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1.
Sci Rep ; 10(1): 2811, 2020 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-32071392

RESUMO

The development of machine-transplanted hybrid rice is a feasible approach to meet the needs of both high grain yield and high labor efficiency in China, but limited information is available on the critical plant traits associated with high grain yields in machine-transplanted hybrid rice. This study was carried out to identify which type of culms (i.e., main stems and primary and secondary tillers) and which yield components of this culm are critical to achieving high grain yields in machine-transplanted hybrid rice. Field experiments were conducted with two hybrid rice cultivars grown under two densities of machine transplanting in two years. Results showed that total grain yield of main stems and primary and secondary tillers was not significantly affected by cultivar but was significantly affected by density and year. Averaged across cultivars, densities, and years, main stems and primary and secondary tillers contributed about 15%, 50%, and 35% to total grain yield, respectively. Total grain yield was not significantly related to grain yields of main stems and secondary tillers but was positively and significantly related to grain yield of primary tillers. Approximately 85% of the variation in total grain yield was explained by grain yield of primary tillers, which was positively and significantly related to primary-tiller panicles per m2 but not to spikelets per panicle, spikelet filling percentage, or grain weight of primary tillers. Based on these results, it is concluded that primary-tiller panicle number is essential for achieving high grain yields in machine-transplanted hybrid rice.

2.
J Med Chem ; 63(4): 1660-1670, 2020 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-31990537

RESUMO

Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL will lead to sustained plasma high-density lipoprotein cholesterol (HDL-C) increase and, potentially, a reduced cardiovascular disease (CVD) risk. Herein, we describe the discovery of a series of oxadiazole ketones, which upon optimization, led to the identification of compound 12. Compound 12 was evaluated in a mouse pharmacodynamics (PD) model and demonstrated a 56% increase in plasma HDL-C. In a mouse reverse cholesterol transport study, compound 12 stimulated cholesterol efflux by 53% demonstrating HDL-C functionality.

3.
PLoS One ; 14(11): e0224935, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31697760

RESUMO

High yields of mechanized intensive rice-based cropping systems, e.g. double-season cropping using early- and late-season rice, are important to ensure national food security in China. However, few studies addressing the relationship between grain weight and grain yield of early-season rice under machine-transplanted conditions. A field experiment was conducted to determine the critical grain-filling characteristics and related physiological aspects that contribute to high grain weight in machine-transplanted early-season rice. The results showed that grain yield was significantly positively correlated with grain weight but not with panicles per m2, spikelets per panicle, and spikelet-filling percentage. Furthermore, this study demonstrated that there was a significant positive correlation between grain weight and mean grain-filling rate, which was significantly positively correlated with harvest index and grain cytokinin content. These results indicate that high grain-filling rate driven by good transport of assimilates to grains and strong grain sink strength is responsible for high grain weight in machine-transplanted early-season rice.

4.
Bioorg Med Chem Lett ; 29(20): 126673, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31519373

RESUMO

A series of benzothiazoles with a cyano group was synthesized and evaluated as endothelial lipase (EL) inhibitors for the potential treatment of cardiovascular diseases. Efforts to reduce molecular weight and polarity in the series led to improved physicochemical properties of these compounds, as well as selectivity for EL over hepatic lipase (HL). As a benchmark compound, 8i demonstrated potent EL activity, an acceptable absorption, distribution, metabolism and elimination (ADME) profile and pharmacokinetic (PK) exposure which allowed further evaluation in preclinical animal efficacy studies.

5.
PLoS One ; 14(7): e0220651, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31365589

RESUMO

Translocation of biomass produced during pre-heading to grains is a determinant of grain yield, but also plays an important role in adaptation to unfavorable environments during post-heading in rice. In this study, field experiments were conducted to determine the critical factors that regulate biomass translocation in rice. Biomass translocation and production characteristics of two rice hybrids (Guiliangyou 2 and Y-liangyou 1) were compared between two site-year environments (Naning-2014 and Yongan-2018). Results showed that biomass translocation parameters (biomass translocation amount and rate and contribution of biomass translocation to filled grain weight) and ratio of biomass production during pre-heading to post-heading (BPpre/BPpost ratio) decreased in Guiliangyou 2 but increased in Y-liangyou 1 with the environment change from Nanning-2014 to Yongan-2018. The decreased BPpre/BPpost in Guiliangyou 2 was attributable to increased biomass production during post-heading (BPpost), while the increased BPpre/BPpost ratio in Y-liangyou 1 was due to increased biomass production during pre-heading (BPpre). Higher cumulative incident solar radiation and larger diurnal temperature variation were responsible for the increased BPpost in Guiliangyou 2 and the increased BPpre in Y-liangyou 1 grown in Yongan in 2018 compared to in Nanning in 2014. The results of this study indicate that changes in biomass translocation and production with environment (climate) in rice are dependent on genotype and that the BPpre/BPpost ratio is an important factor regulating biomass translocation in rice.

6.
Front Oncol ; 9: 729, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31448232

RESUMO

Objective: To develop a prognostic signature for patients with bladder cancer (BC). Methods: We identified differentially expressed miRNAs between normal bladder tissue and bladder cancer in the TCGA-BCLA dataset and evaluated prognostic values of these miRNAs. Then, a 21-miRNA signature was constructed based on the results of Cox proportional hazards regression model. Furthermore, functional enrichment analyses were conducted to explore the potential effects of the target genes of these 21 miRNAs. Results: Seventy six differentially expressed miRNAs were identified, among which 21 miRNAs including hsa-let-7c, mir-143, mir-944, mir-192, mir-590, mir-490, mir-141, mir-93, mir-1-2, mir-200c, mir-133a-1, mir-1-1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. The results of Chi-square test and multivariable logistic regression analysis showed that the 21-miRNA signature was significantly associated with the diagnosis type and T stage of bladder cancer. Univariate and multivariable survival analyses indicated that the 21-miRNA signature was an independent factor in predicting the overall survival of patients with bladder cancer. The results of functional enrichment analysis suggested that the target genes of these 21 miRNAs were mostly enriched in critical cancer-related biological processes and pathways, and the PPI network suggested that 60 targeted genes interacted with a minimum of 30 genes were at the hub of the whole network. In addition, we performed a multivariate nomogram and decision curve analysis (DCA) to evaluate the clinical application of 21-microRNA signature. Conclusion: We introduced a 21-miRNA signature which was associated the prognosis of patients of bladder cancer, and inspirational ideas for the future basic and clinical exploration.

8.
ACS Med Chem Lett ; 10(6): 911-916, 2019 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-31223447

RESUMO

Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmaceutical properties concomitant with retaining the safety, efficacy, and pharmacokinetic (PK) profile. A structure-activity relationship observed in the DPPE series was extended to the corresponding analogs in the more potent TPE series, and further optimization resulted in the identification of 2-amino-N-((R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethyl)-4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanamide (13). Compound 13 demonstrated no significant changes in either mean arterial blood pressure or heart rate in telemetry rats, had an excellent PK profile, and demonstrated robust efficacy in human CETP/apo-B-100 dual transgenic mice and in hamsters.

9.
Bioorg Med Chem Lett ; 29(15): 1918-1921, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31176700

RESUMO

A low level of high density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL reduces inflammation and plays a central role in reverse cholesterol transport, where cholesterol is removed from peripheral tissues and atherosclerotic plaque. One approach to increase plasma HDL is through inhibition of endothelial lipase (EL). EL hydrolyzes phospholipids in HDL resulting in reduction of plasma HDL. A series of benzothiazole sulfone amides was optimized for EL inhibition potency, lipase selectivity and improved pharmacokinetic profile leading to the identification of Compound 32. Compound 32 was evaluated in a mouse pharmacodynamic model and found to show no effect on HDL cholesterol level despite achieving targeted plasma exposure (Ctrough > 15 fold over mouse plasma EL IC50 over 4 days).

10.
Sci Rep ; 9(1): 6818, 2019 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-31048747

RESUMO

Growing oilseed rape in the fallow season may be a feasible alternative to growing green manure (e.g. Chinese milk vetch) for improving rice productivity. The objective of this study was to determine the yield performance of machine-transplanted double-season rice (i.e. early- and late-season rice) grown following oilseed rape. Field experiments were conducted to compare machine-transplanted double-season rice grown following oilseed rape, Chinese milk vetch and fallow (i.e. no crop) at Hengyang and Yueyang, Hunan Province, China in three cropping cycles from 2014 to 2017. Results showed that machine-transplanted double-season rice grown following oilseed rape and Chinese milk vetch produced similar grain yield, which was higher than that grown following fallow across two sites and three cropping cycles. The higher grain yield of machine-transplanted double-season rice grown following oilseed rape and Chinese milk vetch was attributable to improvement in both sink size (spikelet number per m2) and source capacity (total biomass). However, the reasons for the improved sink size of machine-transplanted double-season rice grown following oilseed rape and Chinese milk vetch were not entirely the same. Growing oilseed rape increased panicle size (spikelet number per panicle) and panicle number in early- and late-season rice, respectively, while growing Chinese milk vetch increased panicle number in both the early- and late-season rice. Our study suggests that growing oilseed rape in the fallow season is a useful alternative strategy for improving productivity of machine-transplanted double-season rice.

11.
PLoS One ; 14(3): e0213075, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30893321

RESUMO

In order to solve the problem of labor shortage in double-season rice production areas, machine transplanting, as opposed to manual transplanting, has become the more popular alternative method in rice cultivation. However, the most existing late rice cultivars are not suitable for machine double-season rice cultivation due to their long duration of growth. Therefore, based on the previous studies we chose early season rice cultivars to meet the needs of machine double-season rice cultivation. In this study, field experiments were conducted during the late season in 2015 and 2016 in Liuyang County, Hunan Province, China. Grain yield and yield-related traits were compared among eight early-season cultivars (Liangyou 6, Lingliangyou 211, Lingliangyou 268, Zhuliangyou 819, Xiangzaoxian 32, Xiangzaoxian 42, Zhongjiazao 17, and Zhongzao 39) in 2015 and four cultivars (Lingliangyou 268, Zhuliangyou 819, Zhongjiazao 17, and Zhongzao 39) in 2016, selected from the highest yielding cultivars grown in 2015. Lingliangyou 268 produced 8-44% higher grain yield than did the other cultivars except Zhongjiazao17 in 2015. This higher grain yield was driven by grain weight and aboveground biomass. The greater aboveground biomass in Lingliangyou 268 was mainly attributed to higher apparent radiation use efficiency (aboveground biomass/incident solar radiation). Our study suggests that improvement in grain weight and apparent radiation use efficiency were critical to the high grain yield of early-season rice cultivars grown in late season under machine transplanting conditions.


Assuntos
Produção Agrícola/instrumentação , Grão Comestível/crescimento & desenvolvimento , Oryza/crescimento & desenvolvimento , Endogamia , Melhoramento Vegetal , Estações do Ano
12.
J Cell Biochem ; 120(6): 9724-9736, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30582214

RESUMO

OBJECTIVES: Adamantinomatous craniopharyngiomas (adaCP) accounts for 5.6% to 15% of intracranial tumors. High expression of chemokine (C-X-C motif) ligand 12 (CXCL12, also known as stromal cell-derived factor 1 [SDF1]) and its receptor CXC receptor type 4 (CXCR4) are widespread in various malignancy via multiple signal transduction pathways. This study aims to investigate the mechanism of CXCL12/CXCR4 promoting proliferation, migration, and invasion of adaCP. METHODS: Quantitative real-time polymerase chain reaction, Western blot analysis, and immunohistochemistry were used to evaluate the expression of CXCL12/CXCR4 mRNA and protein in 10 human adaCP tissues. Three successfully primary cell lines were obtained from native mainly solid tumor specimens, and confirmed by the means of inverted contrast microscope directly and following hematoxylin and eosin staining. Immunofluorescence was used to detect protein expression in vivo for the verification of primary cell line. Proliferation, migration, and invasion assays were performed to assess the biological functional role of CXCL12/CXCR4 in adaCP. The signal pathways involved in the action of CXCL12/CXCR4 in adaCP were also evaluated. RESULTS: CXCL12 and CXCR4 were highly expressed in human adaCP samples. Primary adaCP cells were isolated and detected by the means of immunofluorescence for the detection of pan cytokeratin (pan-CK) and vimentin (VIM). Overexpression of CXCL12/CXCR4 significantly promoted the proliferation, migration, and invasion of primary adaCP cells. Moreover, cancer-promoting activity of CXCL12/CXCR4 is partially through its facilitation of PI3K/AKT signal pathway. CONCLUSIONS: Our data showed that CXCL12/CXCR4 promotes adaCP proliferation, migration, and invasion through PI3K/AKT signal pathway. These findings suggested that therapeutic strategies regulating CXCL12/CXCR4 expression may provide an effective treatment of adaCP.

13.
Medicine (Baltimore) ; 97(39): e11830, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30278482

RESUMO

To investigate the prognostic value of DHCR24 for patients with bladder cancer (BC). We used public bladder cancer microarray studies to evaluate the expression of DHCR24 between normal bladder tissues and BC cells, to investigate the relationship between the expression of DHCR24 and the clinical features of BC patients. Survival analysis was performed to investigate the correlation between DHCR24 expression and the survivals of BC patients. Gene set enrichment analysis was conducted to identify relevant mechanisms. The results showed that DHCR24 was up-regulated in BC cells compared with that in normal bladder tissues (P = .0389). Results of chi-square test suggested that BC patients in DHCR24 low expression group were proved to have better clinical characteristics (including tumor grade, disease progression, T staging, and N staging) as compared with those in DHCR24 low expression group (P < .0001, P = .002, P = .005, and P = .002, respectively). BC patients in DHCR24 low expression group were associated with better cancer-specific survival and overall survival (P < .0001 and P = .0008, respectively). DHCR24 might promote the proliferation of BC cells through several oncogenesis-associated biological processes (estrogen response, heme metabolism, P53 pathway, cholesterol homeostasis, mTORC1 signaling, peroxisome, xenobiotic metabolism, glycolysis, and protein secretion). Thus, DHCR24 might be a therapeutic target for patients with BC.


Assuntos
Biomarcadores Tumorais/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Oxirredutases atuantes sobre Doadores de Grupo CH-CH/metabolismo , Neoplasias da Bexiga Urinária/metabolismo , Idoso , Progressão da Doença , Feminino , Perfilação da Expressão Gênica/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Análise de Sobrevida , Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/mortalidade , Neoplasias da Bexiga Urinária/patologia
14.
Front Physiol ; 9: 1014, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30116199

RESUMO

Objectives: TP53 is an important tumor suppressor gene to maintain genomic integrity, and its mutations increase the susceptibility to oral carcinoma. Previous published studies have reported the relation of TP53 codon 72 polymorphism with the risk of oral carcinoma, but the results remain controversial and inconclusive. Methods: We therefore utilized meta-analysis based on a comprehensive search in PubMed, EMBASE, and Google of Scholar databases up to August 19, 2017. Results: Total 3,525 cases and 3,712 controls from 21 case-control studies were selected. We found no significant association between TP53 codon 72 polymorphism and oral carcinoma susceptibility in all genetic contrast models, including subgroup analysis based on control source and ethnicity. Furthermore, TP53 codon 72 polymorphism was not significant associated with oral carcinoma susceptibility in tobacco or alcohol use, and HPV infection status. Our results were confirmed by sensitivity analysis and no publication bias was found. Conclusions: Taken together, our data indicate that TP53 codon 72 polymorphism is not associated with the susceptibility to oral carcinoma.

15.
ACS Med Chem Lett ; 9(7): 673-678, 2018 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-30034599

RESUMO

Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide (5; EL IC50 = 61 nM, ELHDL IC50 = 454 nM). Deck mining identified a related hit, N-(3-(3,4-dichlorophenyl)propyl)-4-hydroxy-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide (6a; EL IC50 = 41 nM, ELHDL IC50 = 1760 nM). Both compounds were selective against lipoprotein lipase (LPL) but nonselective versus hepatic lipase (HL). Optimization of compound 6a for EL inhibition using HDL as substrate led to N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide (7c; EL IC50 = 148 nM, ELHDL IC50 = 218 nM) having improved PK over compound 6a, providing a tool molecule to test for the ability to increase HDL-cholesterol (HDL-C) levels in vivo using a reversible EL inhibitor. Compound 7c did not increase HDL-C in vivo despite achieving plasma exposures targeted on the basis of enzyme activity and protein binding demonstrating the need to develop more physiologically relevant in vitro assays to guide compound progression for in vivo evaluation.

16.
Beilstein J Nanotechnol ; 9: 1770-1781, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29977710

RESUMO

Novel hexagonal nanoplates (NPLs) comprised of mesoporous carbon containing imbedded magnetic Co nanoparticles (CoAl2O4 phase) are prepared through direct carbonization of polydopamine (PDA)-coated CoAl layered double hydroxide (LDH). A uniform PDA coating initially covers the surface of LDH by dopamine self-polymerization under mild conditions. Well-dispersed Co nanoparticles are formed in the NPLs by the partial reduction of cobalt from Co2+ to Co0 with surface carbon during the heat treatment process. The surface morphology and specific surface area of the as-prepared NPLs can be tailored by adjusting the initial dopamine concentration and carbonization temperature. The mesoporous NPLs exhibit excellent sorption of rhodamine B (RhB) dye and fast magnetic separation in aqueous solution. Over 95% of RhB can be adsorbed within 2 min and the adsorption reaches equilibrium after about 30 min. The maximum adsorption capacity approaches 172.41 mg/g. After regeneration, this adsorbent can be recycled easily by magnetic separation and still possess good adsorption capacity for RhB removal, even after five cycles.

17.
Anal Chem ; 90(14): 8592-8599, 2018 07 17.
Artigo em Inglês | MEDLINE | ID: mdl-29939012

RESUMO

Ionic current rectification (ICR) phenomena within dual glass pipettes are investigated for the first time. We demonstrate that the ionic flow presents different behaviors in dual nano- and micropipettes when the two channels are filled with the same electrolyte KCl and hung in air. Bare dual nanopipettes cannot rectify the ionic current because of their geometric symmetry, but the ICR can be directly observed based on bare dual micropipettes. The phenomena based on dual micropipettes could be explained by the simulation of the Poisson-Nernst-Plank equation. After modification with different approaches, the dual nanopipettes have asymmetric charge patterns and show various ICR behaviors. They have been successfully employed to fabricate various nanodevices, such as ionic diodes and bipolar junction transistors. Due to the simple and fast fabrication with high reproducibility, these dual pipettes can provide a novel platform for controlling ionic flow in nano- and microfluidics, fabrication of novel nanodevices, and detection of biomolecules.

18.
Opt Express ; 26(9): 11250-11264, 2018 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-29716049

RESUMO

This work presents a novel nondestructive cavity pressure characterization approach in microinjection molding (µIM) through measuring 3D part thickness distributions. For this purpose, a plano lens was designed and experiments based on Taguchi method were conducted. Both overall and local lens thickness distributions under various process conditions were analyzed in terms of their relevance with the cavity pressure during molding. Unexpectedly, a reliable linear regression model was developed fulfilling nondestructive multi-point or even continuous cavity pressure characterization with the overall lens thickness distribution. Furthermore, the topography of the constructed 3D thickness surface was found to depend on both process condition and measuring position. Finally, the process conditions were optimized for obtaining uniform distributions of both 3D thickness and cavity pressure.

19.
Langmuir ; 34(26): 7738-7743, 2018 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-29806943

RESUMO

Monodisperse patchy silica nanoparticles (PSNPs) less than 100 nm are prepared based on the seed-regrowth method using a poly(ethylene oxide) (PEO)-poly(propylene oxide) (PPO)-PEO-type block copolymer as a surface modifier. Well-defined patches are controllably synthesized through area-selective deposition of silica onto the surface of seeds. After colloidal PSNPs are further modified with trimethylchlorosilane, the advancing and receding contact angles of water for PSNPs are 168 ± 2° and 167 ± 2°, respectively. The superhydrophobic and transparent coatings on the various types of substrates are obtained by a simple drop-casting procedure. Additionally, almost the same superhydrophobicity can be achieved by using colloidal PSNPs via redispersing the powder of superhydrophobic PSNPs in ethanol.

20.
Brain Res ; 1692: 154-162, 2018 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-29782850

RESUMO

Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and molecular mechanism in glioblastoma is poorly understood. In this study, our findings demonstrated that protein and mRNA levels of HDAC1 were increased in glioma cell lines and glioma tissues compared to normal glial cell lines and non-neoplastic brain tissues, respectively. Furthermore, HDAC1 knockdown cells displayed decreased proliferation and invasion capabilities, whereas HDAC1 overexpressing glioblastoma cells displayed more proliferation and invasion capabilities in vitro. These novel outcomes suggested that knockdown of HDAC1 possibly suppressed the expression of phosphorylated AKT (p-AKT) and phosphorylated ERK (p-ERK) proteins, while overexpression of HDAC1 significantly increased p-AKT and p-ERK protein in glioblastoma cells. In addition, knockdown of HDAC1 repressed subcutaneous tumor growth in vivo, and led to down-regulation of p-AKT and p-ERK protein in U87 MG xenograft tumors. For the first time, we have demonstrated that HDAC1 promotes proliferation and invasion in glioblastoma cells by activating PI3K/AKT and MEK/ERK signaling pathways in vitro and in vivo. These results suggest that HDAC1 may be a novel biomarker and potential therapeutic target in glioblastoma.


Assuntos
Neoplasias Encefálicas/patologia , Proliferação de Células/fisiologia , Regulação Neoplásica da Expressão Gênica/fisiologia , Glioblastoma/patologia , Histona Desacetilase 1/metabolismo , Transdução de Sinais/fisiologia , Adolescente , Adulto , Idoso , Animais , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Feminino , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Histona Desacetilase 1/genética , Humanos , Antígeno Ki-67/metabolismo , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Sistema de Sinalização das MAP Quinases/fisiologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Pessoa de Meia-Idade , Invasividade Neoplásica , Fosfatidilinositol 3-Quinases , Proteínas Proto-Oncogênicas c-akt/metabolismo , RNA Mensageiro/metabolismo , RNA Interferente Pequeno/genética , RNA Interferente Pequeno/metabolismo , Transdução de Sinais/efeitos dos fármacos , Transfecção , Adulto Jovem
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