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1.
Cell Biol Int ; 46(3): 336-343, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34941001

RESUMO

Osteosarcoma is a malignant tumor that often occurs in adolescents. There is an urgent need for new treatment options for osteosarcoma due to its poor prognosis after metastasis. Cancer stem cell (CSC) theory states that CSCs represent a small proportion of cancer cells. These CSC have self-renewal ability and are closely associated with cancer growth and metastasis as well as chemotherapy resistance. Similarly, osteosarcoma stem cells (OSCs) play an important role in the growth, metastasis, and chemotherapy resistance of osteosarcoma cells. Targeting OSCs may represent a future treatment of osteosarcoma. Furthermore, some genes have been shown to regulate the growth, metastasis, and chemotherapy resistance of osteosarcoma cells by altering the stemness of OSCs. Targeting these genes may help in the treatment of osteosarcoma. This review mainly discusses recent advances in the research of OSCs and their related genes.


Assuntos
Neoplasias Ósseas , Osteossarcoma , Adolescente , Neoplasias Ósseas/patologia , Linhagem Celular Tumoral , Proliferação de Células , Humanos , Células-Tronco Neoplásicas/patologia , Osteossarcoma/patologia
2.
Asian J Androl ; 2022 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-35546286

RESUMO

This study aims to characterize the cell atlas of the epididymis derived from a 46,XY disorders of sex development (DSD) patient with a novel heterozygous mutation of the nuclear receptor subfamily 5 group A member 1 (NR5A1) gene. Next-generation sequencing found a heterozygous c.124C>G mutation in NR5A1 that resulted in a p.Q42E missense mutation in the conserved DNA-binding domain of NR5A1. The patient demonstrated feminization of external genitalia and Tanner stage 1 breast development. The surgical procedure revealed a morphologically normal epididymis and vas deferens but a dysplastic testis. Microfluidic-based single-cell RNA sequencing (scRNA-seq) analysis found that the fibroblast cells were significantly increased (approximately 46.5%), whereas the number of main epididymal epithelial cells (approximately 9.2%), such as principal cells and basal cells, was dramatically decreased. Bioinformatics analysis of cell-cell communications and gene regulatory networks at the single-cell level inferred that epididymal epithelial cell loss and fibroblast occupation are associated with the epithelial-to-mesenchymal transition (EMT) process. The present study provides a cell atlas of the epididymis of a patient with 46,XY DSD and serves as an important resource for understanding the pathophysiology of DSD.

3.
Front Microbiol ; 13: 884034, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35572668

RESUMO

Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), public health worldwide has been greatly threatened. The development of an effective treatment for this infection is crucial and urgent but is hampered by the incomplete understanding of the viral infection mechanisms and the lack of specific antiviral agents. We previously reported that teicoplanin, a glycopeptide antibiotic that has been commonly used in the clinic to treat bacterial infection, significantly restrained the cell entry of Ebola virus, SARS-CoV, and MERS-CoV by specifically inhibiting the activity of cathepsin L (CTSL). Here, we found that the cleavage sites of CTSL on the spike proteins of SARS-CoV-2 were highly conserved among all the variants. The treatment with teicoplanin suppressed the proteolytic activity of CTSL on spike and prevented the cellular infection of different pseudotyped SARS-CoV-2 viruses. Teicoplanin potently prevented the entry of SARS-CoV-2 into the cellular cytoplasm with an IC50 of 2.038 µM for the Wuhan-Hu-1 reference strain and an IC50 of 2.116 µM for the SARS-CoV-2 (D614G) variant. The pre-treatment of teicoplanin also prevented SARS-CoV-2 infection in hACE2 mice. In summary, our data reveal that CTSL is required for both SARS-CoV-2 and SARS-CoV infection and demonstrate the therapeutic potential of teicoplanin for universal anti-CoVs intervention.

4.
Front Oncol ; 12: 878513, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35530358

RESUMO

Objectives: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and characterized by high aggressiveness and extremely poor prognosis. Increasing evidence has suggested that circular RNAs (circRNAs), which are highly stable, play crucial roles in the progression of multiple malignancies. However, the roles of circRNAs in HCC remain elusive. Materials and Methods: The expression patterns of circRNAs in HCC were identified by qRT-PCR. A series of functional experiments both in vivo and in vitro were used to determine the role of circERBIN in HCC proliferation. Bioinformatics and an RNA pulldown assay were used to identify potential downstream targets of circERBIN. Results: The expression of circERBIN was upregulated in HCC cell lines and tissues, which was predictive of a poor prognosis in HCC patients. Elevated circERBIN promoted G1/S transition of HCC cells, thus facilitating the proliferation and tumorigenesis of HCC cells. Mechanistic investigations revealed that circERBIN regulated HCC proliferation by acting as a sponge of miR-1263, which subsequently targeted cyclin dependent kinase 6 and controlled G1/S transition. Conclusion: Taken together, these results determined that circERBIN functions as an important epigenetic regulator in HCC development, highlighting that circERBIN is a promising target for treatment of HCC.

5.
JAMA Ophthalmol ; 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35511131

RESUMO

Importance: The association between availability of eye care clinicians and visual impairment, a condition presenting with increased morbidity and health care costs, has not been thoroughly studied. Objective: To examine associations between the geographic distribution of eye care clinicians and visual impairment in California. Design, Setting, and Participants: This survey-based cross-sectional study included ophthalmologists and optometrists licensed in California in 2018 and 2020 as well as respondents to the 2014 to 2018 American Community Survey (ACS) by California counties and Medical Service Study Areas (MSSAs). Data were analyzed from August 2020 to December 2021. Main Outcomes and Measures: Prevalence of visual impairment by county and MSSA. Exposures: The number of eye care clinicians was determined based on the number of member ophthalmologists of the American Academy of Ophthalmology in 2018 and optometrists listed in the 2020 Blue Book of Optometrists in California. The prevalence of visual impairment was determined using questionnaire data from the American Community Survey. Linear regression was used to assess multivariable associations between number of eye care clinicians and visual impairment by MSSA. Results: A total of 30 068 581 California residents were included; 15 253 655 (50.7%) were female, and 5 314 389 (17.7%) were 65 years and older. The overall number of eye care clinicians was 22.18 clinicians per 100 000 residents. The overall prevalence of visual impairment was 2411.07 residents with visual impairment per 100 000 residents. San Francisco County had the highest number of eye care clinicians per 100 000 residents (39.24 clinicians per 100 000 residents). Four counties had no eye care clinicians (Alpine, Mariposa, Inyo, and Sierra counties). For every increase of 1 eye care clinician per 100 000 residents, there was a mean (SE) decrease of 3.90 (1.39) persons with visual impairment per 100 000 residents in adjusted analyses. Conclusions and Relevance: In this cross-sectional study, a higher number of eye care clinicians was potentially associated with lower prevalence of visual impairment in California. Additional studies are needed to assess eye care clinician availability on a national and global scale and strategies to improve access to eye care.

6.
Int J Surg ; : 106676, 2022 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-35577311

RESUMO

BACKGROUND: Laparoscopic radical antegrade modular pancreatosplenectomy (l-RAMPS) provides a new surgical approach for patients with pancreatic cancers of the body and tail. However, whether it can achieve comparable outcomes to the open RAMPS (o-RAMPS) remains an issue. METHODS: To evaluate the safety and effectiveness of l-RAMPS, the studies in the databases of Medline, Embase, and the Cochrane Library published before 13 September 2021 were searched and a meta-analysis was performed using the 2020 Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline. The perioperative and oncological outcomes were analyzed. RESULTS: Five retrospective cohorts involving 189 patients were included for final pooled analysis. There were no significant differences in the patients' operation time, intra-abdominal bleeding rate, intra-abdominal infection rate, mild morbidity (Clavien-Dindo classification = 1), moderate to severe morbidity (Clavien-Dindo classification ≥2), overall morbidity, wound infection rate, pancreatic fistula rate, delayed gastric emptying rate, reoperation rate, length of hospital stay, postoperative mortality, R0 resection rate, and 2-year overall survival between the 2 approaches. Besides, l-RAMPS was associated with less blood loss (mean difference (MD) = -232.69, 95% confidence interval (CI) = -316.93 to -148.46, P < 0.00001) and shorter days until oral feeding (MD = -0.79, 95% CI = -1.35 to -0.22, P = 0.006). However, the pooled analysis also indicated a significantly fewer lymph nodes dissected (MD = -3.01, 95% CI = -5.59 to -0.43, P = 0.02) in l-RAMPS approach. CONCLUSIONS: Although l-RAMPS provides similar outcomes associated with benefits of minimal invasiveness compared to o-RAMPS, it harvested significantly fewer lymph nodes which might have potentially negative influence on the patients' long-term survival. L-RAMPS is still in the infancy stage and further investigation is needed to verify its feasibility.

7.
Plant Cell ; 2022 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-35579372

RESUMO

The MAP215 family of microtubule (MT) polymerase/nucleation factors and the MT severing enzyme katanin are widely conserved microtubule-associated proteins (MAPs) across the plant and animal kingdoms. However, how these two essential MAPs coordinate to regulate plant MT dynamics and development remains unknown. Here, we identified novel hypomorphic alleles of MICROTUBULE ORGANIZATION 1 (MOR1), encoding the Arabidopsis thaliana homolog of MAP215, in genetic screens for mutants oversensitive to the MT-destabilizing drug propyzamide. Live imaging in planta revealed that MOR1-green fluorescent protein (GFP) predominantly tracks the plus-ends of cortical MTs in interphase cells and labels preprophase band, spindle and phragmoplast MT arrays in diving cells. Remarkably, MOR1 and KATANIN 1 (KTN1), the p60 subunit of Arabidopsis katanin, act synergistically to control the proper formation of plant-specific MT arrays, and consequently, cell division and anisotropic cell expansion. Moreover, MOR1 physically interacts with KTN1 and promotes KTN1-mediated severing of cortical MTs. Our work establishes the Arabidopsis MOR1-KTN1 interaction as a central functional node dictating MT dynamics and plant growth and development.

8.
Virus Res ; 315: 198794, 2022 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-35504448

RESUMO

Channel catfish virus (CCV), an important member of the family Alloherpesviridae, causes a lethal infection in channel catfish. As with most animal viruses, the initial step of infection by CCV is entry into host cells, which is also a promising antiviral target for CCV disease. This study investigated the mechanism of host cell invasion by CCV using a series of biochemical inhibitor assays in channel catfish cells. CCV infection in host cells was does-dependently inhibited when cells were treated with endosomal acidification inhibitors (5 µM chloroquine, 50 nM bafilomycin A1, and 1 mM ammonium chloride) and hypertonic medium (50 mM sucrose) , which suggests that CCV invades host cells in a manner dependent on low-pH and the endocytic pathway. Moreover, when the cells were pretreated with inhibitors of clathrin-mediated endocytosis, including chlorpromazine (2 µM) and dynasore (50 µM), the CCV infection in the host cells was strongly inhibited. In contrast, the destruction of cellular cholesterol by methyl-ß-cyclodextrin and nystatin and inhibition of macropinocytosis had no effect on viral entry. Altogether, these findings indicate that CCV infects host cells via clathrin-mediated endocytosis in a low-pH-dependent manner, suggesting that this CCV entry pathway offers an antiviral target against CCV disease.

9.
Artigo em Inglês | MEDLINE | ID: mdl-35510903

RESUMO

Polyoxometalates (POMs) have shown great potential in sodium-ion batteries (SIBs) due to their reversible multielectron redox property and high ionic conductivity. Currently, POM-based SIBs suffer from the irreversible trapping and sluggish transmission kinetics of Na+. Herein, a series of POMs/metal-organic frameworks (MOFs)/graphene oxide (GO) (MOFs = MIL-101, MIL-53, and MIL-88B; POM = [PMo12O40]3-, denoted as PMo12) composites are developed as SIB anode materials for the first time. Unlike MIL-101 with large pore structures, the pores in flexible MIL-53 and MIL-88B swell spontaneously upon the accommodation of PMo12. Particularly, the PMo12/MIL-88B/GO composites deliver an excellent specific capacity of 214.2 mAh g-1 for 600 cycles at 2.0 A g-1, with a high initial Coulombic efficiency (ICE) of 51.0%. The so-called "breathing effect" of flexible MOFs leads to the relatively tight confinement space for PMo12, which greatly modulates its electronic structure, affects the adsorption energy of Na+, and eventually reduces the trapping of sodium ions. Additionally, the straight and multidimensional channels in MIL-88B significantly accelerate ion diffusion, inducing favored energetic kinetics and thus generating high-rate performance.

10.
J Org Chem ; 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35512323

RESUMO

Liriogerphines A-D (1-4, respectively), an unprecedented class of hybrids of germacranolide-type sesquiterpenoids and aporphine-type alkaloids, were isolated from the rare medicinal plant Liriodendron chinense. Their structures were elucidated by comprehensive spectroscopic analyses combined with electronic circular dichroism calculations and X-ray crystallographic data. Biosynthetically, an aza-Michael addition reaction is proposed to be involved in the assemblies of this class of hybrids. Compound 4 exhibited cytotoxicity against leukemia cells via inducing apoptosis and inhibiting Bcl-2 expression.

11.
Artigo em Inglês | MEDLINE | ID: mdl-35536010

RESUMO

While flexible supercapacitors with high capacitance and energy density is highly desired for outdoor wearable electronics, their application under low-temperature environments, like other energy storage devices, remains an urgent challenge. Solar thermal energy converts solar light into heat and has been extensively applied for solar desalination and power generation. In the present work, to address the failure problem of energy storage devices in a cold environment, solar thermal energy was used to improve flexible supercapacitor performance at low temperature. As a proof of concept presented here, a typical all-solid-state supercapacitor composed of activated carbon electrodes and gel polymer electrolyte was coated by a carbonized melamine sponge. Due to the ability of photothermal conversion of carbonized melamine sponge, the capacitance of the supercapacitor was greatly enhanced, which could be further improved by adding surface plasmonic nanomaterials, for example, Ag nanowires. Compared with the device without photothermal conversion layers, the specific capacitance increased 3.48 times at -20 °C and retained 87% capacitance at room temperature and the specific capacitance increased 6.69 times at -50 °C and retained 73% capacitance at room temperature. The present work may provide new insights on the application of solar energy and the design of energy storage devices with excellent low-temperature resistance.

12.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 44(2): 221-226, 2022 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-35538756

RESUMO

Objective To investigate the rate and correlates of receiving human immunodeficiency virus(HIV) serostatus disclosure from their most recent male sexual partners among men who have sex with men(MSM) aged 50 and above. Methods With a geosocial networking application,we recruited participants through online convenience sampling to collect the demographic variables,behavioral information,receiving HIV serostatus disclosure,etc.Univariate and multivariate analyses were performed to interpret the associated factors of receiving HIV serostatus disclosure. Results Overall,38.4%(398/1037) of participants received HIV serostatus disclosure from their most recent male sexual partners.The multivariable analysis demonstrated that the following populations were less likely to receive HIV serostatus disclosure from their most recent male sexual partners:participants with junior high school degree or below(OR=0.660,95%CI=0.473-0.922, P=0.015) compared to those with senior high school degree or above;participants unemployed(OR=0.537,95%CI=0.322-0.896, P=0.017) and employed(OR=0.663,95%CI=0.466-0.944, P=0.022) compared to those retired;participants without knowledge about HIV or acquired immune deficiency syndrome(AIDS) compared to those with knowledge about HIV/AIDS(OR=0.636,95%CI=0.466-0.868, P=0.004);participants having ≥2 male sexual partners in the last year(OR=0.433,95%CI=0.320-0.586, P<0.001) compared to those having none or one male sexual partner;participants never been tested for HIV(OR=0.544,95%CI=0.403-0.734, P<0.001) compared to those ever been tested for HIV;participants ever been diagnosed to have sexually transmitted infection(STI)(OR=0.472,95%CI=0.349-0.637, P<0.001) compared to those never diagnosed to have STI;and participants with higher level of HIV stigma(OR=0.742,95%CI=0.604-0.912, P=0.005). Conclusions Our findings indicated that the MSM aged 50 and above had low possibility of receiving HIV serostatus disclosure from the most recent male sexual partners.Education,employment status,number of sexual partners,HIV/AIDS-related knowledge,HIV testing behaviors,STI infection history,and HIV stigma contributed to this result.

13.
Sci Total Environ ; 837: 155662, 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35525355

RESUMO

The treatment of antibiotic wastewater pollution is imminent, the studies of double-network hydrogels as adsorbents have gradually increased, it is quite important to develop a non-toxic hydrogel with excellent properties as adsorbent. In this study, a graphene oxide modified κ-carrageenan/sodium alginate (GO-κ-car/SA) gel was prepared by calcium hardening. The addition of GO nanosheets enhances the mechanical strength and anti-swelling property of the double-network hydrogel, making it possible for the application in the fixed-bed column system. The elastic modulus is twice as much as the hydrogel without GO. The maximum adsorption capacity in the experiments of the GO-κ-car/SA gel for CIP and OFL can reach 272.18 mg g-1 and 197.39 mg g-1, respectively. The GO-κ-car/SA gel always remains negatively charged, which means that the adsorption capacity of the gel is better in an acidic environment. In the fixed-bed column system, through Thomas fitting, the maximum adsorption capacity of the simulated OFL wastewater (200 mg L-1) is 83.99 mg g-1. The adsorption mechanism of antibiotics by GO-κ-car/SA gel depends on hydrogen bond, functional groups and electrostatic adsorption. The good hydrophilic properties, excellent adsorption capacity and high mechanical strength, which can ensure that the adsorbent is in full contact with the contaminants without major deformation or damage, makes the study more helpful for the further study on hydrogel in the fixed-bed column system.

14.
Front Nutr ; 9: 806887, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35495921

RESUMO

Background: In this study, we enrolled 862 patients with Crohn's disease (CD) in China to investigate the correlation between serum vitamin D (SVD) and serum lipids, inflammatory biomarkers, and important clinical parameters. Materials and Methods: 25(OH)D was measured by LS/MS/MS. Correlation analysis, chi-square tests, and logistic regression analysis were performed to determine the correlations between vitamin D and potential risk factors when vitamin D levels were lower than 10 ng/mL or 20 ng/mL. Results: The incidence of severe vitamin D deficiency (SVD < 10 ng/mL) in patients with CD was significantly higher than that in healthy controls (28.9 vs. 9.5%). Multinomial logistic regression analysis showed that penetrating disease [odds ratio (OR) = 2.18], low levels of high-density lipoprotein cholesterol (HDL) (OR = 1.91), high erythrocyte sedimentation rate (OR = 1.73), and platelet count (PLT) (OR = 2.71) were regarded as predictors of severe vitamin D deficiency, while only PLT (OR = 1.90) and HDL (OR = 1.76) were considered as predictors of mild vitamin D deficiency (SVD 10-20 ng/mL). Conclusion: Our results confirm a higher incidence of severe vitamin D deficiency in patients with CD in China and show that vitamin D deficiency could result from the combined effects of penetrating disease, inflammation, and low levels of HDL.

15.
ChemSusChem ; 2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-35502630

RESUMO

Highly selective conversion of methane to oxygenates with O 2 as a green oxidant remains a great challenge. It is still difficult to suppress the generation of CO x (x=1, 2) as undesired by-products due to unavoidable overoxidation reaction. Hence, tungsten-doped (W-doped) TiO 2 photocatalysts were designed with a tunable band structure for photocatalytic oxidation of methane to C1 oxygenates using O 2 at low temperature (30 °C). The W-doping effectively modified the electronic and band structure of pristine TiO 2 to enhance photocatalytic performance. Liquid oxygenates productivity can reach as high as 12.2 mmol/g with high selectivity of 99.4%. Moreover, CO x selectivity was effectively decreased from 21.2% over TiO 2 to 0.6% for W-doped catalyst. Detailed characterizations further disclosed that W-doping not only enhanced light absorption, but also promoted the separation of photo-generated carriers to improve methane conversion. This work provides new insights into the design of highly efficient photocatalysts for methane oxidation.

16.
Chin J Integr Med ; 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35508862

RESUMO

OBJECTIVE: To evaluate the effect and safety of low-dose of apatinib and S-1 combined with Jianpi Bushen Jiedu Decoction (JBJD) in patients with metastatic colorectal cancer (mCRC) who have failed second or above lines treatment, in order to provide more treatment option for mCRC patients by integrated medicine. METHODS: Thirteen patients were selected from a single-arm, open-label clinical study from April 2019 to September 2020. The patients were treated with low-dose apatinib (250 mg, once a day) and S-1 (20 mg, twice a day) combined with JBJD for at least one cycle and were followed up to August 2021. The primary endpoint was disease progression-free survival (PFS). Disease control rate (DCR), objective response rate (ORR), and overall survival (OS) of patients were observed as the secondary endpoints. Adverse events were recorded as well. RESULTS: The average age of the 13 patients was 56.5 ±13.0 years and 76.9% were male. The median PFS and median OS were 4.6 and 8.3 months, respectively. The ORR was 7.7% (1/13) while the DCR was 61.5% (8/13). The common adverse events were hypertension, proteinuria, elevated transaminase, and thrombocytopenia. One patient experienced thrombocytopenia of grade 3. CONCLUSIONS: Patients with mCRC after failure of the second or above lines of treatment may potentially benefit from the treatment of low-dose apatinib and S-1 combined with JBJD because of its similar effect as the standard dose of target therapy and relatively better safety. (Registration No. ChiCTR1900022673).

17.
Front Public Health ; 10: 825106, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35419338

RESUMO

Relatively low level of safety culture among undergraduates and the imperfection of safety management system for students in university result in numerous safety problems. Researches on the safety culture of undergraduates in public universities are much more than those in private universities. Aiming to find out the potential and specific factors that affect the safety culture in the former are different from those in the latter, an anonymous questionnaire survey was conducted among 4,531 students in a private university in Shaanxi province, China. Gender, education background, grade, hometown, one-child policy, major, community, and driver's license on their safety beliefs and behaviors are treated as potential factors in the survey. According to the average score of each item, the investigated private university students are lack of safety knowledge, but perform well in traffic safety behavior. The results show that female students show better safety beliefs and safety behaviors than male students whilst the safety beliefs and safety behaviors of the student majoring in medicine is better than those of students in other majors. The students who live in more developed cities, who are from one-child family and who have driving license, show better safety beliefs and safety behaviors than others. The effective community system of mixed majors is conducive to the formation of good safety beliefs and safety behaviors of college students. The results highlighted that universities should formulate the corresponding intervention strategies to prevent safety problems of the college students according to the specific proportion of gender, major distribution and other actual situation.


Assuntos
Gestão da Segurança , Estudantes , China , Feminino , Humanos , Masculino , Inquéritos e Questionários , Universidades
18.
Front Oncol ; 12: 835956, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35402274

RESUMO

Purpose: There is increasing evidence for convincing efficacy and safety of 177Lu-labled prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT) for metastatic castration-resistant prostate cancer (mCRPC). However, data are not available regarding the feasibility of 177Lu-labled PSMA-targeted RLT in East Asians. The present study summarized the first experience with 177Lu-PSMA-I&T therapy for mCRPC in China. Methods: Forty consecutive patients with mCRPC were enrolled from December 2019 to September 2021. Eligible patients received 177Lu-PSMA-I&T RLT at intervals of 8-12 weeks. Toxicity was assessed based on standardized physicians' reports and the Common Toxicity Criteria for Adverse Events criteria. Response to PRLT was evaluated according to the changes of prostate specific antigen (PSA) response and imaging response. Quality of life (QOL), Karnofsky performance status (KPS) and pain (visual analogue scale, VAS) were also evaluated. The impacts of baseline parameters on the therapeutic effects were explored by univariate and multivariate logistic regression analyses. Results: All patients underwent a total of 86 cycles of 177Lu-PSMA-I&T (range: 1-5 cycles) with dosages of 3.70-14.43GBq per cycle, with a median of 8 months followed up. Six patients (15%) developed mild reversible xerostomia during follow-up, and 28 patients (70%) experienced grade 1-4 bone marrow dysfunction. Changes in PSA were assessed after therapy, accompanied by the partial response (PR) in 25 patients (62.5%), the stable disease (SD) in 5 patients (12.5%), and the progressive disease (PD) in 10 patients (25%), respectively. QOL, KPS (%) and VAS scores were improved significantly due to treatment (P<0.05). Overweight and elevated AST, ALP, and LDH were associated with poor outcomes. Conclusions: 177Lu-PSMA-I&T achieves the favourable response and well tolerance in mCRPC, which associates with not only PSA decline but also with tumor remission including lymphadenopathy and bone metastasis. We also find that patients with overweight and high AST, ALP, and LDH should be cautious to undergo the PRLT. Large-cohort studies are warranted to confirm the initial findings and elucidate the survival benefit of the treatment.

19.
Eur Phys J Plus ; 137(4): 434, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35411291

RESUMO

Memristor is widely used in various neural bionic models because of its excellent characteristics in biological neural activity simulation. In this paper, a piecewise nonlinear function is used to transform the quartic memristor, which is introduced into the ternary Hopfield neural network (HNN) with self-feedback, and a piecewise quartic memristive chaotic neural network model with multi-scroll is constructed. Through simulation analysis, the number of scroll layers changes with memristor parameters and has significant coexistence of multi-scroll attractors and high initial value sensitivity has been found. Using its excellent unpredictability, a digital watermarking algorithm based on wavelet transform is improved and used in the protection of personal medical data. The results show that it not only improves the confidentiality and convenience, but also ensures its robustness and has good encryption effect.

20.
Front Pediatr ; 10: 799307, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35391745

RESUMO

Purpose: Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis. Methods: The clinical data from children with high-risk HB or HB tumor rupture at our institution from October 2008 to 2017 were retrospectively reviewed and analyzed. Results: Together, 34 children with high-risk HB or HB tumor rupture were retrospected, including 25 in the high-risk group and nine in tumor rupture group. The 3-year overall survival (OS) rate in tumor rupture group was significantly higher than that of the high-risk group (100 vs. 64%, p = 0.0427). In tumor rupture group, seven (77.8%) of nine patients had a hemoglobin level ≤ 8 g/L and 3 of them (33.3%) had ≤ 6 g/L at the time of diagnosis. Peritoneal perfusion with interleukin-2 was implemented for each patient. At the end of the treatment, seven (77.8%) of nine patients achieved complete response (CR). No patient died at the last follow-up. Conclusions: HB tumor rupture might not be predictive of poor prognosis with the risk of peritoneal dissemination/relapse, in which peritoneal perfusion with interleukin-2 could play a role.

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