The desorption and readsorption experiments of the BC/GO adsorbents demonstrate good recyclability. It has been demonstrated that incorporating GO into BC is an effective way to improve the adsorption behavior of BC.

2.
Nanoscale ; 11(32): 15017-15022, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31385575

RESUMO

Hollow microporous nanostructures (HMNs) are powerful platforms for multiple promising applications, including energy storage, drug/gene delivery, nanoreactors/catalysis, adsorption, and separation. Herein, we report a facile one-step method to synthesize highly cross-linked organic-inorganic hybrid poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) HMNs via a salt-induced liquid-liquid separation process. The size of inner cavities can be properly tuned by modulating the concentration of the NaOH solution. The regulation mechanism of the PZS HMNs was further confirmed by encapsulating water-dispersed Pt nanoclusters into the cavities. Interestingly, the resulting yolk-shell Pt@PZS serves as nanoreactors and exhibits excellent substrate selectivity and recyclability for the catalytic oxidation of 1,3,5-trimethylbenzene.

3.
Acta Pharmacol Sin ; 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31316183

RESUMO

Abnormal wound healing by pulmonary artery smooth muscle cells (PASMCs) promotes vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Increasing evidence shows that both the mammalian target of rapamycin complex 1 (mTORC1) and nuclear factor-kappa B (NF-κB) are involved in the development of HPH. In this study, we explored the crosstalk between mTORC1 and NF-κB in PASMCs cultured under hypoxic condition and in a rat model of hypoxia-induced pulmonary hypertension (HPH). We showed that hypoxia promoted wound healing of PASMCs, which was dose-dependently blocked by the mTORC1 inhibitor rapamycin (5-20 nM). In PASMCs, hypoxia activated mTORC1, which in turn promoted the phosphorylation of NF-κB. Molecular docking revealed that mTOR interacted with IκB kinases (IKKs) and that was validated by immunoprecipitation. In vitro kinase assays and mass spectrometry demonstrated that mTOR phosphorylated IKKα and IKKß separately. Inhibition of mTORC1 decreased the level of phosphorylated IKKα/ß, thus reducing the phosphorylation and transcriptional activity of NF-κB. Bioinformatics study revealed that dipeptidyl peptidase-4 (DPP4) was a target gene of NF-κB; DPP4 inhibitor, sitagliptin (10-500 µM) effectively inhibited the abnormal wound healing of PASMCs under hypoxic condition. In the rat model of HPH, we showed that NF-κB activation (at 3 weeks) was preceded by mTOR signaling activation (after 1 or 2 weeks) in lungs, and administration of sitagliptin (1-5 mg/kg every day, ig) produced preventive effects against the development of HPH. In conclusion, hypoxia activates the crosstalk between mTORC1 and NF-κB, and increased DPP4 expression in PASMCs that leads to vascular remodeling. Sitagliptin, a DPP4 inhibitor, exerts preventive effect against HPH.

4.
Spectrochim Acta A Mol Biomol Spectrosc ; 223: 117284, 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31229902

RESUMO

In this article, a novel fluorescent probe (NRBE) for detecting H2O2 was developed using benzyl boronic ester as the H2O2-recognized group and Nile red as the matrix. The probe has several advantages, such as good selectivity, high sensitivity (LOD = 75 nM), good water solubility and emission in the near-infrared region (ex/em:585/670 nm). With the NRBE probe, the endogenous H2O2 in human hepatocellular carcinoma cells BEL-7402, was detected, and the H2O2 generated during the ischemia-reperfusion of the cells was imaged. These results show that NRBE can be applied for real-time detection of H2O2 in biological systems.

5.
Int J Cancer ; 2019 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-31111958

RESUMO

Human epidermal growth factor receptor 2 (HER2/erbB2) is a key driver and therapeutic target for breast cancer. The treatment of HER2-positive breast cancer remains a clinical challenge largely due to the limited understanding of HER2-driving oncogenic signaling and the frequent resistance to simply HER2-targeted therapy. Here, we show that the histone deacetylase inhibitor, trichostatin A (TSA), suppresses HER2-overexpressing breast cancer via upregulation of miR-146a and the resultant repression of its oncogenic targets, interleukin-1 receptor-associated kinase 1 and the chemokine receptor CXCR4. Mechanistically, histone H3K56 acetylation and deacetylation on the MIR146A promoter are catalyzed respectively by the acetyltransferase p300 and histone deacetylase 1 (HDAC1), both of which are recruited to the genomic loci by the transcription factor specificity protein 1 (Sp1). HER2 signaling phosphorylates Sp1 and induces its predominant association with HDAC1, but not p300, leading to histone hypoacetylation and silencing of MIR146A. In addition, the death receptor Fas is similarly downregulated by the aforementioned epigenetic paradigm, indicating its wide involvement in impairing tumor suppressor gene expression. Consequently, TSA synergizes with lapatinib, a tyrosine kinase inhibitor of HER2, to suppress breast cancer in vitro and in rodent models. These findings demonstrate a novel mechanism of HER2-driven carcinogenesis and suggest the applicability of combined HER2 and HDAC targeting in breast cancer therapy.

6.
Soft Matter ; 15(21): 4294-4300, 2019 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-31095159

RESUMO

Structural whiteness, stemming from biologically evolutionarily refined structures, provides inspiration for designing promising, reflectance-based materials. White beetles Goliathus goliatus, which can survive in high-temperature-equatorial forests, may suggest undiscovered new physical mechanisms for thermoregulation. Their scales' whiteness is created by the exquisite shell/hollow cylinder structure with two thermoregulatory effects, contributing to a lower equilibrium temperature of elytra under direct sunlight. In the visible regime, they enhance the broadband omnidirectional reflection significantly by synergetic structural effects originating from the thin-film interference, Mie resonance and total reflection. In the mid-infrared (MIR) regime, white scales act as antireflective layers to increase the emissivity in the MIR range, enabling the elytra to reradiate heat to the environment and help the beetles reduce their temperature by as much as ∼7.8 °C in air. These biological strategies for thermoregulation could provide new approaches for bioinspired coatings towards passive radiative cooling.


Assuntos
Besouros , Temperatura Alta , Fenômenos Ópticos , Luz Solar , Animais
7.
J Biomol Struct Dyn ; : 1-9, 2019 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-31099308

RESUMO

Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been identified as an attractive target for atherosclerosis intervention. Given potential relevance of 5-cholesten-3ß, 25-diol, 3-sulphate (CHOS) and PPARγ, an integrated docking method was used to study their interaction mechanisms, with the full considerations to distinct CHOS conformations and dynamic ensembles of PPARγ ligand-binding domain (PPARγ-LBD). The results revealed that this novel platform is satisfactory to the accurate determination of binding profiles, and the binding pattern of CHOS is rather similar as those of current PPARγ full/partial agonists. CHOS contributes to the stabilization of the AF2 and ß-sheet surfaces of PPARγ-LBD and promotes the configuration adjustment of Ω loop, in order to inhibit the Cdk5-mediated PPARγ phosphorylation. Nonetheless, there are clear differences in term of occupation of full or partial agonist-like binding models. The energetic and geometric analyses further revealed that CHOS may be fond of partial agonist-like binding, and its sulfonic group and carbon skeleton are helpful for the binding process. We hope that the results will aid our understanding of recognitions involving CHOS with PPARγ-LBD and warrant the further aspects to pharmacological experiments. Communicated by Ramaswamy H. Sarma.

8.
Molecules ; 24(2)2019 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-30641873

RESUMO

The concentrations of trace elements in wines and health risk assessment via wine consumption were investigated in 315 wines. Samples were collected from eight major wine-producing regions in China. The concentrations of twelve trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS) and Duncan's multiple range test was applied to analyze significant variations (p < 0.05) of trace elements in different regions. Based on a 60 kg adult drinker consuming 200 mL of wine per day, the estimated daily intake (EDI) of each element from wines was far below the provisional tolerable daily intake (PTDI). Health risk assessment indicated the ingestion influence of individual elements and combined elements through this Chinese wine daily intake did not constitute a health hazard to people. However, Cr and Mn were the potential contaminants of higher health risk in Chinese wines. The cumulative impact of wine consumption on trace elements intake in the daily diet of drinkers should not be ignored due to the presence of other intake pathways.


Assuntos
Medição de Risco , Análise Espectral , Oligoelementos/análise , Vinho/análise , China , Humanos , Espectrometria de Massas , Controle de Qualidade
9.
Nanomicro Lett ; 10(3): 42, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30393691

RESUMO

Uniform dispersion of two-dimensional (2D) graphene materials in polymer matrices remains challenging. In this work, a novel layer-by-layer assembly strategy was developed to prepare a sophisticated nanostructure with highly dispersed 2D graphene oxide in a three-dimensional matrix consisting of one-dimensional bacterial cellulose (BC) nanofibers. This method is a breakthrough, with respect to the conventional static culture method for BC that involves multiple in situ layer-by-layer assembly steps at the interface between previously grown BC and the culture medium. In the as-prepared BC/GO nanocomposites, the GO nanosheets are mechanically bundled and chemically bonded with BC nanofibers via hydrogen bonding, forming an intriguing nanostructure. The sophisticated nanostructure of the BC/GO leads to greatly enhanced mechanical properties compared to those of bare BC. This strategy is versatile, facile, scalable, and can be promising for the development of high-performance BC-based nanocomposite hydrogels.

10.
ChemSusChem ; 2018 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-30376216

RESUMO

Conducting polyaniline (PANI) exhibits momentous properties, such as high conductivity, reversible convertibility between redox states and advantageous structural feature and therefore receives ever-increasing attention for various applications. This paper extensively reviews recent studies on applications of polyaniline for Li-ion batteries (LIBs), Li-sulfur batteries (LSBs) and supercapacitors (SCPs). The flexible polyaniline is crucial for cyclability especially for buffering the volumetric changes of electrode materials, in addition to enhancing the electron/ions transport. Besides, polyaniline can be directly used as an electroactive component of electrode materials for LIBs or SCPs. Also it is widely applied in LSBs due to its physically and chemically strong affinity for sulfur and polysulfides. Herein, substantial studies demonstrate the significant improvements of electrochemical performance by the physical/chemical modification and incorporation of polyaniline.

11.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 34(6): 488-494, 2018 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-30236199

RESUMO

Objective To investigate the effect of the main outer membrane protein (MOMP) of Legionella on the phagocytosis and chemotaxis of RAW264.7 macrophages and explore its mechanism. Methods MOMP and RAW264.7 macrophages were cultured in vitro. The toxicity of MOMP to RAW264.7 macrophages was detected by CCK-8 assay and 50% inhibitory concentration (IC50) was determined. The RAW264.7 macrophages were treated by MOMP (1.14, 0.57, 0.28) µg/mL and the control group was established. The cells and cultivate supernatants were collected 24, 48 and 72 hours after the RAW264.7 macrophages were treated by MOMP. The phagocytic function of macrophages was detected by the neutral red phagocytosis experiment; the chemotaxis function of macrophage was examined by TranswellTM assay, and the levels of monocyte chemoattractant protein 1 (MCP-1) and interleukin 10 (IL-10) in cell culture supernatant monocytes were detected by ELISA. Real-time quantitative PCR was used to check the mRNA level of macrophage nucleotide-binding oligomerization domain 1 (NOD1), NOD2 and receptor-interacting protein 2 (RIP2). The protein levels of NOD1, NOD2 and RIP2 were detected by Western blot analysis. Results The IC50 of MOMP on RAW264.7 macrophages was 5.69 µg/mL. Compared with the control cells, MOMP treatment caused a decrease of RAW264.7 macrophage phagocytosis in a dose- and time-dependent manner. With the increase of MOMP dosage, the chemotaxis of macrophages and the secretory levels of MCP-1 and IL-10 in the cell culture supernatant increased, and peaked in 36 hours. The mRNA and protein expression levels of NOD2, RIP2 also increased, mRNA levels of NOD2 and RIP2 peaked in 12 hours, and protein levels peaked in 24 hours. Conclusion MOMP can inhibit the phagocytosis of RAW264.7 macrophages and enhance its chemotaxis function, which is related to the activation of NOD2/RIP2 signaling pathway.

12.
Sensors (Basel) ; 18(8)2018 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-30104492

RESUMO

This paper proposes two novel phase-based algorithms for the passive localization of a single source with a uniform circular array (UCA) under the case of measuring phase ambiguity based on two phase difference observation models, which are defined as the unambiguous-relative phase observation model (UARPOM) and the ambiguous-relative phase observation model (ARPOM). First, by analyzing the varying regularity of the phase differences between the adjacent array elements of a UCA, the corresponding relationship between the phase differences and the azimuth and elevation angle of the signal is derived. Based on the two phase observation models, two corresponding novel algorithms, namely, the phase integral accumulation and the randomized Hough transform (RHT), are addressed to resolve the phase ambiguity. Then, by using the unambiguous phase differences, the closed-form estimates of the azimuth and elevation angles are determined via a least squares (LS) algorithm. Compared with the existing phase-based methods, the proposed algorithms improve the estimation accuracy. Furthermore, our proposed algorithms are more flexible for the selection of an array radius. Such an advantage could be applied more broadly in practice than the previous methods of ambiguity resolution. Simulation results are presented to verify the effectiveness of the proposed algorithm.

13.
Redox Biol ; 19: 134-146, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30153650

RESUMO

Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5R F173L(hD5F173L-TG) and cardiac-specific human D5R wild-type (hD5WT-TG) transgenic mice, and H9c2 cells stably expressing hD5F173L and hD5WT. We found that cardiac-specific hD5F173L-TG mice, relative to hD5WT-TG mice, presented with DCM and increased cardiac expression of cardiac injury markers, NADPH oxidase activity, Nrf2 degradation, and activated ERK1/2/JNK pathway. H9c2-hD5F173L cells also had an increase in NADPH oxidase activity, Nrf2 degradation, and phospho-JNK (p-JNK) expression. A Nrf2 inhibitor also increased p-JNK expression in H9c2-hD5F173L cells but not in H9c2-hD5WT cells. We suggest that the D5R may play an important role in the preservation of normal heart function by inhibiting the production of reactive oxygen species, via inhibition of NADPH oxidase, Nrf2 degradation, and ERK1/2/JNK pathways.

14.
Proteins ; 86(8): 882-891, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29726048

RESUMO

Current cholesteryl ester transfer protein (CETP) inhibitors are designed based on the unglycosylated crystal structure, and most of them have failed to cure cardiovascular disease (CVD). It is particularly important for us to investigate the glycosylation structure of CETP (CETP-G) and effect of glycans on the structure and function of CETP. Here, we used a total of 3.0-µs molecular dynamics (MD) trajectories of nascent structure of CETP (CETP-N) and CETP-G to study their structural differentiations, to shed new light on the CETP-mediated lipid exchange. In accordance with our simulations and previous mutation studies, relative to CETP-N, CETP-G adopts a more stretched shape with higher hydrophobic and hydrophilic solvent-accessible surface area (SASA) of N-terminal oscillating with larger amplitude, in which Glycan88 provides partial assistance for CEs through the N-terminal. Glycan341 reduces the flexibility of neck flap, with the interference of CEs through the neck region. Besides, Glycan240 reduces the flexibility of Helix-X to interfere the CEs transfer. Glycan396 decreases the flexibility and increases the hydrophobic SASA of C-terminal. Overall, these glycans affect the dynamics and structure of CETP through forming H-bonds with surrounding residues, and the sampled conformations of glycan is also affected by its surrounding residues. Thus, glycans are an integral part of CETP, further studies on the CETP inhibition and treatment of CVD should fully consider the effect of glycans.

15.
Mol Cell ; 70(3): 531-544.e9, 2018 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-29727621

RESUMO

While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P2, a small fraction can be made by phosphorylating phosphatidylinositol-5-phosphate (PI-5-P). The physiological relevance of this second pathway is not clear. Here, we show that deletion of the genes encoding the two most active enzymes in this pathway, Pip4k2a and Pip4k2b, in the liver of mice causes a large enrichment in lipid droplets and in autophagic vesicles during fasting. These changes are due to a defect in the clearance of autophagosomes that halts autophagy and reduces the supply of nutrients salvaged through this pathway. Similar defects in autophagy are seen in nutrient-starved Pip4k2a-/-Pip4k2b-/- mouse embryonic fibroblasts and in C. elegans lacking the PI5P4K ortholog. These results suggest that this alternative pathway for PI-4, 5-P2 synthesis evolved, in part, to enhance the ability of multicellular organisms to survive starvation.

16.
Environ Entomol ; 47(4): 857-866, 2018 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-29762698

RESUMO

Atmospheric temperature increases along with increasing atmospheric CO2 concentration. This is a major concern for agroecosystems. Although the impact of an elevated temperature or increased CO2 has been widely reported, there are few studies investigating the combined effect of these two environmental factors on plant-insect interactions. In this study, plant responses (phenological traits, defensive enzyme activity, secondary compounds, defense-related gene expression and phytohormone) of Cnaphalocrocis medinalis (Guenée) (Lepidoptera: Pyralidae) -susceptible and resistant rice under various conditions (environment, soil type, variety, C. medinalis infestation) were used to examine the rice-C. medinalis interaction. The results showed that leaf chlorophyll content and trichome density in rice were variety-dependent. Plant defensive enzyme activities were affected environment, variety, or C. medinalis infestation. In addition, total phenolic content of rice leaves was decreased by elevated CO2 and temperature and C. medinalis infestation. Defense-related gene expression patterns were affected by environment, soil type, or C. medinalis infestation. Abscisic acid and salicylic acid content were decreased by C. medinalis infestation. However, jasmonic acid content was increased by C. medinalis infestation. Furthermore, under elevated CO2 and temperature, rice plants had higher abscisic acid content than plants under ambient conditions. The adult morphological traits of C. medinalis also were affected by environment. Under elevated CO2 and temperature, C. medinalis adults had greater body length in the second and third generations. Taken together these results indicated that elevated CO2 and temperature not only affects plants but also the specialized insects that feed on them.

17.
Front Pharmacol ; 9: 134, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29527168

RESUMO

Prostacyclin receptor (IP) and peroxisome proliferator-activated receptor-gamma (PPARγ) are both potential targets for treatment of pulmonary arterial hypertension (PAH). Expression of IP and PPARγ decreases in PAH, suggesting that screening of dual agonists of IP and PPARγ might be an efficient method for drug discovery. Virtual screening (VS) of potential IP-PPARγ dual-targeting agonists was performed in the ZINC database. Ten of the identified compounds were further screened, and cefminox was found to dramatically inhibit growth of PASMCs with no obvious cytotoxicity. Growth inhibition by cefminox was partially reversed by both the IP antagonist RO113842 and the PPARγ antagonist GW9662. Investigation of the underlying mechanisms of action demonstrated that cefminox inhibits the protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway through up-regulation of the expression of phosphatase and tensin homolog (PTEN, which is inhibited by GW9662), and enhances cyclic adenosine monophosphate (cAMP) production in PASMCs (which is inhibited by RO113842). In a rat model of hypoxia-induced pulmonary hypertension, cefminox displayed therapeutic efficacy not inferior to that of the prostacyclin analog iloprost or the PPARγ agonist rosiglitazone. Our results identified cefminox as a dual agonist of IP and PPARγ that significantly inhibits PASMC proliferation by up-regulation of PTEN and cAMP, suggesting that it has potential for treatment of PAH.

18.
Adv Mater ; 30(16): e1800066, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29534314

RESUMO

Smart skin is expected to be stretchable and tactile for bionic robots as the medium with the ambient environment. Here, a stretchable triboelectric-photonic smart skin (STPS) is reported that enables multidimensional tactile and gesture sensing for a robotic hand. With a grating-structured metal film as the bioinspired skin stripe, the STPS exhibits a tunable aggregation-induced emission in a lateral tensile range of 0-160%. Moreover, the STPS can be used as a triboelectric nanogenerator for vertical pressure sensing with a maximum sensitivity of 34 mV Pa-1 . The pressure sensing characteristics can remain stable in different stretching conditions, which demonstrates a synchronous and independent sensing property for external stimuli with great durability. By integrating on a robotic hand as a conformal covering, the STPS shows multidimensional mechanical sensing abilities for external touch and different gestures with joints bending. This work has first demonstrated a triboelectric-photonic coupled multifunctional sensing terminal, which may have great applications in human-machine interaction, soft robots, and artificial intelligence.

19.
J Nanosci Nanotechnol ; 18(8): 5314-5319, 2018 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-29458582

RESUMO

Compared to two-dimensional (2D) conditions, investigation on gene transfection in three-dimensional (3D) conditions is much less extensive. In this work, lamellar nano-hydroxyapatite (L-HAp) with and without magnetism were used as the vectors and gene transfection in 2D and 3D cell culture was carried out and compared. We found that the transfection efficiency in 3D conditions was much higher than 2D cell culture. Additionally, magnetism enhanced transfection efficiency under both 2D and 3D conditions. The findings presented in this study demonstrated that the magnetic L-HAp could be a promising vector in 3D gene transfection.


Assuntos
Durapatita , Nanopartículas , Transfecção , Técnicas de Cultura de Células
20.
ACS Appl Mater Interfaces ; 10(8): 7126-7133, 2018 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-29394045

RESUMO

The physical filtration mechanism of a traditional face mask has a low removal efficiency of ultrafine particulates in the size range of 10-1000 nm, which are badly harmful to human health. Herein, a novel self-powered electrostatic adsorption face mask (SEA-FM) based on the poly(vinylidene fluoride) electrospun nanofiber film (PVDF-ESNF) and a triboelectric nanogenerator (TENG) driven by respiration (R-TENG) is developed. The ultrafine particulates are electrostatically adsorbed by the PVDF-ESNF, and the R-TENG can continually provide electrostatic charges in this adsorption process by respiration. On the basis of the R-TENG, the SEA-FM shows that the removal efficiency of coarse and fine particulates is higher than 99.2 wt % and the removal efficiency of ultrafine particulates is still as high as 86.9 wt % after continually wearing for 240 min and a 30-day interval. This work has proposed as a new method of wearable air filtration and may have great prospects in human health, self-powered electronics, and wearable devices.

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