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1.
Artigo em Inglês | MEDLINE | ID: mdl-32875730

RESUMO

BACKGROUND: The ongoing coronavirus disease 2019 (COVID-19) outbreak has elicited concerns about public fear and economic fallout. The current study takes a person-oriented approach to identify the unique response patterns that underlie three risk perception components (likelihood, severity, and protection efficacy) of COVID-19, with information sources as precursors and economic confidence as outcomes. METHODS: A total of 1,074 Chinese citizens participated in a national online survey in early February 2020. RESULTS: A latent profile analysis showed that participants exhibited one of three classes: Risk Neutrals (49.9%; moderate in all components), Risk Deniers (14.3%; low likelihood, low severity, and high protection efficacy), or Risk Exaggerators (35.8%; high likelihood, high severity, and low protection efficacy). Subsequent analyses showed that reliance on unofficial sources (gossip and news spread among friends; WeChat) positively correlated with membership in the Risk Exaggerators class. In turn, belonging in the Risk Exaggerators class correlated with the lowest short-term (but not long-term) economic confidence. CONCLUSIONS: This study suggests that exploring the heterogeneity of the public risk perception might help the government to design differentiated risk communication strategies during the COVID-19 outbreak.

2.
Shock ; 2020 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-32604224

RESUMO

Sepsis-induced myocardial dysfunction (SIMD) contributes significantly to cardiovascular dysfunction during septic shock. We aimed to evaluate the potential role of Xinmailong injection (XMLI), a polypeptide medicine extracted from Periplaneta americana, in reversing the progression of myocardial damage to SIMD in sepsis patients. This was a multicenter, randomized, double-blind, parallel-group trial. We recruited all patients consecutively admitted to intensive care units (ICUs) who were aged 18-85 years old and met the sepsis 3.0 criteria. The primary outcome measure was the incidence of sepsis-induced myocardial dysfunction while in the ICU. Of the 192 patients, 96 were assigned to the treatment group, and 96 to the control group. Subsequently, 41 patients [41/96 (42.7%)] in the XMLI group and 61 patients in the placebo group [61/96 (63.5%)] were confirmed to have diastolic dysfunction on the fifth day (D5). The incidence of diastolic SIMD was significantly different between the two groups (P = 0.004). There were 36 deaths in the two groups during the 28-day follow-up, with a general mortality rate of 18.8% (36/192). The 28-day mortality rates were not significantly different between the groups (P = 0.45). However, the brain natriuretic peptide (BNP) plasma concentration trends on D0, D2, and D5 significantly differed between the two groups (P = 0.049). In septic patients, XMLI decreased the occurrence rate of diastolic SIMD more effectively than the placebo. The improvement in serum BNP concentration was also greater in the XMLI group. XMLI may, therefore, effectively and safely improve cardiac function in patients with sepsis.

3.
Artigo em Inglês | MEDLINE | ID: mdl-32517165

RESUMO

Engaging in prosocial behavior is considered an effective way to increase happiness in a sustainable manner. However, there is insufficient knowledge about the conditions under which such a happiness effect occurs. From a person-activity congruence perspective, we proposed that an individual's eudaimonic orientation moderates the effect of prosocial behavior on happiness, whereas hedonic orientation does not. For this purpose, 128 participants were assigned to play a game in which half of them were explained the benevolence impact of playing the game (the benevolence condition), and the other half played the same game without this knowledge (the control condition). Participants' eudaimonic and hedonic orientations were assessed before the game, and their post-task happiness were measured after the game. The results showed that participants in the benevolence condition reported higher post-task positive affect than those in the control condition. Furthermore, this happiness effect was moderated by participants' eudaimonic orientation-participants with high eudaimonic orientation reaped greater benefits from benevolence, and their hedonic orientation did not moderate the relationship between benevolence and happiness. The importance of the effect of person-activity congruence on happiness is discussed, along with the implications of these findings for sustainably pursuing happiness.


Assuntos
Felicidade , Orientação , Prazer/fisiologia , Comportamento Social , Comportamento , Humanos , Relações Interpessoais , Personalidade , Filosofia , Teoria Psicológica , Virtudes
4.
Chin J Integr Med ; 2020 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-32388823

RESUMO

OBJECTIVE: To study the pharmacological mechanism of Guanxin II formula (II) for treatment of coronary heart disease (CHD). METHODS: A network pharmacology-based method was utilized. First candidate compounds, targets of GX II were collected using PharmMapper, BATMAN-TCM, DrugBank and SwissTargetPrediction, and targets on CHD were mined from GeneCards, DisGenet, DrugBank and GEO. Afterwards, the big hub compounds and targets were chosen in the candidate compounds-direct therapeutic targets on the CHD (C-T) network and the direct therapeutic targets on the CHD (T-D) network. Furthermore, the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were performed to identify the enriched terms. Finally, a molecular docking simulation strategy was adopted to verify the binding capacity between the big hub compounds and big hub targets on CHD. RESULTS: First, 114 candidate compounds were selected with the following criteria: OB⩾30%, DL⩾0.18, and HL ⩾4 h. Then, 1,035 targets of GX II were gathered, while 928 targets on CHD were collected. Afterwards, 196 common targets of compound targets and therapeutic targets on CHD were defined as direct therapeutic targets acting on CHD. In addition, the contribution index (CI) in the C-T network was calculated, and 4 centrality properties, including degree, betweenness, closeness and coreness, in the T-D network, 4 big hub compounds, and 6 big hub targets were eventually chosen. Furthermore, the GO and KEGG analysis indicated that GX II acted on CHD by regulating the reactive oxygen species metabolism, steroid metabolism, lipid metabolism, inflammatory response, proliferation, differentiation and apoptosis. The docking results manifested excellent binding capacity between the 4 big hub compounds and 6 big hub targets on CHD. CONCLUSION: This network pharmacology-based exploration revealed that GX II might prevent and inhibit the primary pathological processes of CHD.

5.
PLoS One ; 13(12): e0208473, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30521616

RESUMO

We were interested in how specific cultural value and adolescent social behavior would influence each other over time. Thus the present study explored the longitudinal and bidirectional relations between adolescents' power distance value and prosocial behavior toward powerful people over a year. A sample of 434 Chinese adolescents participated in the investigation (initial mean age = 11.27; 54.15% females). The results based on cross-lagged models showed that, earlier prosocial behavior toward powerful people was positively correlated to subsequent power distance value, but not vice versa. The findings point toward an understanding of the important role of adolescent social behavior on his/her cultural value development, and also shed light on future research in terms of the interplay between cultural values and individual's social behaviors in other cultures.


Assuntos
Comportamento do Adolescente/psicologia , Comportamento Social , Adolescente , Criança , China , Cultura , Feminino , Humanos , Relações Interpessoais , Estudos Longitudinais , Masculino , Poder Psicológico
6.
J Adolesc ; 62: 162-170, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29197702

RESUMO

The present study examines the short-term changes and longitudinal relations between adolescents' materialism and prosocial behavior toward family, friends, and strangers over a year. A total of 434 Chinese adolescents (mean age at Time 1 = 11.27; 54% girls) participated in the two time points. From 6th grade to 7th grade, boys' and girls' materialism increased, whereas their prosocial behavior toward family, friends, and strangers declined, despite the stable trend in boys' prosocial behavior toward strangers. Furthermore, a cross-lagged model was conducted and the results showed that, adolescent materialism was associated longitudinally with decreased prosocial behavior toward friends and strangers, but not toward family. However, earlier prosocial behavior toward family, friends, and strangers were not associated with subsequent adolescent materialism. The findings point toward an understanding of materialism as a precursor rather than an outcome or byproduct to prosocial behavior.


Assuntos
Comportamento do Adolescente/psicologia , Relações Interpessoais , Comportamento Social , Adolescente , Grupo com Ancestrais do Continente Asiático , Criança , Compreensão , Família , Feminino , Amigos , Humanos , Estudos Longitudinais , Masculino
7.
Shock ; 48(2): 168-174, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28187039

RESUMO

BACKGROUND: Neutrophil elastase (HNE) is a destructive enzyme and plays crucial roles in the pathophysiology of acute respiratory distress syndrome (ARDS). Endogenous proteinase inhibitors elafin (PI3) is important to protect against lung tissue destruction. We proposed to examine whether HNE and PI3 serve as prognostic biomarkers for ARDS. METHODS: This study is a survival and longitudinal analysis of plasma profiles of HNE and PI3 in ARDS patients from a multicenter prospective observational cohort in Beijing, China. Plasma samples were collected on day-1, day-3, and day-7 of study enrollment. RESULTS: HNE levels were higher in ARDS non-survivors than survivors, whereas PI3 showed opposite direction for all three measurements (P < 0.01 for all). Patients with HNE level above median and PI3 level below median values had the lowest survival probability and died the fastest. There was a significant longitudinal effect of HNE levels and PI3 level on mortality. Receiver-operating characteristic analysis demonstrated combination of HNE and PI3 had the discrimination ability for 28-day mortality (area under the receiver-operating characteristic curve [AUC]: 0.76), better than the combination of Berlin categories and APACHE II (AUC: 0.63). The addition of HNE and PI3 to Berlin categories and APACHE II has significantly improved the prognostic discrimination ability (AUC: 0.81, P < 0.0001). CONCLUSIONS: Imbalance between HNE and PI3 levels in ARDS patients was associated with ARDS mortality. By combining these biomarkers with Berlin categories and APACHE II, prognostic power of ARDS was greatly improved. Circulation levels of HNE and PI3 may have the potential to predict ARDS mortality and better inform clinicians about ARDS mortality risk.


Assuntos
Elafina/sangue , Elastase de Leucócito/sangue , /mortalidade , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Taxa de Sobrevida
8.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 26(11): 773-9, 2014 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-25399889

RESUMO

OBJECTIVE: To explore the risk factors of the occurence and 28-day death of acute respiratory distress syndrome (ARDS) in intensive care unit (ICU). METHODS: A prospective multicentral cohort study was conducted. The patients from five ICUs of grade A tertiary hospitals in Beijing from July 2009 to March 2014, including sepsis, septic shock, trauma, pneumonia, aspiration, massive blood transfusion, bacteremia and pulmonary contusion, were enrolled. Researchers in each center reported the records with uniform tables, which included demographic, systemic conditions, the primary disease, and the severity within 24 hours, past history and so on. According to the admission diagnosis in ICU, these patients were divided into ARDS group and other severe disease control group. The risk factors of occurence and prognosis of ARDS were analyzed by univariate analysis, multivariate logistic regression and multivariate COX regression analysis. Kaplan-Meier method was applied to draw the 28-day survival curves of the two groups. RESULTS: There were 343 critical patients included in this prospective multicenter cohort study, of which 163 patients who developed ARDS were considered as ARDS group (2 case lost to follow-up, and 49 died) and 180 patients who did not developed ARDS regarded as severe control group (1 case lost to follow-up, and 34 died). The 28-day mortality of ARDS group was significantly higher than that of severe control group [30.43% (49/161) vs. 18.99% (34/179), χ² = 6.013, P = 0.014]. Multivariate logistic analysis showed that aspiration [odds ratio (OR) = 6.390, 95% confidence interval (95% CI) =2.046-19.953, P = 0.001], history of alcohol (OR=4.854, 95% CI = 1.730-13.617, P = 0.003), sepsis (OR = 2.859, 95% CI=1.507-5.425, P = 0.001), pneumonia (OR = 2.822, 95% CI = 1.640-4.855, P<0.001), acute physiology and chronic health evaluation II (APACHEII) score (OR=1.050, 95%CI=1.007-1.094, P=0.022) were significantly associated with increased risk of ARDS occurence. When respiratory rate>30 beats/min (OR=3.305, 95%CI = 1.910-5.721, P<0.001), heart rate>100 beats/min (OR = 2.101, 95% CI = 1.048-4.213, P = 0.037) happened in critically ill patients, it highly suggested ARDS would happen. The proportion of the patients whose serum creatinine>176.8 µmol/L in ARDS group was lower than that in control group (OR = 0.387, 95% CI = 0.205-0.733, P = 0.004). Multivariate COX regression analysis showed that old age and septic shock were significantly associated with the increased risk of in 28-day death of ARDS [advanced age: hazard ratio (HR)=1.040, 95%CI=1.018-1.064, P<0.001; septic shock: HR=3.209, 95% CI = 1.676-6.146, P<0.001]. Kaplan-Meier showed that the survival patients in ARDS group was significantly lower than those in severe control group (χ² = 7.032, P = 0.008). CONCLUSIONS: Among critical ill patients, aspiration, history of alcohol, sepsis, pneumonia, increased APACHEII score were the risk factors of ARDS development. Respiratory rate>30 beats/min and heart rate>100 beats/min could predict the occurrence of ARDS in critical patients. Old age and septic shock were the risk factors of 28-day death of ARDS.


Assuntos
Mortalidade Hospitalar , Unidades de Terapia Intensiva/estatística & dados numéricos , /epidemiologia , Distribuição por Idade , Idoso , China/epidemiologia , Intervalos de Confiança , Estado Terminal , Humanos , Modelos Logísticos , Prognóstico , Estudos Prospectivos , Fatores de Risco , Choque Séptico
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