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1.
J Abnorm Psychol ; 130(8): 807-814, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34843287

RESUMO

Prospection refers to the ability to mentally construct future events, which is closely related to motivation and anhedonia. The neural underpinning of impaired prospection in psychiatric populations remains unclear. We recruited 34 individuals with autistic traits (AT), 27 individuals with schizotypal traits (ST), 31 individuals with depressive symptoms (DS), and 35 controls. Participants completed a prospection task while undergoing functional Magnetic Resonance Imaging (MRI). We found that regions of the "default mode network" including the medial frontal gyrus, the posterior cingulate cortex, the precuneus and the parahippocampus were activated; and regions of the "task-positive network" including the inferior parietal lobe, the inferior frontal gyrus and the precentral gyrus were deactivated during prospection in controls. Compared with controls, AT, ST, and DS showed comparable behavioral performance on prospection. However, reduced activation in anterior cingulate cortex and frontal gyrus was found in AT individuals relative to controls during prospection. ST individuals showed hyperactivation in the caudate relative to controls when processing positive emotion, while DS individuals and controls showed similar neural responses during prospection. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

2.
Psychol Med ; : 1-9, 2021 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-33775271

RESUMO

BACKGROUND: Anticipatory pleasure deficits are closely correlated with negative symptoms in schizophrenia, and may be found in both clinical and subclinical populations along the psychosis continuum. Prospection, which is an important component of anticipatory pleasure, is impaired in individuals with social anhedonia (SocAnh). In this study, we examined the neural correlates of envisioning positive future events in individuals with SocAnh. METHODS: Forty-nine individuals with SocAnh and 33 matched controls were recruited to undergo functional MRI scanning, during which they were instructed to simulate positive or neutral future episodes according to cue words. Two stages of prospection were distinguished: construction and elaboration. RESULTS: Reduced activation at the caudate and the precuneus when prospecting positive (v. neutral) future events was observed in individuals with SocAnh. Furthermore, compared with controls, increased functional connectivity between the caudate and the inferior occipital gyrus during positive (v. neutral) prospection was found in individuals with SocAnh. Both groups exhibited a similar pattern of brain activation for the construction v. elaboration contrast, regardless of the emotional context. CONCLUSIONS: Our results provide further evidence on the neural mechanism of anticipatory pleasure deficits in subclinical individuals with SocAnh and suggest that altered cortico-striatal circuit may play a role in anticipatory pleasure deficits in these individuals.

3.
Schizophr Bull ; 46(2): 442-453, 2020 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-31355879

RESUMO

A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.


Assuntos
Imagem de Tensor de Difusão/métodos , Rede Nervosa/patologia , Transtorno Obsessivo-Compulsivo/patologia , Esquizofrenia/patologia , Máquina de Vetores de Suporte , Substância Branca/patologia , Adolescente , Adulto , Comorbidade , Feminino , Humanos , Masculino , Rede Nervosa/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/epidemiologia , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/epidemiologia , Substância Branca/diagnóstico por imagem , Adulto Jovem
4.
Schizophr Res ; 215: 322-329, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31611042

RESUMO

BACKGROUND: Affective forecasting, or the ability to forecast emotional responses to future events, is essential to everyday life adaption. Previous research suggests that individuals with social anhedonia exhibit deficits in affective forecasting, but the pattern of these deficits and their neural correlates are not known. METHODS: Individuals with social anhedonia (n = 40) and healthy controls (n = 46) completed a social affective forecasting task and underwent resting-state fMRI scanning. RESULTS: Compared with healthy controls, social anhedonia individuals anticipated reduced pleasure especially in social conditions and their prospection contained less visualization, voice, taste, self-referential thoughts, other-referential thoughts and language communication. Moreover, anticipated pleasure (valence and arousal for positive events) was positively associated with effort level, especially in social conditions. The social anhedonia group also exhibited stronger functional connectivity between the retrosplenial cortex and the insula and reduced functional connectivity between the hippocampal formation and the parahippocampus. These altered functional connectivities were correlated with anticipated valence in social, but not non-social, conditions. CONCLUSIONS: These findings suggest that individuals with social anhedonia anticipate less pleasure predominately in social conditions and impaired prospection may contribute to the reduced anticipated pleasure. Reduced anticipated pleasure may be a target to improve social motivation in social anhedonia individuals.


Assuntos
Sintomas Afetivos/fisiopatologia , Anedonia/fisiologia , Antecipação Psicológica/fisiologia , Córtex Cerebral/fisiopatologia , Conectoma , Emoções/fisiologia , Imaginação/fisiologia , Comportamento Social , Interação Social , Pensamento/fisiologia , Adolescente , Adulto , Sintomas Afetivos/diagnóstico por imagem , Córtex Cerebral/diagnóstico por imagem , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Adulto Jovem
5.
Psych J ; 9(2): 223-233, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31845536

RESUMO

Investigating the relationship between anticipatory pleasure deficits and risk features of mental disorders not only theoretically benefits the understanding of anhedonia, but could also facilitate early detection and intervention of mental disorders. Using network analysis, the present study examined the pattern of relationship between anticipatory pleasure and risk features of schizophrenia spectrum, depressive, anxiety, autism spectrum, and obsessive-compulsive disorders in a large sample of college students (n = 2152). It was found that interpersonal features of schizotypal personality traits and poor social skills of autistic traits showed strong correlation with low social anticipatory pleasure. Depressive symptoms severity was weakly associated with reduced abstract anticipatory pleasure, while obsessive-compulsive traits were weakly associated with high contextual anticipatory pleasure. No significant correlation was found between anxiety symptoms severity and anticipatory pleasure. Social anticipatory pleasure had the highest strength centrality among all anticipatory pleasure components, while interpersonal features of schizotypal personality traits had the highest strength centrality in the whole network. Our findings suggest that impaired anticipatory pleasure, especially social anticipatory pleasure, is a particular feature of schizotypal personality traits and autistic traits. Our findings may have implications for intervention in that the social component may be a target to improve anhedonia in individuals with schizotypal and autistic traits, while interpersonal features may be a key treatment target given that it was central to the relationship between anticipatory pleasure and risk features.


Assuntos
Metanálise em Rede , Prazer , Estudantes/estatística & dados numéricos , Universidades , Adulto , Ansiedade , China , Feminino , Humanos , Masculino , Fatores de Risco
6.
Psychiatry Res Neuroimaging ; 293: 110987, 2019 11 30.
Artigo em Inglês | MEDLINE | ID: mdl-31629132

RESUMO

Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.


Assuntos
Memória de Curto Prazo/fisiologia , Esquizofrenia/fisiopatologia , Feminino , Substância Cinzenta/diagnóstico por imagem , Substância Cinzenta/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Transtornos da Memória/diagnóstico por imagem , Transtornos da Memória/fisiopatologia , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/fisiopatologia , Esquizofrenia/diagnóstico por imagem
7.
Asian J Psychiatr ; 44: 209-216, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31419738

RESUMO

Schizotypal personality (SP) traits have been found to be correlated with autistic traits, obsessive-compulsive traits, depressive symptoms and anxiety symptoms. However, the overall pattern of the relationship remains unclear. The purpose of this study was to investigate the network structure between SP traits and other subclinical features (symptoms or traits) and test the replicability of these relationships. A total of 2204 college students completed measurements for SP traits, autistic traits, obsessive-compulsive traits, depressive symptoms and anxiety symptoms, and a validated subsample of 814 completed the same questionnaires again three months later. Using network analysis, we constructed the network structure of subclinical features and then tested its replicability. We found that interpersonal features were the bridge node connecting SP traits and autistic traits (social skill: r = 0.50; attention switching: r = 0.14; communication: r = 0.12), while cognitive-perceptual (obsessing: r = 0.05; neutralizing: r = 0.06) and disorganization (obsessing: r = 0.11) features were the SP traits associated with obsessive-compulsive traits. In addition to interpersonal features (r = 0.10), disorganization (r = 0.12) and cognitive-perceptual (r = 0.05) features were also the overlap between depressive symptoms and SP traits. Anxiety symptoms only connected with interpersonal (r = 0.05) but not cognitive-perceptual features of SP traits. The network showed high predictability (43%) and interpersonal features of SP traits had the highest expected influence (1.67) among all nodes, which may be a potential target for intervention. High similarities were found on network structure (r = 0.86) and expected influence (r = 0.96), and no significant difference on global connectivity was found between these two networks (difference value = 0.45, p = 0.135), suggesting the replicability of the network structure.


Assuntos
Ansiedade/fisiopatologia , Transtorno do Espectro Autista/fisiopatologia , Disfunção Cognitiva/fisiopatologia , Depressão/fisiopatologia , Relações Interpessoais , Modelos Estatísticos , Transtorno Obsessivo-Compulsivo/fisiopatologia , Transtorno da Personalidade Esquizotípica/fisiopatologia , Adulto , China , Feminino , Humanos , Masculino , Estudantes , Universidades , Adulto Jovem
8.
Artigo em Inglês | MEDLINE | ID: mdl-30822447

RESUMO

BACKGROUND: Prospection, which is closely related to negative symptoms in patients with schizophrenia, is mainly associated with the Default Mode Network (DMN). Although abnormalities of the DMN have been reported in schizophrenia patients and at-risk individuals, little is known about the relationship between functional connectivity of the DMN and prospection in these clinical and subclinical populations. METHOD: Study 1 recruited 40 schizophrenia patients and 29 healthy controls, while 31 individuals with social anhedonia (SocAhn) and 28 controls participated in Study 2. Participants in both studies were asked to complete a prospection task and underwent resting-state functional MRI scans. Eleven regions of interest (ROIs) in the DMN were defined. Functional connectivity between each ROI and whole brain voxels were calculated and compared between groups (schizophrenia vs. control and SocAhn vs. control). Correlation analysis was conducted between altered functional connectivity and prospection variables in the schizophrenia and SocAhn groups. RESULTS: Schizophrenia patients showed both hyper-connectivity and hypo-connectivity at the medial temporal lobe (MTL) subsystem of the DMN. Decreased connectivity between the ventral medial prefrontal cortex (vMPFC) and the right superior temporal gyrus (rSTG) was correlated with poor thought/emotion details in prospection. In individuals with SocAhn, decreased connectivity between the retrosplenial cortex (Rsp), a region of the MTL subsystem, and the right fusiform gyrus, was found and this was correlated with their prospection performance. CONCLUSION: Altered functional connectivity of the key nodes of the MTL subsystem was found in both patients with schizophrenia and individuals with SocAhn. Moreover, hypo-connectivity of the vMPFC was found to be correlated with prospection impairments in schizophrenia patients.


Assuntos
Anedonia/fisiologia , Vias Neurais/fisiopatologia , Córtex Pré-Frontal/fisiopatologia , Esquizofrenia/fisiopatologia , Lobo Temporal/fisiopatologia , Adulto , Estudos de Casos e Controles , Feminino , Neuroimagem Funcional , Humanos , Imageamento por Ressonância Magnética , Masculino , Adulto Jovem
9.
Schizophr Bull ; 45(1): 199-210, 2019 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-29365198

RESUMO

Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.


Assuntos
Encéfalo/fisiopatologia , Conectoma/métodos , Rede Nervosa/fisiopatologia , Transtorno Obsessivo-Compulsivo/fisiopatologia , Esquizofrenia/fisiopatologia , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Comorbidade , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Rede Nervosa/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/epidemiologia , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/epidemiologia , Adulto Jovem
10.
J Abnorm Psychol ; 127(7): 710-721, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30335440

RESUMO

Previous research has revealed anticipatory pleasure deficits in people with schizophrenia and people with social anhedonia but who do not have schizophrenia. Prospection is an important component of anticipatory pleasure, but little is known about the role of prospection in social anhedonia. In 2 studies, we investigated prospection and anticipatory pleasure in people with schizophrenia and people with social anhedonia using an affective prospection task and a self-report measure, the Temporal Experience of Pleasure Scale (TEPS). In Study 1, we found that people with schizophrenia (n = 31) reported less TEPS anticipatory pleasure, generated less rich and vivid prospections, and reported less preexperiencing of future events than people without schizophrenia (n = 29). In Study 2, we found that people with social anhedonia (n = 34) reported less TEPS anticipatory pleasure, generated less rich prospections, and reported less pleasure and preexperiencing for future events than people without social anhedonia (n = 33). Taken together, prospection impairments and decreased anticipatory pleasure were observed in schizophrenia and social anhedonia. (PsycINFO Database Record (c) 2018 APA, all rights reserved).


Assuntos
Anedonia , Antecipação Psicológica , Prazer , Psicologia do Esquizofrênico , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Autorrelato
11.
Psych J ; 7(4): 239-247, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30259698

RESUMO

Future-oriented coping is a strategy for coping with events that may happen in the future, including efforts to ensure positive outcome and protection from potential threats. Appropriate future-oriented coping is essential for well-being and influences mental health and life satisfaction. However, little is known about the neural mechanism of future-oriented coping. We examined the neural basis of this coping strategy using resting-state functional connectivity analysis. Thirty healthy volunteers underwent resting-state functional magnetic resonance imaging scanning and completed the Future-Oriented Coping Inventory. Seed-based functional connectivity analysis was used to investigate potentially correlated regions, with 11 nodes in the default mode network defined as regions of interest. Multiple regression analysis was performed to measure the correlation between coping behavior and functional connectivity. We found that proactive coping was significantly correlated with the functional connectivity strength between the parahippocampal cortex (PHC) and the claustrum/insula. These novel findings suggest that cooperation between the PHC and the claustrum/insula plays an important role in proactive coping. Moreover, cognitive components, such as future thinking (the PHC) and sensory judgment (the claustrum/insula) could be important process factors in proactive coping.


Assuntos
Adaptação Psicológica/fisiologia , Mapeamento Encefálico , Previsões , Vias Neurais , Descanso/fisiologia , Feminino , Neuroimagem Funcional/métodos , Voluntários Saudáveis , Hong Kong , Humanos , Masculino , Inquéritos e Questionários , Adulto Jovem
12.
Schizophr Res ; 202: 248-253, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29996973

RESUMO

OBJECTIVE: The present study aimed to validate a severity cut-off of negative symptoms for persistent negative symptoms (PNS) identification using the Clinical Assessment Interview for Negative Symptoms (CAINS). METHOD: A total of 206 patients with schizophrenia were recruited and divided into the PNS group (n = 57) and the Non-PNS group (n = 149) using PNS criteria based on the SANS and the SAPS. To determine the appropriate cut-offs on the CAINS in identifying PNS, Receiver Operating Characteristic (ROC) curve analysis was conducted in the PNS and Non-PNS groups. RESULTS: Our results showed that the cutoffs for identifying PNS on the CAINS total score, the Motivation and Pleasure (MAP) subscale score and the Expression (EXP) subscale score were 25, 17, and 5 respectively. Area Under the Curve (AUC) analysis indicated excellent discrimination of the PNS group from the Non-PNS group using the cut-off for the CAINS total score. However, discrimination was somewhat better for the MAP subscale score than the EXP subscale score. The Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of the MAP subscale were 81.54% and 97.16%. CONCLUSION: We found that the cut-off scores derived from the CAINS to identify PNS are comparable to existing scales. The CAINS offers an alternative means in identifying PNS patients in clinical trials that overcomes methodological and conceptual limitations of older scales.


Assuntos
Esquizofrenia/diagnóstico , Adulto , Feminino , Humanos , Entrevista Psicológica , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Curva ROC , Esquizofrenia/tratamento farmacológico , Psicologia do Esquizofrênico
13.
Schizophr Res ; 201: 137-144, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29804927

RESUMO

Anhedonia in schizophrenia has been suggested to comprise a set of low-pleasure beliefs, defined as beliefs that certain things/activities were not pleasurable or that one does not feel pleasant generally. However, no instrument has been intentionally developed to specifically measure low-pleasure beliefs, and there is a paucity of empirical evidence for low-pleasure beliefs and their relationship with anhedonia in both patients with schizophrenia and individuals with high social anhedonia. We developed and validated the Beliefs About Pleasure Scale (BAPS) using non-clinical (Studies 1, 2 & 3), chronic schizophrenia (Study 2), and first episode schizophrenia (Study 3) samples. Across these studies, we examined psychometric properties of the BAPS, including temporal stability, internal consistency, factor structure, and convergent validity. The 22 BAPS items loaded onto 4 factors, namely the "Devaluation of Pleasure", the "Pleasurable Activity Expectancies", the "Negative Outcomes Expectancies", and the "Attention to Pleasure". The measure demonstrated good internal consistency and convergent validity in each sample. Moreover, both individual with schizophrenia and non-clinical participants with high social anhedonia scored higher on the BAPS than controls (Study 3), supporting construct validity. These findings provide preliminary evidence for the presence of low-pleasure beliefs in both clinical and subclinical groups and suggest that the BAPS has promising initial psychometric properties. The BAPS will be useful for exploring the cognitive component of anhedonia and provides a novel assessment for mechanism of change in psychosocial treatment studies.


Assuntos
Anedonia , Prazer , Psicologia do Esquizofrênico , Adolescente , Adulto , Cultura , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Psicometria , Reprodutibilidade dos Testes , Esquizofrenia/diagnóstico , Adulto Jovem
14.
Psychiatry Res Neuroimaging ; 276: 65-72, 2018 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-29628272

RESUMO

Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.


Assuntos
Cerebelo/diagnóstico por imagem , Córtex Cerebral/diagnóstico por imagem , Substância Cinzenta/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Estudos de Casos e Controles , Cerebelo/patologia , Córtex Cerebral/patologia , Comorbidade , Feminino , Lobo Frontal/diagnóstico por imagem , Lobo Frontal/patologia , Substância Cinzenta/patologia , Giro do Cíngulo/diagnóstico por imagem , Giro do Cíngulo/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Córtex Motor/patologia , Transtorno Obsessivo-Compulsivo/epidemiologia , Tamanho do Órgão , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/patologia , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/patologia , Esquizofrenia/epidemiologia , Lobo Temporal/diagnóstico por imagem , Lobo Temporal/patologia , Tálamo/diagnóstico por imagem , Tálamo/patologia , Adulto Jovem
15.
Psych J ; 7(2): 59-67, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29431282

RESUMO

The Temporal Experience of Pleasure Scale (TEPS) is a self-report instrument that assesses pleasure experience. Initial scale development and validation in the United States yielded a two-factor solution comprising anticipatory and consummatory pleasure. However, a four-factor model that further parsed anticipatory and consummatory pleasure experience into abstract and contextual components was a better model fit in China. In this study, we tested both models using confirmatory factor analysis in an American and a Chinese sample and examined the configural measurement invariance of both models across culture. We also examined the temporal stability of the four-factor model in the Chinese sample. The results indicated that the four-factor model of the TEPS was a better fit than the two-factor model in the Chinese sample. In contrast, both models fit the American sample, which also included many Asian American participants. The four-factor model fit both the Asian American and Chinese samples equally well. Finally, the four-factor model demonstrated good measurement and structural invariance across culture and time, suggesting that this model may be applicable in both cross-cultural and longitudinal studies.


Assuntos
Americanos Asiáticos/estatística & dados numéricos , Prazer , Psicometria/instrumentação , Psicometria/normas , Adolescente , Adulto , China/etnologia , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Estados Unidos/etnologia , Adulto Jovem
16.
Psych J ; 7(1): 25-30, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29235253

RESUMO

This study examined the factor structure of the Chinese version of the Dysexecutive Questionnaire (DEX) in a large nonclinical sample of college students (n = 1,586). All participants completed the self-report version of the DEX. An exploratory factor analysis was first performed on a sub-sample (randomly split, n = 766) and produced a four-factor model (Volition, Intentionality, Inhibition, and Abstract Problem-Solving), which was similar to previous models reported in Western samples. In addition, a series of confirmatory factor analyses was conducted on the remaining sample (n = 820). The findings suggested that a four-factor solution of the self-report DEX might better explain the latent structure in the present healthy Chinese sample.


Assuntos
Função Executiva , Análise Fatorial , Inquéritos e Questionários , Adolescente , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Psicometria/estatística & dados numéricos , Autorrelato
17.
Psychol Med ; 48(9): 1474-1483, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29017618

RESUMO

BACKGROUND: The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion-behaviour decoupling. However, a few studies have examined emotion-behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects. METHODS: In this study, we examined the nature and extent of emotion-behaviour decoupling in in three independent samples (65 schizophrenia patients v. 63 controls; 40 unaffected relatives v. 45 controls; and 32 individuals with social anhedonia v. 32 controls). We administered an experimental task to examine their affective experience and its coupling with behaviour, using emotion-inducing slides, and allowed participants to alter stimulus exposure using button-pressing to seek pleasure or avoid aversion. RESULTS: Schizophrenia patients reported similar affective experiences as their controls, while their unaffected relatives and individuals with high levels of social anhedonia exhibited attenuated affective experiences, in particular in the arousal aspect. Compared with their respective control groups, all of the three groups showed emotion-behaviour decoupling. CONCLUSIONS: Our findings support that both genetically and behaviourally high-risk groups exhibit emotion-behaviour decoupling. The familial association apparently supports its role as a putative trait marker for schizophrenia.


Assuntos
Anedonia , Emoções , Motivação , Esquizofrenia/fisiopatologia , Transtorno da Personalidade Esquizotípica/fisiopatologia , Adulto , Pequim , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prazer , Autorrelato
18.
Schizophr Res ; 195: 396-401, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-28869096

RESUMO

BACKGROUND: Emotion deficits may be the basis of negative symptoms in schizophrenia patients and they are prevalent in these patients. However, inconsistent findings about emotion deficits in schizophrenia suggest that there may be subtypes. AIM: The present study aimed to examine and profile experiential pleasure, emotional regulation and expression in patients with schizophrenia. METHODS: A set of checklists specifically capturing experiential pleasure, emotional regulation, emotion expression, depressive symptoms and anhedonia were administered to 146 in-patients with schizophrenia and 73 demographically-matched healthy controls. Psychiatric symptoms and negative symptoms were also evaluated by a trained psychiatrist for patients with schizophrenia. RESULTS: Two-stage cluster analysis and discriminant function analysis were used to analyze the profile of these measures in patients with schizophrenia. We found a three-cluster solution. Cluster 1 (n=41) was characterized by a deficit in experiential pleasure and emotional regulation, Cluster 2 (n=47) was characterized by a general deficit in experiential pleasure, emotional regulation and emotion expression, and Cluster 3 (n=57) was characterized by a deficit in emotion expression. Results of a discriminant function analysis indicated that the three groups were reasonably discrete. CONCLUSION: The present findings suggest that schizophrenia patients can be classified into three subtypes based on experiential pleasure, emotional regulation and emotion expression, which are characterized by distinct clinical representations.


Assuntos
Anedonia/fisiologia , Depressão/etiologia , Prazer/fisiologia , Esquizofrenia/complicações , Psicologia do Esquizofrênico , Adulto , Antecipação Psicológica , Análise por Conglomerados , Depressão/diagnóstico , Análise Discriminante , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Autorrelato
19.
Sci Rep ; 6: 35481, 2016 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-27752140

RESUMO

Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia. Fifteen individuals with social anhedonia were recruited and received 20 sessions of training on a dual n-back task, five sessions a week. Functional imaging paradigms of the Monetary Incentive Delay (MID) and the Affective Incentive Delay (AID) tasks were administered both before and after the training to evaluate the neural transfer effects on hedonic processing ability. Enhanced brain activations related to anticipation were observed at the anterior cingulate cortex, the left dorsal striatum and the left precuneus with the AID task, and at the dorsolateral prefrontal cortex and the supramarginal gyrus with the MID task. The present findings support that WM training may improve monetary-based and affective-based hedonic processing in individuals with social anhedonia.


Assuntos
Anedonia , Memória de Curto Prazo , Encéfalo/fisiopatologia , Mapeamento Encefálico , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Aprendizagem , Imageamento por Ressonância Magnética , Masculino , Psicologia do Esquizofrênico , Comportamento Social , Estudantes
20.
Psychiatry Res ; 245: 482-490, 2016 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-27639163

RESUMO

Anhedonia is a core feature of the negative symptoms of schizophrenia and is less responsive to antipsychotic medication. Little is known whether anhedonia could be alleviated by cognitive training. The present study aimed to examine whether hedonic deficits observed in individuals with high social anhedonia could be reduced by working memory (WM) training. Thirty-four individuals with high social anhedonia were randomly assigned to either a WM training group or a control group. The WM training group received 20 sessions of dual n-back task training for four weeks. The affective incentive delay task was administered in all participants before the training and one month later. The results showed that individuals who received the WM training showed significant improvement in WM performance (F(19, 304)=55.80, p<0.001) and they also showed significant improvement in approach sensitivity to rewards (p=0.004). These preliminary findings suggest that hedonic processing could be improved through WM training in individuals with high social anhedonia. These results may have important implications for the development of non-pharmacological interventions to alleviate anhedonia in patients with schizophrenia.


Assuntos
Anedonia , Terapia Cognitivo-Comportamental/métodos , Memória de Curto Prazo , Esquizofrenia/terapia , Psicologia do Esquizofrênico , Adulto , Afeto/fisiologia , Feminino , Humanos , Masculino , Motivação , Recompensa
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