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2.
Front Cardiovasc Med ; 8: 740526, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34692792

RESUMO

Lysosomal-associated protein transmembrane 5 (LAPTM5) is mainly expressed in immune cells and has been reported to regulate inflammation, apoptosis and autophagy. Although LAPTM5 is expressed in the heart, whether LAPTM5 plays a role in regulating cardiac function remains unknown. Here, we show that the expression of LAPTM5 is dramatically decreased in murine hypertrophic hearts and isolated hypertrophic cardiomyocytes. In this study, we investigated the role of LAPTM5 in pathological cardiac hypertrophy and its possible mechanism. Our results show that LAPTM5 gene deletion significantly exacerbates cardiac remodeling, which can be demonstrated by reduced myocardial hypertrophy, fibrosis, ventricular dilation and preserved ejection function, whereas the opposite phenotype was observed in LAPTM5 overexpression mice. In line with the in vivo results, knockdown of LAPTM5 exaggerated angiotensin II-induced cardiomyocyte hypertrophy in neonatal rat ventricular myocytes, whereas overexpression of LAPTM5 protected against angiotensin II-induced cardiomyocyte hypertrophy in vitro. Mechanistically, LAPTM5 directly bound to Rac1 and further inhibited MEK-ERK1/2 signaling, which ultimately regulated the development of cardiac hypertrophy. In addition, the antihypertrophic effect of LAPTM5 was largely blocked by constitutively active mutant Rac1 (G12V). In conclusion, our results suggest that LAPTM5 is involved in pathological cardiac hypertrophy and that targeting LAPTM5 has great therapeutic potential in the treatment of pathological cardiac hypertrophy.

3.
Comput Methods Programs Biomed ; 212: 106468, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34715513

RESUMO

BACKGROUND: With outbreaks of COVID-19 around the world, lockdown restrictions are routinely imposed to limit the spread of the virus. During periods of lockdown, social media has become the main channel for citizens to exchange information with others. Public emotions are being generated and shared rapidly online with citizens using internet platforms to reduce anxiety and stress, and stay connected while isolated. OBJECTIVES: This study aims to explore the regularity of emotional evolution by examining public emotions expressed in online discussions about the Wuhan lockdown event in January 2020. METHODS: Data related to the Wuhan lockdown was collected from Sina Weibo by web crawler. In this study, the Ortony, Clore, and Collins (OCC) model, Word2Vec, and Bi-directional Long Short-Term Memory model were employed to determine emotional types, train vectorization of words, and identify each text emotion for the training set. Latent Dirichlet Allocation models were also employed to mine the various topic categories, while topic emotional evolution was visualized. RESULTS: Seven types of emotions and four phases were categorized to describe emotional evolution on the Wuhan lockdown event. The study found that negative emotions such as blame and fear dominated in the early days, and public attitudes towards the lockdown gradually alleviated and reached a balance as the situation improved. Emotional expression about Wuhan lockdown event were significantly related to users' gender, location, and whether or not their account was verified. There were statistically significant correlations between different emotions within the subtle emotional categories. In addition, the evolution of emotions presented a different path due to different topics. CONCLUSIONS: Multiple emotional categories were determined in our study, providing a detailed and explainable emotion analysis to explored emotional appeal of citizen. The public emotions were gradually easing related to the Wuhan lockdown event, there yet exists regional discrimination and post-traumatic stress disorder in this process, which would lead us to pay continuous attention to citizens lives and psychological status post-pandemic. In addition, this study provided an appropriate method and reference case for the government's public opinion control and emotional appeasement.


Assuntos
COVID-19 , Mídias Sociais , Controle de Doenças Transmissíveis , Emoções , Humanos , Pandemias , SARS-CoV-2
4.
Bioengineered ; 12(1): 8724-8737, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34698001

RESUMO

Increasing evidence demonstrated long non-coding RNAs (lncRNAs) play important roles in the occurrence and development of oral squamous cell carcinoma (OSCC). This study aimed to explore the role and molecular mechanism of lncRNA HOXA-AS3 in the progression of OSCC. Here, we found that the expression of lncRNA HOXA-AS3 was upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Inhibition of HOXA-AS3 significantly inhibited the proliferation and colony formation of OSCC cells. Further, the luciferase reporter assay showed that HOXA-AS3 was directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and miR-218-5p could inhibit the expression of collagen type I alpha1 (COL1A1) and lysophosphatidylcholine acyltransferase 1 (LPCAT1). In addition, silencing miR-218-5p reversed the inhibitory effect of HOXA-AS3 knockdown on the proliferative potential of OSCC cells. In summary, our study illustrated that HOXA-AS3 promoted cancer cell proliferation in OSCC, possibly by sponging miR-218-5p for the first time, which provides a new target or a potential diagnostic biomarker for OSCC.

5.
Hepatology ; 2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34591986

RESUMO

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance (IR), obesity and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved. Ovarian tumor (OTU) domain, ubiquitin aldehyde binding 1 (OTUB1), the founding member of deubiquitinases (DUBs), regulates many metabolism-associated signaling pathways. However, the role of OTUB1 in NASH is unclarified. METHODS & RESULTS: We demonstrated that mice with Otub1 deficiency exhibited aggravated high-fat diet (HFD)- and high-fat high-cholesterol (HFHC) diet-induced hyperinsulinemia and liver steatosis. Notably, hepatocyte-specific overexpression of Otub1 markedly alleviated HFHC diet-induced hepatic steatosis, inflammatory responses and liver fibrosis. Mechanistically, we identified apoptosis signal-regulating kinase 1 (ASK1) as a key candidate target of OTUB1 through RNA-seq analysis and immunoblot analysis. Through immunoprecipitation-mass spectrometry (IP-MS) analysis, we further found that OTUB1 directly bound to tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppressed its lysine 63 (K63)-linked polyubiquitination, thus inhibiting the activation of ASK1 and its downstream pathway. CONCLUSION: OTUB1 is a key suppressor of NASH that inhibits polyubiquitinations of TRAF6 and attenuated TRAF6-mediated ASK1 activation. Targeting the OTUB1-TRAF6-ASK1 axis may be a promising novel therapeutic strategy for NASH.

6.
Front Oncol ; 11: 732704, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34527594

RESUMO

Background: The effectiveness of conventional MRI (cMRI)-based radiomics in differentiating glioblastoma (GBM) from solitary brain metastases (SBM) is not satisfactory enough. Therefore, we aimed to develop an integrated radiomics model to improve the performance of differentiating GBM from SBM. Methods: One hundred patients with solitary brain tumors (50 with GBM, 50 with SBM) were retrospectively enrolled and randomly assigned to the training set (n = 80) or validation set (n = 20). A total of 4,424 radiomic features were obtained from contrast-enhanced T1-weighted imaging (CE-T1WI) with the contrast-enhancing and peri-enhancing edema region, T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI)-derived apparent diffusion coefficient (ADC), and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images. The partial least squares (PLS) regression with fivefold cross-validation is used to analyze the correlation between different radiomic features and different modalities. The cross-validity analysis was performed to judge whether a new principal component or a new feature dimension can significantly improve the final prediction effect. The principal components with effective interpretation in all radiomic features were projected to a low-dimensional space (2D in this study). The effective features of the new projection mapping were then sent to the random forest classifier to predict the results. The performance of differentiating GBM from SBM was compared between the integrated radiomics model and other radiomics models or nonradiomics methods using the area under the receiver operating characteristics curve (AUC). Results: Through the cross-validity analysis of partial least squares, hundreds of radiomic features were projected into a new two-dimensional space to complete the construction of radiomics model. Compared with the combined radiomics model using DWI + 18F-FDG PET (AUC = 0.93, p = 0.014), cMRI + DWI (AUC = 0.89, p = 0.011), cMRI + 8F-FDG PET (AUC = 0.91, p = 0.015), and single radiomics model using cMRI (AUC = 0.85, p = 0.018), DWI (AUC = 0.84, p = 0.017), and 18F-FDG PET (AUC = 0.85, p = 0.421), the integrated radiomics model (AUC = 0.98) showed more efficient diagnostic performance. The integrated radiomics model (AUC = 0.98) also showed significantly better performance than any single ADC, SUV, or TBR parameter (AUC = 0.57-0.71, p < 0.05). The integrated radiomics model showed better performance in the training (AUC = 0.98) and validation (AUC = 0.93) sets than any other models and methods, demonstrating robustness. Conclusions: We developed an integrated radiomics model incorporating DWI and 18F-FDG PET, which improved the performance of differentiating GBM from SBM greatly.

7.
Chem Commun (Camb) ; 57(75): 9574-9577, 2021 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-34546234

RESUMO

Novel thin UZM-5 zeolite membranes with pure UFI phase were successfully fabricated using a charge density mismatch-assisted tertiary growth approach. Taking full advantage of the suitable Si/Al ratio and pore size, the obtained novel zeolite membranes revealed an outstanding acid-resistant capacity and provided great potential for acetic acid pervaporation dehydration applications.


Assuntos
Membranas Artificiais , Zeolitas/síntese química , Desidratação , Concentração de Íons de Hidrogênio , Tamanho da Partícula , Zeolitas/química
8.
ISA Trans ; 2021 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-34446283

RESUMO

Mathematical morphology spectrum entropy is a signal feature extraction method based on information entropy and mathematical morphology. The scale of structure element is a critical parameter, whose value determines the accuracy of feature extraction. Existing scale selection methods depend on experiment parameters or external indicators including noise ratio, fault frequencies, etc. In many cases, existing methods obtain fix scale and they are not suitable for quantifying the performance degradation and the fault degree of bearings. There are few researches on scale selection based on the properties of mathematical morphology spectrum. In this study, a scale-adaptive mathematical morphology spectrum entropy (AMMSE) is proposed to improve the scale selection. To support the proposed method, two properties of the mathematical morphology spectrum (MMS), namely non-negativity and monotonic decreasing, are proved. It can be concluded from the two properties that the feature loss of MMS decreases with the increase of scale. Based on the conclusion, two adaptive scale selection strategies are proposed to automatically determine the scale by reducing the feature loss of MMS. AMMSE is the integration of two strategies. Compare to the existing methods, AMMSE is not constrained by the information of the experiment and the signal. The scale of AMMSE changes with the signal characteristics and is no longer fixed by experimental parameters. The parameters of AMMSE are more generalizable as well. The presented method is applied to identify fault degree on CWRU bearing data set and evaluate performance degradation on IMS bearing data set. The experiment result shows that AMMSE has better results in both experiments with the same parameters.

9.
Curr Med Sci ; 41(4): 746-756, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34403100

RESUMO

The use of an antibiotic with immunomodulatory properties could be fascinating in treating multifactorial inflammatory conditions such as ulcerative colitis (UC). We report our investigations into the immunomodulatory properties of levornidazole, the S-enantiomer of ornidazole, which displayed a tremendous therapeutic potential in UC induced by dextran sodium sulfate (DSS). Levornidazole administration to DSS-colitic mice attenuated the intestinal inflammatory process, with an efficacy better than that shown by 5-amino salicylic acid. This was evidenced by decreased disease activity index, ameliorated macroscopic and microscopic colon damages, and reduced expression of inflammatory cytokines. Additionally, levornidazole displayed anti-inflammatory activity through Caveolin-1-dependent reducing IL-1ß and IL-18 secretion by macrophages contributing to its improvement of the intestinal inflammation, as confirmed in vitro and in vivo. In conclusion, these results pointed out that the immunomodulatory effects of levornidazole played a vital role in ameliorating the intestinal inflammatory process, which would be crucial for the translation of its use into clinical settings.

10.
Small ; 17(35): e2100683, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34310042

RESUMO

Designing highly selective and cost-effective electrocatalysts toward electrochemical carbon dioxide (CO2 ) reduction is crucial for desirable transformation of greenhouse gas into fuels or high-value chemical products. Here, the authors report intermetallic Cu3 Sn that is in situ formed and seamlessly integrated on self-supported bimodal nanoporous Cu skeleton (Cu3 Sn/Cu) via a spontaneous alloying of Sn and Cu as robust electrocatalyst for selective electroreduction of CO2 to CO. By virtue of Sn atoms strengthening CO adsorption on Cu atoms, the intermetallic Cu3 Sn has an intrinsic activity of ≈10.58 µA cm-2 , more than 80-fold higher than that of monometallic Cu. By virtue of hierarchical bicontinuous nanoporous Cu architecture facilitating electron transfer and CO2 and proton mass transport and offering high specific surface areas for full use of electroactive Cu3 Sn sites, the nanoporous Cu3 Sn/Cu hybrid electrodes produce CO at a low overpotential of 0.09 V, and exhibit high partial current density of ≈15 mA cm-2 geo at overpotential of 0.59 V, along with excellent stability and selectivity of 91.5% Faradaic efficiency. The outstanding electrochemical performance make them attractive alternatives to precious Au- and Ag-based electrocatalysts for building low-cost CO2 electrolyzers to selectively produce CO.

11.
Angew Chem Int Ed Engl ; 60(35): 19047-19052, 2021 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-34288296

RESUMO

Two-dimensional covalent organic frameworks (2D COFs) are considered as potential candidates for gas separation membranes, benefiting from permanent porosity, light-weight skeletons, excellent stability and facilely-tailored functionalities. However, their pore sizes are generally larger than the kinetic diameters of common gas molecules. One great challenge is the fabrication of single-phase COF membranes to realize precise gas separations. Herein, three kinds of high-quality ß-ketoenamine-type COF nanosheets with different pore sizes were developed and aggregated to ultrathin nanosheet membranes with distinctive staggered stacking patterns. The narrowed pore sizes derived from the micro-structures and selective adsorption capacities synergistically endowed the COF membranes with intriguing CO2 -philic separation performances, among which TpPa-2 with medium pore size exhibited an optimal CO2 /H2 separation factor of 22 and a CO2 permeance of 328 gas permeation units at 298 K. This membrane performance reached the target with commercial feasibility for syngas separations.

12.
IEEE Trans Image Process ; 30: 5652-5664, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34125678

RESUMO

Image co-segmentation is an active computer vision task that aims to segment the common objects from a set of images. Recently, researchers design various learning-based algorithms to undertake the co-segmentation task. The main difficulty in this task is how to effectively transfer information between images to make conditional predictions. In this paper, we present CycleSegNet, a novel framework for the co-segmentation task. Our network design has two key components: a region correspondence module which is the basic operation for exchanging information between local image regions, and a cycle refinement module, which utilizes ConvLSTMs to progressively update image representations and exchange information in a cycle and iterative manner. Extensive experiments demonstrate that our proposed method significantly outperforms the state-of-the-art methods on four popular benchmark datasets - PASCAL VOC dataset, MSRC dataset, Internet dataset, and iCoseg dataset, by 2.6%, 7.7%, 2.2%, and 2.9%, respectively.

13.
Sci Total Environ ; 793: 148443, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34171807

RESUMO

Diffuse radiation allocated by cloud cover and aerosols can promote vegetation photosynthesis, which is known as the diffuse fertilization effect (DFE). As an important uncertain factor regulating the DFE, understanding the role of environmental conditions in the response of terrestrial ecosystems to diffuse radiation is vital for quantitative and intensive studies. By using a light use efficiency model and statistical methods with satellite data and ChinaFLUX observation data, the optimal environmental range of DFE was estimated, the indirect role of vapor pressure deficit (VPD) and air temperature (Ta) on DFE was explored, and the relative contribution of diffuse photosynthetically active radiation (PARdif) on gross primary productivity (GPP) was analyzed across Chinese ecosystems under different sky conditions. The results showed that the DFE increased with leaf area index (LAI), but distributed a unimodal curve along with VPD and Ta, both of which had an optimum range that was lower in the forest (or cropland) and higher in the grass (or desert) ecosystem. When considering the co-effect of VPD and Ta, the strongest positive effect of DFE was found at 0-5 h Pa and 20-25 °C. Based on path analysis, PARdif promoted GPP and served as the main controlling factor in forest ecosystems predominantly through a direct pathway from half-hourly to the daily scale, while Ta and VPD occupied the dominant position at single-canopy ecosystem sites. When the aerosol optical depth (AOD) increased, the relative contribution of PARdif increased in multiple-canopy ecosystems and decreased in single-canopy ecosystems; when the sky conditions changed from sunny to cloudy, the relative contribution of PARdif was higher in the forest ecosystem and increased significantly in the grass ecosystem. These findings offer a more comprehensive understanding of the environmental effects of regulating DFE on GPP across ecosystems.


Assuntos
Ecossistema , Florestas , China , Fertilização , Fotossíntese , Estações do Ano
14.
Front Vet Sci ; 8: 603919, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34179152

RESUMO

Bovine Viral Diarrhea Virus (BVDV) is the main pathogen of bovine viral diarrhea disease (BVD), which leads to enormous economic losses in the cattle industry. A sensitive and specific detection for BVDV is advantageous to the control of BVDV. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have been used for detecting virus RNA. In this study, the expression and purification of LwCas13a protein was optimized and the RNase activity of LwCas13a in vitro was verified. CRISPR-LwCas13a system could detect BVDV virus and BVDV RNA with high specificity and simplicity. The detection limit of the LwCas13a system was 103 pM, and there were no cross-reactions with HEK293T and MDBK. In summary, a sensitive, specific, and simple nucleic acid detection method based on CRISPR-Cas13a was developed for BVDV. This method provides a new detection strategy for early diagnosis of BVDV.

15.
Biomed Chromatogr ; 35(10): e5173, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33982286

RESUMO

Hydroxysafflor yellow A (HSYA), a major active water-soluble component in Carthamus tinctorius L., is considered a potential antioxidant with protective effects against myocardial injury. However, its pharmacokinetic characteristics in normal and diabetic cardiomyopathy (DCM) mice remain unknown. This study was designed to investigate the differences in the pharmacokinetics of HSYA between normal and streptozotocin-induced DCM mice. HSYA in the mouse plasma was quantified using LC-MS/MS. Compared with the normal group, the DCM group showed a significantly higher area under the curve (AUC(0-t) , AUC(0-∞) ) value and peak plasma concentration, suggesting a higher uptake of HSYA in the DCM mice, and a significantly lower plasma clearance and apparent volume of distribution, suggesting slower elimination of HSYA in the DCM mice. The levels of serum superoxide dismutase and glutathione peroxidase were significantly higher, and malondialdehyde content was significantly lower in DCM mice than in normal mice, indicating the antioxidative stress effect of HSYA. Furthermore, the correlation analysis revealed that the serum HSYA content in the DCM mice significantly positively correlated with antioxidant enzyme levels. These results showed that the pharmacokinetics of HSYA changed significantly in the DCM mice, and this may improve the antioxidative stress effect of the drug.


Assuntos
Antioxidantes , Chalcona/análogos & derivados , Cardiomiopatias Diabéticas/metabolismo , Quinonas , Animais , Antioxidantes/análise , Antioxidantes/química , Antioxidantes/farmacocinética , Carthamus tinctorius , Chalcona/sangue , Chalcona/química , Chalcona/farmacocinética , Cromatografia Líquida , Coração/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Miocárdio/patologia , Quinonas/sangue , Quinonas/química , Quinonas/farmacocinética , Espectrometria de Massas em Tandem
16.
Signal Transduct Target Ther ; 6(1): 194, 2021 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-34001849

RESUMO

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is a humanized anti-CD147 IgG2 monoclonal antibody, which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019 (COVID-19) patients. Here, we conducted a randomized, double-blinded, placebo-controlled phase 1 trial to evaluate the safety, tolerability, and pharmacokinetics of meplazumab in healthy subjects, and an open-labeled, concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients. In phase 1 study, 59 subjects were enrolled and assigned to eight cohorts, and no serious treatment-emergent adverse event (TEAE) or TEAE grade ≥3 was observed. The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics. No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort. The biodistribution study indicated that meplazumab reached lung tissue and maintained >14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32. In the exploratory phase 2 study, 17 COVID-19 patients were enrolled, and 11 hospitalized patients were involved as concurrent control. The meplazumab treatment significantly improved the discharged (P = 0.005) and case severity (P = 0.021), and reduced the time to virus negative (P = 0.045) in comparison to the control group. These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.


Assuntos
Anticorpos Monoclonais Humanizados , COVID-19/tratamento farmacológico , COVID-19/metabolismo , Pulmão/metabolismo , SARS-CoV-2/metabolismo , Adolescente , Adulto , Anticorpos Monoclonais Humanizados/administração & dosagem , Anticorpos Monoclonais Humanizados/efeitos adversos , Anticorpos Monoclonais Humanizados/farmacocinética , COVID-19/patologia , Método Duplo-Cego , Feminino , Humanos , Pulmão/patologia , Pulmão/virologia , Masculino , Pessoa de Meia-Idade
17.
Appl Res Qual Life ; : 1-22, 2021 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-33968280

RESUMO

In response to the COVID-19 pandemic, restrictions on economic activities have resulted in a sharp rise of unemployment. The purpose of this research is to explore mental disorders associated with COVID-19 related unemployment using a large, nationally representative dataset, the 2020 COVID-19 Household Pulse Survey. ANOVA with post hoc tests (Tukey HSD) are utilized to reveal the mean difference of mental disorders between various employment status, as well as between reasons of unemployment. Binary logit model is used to investigate the potential effect of different reasons of unemployment on mental disorders. Individuals who were not working during the pandemic due to involuntary reasons had higher probabilities of mental disorders than those who were working and those who voluntarily separated from work. Among respondents who were not working due to COVID-19 related reasons, respondents whose employer went out of business were the most likely to experience mental disorders. Household job uncertainty in the next four weeks positively contributed to mental disorders. Government should consider measures to contain the spread of virous while keeping as many people employed as possible. Government should also consider providing adequate financial and counseling assistance to individuals who are in the greatest need for such support.

18.
Sci Total Environ ; 772: 145607, 2021 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-33770859

RESUMO

The canopy layer urban heat island (CLUHI) and surface urban heat island (SUHI) refer to higher canopy layer and land surface temperatures in urban areas than in rural areas, respectively. The long-term trends of CLUHIs are poorly understood at the regional scale. In this study, 1 km resolution air temperature (Ta) data for the 2001-2018 period in the mainland of China were mapped using satellite data and station-based Ta data. Subsequently, the temporal trends of the CLUHI and SUHI intensities (CLUHII and SUHII, respectively) were investigated in 272 cities in the mainland of China. The Ta was estimated with high accuracy, with a root mean square error ranging from 0.370 °C to 0.592 °C. The CLUHII and SUHII increased significantly in over half of the cities in spring and summer, over one-third of the cities in autumn, and over one-fifth of the cities in winter. The trends of the nighttime SUHII were strongly related to the CLUHII calculated using mean and minimum Ta (correlation coefficients ranging from 0.613 to 0.770), whereas the relationships between the trends of the daytime SUHII and CLUHII were relatively weak. Human activities were the major driving forces for the increase in the CLUHII and SUHII. The difference in impervious surfaces between urban and rural areas was significantly correlated with the CLUHII and SUHII in approximately half of the cities. Meteorological factors were significantly correlated with the CLUHII and SUHII in few cities. This study highlights the trends of the significant increase in the CLUHII and SUHII in the mainland of China, which may have negative effects on humans and the environment.

19.
JMIR Med Inform ; 9(3): e27079, 2021 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-33724200

RESUMO

BACKGROUND: Wuhan, China, the epicenter of the COVID-19 pandemic, imposed citywide lockdown measures on January 23, 2020. Neighboring cities in Hubei Province followed suit with the government enforcing social distancing measures to restrict the spread of the disease throughout the province. Few studies have examined the emotional attitudes of citizens as expressed on social media toward the imposed social distancing measures and the factors that affected their emotions. OBJECTIVE: The aim of this study was twofold. First, we aimed to detect the emotional attitudes of different groups of users on Sina Weibo toward the social distancing measures imposed by the People's Government of Hubei Province. Second, the influencing factors of their emotions, as well as the impact of the imposed measures on users' emotions, was studied. METHODS: Sina Weibo, one of China's largest social media platforms, was chosen as the primary data source. The time span of selected data was from January 21, 2020, to March 24, 2020, while analysis was completed in late June 2020. Bi-directional long short-term memory (Bi-LSTM) was used to analyze users' emotions, while logistic regression analysis was employed to explore the influence of explanatory variables on users' emotions, such as age and spatial location. Further, the moderating effects of social distancing measures on the relationship between user characteristics and users' emotions were assessed by observing the interaction effects between the measures and explanatory variables. RESULTS: Based on the 63,169 comments obtained, we identified six topics of discussion-(1) delaying the resumption of work and school, (2) travel restrictions, (3) traffic restrictions, (4) extending the Lunar New Year holiday, (5) closing public spaces, and (6) community containment. There was no multicollinearity in the data during statistical analysis; the Hosmer-Lemeshow goodness-of-fit was 0.24 (χ28=10.34, P>.24). The main emotions shown by citizens were negative, including anger and fear. Users located in Hubei Province showed the highest amount of negative emotions in Mainland China. There are statistically significant differences in the distribution of emotional polarity between social distancing measures (χ220=19,084.73, P<.001), as well as emotional polarity between genders (χ24=1784.59, P<.001) and emotional polarity between spatial locations (χ24=1659.67, P<.001). Compared with other types of social distancing measures, the measures of delaying the resumption of work and school or travel restrictions mainly had a positive moderating effect on public emotion, while traffic restrictions or community containment had a negative moderating effect on public emotion. CONCLUSIONS: Findings provide a reference point for the adoption of epidemic prevention and control measures, and are considered helpful for government agencies to take timely actions to alleviate negative emotions during public health emergencies.

20.
BMC Complement Med Ther ; 21(1): 78, 2021 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-33637069

RESUMO

BACKGROUND: Oxidative stress and inflammation promote the development of diabetic cardiomyopathy (DCM). Therefore, inhibiting these processes may show beneficial effects in the treatment of patients with DCM. Taohuajing (THJ) is prepared using Persicae semen (Taoren), Polygonatum sibiricum (Huangjing), and Carthami flos (Honghua) and may have applications in the treatment of DCM. However, the protective effects of THJ have not been thoroughly assessed. Accordingly, in this study, we aimed to investigate the protective effects of THJ in a model of DCM and further clarify the potential mechanisms. METHODS: A type 2 diabetes mellitus model was generated using male C57BL/6 mice. Echocardiography and histopathology were used to evaluate cardiac function. The expression levels of cytokines were measured using enzyme-linked immunosorbent assays. Western blotting and small interfering RNA were used to evaluate the targets of THJ. RESULTS: Compared with the control group, DCM mice showed cardiac dysfunction, metabolic disorder, fibrosis, and disorganized ultrastructure, and THJ treatment significantly inhibited these changes significantly. THJ treatment also inhibited the production of reactive oxygen species (ROS) and malondialdehyde (MDA), induced the production of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), decreased the levels of pro-inflammatory cytokines, and suppressed the activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome. These protective effects were abolished by sirtinol, an inhibitor of sirtuin1 (SIRT1). CONCLUSIONS: Overall, THJ protected the heart from hyperglycemia-induced oxidative stress and inflammation in DCM mice via a mechanism involving SIRT1-mediated antioxidant proteins and suppression of the NLRP3 inflammasome.


Assuntos
Cardiomiopatias Diabéticas/tratamento farmacológico , Medicamentos de Ervas Chinesas/administração & dosagem , Sirtuína 1/metabolismo , Animais , Diabetes Mellitus Tipo 2/complicações , Cardiomiopatias Diabéticas/etiologia , Cardiomiopatias Diabéticas/genética , Cardiomiopatias Diabéticas/metabolismo , Glutationa Peroxidase/genética , Glutationa Peroxidase/metabolismo , Humanos , Masculino , Malondialdeído/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Espécies Reativas de Oxigênio/metabolismo , Transdução de Sinais/efeitos dos fármacos , Sirtuína 1/genética , Superóxido Dismutase/genética , Superóxido Dismutase/metabolismo
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