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1.
Signal Transduct Target Ther ; 6(1): 342, 2021 09 16.
Artigo em Inglês | MEDLINE | ID: mdl-34531370

RESUMO

While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. We performed single-cell transcriptome and T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, and severe patients with healthy controls. Asymptomatic patients displayed increased CD56briCD16- natural killer (NK) cells and upregulation of interferon-gamma in effector CD4+ and CD8+ T cells and NK cells. They showed more robust TCR clonal expansion, especially in effector CD4+ T cells, but lack strong BCR clonal expansion compared to moderate patients. Moreover, asymptomatic patients have lower interferon-stimulated genes (ISGs) expression in general but large interpatient variability, whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease. Our data provide evidence of different immune signatures to SARS-CoV-2 in asymptomatic infections.


Assuntos
COVID-19 , Portador Sadio/imunologia , Linfócitos/imunologia , SARS-CoV-2/imunologia , Análise de Célula Única , Transcriptoma/imunologia , Adolescente , Adulto , COVID-19/genética , COVID-19/imunologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Receptores de Antígenos de Linfócitos B/genética , Receptores de Antígenos de Linfócitos B/imunologia , Receptores de Antígenos de Linfócitos T/genética , Receptores de Antígenos de Linfócitos T/imunologia , SARS-CoV-2/genética
3.
Pharmacol Res ; 172: 105857, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34461223

RESUMO

Opioid relapse is generally caused by the recurrence of context-induced memory reinstatement of reward. However, the internal mechanisms that facilitate and modify these processes remain unknown. One of the key regions of the reward is the nucleus accumbens (NAc) which receives glutamatergic projections from the dorsal hippocampus CA1 (dCA1). It is not yet known whether the dCA1 projection to the NAc shell regulates the context-induced memory recall of morphine. Here, we used a common model of addiction-related behavior conditioned place preference paradigm, combined with immunofluorescence, chemogenetics, optogenetics, and electrophysiology techniques to characterize the projection of the dCA1 to the NAc shell, in context-induced relapse memory to morphine. We found that glutamatergic neurons of the dCA1 and gamma aminobutyric acidergic (GABA) neurons of the NAc shell are the key brain areas and neurons involved in the context-induced reinstatement of morphine memory. The dCA1-NAc shell glutamatergic input pathway and the excitatory synaptic transmission of the dCA1-NAc shell were enhanced via the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) when mice were re-exposed to environmental cues previously associated with drug intake. Furthermore, chemogenetic and optogenetic inactivation of the dCA1-NAc shell pathway decreased the recurrence of long- and short-term morphine-paired context memory in mice. These results provided evidence that the dCA1-NAc shell glutamatergic projections mediated the context-induced memory recall of morphine.

4.
J Nanosci Nanotechnol ; 21(12): 6007-6015, 2021 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-34229798

RESUMO

Occupational exposure to indium oxide and indium containing particles has been associated with the development of severe lung diseases called "indium lung." According to the survey of occupational hygiene, indium oxide nanoparticles have been identified in the workplaces and the lungs of workers. To date, the potential mechanism of the pneumotoxicity has been poorly understood and no effective therapies are available against "indium lung." Our present study reported that the exposure of indium oxide nanoparticles damaged lung epithelial cells and alveolar macrophages and induced pulmonary alveolar proteinosis and inflammation in rats. In the 8-week post-exposure period, the indium oxide nanoparticles still mostly accumulated in the lungs and then persistently release indium ions in two months after exposure. In vitro, the epithelial cells show the greater potential for release of indium ions from indium oxide nanoparticles compared with the macrophages. EDTA-2Na, a metal chelating agent expected to remove the indium ions, was found to significantly reduced the cytotoxicity of indium oxide nanoparticles. Herein, the pneumotoxicity may be attributed to the slow and incremental release of indium ions from indium oxide nanoparticles primary dissolved by epithelial cells and macrophages, at least partially. The study may provide some insights to the pathogenicity mechanisms of "indium lung" and some clues against the health hazards of occupational inhaled indium oxide nanoparticles at the workplaces.


Assuntos
Índio , Nanopartículas , Animais , Células Epiteliais , Índio/toxicidade , Íons , Pulmão , Macrófagos , Nanopartículas/toxicidade , Ratos
5.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 29(3): 715-719, 2021 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-34105462

RESUMO

OBJECTIVE: To investigate the value of CD44+ mononuclear cells (MNC) and spleen stiffness measurement (SSM) in minimal residual disease (MRD) in acute myeloid leukemia (AML) and its prognosis. METHODS: Flow cytometry was used to detected the proportion of CD44+ and CD24+ MNC in 44 AML patients after induction chemotherapy. The SSM was tested by FS. The value of MNC and SSM in MRD and its prognosis was explored. RESULTS: The percentage of CD44+ MNC and SSM in MRD positive group were significantly higher than those in MRD negative group (P<0.05). In MRD positive group, there were positive correlation between CD44+ MNC, SSM and MRD level (r=0.998, r=0.939, P<0.05). The median EFS and OS in HCD44+ MNC and HSSM groups were significantly shorter than those in LCD44+ MNC and LSSM (P<0.05). CD24+ MNC showed no association with MRD and its prognosis. CONCLUSION: HCD44+ MNC and HSSM may be used to predict high level MRD and poor prognosis.


Assuntos
Leucemia Mieloide Aguda , Baço , Citometria de Fluxo , Humanos , Receptores de Hialuronatos , Quimioterapia de Indução , Leucemia Mieloide Aguda/tratamento farmacológico , Neoplasia Residual , Prognóstico
6.
Artigo em Inglês | MEDLINE | ID: mdl-34142324

RESUMO

The composition and structure of dissolved organic matter (DOM) play vital roles in the material cycle of river ecosystems. Based on ultraviolet-visible absorption spectroscopy, excitation-emission matrix fluorescence spectroscopy, and ultrahigh-resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry technology, this study comprehensively characterized the composition and structure of DOM in the overlying water of the Chaobai River in order to determine the potential environmental impact of DOM on the water quality. The results showed that the DOM content of the overlying water in the Chaobai River was between 10.94 and 28.13 mg/L. The main DOM component of the overlying water was humus (70.94%). The relative abundance of CHOS compounds in the Chaobai River was lower than Maozhou River (urbanized river) and significantly higher than Xiangxi Bay (suburban river). In addition, the DOM composition and structure of the overlying water were closely related to anthropogenic input, microbial activity, and phytoplankton. In particular, chlorophyll a can indirectly reflect fresh autochthonous DOM content and composition in the overlying water. The results of this study further reveal the characteristics of suburban rivers and provide theoretical basis and guidance for the water quality evaluation and pollution control of the Chaobai River and other suburban rivers worldwide.

7.
J Hazard Mater ; 417: 125958, 2021 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-34020354

RESUMO

The extensive use of graphene oxide (GO) results in its inevitable entry into the environment, raising risks to the environment, especially the ecological risks when coexisting with other contaminants. Nevertheless, how GO affects the biological behavior of Cd in plants remains poorly understood. Here, we report that the transcript levels of Cd transporters, including OsIRT1, OsIRT2, OsNramp1, OsNramp5, and OsHMA2, were decreased by 56-96% in Cd-stressed rice seedlings with exposure to 400 mg L-1 GO compared with those without GO exposure. The in situ non-invasive microelectrodes test revealed that GO clearly reduced the net Cd influx of rice roots. Thus, GO exposure decreased the level of Cd in rice seedlings by approximately 60%, compared with the GO-free condition. However, the analyses of biomass, chlorophyll fluorescence parameters and Evans blue staining, indicated that GO had adverse effects on the robustness of plants under the Cd co-contaminated condition. Taken together, although GO reduced the accumulation of Cd in rice seedlings, it still negatively affected plant growth. Therefore, the positive and negative impacts of GO on crop production are of concern. Our findings provide new information for establishing a wider phytotoxicity evaluation system for the safe manufacture and use of GO.


Assuntos
Grafite , Oryza , Cádmio/toxicidade , Grafite/toxicidade , Raízes de Plantas , Plântula
8.
Inquiry ; 58: 469580211018284, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34032161

RESUMO

The effect of exercise intervention on balance capacity among type 2 diabetes mellitus (T2DM) patients has not been evaluated. The objective of this systematic review and meta-analysis is to investigate the effect of exercise intervention on balance capacity among T2DM patients compared to the control group (usual care, waitlist, no-treatment, education). We conducted a comprehensive literature search through PubMed, EMBASE, Physiotherapy Evidence Database (PEDro), Cochrane library, Web of Science (WOS) from inception to August 2020. The literature language was limited to English. Randomized controlled trials (RCTs) or quasi-experimental (Q-E) trials that examined the effect of exercise intervention on balance capacity among T2DM patients were included. We used the standard methods of meta-analysis to evaluate the outcomes of exercise intervention for balance capacity of T2DM patients. A total of 14 trials (11 RCTs and 3 Q-E trials) involving 883 participants were eligible. The meta-analysis of some studies demonstrated that exercise intervention could significantly improve Berg Balance Scale (BBS) (MD = 2.56; 95%CI [0.35, 4.77]; P = .02), SLST (Single Leg Stance Test) under the eyes-open (EO) condition (MD = 3.63; 95%CI [1.79, 5.47]; P = .0001) and eyes-close (EC) condition (MD = 0.41; 95%CI [0.10, 0.72]; P = .01) compared to control group. There was no significant difference in Time Up and Go Test (TUGT) (MD = -0.75; 95%CI [-1.69, 0.19]; P = .12) and fall efficacy (SMD = -0.44; 95%CI [-0.86, -0.01]; P = .05). Narrative review of some studies indicated that exercise intervention could improve postural stability measured by Sensory Organization Test (SOT) and Center of Pressure (COP) variables, etc. This systematic review and meta-analysis summarized that exercise intervention could improve balance capacity in T2DM patients. However, further studies with high quality are required to evaluate its effect.

10.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 29(2): 348-325, 2021 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-33812398

RESUMO

OBJECTIVE: To detect the relationship between leukocytes derived microparticle (CD45+ MP) and minimal residual disease (MRD) and prognosis of acute myeloid leukemia (AML). METHODS: The expression of CD45+ MP, CD44+ MP and CD24+ MP in peripheral blood of 47 AML patients at the time after induction chemotherapy were detected by using flow cytometry, and the relationship between MP, MRD and prognosis were analyzed. RESULTS: The percentages of CD45+ MP, CD44+ MP and CD24+ MP in MRD positive group were significantly higher than those in MRD negative group. In MRD positive group, there were positive correlation between CD45+ MP, CD44+ MP, CD24+ MP and MRD level. The AUC of CD45+ MP, CD44+ MP, CD24+ MP in predicting positive MRD was 0.949, 0.782, and 0.817, respectively. The EFS and OS in HCD45+ MP, HCD44+ MP and HCD24+ MP groups were significantly shorter than low level group. CONCLUSION: High level of CD45+ MP, CD44+ MP, CD24+ MP can be used to predict high level MRD and poor prognosis.


Assuntos
Leucemia Mieloide Aguda , Citometria de Fluxo , Humanos , Leucócitos , Neoplasia Residual , Prognóstico
11.
Mol Ecol Resour ; 21(5): 1732-1744, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33665976

RESUMO

Detecting genetic regions under selection in structured populations is of great importance in ecology, evolutionary biology and breeding programmes. We recently proposed EigenGWAS, an unsupervised genomic scanning approach that is similar to F ST but does not require grouping information of the population, for detection of genomic regions under selection. The original EigenGWAS is designed for the random mating population, and here we extend its use to inbred populations. We also show in theory and simulation that eigenvalues, the previous corrector for genetic drift in EigenGWAS, are overcorrected for genetic drift, and the genomic inflation factor is a better option for this adjustment. Applying the updated algorithm, we introduce the new EigenGWAS online platform with highly efficient core implementation. Our online computational tool accepts plink data in a standard binary format that can be easily converted from the original sequencing data, provides the users with graphical results via the R-Shiny user-friendly interface. We applied the proposed method and tool to various data sets, and biologically interpretable results as well as caveats that may lead to an unsatisfactory outcome are given. The EigenGWAS online platform is available at www.eigengwas.com, and can be localized and scaled up via R (recommended) or docker.


Assuntos
Genoma , Internet , Seleção Genética , Software , Algoritmos , Visualização de Dados , Deriva Genética , Genômica
12.
Phys Chem Chem Phys ; 23(11): 6632-6640, 2021 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-33709091

RESUMO

Single-atom catalysts (SACs) have received intense attention owing to their maximum utilization efficiency of metal atoms and high catalytic activity. Although SACs possess many merits, such as high activity, selectivity and stability in photocatalysis, the difficulty of fabricating atomically dispersed atom catalysts with a high level of metal loading limits their practical applications. Here, a sulphur-doping strategy was proposed to enhance the incorporation of single Pt atoms in monolayer graphitic carbon nitride (g-C3N4), and the structural, electronic and optical properties were investigated through density functional theory (DFT) calculations. This work verified that SACs based on sulphur-doped monolayer g-C3N4 (S-g-C3N4) exhibit a lower band gap energy, higher photocatalytic oxidation ability, easier charge separation, lower oxidation state of Pt atoms and wider light absorption range. This work provides a promising path for fabricating efficient g-C3N4-based photocatalytic SACs.

13.
J Rehabil Med ; 53(3): jrm00165, 2021 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-33594445

RESUMO

OBJECTIVE: The aim of this systematic review was to evaluate the effects of tai chi on metabolic control and body composition indicators in patients with type 2 diabetes mellitus. DESIGN: Systematic review and meta-analysis of existing literature. METHODS: Electronic resource databases were searched to collect eligible studies. Two reviewers selected studies and independently evaluated method-ological quality. RESULTS: Twenty-three studies were included in this meta-analysis. The pooled results showed that tai chi had significant effects in improving metabolic indices, such as fasting blood glucose (mean differ-ence (MD) = -1.04; 95% confidence interval (95% CI) -1.42 to 0.66; p < 0.01) and total cholesterol (MD = -0.50; 95% CI -0.86 to -0.13; p < 0.01) compared with conventional clinical therapy. Most in-dices did not support the use of tai chi over aerobic exercise, except for glycated haemoglobin (HbA1c) (MD = -0.24; 95% CI -0.49 to 0.00; p < 0.01) and high-density lipoprotein (MD = 0.07; 95% CI 0.01 to 0.12; p < 0.01). CONCLUSION: Tai chi had better effects on metabolic control and body composition indicators than clinical conventional therapy, but only on HbA1c and HDL were superior than that of aerobic exercise. The best time-window for tai chi intervention may differ with different metabolic indices.


Assuntos
Composição Corporal/fisiologia , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/terapia , Controle Glicêmico/métodos , Metabolismo dos Lipídeos/fisiologia , Tai Ji/métodos , Adulto , Humanos
14.
Acta Diabetol ; 58(6): 671-685, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33417039

RESUMO

AIMS: Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies. METHODS: We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16. RESULTS: A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I2=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I2=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I2=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I2=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I2=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I2=91.2%). CONCLUSION: Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.


Assuntos
Disfunção Cognitiva/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/epidemiologia , Doença de Alzheimer/etiologia , Ásia/epidemiologia , China/epidemiologia , Disfunção Cognitiva/etiologia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/psicologia , Europa (Continente)/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco
15.
Ying Yong Sheng Tai Xue Bao ; 31(9): 3093-3100, 2020 Sep 15.
Artigo em Chinês | MEDLINE | ID: mdl-33345511

RESUMO

We investigated the effects of dicyandiamide (DCD) on the growth and Cd concentrations in pakchoi cultivated under different instant soluble N fertilizers [ammonium sulfate, ammonium sulfate and sodium nitrate (1:1, ammonium/nitrate), and urea] in Cd-contaminated soils. The results showed that the fresh weight of the edible parts of Cd-stressed pakchoi were increased by 583.3%, 41.5%, and 206.8% under ammonium, ammonium/nitrate, and urea treatments in the presence of DCD, respectively compared with control, and the tolerance index and photosynthetic rate significantly increased, whereas no significant changes were observed under nitrate supply. Under all N treatments with DCD, the MDA and H2O2 contents and the superoxide radical production rate in the leaves of pakchoi were decreased, with the highest reduction occurred in ammonium and urea treatments. Cd concentrations in the leaves of pakchoi fertilized with ammonium, ammonium/nitrate, and urea were lowered by 58.3%, 34.0%, and 44.5% and those in the petioles were lowered by 61.8%, 29.4%, and 55.6%, respectively. Cd concentration in the leaves and petioles of pakchoi in the nitrate treatment did not differ significantly from control. These changes could be attributable to the reduction in the acidification of rhizosphere soil in response to the combined application of N fertilizer and DCD. Accordingly, in Cd-contaminated soils with a low buffering capacity, the application of DCD combined with ammonium, ammonium/nitrate, or urea N fertili-zers could alleviate Cd-induced growth stress and inhibit photosynthesis in pakchoi plants and effectively minimize the Cd accumulation.


Assuntos
Fertilizantes , Poluentes do Solo , Cádmio/análise , Fertilizantes/análise , Guanidinas , Peróxido de Hidrogênio , Nitrogênio , Solo , Poluentes do Solo/análise
16.
Proc Natl Acad Sci U S A ; 117(47): 29569-29576, 2020 11 24.
Artigo em Inglês | MEDLINE | ID: mdl-33139545

RESUMO

Horseback riding was a transformative force in the ancient world, prompting radical shifts in human mobility, warfare, trade, and interaction. In China, domestic horses laid the foundation for trade, communication, and state infrastructure along the ancient Silk Road, while also stimulating key military, social, and political changes in Chinese society. Nonetheless, the emergence and adoption of mounted horseback riding in China is still poorly understood, particularly due to a lack of direct archaeological data. Here we present a detailed osteological study of eight horse skeletons dated to ca. 350 BCE from the sites of Shirenzigou and Xigou in Xinjiang, northwest China, prior to the formalization of Silk Road trade across this key region. Our analyses reveal characteristic osteological changes associated with equestrian practices on all specimens. Alongside other relevant archaeological evidence, these data provide direct evidence for mounted horseback riding, horse equipment, and mounted archery in northwest China by the late first millennium BCE. Most importantly, our results suggest that this region may have played a crucial role in the spread of equestrian technologies from the Eurasian interior to the settled civilizations of early China, where horses facilitated the rise of the first united Chinese empires and the emergence of transcontinental trade networks.


Assuntos
Cavalos/fisiologia , Esportes/fisiologia , Animais , Arqueologia/métodos , China , Esqueleto/fisiologia
17.
Proc Natl Acad Sci U S A ; 117(44): 27549-27555, 2020 11 03.
Artigo em Inglês | MEDLINE | ID: mdl-33077583

RESUMO

Global food security is a major driver of population health, and food system collapse may have complex and long-lasting effects on health outcomes. We examined the effect of prenatal exposure to the Great Chinese Famine (1958-1962)-the largest famine in human history-on pulmonary tuberculosis (PTB) across consecutive generations in a major center of ongoing transmission in China. We analyzed >1 million PTB cases diagnosed between 2005 and 2018 in Sichuan Province using age-period-cohort analysis and mixed-effects metaregression to estimate the effect of the famine on PTB risk in the directly affected birth cohort (F1) and their likely offspring (F2). The analysis was repeated on certain sexually transmitted and blood-borne infections (STBBI) to explore potential mechanisms of the intergenerational effects. A substantial burden of active PTB in the exposed F1 cohort and their offspring was attributable to the Great Chinese Famine, with more than 12,000 famine-attributable active PTB cases (>1.23% of all cases reported between 2005 and 2018). An interquartile range increase in famine intensity resulted in a 6.53% (95% confidence interval [CI]: 1.19-12.14%) increase in the ratio of observed to expected incidence rate (incidence rate ratio, IRR) in the absence of famine in F1, and an 8.32% (95% CI: 0.59-16.6%) increase in F2 IRR. Increased risk of STBBI was also observed in F2. Prenatal and early-life exposure to malnutrition may increase the risk of active PTB in the exposed generation and their offspring, with the intergenerational effect potentially due to both within-household transmission and increases in host susceptibility.


Assuntos
Fome Epidêmica , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Inanição/complicações , Tuberculose Pulmonar/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/imunologia , Gravidez , Efeitos Tardios da Exposição Pré-Natal/imunologia , Efeitos Tardios da Exposição Pré-Natal/prevenção & controle , Fatores de Risco , Inanição/imunologia , Vacinas contra a Tuberculose/administração & dosagem , Vacinas contra a Tuberculose/imunologia , Tuberculose Pulmonar/imunologia , Tuberculose Pulmonar/prevenção & controle , Adulto Jovem
18.
Bioresour Technol ; 318: 124094, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32932116

RESUMO

The long-term effect of fulvic acid (FA) on bioreactor performance and on microbial populations within the anammox process were firstly investigated in this study. The average nitrogen removal rate showed an upward trend when the influent TOC concentration of FA was 25.2-65.1 mg/L. However, when FA was increased to 80.3 mg/L, the reactor performance was slightly inhibited. In addition, judging from the particle size and settling properties, FA can promote anammox sludge granulation. After 53 days of exposure to FA, the genus Anaerolineaincreased in number, while Denitratisoma decreased. Candidatus Jettenia and Candidatus Kuenenia survived and enriched in the changed environment, potentially due to the interaction between anammox bacteria and some heterotrophic bacteria, which could protect anammox bacteria from adverse environments. These results indicate that FA can change the bacterial community and trigger different microbial interaction mechanisms within the anammox reactor.


Assuntos
Compostos de Amônio , Anaerobiose , Benzopiranos , Reatores Biológicos , Nitrogênio , Oxirredução , Esgotos , Águas Residuárias
19.
Int J Biol Macromol ; 162: 310-319, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32569682

RESUMO

CuS/ZnS/sodium alginate/reduced graphene oxide nanocomposites (CZSrG) were prepared by physical crosslinking followed by one-step reduction and were justified as green binder-free hydrogel high-capacitance electrodes. The physical crosslinking was realized simply through the hydrogen-bond interaction between sodium alginate (SA) and graphene oxide (GO), avoiding the usage of traditional Ca2+ crosslinking agent. The hydrogel structure made of CZSrG possessed the most beneficial effect of avoiding large volume change and increasing cycle stability for supercapacitors. When used as electrode, the specific capacitance of CZSrG was 992 F·g-1 (10 mV·s-1) in a three-electrode system. Furthermore, the fabricated supercapacitors had a specific capacitance of 252.1 F·g-1 (5 mV·s-1), and a power density of 1800 Wh·kg-1 at the energy density of 2.05 Wh·kg-1. Thus, the CZSrG has a favorable electrochemical performance and wide application prospects in supercapacitors.


Assuntos
Alginatos/química , Cobre/química , Capacitância Elétrica , Eletroquímica/métodos , Grafite/química , Nanogéis/química , Sulfetos/química , Compostos de Zinco/química , Reagentes para Ligações Cruzadas/química , Eletroquímica/instrumentação , Eletrodos , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Nanocompostos/química , Nanocompostos/ultraestrutura , Nanogéis/ultraestrutura , Sulfetos/síntese química , Compostos de Zinco/síntese química
20.
Photobiomodul Photomed Laser Surg ; 38(7): 444-451, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32357083

RESUMO

Background and objective: Intense pulsed light (IPL) improves visual and clinical symptoms of dry eye disease and helps improve meibomian gland (MG) function thereby positively contributing to the tear lipid layer, a major component for a normal tear film physiology. The objective of this study was to assess the effectiveness of IPL in moderate to severe evaporative dry eye (DE) owing to meibomian gland dysfunction (MGD) on the subjective quality of vision (QOV). Methods: This is a prospective, open-label study; patients with moderate to severe evaporative DE owing to MGD were consecutively enrolled and underwent two IPL treatment sessions at 3-week intervals. Clinical assessments included: Ocular Surface Disease Index (OSDI) and QOV questionnaires, noninvasive tear breakup time (NITBUT), interferometric fringe pattern as determined by tear film lipid layer (TFLL) quality, lid margin abnormalities, corneal fluorescein staining (CFS), conjunctival hyperemia (CH) redness score, MG (evaluated with a slit-lamp microscope), best-corrected visual acuity, endothelial cell count, and intraocular pressure were conducted at pretreatment, days 21 and 42 after IPL treatment. Results: A total of 128 eyes of 64 patients (39 women, 25 men; mean age 36.09 ± 11.13 years) with moderate to severe DE owing to MGD consecutively received IPL treatment at days 1 and 21. OSDI (p < 0.05), QOV (p < 0.05), NITBUT (p < 0.05), TFLL score (p < 0.05), and MG quality and expressibility (p < 0.05) improved significantly at day 42, whereas CFS and CH showed minor not significant improvements (p > 0.05) at day 42 of assessment. Conclusions: IPL treatment reduced the severity of DE symptoms and improved the overall tear film stability in patients with moderate to severe evaporative DE owing to MGD. In addition, visual complaints experienced by DE patients secondary to MGD significantly decreased.

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