Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 104
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Dent Res ; 99(3): 249-256, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31977286

RESUMO

Lateral cephalometry has been widely used for skeletal classification in orthodontic diagnosis and treatment planning. However, this conventional system, requiring manual tracing of individual landmarks, contains possible errors of inter- and intravariability and is highly time-consuming. This study aims to provide an accurate and robust skeletal diagnostic system by incorporating a convolutional neural network (CNN) into a 1-step, end-to-end diagnostic system with lateral cephalograms. A multimodal CNN model was constructed on the basis of 5,890 lateral cephalograms and demographic data as an input. The model was optimized with transfer learning and data augmentation techniques. Diagnostic performance was evaluated with statistical analysis. The proposed system exhibited >90% sensitivity, specificity, and accuracy for vertical and sagittal skeletal diagnosis. Clinical performance of the vertical classification showed the highest accuracy at 96.40 (95% CI, 93.06 to 98.39; model III). The receiver operating characteristic curve and the area under the curve both demonstrated the excellent performance of the system, with a mean area under the curve >95%. The heat maps of cephalograms were also provided for deeper understanding of the quality of the learned model by visually representing the region of the cephalogram that is most informative in distinguishing skeletal classes. In addition, we present broad applicability of this system through subtasks. The proposed CNN-incorporated system showed potential for skeletal orthodontic diagnosis without the need for intermediary steps requiring complicated diagnostic procedures.

2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 53(10): 1000-1006, 2019 Oct 06.
Artigo em Chinês | MEDLINE | ID: mdl-31607045

RESUMO

Objective: To evaluate the cost-effectiveness of potential government fully-funded influenza vaccination for diabetics in our country. Methods: From the societal perspective, a decision tree model was developed to compare outcomes (including impact on the influenza-related outpatient consultation, hospitalization and excess mortality, and quality-adjusted life years (QALY), as well as incremental cost-effectiveness ratio (ICER)) of a national fully-funded vaccination programme in the population with diabetes and status quo (i.e., vaccinated with out-of-pocket payment, with a uptake rate of zero), using the published data with regarding to influenza related ILI (influenza-like illness) consultation rate, hospitalization rate and excess mortality rate, health-related quality of life and economic burden, diabetes prevalence, population size, health seeking behaviour, vaccine uptake rate, vaccine efficacy/effectiveness, etc. A time horizon of 1 year was used in the present analysis, and all costs were expressed in CNY in 2016 using the consumer price index. All results are presented in M (P(25), P(75)). Results: In the scenario of 40% vaccination coverage in the population with diabetes, government fully-funded vaccination programme was estimated to cost 1.71 (1.67, 1.75) billions CNY, and expected to prevent 110 000 (81 000, 143 000) influenza-related ILI consultations, 36 000 (28 000, 44 000) influenza-related SARI hospitalizations and 12 000 (9 000, 16 000) influenza-related deaths due to respiratory and cardiovascular diseases. A total of 108 000 (82 000, 142 000) QALY were estimated to be gained. The ICER was 10 088 (7 365, 14 046) CNY per QALY gained. The probability of cost-effectiveness of the fully-funded vaccination programme was 99.1% at a threshold of 53 680 CNY per QALY gained (GDP per capita in 2016). Conclusion: Government fully-funded influenza vaccination in population with diabetes is cost-effective, and thus is recommended as the key strategy of diabetes prevention and control.


Assuntos
Diabetes Mellitus , Vacinas contra Influenza/economia , Influenza Humana , Vacinação/economia , China , Análise Custo-Benefício , Governo , Humanos , Qualidade de Vida , Anos de Vida Ajustados por Qualidade de Vida
3.
Zhonghua Er Ke Za Zhi ; 57(6): 445-451, 2019 Jun 02.
Artigo em Chinês | MEDLINE | ID: mdl-31216802

RESUMO

Objective: To study the clinical characteristics of outpatients with hand, foot and mouth disease (HFMD) caused by different serotypes of enteroviruses. Methods: This was a prospective study. From February 2017 to March 2018, 563 outpatients with HFMD were enrolled by systematic sampling in the Department of Infectious Diseases, Henan Children's Hospital. Throat swabs were collected to determine the serotypes via PCR. Demographic, clinical, and laboratory data were collected by standard questionnaire. All cases were followed up twice at 2 and 9 weeks after the initial outpatient visit through telephone interview. A total of 563 cases were enrolled and 555 (98.6%) cases were positive for human enteroviruses, including 338 (60.9%) males. Analyses were stratified by enterovirus serotypes, Chi square test or Fisher's exact test, Rank sum test was used for comparison among different groups. Results: The age of 555 cases was 24.2 (16.4, 41.3) months. Among them 44.0% (224 cases) were identified as coxsackievirus (CV)-A6, while 189 cases, 35 cases, 14 cases and 73 cases were identified as CV-A16, enterovirus (EV)-A71, CV-A10 and other serotypes, respectively. Fever (≥37.5 ℃) was present in 51.4% (285/555) of laboratory confirmed cases. The proportions of fever in cases of CV-A6 (68.9%(168/244)) and CV-A10 (12/14) were significantly higher than those in cases of CV-A16 (31.7%(60/189),χ(2)=57.344,14.313,both P=0.000), other serotypes (43.8%(32/73),χ(2)=15.101 and 8.242, P=0.000 and 0.004) and EV-A71 (37.1%(13/35), χ(2)=13.506 and 9.441, P=0.000 and 0.002) respectively. There was no significant difference between CV-A6 and CV-A10 in presentation of fever (χ(2)=1.785, P=0.182). There were 359 cases (64.7%) with eruptions in mouth, hands, feet and buttocks. Cases infected with EV-A71 had the highest proportions (74.3%(26/35)) of rash emerging simultaneously in mouth, hands, feet, and buttocks. The proportion in cases of CV-A16, CV-A6, CVA10 and other serotype were 73.5% (139/189), 61.9% (151/244), 7/14 and 49.3% (36/73), respectively. The proportion of rash on other parts of body, such as face, limbs or torso in cases infected with CV-A6 (16.8% (41/244)) was the higherest and the proportion in cases of CV-A16, EV-A71, CV-A10 or other serotypes were 8.5% (16/189) , 5.7% (2/35) , 1/14, 6.8% (5/73) , respectively. None of these cases developed serious complications. Desquamation occurred in 45.5% (179/393) cases 7.5 (5.0, 9.0) days after disease onset and 13.5% (53/393) cases showed onychomadesis 31.0 (18.0, 33.5) days after disease onset. The proportion of desquamation and onychomadesis associated with CV-A6 (64.2% (95/148) and 31.8% (47/148)) was significantly higher than CV-A16 (31.8% (49/154) and 1.3% (2/154), χ(2)=33.601 and 52.482, both P=0.000) and other serotypes (38.0%(19/50) and 6.0%(3/50),χ(2)=10.236 and 12.988, P=0.001 and 0.000). Desquamation appeared more in cases of CV-A6 than in cases of CV-A10 (2/11,χ(2)=9.386, P=0.002), with the proportion of onychomadesis higher in CV-A6 than in EV-A71 (3.3% (1/30),χ(2)=11.088, P=0.001). Conclusion: Clinical manifestation such as fever, rash emerging parts, desquamation and onychomadesis are different among outpatient HFMD cases infected with CV-A16, CV-A6, EV-A71, CV-A10 and other enteroviruses.


Assuntos
Infecções por Enterovirus/diagnóstico , Enterovirus/isolamento & purificação , Doença de Mão, Pé e Boca/epidemiologia , Pré-Escolar , China/epidemiologia , Infecções por Enterovirus/epidemiologia , Doença de Mão, Pé e Boca/virologia , Hospitalização , Humanos , Pacientes Internados , Masculino , Pacientes Ambulatoriais , Estudos Prospectivos
4.
Eur Rev Med Pharmacol Sci ; 23(9): 3561-3568, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31114979

RESUMO

OBJECTIVE: The aim of this paper is to investigate the effect of BDNF-TrKB pathway on AOH by accessing its regulatory role in retinal ganglion cell apoptosis. MATERIALS AND METHODS: Acute ocular hypertension (AOH) model in rats was established by anterior chamber perfusion to increase intraocular tension. Rats were randomly divided into AOH group, control group and k252a group, with ten rats in each group. Rats were sacrificed 72 h after animal procedures and eyeballs were harvested. HE staining was used to observe retinal structural changes at different time points. Immunohistochemical staining was used to observe the BDNF-positive cells in retinal tissues. TUNEL staining was conducted to measure apoptosis of retinal ganglion cells. Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) and Western blot were performed to detect mRNA and protein levels of BDNF, TrKB, PI3K and ERK1 in retinal tissues, respectively. RESULTS: HE and TUNEL staining showed significant pathological changes and abundant apoptotic cells in rat retina of AOH group and k252a group compared with those of the control group (p<0.05). The number of survived retinal ganglion cells in the AOH group was lower than that of the control group (p<0.05). K252a group had the lowest number of survived retinal ganglion cells. Immunohistochemical results showed that BDNF was rarely expressed in rat retinal tissues of the control group, which was remarkably pronounced in the AOH group and k252a group. The number of BDNF-positive cells in the k252a group was higher than that in the AOH group (p<0.05). RT-PCR and Western blot indicated that mRNA and protein levels of relative genes in BDNF-TrKB and PI3K/ERK1 pathways were upregulated in AOH group (p<0.05), but were significantly downregulated in k252a group (p<0.05). CONCLUSIONS: BNDF-TrKB pathway exerts a protective effect on retina against acute ocular hypertension by reducing retinal cell apoptosis.

5.
Zhonghua Liu Xing Bing Xue Za Zhi ; 40(1): 79-83, 2019 Jan 10.
Artigo em Chinês | MEDLINE | ID: mdl-30669736

RESUMO

Objective: To estimate the serotype and age-specific hospitalization burden associated with hand, foot and mouth disease (HFMD) in Anhua county of Hunan province, between October 2013 and September 2016. Methods: We collected hospitalization records of HFMD patients from 6 virological surveillance hospitals, and reimbursement records through new rural cooperative medical system from 23 township health centers to estimate the age-specific hospitalization burden of HFMD in Anhua. Combined with the results of virological surveillance, the serotype-specific hospitalization burden of HFMD in Anhua, was estimated. Results: During the three years, it was estimated that 3 541 clinical diagnosed HFMD cases, including 3 146 laboratory-confirmed HFMD cases, were hospitalized in Anhua, but only one was diaguosed as being severe. The estimated average hospitalization rate was 723/100 000(95%CI: 699/100 000-747/100 000) for clinical diagnosed HFMD and 642/100 000 (95%CI: 620/100 000-665/100 000) for laboratory-confirmed HFMD between October 2013 and September 2016. The cases caused by Cox A16 (208/100 000) and Cox A6 (202/100 000) had higher hospitalization rates compared with the cases caused by EV71 (130/100 000), Cox A10 (38/100 000) and other enterovirus (64/100 000), and the difference was statistically significant (P<0.001). HFMD-associated hospitalization rates peaked in children aged 1 year (3 845/100 000), and then decreased with age. Compared with the hospitalized HFMD caused by EV71 and Cox A16, Cox A6-associated hospitalizations mainly occurred in younger age groups (P<0.001). Conclusion: Our study revealed a substantial hospitalization burden associated with mild HFMD caused by EV71, Cox A16, Cox A6 and Cox A10, especially in young children, in Anhua.


Assuntos
Enterovirus Humano A/isolamento & purificação , Infecções por Enterovirus/epidemiologia , Doença de Mão, Pé e Boca/epidemiologia , Doença de Mão, Pé e Boca/virologia , Hospitalização/estatística & dados numéricos , Criança , China/epidemiologia , Enterovirus , Enterovirus Humano A/genética , Infecções por Enterovirus/virologia , Doença de Mão, Pé e Boca/etnologia , Hospitais/estatística & dados numéricos , Humanos , Lactente , Sorogrupo
6.
Ann Hematol ; 98(2): 473-479, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30341538

RESUMO

Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Recent studies have shown that mesenchymal stromal cells (MSCs) display potent immunosuppressive effects and can support normal hematopoiesis. In a multi-center trial, we co-transplanted culture-expanded donor-derived bone marrow MSCs (BM-MSCs) into 35 children with severe aplastic anemia (SAA) undergoing haplo-HSCT. All 35 patients (100%) achieved hematopoietic reconstitution and showed sustained full donor chimerism. The median time for myeloid engraftment was 14 days (range 10-22 days), while that for platelet engraftment was 18 days (range 9-36 days). The incidence of grade II-IV acute GVHD and chronic GVHD was 25.71 and 22.86%, respectively. The overall survival rate was 85.71% with a median of 22 months (range 3.5-37 months). The combined transplantation of haploidentical HSCs and BM-MSCs into children with SAA without an HLA-identical sibling donor is relatively safe and may represent an effective new therapy to improve survival rates and reduce the risk of graft failure.


Assuntos
Anemia Aplástica/mortalidade , Anemia Aplástica/terapia , Transplante de Células-Tronco Hematopoéticas , Transplante de Células-Tronco Mesenquimais , Doadores de Tecidos , Doença Aguda , Adolescente , Aloenxertos , Anemia Aplástica/sangue , Criança , Pré-Escolar , Intervalo Livre de Doença , Feminino , Doença Enxerto-Hospedeiro/sangue , Doença Enxerto-Hospedeiro/mortalidade , Humanos , Incidência , Masculino , Índice de Gravidade de Doença , Taxa de Sobrevida , Quimeras de Transplante/sangue
7.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 53(12): 815-820, 2018 Dec 09.
Artigo em Chinês | MEDLINE | ID: mdl-30522204

RESUMO

Objective: To analyze the incidence and possible risk factors of 19 fractured implants out of 8 468 implants in 3 184 cases. Methods: During the 22-year clinical practice, clinical records of 18 patients with 19 fractured implants in 3 184 cases with 8 468 implants were analyzed to determine the following factors: location of the fractured implants, prosthodontics option, date of implant fracture, dimensions of fractured implants, complications prior to implant fracture and parafunctional habit. An evaluation of fractured implants was performed to identify possible factors that may predispose an implant to a higher risk of fracture. Results: Overall, the average duration of service of the implants was (7.0±4.5) years. Implant fracture occurred in 7 Camlog implants, 7 Nobel replace implants, 3 Ankylos implants and 2 Brånemark implants. No Thommen implant fractures were recorded. Amongst the 19 fractured implants, 8 occurred at the thinnest wall portion of the implant neck, 8 at the end of screw and 3 at the self-tapping thread region. All fractures were observed after functional loading. Furthermore, 9/19 (47.4%) of fractures occurred in the maxilla, indicating similar incidence rates in both arches (P=0.065). Most of fractures (16/19) occurred in the molar region and 18/19 in single implant-supported restorations. Totally 17 cases had received metal occlusal restorations. In 6 cases (35.5%), previous bone destruction apically extending to the level of implant fracture was documented before any clinical signs of fracture. Three fractured implants were removed and simultaneously re-implanted with larger-diameter implants, while the rest of the cases were left to heal, followed by a second-stage surgery. Conclusions: Within the limitation of this analysis, the study demonstrated that appropriate implant-abutment connection design, implant diameter, prosthetic strategy and bone resorption are crucial to the long-term performance of implants. There is no significant difference of fractures rates in both archs.


Assuntos
Planejamento de Prótese Dentária , Falha de Restauração Dentária , Maxila , Implantação Dentária Endo-Óssea , Implantes Dentários , Prótese Dentária Fixada por Implante , Humanos , Fatores de Risco
8.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi ; 36(10): 761-764, 2018 Oct 20.
Artigo em Chinês | MEDLINE | ID: mdl-30541199

RESUMO

Objective: To investigate the health status of radiation workers in a city and provide evidence for the health management of radiation workers. Methods: To investigate the health status of radiation workers in a city and provide evidence for the health management of radiation workers. Results: The majority of radiation workers are engaged in diagnostic radiology, male is more than female. The abnormal rate of micronuclear (0.59‰) and chromosome aberration (0.47%) was highest in nuclear medicine workers. The abnormal rate of micronuclear and chromosome aberration was similar with interventional and diagnostic radiology. Expect for micronuclear (χ(2)=32.945, P<0.01) and chromosome aberration (χ(2)=75149.737, P<0.01) , other radiation sensitive indicators have no difference. The abnormal rate of thyroid function (18.8%) (χ(2)=12.084, P<0.01) , micronuclear (0.25‰) (χ(2)=57.359, P<0.01) , chromosome aberration (0.08%) (χ(2)=17.209, P<0.01) in group whose service length exceeding 20 years was higher than other service length groups. There is no statistical difference in other radiation sensitive indicators among different service length group. Conclusion: Long-term low doses of ionizing radiation could affect radiation worker's health, expecially radiation workers engaged in nuclear medicine and radiotherapy. We must pay attention to occupaitonal health care and management to ensure radiation worker's health.


Assuntos
Saúde do Trabalhador , Radiologia , Aberrações Cromossômicas , Cidades , Feminino , Humanos , Masculino , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/estatística & dados numéricos , Radiação Ionizante
9.
Zhonghua Liu Xing Bing Xue Za Zhi ; 39(10): 1291-1297, 2018 Oct 10.
Artigo em Chinês | MEDLINE | ID: mdl-30453425

RESUMO

The process of globalization increases the risk of global transmission of infectious diseases, resulting in pressure for country's prevention and control of imported infectious disease. Based on the risk assessment of disease importation and local transmission, a strategy that conducting importation prevention and routine prevention and control before the importation of disease and taking emergency control measures after the importation of disease was developed. In addition, it is important to take part in global infectious disease response action, aid the countries with outbreak or epidemic to actively decrease the risk of disease importation.


Assuntos
Doenças Transmissíveis Importadas/prevenção & controle , Doenças Transmissíveis Importadas/transmissão , Surtos de Doenças/prevenção & controle , Viagem , Doenças Transmissíveis , Doenças Transmissíveis Importadas/epidemiologia , Epidemias , Saúde Global , Humanos , Medição de Risco
10.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 53(10): 665-668, 2018 Oct 09.
Artigo em Chinês | MEDLINE | ID: mdl-30392222

RESUMO

Objective: To evaluate the preliminary clinical outcome of socket shield technique in maxillary anterior region. Methods: Nine patients were treated with socket shield technique in Peking University School and Hospital of Stomatology from February 2012 to December 2015 were enrolled in this study. Ten implants were placed and restored immediately. After 12-48 months' follow-up (averaged 32 months), the peri-implant hard and soft tissue were clinically evaluated. Results: No implants were lost during the observation period, resulting a cumulate 32-month survival. The pink esthetic score (PES) was 13.5. Mesial and distal bone loss were 0.17 mm and 0.22 mm respectively. Conclusions: To achieve good esthetic results, socket shield technique may be an option for maxillary anterior region immediate implant placement.


Assuntos
Implantes Dentários para Um Único Dente , Carga Imediata em Implante Dentário , Alvéolo Dental , Estética Dentária , Seguimentos , Humanos , Maxila , Resultado do Tratamento
11.
J Laryngol Otol ; 132(8): 748-752, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29996959

RESUMO

OBJECTIVE: Various surgical approaches have been described to remove tumours in the parapharyngeal space. This study investigated the feasibility of a transoral approach in the surgical management of parapharyngeal space benign tumours located in the medial portion of the carotid sheaths and extending toward the skull base. METHODS: Thirty-two patients were selected and underwent a transoral or an endoscope-assisted transoral approach in the surgical management of parapharyngeal space benign tumours located in the medial portion of the carotid sheaths. Medical photographs were used. RESULTS: All patients underwent complete resection of their lesions via a transoral or endoscope-assisted transoral approach. None of the patients demonstrated residual or recurrent neoplasms, either clinically or radiographically, during their follow up. CONCLUSION: Based on our studies, we assert that transoral and endoscope-assisted transoral approaches are suitable in managing parapharyngeal space benign tumours located in the medial portion of the carotid sheaths and extending toward the skull base.


Assuntos
Adenoma Pleomorfo/cirurgia , Fibromatose Agressiva/cirurgia , Cirurgia Endoscópica por Orifício Natural , Neurilemoma/cirurgia , Neurofibroma/cirurgia , Neoplasias Faríngeas/cirurgia , Adenoma Pleomorfo/patologia , Adolescente , Adulto , Artérias Carótidas , Criança , Feminino , Fibromatose Agressiva/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Neurilemoma/patologia , Neurofibroma/patologia , Neoplasias Faríngeas/patologia , Estudos Retrospectivos , Base do Crânio , Adulto Jovem
12.
Zhonghua Yu Fang Yi Xue Za Zhi ; 52(6): 661-667, 2018 Jun 06.
Artigo em Chinês | MEDLINE | ID: mdl-29886690

RESUMO

Objective: To understand characteristics of demographic, seasonal and spatial distribution of H5N1 cases in major countries of Asia (Indonesia, Cambodia, Vietnam, China) and Africa (Egypt). Methods: Through searching public data resource and published papers, we collected cases information in five countries from May 1st, 1997 to November 6th, 2017, including general characteristics, diagnosis, onset and exposure history, etc. Different characteristics of survived and death cases in different countries were described and χ(2) test was used to compare the differences among death cases and odds ratio (OR) and 95%CI value was used to compare death risk in different countries. Results: A total of 856 cases were reported in five countries with Egypt had the most cases (44.3%). The highest number of cases were reported in 2015 (18.3%). 53% cases were reported from January to March, and 96.1% of cases had the history of poultry exposure. 64.2% (43 cases) cases in China had live poultry market exposure, but the sick/dead poultry exposure was the major exposure for cases in other four countries. 452 death cases were reported in five countries, and the fatality rate was 52.8%. With Egypt as the reference group, the highest death risk was seen in Indonesia (OR (95%CI): 11.52 (7.46-17.77)), followed by Cambodia (OR (95%CI): 4.27(2.37-7.69)) and China (OR (95%CI): 2.87 (1.73-4.74)). The age distribution of death cases among 5 countries was statistically significant, and the highest fatality rate was in 15-54 years group in Egypt (83.6%, 102 cases), while in Cambodia the highest fatality rate was in 0-14 years group (76.9%, 30 cases). The highest number of deaths were reported in 2006, and 48.3% were reported from January to March. There was difference in exposure routes among 5 countries (χ(2)=43.85, P=0.001), 63.2% (24 cases) of the death cases in China had live poultry market exposure. 92.9% (79 cases), 83.3% (40 cases) and 100.0% (38 cases) death cases in Indonesia, Vietnam and Camodia had sick/dead poultry exposure, respectively;and 81.6% (31 cases) of the death cases in Egypt had backyard poultry exposure. Conclusion: The geographical distribution, seasonal age, gender, exposure matter and outcome of H5N1 cases in five countries were different.


Assuntos
Virus da Influenza A Subtipo H5N1 , Influenza Humana/epidemiologia , Adolescente , Adulto , África/epidemiologia , Animais , Ásia/epidemiologia , Criança , Pré-Escolar , Exposição Ambiental/estatística & dados numéricos , Humanos , Lactente , Recém-Nascido , Influenza Aviária/epidemiologia , Influenza Aviária/transmissão , Influenza Humana/mortalidade , Pessoa de Meia-Idade , Aves Domésticas , Adulto Jovem
13.
Public Health ; 157: 121-126, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29524810

RESUMO

OBJECTIVES: Findings regarding the benefits of fruit and vegetables (FV) on weight control are inconsistent and little is known among Chinese populations. Therefore, we examined the relationship between change in FV consumption, weight, and change in body mass index (BMI) among Chinese adults, participants of the China Health and Nutrition Survey (CHNS). STUDY DESIGN: A prospective cohort study. METHODS: Two waves of CHNS conducted in 2006 and 2011 were used. Continuous FV consumption increase was considered as the exposure and changes in weight and BMI as outcomes. Change in FV consumption was categorized into quintiles. Analysis of covariance and multiple linear regression models, after controlling for potential confounders such as energy intake, physical activity, and smoking, were used to describe the relationship between change in FV consumption and change in weight and BMI. RESULTS: A total of 4357 participants aged 18-65 years were included in this study. The respective weight and BMI gains in male individuals were 1.81 kg and 0.73 kg/m2 in the fifth quintile of FV change relative to individuals in the first quintile (3.67 kg for weight gain and 1.48 kg/m2 for BMI gain). An increase in FV consumption by 100 g was associated with a 211 g weight loss (B = -2.11; 95% confidence interval [CI], -3.34, -0.89, P < 0.001) and a decrease in BMI by 0.94 kg/m2 (B = -0.94; 95% CI, -1.36, -0.46, P < 0.001) in men; and a 140 g weight loss (B = -0.14; 95% CI, -0.97, 0.69, P = 0.74) and a decrease in BMI by 0.29 kg/m2 BMI (B = -0.29; 95% CI, -0.63, 0.06, P = 0.11) in women. CONCLUSIONS: Increase in FV consumption was associated with statistically significant weight loss and decrease in BMI among Chinese men, and, although suggested, weight loss among women was not significant. Considering the protective effect of FV on human health, increasing FV consumption in the Chinese population is recommended.


Assuntos
Índice de Massa Corporal , Peso Corporal , Dieta/estatística & dados numéricos , Frutas , Verduras , Adolescente , Adulto , Idoso , China/epidemiologia , Dieta/efeitos adversos , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos Nutricionais , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Estudos Prospectivos , Adulto Jovem
14.
Eur Rev Med Pharmacol Sci ; 21(21): 4946-4951, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29164563

RESUMO

OBJECTIVE: Traumatic optic neuropathy (TON) usually refers to the indirect damage to the optical nerve, which can cause partial or complete blindness. Melatonin (MT) is a kind of indole hormone, and the retina is one of its natural sites of secretion in the human body. This study aims to explore MT in the retina and optic nerve injuries due to TON. MATERIALS AND METHODS: Sprague-Dawley (SD) rats were used for TON model in the study. After operation, rats were treated with MT or phosphate buffered saline (PBS) for 4, 7, 14, 21, and 28 days before sacrifice. The changes in retinal ganglion cells (RGCs) were observed via hematoxylin-eosin (HE) staining. Terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) staining was applied to observe apoptosis. Immunofluorescence staining was applied to detect caspase-3 and Western blot was used to detect LC3, cleaved caspase-3 and glyceraldehyde phosphate dehydrogenase (GAPDH). RESULTS: The number of RGCs in MT group increased compared to the model group. After MT treatment, the increased number of TUNEL positive cells and the increased number of caspase-3 positive cells in the retina of MT group was alleviated. Moreover, Western blot analysis revealed that the LC3-II/LC3-I ratio in the retinal tissue of MT group was further increased, while the increased cleaved caspase-3 protein level in the retina of MT group was alleviated compared to the model group. CONCLUSIONS: The results of this study revealed that MT therapy affects the apoptosis level of RGCs after TON through alleviating the increased caspase-3 protein level. Its mechanism may be that it further up-regulates the autophagy level of RGCs after TON, ultimately inhibiting the apoptosis of RGCs after TON and playing a neuroprotective role.


Assuntos
Melatonina/uso terapêutico , Traumatismos do Nervo Óptico/tratamento farmacológico , Animais , Autofagia/efeitos dos fármacos , Caspase 3/metabolismo , Feminino , Gliceraldeído-3-Fosfato Desidrogenases/metabolismo , Masculino , Melatonina/farmacologia , Proteínas Associadas aos Microtúbulos/metabolismo , Traumatismos do Nervo Óptico/patologia , Ratos , Ratos Sprague-Dawley , Células Ganglionares da Retina/metabolismo , Células Ganglionares da Retina/patologia
15.
Public Health ; 149: 65-70, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28554164

RESUMO

OBJECTIVES: To explore the association between obesity phenotype and the risk of hypertension among Chinese adults. STUDY DESIGN: A prospective cohort study. METHODS: Two waves of data were collected in 2009 and 2011 by the China Health Nutrition Survey. According to International Diabetes Federation and Chinese obesity criteria, participants were divided into four groups: metabolically healthy non-overweight/obesity (MHNO), metabolically healthy overweight/obesity (MHO), metabolically abnormal non-overweight/obesity (MANO), and metabolically abnormal overweight/obesity (MAO). Logistic regression model was performed to estimate the risk of hypertension with obesity phenotype. RESULTS: Among a total of 4604 adults aged 18-65 years at baseline, 467 developed hypertension during the 2-year follow-up period. After adjusting for several potential confounders, significantly increased risks for hypertension were found for participants in MHO (odd ratio [OR]: 1.78, 95% confidence interval [CI]: 1.39-2.27), MANO (OR: 1.71, 95% CI: 1.02-2.86), and MAO (OR: 3.35, 95% CI: 2.54-4.42) group compared with the MHNO group. CONCLUSION: Metabolically abnormal individuals, regardless of their body weight status, showed significantly higher risks for hypertension compared with healthy non-overweight/obese group. Furthermore, MHO individuals had significantly increased risk of incident hypertension.


Assuntos
Hipertensão/epidemiologia , Obesidade , Fenótipo , Adolescente , Adulto , Idoso , China/epidemiologia , Feminino , Inquéritos Epidemiológicos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Medição de Risco , Adulto Jovem
16.
Zhonghua Liu Xing Bing Xue Za Zhi ; 38(4): 435-440, 2017 Apr 10.
Artigo em Chinês | MEDLINE | ID: mdl-28468058

RESUMO

Objective: To analyze the epidemiological characteristics of human brucellosis in northern and southern areas of China, and to develop national strategies for brucellosis prevention and control. Methods: Individual data on human brucellosis was collected from the National Notifiable Infectious Disease Reporting Information System to describe the situation of brucellosis in China during 2015-2016. Epidemiological features of the disease in northern and southern areas of China were analyzed. Results: A total of 104 125 cases were reported in mainland China during 2015-2016, with an average incidence rate as 3.81/100 000. The overall incidence rate from the northern provinces was 7.77/100 000 in 2016, a 18.6% decrease from 2015 (9.55/100 000), whereas the incidence rate in the southern provinces was 0.27/100 000 in 2016, with an increase of 28.6% than 0.21/100 000 in 2015. 90.0% of the newly infected counties mainly distributed in southern China. As for the locations of reporting cases, most of them were in the same counties in the northern areas (52.3%) while most cases in the southern areas (59.6%) were imported from other counties. The median age of the cases was 48 (IQR: 38-58) years, with male-to-female ratios as 2.7∶1 in the north and 2.2∶1 in the south. Majority of the cases were occupation-related, from both the northern (86.8%) and southern (62.7%) areas. Human brucellosis occurred every month throughout the year but with an obvious seasonal increase between March and July. Conclusions: Different epidemiological features of human brucellosis appeared in both northern and southern areas of China. The disease was seen endemic in the northern and dispersal in the southern provinces. Appropriate strategies for brucellosis prevention and control should be developed, according to the different epidemiological characteristics in the northern or southern areas.


Assuntos
Brucelose/epidemiologia , Notificação de Doenças , Adulto , Distribuição por Idade , Animais , Brucella , Brucelose/diagnóstico , China/epidemiologia , Notificação de Doenças/estatística & dados numéricos , Epidemias , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade
17.
Int J Oral Maxillofac Surg ; 46(4): 531-538, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28062250

RESUMO

The aim of this study was to analyze and compare the long-term clinical outcomes of mature third molar autotransplantation in surgically created sockets and fresh extraction sockets with regard to survival and functional success rates. A total of 65 third molars with completely formed roots were autotransplanted in 60 patients (average age 33.1 years). Thirty-six of the teeth were autotransplanted into surgically created sockets with or without guided bone regeneration (GBR; delayed autotransplantation), while 29 were autotransplanted into fresh extraction sockets (immediate autotransplantation; control group). All patients underwent annual clinical and radiographic examinations (average follow-up 9.9 years, range 7-13 years). The survival rates for the control, GBR, and no GBR groups were 93.1%, 95.2%, and 80.0%, respectively, with no significant differences among the groups. There were no statistically significant differences among the groups with regard to the frequency of inflammatory root resorption or root ankylosis. Age did not influence the clinical outcomes. These results suggest that the autotransplantation of third molars with completely formed roots is effective in both surgically created and fresh extraction sockets and provides a high long-term success rate if cases are selected and treated appropriately.


Assuntos
Dente Serotino/transplante , Extração Dentária/métodos , Alvéolo Dental/cirurgia , Transplante Autólogo , Adulto , Feminino , Regeneração Tecidual Guiada Periodontal , Humanos , Masculino , Estudos Prospectivos , Taxa de Sobrevida , Resultado do Tratamento
18.
J Fish Biol ; 89(6): 2607-2624, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27687511

RESUMO

This paper presents preliminary data on the genetic diversity and population structure of Hyporhamphus sajori by analysing a 510 bp sequence in the mitochondrial DNA (mtDNA) control region and eight polymorphic microsatellite DNA loci. The H. sajori individuals from different locations were indistinguishable from one another based on mtDNA variation, as demonstrated with a neighbour-joining tree and minimum spanning network analysis. Low level of genetic diversity and the absence of population structure in H. sajori from the north-west Pacific Ocean, combined with negative indices for neutral evolution in these populations, suggest that H. sajori underwent a population expansion after a recent bottleneck. The Structure analysis, discriminant analysis of principal components (DAPC) and the pair-wise ΦST values after Bonferroni correction using eight microsatellite loci provided no clear inference on the genetic differentiation and thus no evidence of population structure of H. sajori. The genetic connectivity among locations might be due to fairly high gene flow via transport of eggs and larvae by the Kuroshio and Tsushima warm current. This study revealed low levels of genetic diversity and suggested high level of contemporary gene flow among populations of H. sajori in the East (Japan) Sea and the Pacific Ocean.


Assuntos
Beloniformes/genética , Polimorfismo Genético , Animais , Beloniformes/fisiologia , DNA Mitocondrial/química , DNA de Cadeia Simples/química , Fluxo Gênico , Marcadores Genéticos , Japão , Repetições de Microssatélites , Oceano Pacífico , Filogenia , Dinâmica Populacional , Análise de Componente Principal , RNA Bacteriano/química , Análise de Sequência de DNA , Movimentos da Água
19.
Artigo em Chinês | MEDLINE | ID: mdl-27514261

RESUMO

OBJECTIVE: To investigate chromosome aberration and micronucleus frequency in peripheral blood lymphocytes in workers engaged in radiation for a long time, to reduce occupational hazard caused by ionizing radiation, and to further strengthen health surveillance. METHODS: A total of 366 members of medical staff engaged in radiation work who underwent physical examinations in Hangzhou Hospital of Prevention and Treatment of Occupation Diseases from 2014 to 2015 were enrolled as radiation group, consisting of staff engaged in X-ray diagnosis, diagnostic radiology, radiotherapy, and interventional radiology. Another 100 members of medical staff without exposure to radiation were enrolled as control group. Whole blood culture was used to measure chromosome aberration and micronucleus frequency in peripheral blood lymphocytes. RESULTS: The radiation group had a significantly higher rate of chromosome aberration than the control group (0.30% vs 0.09% , χ(2)= 13.43, P<0.01), as well as a significantly higher micronucleus frequency than the control group (2.09‰ vs 0.08‰, χ(2)=74.4, P<0.01). The abnormal rates of chromosome aberration and micronucleus showed no significant differences across radiation workers with different working years (P>0.05). The staff engaged in X-ray diagnosis, diagnostic radiology, radiotherapy, and interventional radiology had rates of chromosome aberration of 0.25%, 0.25%, 0.23%, and 0.41%, respectively, which showed a significant difference between the staff at these four posts (χ(2)=8.22, P<0.05); the micronucleus frequencies in the staff at these four posts were 1.36‰, 1.28‰, 1.14‰, and 3.79‰, respectively, and showed a significant difference between the staff at these four posts (χ(2)=251.09, P<0.01). CONCLUSION: Radiation workers are exposed to lowdose ionizing radiation for a long time, which may cause significant increases in the rate of chromosome aberration and micronucleus frequency in peripheral blood lymphocytes.


Assuntos
Aberrações Cromossômicas , Doenças Profissionais , Exposição Ocupacional , Humanos , Linfócitos , Testes para Micronúcleos , Radiação Ionizante , Radiologia , Raios X
20.
Zhonghua Liu Xing Bing Xue Za Zhi ; 37(2): 139-63, 2016 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-26917506

RESUMO

In order to promote the prevention and control programs on rabies in our country, to regulate the prevention and disposition of rabies and to reduce the deaths caused by rabies, the Chinese Center for Disease Control and Prevention has organized a panel of experts, in the reference with Guidelines issued by WHO, American Advisory Committee on Immunization Practices, and the latest research progress from home and abroad, and compiled this document-"Technical Guidelines for Human Rabies Prevention and Control (2016)". The Guidelines conducted a systematic review on the etiology, clinical characteristics, laboratory diagnosis, epidemiology of rabies and provided evidence on varieties, mechanisms, effects, side-effects and security of rabies vaccine, as well as on other preparations on passive immunity of its kind, on methods related to prevention and disposition of exposure etc, finally to have come up with the recommendation on the above mentioned various techniques. The guidelines will be used by staff working on prevention and control of rabies from the Center for Disease Control and Prevention at all levels, from the departments of outpatient and divisions of infection and emergency control in all the medical institutions. The guideline will be updated and revised, following the research progress from home and abroad.


Assuntos
Guias de Prática Clínica como Assunto , Raiva/prevenção & controle , China , Humanos , Vacinas Antirrábicas , Vacinação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA