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1.
West Indian Med J ; 56(1): 22-5, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17621840

RESUMO

OBJECTIVE: Bacterial infection with organisms resistant to antibiotics have increased during the last few decades worldwide. Because of this increase, the authors decided to subject the essential oils from the stem, leaves and fruits of the four native Jamaica species of Bursera to microbial studies. METHODS: Steam distillate extracts from different parts of four native Jamaican spp of Bursera simaruba (Red Birch), Bursera lunanii (Black Birch), Bursera hollickii and Bursera aromatica (Siboney) were tested for their antibacterial activity against six common pathogens: Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylocococcus aureus, methicillin resistant Staphylococcus aureus (MRSA) and beta-haemolytic Streptococcus group A (BHSA) using a disk diffusion assay. RESULTS: The investigation revealed that extracts from two of the four plants tested were active against all the pathogens. These were extracts from the fruits and stems of B. simaruba and those from the fruit of B. lunanii. CONCLUSION: This study gives credence to the ongoing search for locally available plants whose extracts possess significant antimicrobial activity. This may be useful in the development of naturally derived pharmaceuticals.


Assuntos
Infecções Bacterianas/tratamento farmacológico , Bursera , Fitoterapia , Extratos Vegetais , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Frutas , Humanos , Caules de Planta
2.
West Indian med. j ; 56(1): 22-25, Jan. 2007.
Artigo em Inglês | LILACS | ID: lil-471842

RESUMO

OBJECTIVE: Bacterial infection with organisms resistant to antibiotics have increased during the last few decades worldwide. Because of this increase, the authors decided to subject the essential oils from the stem, leaves and fruits of the four native Jamaica species of Bursera to microbial studies. METHODS: Steam distillate extracts from different parts of four native Jamaican spp of Bursera simaruba (Red Birch), Bursera lunanii (Black Birch), Bursera hollickii and Bursera aromatica (Siboney) were tested for their antibacterial activity against six common pathogens: Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylocococcus aureus, methicillin resistant Staphylococcus aureus (MRSA) and beta-haemolytic Streptococcus group A (BHSA) using a disk diffusion assay. RESULTS: The investigation revealed that extracts from two of the four plants tested were active against all the pathogens. These were extracts from the fruits and stems of B. simaruba and those from the fruit of B. lunanii. CONCLUSION: This study gives credence to the ongoing search for locally available plants whose extracts possess significant antimicrobial activity. This may be useful in the development of naturally derived pharmaceuticals.


Assuntos
Humanos , Bursera , Infecções Bacterianas/tratamento farmacológico , Fitoterapia , Extratos Vegetais , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Frutas , Caules de Planta
3.
Crit Care Clin ; 13(2): 287-98, 1997 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9107508

RESUMO

Southeast Asia is the world's region of most rapid economic growth. The countries in the region vary widely in annual per capita income and health expenditure. In the less wealthy countries, intensive care must compete for resources with basic public health programs and primary care, limiting public sector resources. In the wealthier countries and private hospitals in the region, intensive care units are well established but the organizational structure is still evolving, and there are few full-time intensivists. Most countries now have a Society of Intensive or Critical Care Medicine. Specialist training and examination systems for Intensive Care are established in Hong Kong, Taiwan, and the Philippines.


Assuntos
Cuidados Críticos/organização & administração , Unidades de Terapia Intensiva/organização & administração , Medicina , Especialização , Ásia Sudeste , Extremo Oriente , Custos de Cuidados de Saúde , Humanos , Pesquisa , Sociedades Médicas
4.
Crit Care Med ; 22(5): 789-95, 1994 May.
Artigo em Inglês | MEDLINE | ID: mdl-8181287

RESUMO

OBJECTIVE: To measure the clinical effects of dopexamine on systemic and splanchnic perfusion in critically ill patients. DESIGN: Prospective study. SETTING: General intensive care unit. PATIENTS: Ten patients with sepsis syndrome, acute respiratory failure, and at least one other organ system in failure. The median age of the patients was 62.5 yrs (range 29 to 78), and the median admission Acute Physiology and Chronic Health Evaluation (APACHE) II score was 24 points (range 14 to 38). INTERVENTIONS: Timed infusion of dopexamine to a maximum dose of 6 micrograms/kg/min. MEASUREMENTS AND MAIN RESULTS: Systemic hemodynamics and oxygen transport variables were obtained from measurements after arterial and pulmonary artery catheterization. Gastric intramucosal pH and hepatic blood flow/function measurements were made by tonometry and indocyanine green clearance, respectively. All measurements were made before dopexamine infusion, after 1 hr of dopexamine infusion, and again 1 hr after the infusion ended. Cardiac index increased with dopexamine from a baseline median of 4.0 L/min/m2 (range 1.2 to 5.5) to 4.8 L/min/m2 (range 1.5 to 8.03) (p < .01), and returned to its previous level 1 hr after the infusion ended (median 4.0 L/min/m2 [range 1.4 to 5.8], p < .01). During dopexamine infusion, gastric intramucosal pH improved significantly from a median baseline level of 7.21 (range 7.04 to 7.50) to 7.28 (range 7.13 to 7.46, p < .05). This improvement in gastric intramucosal pH was maintained (median 7.36 [range 7.13 to 7.46]) after the infusion ended. Indocyanine green half-life decreased but not significantly with dopexamine (medians before and during the infusion were 6.6 and 6.3 mins, respectively). Indocyanine green half-life increased significantly 1 hr after the infusion ended (median 7.4 mins [range 4.4 to 14.8], p < .05), and changes in cardiac index correlated with changes in indocyanine green half-life (Rs2 = 0.60, p < .001). Changes in gastric intramucosal pH were unrelated to all other measurements. CONCLUSIONS: Dopexamine improves gastric intramucosal pH, and thus, splanchnic oxygenation. This improvement in gastric intramucosal pH appears to be independent of dopexamine's systemic effects.


Assuntos
Dopamina/análogos & derivados , Hemodinâmica/efeitos dos fármacos , Circulação Hepática/efeitos dos fármacos , Insuficiência de Múltiplos Órgãos/tratamento farmacológico , Insuficiência de Múltiplos Órgãos/fisiopatologia , Insuficiência Respiratória/tratamento farmacológico , Insuficiência Respiratória/fisiopatologia , Choque Séptico/tratamento farmacológico , Choque Séptico/fisiopatologia , Circulação Esplâncnica/efeitos dos fármacos , Vasodilatadores/farmacologia , Doença Aguda , Adulto , Idoso , Gasometria , Estado Terminal , Dopamina/farmacologia , Dopamina/uso terapêutico , Feminino , Determinação da Acidez Gástrica , Mortalidade Hospitalar , Humanos , Concentração de Íons de Hidrogênio , Verde de Indocianina/farmacocinética , Infusões Intravenosas , Masculino , Taxa de Depuração Metabólica , Pessoa de Meia-Idade , Insuficiência de Múltiplos Órgãos/sangue , Insuficiência de Múltiplos Órgãos/mortalidade , Consumo de Oxigênio/efeitos dos fármacos , Estudos Prospectivos , Insuficiência Respiratória/sangue , Insuficiência Respiratória/mortalidade , Índice de Gravidade de Doença , Choque Séptico/sangue , Choque Séptico/mortalidade , Síndrome , Vasodilatadores/uso terapêutico
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