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Clin Rheumatol ; 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31797168


OBJECTIVES: To compare the performance of conventional radiography, ldCT, and MRI in the diagnosis of sacroiliitis in suspected axial spondyloarthritis (axSpA). METHODS: Patients presenting with > 3 months chronic back pain were assessed by axSpA-experienced rheumatologists and diagnosed as axSpA or not; axSpA patients were then considered nr-axSpA or AS using plain radiography. Non-axSpA patients were recruited as controls, and divided into non-inflammatory and inflammatory groups on the basis of inflammatory back pain and/or CRP/ESR elevation. Clinical variables, pelvic radiography, sacroiliac joint (SIJ) ldCT, and SIJ MRI were obtained. RESULTS: A total of 121 patients were included and had SIJ radiography and ldCT, of whom 71 additionally had an SIJ MRI. These included 23 non-inflammatory controls, 21 inflammatory controls, 32 nr-axSpA cases, and 45 AS cases. Fourteen of 32 (44%) nr-axSpA patients had positive ldCT scans, 21/24 (88%) had MRI-BMO, and 11/24 (46%) had MRI-structural lesions. ldCT had high specificity with only 1/23 (4%) non-inflammatory controls being positive. MRI-BMO had the highest sensitivity for nr-axSpA, but compared with ldCT lower specificity, with 5/15 (33%) of non-inflammatory controls being positive, and similar sensitivity for AS (20/22 (91%) vs 44/44 for ldCT). CONCLUSIONS: ldCT identifies evidence of radiographic change in a significant proportion of nr-axSpA cases and is highly specific for axSpA. MRI-BMO lesions are more sensitive than either conventional radiography or MRI-structural assessment for axSpA. The relative position of these imaging modalities in screening for axSpA needs to be reconsidered, also taking into account the costs involved.Key Points• ldCT is more sensitive for erosions or sclerosis in axSpA than plain radiography, with 44% of patients with nr-axSpA having evidence of AS-related sacroiliac joint changes on ldCT.• MRI-structural lesions are no more sensitive but are less specific for AS than ldCT.• MRI-BMO is the most sensitive test for nr-axSpA of the modalities tested but is less specific for axSpA than for ldCT.

Biochem Biophys Res Commun ; 467(1): 164-70, 2015 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-26392308


OBJECTIVE: The farnesoid-X-receptor (FXR) is a metabolic nuclear receptor superfamily member that is highly expressed in enterohepatic tissue and is also expressed in the cardiovascular system. Multiple nuclear receptors, including FXR, play a pivotal role in cardiovascular disease (CVD). Pulmonary arterial hypertension (PAH) is an untreatable cardiovascular system disease that leads to right heart failure (RHF). However, the potential physiological/pathological roles of FXR in PAH and RHF are unknown. We therefore compared FXR expression in the cardiovascular system in PAH, RHF and a control. METHODS AND RESULTS: Hemodynamic parameters and morphology were assessed in blank solution-exposed control, monocrotaline (MCT)-exposed PAH (4 weeks) and RHF (7 weeks) Sprague-Dawley rats. Real-time reverse transcription polymerase chain reaction (real-time RT-PCR), Western blot (WB), immunohistochemistry (IHC) analysis and immunofluorescence (IF) analysis were performed to assess FXR levels in the lung and heart tissues of MCT-induced PAH and RHF rats. In normal rats, low FXR levels were detected in the heart, and nearly no FXR was expressed in rat lungs. However, FXR expression was significantly elevated in PAH and RHF rat lungs but reduced in PAH and RHF rat right ventricular (RV) tissues. FXR expression was reduced only in RHF rat left ventricular (LV) tissues. CONCLUSIONS: The differential expression of FXR in MCT-induced PAH lungs and heart tissues in parallel with PAH pathophysiological processes suggests that FXR contributes to PAH.

Insuficiência Cardíaca/genética , Insuficiência Cardíaca/metabolismo , Hipertensão Pulmonar/genética , Hipertensão Pulmonar/metabolismo , Receptores Citoplasmáticos e Nucleares/genética , Receptores Citoplasmáticos e Nucleares/metabolismo , Animais , Modelos Animais de Doenças , Expressão Gênica , Insuficiência Cardíaca/induzido quimicamente , Ventrículos do Coração/metabolismo , Hipertensão Pulmonar/induzido quimicamente , Hipertrofia Ventricular Direita/induzido quimicamente , Hipertrofia Ventricular Direita/genética , Hipertrofia Ventricular Direita/metabolismo , Pulmão/metabolismo , Masculino , Monocrotalina/toxicidade , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Ratos , Ratos Sprague-Dawley , Remodelação Vascular , Remodelação Ventricular
Fa Yi Xue Za Zhi ; 25(6): 447-50, 2009 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-20225624


Sarcophagus beetles, which can not be replaced by Diptera, play a pivotal role not only in estimating PMI of dry human skeletal remains in the later stages decomposition of carcasses, but also the corruption, destruction, decomposition and posture changes of carcasses. This article explicates the succession of sarcophagus beetles on carrion and its influencing factors, and introduces the application and prospects of sarcophagus beetles in forensic entomology. Although few researches focus on sarcophagus beetles at present, it is believed that more and more forensic scientists will pay attention to sarcophagus beetles' application in forensic identification.

Besouros , Entomologia/métodos , Medicina Legal/métodos , Mudanças Depois da Morte , Animais , Besouros/classificação , Besouros/crescimento & desenvolvimento , Comportamento Alimentar , Humanos , Larva/crescimento & desenvolvimento , Estágios do Ciclo de Vida , Temperatura Ambiente , Fatores de Tempo