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Artigo em Chinês | MEDLINE | ID: mdl-30317807


Objective: To explore the turnover intention of nurses in Quzhou and its influential factors. Methods: From July to August in 2017 cross-sectional study and self-filled questionnaire are used to investigate 980 nurses from 7 hospitals in Quzhou, including two third-level hospitals and five second-level ones. T-test, F-test, Pearson and linear regression are used in data with the method of statistical analysis. Results: The total score of turnover intention of nurses was (14.95±3.17) points, and the index value was 62.27%, of which the turnover intention was above 78%. The analysis of Single factor showed that age (F=4.895) , Department (F=2.971) , title, nursing age (F=5.863) , self-assessment of physical conditions (F=4.092) were closely related to nurses' turnover intention(P<0.05). According to Person's correlation analysis, there are positive correlations between turnover intention and source of stressor, and moral distress (P<0.05) . Multiple linear regression showed that the nurses' turnover intention was age, Department, health selfevaluation, stressor and moral distress. Conclusion: The turnover intention of nurses is high, which is related to age, Department, self-evaluation of health, stressor and moral distress.

Intenção , Princípios Morais , Recursos Humanos de Enfermagem no Hospital/psicologia , Reorganização de Recursos Humanos , Estresse Psicológico , Estudos Transversais , Humanos , Recursos Humanos de Enfermagem no Hospital/estatística & dados numéricos , Fatores de Risco , Inquéritos e Questionários
SAR QSAR Environ Res ; 18(5-6): 603-19, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17654340


Density functional theory (DFT) at B3LYP/6-311G** level was employed to optimise the dioxin compounds, i.e., 25 polychlorinated or brominated dibenzo-p-dioxins (PCDDs or PBDDs) and 34 polychlorinated dibenzofurans (PCDFs) involved in this investigation. Three groups of descriptors mainly related to chemical reactivity, molecular overall charge distribution and thermochemical property were calculated. With partial least squares (PLS) analysis and variable importance in the projection (VIP), the least significant descriptors were removed from the quantitative structure-activity relationship (QSAR), which was focused on exploring the influential factors responsible for the variance of binding affinities of dioxins to aryl hydrocarbon receptor (AhR). With better-improved and predictive QSAR (Q(2)(cum) = 0.827), further understanding of the nature of toxicity was available. Both dispersion interaction and electrostatic interaction were considered to be important and together capable of accounting for the most part of the total binding affinities, though the former could make more contribution than the latter. Comparatively, the long-range dispersion interaction should be very small.

Dioxinas/toxicidade , Modelos Químicos , Simulação por Computador , Dioxinas/química , Relação Quantitativa Estrutura-Atividade , Análise de Regressão
Chemosphere ; 64(4): 628-33, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16458346


The reductive dechlorination and behavior of p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) was investigated in a paddy soil. Treatment with 5% (w/w) metallic iron (Fe(0)) resulted in sharp decrease of p,p'-DDT, whereas there was no extra effect when 2% (w/w) aluminum sulfate (Al(2)(SO(4))(3)) was added to the Fe(0) treatment. These results suggest that Fe(0) could effectively promote the reductive dechlorination of p,p'-DDT and its metabolites while Al(2)(SO(4))(3) did not show any effect on those processes. Furthermore, p,p'-DDT and its daughter compounds inhibited holistic soil respiration greatly at first but could be metabolized by certain species of indigenous microorganisms after a period of adaptation time in the soil. When treated with Fe(0), the polluted soil produced much less CO(2) while the addition of Al(2)(SO(4))(3) counteracted its negative effect to much extent.

Agricultura , DDT/análise , Microbiologia do Solo , Poluentes do Solo/análise , Solo/normas , Compostos de Alúmen/química , Biodegradação Ambiental , Dióxido de Carbono/química , China , Ferro/química
Acta Virol ; 47(4): 217-21, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-15068376


DNA vaccines have been widely used as effective means of eradicating a variety of viruses, parasites, bacteria as well as means of alleviating allergic and autoimmune diseases and tumors. As interleukin 1 (IL-1) plays an essential role in augmenting both cellular and humoral immune responses to foreign antigens, it may represent a good candidate for an adjuvant to DNA vaccines. Since the inflammatory activity of IL-1 may have a restricted application to DNA vaccines, we explored the possibility of augmenting immune response without unwanted inflammatory effect using IL-1beta 163-171 peptide, which is essential for IL-1 receptor 1 binding. A DNA fragment encoding the human IL-1beta 163-171 peptide of concern was fused to the Hepatitis B virus (HBV) core DNA vaccine, and injected into mice to analyze its immune responses. Compared with the control mice which received hepatitis B virus core antigen (HBcAg) alone, significant increase in not only the HBcAg-specific antibody response but also in T cell proliferation was observed in mice which received IL-1beta 163-171-HBcAg. These results suggest that the DNA fragment encoding the IL-1beta polypeptide of aa 163-171 might represent a good candidate for an adjuvant of DNA vaccines.

Antígenos do Núcleo do Vírus da Hepatite B/genética , Vacinas contra Hepatite B/genética , Vacinas contra Hepatite B/farmacologia , Interleucina-1/genética , Fragmentos de Peptídeos/genética , Vacinas de DNA/genética , Vacinas de DNA/farmacologia , Animais , Sequência de Bases , DNA Recombinante/genética , Escherichia coli/genética , Vacinas contra Hepatite B/imunologia , Humanos , Técnicas In Vitro , Interleucina-1beta , Ativação Linfocitária , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Linfócitos T/imunologia , Vacinas de DNA/imunologia
Appl Opt ; 32(30): 5952-7, 1993 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-20856418


On the basis of oscillation conditions of simultaneous multiple-wavelength lasing that we have established, a larger-energy (1079.5 and 1341.4 nm) dual-wavelength Nd:YAlO(3) pulsed laser has been developed. Output energies of 3.71 and 1.39 J with efficiencies of 1.29% and 0.48% for the 1341.4-and 1079.5-nm wavelengths, respectively, have been achieved. To our knowledge, this is the best result among simultaneous dual-wavelength solid-state lasers to date. The temporal and spatial distributions of these beams obtained from a free-running dual-wavelength Nd:YAlO3 pulsed laser have also been measured. Experimental results show that the temporal and spatial overlap of the two beams is quite good for this type of laser.