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1.
Soft Matter ; 15(34): 6867-6877, 2019 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-31411231

RESUMO

In this study, a two-component lattice Boltzmann method (TLBM) in combination with a discrete element approach (DEA) based on a representative volume element (RVE) with respect to a bidisperse magnetorheological fluid (MRF) was performed to simulate the behavior and microstructure formation of magnetic particles in a carrier liquid. The bidisperse MRF reported herein is a suspension dispersed by soft micron carbonyl iron (CI) particles and Fe3O4 nanoparticles dual-coated with gelatin and multi-walled carbon nanotubes (MWCNTs) in the carrier liquid. In the TLBM of two-component liquid and particle simulation, the inter-particle interactions were completely ignored; on the other hand, the DEA was just employed for calculating the dynamic behavior of particles. Therefore, due to the explicit nature of the combination of TLBM and DEA, it is a more efficient and accurate strategy for the simulation and calculation of complex MRF systems. Moreover, the immersed boundary method (IBM) was used to describe the interactions between the magnetic particles and the carrier liquid. The RVE of the bidisperse MRF was selected to eliminate specific operational conditions and reduce the calculation costs. New numerical results were obtained for the motion velocities, microstructure evolution and kinetic energy of bidisperse magnetic particles (BMPs) under the effect of a magnetic field; when the mass fraction of the nanoparticles was 0.1, the bidisperse MRF exhibited an improved response time in terms of the particle motion and microstructure formation. In addition, the effects of the Reynolds (Re) and Hartmann (Ha) numbers on the fluid-particle interaction and flow velocity were illustrated.

2.
Mol Biotechnol ; 61(1): 20-31, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30448907

RESUMO

AP2/ERF transcription factors (TFs) represent valuable targets for the genetic manipulation of crop plants, as they participate in the control of metabolism, growth and development, as well as in the plants' response to environmental stimuli. Here, an ERF TF encoded by the chrysanthemum (Chrysanthemum morifolium) genome, designated CmERF110, was cloned and functionally characterized. The predicted CmERF110 polypeptide included a conserved DNA-binding AP2/ERF domain. A transient expression experiment revealed that the protein was deposited in the nucleus, and a transactivation experiment in yeast suggested that it had no transcriptional activity. The gene was transcribed in the chrysanthemum root, stem and leaf, with its transcript level following a circadian rhythm under both long and short days. The effect of constitutively expressing the gene in Arabidopsis thaliana was to accelerate flowering. Transcriptional profiling implied that its effect on floral initiation operated through the photoperiod pathway.


Assuntos
Arabidopsis/metabolismo , Chrysanthemum/genética , Flores/fisiologia , Regulação da Expressão Gênica de Plantas/genética , Proteínas de Plantas/metabolismo , Fatores de Transcrição/metabolismo , Arabidopsis/genética , Arabidopsis/fisiologia , Flores/genética , Filogenia , Proteínas de Plantas/análise , Proteínas de Plantas/química , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas/genética , Plantas Geneticamente Modificadas/metabolismo , Plantas Geneticamente Modificadas/fisiologia , Fatores de Transcrição/análise , Fatores de Transcrição/química , Fatores de Transcrição/genética
3.
Nanomaterials (Basel) ; 8(9)2018 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-30208649

RESUMO

The magnetorheology and dispersion stability of bidisperse magnetic particles (BMP)-based magnetorheological (MR) fluids were improved by applying a novel functional coating composed of gelatin and graphite oxide (GO) to the surfaces of the micron-sized carbonyl iron (CI) and nanoparticles Fe3O4. Gelatin acted as a grafting agent to reduce the aggregation and sedimentation of CI particles and prevent nanoparticles Fe3O4 from oxidation. In addition, a dense GO network on the surface of gelatin-coated BMP was synthesized by self-assembly to possess a better MR performance and redispersibility. The rheological properties of MR fluids containing dual-coated BMP were measured by a rotational rheometer under the presence of magnetic field and their dispersion stability was examined through sedimentation tests. The results showed that CI@Fe3O4@Gelatin@GO (CI@Fe3O4@G@GO) particles possessed enhanced MR properties and dispersion stability. In addition, the nanoparticle-enhancing effects on the dispersion stability of BMP-based MR fluids were investigated using Monte Carlo simulations.

4.
Materials (Basel) ; 11(2)2018 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-29425158

RESUMO

In this paper, a modified Fourier series method is presented for the free vibration of moderately thick orthotropic functionally graded plates with general boundary restraints based on the first-order shear deformation theory. Regardless of boundary restraints, displacements and rotations of each plate are described as an improved form of double Fourier cosine series and several closed-form auxiliary functions to eliminate all the boundary discontinuities and jumps. Exact solutions are obtained by the energy functions of the plates based on Rayleigh-Ritz method. The convergence and reliability of the current method and the corresponding theoretical formulations are verified by comparing the present results with those available in the literature, and numerous new results for orthotropic functionally graded (OFG) plates with general boundary restraints are presented. In addition, the effects of gradient index, volume fraction and geometric parameters on frequencies with general boundary restraints are illustrated.

5.
Molecules ; 21(4): 526, 2016 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-27110753

RESUMO

Sustained monoculture often leads to a decline in soil quality, in particular to the build-up of pathogen populations, a problem that is conventionally addressed by the use of either fungicide and/or soil fumigation. This practice is no longer considered to be either environmentally sustainable or safe. While the application of organic fertilizer is seen as a means of combating declining soil fertility, it has also been suggested as providing some control over certain soil-borne plant pathogens. Here, a greenhouse comparison was made of the Fusarium wilt control efficacy of various treatments given to a soil in which chrysanthemum had been produced continuously for many years. The treatments comprised the fungicide carbendazim (MBC), the soil fumigant dazomet (DAZ), the incorporation of a Paenibacillus polymyxa SQR21 (P. polymyxa SQR21, fungal antagonist) enhanced bio-organic fertilizer (BOF), and applications of BOF combined with either MBC or DAZ. Data suggest that all the treatments evaluated show good control over Fusarium wilt. The MBC and DAZ treatments were effective in suppressing the disease, but led to significant decrease in urease activity and no enhancement of catalase activity in the rhizosphere soils. BOF including treatments showed significant enhancement in soil enzyme activities and microbial communities compared to the MBC and DAZ, evidenced by differences in bacterial/fungi (B/F) ratios, Shannon-Wiener indexes and urease, catalase and sucrase activities in the rhizosphere soil of chrysanthemum. Of all the treatments evaluated, DAZ/BOF application not only greatly suppressed Fusarium wilt and enhanced soil enzyme activities and microbial communities but also promoted the quality of chrysanthemum obviously. Our findings suggest that combined BOF with DAZ could more effectively control Fusarium wilt disease of chrysanthemum.


Assuntos
Benzimidazóis/farmacologia , Carbamatos/farmacologia , Chrysanthemum/microbiologia , Fertilizantes/microbiologia , Fusarium/efeitos dos fármacos , Paenibacillus/crescimento & desenvolvimento , Doenças das Plantas/prevenção & controle , Tiadiazinas/farmacologia , Chrysanthemum/enzimologia , Fumigação/métodos , Fungicidas Industriais/farmacologia , Efeito Estufa , Doenças das Plantas/microbiologia , Raízes de Plantas/enzimologia , Rizosfera , Solo/química , Microbiologia do Solo
6.
ACS Nano ; 10(1): 1025-32, 2016 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-26651132

RESUMO

Multiferroic magnetoelectric (ME) composites exhibit sizable ME coupling at room temperature, promising applications in a wide range of novel devices. For high density integrated devices, it is indispensable to achieve a well-ordered nanostructured array with reasonable ME coupling. For this purpose, we explored the well-ordered array of isolated epitaxial BiFeO3/CoFe2O4/SrRuO3 heterostructured nanodots fabricated by nanoporous anodic alumina (AAO) template method. The arrayed heterostructured nanodots demonstrate well-established epitaxial structures and coexistence of piezoelectric and ferromagnetic properties, as revealed by transmission electron microscopy (TEM) and peizoeresponse/magnetic force microscopy (PFM/MFM). It was found that the heterostructured nanodots yield apparent ME coupling, likely due to the effective transfer of interface couplings along with the substantial release of substrate clamping. A noticeable change in piezoelectric response of the nanodots can be triggered by magnetic field, indicating a substantial enhancement of ME coupling. Moreover, an electric field induced magnetization switching in these nanodots can be observed, showing a large reverse ME effect. These results offer good opportunities of the nanodots for applications in high-density ME devices, e.g., high density recording (>100 Gbit/in.(2)) or logic devices.

7.
Ying Yong Sheng Tai Xue Bao ; 26(4): 1231-6, 2015 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-26259468

RESUMO

Abstract: Fusarium wilt is a soil borne disease caused by plant continuous cropping in monoculture Chrysanthemum morifolium 'Youxiang' monoculture not only declines plant quality and yield but also decreases soil enzymes and soil microbial diversity over successive cultivation. In this article, the effects of fungicide (Carbendazim MBC), antifungal enhanced bio-organic fertilizer (BOF), and their combined application on the quality and soil enzymes activities of Chrysanthemum morifolium 'Youxiang' in continuous cropping systems were investigated. The results showed that both bioorganic fertilizer (BOF) and fungicide (MBC) single application could effectively prevent the occurrence of Fusarium wilt disease of cut chrysanthemum. Bio-organic fertilizer application was more effective on root activity, soil enzymes activities and quality (shoot height, stem diameter, leaf SPAD value, ray floret number, shoot fresh mass) improvement of cut chrysanthemum, while fungicide single application was responsible for soil enzymatic activities suppression to some extent. The combined application treatment (MBC+BOF) showed the best effects on quality improvement and soil enzyme activities promotion.


Assuntos
Agricultura/métodos , Chrysanthemum/crescimento & desenvolvimento , Fertilizantes , Fungicidas Industriais , Microbiologia do Solo , Solo/química , Chrysanthemum/microbiologia , Enzimas/química , Fusarium , Folhas de Planta , Raízes de Plantas , Caules de Planta
8.
Nat Commun ; 6: 6680, 2015 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-25813084

RESUMO

Magnetoelectric composite thin films hold substantial promise for applications in novel multifunctional devices. However, there are presently shortcomings for both the extensively studied bilayer epitaxial (2-2) and vertically architectured nanocomposite (1-3) film systems, restricting their applications. Here we design a novel growth strategy to fabricate an architectured nanocomposite heterostructure with magnetic quasiparticles (0) embedded in a ferroelectric film matrix (3) by alternately growing (2-2) and (1-3) layers within the film. The new heteroepitaxial films not only overcome the clamping effect from substrate, but also significantly suppress the leakage current paths through the ferromagnetic phase. We demonstrate, by focusing on switching characteristics of the piezoresponse, that the heterostructure shows magnetic field dependence of piezoelectricity due to the improved coupling enabled by good connectivity amongst the piezoelectric and magnetostrictive phases. This new architectured magnetoelectric heterostructures may open a new avenue for applications of magnetoelectric films in micro-devices.

9.
Sci Rep ; 5: 9229, 2015 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-25784511

RESUMO

Dynamic oxygen vacancies play a significant role in memristive switching materials and memristors can be realized via well controlled doping. Based on this idea we deposite Nb2O5-NaNbO3 nanocomposite thin films on SrRuO3-buffered LaAlO3 substrates. Through the spontaneous phase separation and self-assembly growth, two phases form clear vertical heteroepitaxial nanostructures. The interfaces between niobium oxide and sodium niobate full of ion vacancies form the conductive channels. Alternative I-V behavior attributed to dynamic ion migration reveals the memristive switching mechanism under the external bias. We believe that this phenomenon has a great potential in future device applications.

10.
Schizophr Bull ; 41(3): 728-35, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25429046

RESUMO

BACKGROUND: Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems. METHODS: This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in an independent GWAS data including 1802 SZ cases and 1447 controls; (2) profile genome-wide miRNA expression in blood collected from 15 early-onset SZ (EOS) cases and 15 healthy controls; and (3) construct a miRNA-messenger RNA (mRNA) regulatory network using our previous genome-wide mRNA expression data generated from a separate sample of 18 EOS cases and 12 healthy controls. RESULTS: Our findings indicate that: (1) In genes associated with the control of miRNAs, there are approximately 50% more RVs in SZ cases than in controls (P ≤ 2.62E-10); (2) The observed lower miRNA activity in EOS patients compared with the healthy controls suggests that miRNAs are abnormally downregulated; (3) There exists a predicted regulatory network among some downregulated miRNAs and some upregulated mRNAs. CONCLUSIONS: Collectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ.


Assuntos
Regulação da Expressão Gênica/genética , MicroRNAs/genética , Polimorfismo de Nucleotídeo Único/genética , Esquizofrenia/genética , Adolescente , Idade de Início , Criança , Feminino , Estudo de Associação Genômica Ampla , Humanos , Masculino
12.
Nat Commun ; 5: 5162, 2014 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-25330787

RESUMO

Two-dimensional atomic crystals are extensively studied in recent years due to their exciting physics and device applications. However, a molecular counterpart, with scalable processability and competitive device performance, is still challenging. Here, we demonstrate that high-quality few-layer dioctylbenzothienobenzothiophene molecular crystals can be grown on graphene or boron nitride substrate via van der Waals epitaxy, with precisely controlled thickness down to monolayer, large-area single crystal, low process temperature and patterning capability. The crystalline layers are atomically smooth and effectively decoupled from the substrate due to weak van der Waals interactions, affording a pristine interface for high-performance organic transistors. As a result, monolayer dioctylbenzothienobenzothiophene molecular crystal field-effect transistors on boron nitride show record-high carrier mobility up to 10 cm(2) V(-1) s(-1) and aggressively scaled saturation voltage ~1 V. Our work unveils an exciting new class of two-dimensional molecular materials for electronic and optoelectronic applications.

13.
PLoS One ; 7(11): e48961, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23155434

RESUMO

BACKGROUND: The cue-related go/no-go switching task provides an experimental approach to study individual's flexibility in changing situations. Because Internet addiction disorder (IAD) belongs to the compulsive-impulsive spectrum of disorders, it should present cognitive bias and executive functioning deficit characteristics of some of these types of disorders. Until now, no studies have been reported on cognitive bias and executive function involving mental flexibility and response inhibition in IAD. METHODOLOGY/PRINCIPAL FINDINGS: A total of 46 subjects who met the criteria of the modified Young's Diagnostic Questionnaire for Internet addiction (YDQ) were recruited as an Internet game addiction (IGA) group, along with 46 healthy control individuals. All participants performed the Internet game-shifting task. Using hit rate, RT, d' and C as the dependent measures, a three-way ANOVA (group × target × condition) was performed. For hit rate, a significant effect of group, type of target and condition were found. The group-target interaction effect was significant. For RT, significant effects were revealed for group and type of target. The group-target interaction effect was significant. Comparisons of the means revealed that the slowing down of IGA relative to NIA was more pronounced when the target stimuli were neutral as opposed to Internet game-related pictures. In addition, the group-condition interaction effect was significant. For d', significant effects of group, type of target and condition were found. The group-target interaction effect was significant. For C, the type of target produced a significant effect. There was a positive correlation between the length of the addiction (number of years) and the severity of the cognitive bias. CONCLUSIONS: IGA present cognitive biases towards information related to Internet gaming. These biases, as well as poor executive functioning skills (lower mental flexibility and response inhibition), might be responsible for Internet game addiction. The assessment of cognitive biases in IGA might provide a methodology for evaluation of therapeutic effects.


Assuntos
Atenção , Comportamento Aditivo/psicologia , Cognição , Função Executiva , Jogos de Vídeo/psicologia , Adolescente , Adulto , Comportamento Aditivo/diagnóstico , Feminino , Humanos , Internet , Masculino , Testes Neuropsicológicos , Tempo de Reação , Inquéritos e Questionários
14.
Behav Brain Funct ; 6: 49, 2010 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-20738857

RESUMO

BACKGROUND: Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD. METHODS: We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according to genotypic variation were investigated by logistic regression analysis. RESULTS: There were no significant differences between MDD patients with suicide and controls in genotypic (AG and GG) frequencies for rs7305115 SNP, but the distribution of AA genotype differed significantly (14.4% vs. 29.3%, p < 0.001). The G-allele frequency was significantly higher in cases than control group (58.1% vs.45.6%, p < 0.001), but the A-allele carrier indicated a decreased trend in MDD with suicide behaviors than control group (41.9% vs.54.4%, p < 0.001). The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients. CONCLUSIONS: The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts.


Assuntos
Transtorno Depressivo Maior/genética , Tentativa de Suicídio/psicologia , Triptofano Hidroxilase/genética , Adolescente , Adulto , Idoso , Alelos , Transtorno Depressivo Maior/complicações , Emoções , Saúde da Família , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Acontecimentos que Mudam a Vida , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Fatores de Risco
15.
Psychiatry Res ; 176(1): 1-7, 2010 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-20067853

RESUMO

The aim of this study is to profile the peripheral biomarkers (tyrosine hydroxylase, TH; interleukin-1beta, IL-1beta; and tumor necrosis factor-alpha, TNF-alpha) for schizophrenia and explore their relations with clinical symptoms. Thirty-nine patients with schizophrenia were evaluated using the Positive and Negative Syndrome Scale (PANSS), and 25 siblings and 30 normal healthy subjects were used as controls. The mRNA expression levels of TH, IL-1beta and TNF-alpha in peripheral blood mononuclear cells, as determined with semi-quantitative reverse transcription-polymerase chain reaction, were all significantly increased in both patients (3-fold) and siblings (2-fold) as compared with normal control. Both IL-1beta and TNF-alpha were significantly correlated with scores on the general psychopathology subscale of the PANSS. A significant positive correlation between IL-1beta and TH expression was found in both sibling and normal controls, but not in patients, while a positive correlation between IL-1beta and TNF-alpha was significant in all the groups. These results suggest that TH, IL-1beta and TNF-alpha are overexpressed in the peripheral blood mononuclear cells of schizophrenia patients, perhaps due to the hereditary factors. IL-1beta and TNF-alpha may influence the symptoms of schizophrenia in the cognition dysfunction and anxiety/depression domains of the PANSS.


Assuntos
Regulação da Expressão Gênica/fisiologia , Interleucina-1beta/metabolismo , Leucócitos Mononucleares/metabolismo , Esquizofrenia/patologia , Fator de Necrose Tumoral alfa/metabolismo , Tirosina 3-Mono-Oxigenase/metabolismo , Adulto , Feminino , Humanos , Interleucina-1beta/genética , Leucócitos Mononucleares/imunologia , Masculino , Escalas de Graduação Psiquiátrica , RNA Mensageiro/metabolismo , Esquizofrenia/imunologia , Esquizofrenia/fisiopatologia , Estatística como Assunto , Estatísticas não Paramétricas , Fator de Necrose Tumoral alfa/genética , Tirosina 3-Mono-Oxigenase/genética , Adulto Jovem
16.
Acta Neuropsychiatr ; 22(5): 228-36, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26952833

RESUMO

UNLABELLED: Zhou Z-H, Yuan G-Z, Yao J-J, Li C, Cheng Z-H. An event-related potential investigation of deficient inhibitory control in individuals with pathological Internet use. OBJECTIVE: The purpose of this study was to investigate deficient inhibitory control in individuals with pathological Internet use (PIU) using a visual go/no-go task by event-related potentials (ERPs). METHODS: Subjects were 26 individuals with PIU and 26 controls. Barratt Impulsiveness Scale-11 (BIS-11) was used for measures of impulsivity. A go/no-go task involved eight different two-digit numerical stimuli. The response window was 1000 ms and the inter-trial-interval (ITI) was 1500 ms. Electroencephalography (EEG) was recorded when participants performed the task. Brain electrical source analysis (BESA) 5.2.0 was used to perform data analysis and the no-go N2 amplitude was analysed for investigation of inhibitory control. RESULTS: BIS-11 total scores, attentional key and motor key scores in PIU group were higher than that of the control group. In the go/no-go task, false alarm rate of PIU group was higher, and hit rate was lower than that of the control group. A repeated measure ANOVA revealed a significant group, frontal electrode sites and group × frontal electrode sites main effect for N2 amplitudes of no-go conditions (for group: F = 3953, df = 1, p = 0.000; for frontal electrode sites: F = 541, df = 9, p = 0.000; for group × frontal electrode sites: F = 306, df = 9, p = 0.000), and a significant group, central electrode sites and group × central electrode sites main effect for N2 amplitudes of no-go conditions (for group: F = 9074, df = 1, p = 0.000; for central electrode sites: F = 163, df = 2, p = 0.000; for group × central electrode sites: F = 73, df = 2, p = 0.000). N2 amplitudes of no-go conditions were lower than those at control group. CONCLUSIONS: Individuals with PIU were more impulsive than controls and shared neuropsychological and ERPs characteristics of compulsive-impulsive spectrum disorder, which supports that PIU is an impulse disorder or at least related to impulse control disorder.

17.
Appl Phys Lett ; 95(5): 52905, 2009 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-19730707

RESUMO

We report the finding of a monoclinic M(B) phase in Pb(Zn(13)Nb(23))O(3)-4.5%PbTiO(3) single crystals. High precision x-ray diffraction investigations of [110] field cooled crystals have shown a transformation sequence of cubic(C)-->tetragonal(T)-->orthorhombic(O)-->monoclinic(M(B)), which is different from that previously reported [A.-E. Renault et al., J. Appl. Phys. 97, 044105 (2005)]. Beginning in the zero-field-cooled condition at 383 K, a rhombohedral (R)-->M(B)-->O sequence was observed with increasing field. Coexisting M(B) and O phases were then found upon removal of field, which fully transformed to M(B) on cooling to room temperature.

18.
ACS Nano ; 3(10): 3045-50, 2009 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-19754131

RESUMO

A novel approach to control the grain size of oxide thin film materials has been investigated. Perovskite BaTiO(3) shows interesting grain structures when deposited on gold predeposited, (111)-oriented, single-crystal SrTiO(3) substrates. Solid oxide films grow epitaxially on patterned seed layers and show variations in grain size relative to the films deposited on SrTiO(3) directly.

19.
Acta Neuropsychiatr ; 21(1): 26-33, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25384526

RESUMO

OBJECTIVE: The purpose of this study was to investigate whether the effects of quetiapine on abnormalities of early auditory processing in patients with schizophrenia were reflected by mismatch negativity (MMN). METHODS: Subjects were 23 patients with schizophrenia and 23 controls. Psychopathology was rated in patients with the Positive and Negative Syndrome Scale (PANSS) at baseline and after 4-week and after 8-week treatments with quetiapine. Auditory stimuli for event-related potentials consisted of 100 ms/1000 Hz standards, intermixed with 100 ms/1500 Hz frequency deviants and 250 ms/ 1000 Hz duration deviants. A stimulus onset asynchrony of each was 300 ms. Electroencephalograph was recorded at Fz. BESA 5.1.8 was used to perform data analysis. MMN waveforms were obtained by subtracting waveforms elicited by standards from those elicited by frequency- or duration-deviant stimuli. RESULTS: Quetiapine decreased all PANSS scores. Patients showed smaller mean amplitudes of frequency and duration MMN at baseline than did controls. A repeated measure analysis of variance with sessions (i.e. baseline and 4- and 8-week treatments) and MMN type (frequency versus duration) as within-subject factors revealed no significant MMN type or MMN type × session main effect for MMN amplitudes (for MMN type: F = 0.704, df = 1, p = 0.403; for MMN type × session: F = 0.299, df = 2, p = 0.796). Session main effect was significant (F = 3.576, df = 2, p = 0.031). Least square difference tests showed significant differences between MMN amplitudes at 8 weeks and those at both baseline (p = 0.025) and 4 weeks (p = 0.020). MMN amplitudes at 8 weeks were higher than those at baseline. CONCLUSIONS: Quetiapine improved the amplitudes of MMN after the 8-week treatment. MMN offers objective evidence that treatment with the quetiapine may ameliorate preattentive deficits in schizophrenia.

20.
Zhonghua Liu Xing Bing Xue Za Zhi ; 28(2): 131-5, 2007 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-17649681

RESUMO

OBJECTIVE: To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism(SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression. METHODS: Paired case-control study on 215 suicide attempters with major depression (92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age (no more than 3 years) and from the same district. RESULTS: There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 (95% CI: 0.22-0.99), 7.68 (95% CI: 5.79-13.74), 6.64 (95% CI: 2.48-11.04), 2.98 (95% CI: 1.17-5.04) respectively. There was no first level interaction between any of the two risk factors. CONCLUSION: Results from the study supported the idea that hopelessness, negative life-events and family history of suicide were risk factors of attempted suicide in major deprbssion while TPH2 gene rs7305115 A/A might be the protective factor.


Assuntos
Transtorno Depressivo Maior/psicologia , Tentativa de Suicídio/psicologia , Tentativa de Suicídio/estatística & dados numéricos , Triptofano Hidroxilase/genética , Estudos de Casos e Controles , China/epidemiologia , Transtorno Depressivo Maior/genética , Humanos , Razão de Chances , Polimorfismo de Nucleotídeo Único , Fatores de Risco
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