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1.
Zhongguo Zhong Yao Za Zhi ; 44(15): 3323-3329, 2019 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-31602890

RESUMO

To study the correlation between ultra high performance liquid chromatography( UPLC) fingerprint of Smilax china and its anti-pelvic inflammatory effect,and to explore the pharmacodynamic material basis of S. china against pelvic inflammatory disease.UPLC fingerprints of 10 batches of S. china from different habitats were established,and the values of SOD,MDA,TNF-α,and IL-6 in rats with pelvic inflammation were measured. The weight of each single pharmacodynamics index to the total efficacy was determined by analytic hierarchy process,and the contribution of each peak in fingerprints to the each single pharmacodynamics index and total efficacy was analyzed by the grey relational analysis. Then the structures of chemical constituents at the identified peaks were confirmed by comparing with the reference substance. The 27 common characteristic peaks of UPLC fingerprints were all related to the anti-pelvic inflammation effect of S. china,of which 13 peaks were identified as peak 2( 3,5-dihydroxy-2-methylbenzoic acid-3-O-glucoside),peak 3( chlorogenic acid),peak 5( 2,7,4-trihydroxydihydroflavone-5-O-glucoside),peak 6( 7,4-dihydroxydihydroflavonol-5-O-glucoside),peak 7( taxifolin-7-O-glucoside),peak 9( taxifolin),peak 10( polydatin),peak 11( oxyresveratrol),peak 12( astilbin),peak15( resveratrol),peak 16( quercitrin),peak 18( engeletin) and peak 24( kaempferol). The correlation degree of 21 peaks and the total efficacy was greater than 0. 8,and the top 10 ranked by correlation degree were as follows: peak 1,3,7,19,18,17,4,11,16,and 21. The results showed that the anti-pelvic inflammation effect of S. china was achieved by the combined action of pharmacodynamic substances. In order to control the quality of S. china and its prepared slices more effectively,the index components of content detection should be selected reasonably.


Assuntos
Doença Inflamatória Pélvica/tratamento farmacológico , Extratos Vegetais/farmacologia , Smilax/química , Animais , China , Cromatografia Líquida de Alta Pressão , Feminino , Compostos Fitoquímicos/farmacologia , Ratos
2.
Zhongguo Zhong Yao Za Zhi ; 32(13): 1292-5, 2007 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-17879728

RESUMO

OBJECTIVE: To investigate the technological parameters of the purification process of total flavones from Smilax china with macroporous absorption resin. METHOD: The technical process for purification of total flavones with the optimum macroporous absorption resin was screened by yield of total flavones product. RESULT: The D140 macroporous absorption resin had the best separating efficiency when the flavones content in the liquid was 0.5 g x mL(-1) equivalent to raw material, the volume of drug 18 BV (resin bad volume) with the adsorption-power 2 BV x h(-1), and the volume of 60% (mL x mL(-1)) ethanol as eluant 5-10 BV (resin bad volume) with desorption-power 1 BV x h(-1). The obtained flavones product has total flavones recovery rate of 84.72%. CONCLUSION: The treatment of regenerated resin is easy, this method is advisable.


Assuntos
Flavonas/isolamento & purificação , Plantas Medicinais/química , Resinas Sintéticas/química , Smilax/química , Absorção , Flavonas/química , Rizoma/química , Tecnologia Farmacêutica/métodos
3.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 26(6): 608-10, 2004 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-15663216

RESUMO

OBJECTIVE: To evaluate the quality difference between Coptis chinensis planted with ecological techniques and shelf planted Coptis chinensis. METHODS: Ultraviolet-visible spectrophotometry, alcohol extract mensuration, moisture mensuration, and ash mensuration were used to determine the contents of total alkaloids, alcohol extract, water, and total ash of Coptis chinensis, which were planted in shelf, Rhus chinensis wood, M mulbery wood, corn wood, Magnolia officinalis wood, fruiter wood, shading net, and firry wood, respectively. RESULTS: The contents of total alkaloids and alcohol extract of Coptis chinensis Table planted with ecological techniques were higher than those of Coptis chinensis planted in shelf. The contents of water and total ash were less than 12% and 5%, respectively, which met the provisions of the pharmacopoeia. CONCLUSION: The quality of Coptis chinensis planted with ecological techniques is similar to that of Coptis chinensis planted in shelf. These ecological techniques for Coptis chinensis have become mature and practical.


Assuntos
Alcaloides/análise , Conservação dos Recursos Naturais , Coptis/crescimento & desenvolvimento , Plantas Medicinais/crescimento & desenvolvimento , Agricultura/métodos , Coptis/química , Ecossistema , Agricultura Florestal/métodos , Extratos Vegetais/análise , Plantas Medicinais/química , Controle de Qualidade , Água/análise
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